CN105521225A

CN105521225A - Traditional Chinese medicinal composition for boosting immunity and preparation method of traditional Chinese medicinal composition

Info

Publication number: CN105521225A
Application number: CN201610096229.9A
Authority: CN
Inventors: 郑志远; 吴赛春; 钟杰敏; 邓裕彦; 黄源春; 李柏霖; 杨北妮; 林艳英
Original assignee: Guangxi Wuzhou Pharmaceutical Group Co Ltd
Current assignee: Guangxi Wuzhou Pharmaceutical Group Co Ltd
Priority date: 2016-02-22
Filing date: 2016-02-22
Publication date: 2016-04-27

Abstract

The invention discloses a traditional Chinese medicinal composition for boosting the immunity and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition is prepared from the following raw materials: herba hedyotideae, sarmentose pepper herb, the root and rhizome of ripqrian greenbrier, radix achyranthis bidentatae, the root or stem of smallflower parabarium, fruticose breyniae leaf and twig, the leaf of Hongkong kumquat, sheepear inula herb, diverse wormwood herb, the vines and kernels of Entada phaseoloides (L.) Merr., hyptis suaveolens, Cudrania cochinchinensis Kudo et Masam, Zanthoxylum nitidum var.fastuosum, suberect spatholobus stem, the twig and leaf of common claoxylon, the root of Solanum surattense Burm. f., radix angelicae pubescentis, the seeds of garden balsam, the fruits of largeflower gardenia, clove, rhizoma cyperi, radix kadsurea coccineae, herba centipedae, the root of three-nerved spicebush, Lobelia dauidii Franch., radix aconiti preparata and camphor. After a mouse takes the traditional Chinese medicinal composition, the DTH capacity is obviously improved; the contents of IL-2, TNF-alpha and IFN-gamma in the serum of the mouse are obviously reduced; the contents of IL-2, TNF-alpha and IFN-gamma in the levomisole group and the embodiment groups are obviously improved, and the differences are significant; the swelling degree of the vola pedis is obviously improved, and the traditional Chinese medicinal composition has the function of boosting the immunity of the mouse.

Description

A kind of Chinese medicine composition for enhancing immunity and preparation method thereof

Technical field

The present invention relates to pharmaceutical sanitary field, be specifically related to a kind of Chinese medicine composition for enhancing immunity and preparation method thereof.

Background technology

Immune system is the defence network covering whole body, the first line of defence of protection health.Immune system (immunologicfunction) is the protection capability that living organism progressively obtains in phyletic evolution and ontogenetic process.Mainly comprise three aspects: body resists the immune protection function of extraneous infectious; Body removes damage and dead cell, maintains the homeostatic function of own physiological balance; Body is monitored, finds and remove the immune surveillance function of mutant cell.Under normal physiological conditions, the immune system of body relies on its congenital immunocompetence of having and acquired immunocompetence to play co-immunization effect, keeps the physiological function of body relatively stable.If immunologic function occurs abnormal, the imbalance of body physiological function will inevitably be caused, thus occur that pathologic changes.And theory of Chinese medical science thinks that all paathogenic factors are pathogen, all resistances against diseases are healthy energy.Healthy energy, is divided into again the qi of zang-fu viscera etc. defending gas, vigour and Main Tissues organ.It is to play the healthy energy that defence exopathogen invades human body that what is called defends gas.If healthy energy is vigorous, body just can eliminating evilly be gone out, and avoids sick, i.e. so-called " healthy energy internal memory, heresy can not be done ".If the positive deficiency of vital energy declines, then pathogen easily invades body and causes disease, and namely so-called causing a disease is due to " beating of heresy, its gas must be empty ".Therefore the strengthening vital QI to eliminate pathogenic factors that proposes in the process of preventing and curing diseases of the traditional Chinese medical science is with the basic principle consolidated, and is consistent with the health-care method of enhancing human body immunity power.

Chinese patent application CN03111699.X is open a kind of by Herba Ephedrae, Ramulus Cinnamomi, Flos Magnoliae, Herba Spirodelae, the Rhizoma Anemarrhenae, Radix Scrophulariae, Bulbus Allii Macrostemonis, the Radix Linderae, Rhizoma Cynanchi Stauntonii, Pumex, Semen Armeniacae Amarum, Radix Asteris, the Radix Stemonae, Caulis Polygoni Multiflori, Pollen Typhae, Rhizoma Chuanxiong, Olibanum, Flos Tulipae Gesnerianae, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Flos Carthami, Rhizoma Drynariae, Radix Scutellariae, Cortex Magnoliae Officinalis, Fructus Piperis Longi, Pericarpium Arecae, Fructus Chebulae, Radix Bupleuri, Flos Chrysanthemi, Spica Prunellae, Concha Ostreae, Aspongopus, Fructus Citri Sarcodactylis, Concha Haliotidis, Herba Apocyni veneti, Rhizoma Cyperi, Herba Pogostemonis, Herba Eupatorii, Rhizoma Atractylodis, Fructus Amomi, Semen Alpiniae Katsumadai, Fructus Ligustri Lucidi, Rhizoma Curculiginis, Semen Cuscutae, Actinolitum, Fructus Psoraleae, Polyporus, the Chinese medicine composition of Rhizoma Alismatis composition, be used for the treatment of heart disease, pulmonary heart disease, hepatopathy, gastropathy, the splenopathy, intestinal is sick, nephropathy, the urinary bladder disease, gynaecopathia, headache, skelalgia, lumbago, cervical vertebra pain, and improve the immunity of human body.

Open a kind of powerful raising immunity plaster of Chinese patent application CN200710114135.0 and preparation method thereof, medicine forms: principal agent comprises Rhizoma Coptidis, Radix Scutellariae, Rhizoma Zingiberis, Cortex Phellodendri, Radix Aconiti Lateralis Preparata, each 50-75g of Fructus Piperis etc., accessory drugs comprises three parts, Part I is Flos Caryophylli, each 30g-50g of Borneolum Syntheticum etc., Part II is Olibanum, Myrrha, Flos Caryophylli, Fructus Zanthoxyli (processed), Fructus Amomi, Fructus Aurantii Immaturus, each 70-100g of Pericarpium Citri Reticulatae Viride etc., and Part III is Sal Ammoniacus, each 100g-130g of Resina Ferulae etc.Its preparation method is: first soaked by principal agent stand oil, oil squeezes, natural cooling, then filtering medicinal residues again, evenly to fall back interior immersion with the abundant chemical combination of Plumbum preparatium; By stand-by for accessory drugs Part I levigation; By stand-by for accessory drugs Part II levigation; Accessory drugs Part III is put into water slow fire boil medicine, pour in accessory drugs Part II levigation after the medicine soup of acquisition is concentrated and stir, drying rear pulverizing is that powder is for subsequent use; Ointment is heated, then with Part I levigation, dry rear powder pulverized powder and mix in proportion, be immune plaster.

Chinese patent application CN200910079060.6 discloses a kind of by the Radix Astragali, Radix Panacis Quinquefolii, Fructus Jujubae, the molecular Chinese medicine composition of Fructus Lycii and preparation method thereof, and its proportioning is: Radix Astragali 10-150 part, Radix Panacis Quinquefolii 15-100 part, Fructus Jujubae 50-300 part, Fructus Lycii 10-200 part.There is effect of enhancing immunity.

Chinese patent application CN201310113534.0 is open a kind of with Rhizoma Cyperi (processed), Herba Asari, the Radix Linderae, Fructus Piperis Longi, Herba Pogostemonis, Radix Bupleuri, Herba Schizonepetae, Fructus Amomi, Herba Menthae, Flos Caryophylli, Pericarpium Citri Reticulatae processed, Fructus Amomi Rotundus, Radix Angelicae Pubescentis, Radix Glycyrrhizae, Rhizoma Chuanxiong (processed), Radix Trichosanthis, Folium Perillae, Rhizoma Gastrodiae, the Radix Angelicae Dahuricae, Lignum Santali Albi, Rhizoma Pinelliae Preparatum and this 22 taste Chinese medicine of Radix Saposhnikoviae are that raw material is aided with Cinnabaris, Borneolum Syntheticum, Chinese medicine composition prepared by Realgar and preparation method thereof, its drug ratio is: Rhizoma Cyperi (processed) 20-30 part, Herba Asari 4-8 part, Radix Linderae 20-30 part, Fructus Piperis Longi 4-8 part, Herba Pogostemonis 20-30 part, Radix Bupleuri 20-30 part, Herba Schizonepetae 20-30 part, Fructus Amomi 5-15 part, Herba Menthae 20-30 part, Flos Caryophylli 5-15 part, Pericarpium Citri Reticulatae 20-30 part processed, Fructus Amomi Rotundus 3-6 part, Radix Angelicae Pubescentis 10-15 part, Radix Glycyrrhizae 3-6 part, Rhizoma Chuanxiong (processed) 10-15 part, Radix Trichosanthis 3-6 part, Folium Perillae 15-20 part, Rhizoma Gastrodiae 10-15 part, Radix Angelicae Dahuricae 30-40 part, Lignum Santali Albi 25-35 part, Rhizoma Pinelliae Preparatum 10-20 part, Radix Saposhnikoviae 25-35 part, Cinnabaris 10-15 part, Borneolum Syntheticum 4-8 part and Realgar 4-8 part.Be used for the treatment of and have a delicate constitution, enhancing immunity.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for enhancing immunity;

Another object of the present invention is to provide a kind of preparation method of the Chinese medicine composition for enhancing immunity.

The object of the invention is by following technical scheme realize:

Chinese medicine composition for enhancing immunity of the present invention, it is be prepared from by the raw material of Chinese medicine of following weight portion: Caulis et Folium hedyotis hedyotideae 70-82 part, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 70-82 part, Radix et Rhizoma Smilacis Ripariae 70-82 part, Radix Achyranthis Bidentatae 70-82 part, Radix seu Caulis Parabarii 70-82 part, GUIHUAFU 70-82 part, leaf of Radix Glycosmidis Citrifoliae 70-82 part, Herba Inulae cappae 70-82 part, Herba Artemisiae Anomalae 70-82 part, Caulis Bauhihiae Championii 70-82 part, Caulis et Folium Hyptidis suaveolentis 70-82 part, Radix Cudraniae 70-82 part, Radix Zanthoxyli 70-82 part, Caulis Spatholobi 70-82 part, Ramulus et Folium Claoxyli 70-82 part, Radix Solani indici 70-82 part, Radix Angelicae Pubescentis 70-82 part, Semen Impatientis 70-82 part, Fructus Gardeniae grandiflorae 70-82 part, Flos Caryophylli 35-42 part, Rhizoma Cyperi 135-170 part, kadsura root 135-170 part, Herba Centipedae 70-82 part, Radix Linderae 70-82 part, lobelia sessilifolia 70-82 part, Radix Aconiti Preparata 35-42 part, Camphora 2-5 part.

Preferably, it is be prepared from by the raw material of Chinese medicine of following weight portion: Caulis et Folium hedyotis hedyotideae 76 parts, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 76 parts, Radix et Rhizoma Smilacis Ripariae 76 parts, Radix Achyranthis Bidentatae 76 parts, Radix seu Caulis Parabarii 76 parts, GUIHUAFU 76 parts, leaf of Radix Glycosmidis Citrifoliae 76 parts, Herba Inulae cappae 76 parts, Herba Artemisiae Anomalae 76 parts, Caulis Bauhihiae Championii 76 parts, Caulis et Folium Hyptidis suaveolentis 76 parts, Radix Cudraniae 76 parts, Radix Zanthoxyli 76 parts, Caulis Spatholobi 76 parts, Ramulus et Folium Claoxyli 76 parts, Radix Solani indici 76 parts, Radix Angelicae Pubescentis 76 parts, Semen Impatientis 76 parts, Fructus Gardeniae grandiflorae 76 parts, Flos Caryophylli 38 parts, Rhizoma Cyperi 153 parts, kadsura root 153 parts, Herba Centipedae 76 parts, the Radix Linderae 76 parts, lobelia sessilifolia 76 parts, Radix Aconiti Preparata 38 parts, Camphora 3 parts.

Below crude drug source of the present invention:

Caulis et Folium hedyotis hedyotideae: this product is the dry rattan of Maguireothamnus speciosus Caulis et Folium hedyotis hedyotideae Hedyotishedyotidea (DC.) Merr..The whole year can adopt, and cleans, and section or section, dry.[nature and flavor with return through] are micro-sweet, cool.Return spleen, Liver Channel.[function with cure mainly] clearing away heat and expelling pathogen in the exterior, dispelling, collateral-activating, reducing swelling and alleviating pain.For cold, fever, limbs muscles and bones is ached, rheumatic arthralgia, traumatic injury.

Radix Piperis sarmentosi (Herba Piperis Sarmentosi): this product is the dry aerial parts of Piperaceae plant Radix Piperis sarmentosi (Herba Piperis Sarmentosi) PipersarmentosumRoxb..Tap when summer, autumn, plant strain growth was luxuriant, be bundled into wisp, dry.[nature and flavor] are pungent, temperature.[function with cure mainly] expelling wind and removing dampness, promoting flow of QI and blood, reducing swelling and alleviating pain, resolving phlegm and removing blood stasis.For traumatic injury, rheumatic ostalgia, the cold pain of stomach abdomen, dyspepsia abdominal distention, cough due to wind and cold.

Radix et Rhizoma Smilacis Ripariae: this product is the dry root machine rhizome of Smilacaceae plant Radix et Rhizoma Smilacis Ripariae SmilaxripariaA.DC..Summer, autumn excavate, and removing rattan and silt, dry.[nature and flavor] are sweet, bitter, flat.[function with cure mainly] channels sootheing and network vessel quickening, inrigorating qi and promoting blood circulation, expelling phlegm for arresting cough.For bones and muscles pain, deficiency of vital energy edema, traumatic injury, cough is spitted blood.

Radix Achyranthis Bidentatae: this product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae AchyranthesbidentataBl..Excavate when winter, stem and leaf was withered, removing fibrous root and silt, be bundled into wisp, shines as after wrinkle, trimmed on top, dry.[nature and flavor with return through] are bitter, sweet, sour, put down.Return liver, kidney channel.[function with cure mainly] eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.For amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, stranguria, edema, headache, dizzy, toothache, day skin ulcer, spit blood, epistaxis.

Radix seu Caulis Parabarii: this product is the dry bark of apocynaceae plant chun parabarium bark ParabariumchunianumTsiang, parabarium huaitingii Chun et Tsiang ParabariumhuaitingiiChunetTsiang, eucommia vine Parabariummicranthun (A.DC.) Pierre or flower hide glue rattan EcdysantherautilisHay.etKaw..The whole year can adopt, and strips bark, drying.[nature and flavor with return through] are bitter, puckery, micro-pungent, put down.[function with cure mainly] dispelling, collateral-activating, strong waist knee joint, bone and muscle strengthening, detumescence.For poliomyelitis, rheumatic ostalgia, traumatic injury.

GUIHUAFU: this product is the dry Herb of euphorbia plant Fruticose Breyniae Leaf and Twig Breyniafruticosa (L.) Hook.f..The whole year all can excavate, and removing silt, dries.[nature and flavor] micro-bitterness, cool; Slightly poisonous.[function with cure mainly] heat-clearing and toxic substances removing, eliminating stasis to stop pain, restrains antipruritic.For the heating of abnormal pigmentary deposit on the skin acute diseases such as cholera and sunstroke, headache, acute gastroenteritis, tonsillitis, puerperal uterine contraction pain, dysfunctional uterine hemorrhage, skin infection carbuncle, dermatitis rhus, skin eczema, allergic dermatitis, snakebite.

Leaf of Radix Glycosmidis Citrifoliae: this product is the dried leaves of rutaceae little Hua Radix Glycosmidis Citrifoliae Glycosmisparviflora (Sims) Kurz.[nature and flavor] are bitter, micro-pungent, flat.[function with cure mainly] dissipating blood stasis for subsidence of swelling, reduces phlegm, removing food stagnancy.For traumatic injury, cold cough, food stagnation distending pain.

Herba Inulae cappae: this product is the dry aerial parts of feverfew Herba Inulae cappae Inulacappa (Buch. ?Ham.) DC..Summer, autumn tap, removing impurity, dry.[nature and flavor] pungent, micro-hardship, temperature.Return lung, liver, stomach warp.[function with cure mainly] dispels the wind, dampness removing, promoting qi circulation, resolving food retention.For rheumatic arthritis, chest and diaphragm painful abdominal mass is vexed, malaria, and dysentery is had loose bowels, and puerperal catches a cold, hepatitis, hemorrhoid ， Jie Xian.

Herba Artemisiae Anomalae: this product is the dry aerial parts of feverfew artemisia anomalas ArtemisiaanomalaS.Moore or Artemisia lactiflora Wall. ArtemisiaactifloraWall.ex.DC..Tap when summer, fall flowering, removing impurity, dries.[nature and flavor] micro-hardship, pungent, temperature.[function with cure mainly] promoting blood circulation to remove blood stasis, inducing menstruation to relieve menalgia, inducing diuresis and reducing edema, removing stagnancy of indigested food and relieving flatulence.For abdominalgia with blood stasis in puerperal, menoxenia, amenorrhea, dyspeptic abdominal distention, traumatic injury.

Caulis Bauhihiae Championii: this product is the dry rattan of Dou section Zhi Wu Caulis Endadae phaseoloidis Entadaphaseoloides (Linnaeus) Merrill.The whole year all can receive by Bian, cleans, cuts sheet, dry.[nature and flavor with return through] puckery, micro-hardship, cool.Slightly poisonous.Return liver, spleen channel.[function with cure mainly] expelling wind and removing dampness, blood circulation promoting competent silt.For rheumatic arthralgia, lumbago and skelalgia, treating swelling and pain by traumatic injury.

Caulis et Folium Hyptidis suaveolentis: this product is the dry herb of labiate Caulis et Folium Hyptidis suaveolentis Hyptissuaveolens (L.) Poit..Summer and autumn gathers, and removing impurity, dries in the shade.[nature and flavor] are pungent, bitter, flat.[function with cure mainly] dispelling wind dissipating blood stasis, circulation of qi promoting dampness removing, removing toxic substances, pain relieving.For headache due to common cold, flatulence, rheumatic ostalgia, treating swelling and pain by traumatic injury, wound hemorrhage, carbuncle sore tumefacting virus, worm venom, eczema, dermatitis.

Radix Cudraniae: this product is the dry root of moraceae plants cudrania cochinchinensis Cudraniacochinchinensis (Lour.) KudoetMasam..The whole year all can excavate, and removing fibrous root, cleans, section or section, to dry.[nature and flavor] micro-hardship, cool.[function with cure mainly] cough-relieving, jaundice eliminating, invigorates blood circulation, dredging collateral.For pulmonary tuberculosis, jaundice due to damp-heat, the pain over the hypochondriac region, falls and flutters stasis of blood pain, rheumatic arthralgia.

Radix Zanthoxyli: this product is the dry Herb of rutaceae Radix Zanthoxyli Zanthoxylumnitidum (Roxh.) DC.var.tomentosumHuang.The whole year all can gather, removing impurity, and section is dry.[nature and flavor] are pungent, bitter, temperature; Slightly poisonous.[function cures mainly] dispelling wind and removing obstruction in the collateral, reducing swelling and alleviating pain.For rheumatic ostalgia, sore throat, scrofula, stomachache, toothache, exanthema subitum, traumatic injury, burn and scald, venom.

Caulis Spatholobi: this product is the dry rattan of leguminous plant spatholobus suberectus SpatholobussuberectusDunn.Autumn, season in winter two gather, and removing branch and leaf, section, dries.[nature and flavor with return through] are bitter, sweet, temperature.Return liver, kidney channel.[function with cure mainly] blood circulation promoting and enriching, menstruction regulating and pain relieving, relaxing muscles and tendons and activating QI and blood in the collateral.For menoxenia, dysmenorrhea, amenorrhea, rheumatic arthralgia, paralysis and numbness, blood deficiency and yellow complexion.

Ramulus et Folium Claoxyli: this product is the dry zone leaf twig of euphorbia plant princess tree tree Claoxylonpulot (Burm.) Merr..The whole year all can gather, and dries.[nature and flavor] are light, flat; Slightly poisonous.[function with cure mainly] expelling wind and removing dampness, eliminating stasis to stop pain.For rheumatic arthralgia, wound stasis of blood pain.

Radix Solani indici: this product is the dry root of plant of Solanaceae Fructus Solani Khasiani SolanumindicumL. cattle Fructus Solani melongenae SolanumsurattenseBurm.f. Radix Solani Torvi SolanumtorvumSwartz. or Fructus solani xanthocarpi SolanumxanthocarpumSchrad.et.Wendl. and old stem.The whole year can adopt, and removing fibrous root, cleans, dry.[nature and flavor] pungent, micro-hardship, tepor.Slightly poisonous.[function with cure mainly] promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.For traumatic injury, lumbar muscle strain, stomachache, toothache, rheumatalgia, sore.

Radix Angelicae Pubescentis: this product is the dry root of samphire Angelica pubescens AngelicapubescensMaxim.f.biserrataShanetYuan.Excavate when Seedling at the beginning of spring has just germinateed or autumn Mo, stem and leaf was withered, removing fibrous root and silt, be dried to half-dried, bank up 2 ~ 3 days, be dried to absolutely dry after feeling like jelly again.[nature and flavor with return through] are pungent, bitter, tepor.Return kidney, urinary bladder channel.[function with cure mainly] expelling wind and removing dampness, numbness relieving and pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache wind and cold holds wet headache under the arm.

Semen Impatientis: this product is the dry mature seed of Balsaminaceae plant Flos Impatientis ImpatiensbalsaminaL..Summer, autumn gather when fruit is about to ripe, dry, removing peel and impurity.[nature and flavor with return through] micro-hardship, pungent, temperature; Slightly poisonous.Return lung, Liver Channel.[function with cure mainly] removing blood stasis softening the hard mass, removing food stagnancy.For note of the ancient Chinese abdominal mass mass in the abdomen, amenorrhea, dysphagic.

Fructus Gardeniae grandiflorae: this product is the dry mature fruit of Maguireothamnus speciosus Flos Caryophylli Fructus Gardeniae GardeniajasminoidesEllisvar.grandillora (Lour.) Nakai.Collecting fruit about October, cuts off the calyx head deposited place, dries or dry after drying or boiling.[nature and flavor] are bitter, cold.[function with cure mainly] subsides a swelling active.For controlling injury from falling down bruise, skin bruise pain.

Flos Caryophylli: this product is the dry flower of plant clove of myrtaceae EugeniacaryophyllataThunb..Pluck when alabastrum turns red by green, dry.[nature and flavor with return through] are pungent, temperature.Return spleen, stomach, lung, kidney channel.[function with cure mainly] warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.

Rhizoma Cyperi: this product is the dry rhizome of sedge dried tuber CyperusrotundusL..Autumn excavates, sing the hair must, put in boiling water after slightly boiling or steaming and dry, or burn and directly to dry afterwards.[nature and flavor with return through] pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.[function with cure mainly] dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea.

Kadsura root: this product is the dry root of Magnoliacea plant Kadsura coccinea (Lem.) A. C. Smith Kadsuracoccinea (Lem.) A.C.Smith.Record in " Chinese Pharmacopoeia " version in 1977.Or Caulis Piperis Kadsurae, the i.e. dry rattan of Kadsura heteroclita Kadsuraheteroclita (Roxb.) Craib, record in " Guangxi Chinese crude drug standard ".[nature and flavor] are sweet, micro-pungent, temperature.[function with cure mainly] expelling wind and cold, promoting the circulation of QI to relieve pain, relaxing muscles and tendons and activating QI and blood in the collateral.For rheumatic arthritis, lumbar muscle strain, flu, puerperal paralysis.

Herba Centipedae: this product is the dry herb of feverfew Herba Centipedae Centipedaminima (L.) A.Br.etAschers..Summer, autumn two gather when season, the flowers are in blossom, wash away silt, dry.[nature and flavor with return through] are pungent, temperature.Return lung meridian.[function with cure mainly] dispersing wind-cold, clearing the nasal passage, cough-relieving.For headche due to wind-cold, cough with copious phlegm, has a stuffy nose obstructed, nasal sinusitis watery nasal discharge.

The Radix Linderae: this product is the dried root of canella Radix Linderae Linderaaggregata (Sims) Kosterm..The whole year all can excavate, and removing radicula, cleans, take advantage of fresh slices, dry, or directly dry.[nature and flavor with return through] are pungent, temperature.Return lung, spleen, kidney, urinary bladder channel.[function with cure mainly] promoting the circulation of QI to relieve pain, warming kidney for dispelling cold.For QI stagnated by cold, chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia pain, through cold stomachache.

Lobelia sessilifolia: this product is the dry root stock of Begoniaceae plant thick beak Flos Begoniae Evansianae BegoniacrassirostrisIrmsch., Begonia pedatifida BegoniapalmataD.Don or Pharmacognostical Study BegoniapedatifidaLevl..The whole year can adopt, and takes root stock, removing fibrous root, cleaning, drying.

Radix Aconiti Preparata: this product is this product is sheet that is irregular or Yangtze River Delta shape.Surface pitchy or yellowish-brown, have taupe brown cambium layer ring grain.Body is light, and matter is crisp, and section is glossy.Feeble QI, micro-have numb feeling in the tongue.[nature and flavor with return through] are pungent, bitter, heat; Poisonous.GUIXIN, liver,kidney,spleen warp.[function with cure mainly] expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain and narcotic analgesic.

Camphora: this product is 1,7,7 ?trimethyl bicyclo-[2.2.1] Geng Wan ?2 ?ketone, be in canella, extract (natural camphor) or with chemical synthesis obtained (artificial camphor).[function with cure mainly] orifice opening; Qi stagnation removing; Ward off foul; Killing parasites for relieving itching; Reducing swelling and alleviating pain.Main calentura coma; Attacked by pestiferous factors is dampinged off, and acute filthy disease is vomited and diarrhoea and suffered from abdominal pain; The disturbance of lower legs due to pathogenic cold and dampness; Scabies stubborn dermatitis; Tinea alba; Chilblain; Ecthyma; Burn due to hot liquid or fire; Traumatic pain; Toothache; Wind-fire acute conjunctivitis.

Another aspect of the present invention there is provided the preparation method of Chinese medicine composition active component in the present invention, the method active component of all the other raw material of Chinese medicine except Camphora is ethanol extractions of employing 40-80% concentration expressed in percentage by volume, and Camphora is ground into fine powder and adds and be prepared from.Concrete preparation method is as follows:

Get all the other raw material of Chinese medicine except Camphora, with 40-80% alcohol reflux 2-3 time, each ethanol consumption be the 4-10 of medical material total amount doubly, extraction time is 1-3 hour, merge extractive liquid, and filter, filtrate is condensed into fluid extract, and Camphora is ground into fine powder and adds, and to obtain final product.

Chinese medicine composition for enhancing immunity of the present invention, with pharmaceutically acceptable carrier combination, can make various common dosage forms, as tablet, granule, capsule, chewable tablet, pill etc.

Pharmaceutically acceptable carrier of the present invention includes but not limited to following:

Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.

Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.

Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.

Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.

Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.

Correctives: sucrose, monosaccharide, aromatic etc.

Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.

Fang Xie: we's card consumes impairment of QI Tianjin by daily life impermanence, and cause coagulation of QI-blood, healthy energy is not held up, and in exopathogen is dry, battalion defends inconsiderate again, yang deficiency susceptible.Control suitable blood circulation promoting and blood stasis dispelling, warming YANG and invigorating QI.Reuse Radix et Rhizoma Smilacis Ripariae in side, the Radix Linderae is monarch, Radix et Rhizoma Smilacis Ripariae sweet in the mouth, can put down filling blood, and can invigorate blood circulation again and soothing the channels and quicking the network vessels, especially we should control card; Radix Linderae Xin Kaiwen falls apart, kind dredging mechanism of qi, the male temperature of its gas, enters kidney channel and kind warming kidney for dispelling cold, can nourish body yang-energy with consolidating superficial resistance, enters spleen channel and QI invigorating warming the spleen alleviating distention in middle-JIAO, can help precise and tinyization life and rectify.Radix seu Caulis Parabarii can strengthen waist knee joint, bone and muscle strengthening, is the product of kidney invigorating and YANG supporting, can helps the gesture of Radix Linderae YANG invigorating; GUIHUAFU energy heat-clearing and toxic substances removing, helps Radix Linderae righting gas, the effect of blood-activating analgetic of holding concurrently again; Leaf of Radix Glycosmidis Citrifoliae enters Liver Channel and blood stasis dispersing and deswelling, and kind tune reaches blood vessels, vigorous blood; The effect of Herba Inulae cappae tool promoting the circulation of QI to relieve pain, again can tonify deficiency, and two arrogate to oneself its merit; Herba Artemisiae Anomalae function removing blood stasis stimulates the menstrual flow, eliminating stasis to stop pain, all cards of kind treatment blood stasis; Caulis Bauhihiae Championii merit is apt to blood circulation promoting competent silt, again can wind-damp dispelling, can the heresy of anti-rheumatism seize the opportunity body battalion defend inconsiderate and in invade; The effect of Radix Cudraniae tool blood circulation promoting and blood stasis dispelling, the merit of circulation of qi promoting of holding concurrently again; Radix Zanthoxyli acrid in the mouth is warm in nature, kind dispelling wind and removing obstruction in the collateral, reducing swelling and alleviating pain; Caulis Spatholobi merit is kind enriches blood, again can promoting the circulation of blood blood stasis dispelling, can the gesture of walk help monarch drug; Rhizoma Cyperi enters Liver Channel edema caused by disorder of QI, and its acrid in the mouth can fall apart, and bitter can receive, sweet energy and, especially kind regulating functional activities of qi, make the handsome blood of gas, blood vessels must be supported, and seek Wei get Gu, can invade in the heresy of anti-rheumatism, the effect of also double pain relieving.Below be all ministerial drug, principal drug assistance plays blood circulation promoting and blood stasis dispelling, the merit of warming YANG and invigorating QI.Fang Zhongzuo is with all medicines of Caulis et Folium hedyotis hedyotideae, Radix Achyranthis Bidentatae, Radix Angelicae Pubescentis, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Ramulus et Folium Claoxyli, Radix Solani indici, Semen Impatientis, Fructus Gardeniae grandiflorae, kadsura root, lobelia sessilifolia, Radix Aconiti Preparata, Herba Centipedae, Flos Caryophylli and Camphora.Caulis et Folium hedyotis hedyotideae merit benefaction blood and dissolving stasis, has again the effect of wind-damp dispelling, the effect of hemostasis held concurrently again, can all medicine promoting the circulation of blood of anti-we too and from through hemorrhage; Radix Piperis sarmentosi (Herba Piperis Sarmentosi) energy warming middle-JIAO to promote flow of QI, detumescence of dispeling the wind; Ramulus et Folium Claoxyli energy dissipating blood stasis, expelling wind and removing dampness; Radix Solani indici energy promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain; Semen Impatientis is apt to removing blood stasis softening the hard mass; Kadsura root acrid in the mouth, warm in nature, benefaction meridian qi and blood and replenishing vital QI with drugs of warm nature passages through which vital energy circulates; Fructus Gardeniae grandiflorae can be subsided a swelling active, has again a merit of heat clearing away; Lobelia sessilifolia is apt to heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Radix Aconiti Preparata function expelling wind and removing dampness, antalgic; Caulis et Folium Hyptidis suaveolentis is pungent cool, and gas is fragrant, dissipating blood stasis of both can having subsided a swelling, and tool induces sweat the effect of heat clearing away again, and its property is up; Radix Angelicae Pubescentis energy expelling wind and removing dampness, numbness relieving and pain relieving, induces sweat, and its property is also descending; Radix Achyranthis Bidentatae merit is apt to eliminating blood stasis and inducing menstruation, kind descending kidney yang of supplementing nutrition of igniting, and its property is also descending; Caulis et Folium Hyptidis suaveolentis, Radix Angelicae Pubescentis and Radix Achyranthis Bidentatae are the guiding drug of we.Herba Centipedae, Flos Caryophylli and Camphora fragrant odour, be apt to take all medicine medicine gesture and walk to alter meridians.All medicines are even for ball with Mel above, Mel coordinating the actions of various ingredients in a prescription, for we make medicine.The all medicines of we share, and blood circulation promoting and blood stasis dispelling is to deposit the eliminating evil gas of healthy energy, and warming YANG and invigorating QI is to defend the flesh natural fibre line of meat, and real battalion defends, therefore can drive exopathogen.The effect of small wooden raft drum is had in assertive evidence.

A kind of Chinese medicine composition for enhancing immunity provided by the invention has the following advantages:

1, in prescription of the present invention, each medicine share, and jointly plays blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, the effect of the merit of relaxing muscles and tendons and activating QI and blood in the collateral, can play the effect for the treatment of body fatigue preferably.

2, in mice delayed allergy experiment, compared with model group, give the mice after the present invention, swelling degree of the paw significantly increases, and delayed allergy (DTH) ability significantly strengthens, and effect is better than prior art; Cause in immunosuppressant experiment at dexamethasone, compared with model group, give the mice after the present invention, IL-2, TNF-α and IFN-γ level significantly raises, and immunocompetence significantly strengthens, and effect is better than prior art.

3, present composition formula is rationally innovated, and production cost is low, technique is simple.

Detailed description of the invention

The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Concentration of alcohol is percent by volume.

Embodiment 1

Take Caulis et Folium hedyotis hedyotideae 76g, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 76g, Radix et Rhizoma Smilacis Ripariae 76g, Radix Achyranthis Bidentatae 76g, Radix seu Caulis Parabarii 76g, GUIHUAFU 76g, leaf of Radix Glycosmidis Citrifoliae 76g, Herba Inulae cappae 76g, Herba Artemisiae Anomalae 76g, Caulis Bauhihiae Championii 76g, Caulis et Folium Hyptidis suaveolentis 76g, Radix Cudraniae 76g, Radix Zanthoxyli 76g, Caulis Spatholobi 76g, Ramulus et Folium Claoxyli 76g, Radix Solani indici 76g, Radix Angelicae Pubescentis 76g, Semen Impatientis 76g, Fructus Gardeniae grandiflorae 76g, Flos Caryophylli 38g, Rhizoma Cyperi 153g, kadsura root 153g, Herba Centipedae 76g, Radix Linderae 76g, lobelia sessilifolia 76g, Radix Aconiti Preparata 38g, Camphora 3g;

Get all the other raw material of Chinese medicine except Camphora, with 40% alcohol reflux 3 times, ethanol consumption is 6 times of medical material total amount, and extraction time is 1.5 hours, merge extractive liquid, filter, filtrate is condensed into fluid extract, is dried to dried cream powder, pulverizes, Camphora is ground into fine powder and adds, then add adjuvant xylitol, mannitol, magnesium stearate make chewable tablet.

Embodiment 2

Take Caulis et Folium hedyotis hedyotideae 70g, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 70g, Radix et Rhizoma Smilacis Ripariae 70g, Radix Achyranthis Bidentatae 70g, Radix seu Caulis Parabarii 70g, GUIHUAFU 70g, leaf of Radix Glycosmidis Citrifoliae 70g, Herba Inulae cappae 70g, Herba Artemisiae Anomalae 70g, Caulis Bauhihiae Championii 70g, Caulis et Folium Hyptidis suaveolentis 70g, Radix Cudraniae 70g, Radix Zanthoxyli 70g, Caulis Spatholobi 70g, Ramulus et Folium Claoxyli 70g, Radix Solani indici 70g, Radix Angelicae Pubescentis 70g, Semen Impatientis 70g, Fructus Gardeniae grandiflorae 70g, Flos Caryophylli 35g, Rhizoma Cyperi 135g, kadsura root 135g, Herba Centipedae 70g, Radix Linderae 70g, lobelia sessilifolia 70g, Radix Aconiti Preparata 35g, Camphora 2g;

Get all the other raw material of Chinese medicine except Camphora, with 60% alcohol reflux 2 times, ethanol consumption is 8 times of medical material total amount, and extraction time is 2 hours, merge extractive liquid, filter, filtrate is condensed into fluid extract, is dried to dried cream powder, pulverize, Camphora is ground into fine powder and adds, and adds supplementary product starch, cane sugar powder, Pulvis Talci, magnesium stearate, obtained granule.

Embodiment 3

Take Caulis et Folium hedyotis hedyotideae 70g, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 82g, Radix et Rhizoma Smilacis Ripariae 82g, Radix Achyranthis Bidentatae 82g, Radix seu Caulis Parabarii 82g, GUIHUAFU 82g, leaf of Radix Glycosmidis Citrifoliae 82g, Herba Inulae cappae 82g, Herba Artemisiae Anomalae 82g, Caulis Bauhihiae Championii 82g, Caulis et Folium Hyptidis suaveolentis 82g, Radix Cudraniae 82g, Radix Zanthoxyli 82g, Caulis Spatholobi 82g, Ramulus et Folium Claoxyli 82g, Radix Solani indici 82g, Radix Angelicae Pubescentis 82g, Semen Impatientis 82g, Fructus Gardeniae grandiflorae 82g, Flos Caryophylli 42g, Rhizoma Cyperi 170g, kadsura root 170g, Herba Centipedae 82g, Radix Linderae 82g, lobelia sessilifolia 82g, Radix Aconiti Preparata 42g, Camphora 5g;

Get all the other raw material of Chinese medicine except Camphora, with 80% alcohol reflux 2 times, ethanol consumption is 10 times of medical material total amount, and extraction time is 3 hours, merge extractive liquid, filter, filtrate is condensed into fluid extract, is dried to dried cream powder, pulverizes, Camphora is ground into fine powder and adds, then add microcrystalline cellulose excipients, hydroxypropyl cellulose, carboxymethyl starch sodium, Pulvis Talci, magnesium stearate make tablet.

Pharmacodynamics test:

1 material

1.1 medicine

Embodiment of the present invention 1-3, breviscapus pulse-engendering capsule, lot number 20141225, Yunnan Biological Valley Breviscapin Pharmaceutical Co., Ltd..Levamisole hydrochloride tablets, lot number 150103, south China, Guangdong Pharmaceutical Group Plc.Dexamethasone acetate tablets, lot number 140923, Tianjin Pharmaceutical Group Xinzheng Co., Ltd..

1.2 animal

SPF level Kunming mouse, is provided by Guangxi Medical University's medical experiment animal center, animal productiong licence SCXK osmanthus 2003-0003.

1.3 reagent and instrument

Mice (IL-2) Elisa test kit, lot number 141125, bio tech ltd is built up in Nanjing.Mice (TNF-α) Elisa test kit, lot number 141205, bio tech ltd is built up in Nanjing.Mice (IFN-γ) Elisa detection kit, lot number 141229, bio tech ltd is built up in Nanjing.Microplate reader, model MultiskanMK3, Thermo.

2 methods

2.1 delayed allergies (DTH, the sufficient sole of the foot thickens method)

Get SPF level KM kind mice, male, 18-22g, is divided into Normal group at random, embodiment group and positive control SHENGMAI JIAONANG group, often organizes 10.Animal presses 20mL/kg gastric infusion, Normal group gavage equal-volume normal saline, continuous 15d, every day 1 time, last administration first 4 days mouse peritoneal injection 2% (v/v) SRBC0.2ml/ sensitization, measures left back sufficient sole of the foot portion thickness after last administration, and at measurement section subcutaneous injection 20% (v/v) SRBC20 μ l/ only, after injection, 24h measures left back sufficient sole of the foot portion thickness, and same position measures 3 times, averages.To attack the degree that the sufficient sole of the foot thickness difference in front and back represents DTH.

2.2 couples of immunosuppressed mice IL-2, the impact of TNF-α and TFN-γ

Get male mouse of kunming 60, be divided into 6 groups at random, often organize 10, be respectively blank group, model group, levamisole group, embodiment 1-3 group.The each group of continuous gavage 30d of mice, gavage volume is 0.1ml/10g, and blank group and model group substitute with distilled water.Simultaneously except blank group, all the other each groups all gavaged 1.5mg/kg dexamethasone and carry out immunosuppressant modeling 1 time every 2 days, totally 15 times, after last gavage 6h, mice is plucked eyeball and gets blood, the centrifugal 10min separation of serum of 4000rpm, measures the content of IL-2, TNF-α and IFN-γ by test kit description.

2.3 statistical method

All experimental datas all with represent.Continuous data adopts SPSS13.0 statistical software to carry out checking between variance analysis and group.P<0.05 has statistical significance.

3 results, in table 1, table 2

Table 1 respectively organizes medicine to the effect of mice delayed allergy

The content of mice serum IL-2, TNF-α and IFN-γ respectively organized by table 2

Note: compare with blank group, * P < 0.05, * * P < 0.01; Compare with model control group, ☆ P < 0.05, ☆ ☆ P < 0.01; Compare with levamisole group, △ P < 0.05, △ △ P < 0.01;

From table 1, positive controls and each embodiment group mice delayed allergy (DTH) ability compare with blank group and significantly improve (P < 0.05), and embodiment 2 and embodiment 3 groups significantly improve (P < 0.05) than mice delayed allergy ability with positive controls.

Table 2 data show, compare with blank group, IL-2 in model group mice serum, TNF-α and IFN-γ content obviously reduce (P < 0.01), levamisole group and each embodiment group IL-2 is compared with model group, TNF-α and IFN-γ content obviously raise, and significant difference (P < 0.05), compare with levamisole group, embodiment 2 groups of TNF-α obviously raise (P < 0.05), embodiment 3 groups of IL-2, TNF-α and IFN-γ content obviously increase (P < 0.05).

4 discuss

The cytokines such as IL-2, TNF-α and IFN-γ participate in body inflammatory reaction, suppress the breeding of virus, antitumor, closely related with immune status.This research shows, the embodiment of the present invention can significantly improve mice delayed allergy ability, dexamethasone is caused to the level of IL-2, TNF-α and IFN-γ in immunosuppressed mice serum, shows that the embodiment of the present invention has the effect improving immunity, Be very effective, and be better than prior art.

Conclusion: the embodiment of the present invention has the effect improving immunity, Be very effective, and is better than prior art.

Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims

1. the Chinese medicine composition for enhancing immunity, it is characterized in that it is prepared from by the raw material of Chinese medicine of following weight portion: Caulis et Folium hedyotis hedyotideae 70-82 part, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 70-82 part, Radix et Rhizoma Smilacis Ripariae 70-82 part, Radix Achyranthis Bidentatae 70-82 part, Radix seu Caulis Parabarii 70-82 part, GUIHUAFU 70-82 part, leaf of Radix Glycosmidis Citrifoliae 70-82 part, Herba Inulae cappae 70-82 part, Herba Artemisiae Anomalae 70-82 part, Caulis Bauhihiae Championii 70-82 part, Caulis et Folium Hyptidis suaveolentis 70-82 part, Radix Cudraniae 70-82 part, Radix Zanthoxyli 70-82 part, Caulis Spatholobi 70-82 part, Ramulus et Folium Claoxyli 70-82 part, Radix Solani indici 70-82 part, Radix Angelicae Pubescentis 70-82 part, Semen Impatientis 70-82 part, Fructus Gardeniae grandiflorae 70-82 part, Flos Caryophylli 35-42 part, Rhizoma Cyperi 135-170 part, kadsura root 135-170 part, Herba Centipedae 70-82 part, Radix Linderae 70-82 part, lobelia sessilifolia 70-82 part, Radix Aconiti Preparata 35-42 part, Camphora 2-5 part.

2. as claimed in claim 1 for the Chinese medicine composition of enhancing immunity, it is characterized in that it is prepared from by the raw material of Chinese medicine of following weight portion: Caulis et Folium hedyotis hedyotideae 76 parts, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 76 parts, Radix et Rhizoma Smilacis Ripariae 76 parts, Radix Achyranthis Bidentatae 76 parts, Radix seu Caulis Parabarii 76 parts, GUIHUAFU 76 parts, leaf of Radix Glycosmidis Citrifoliae 76 parts, Herba Inulae cappae 76 parts, Herba Artemisiae Anomalae 76 parts, Caulis Bauhihiae Championii 76 parts, Caulis et Folium Hyptidis suaveolentis 76 parts, Radix Cudraniae 76 parts, Radix Zanthoxyli 76 parts, Caulis Spatholobi 76 parts, Ramulus et Folium Claoxyli 76 parts, Radix Solani indici 76 parts, Radix Angelicae Pubescentis 76 parts, Semen Impatientis 76 parts, Fructus Gardeniae grandiflorae 76 parts, Flos Caryophylli 38 parts, Rhizoma Cyperi 153 parts, kadsura root 153 parts, Herba Centipedae 76 parts, the Radix Linderae 76 parts, lobelia sessilifolia 76 parts, Radix Aconiti Preparata 38 parts, Camphora 3 parts.

3. as claimed in claim 1 or 2 for the Chinese medicine composition of enhancing immunity, it is characterized in that the active component of all the other raw material of Chinese medicine is ethanol extractions of employing 40-80% concentration expressed in percentage by volume except Camphora, Camphora is ground into fine powder and adds and be prepared from.

4. as claimed in claim 3 for the Chinese medicine composition of enhancing immunity, it is characterized in that the active component of all the other raw material of Chinese medicine is prepared from by the following method except Camphora: get all the other raw material of Chinese medicine except Camphora, with 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, and extraction time is 1-3 hour, merge extractive liquid, filter, filtrate is condensed into fluid extract, and Camphora is ground into fine powder and adds, and to obtain final product.

5. a Chinese medicine preparation for enhancing immunity, is prepared by acceptable carrier in the Chinese medicine composition for enhancing immunity described in claim 1 or 2 and pharmaceuticals industry and forms.