CN105521226A - Traditional Chinese medicinal composition for treating iron-deficiency anemia and preparation method of traditional Chinese medicinal composition - Google Patents

Traditional Chinese medicinal composition for treating iron-deficiency anemia and preparation method of traditional Chinese medicinal composition Download PDF

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CN105521226A
CN105521226A CN201610096293.7A CN201610096293A CN105521226A CN 105521226 A CN105521226 A CN 105521226A CN 201610096293 A CN201610096293 A CN 201610096293A CN 105521226 A CN105521226 A CN 105521226A
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radix
parts
caulis
herba
deficiency anemia
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梁云飞
林双
严灿梅
黄源春
李柏霖
杨北妮
林艳英
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Guangxi Wuzhou Pharmaceutical Group Co Ltd
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Guangxi Wuzhou Pharmaceutical Group Co Ltd
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Abstract

The invention discloses a traditional Chinese medicinal composition for treating iron-deficiency anemia and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition is prepared from the following raw materials: herba hedyotideae, sarmentose pepper herb, the root and rhizome of ripqrian greenbrier, radix achyranthis bidentatae, the root or stem of smallflower parabarium, fruticose breyniae leaf and twig, the leaf of Hongkong kumquat, sheepear inula herb, diverse wormwood herb, vines and kernels of Entada phaseoloides (L.) Merr., hyptis suaveolens, Cudrania cochinchinensis Kudo et Masam, Zanthoxylum nitidum var.fastuosum, suberect spatholobus stem, the twig and leaf of common claoxylon, the root of Solanum surattense Burm. f., radix angelicae pubescentis, the seeds of garden balsam, the fruits of largeflower gardenia, clove, rhizoma cyperi, radix kadsurea coccineae, herba centipedae, the root of three-nerved spicebush, Lobelia dauidii Franch. and radix aconiti preparata. The invention further provides the preparation method of the traditional Chinese medicinal composition for treating iron-deficiency anemia.

Description

A kind of Chinese medicine composition being used for the treatment of iron deficiency anemia and preparation method thereof
Technical field
The present invention relates to pharmaceutical sanitary field, be specifically related to a kind of Chinese medicine composition being used for the treatment of iron deficiency anemia and preparation method thereof.
Background technology
Iron deficiency anemia is the commonly encountered diseases in the whole world, and World Health Organization's investigation shows, in current crowd, iron deficiency anemia is still quite general.Whole world Anemic patients is more than 2,000,000,000, and wherein 50% belongs to iron deficiency anemia, reaches 20.1% at the average prevalence of anemia of China resident.
And at present domestic and international to prevention iron deficiency anemia research mainly lay particular emphasis on carry out in food ferrum interpolation strengthening with the intake improving ferrum, go to meet the needs of body to ferrum by various iron fortified food product, but practice shows that the absorbance of the ferrum in this based food is still lower, have because of the resting period comparatively of a specified duration, easily oxidized and affect sensory properties and the mouthfeel of food.Be that chalybeate based on Nu-Iron is treated to the treatment aspect of iron deficiency anemia, cause the reason of iron deficiency anemia more at present, and occurred frequently in child and female population.Therefore, in the traditional Chinese medical science, the treatment of iron deficiency anemia, except giving sufficient chalybeate, also should strengthen the factor of other each side, to promote that body is to the absorption of the ferrum element in food, thus effectively treat iron deficiency anemia.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition being used for the treatment of iron deficiency anemia;
Another object of the present invention is to provide a kind of preparation method being used for the treatment of the Chinese medicine composition of iron deficiency anemia.
The object of the invention is by following technical scheme realize:
The Chinese medicine composition being used for the treatment of iron deficiency anemia of the present invention, it is be prepared from by the raw material of following weight portion: Caulis et Folium hedyotis hedyotideae 70-82 part, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 70-82 part, Radix et Rhizoma Smilacis Ripariae 70-82 part, Radix Achyranthis Bidentatae 70-82 part, Radix seu Caulis Parabarii 70-82 part, GUIHUAFU 70-82 part, leaf of Radix Glycosmidis Citrifoliae 70-82 part, Herba Inulae cappae 70-82 part, Herba Artemisiae Anomalae 70-82 part, Caulis Bauhihiae Championii 70-82 part, Caulis et Folium Hyptidis suaveolentis 70-82 part, Radix Cudraniae 70-82 part, Radix Zanthoxyli 70-82 part, Caulis Spatholobi 70-82 part, Ramulus et Folium Claoxyli 70-82 part, Radix Solani indici 70-82 part, Radix Angelicae Pubescentis 70-82 part, Semen Impatientis 70-82 part, Fructus Gardeniae grandiflorae 70-82 part, Flos Caryophylli 35-42 part, Rhizoma Cyperi 135-170 part, kadsura root 135-170 part, Herba Centipedae 70-82 part, Radix Linderae 70-82 part, lobelia sessilifolia 70-82 part, Radix Aconiti Preparata 35-42 part, Camphora 2-5 part.
Preferably, it is be prepared from by the raw material of following weight portion: Caulis et Folium hedyotis hedyotideae 76 parts, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 76 parts, Radix et Rhizoma Smilacis Ripariae 76 parts, Radix Achyranthis Bidentatae 76 parts, Radix seu Caulis Parabarii 76 parts, GUIHUAFU 76 parts, leaf of Radix Glycosmidis Citrifoliae 76 parts, Herba Inulae cappae 76 parts, Herba Artemisiae Anomalae 76 parts, Caulis Bauhihiae Championii 76 parts, Caulis et Folium Hyptidis suaveolentis 76 parts, Radix Cudraniae 76 parts, Radix Zanthoxyli 76 parts, Caulis Spatholobi 76 parts, Ramulus et Folium Claoxyli 76 parts, Radix Solani indici 76 parts, Radix Angelicae Pubescentis 76 parts, Semen Impatientis 76 parts, Fructus Gardeniae grandiflorae 76 parts, Flos Caryophylli 38 parts, Rhizoma Cyperi 153 parts, kadsura root 153 parts, Herba Centipedae 76 parts, the Radix Linderae 76 parts, lobelia sessilifolia 76 parts, Radix Aconiti Preparata 38 parts, Camphora 3 parts.
Below crude drug source of the present invention:
Caulis et Folium hedyotis hedyotideae: this product is the dry rattan of Maguireothamnus speciosus Caulis et Folium hedyotis hedyotideae Hedyotishedyotidea (DC.) Merr..The whole year can adopt, and cleans, and section or section, dry.[nature and flavor with return through] are micro-sweet, cool.Return spleen, Liver Channel.[function with cure mainly] clearing away heat and expelling pathogen in the exterior, dispelling, collateral-activating, reducing swelling and alleviating pain.For cold, fever, limbs muscles and bones is ached, rheumatic arthralgia, traumatic injury.
Radix Piperis sarmentosi (Herba Piperis Sarmentosi): this product is the dry aerial parts of Piperaceae plant Radix Piperis sarmentosi (Herba Piperis Sarmentosi) PipersarmentosumRoxb..Tap when summer, autumn, plant strain growth was luxuriant, be bundled into wisp, dry.[nature and flavor] are pungent, temperature.[function with cure mainly] expelling wind and removing dampness, promoting flow of QI and blood, reducing swelling and alleviating pain, resolving phlegm and removing blood stasis.For traumatic injury, rheumatic ostalgia, the cold pain of stomach abdomen, dyspepsia abdominal distention, cough due to wind and cold.
Radix et Rhizoma Smilacis Ripariae: this product is the dry root machine rhizome of Smilacaceae plant Radix et Rhizoma Smilacis Ripariae SmilaxripariaA.DC..Summer, autumn excavate, and removing rattan and silt, dry.[nature and flavor] are sweet, bitter, flat.[function with cure mainly] channels sootheing and network vessel quickening, inrigorating qi and promoting blood circulation, expelling phlegm for arresting cough.For bones and muscles pain, deficiency of vital energy edema, traumatic injury, cough is spitted blood.
Radix Achyranthis Bidentatae: this product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae AchyranthesbidentataBl..Excavate when winter, stem and leaf was withered, removing fibrous root and silt, be bundled into wisp, shines as after wrinkle, trimmed on top, dry.[nature and flavor with return through] are bitter, sweet, sour, put down.Return liver, kidney channel.[function with cure mainly] eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.For amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, stranguria, edema, headache, dizzy, toothache, day skin ulcer, spit blood, epistaxis.
Radix seu Caulis Parabarii: this product is the dry bark of apocynaceae plant chun parabarium bark ParabariumchunianumTsiang, parabarium huaitingii Chun et Tsiang ParabariumhuaitingiiChunetTsiang, eucommia vine Parabariummicranthun (A.DC.) Pierre or flower hide glue rattan EcdysantherautilisHay.etKaw..The whole year can adopt, and strips bark, drying.[nature and flavor with return through] are bitter, puckery, micro-pungent, put down.[function with cure mainly] dispelling, collateral-activating, strong waist knee joint, bone and muscle strengthening, detumescence.For poliomyelitis, rheumatic ostalgia, traumatic injury.
GUIHUAFU: this product is the dry Herb of euphorbia plant Fruticose Breyniae Leaf and Twig Breyniafruticosa (L.) Hook.f..The whole year all can excavate, and removing silt, dries.[nature and flavor] micro-bitterness, cool; Slightly poisonous.[function with cure mainly] heat-clearing and toxic substances removing, eliminating stasis to stop pain, restrains antipruritic.For the heating of abnormal pigmentary deposit on the skin acute diseases such as cholera and sunstroke, headache, acute gastroenteritis, tonsillitis, puerperal uterine contraction pain, dysfunctional uterine hemorrhage, skin infection carbuncle, dermatitis rhus, skin eczema, allergic dermatitis, snakebite.
Leaf of Radix Glycosmidis Citrifoliae: this product is the dried leaves of rutaceae little Hua Radix Glycosmidis Citrifoliae Glycosmisparviflora (Sims) Kurz.[nature and flavor] are bitter, micro-pungent, flat.[function with cure mainly] dissipating blood stasis for subsidence of swelling, reduces phlegm, removing food stagnancy.For traumatic injury, cold cough, food stagnation distending pain.
Herba Inulae cappae: this product is the dry aerial parts of feverfew Herba Inulae cappae Inulacappa (Buch. ?Ham.) DC..Summer, autumn tap, removing impurity, dry.[nature and flavor] pungent, micro-hardship, temperature.Return lung, liver, stomach warp.[function with cure mainly] dispels the wind, dampness removing, promoting qi circulation, resolving food retention.For rheumatic arthritis, chest and diaphragm painful abdominal mass is vexed, malaria, and dysentery is had loose bowels, and puerperal catches a cold, hepatitis, hemorrhoid , Jie Xian.
Herba Artemisiae Anomalae: this product is the dry aerial parts of feverfew artemisia anomalas ArtemisiaanomalaS.Moore or Artemisia lactiflora Wall. ArtemisiaactifloraWall.ex.DC..Tap when summer, fall flowering, removing impurity, dries.[nature and flavor] micro-hardship, pungent, temperature.[function with cure mainly] promoting blood circulation to remove blood stasis, inducing menstruation to relieve menalgia, inducing diuresis and reducing edema, removing stagnancy of indigested food and relieving flatulence.For abdominalgia with blood stasis in puerperal, menoxenia, amenorrhea, dyspeptic abdominal distention, traumatic injury.
Caulis Bauhihiae Championii: this product is the dry rattan of Dou section Zhi Wu Caulis Endadae phaseoloidis Entadaphaseoloides (Linnaeus) Merrill.The whole year all can receive by Bian, cleans, cuts sheet, dry.[nature and flavor with return through] puckery, micro-hardship, cool.Slightly poisonous.Return liver, spleen channel.[function with cure mainly] expelling wind and removing dampness, blood circulation promoting competent silt.For rheumatic arthralgia, lumbago and skelalgia, treating swelling and pain by traumatic injury.
Caulis et Folium Hyptidis suaveolentis: this product is the dry herb of labiate Caulis et Folium Hyptidis suaveolentis Hyptissuaveolens (L.) Poit..Summer and autumn gathers, and removing impurity, dries in the shade.[nature and flavor] are pungent, bitter, flat.[function with cure mainly] dispelling wind dissipating blood stasis, circulation of qi promoting dampness removing, removing toxic substances, pain relieving.For headache due to common cold, flatulence, rheumatic ostalgia, treating swelling and pain by traumatic injury, wound hemorrhage, carbuncle sore tumefacting virus, worm venom, eczema, dermatitis.
Radix Cudraniae: this product is the dry root of moraceae plants cudrania cochinchinensis Cudraniacochinchinensis (Lour.) KudoetMasam..The whole year all can excavate, and removing fibrous root, cleans, section or section, to dry.[nature and flavor] micro-hardship, cool.[function with cure mainly] cough-relieving, jaundice eliminating, invigorates blood circulation, dredging collateral.For pulmonary tuberculosis, jaundice due to damp-heat, the pain over the hypochondriac region, falls and flutters stasis of blood pain, rheumatic arthralgia.
Radix Zanthoxyli: this product is the dry Herb of rutaceae Radix Zanthoxyli Zanthoxylumnitidum (Roxh.) DC.var.tomentosumHuang.The whole year all can gather, removing impurity, and section is dry.[nature and flavor] are pungent, bitter, temperature; Slightly poisonous.[function cures mainly] dispelling wind and removing obstruction in the collateral, reducing swelling and alleviating pain.For rheumatic ostalgia, sore throat, scrofula, stomachache, toothache, exanthema subitum, traumatic injury, burn and scald, venom.
Caulis Spatholobi: this product is the dry rattan of leguminous plant spatholobus suberectus SpatholobussuberectusDunn.Autumn, season in winter two gather, and removing branch and leaf, section, dries.[nature and flavor with return through] are bitter, sweet, temperature.Return liver, kidney channel.[function with cure mainly] blood circulation promoting and enriching, menstruction regulating and pain relieving, relaxing muscles and tendons and activating QI and blood in the collateral.For menoxenia, dysmenorrhea, amenorrhea, rheumatic arthralgia, paralysis and numbness, blood deficiency and yellow complexion.
Ramulus et Folium Claoxyli: this product is the dry zone leaf twig of euphorbia plant princess tree tree Claoxylonpulot (Burm.) Merr..The whole year all can gather, and dries.[nature and flavor] are light, flat; Slightly poisonous.[function with cure mainly] expelling wind and removing dampness, eliminating stasis to stop pain.For rheumatic arthralgia, wound stasis of blood pain.
Radix Solani indici: this product is the dry root of plant of Solanaceae Fructus Solani Khasiani SolanumindicumL. cattle Fructus Solani melongenae SolanumsurattenseBurm.f. Radix Solani Torvi SolanumtorvumSwartz. or Fructus solani xanthocarpi SolanumxanthocarpumSchrad.et.Wendl. and old stem.The whole year can adopt, and removing fibrous root, cleans, dry.[nature and flavor] pungent, micro-hardship, tepor.Slightly poisonous.[function with cure mainly] promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.For traumatic injury, lumbar muscle strain, stomachache, toothache, rheumatalgia, sore.
Radix Angelicae Pubescentis: this product is the dry root of samphire Angelica pubescens AngelicapubescensMaxim.f.biserrataShanetYuan.Excavate when Seedling at the beginning of spring has just germinateed or autumn Mo, stem and leaf was withered, removing fibrous root and silt, be dried to half-dried, bank up 2 ~ 3 days, be dried to absolutely dry after feeling like jelly again.[nature and flavor with return through] are pungent, bitter, tepor.Return kidney, urinary bladder channel.[function with cure mainly] expelling wind and removing dampness, numbness relieving and pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache wind and cold holds wet headache under the arm.
Semen Impatientis: this product is the dry mature seed of Balsaminaceae plant Flos Impatientis ImpatiensbalsaminaL..Summer, autumn gather when fruit is about to ripe, dry, removing peel and impurity.[nature and flavor with return through] micro-hardship, pungent, temperature; Slightly poisonous.Return lung, Liver Channel.[function with cure mainly] removing blood stasis softening the hard mass, removing food stagnancy.For note of the ancient Chinese abdominal mass mass in the abdomen, amenorrhea, dysphagic.
Fructus Gardeniae grandiflorae: this product is the dry mature fruit of Maguireothamnus speciosus Flos Caryophylli Fructus Gardeniae GardeniajasminoidesEllisvar.grandillora (Lour.) Nakai.Collecting fruit about October, cuts off the calyx head deposited place, dries or dry after drying or boiling.[nature and flavor] are bitter, cold.[function with cure mainly] subsides a swelling active.For controlling injury from falling down bruise, skin bruise pain.
Flos Caryophylli: this product is the dry flower of plant clove of myrtaceae EugeniacaryophyllataThunb..Pluck when alabastrum turns red by green, dry.[nature and flavor with return through] are pungent, temperature.Return spleen, stomach, lung, kidney channel.[function with cure mainly] warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.
Rhizoma Cyperi: this product is the dry rhizome of sedge dried tuber CyperusrotundusL..Autumn excavates, sing the hair must, put in boiling water after slightly boiling or steaming and dry, or burn and directly to dry afterwards.[nature and flavor with return through] pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.[function with cure mainly] dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea.
Kadsura root: this product is the dry root of Magnoliacea plant Kadsura coccinea (Lem.) A. C. Smith Kadsuracoccinea (Lem.) A.C.Smith.Record in " Chinese Pharmacopoeia " version in 1977.Or Caulis Piperis Kadsurae, the i.e. dry rattan of Kadsura heteroclita Kadsuraheteroclita (Roxb.) Craib, record in " Guangxi Chinese crude drug standard ".[nature and flavor] are sweet, micro-pungent, temperature.[function with cure mainly] expelling wind and cold, promoting the circulation of QI to relieve pain, relaxing muscles and tendons and activating QI and blood in the collateral.For rheumatic arthritis, lumbar muscle strain, flu, puerperal paralysis.
Herba Centipedae: this product is the dry herb of feverfew Herba Centipedae Centipedaminima (L.) A.Br.etAschers..Summer, autumn two gather when season, the flowers are in blossom, wash away silt, dry.[nature and flavor with return through] are pungent, temperature.Return lung meridian.[function with cure mainly] dispersing wind-cold, clearing the nasal passage, cough-relieving.For headche due to wind-cold, cough with copious phlegm, has a stuffy nose obstructed, nasal sinusitis watery nasal discharge.
The Radix Linderae: this product is the dried root of canella Radix Linderae Linderaaggregata (Sims) Kosterm..The whole year all can excavate, and removing radicula, cleans, take advantage of fresh slices, dry, or directly dry.[nature and flavor with return through] are pungent, temperature.Return lung, spleen, kidney, urinary bladder channel.[function with cure mainly] promoting the circulation of QI to relieve pain, warming kidney for dispelling cold.For QI stagnated by cold, chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia pain, through cold stomachache.
Lobelia sessilifolia: this product is the dry root stock of Begoniaceae plant thick beak Flos Begoniae Evansianae BegoniacrassirostrisIrmsch., Begonia pedatifida BegoniapalmataD.Don or Pharmacognostical Study BegoniapedatifidaLevl..The whole year can adopt, and takes root stock, removing fibrous root, cleaning, drying.[nature and flavor] are sour, puckery, cool.[function with cure mainly] heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For laryngopharynx swelling and pain, rheumatic ostalgia, treating swelling and pain by traumatic injury, toothache, venom, burn and scald.
Radix Aconiti Preparata: this product is this product is sheet that is irregular or Yangtze River Delta shape.Surface pitchy or yellowish-brown, have taupe brown cambium layer ring grain.Body is light, and matter is crisp, and section is glossy.Feeble QI, micro-have numb feeling in the tongue.[nature and flavor with return through] are pungent, bitter, heat; Poisonous.GUIXIN, liver,kidney,spleen warp.[function with cure mainly] expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain and narcotic analgesic.
Another aspect of the present invention there is provided the preparation method of the active component in the present invention, and the method is the ethanol extraction of employing 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Get whole raw material of Chinese medicine, with 40-80% ethanol ultrasonic extraction 2-3 time, each ethanol consumption be the 4-10 of medical material total amount doubly, extraction time is 1-3 hour, merge extractive liquid, and filter, filtrate is condensed into fluid extract, to obtain final product.
The Chinese medicine composition being used for the treatment of iron deficiency anemia described in invention, with pharmaceutically acceptable carrier combination, can make various common dosage forms, as tablet, granule, capsule, chewable tablet, pill etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: granule
Get the active component of gained, be dried to dried cream powder, mix homogeneously, add granule and commonly use adjuvant, production method is prepared into granule of the present invention routinely.
Above-mentioned granule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent or whole.
Method 2: tablet
Get the active component of gained, be dried to dried cream powder, mix homogeneously, add tablet and commonly use adjuvant, production method is prepared into Tablets routinely.
Above-mentioned tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: capsule
Get the active component of gained, be dried to dried cream powder, mix homogeneously, add capsule and commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
Above-mentioned capsule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, lubricant or whole.
Method 4: chewable tablet
Get the active component of gained, be dried to dried cream powder, mix homogeneously, add chewable tablet and commonly use adjuvant, production method is prepared into chewable tablet of the present invention routinely.
Above-mentioned chewable tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 5: pill
Get the active component of gained, be dried to dried cream powder, mix homogeneously, add pill and commonly use adjuvant, production method is prepared into pill of the present invention routinely.
Above-mentioned pill is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, lubricant or whole.
Fang Xie: in Chinese medicine, to belong to the categories such as " blood deficiency ", " sallow " " asthenia " in Chinese medicine according to clinical symptoms by iron deficiency anemia.Think according to Basic Theories of Chinese Medicine, the main blood of the heart, blood stored in the liver, the spleen governs the blood, kidney storing essence, therefore the functional disorder betiding the heart, spleen, liver, kidney of anemia, internal organs are deficient closely related.Main pathogenesis is weakness of the spleen and stomach, QI and blood deficiency, caused by liver and kidney deficiency etc.And reuse Radix et Rhizoma Smilacis Ripariae, the Radix Linderae in the present invention for monarch, Radix et Rhizoma Smilacis Ripariae sweet in the mouth, can put down filling blood, and can invigorate blood circulation again and soothing the channels and quicking the network vessels, especially we should control card; Radix Linderae Xin Kaiwen falls apart, kind dredging mechanism of qi, the male temperature of its gas, enters kidney channel and kind warming kidney for dispelling cold, can nourish body yang-energy with consolidating superficial resistance, enters spleen channel and QI invigorating warming the spleen alleviating distention in middle-JIAO, can help precise and tinyization life and rectify.Radix seu Caulis Parabarii can strengthen waist knee joint, bone and muscle strengthening, is the product of kidney invigorating and YANG supporting, can helps the gesture of Radix Linderae YANG invigorating; GUIHUAFU energy heat-clearing and toxic substances removing, helps Radix Linderae righting gas, the effect of blood-activating analgetic of holding concurrently again; Leaf of Radix Glycosmidis Citrifoliae enters Liver Channel and blood stasis dispersing and deswelling, and kind tune reaches blood vessels, vigorous blood; The effect of Herba Inulae cappae tool promoting the circulation of QI to relieve pain, again can tonify deficiency, and two arrogate to oneself its merit; Herba Artemisiae Anomalae function removing blood stasis stimulates the menstrual flow, eliminating stasis to stop pain, all cards of kind treatment blood stasis; Caulis Bauhihiae Championii merit is apt to blood circulation promoting competent silt, again can wind-damp dispelling, can the heresy of anti-rheumatism seize the opportunity body battalion defend inconsiderate and in invade; The effect of Radix Cudraniae tool blood circulation promoting and blood stasis dispelling, the merit of circulation of qi promoting of holding concurrently again; Radix Zanthoxyli acrid in the mouth is warm in nature, kind dispelling wind and removing obstruction in the collateral, reducing swelling and alleviating pain; Caulis Spatholobi merit is kind enriches blood, again can promoting the circulation of blood blood stasis dispelling, can the gesture of walk help monarch drug; Rhizoma Cyperi enters Liver Channel edema caused by disorder of QI, and its acrid in the mouth can fall apart, and bitter can receive, sweet energy and, especially kind regulating functional activities of qi, make the handsome blood of gas, blood vessels must be supported, and seek Wei get Gu, can invade in the heresy of anti-rheumatism, the effect of also double pain relieving.Below be all ministerial drug, principal drug assistance plays blood circulation promoting and blood stasis dispelling, the merit of warming YANG and invigorating QI.Fang Zhongzuo is with all medicines of Caulis et Folium hedyotis hedyotideae, Radix Achyranthis Bidentatae, Radix Angelicae Pubescentis, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Ramulus et Folium Claoxyli, Radix Solani indici, Semen Impatientis, Fructus Gardeniae grandiflorae, kadsura root, lobelia sessilifolia, Radix Aconiti Preparata, Herba Centipedae, Flos Caryophylli and Camphora.Caulis et Folium hedyotis hedyotideae merit benefaction blood and dissolving stasis, has again the effect of wind-damp dispelling, the effect of hemostasis held concurrently again, can all medicine promoting the circulation of blood of anti-we too and from through hemorrhage; Radix Piperis sarmentosi (Herba Piperis Sarmentosi) energy warming middle-JIAO to promote flow of QI, detumescence of dispeling the wind; Ramulus et Folium Claoxyli energy dissipating blood stasis, expelling wind and removing dampness; Radix Solani indici energy promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain; Semen Impatientis is apt to removing blood stasis softening the hard mass; Kadsura root acrid in the mouth, warm in nature, benefaction meridian qi and blood and replenishing vital QI with drugs of warm nature passages through which vital energy circulates; Fructus Gardeniae grandiflorae can be subsided a swelling active, has again a merit of heat clearing away; Lobelia sessilifolia is apt to heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Radix Aconiti Preparata function expelling wind and removing dampness, antalgic; Caulis et Folium Hyptidis suaveolentis is pungent cool, and gas is fragrant, dissipating blood stasis of both can having subsided a swelling, and tool induces sweat the effect of heat clearing away again, and its property is up; Radix Angelicae Pubescentis energy expelling wind and removing dampness, numbness relieving and pain relieving, induces sweat, and its property is also descending; Radix Achyranthis Bidentatae merit is apt to eliminating blood stasis and inducing menstruation, kind descending kidney yang of supplementing nutrition of igniting, and its property is also descending; Caulis et Folium Hyptidis suaveolentis, Radix Angelicae Pubescentis and Radix Achyranthis Bidentatae are the guiding drug of we.Herba Centipedae, Flos Caryophylli fragrant odour, be apt to take all medicine medicine gesture and walk to alter meridians.The all medicines of we share, and strengthen the system blood controlling nocturnal emission with astringent drugs effect of spleen kidney, function of spleen and stomach regulating function, makes mechanism of qi function be in harmonious proportion, thus play nourishing the liver and kidney, the effect of spleen invigorating QI invigorating.Finally help with the Fructus Sophorae, make the nature and flavor of perfect square tend to gentle, thus be beneficial to YIN and YANG balancing in body, be beneficial to and carry out long-term taking good care of with the present invention.
A kind of Chinese medicine composition being used for the treatment of iron deficiency anemia provided by the invention has the following advantages:
1, in prescription of the present invention, each medicine share, and jointly plays blood circulation promoting and blood stasis dispelling, kidney and spleen invigorating, the effect of the merit of relaxing muscles and tendons and activating QI and blood in the collateral, can play the effect for the treatment of iron deficiency anemia preferably.
2, RBC, Hb, Hct of taking embodiments of the invention group rat the increasing of degree all to some extent, obvious rise is all had compared with low ferrum group, and all have significant difference (P < 0.01), therefore this experiment can prove the present invention can have the effect for the treatment of iron deficiency anemia.
3, present composition formula is rationally innovated, and production cost is low, technique is simple.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.
Embodiment 1
Get Caulis et Folium hedyotis hedyotideae 70g, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 70g, Radix et Rhizoma Smilacis Ripariae 70g, Radix Achyranthis Bidentatae 70g, Radix seu Caulis Parabarii 70g, GUIHUAFU 70g, leaf of Radix Glycosmidis Citrifoliae 70g, Herba Inulae cappae 70g, Herba Artemisiae Anomalae 70g, Caulis Bauhihiae Championii 70g, Caulis et Folium Hyptidis suaveolentis 70g, Radix Cudraniae 70g, Radix Zanthoxyli 70g, Caulis Spatholobi 70g, Ramulus et Folium Claoxyli 70g, Radix Solani indici 70g, Radix Angelicae Pubescentis 70g, Semen Impatientis 70g, Fructus Gardeniae grandiflorae 70g, Flos Caryophylli 35g, Rhizoma Cyperi 135g, kadsura root 135g, Herba Centipedae 70g, Radix Linderae 70g, lobelia sessilifolia 70g, Radix Aconiti Preparata 35g, with 40% ethanol ultrasonic extraction 2 times, each ethanol consumption is 4 times of medical material total amount, extraction time is 1 hour, merge extractive liquid, filter, filtrate is condensed into fluid extract, be dried to dried cream powder, pulverize, add adjuvant xylitol again, mannitol, magnesium stearate makes chewable tablet.
Embodiment 2
Get Caulis et Folium hedyotis hedyotideae 82g, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 82g, Radix et Rhizoma Smilacis Ripariae 82g, Radix Achyranthis Bidentatae 82g, Radix seu Caulis Parabarii 82g, GUIHUAFU 82g, leaf of Radix Glycosmidis Citrifoliae 82g, Herba Inulae cappae 82g, Herba Artemisiae Anomalae 82g, Caulis Bauhihiae Championii 82g, Caulis et Folium Hyptidis suaveolentis 82g, Radix Cudraniae 82g, Radix Zanthoxyli 82g, Caulis Spatholobi 82g, Ramulus et Folium Claoxyli 82g, Radix Solani indici 82g, Radix Angelicae Pubescentis 82g, Semen Impatientis 82g, Fructus Gardeniae grandiflorae 82g, Flos Caryophylli 42g, Rhizoma Cyperi 170g, kadsura root 170g, Herba Centipedae 82g, Radix Linderae 82g, lobelia sessilifolia 82g, Radix Aconiti Preparata 42g, with 80% ethanol ultrasonic extraction 3 times, each ethanol consumption is 10 times of medical material total amount, extraction time is 3 hours, merge extractive liquid, filter, filtrate is condensed into fluid extract, be dried to dried cream powder, pulverize, add supplementary product starch, cane sugar powder, Pulvis Talci, magnesium stearate, obtained granule.
Embodiment 3
Get Caulis et Folium hedyotis hedyotideae 76g, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 76g, Radix et Rhizoma Smilacis Ripariae 76g, Radix Achyranthis Bidentatae 76g, Radix seu Caulis Parabarii 76g, GUIHUAFU 76g, leaf of Radix Glycosmidis Citrifoliae 76g, Herba Inulae cappae 76g, Herba Artemisiae Anomalae 76g, Caulis Bauhihiae Championii 76g, Caulis et Folium Hyptidis suaveolentis 76g, Radix Cudraniae 76g, Radix Zanthoxyli 76g, Caulis Spatholobi 76g, Ramulus et Folium Claoxyli 76g, Radix Solani indici 76g, Radix Angelicae Pubescentis 76g, Semen Impatientis 76g, Fructus Gardeniae grandiflorae 76g, Flos Caryophylli 38g, Rhizoma Cyperi 153g, kadsura root 153g, Herba Centipedae 76g, Radix Linderae 76g, lobelia sessilifolia 76g, Radix Aconiti Preparata 38g, with 50% ethanol ultrasonic extraction 3 times, each ethanol consumption is 7 times of medical material total amount, extraction time is 2 hours, merge extractive liquid, filter, filtrate is condensed into fluid extract, be dried to dried cream powder, pulverize, add microcrystalline cellulose excipients again, hydroxypropyl cellulose, carboxymethyl starch sodium, Pulvis Talci, magnesium stearate makes tablet.
Pharmacodynamics test:
1 experiment material
1.1 animal
Cleaning grade SD female rats, body weight 130 ~ 150g, is provided by the western pul in Shanghai-Bi Kai laboratory animal company limited, credit number SCXK (Shanghai) 2003-0002.
1.2 given the test agent and reagent
1.2.1 the embodiment of the present invention 1 ~ 3.
1.2.2 low ferrum feedstuff:
Low ferrum feed formula as table 1, AIN-93G mixed mineral salt formula in table 2, AIN -93Gmixed vitamin formula is in table 3.
Table 1 low ferrum forage compounding table
Table 2AIN-93G mixed mineral salt formula
Table 3AIN -93Gmixed vitamin formula
2 experiment grouping and medications
2.1 be respectively blank group, low ferrum matched group, embodiment 1 ~ 3 group.
2.2 dosages:
2.2.1 blank group, low ferrum matched group: give pure water, gavage volume is 10ml/kg.
2.2.2 each group of embodiment: mice give respectively embodiment 1 ~ 3 prepare sample, dosage by medical material crude drug amount 304g/kg, every day gavage 1 time, gavage volume is 10ml/kg.
2.3 medications: every day gavage 1 time, continuous 30d.
3 experimental techniques
Foundation and the laboratory observation of 3.1 rat iron-deficiency anemia model get rat, and docking is got blood and surveyed each animal erythrocyte number (RBC), red cell morphology, hematochrome (Hb) and packed cell volume (Hct) as normal value before modeling.Random taking-up 10, as blank group, feeds with normal normal diet.All the other rats iron deficiency anemia feedstuff be prepared from by the formula in 1.2.2 is fed, and is aided with every 3 days and puts tail blood 1 time.Each blood-letting 1ml, altogether blood-letting 3 times.After 20 days, when detecting rat Hb major part lower than 90g/L, i.e. modeling success.By successful for modeling rat, Hb, 90g/L and following rat, is divided into 5 groups at random, often organizes 10, compiles respectively as low ferrum matched group, embodiment 1 ~ 3 group.Blank group and low ferrum matched group give pure water respectively, other 3 groups amount administrations of pressing 2.2.2 respectively.Successive administration 30 days.Normal and animal pattern still continues to give normal diet and low ferrum forage feed respectively.Observe the ordinary circumstance change after animals administer.Next day after last administration, blood is got in docking, measures Hb, RBC, Hct and detects.
The whole measurement data of 3.2 statistical procedures the data obtained all with represent.Statistical analysis adopts SPSS11.5 statistical software to process.Compare between group and check with t after homogeneity of variance analysis.
4. experimental result
4.1 impacts on animal general status and body weight, food-intake
In animal model process, animal engenders asthenia, movable minimizing, and declining appears in body weight, and the Anemias such as food-intake reduces, eyeball is pale, have a small amount of animal dead after modeling process.After grouping, the above-mentioned symptom sustainable existence of low ferrum matched group also worsens further.And the Anemia having taken rat of the present invention starts to take effect after one week in administration, Anemia improves, the general status of administration animal after 30 days, outward appearance activity and behavior and hair color recover gradually even close to blank group level, and body weight and food-intake be obvious increase compared with model group.
4.2 respectively organize erythrocyte and hematochrome results contrast: the results are shown in Table 4.
Table 4 the present invention is on the impact of Rat Erythrocytes and hematochrome
Note: compared with blank group: * P < 0.05, * * P < 0.01; Compare with low ferrum group: #p < 0.05, ##p < 0.01
Table 4 result shows: in modeling after 20 days, RBC, Hb, Hct of rat, and decline (P < 0.01) compared with blank group equal significance, prompting modeling success.After modeling success, take RBC, Hb, Hct of embodiments of the invention group rat, all have obvious rise compared with low ferrum group, and all have significant difference (P < 0.01).Although compared with blank group, also there is difference, but because the drug effect of Chinese medicine is slower, and experimental data shows that the phenomenon that RBC, Hb, Hct of causing due to iron deficiency anemia are low has been stopped, and go up with starting significance, therefore this experiment can prove the present invention can have the effect for the treatment of iron deficiency anemia.
Conclusion: research shows, the general status of Binding experiment rat and hemogram checking, can prove that the present invention has the effect for the treatment of iron deficiency anemia, in process of the test there is not other obvious side effect in rat simultaneously, so can prove the present invention have action temperature and, be effectively applicable to many people.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims (5)

1. one kind is used for the treatment of the Chinese medicine composition of iron deficiency anemia, it is characterized in that it is prepared from by the raw material of following weight portion: Caulis et Folium hedyotis hedyotideae 70-82 part, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 70-82 part, Radix et Rhizoma Smilacis Ripariae 70-82 part, Radix Achyranthis Bidentatae 70-82 part, Radix seu Caulis Parabarii 70-82 part, GUIHUAFU 70-82 part, leaf of Radix Glycosmidis Citrifoliae 70-82 part, Herba Inulae cappae 70-82 part, Herba Artemisiae Anomalae 70-82 part, Caulis Bauhihiae Championii 70-82 part, Caulis et Folium Hyptidis suaveolentis 70-82 part, Radix Cudraniae 70-82 part, Radix Zanthoxyli 70-82 part, Caulis Spatholobi 70-82 part, Ramulus et Folium Claoxyli 70-82 part, Radix Solani indici 70-82 part, Radix Angelicae Pubescentis 70-82 part, Semen Impatientis 70-82 part, Fructus Gardeniae grandiflorae 70-82 part, Flos Caryophylli 35-42 part, Rhizoma Cyperi 135-170 part, kadsura root 135-170 part, Herba Centipedae 70-82 part, Radix Linderae 70-82 part, lobelia sessilifolia 70-82 part, Radix Aconiti Preparata 35-42 part.
2. be used for the treatment of the Chinese medicine composition of iron deficiency anemia as claimed in claim 1, it is characterized in that it is prepared from by the raw material of following weight portion: Caulis et Folium hedyotis hedyotideae 76 parts, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 76 parts, Radix et Rhizoma Smilacis Ripariae 76 parts, Radix Achyranthis Bidentatae 76 parts, Radix seu Caulis Parabarii 76 parts, GUIHUAFU 76 parts, leaf of Radix Glycosmidis Citrifoliae 76 parts, Herba Inulae cappae 76 parts, Herba Artemisiae Anomalae 76 parts, Caulis Bauhihiae Championii 76 parts, Caulis et Folium Hyptidis suaveolentis 76 parts, Radix Cudraniae 76 parts, Radix Zanthoxyli 76 parts, Caulis Spatholobi 76 parts, Ramulus et Folium Claoxyli 76 parts, Radix Solani indici 76 parts, Radix Angelicae Pubescentis 76 parts, Semen Impatientis 76 parts, Fructus Gardeniae grandiflorae 76 parts, Flos Caryophylli 38 parts, Rhizoma Cyperi 153 parts, kadsura root 153 parts, Herba Centipedae 76 parts, the Radix Linderae 76 parts, lobelia sessilifolia 76 parts, Radix Aconiti Preparata 38 parts.
3. be used for the treatment of the Chinese medicine composition of iron deficiency anemia as claimed in claim 1 or 2, it is characterized in that its active component is the ethanol extraction of employing 40-80% concentration expressed in percentage by volume, Camphora is ground into fine powder and adds and be prepared from.
4. be used for the treatment of the Chinese medicine composition of iron deficiency anemia as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole raw material of Chinese medicine, with 40-80% ethanol ultrasonic extraction 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-3 hour, merge extractive liquid, filters, filtrate is condensed into fluid extract, to obtain final product.
5. be used for the treatment of a Chinese medicine preparation for iron deficiency anemia, prepared by acceptable carrier in the Chinese medicine composition being used for the treatment of iron deficiency anemia described in claim 1 or 2 and pharmaceuticals industry and form.
CN201610096293.7A 2016-02-22 2016-02-22 Traditional Chinese medicinal composition for treating iron-deficiency anemia and preparation method of traditional Chinese medicinal composition Pending CN105521226A (en)

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Application publication date: 20160427