CN103169887B - Chinese patent medicine for improving sleep and preparation method of Chinese patent medicine - Google Patents
Chinese patent medicine for improving sleep and preparation method of Chinese patent medicine Download PDFInfo
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Abstract
The invention discloses a Chinese patent medicine for improving sleep and a preparation method of the Chinese patent medicine. The Chinese patent medicine for improving sleep comprises the following components in parts by weight: 3-20 parts of polygala tenuifolia, 6-20 parts of atractylodes macrocephala, 3-20 parts of bamboo shavings, 3-20 parts of licorice and 10-30 parts of prepared rehmannia root; and in addition, the Chinese patent medicine can also contains at least one component selected from 3-10 parts of radix bupleuri, 10-50 parts of cortex albiziae, 3-10 parts of radix sophorae flavescentis and 5-15 parts of salvia miltiorrhiza. The preparation method comprises the following steps of: firstly, weighing various crude drugs, and adding water for soaking the crude drugs; then carrying out ultrasonic extraction, and then, filtering to obtain filtrate; concentrating the filtrate and spray-drying to obtain active ingredients of the Chinese patent medicine for improving sleep; and finally, preparing the active ingredients into granules, tablets, capsules or oral liquid by using a conventional method. The medicine for improving sleep, disclosed by the invention, is proved by animal tests and clinical tests to have a favorable treatment effect for insomnia and have the total effective rate of over 93% in clinical treatment.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine, belong to technical field of Chinese medicines, particularly relate to Chinese patent medicine of a kind of improving water flood and preparation method thereof.
Background technology
Sleep is the necessary process of life, and being that body restores, integrates and the important step of consolidating memory, is healthy indispensable important component part.Along with the continuous propelling of modernization, social competition is day by day fierce, and the work of people and rhythm of life are accelerated, and remains difficult and constantly rises for the sickness rate of the insomnia of feature, more and more become a kind of commonly encountered diseases, the frequently-occurring disease of modern society to fall asleep and sleep.Chronic insomnia can bring huge infringement to the physical and mental health of people.Do not have enough sleep and body immunity not only can be made to decline, the ability of rehabilitation disease also can be made to reduce, bring out the outbreak of original disease.
Clinically, everyly can to fall asleep, extend the medicine of total sleep time or deep sleep's process by rapid induction, all contribute to Cure for insomnia.At present, the medicine for insomnia's treatment mainly contains chemicals, Chinese medicine and melatonin etc.Chemicals is the critical treatment means of insomnia, its effect is affirmed widely, but chemicals is while treatment of insomnia patients, its safety problem also highlights gradually: 1. drug resistance, most anti-insomnia chemicals uses after more than 2 weeks continuously, can lose efficacy gradually, and sound sleep and rapid-eye-movement sleep minimizing can be made even to disappear; 2. dependency and withdrawal symptom, after the anti-insomnia chemicals medication several months, physiological and psychological dependence all likely occur, and can cause anxiety, have a headache, tremble and insomnia increases the weight of (rebound insomnia) etc.; 3. untoward reaction, uses chemical anti-insomnia medicine such as triazolam, tavor and clonazepam etc. can affect cognition and memory function.
Melatonin is in recent years for the conventional raw material in the Ricipe for health care food of improving water flood.According to the preliminary statistics, at present to have more than 50% to be all take melatonin as the product of main formula composition in " improving water flood " health food that is health care.In recent years, increasing scientific research shows, melatonin improving water flood effect is still not clear, and long-term or high dose takes melatonin may produce harm, as obviously suppressed human reproductive system's function to human body.
The traditional Chinese medical science just has the record about insomnia from ancient times.Tradition is thought, Chinese medicine has the action character of Mutiple Targets, and the insomnia for cause of disease complexity has unique treatment advantage, and its source is natural, and side effect is little, has caused the extensive concern of modern scientific research and clinical practice.Go through the abundant of long term medical practice and development, in motherland's medical treasure-house, have accumulated a large amount of outstanding prescriptions, for the control of insomnia contributes, as Decoction of Gentiana for Purging the Liver-fire treatment liver-fire disturbs cardioid insomnia, decoction for removing blood stasis treatment type of blood-stasis obstructing in the interior insomnia etc.Through modern scientific research, the treatment of insomnia patients Chinese patent medicine having developed listing also has a variety of, as dredged strongly fragrant ANSHEN JIAONANG, Tianwang Buxin Dan and Bezoar Sedative Pills etc.
At present, the Chinese prescription patent literature aspect for insomnia also has much.Such as: 1, application number is 02144939.2, name is called the patent of invention of " a kind of medicine-sleeping pill of Cure for insomnia and preparation thereof ".2, application number is 200410104434.2, name is called the patent of invention of " a kind of medicine of improving water flood ".3, application number is 200710089551.X, name is called the patent of invention of " Chinese medicine composition of a kind of improving water flood and preparation method thereof ".4, application number is 200510009913.0, name is called the patent of invention of " a kind of medicine for the treatment of nervous prostration and improving sleep ".
Insomnia falls ill crowd extensively, and harm is serious.Therefore, there is the huge market space in anti-insomnia medicine, and exploitation improving water flood medicine has important economic implications and social meaning.Up to now, due to individual variation between different crowd, the Cure for insomnia Chinese medicine preparation curative effect developed is also uneven, and people are always constantly finding the better simultaneously safer Chinese medicine formula of therapeutic effect.
Summary of the invention
The technical problem to be solved in the present invention is: on the basis of using for reference traditional prescription, through pharmacological screening widely, provides Chinese patent medicine of a kind of improving water flood and preparation method thereof.The Chinese patent medicine of the improving water flood utilizing technical solution of the present invention to prepare, through animal experiment and clinical trial checking, have good therapeutic effect, and side effect is very little to insomnia.
In order to solve the problem, the technical solution used in the present invention is:
The invention provides a kind of Chinese patent medicine of improving water flood, represent with weight portion, described Chinese patent medicine contains Radix Polygalae 3 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 6 ~ 20 parts, Caulis Bambusae In Taenia 3 ~ 20 parts, 3 ~ 20 parts, Radix Glycyrrhizae and Radix Rehmanniae Preparata 10 ~ 30 parts.
According to the Chinese patent medicine of above-mentioned improving water flood, described Chinese patent medicine contains Radix Polygalae 3 ~ 8 parts, the Rhizoma Atractylodis Macrocephalae 6 ~ 10 parts, Caulis Bambusae In Taenia 3 ~ 10 parts, 3 ~ 8 parts, Radix Glycyrrhizae and Radix Rehmanniae Preparata 10 ~ 15 parts.
According to the Chinese patent medicine of above-mentioned improving water flood, described Chinese patent medicine contains Radix Polygalae 8 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Caulis Bambusae In Taenia 10 ~ 15 parts, 8 ~ 15 parts, Radix Glycyrrhizae and Radix Rehmanniae Preparata 15 ~ 30 parts.
According to the Chinese patent medicine of above-mentioned improving water flood, described Chinese patent medicine contains Radix Polygalae 15 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 15 ~ 20 parts, Caulis Bambusae In Taenia 10 ~ 20 parts, 15 ~ 20 parts, Radix Glycyrrhizae and Radix Rehmanniae Preparata 25 ~ 30 parts.
According to the Chinese patent medicine of above-mentioned improving water flood, described Chinese patent medicine also contains Radix Bupleuri 3 ~ 10 parts, Cortex Albiziae 10 ~ 50 parts, Radix Sophorae Flavescentis 3 ~ 10 parts and at least one in Radix Salviae Miltiorrhizae 5 ~ 15 parts.
According to the Chinese patent medicine of above-mentioned improving water flood, described Chinese patent medicine also contains Radix Bupleuri 5 ~ 10 parts, Cortex Albiziae 10 ~ 25 parts, Radix Sophorae Flavescentis 3 ~ 10 parts and at least one in Radix Salviae Miltiorrhizae 5 ~ 10 parts.
According to the Chinese patent medicine of above-mentioned improving water flood, described Chinese patent medicine also contains Radix Bupleuri 3 ~ 10 parts, Cortex Albiziae 25 ~ 40 parts, Radix Sophorae Flavescentis 3 ~ 10 parts and at least one in Radix Salviae Miltiorrhizae 8 ~ 12 parts.
According to the Chinese patent medicine of above-mentioned improving water flood, described Chinese patent medicine also contains Radix Bupleuri 3 ~ 10 parts, Cortex Albiziae 40 ~ 50 parts, Radix Sophorae Flavescentis 3 ~ 10 parts and at least one in Radix Salviae Miltiorrhizae 10 ~ 15 parts.
A kind of preparation method of Chinese patent medicine of improving water flood, described preparation method is: take various crude drug according to the proportioning of above-mentioned improving water flood Chinese patent medicine, then various crude drug is mixed, and add the water of 5 ~ 10 times amount, ultrasonic extraction is carried out after adding water, Extracting temperature is 60 ~ 80 DEG C, power is 250 ~ 800W, extract 2 ~ 3 times, each extraction time is 60 ~ 90min, filter after extraction, gained filtrate is concentrated into the thick paste that relative density is 1.15 ~ 1.21, carry out spraying dry, after dry, the moisture content of material is 3 ~ 5%, improve after drying sleep Chinese patent medicine active component, finally conventionally active component is made granule, tablet, capsule or oral liquid.
A preparation method for the Chinese patent medicine of improving water flood, described preparation method comprises the following steps:
A, take various crude drug according to the proportioning of above-mentioned improving water flood Chinese patent medicine, wherein by Radix Polygalae/or Radix Polygalae, Radix Sophorae Flavescentis and Cortex Albiziae/or Radix Polygalae and Radix Sophorae Flavescentis/or Radix Polygalae and Cortex Albiziae mixing, the concentration expressed in percentage by volume adding 6 ~ 10 times amount be 60 ~ 80% ethanol carry out reflux, extract, extract 2 ~ 3 times, each extraction 1 ~ 2 h, filter after extraction, gained filtrate is carried out decompression recycling ethanol, ethanol obtains Part I material after reclaiming;
B, then other is remained various crude drug mixing, add the water of 5 ~ 10 times amount, carry out ultrasonic extraction, Extracting temperature is 60 ~ 80 DEG C, and power is 250 ~ 800W, extracts 2 ~ 3 times, each extraction time is 60 ~ 90min, filter after extraction, gained filtrate is concentrated into the thick paste that relative density is 1.15 ~ 1.21, be i.e. Part II material;
C, two parts mixing of materials obtained by step a and b are even, then spraying dry is carried out, after dry, the moisture content of material is 3 ~ 5%, and the active component of the sleep Chinese patent medicine that improves after drying, finally conventionally makes tablet or capsule by active component.
the pharmacological action of the various crude drug of the present invention and chemical composition:
Radix Polygalae: GUIXIN, kidney, lung three warp.Effect: the effect such as Radix Polygalae has Fructus Alpiniae Oxyphyllae of calming the nerves, eliminates the phlegm, detumescence, is usually used in the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, the cards such as expectoration is not well, sore swollen toxin, breast swell and pain.This product can gas and mind tranquilizing and the heart calming happily, can lead to kidney qi and force not forget again, be restoring normal coordination between the heart and kidney, good merchantable brand that stable mind, Fructus Alpiniae Oxyphyllae are known by force.Bitter warm nature is dry, energy expelling phlegm for arresting cough, acrid in the mouth tonneau, and the sharp thinking of energy, by sputum.In Radix Polygalae, chemical composition is mainly polygalic acid, in addition also containing Radix Polygalae ketone, alkaloid, glucide, polygalytol, tenuidine, fatty oil and resin etc.
The Rhizoma Atractylodis Macrocephalae: return spleen, stomach warp.Effect: the Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, the effect such as antiabortive.Be usually used in insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, the cards such as frequent fetal movement.The Rhizoma Atractylodis Macrocephalae with spleen invigorating, dampness for Main Function, by forefathers praise for " air making-up and spleen enlivening first key medicine ", be both longer than QI invigorating with the strong fortune of multiple spleen, again can dampness, diuresis is with except damp.Containing volatile oil in the Rhizoma Atractylodis Macrocephalae, it mainly contains atractylone, atractylol, atractyloxide, juniper camphor, Rhizoma Atractylodis lactone etc., also containing fructose, inulin, Rhizoma Atractylodis polysaccharide in the Rhizoma Atractylodis Macrocephalae, and several amino acids and retinoid composition etc.
Caulis Bambusae In Taenia: return spleen, stomach warp.Effect: Caulis Bambusae In Taenia has removing heat-phlegm, the effect such as relieve restlessness and prevent vomiting, and be usually used in phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, the cards such as frequent fetal movement.The sweet cold profit of Caulis Bambusae In Taenia, kind Qinghua heat-phlegm, relieves restlessness and prevents vomiting.In Caulis Bambusae In Taenia, chemical composition mainly contains 2,5-dimethoxy-p-hydroxybenzaldehyde, syringic aldehyde, coniferyl aldehyde.
Radix Glycyrrhizae: GUIXIN, lung, spleen, stomach warp.Effect: Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the functions such as coordinating the actions of various ingredients in a prescription, are usually used in weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong, be one of medical material conventional in Chinese medicine formula.Main containing compositions such as triterpenes, flavonoid, alkaloid and polysaccharide in Radix Glycyrrhizae.
Radix Rehmanniae Preparata: return liver, kidney channel.Effect: Radix Rehmanniae Preparata has enriches blood moist, and beneficial essence fills out the effects such as marrow, is usually used in blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, collapses more than, hepatic and renal YIN deficiency, hectic fever night sweat, seminal emission sexual impotence, infertility, metrostaxis, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted, early whitening of beard and hair, quench one's thirst, constipation, the cards such as dyspnea with rapid and short breath of suffering from a deficiency of the kidney.The sweet Wen Zhirun of Radix Rehmanniae Preparata, nourishing YIN benefit essence is with hemopoietic, and be the key medicine of the tonify deficiency that nourishes blood, matter is moistened into kidney, and kind nourishing kidney yin, life essence-filling, marrow-benefitting is the key medicine of tonifying kidney-yin, and all kidney-YIN being deficient, marrow virtual loss person, all can use it.Main containing catalpol, rehmanin, mannitol, retinoid material, saccharide and aminoacid etc. in Radix Rehmanniae Preparata.
Radix Bupleuri: return liver, gallbladder meridian.Effect: Radix Bupleuri has depressed liver-energy dispersing and function of gallbladder promoting, dredges gas resolving depression, loose fire, the effects such as expelling pathogenic factors from the exterior expels the heat-evil, elevate a turnable ladder yang-energy, the cards such as cure mainly cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.The pungent loose hardship of Radix Bupleuri is let out, and is slightly cold and brings down a fever, and be good at eliminating evil inducing sweat and bring down a fever and evacuate the heresy of few positive half exterior and half interior, property is apt to bar and is reached irritability, dispersing the stagnated live-QI to relieve the stagnation of QI, again can the gas of the clear sun of elevate a turnable ladder taste, availablely controls deficiency of QI in middle-JIAO, and the feeling of heaviness in the epigastrium and abdomen caused by collapse of QI is done swollen, lack of appetite asthenia etc.Main containing saikoside, hitodesterol, oxeye alcohol and volatilization wet goods in Radix Bupleuri.
Cortex Albiziae: GUIXIN, liver, lung meridian.Effect: Cortex Albiziae has resolving depression of calming the nerves, and blood, mind calming, the effects such as subduing inflammation, commonly use and control irritability, melancholy, insomnia, lung abscess, carbuncle, scrofula, injured bone, the cards such as traumatic injury.Cortex Albiziae is kind separates stagnation of liver-QI, and be happy heart and tranquilizing mind key medicine, be suitable for feelings will unsuccessful, anger is melancholy, irritated insomnia, the diseases such as malaise, the five internal organs can be made to pacify and, will is happy, to receive the effect of resolving depression of calming the nerves.In Cortex Albiziae, main chemical compositions is saponin, flavone compound, in addition also containing tannin and multiple lignanoid and glucosides thereof.
Radix Sophorae Flavescentis: GUIXIN, liver, stomach, large intestine, urinary bladder channel.Effect: Radix Sophorae Flavescentis has heat clearing and damp drying, parasite killing, the effects such as diuresis, cure mainly hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.Radix Sophorae Flavescentis energy heat clearing and damp drying and control gastrointestinal damp and hot caused by have loose bowels, dysentery, again can killing parasites for relieving itching, diuresis.Containing alkaloids such as matrine, oxymatrine, Iosmatrine, sophocarpine, different sophocarpine, sophoramine, N-oxysophocarpine in Radix Sophorae Flavescentis, in addition containing flavone compounds such as picrol C, picrol G, isokurarinone, Radix Sophorae Flavescentis alcohol, neokurarinols.
Radix Salviae Miltiorrhizae: GUIXIN, Liver Channel.Effect: Radix Salviae Miltiorrhizae can stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, removing heat from blood eliminating carbuncle, and clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind, for menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia, hepatosplenomegaly, the cards such as angina pectoris.Blood circulation promoting and blood stasis dispelling is apt to by Radix Salviae Miltiorrhizae, cold nature and delaying, can promoting tissue regeneration by removing blood stasis and just do not hinder, the kind blood vessels that can pass through, and stasis-dispelling and pain-killing, is widely used in various blood stasis disease, can removing heat from blood and promoting blood circulation, again can heat clearing away eliminating carbuncle, and relieving restlessness is calmed the nerves, and energy nourishing blood and promoting blood circulation is with tranquilizing the mind.In Radix Salviae Miltiorrhizae, liposoluble constituent comprises tanshinone Ⅰ, Tanshinone II
a, Tanshinone II
b, TANSHINONES III, cryptotanshinone, hydroxyl TANSHINONES, Methyl tanshinoate, Przewaquinone A Przewatanshinquinone A, Przewatanshinquinone B Przewaquinone B., miltirone, tanshinol Ⅰ, tanshinol II, tanshinol III, salviol, Radix Salviae Miltiorrhizae aldehyde etc.Water soluble ingredient mainly contains danshensu, saivianic acid A, second, the third, protocatechuic acid, protocatechualdehyde etc.
The traditional Chinese medical science is thought, the kidney being the origin of congenital constitution, peace treating disorders in five ZANG-organs scheme in the ban in kidney.Cause the reason of insomnia numerous, treatment is first works as restoring normal coordination between the heart and kidney, and restriction is fire mutually, and make regulation between water and fire, dissipating depression of QI is freely cherished.In medicament composing prescription of the present invention, Radix Polygalae master enters heart kidney, can gas and mind tranquilizing and the heart calming happily, and can lead to again kidney qi and strong will is not forgotten, have the merit of peace internal organs, internal organs harmony is then had a sleepless night and mostly can be healed.Archaism speech " disorder of the stomach leading to insomnia with restlessness ", Caulis Bambusae In Taenia joins Radix Polygalae can easing stomach-QI, and both and then peacefully sleeping can the phase for the vital organs of the human body.The Rhizoma Atractylodis Macrocephalae coordinates Radix Rehmanniae Preparata to fill blood, nourishing kidney yin.Cortex Albiziae and Radix Polygalae, Radix Bupleuri compatibility, can dispersing the stagnated live-QI to relieve the stagnation of QI, plays the effect of tranquilizing by nourishing the heart.Radix Sophorae Flavescentis, Radix Bupleuri, Caulis Bambusae In Taenia coupling can clearly removing pathogen in the heart liver fire, Qinghua silt expectorant; Radix Salviae Miltiorrhizae can promoting blood circulation and cooling blood to calm the nerves.Radix Glycyrrhizae can the gas of heart-spleen boosting, is in harmonious proportion the property of each medical material in prescription.Take a broad view of this side, each medical material property of medicine is gentle, can reinforce insufficiency and reduce excessiveness, mind tranquilizing and the heart calming.
positive beneficial effect of the present invention:
The medicine of the improving water flood 1, utilizing technical solution of the present invention to prepare, through animal experiment and clinical trial checking, has good therapeutic effect to insomnia.
2, improving water flood Chinese patent medicine of the present invention proves through modern pharmacological research and clinical trial, and medicine of the present invention has clear and definite improving water flood effect, and totall effective rate in clinical treatment reaches more than 93%.
3, utilize technical solution of the present invention to prepare the technique of improving water flood pharmaceutical preparation simply, be convenient to quality control; In addition, adopt water supersound extraction mode, effective ingredient destroys few, and the pollution caused is very little, environmental friendliness, has significant social benefit.
4, utilize Drug therapy insomniac of the present invention, take safety, clinical practice few side effects.
utilize the clinical statistics data of the Drug therapy insomniac of improving water flood of the present invention:
In recent years, utilize general 200 many cases of the capsule for treating insomniac of the medicine of improving water flood of the present invention and improving water flood, concrete observation patient 100 example, wherein man 45 example, female 55 example, the age is 32
~between 76 years old, the mean age is 45 years old.
The instructions of taking of improving water flood capsule of the present invention: every capsules 350mg, oral, every day 2 times, one time 2
~4, serve on 15 days.
Efficacy assessment standard is:
Clinical recovery: recover the length of one's sleep normal, or Nighttime sleep is more than 6 hours, sleeps deep, energetic after waking up.
Effective: sleep is clearly better, and increases by more than 3 hours the length of one's sleep, Depth of sleep increases.
Effective: symptom alleviates, the length of one's sleep, comparatively front increase was less than 3 hours.
Invalid: not reach above-mentioned standard.
Therapeutic outcome: cure 15 examples, account for 15%; Effective 63 examples, account for 63%; Effective 15 examples, account for 15%; Invalid 7 examples, inefficiency 7%; Total effective rate reaches 93%.
model case:
1, Zhang, female, 46 years old, suffers from serious insomnia nearly 6 months.Symptom is: difficulty falling asleep, easily wakes up after sleeping, and has difficulty in going to sleep after waking up again, and mood is irritated, irritable, and be hard and dry, often sigh, the trick heart, health often generate heat.Through taking the improving water flood Chinese medicinal capsule that the embodiment of the present invention 12 is made, instructions of taking is: every day 1 time, each 3, every capsules 350mg, sleeps and takes for first 30 minutes.This patient takes improving water flood capsule of the present invention after two weeks continuously, and its sleep quality obviously improves, and all diseases alleviate, without other untoward reaction.After follow up a case by regular visits to and have no recurrence in 3 months.
2, Lee, female, 58 years old, suffers from 5 years insomnia histories, simultaneously with anxiety, depression, takes at ordinary times and stablely adds fluoxetine to maintain sleep.After change the improving water flood capsule taken the embodiment of the present invention 22 and make, simultaneously coordinate take melatonin.The instructions of taking of improving water flood capsule of the present invention is: every day 1 time, each 2, every 350mg, sleeps and takes for first 30 minutes; Melatonin instructions of taking is: every day 1 time, each 2, sleeps and takes for first 1 hour.After taking 15 days continuously, this patient sleeps obviously improves, and depression also has larger alleviation, has no adverse reaction.
3, Wang, man, 70 years old, suffers from nearly 2 years of insomnia, difficulty falling asleep at ordinary times, dreaming often and waking easily, has difficulty in going to sleep after waking up, vexed irritability after insomnia, often forgetful, nervous, abdominal part distension, abundant expectoration, be hard and dry.Take the improving water flood granule that the embodiment of the present invention 16 is made, instructions of taking is: every day 2 times, each 1 bag, every bag of 2.5g, respectively at p.prand 30 minutes and sleep and take for first 30 minutes.After taking 15 days continuously, this patient sleeps makes moderate progress, and continue to take 2 months, sleep quality has clear improvement, and each symptom alleviates to some extent, simultaneously day person, and memory significantly improves.
4, Zhao, man, 37 years old, suffers from insomnia 2 months, difficulty falling asleep, dreaming often and waking easily, after waking up, mood agitation has difficulty in going to sleep, and takes the improving water flood capsule that the embodiment of the present invention 6 is made, instructions of taking is: every day 1 time, each 2, every 350mg, sleeps evening and takes for first 30 minutes.After taking one week continuously, fall asleep simple, the number of times of waking up night reduces, and can again fall asleep very soon after waking up; Adhere to taking 1 week, sleep is basic recovers normal again.Follow up a case by regular visits to afterwards and have no recurrence in 3 months.
5, Zhang, female, 68 years old, suffers from nearly 5 months of insomnia, cardiopalmus, dreaming often and waking easily, lack of appetite, fear of cold.Take the improving water flood capsule that the embodiment of the present invention 6 is made, instructions of taking is: every day 2 times, each 2, every 350mg, namely sleeps take for first 30 minutes respectively at p.prand 30 minutes.After taking 15 days continuously, sleep quality significantly improves, and continues to take 1 month, and appetite increases, and other symptoms also alleviate to some extent.
6, Wu, female, 43 years old, suffers from nearly 6 months of insomnia, difficulty falling asleep, dreaming often and waking easily, thin white fur of tongue, fatigue and weakness.Take the improving water flood capsule that the embodiment of the present invention 6 is made, instructions of taking is: every day 1 time, each 3, every 350mg, sleeps and takes for first 30 minutes.After taking 15 days continuously, sleep is basic recovers normal, energetic, follows up a case by regular visits to and has no recurrence in 3 months.
7, grandson, man, 30 years old, suffer from nearly 2 years of insomnia, poor sleeping quality, dreaminess, in time, have dizzy, and hypomnesis, fatigue and asthenia, dry mouth with bitter taste, loose stool, red tongue, moist and slippery fur is greasy.Take the improving water flood capsule that the embodiment of the present invention 22 is made, instructions of taking is: every day 1 time, each 3, every 350mg, sleeps and takes for first 30 minutes.After taking 15 days continuously, sleep has larger improvement, and body is tired, dry mouth with bitter taste etc. is alleviated to some extent; Continue to take 3 months, memory is obviously improved, and follows up a case by regular visits to and has no recurrence in 3 months.
four, detailed description of the invention:
Set forth the present invention further below in conjunction with embodiment, but do not limit content of the present invention.
Embodiment 1:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 6g, Rhizoma Atractylodis Macrocephalae 10g, Caulis Bambusae In Taenia 8g, Radix Glycyrrhizae 3g and Radix Rehmanniae Preparata 10g.
Embodiment 2: substantially the same manner as Example 1, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 1, then various crude drug is mixed, and add the water accounting for raw material gross weight 10 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 400W, Extracting temperature is 80 DEG C, extract 2 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve after drying sleep Chinese patent medicine active component, finally conventionally add the mixing of appropriate silicon dioxide, capsule and improving water flood capsule of the present invention (every capsules 350mg) are made in filling.
Embodiment 3:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 3g, Rhizoma Atractylodis Macrocephalae 6g, Caulis Bambusae In Taenia 10g, Radix Glycyrrhizae 8g and Radix Rehmanniae Preparata 12g.
Embodiment 4: substantially the same manner as Example 3, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 3, then various crude drug is mixed, and add the water accounting for raw material gross weight 8 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 250W, Extracting temperature is 60 DEG C, extract 2 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve after drying sleep Chinese patent medicine active component, conventionally add appropriate lactose, Icing Sugar, mannitol and dextrin, pulverize and sieve mixing, with 95% ethanol for binding agent makes soft material, 20 mesh sieves are granulated, at 40 ~ 60 DEG C, oven drying is to moisture 2 ~ 4%, then 10 mesh sieve granulate are used, and add the magnesium stearate mixing of 1%, be pressed into tablet (every sheet 600mg).
Embodiment 5:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 8g, Rhizoma Atractylodis Macrocephalae 8g, Caulis Bambusae In Taenia 6g, Radix Glycyrrhizae 6g and Radix Rehmanniae Preparata 15g.
Embodiment 6: substantially the same manner as Example 5, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 5, then various crude drug is mixed, and add the water accounting for raw material gross weight 10 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 400W, Extracting temperature is 80 DEG C, extract 3 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve after drying sleep Chinese patent medicine active component, finally conventionally add the mixing of appropriate silicon dioxide, capsule and improving water flood capsule of the present invention (every capsules 350mg) are made in filling.
Embodiment 7:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 10g, Rhizoma Atractylodis Macrocephalae 15g, Caulis Bambusae In Taenia 10g, Radix Glycyrrhizae 10g and Radix Rehmanniae Preparata 15g.
Embodiment 8: substantially the same manner as Example 7, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 7, then various crude drug is mixed, and add the water accounting for raw material gross weight 5 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 800W, Extracting temperature is 80 DEG C, extract 3 times, each extraction time is 90min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve after drying sleep Chinese patent medicine active component, conventionally add appropriate lactose, Icing Sugar, mannitol and dextrin, pulverize and sieve mixing, with 95% ethanol for binding agent makes soft material, 20 mesh sieves are granulated, at 40 ~ 60 DEG C, oven drying is to moisture 2 ~ 4%, then 10 mesh sieve granulate are used, and add the magnesium stearate mixing of 1%, be pressed into tablet (every sheet 600mg).
Embodiment 9:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 15g, Rhizoma Atractylodis Macrocephalae 12g, Caulis Bambusae In Taenia 12g, Radix Glycyrrhizae 15g and Radix Rehmanniae Preparata 20g.
Embodiment 10: substantially the same manner as Example 9, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 9, then various crude drug is mixed, and add the water accounting for raw material gross weight 10 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 400W, Extracting temperature is 80 DEG C, extract 2 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve after drying sleep Chinese patent medicine active component, conventionally add appropriate lactose to pulverize, cross mix homogeneously after 100 mesh sieves, with 95% ethanol for binding agent makes soft material, 20 mesh sieves are granulated, at 40 ~ 60 DEG C, oven drying is to moisture 2 ~ 4%, then 10 mesh sieve granulate are used, subpackage makes granule (every bag of 2.5g).
Embodiment 11:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 8g, Rhizoma Atractylodis Macrocephalae 20g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 12g and Radix Rehmanniae Preparata 30g.
Embodiment 12: substantially the same manner as Example 11, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 11, then various crude drug is mixed, and add the water accounting for raw material gross weight 10 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 400W, Extracting temperature is 80 DEG C, extract 3 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, paste is carried out spraying dry, improve after drying sleep Chinese patent medicine active component, pulverized 100 mesh sieves, then add glycerol heating 60 ~ 80 DEG C of stirrings and make suspensoid, suppress with gelatin, cooling, make soft capsule.
Embodiment 13:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 15g, Rhizoma Atractylodis Macrocephalae 18g, Caulis Bambusae In Taenia 10g, Radix Glycyrrhizae 15g and Radix Rehmanniae Preparata 25g.
Embodiment 14: substantially the same manner as Example 13, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 13, then various crude drug is mixed, and add the water accounting for raw material gross weight 10 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 400W, Extracting temperature is 80 DEG C, extract 3 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, getting suitable amount of sucrose is dissolved in the water of 2 times amount, boil 10min, after making syrup with concentrated after extracting solution mix, stir, fill, oral liquid is made in sterilizing.
Embodiment 15:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 18g, Rhizoma Atractylodis Macrocephalae 20g, Caulis Bambusae In Taenia 20g, Radix Glycyrrhizae 18g and Radix Rehmanniae Preparata 30g.
Embodiment 16: substantially the same manner as Example 15, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 15, then various crude drug is mixed, and add the water accounting for raw material gross weight 10 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 750W, Extracting temperature is 80 DEG C, extract 2 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve after drying sleep Chinese patent medicine active component, conventionally add appropriate lactose to pulverize, cross mix homogeneously after 100 mesh sieves, with 95% ethanol for binding agent makes soft material, 20 mesh sieves are granulated, at 40 ~ 60 DEG C, oven drying is to moisture 2 ~ 4%, then 10 mesh sieve granulate are used, subpackage makes granule (every bag of 2.5g).
Embodiment 17:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 20g, Rhizoma Atractylodis Macrocephalae 15g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 20g and Radix Rehmanniae Preparata 28g.
Embodiment 18: substantially the same manner as Example 17, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 17, then various crude drug is mixed, and add the water accounting for raw material gross weight 10 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 400W, Extracting temperature is 80 DEG C, extract 2 times, each extraction time is 90min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve after drying sleep Chinese patent medicine active component, pulverized 100 mesh sieves, then add glycerol heating 60 ~ 80 DEG C of stirrings and make suspensoid, suppress with gelatin, cooling, make soft capsule.
Embodiment 19:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 8g, Rhizoma Atractylodis Macrocephalae 8g, Caulis Bambusae In Taenia 6g, Radix Glycyrrhizae 6g, Radix Rehmanniae Preparata 15g, Radix Bupleuri 6g, Cortex Albiziae 25g, Radix Sophorae Flavescentis 5g and Radix Salviae Miltiorrhizae 10g.
Embodiment 20: substantially the same manner as Example 19, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 19, then various crude drug is mixed, and add the water accounting for raw material gross weight 8 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 400W, Extracting temperature is 80 DEG C, extract 3 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve after drying sleep Chinese patent medicine active component, conventionally add appropriate lactose, Icing Sugar, mannitol and dextrin, pulverize and sieve mixing, with 95% ethanol for binding agent makes soft material, 20 mesh sieves are granulated, at 40 ~ 60 DEG C, oven drying is to moisture 2 ~ 4%, then 10 mesh sieve granulate are used, and add the magnesium stearate mixing of 1%, be pressed into tablet (every sheet 600mg).
Embodiment 21:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 8g, Rhizoma Atractylodis Macrocephalae 15g, Caulis Bambusae In Taenia 10g, Radix Glycyrrhizae 10g, Radix Rehmanniae Preparata 15g, Radix Bupleuri 6g, Cortex Albiziae 30g, Radix Sophorae Flavescentis 10g and Radix Salviae Miltiorrhizae 10g.
Embodiment 22: substantially the same manner as Example 21, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 21, then various crude drug is mixed, and add the water accounting for raw material gross weight 10 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 400W, Extracting temperature is 80 DEG C, extract 2 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve after drying sleep Chinese patent medicine active component, finally conventionally add the mixing of appropriate silicon dioxide, capsule and improving water flood capsule of the present invention (every capsules 350mg) are made in filling.
Embodiment 23:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 15g, Rhizoma Atractylodis Macrocephalae 12g, Caulis Bambusae In Taenia 12g, Radix Glycyrrhizae 15g, Radix Rehmanniae Preparata 20g, Cortex Albiziae 10g and Radix Salviae Miltiorrhizae 5g.
Embodiment 24: substantially the same manner as Example 23, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 23, then various crude drug is mixed, and add the water accounting for raw material gross weight 10 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 400W, Extracting temperature is 80 DEG C, extract 2 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve after drying sleep Chinese patent medicine active component, conventionally add appropriate lactose to pulverize, cross mix homogeneously after 100 mesh sieves, with 95% ethanol for binding agent makes soft material, 20 mesh sieves are granulated, at 40 ~ 60 DEG C, oven drying is to moisture 2 ~ 4%, then 10 mesh sieve granulate are used, subpackage makes granule (every bag of 2.5g).
Embodiment 25:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 10g, Rhizoma Atractylodis Macrocephalae 15g, Caulis Bambusae In Taenia 10g, Radix Glycyrrhizae 12g, Radix Rehmanniae Preparata 30g, Radix Bupleuri 10g and Cortex Albiziae 30g.
Embodiment 26: substantially the same manner as Example 25, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 25, then various crude drug is mixed, and add the water accounting for raw material gross weight 10 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 400W, Extracting temperature is 80 DEG C, extract 2 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve after drying sleep Chinese patent medicine active component, finally conventionally add the mixing of appropriate silicon dioxide, capsule and improving water flood capsule of the present invention (every capsules 350mg) are made in filling.
Embodiment 27:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 20g, Rhizoma Atractylodis Macrocephalae 15g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 20g, Radix Rehmanniae Preparata 28g and Radix Salviae Miltiorrhizae 15g.
Embodiment 28: substantially the same manner as Example 27, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is: first take various crude drug according to the proportioning of improving water flood Chinese patent medicine in embodiment 27, then various crude drug is mixed, and add the water accounting for raw material gross weight 10 times, 2h is soaked after adding water, ultrasonic extraction is carried out after immersion, ultrasonic power is 400W, Extracting temperature is 80 DEG C, extract 2 times, each extraction time is 60min, filter after extraction, merge extractive liquid, gained filtrate being concentrated into relative density is 1.15 ~ 1.21, carried out spraying dry, improve sleep Chinese patent medicine active component, conventionally add appropriate lactose, Icing Sugar, mannitol and dextrin, pulverize and sieve mixing, with 95% ethanol for binding agent makes soft material, 20 mesh sieves are granulated, at 40 ~ 60 DEG C, oven drying is to moisture 2 ~ 4%, then 10 mesh sieve granulate are used, and add the magnesium stearate mixing of 1%, be pressed into tablet (every sheet 600mg).
Embodiment 29:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 6g, Rhizoma Atractylodis Macrocephalae 10g, Caulis Bambusae In Taenia 6g, Radix Glycyrrhizae 3g and Radix Rehmanniae Preparata 10g.
Embodiment 30: substantially the same manner as Example 29, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is with embodiment 26.
Embodiment 31:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 6g, Rhizoma Atractylodis Macrocephalae 15g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 10g, Radix Rehmanniae Preparata 25g, Radix Bupleuri 10g and Radix Salviae Miltiorrhizae 6g.
Embodiment 32: substantially identical with embodiment 31, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is with embodiment 28.
Embodiment 33:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 6g, Rhizoma Atractylodis Macrocephalae 10g, Caulis Bambusae In Taenia 6g, Radix Glycyrrhizae 3g, Radix Rehmanniae Preparata 10g, Radix Bupleuri 6g, Cortex Albiziae 10g, Radix Sophorae Flavescentis 6g and Radix Salviae Miltiorrhizae 5g.
Embodiment 34: substantially identical with embodiment 33, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is with embodiment 26.
Embodiment 35: substantially identical with embodiment 33, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is:
A, first take Radix Polygalae, Radix Sophorae Flavescentis and Cortex Albiziae according to the proportioning of improving water flood Chinese patent medicine in embodiment 33, by its three kinds of crude drug mixing, then adding the concentration expressed in percentage by volume accounting for three kinds of raw material gross weights 8 times is that 70% ethanol carries out reflux, extract, extract 2 times altogether, each extraction 2 h, 2 times are extracted the filtrate after filtering merging, the filtrate after merging carries out decompression recycling ethanol, and ethanol obtains Part I material after reclaiming;
B, then other is remained various crude drug mixing, and add the water accounting for raw material gross weight 10 times, soak 2h after adding water, after immersion, carry out ultrasonic extraction, ultrasonic power is 800W, Extracting temperature is 80 DEG C, and extract 3 times, each extraction time is 90min, filter after extraction, merge extractive liquid, it is 1.15 ~ 1.21 that gained filtrate is concentrated into relative density, obtains Part II material;
C, two parts mixing of materials obtained by step a and b are even, then spraying dry is carried out, improve after drying the active component of sleep Chinese patent medicine, conventionally adds appropriate lactose, Icing Sugar, mannitol and dextrin, pulverize and sieve mixing, with 95% ethanol for binding agent makes soft material, 20 mesh sieves are granulated, and at 40 ~ 60 DEG C, oven drying is to moisture 2 ~ 4%, then uses 10 mesh sieve granulate, and add the magnesium stearate mixing of 1%, be pressed into tablet (every sheet 600mg).
Embodiment 36:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 6g, Rhizoma Atractylodis Macrocephalae 15g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 10g, Radix Rehmanniae Preparata 25g, Radix Bupleuri 10g and Cortex Albiziae 25g.
Embodiment 37: substantially identical with embodiment 36, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is with embodiment 28.
Embodiment 38:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 15g, Rhizoma Atractylodis Macrocephalae 20g, Caulis Bambusae In Taenia 10g, Radix Glycyrrhizae 10g, Radix Rehmanniae Preparata 15g, Cortex Albiziae 15g, Radix Sophorae Flavescentis 6g and Radix Salviae Miltiorrhizae 10g.
Embodiment 39: substantially identical with embodiment 38, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is with embodiment 24.
Embodiment 40:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 20g, Rhizoma Atractylodis Macrocephalae 10g, Caulis Bambusae In Taenia 20g, Radix Glycyrrhizae 6g, Radix Rehmanniae Preparata 30g and Radix Sophorae Flavescentis 6g.
Embodiment 41: substantially identical with embodiment 40, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is with embodiment 18.
Embodiment 42:
The Chinese patent medicine of improving water flood of the present invention, represents with weight portion g, and its raw material consists of Radix Polygalae 20g, Rhizoma Atractylodis Macrocephalae 10g, Caulis Bambusae In Taenia 20g, Radix Glycyrrhizae 6g, Radix Rehmanniae Preparata 30g, Radix Bupleuri 3g, Cortex Albiziae 45g, Radix Sophorae Flavescentis 6g and Radix Salviae Miltiorrhizae 10g.
Embodiment 43: substantially identical with embodiment 42, difference is:
The preparation method of the Chinese patent medicine of improving water flood of the present invention is with embodiment 14.
the Pharmacodynamic test of active extract of improving water flood Chinese patent medicine of the present invention:
In order to prove the therapeutic effect of Chinese patent medicine of the present invention to insomnia, the capsule adopting the embodiment of the present invention 34 to prepare, has carried out the following test of pesticide effectiveness.
1, test material:
1.1 reagent: pentobarbital sodium, purchased from Xi Tang bio tech ltd, Shanghai (purity >99%, German import subpackage); Diazepam, Three Jins, Shanxi pharmaceutcal corporation, Ltd; Chinese medicine preparation of the present invention (hereinafter referred to as " sleeping capsule "), 0.35 g/ grain.
1.2 experimental animals: SPF level Kunming mouse 50, female, body weight 18 ~ 22 g, is provided by Henan Province's Experimental Animal Center.The animal quality certification number: SCXK(Henan) 2010-002.Before experiment, mice conforms one week.
2, method and result:
2.1 impacts on mice autonomic activities:
Mice 50, be divided into 5 groups at random, often organize 10, gavage gives dosage (2.33 g/kg), sleeping capsule low dosage (1.16 g/kg), positive control drug (4mg/kg) in tap water, sleeping capsule high dose (4.66 g/kg), sleeping capsule respectively, continuous gavage 15 days.Within 13rd day, the test of mice autonomic activities is carried out at gastric infusion.Method of testing is: 30 min after administration, by mice by only putting into wilderness case (25 cm × 20, cm × 36 cm, bottom divides 20 lattice), after adapting to 2 min, mice autonomic activities number of times (lattice number), number of times of standing, reason hair number of times and defecation grain number in rear 3 min of record.Through t inspection, the results are shown in Table 1.
The autonomic activities situation of animal can reflect the functional status of its central nervous system.Grid number of walking in the case of wilderness represents the irritability of mice, and number of times of standing represents the adaptive capacity of mice to foreign environment, and reason hair number of times reflection mice is to the height of environment Vigilance, and defecation grain number reflects the tensity of mice.As can be seen from the test data of table 1, sleeping capsule middle and high dosage group and stable group of activity number of times remarkable reduction compared with blank group, low dose group is there was no significant difference compared with blank group; High dose group and stable group of mice are stood number of times remarkable reduction compared with blank group; Each administration group mice reason hair number of times and defecation frequency there was no significant difference compared with blank group.Result shows, high, the middle dosage of sleeping capsule can significantly suppress mice autonomic activities.
2.2 direct sleep laboratory:
Gastric infusion the 14th day, observes each test medicine and whether has direct sleep effect.Sleep is index with righting reflex loss, and record each group of sleep number of animals, it the results are shown in Table 2.If can produce sleep effect immediately after drug administration, then medication danger can increase.Direct sleep laboratory result shows, each group sleep mice number is 0, shows that medicine all acts on without direct sleep.
2.3 extend the pentobarbital sodium test length of one's sleep:
Before administration in 15th day, water 14 h is can't help in fasting, and administration 30 min pneumoretroperitoneum injection pentobarbital sodium (60 mg/kg), take righting reflex loss as index, observe and record mice righting reflex loss and recovery time.It is Sleep latency that mouse peritoneal is injected to sleeping duration, and righting reflex loss to recovery time is the length of one's sleep.Analyze through t inspection statistics, it the results are shown in Table 3.
As can be seen from Table 3, compared with blank group, sleeping capsule high dose group and stable group all significantly can reduce Sleep latency (p<0.05), and middle and high dosage group of sleeping and stable group mouse sleep time be significant prolongation (p<0.05) compared with blank group length of one's sleep.Result of the test shows, test medicine has good improving water flood effect.
Claims (7)
1. a Chinese patent medicine for improving water flood, is characterized in that, represents with weight portion, described Chinese patent medicine by crude drug Radix Polygalae 3 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 6 ~ 20 parts, Caulis Bambusae In Taenia 3 ~ 20 parts, 3 ~ 20 parts, Radix Glycyrrhizae, Radix Rehmanniae Preparata 10 ~ 30 parts, Radix Bupleuri 3 ~ 10 parts and Cortex Albiziae 10 ~ 50 parts composition.
2. the Chinese patent medicine of improving water flood according to claim 1, is characterized in that: described Chinese patent medicine by crude drug Radix Polygalae 3 ~ 8 parts, the Rhizoma Atractylodis Macrocephalae 6 ~ 10 parts, Caulis Bambusae In Taenia 3 ~ 10 parts, 3 ~ 8 parts, Radix Glycyrrhizae, Radix Rehmanniae Preparata 10 ~ 15 parts, Radix Bupleuri 5 ~ 10 parts and Cortex Albiziae 10 ~ 25 parts composition.
3. the Chinese patent medicine of improving water flood according to claim 1, is characterized in that: described Chinese patent medicine by crude drug Radix Polygalae 8 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Caulis Bambusae In Taenia 10 ~ 15 parts, 8 ~ 15 parts, Radix Glycyrrhizae, Radix Rehmanniae Preparata 15 ~ 30 parts, Radix Bupleuri 3 ~ 10 parts and Cortex Albiziae 25 ~ 40 parts composition.
4. the Chinese patent medicine of improving water flood according to claim 1, it is characterized in that: described Chinese patent medicine by crude drug Radix Polygalae 15 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 15 ~ 20 parts, Caulis Bambusae In Taenia 10 ~ 20 parts, 15 ~ 20 parts, Radix Glycyrrhizae and Radix Rehmanniae Preparata 25 ~ 30 parts, Radix Bupleuri 3 ~ 10 parts and Cortex Albiziae 40 ~ 50 parts composition.
5. the Chinese patent medicine of an improving water flood, it is characterized in that, represent with weight portion, described Chinese patent medicine by crude drug Radix Polygalae 3 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 6 ~ 20 parts, Caulis Bambusae In Taenia 3 ~ 20 parts, 3 ~ 20 parts, Radix Glycyrrhizae, Radix Rehmanniae Preparata 10 ~ 30 parts, Radix Bupleuri 3 ~ 10 parts, Cortex Albiziae 10 ~ 50 parts, Radix Sophorae Flavescentis 3 ~ 10 parts and Radix Salviae Miltiorrhizae 5 ~ 15 parts composition.
6. the preparation method of the Chinese patent medicine of an improving water flood, it is characterized in that, described preparation method for: take various crude drug according to the proportioning of the improving water flood Chinese patent medicine described in any one of Claims 1 to 5, then various crude drug is mixed, and add the water of 5 ~ 10 times amount, ultrasonic extraction is carried out after adding water, Extracting temperature is 60 ~ 80 DEG C, power is 250 ~ 800W, extract 2 ~ 3 times, each extraction time is 60 ~ 90min, filter after extraction, gained filtrate is concentrated into the thick paste that relative density is 1.15 ~ 1.21, carry out spraying dry, after dry, the moisture content of material is 3 ~ 5%, improve after drying sleep Chinese patent medicine active component, finally conventionally active component is made granule, tablet, capsule or oral liquid.
7. a preparation method for the Chinese patent medicine of improving water flood, is characterized in that, described preparation method comprises the following steps:
A, take various crude drug according to the proportioning of the improving water flood Chinese patent medicine described in any one of Claims 1 to 5, wherein by Radix Polygalae, Radix Sophorae Flavescentis and Cortex Albiziae/or Radix Polygalae and Cortex Albiziae mixing, the concentration expressed in percentage by volume adding 6 ~ 10 times amount be 60 ~ 80% ethanol carry out reflux, extract, extract 2 ~ 3 times, each extraction 1 ~ 2 h, filter after extraction, gained filtrate is carried out decompression recycling ethanol, ethanol obtains Part I material after reclaiming;
B, then other is remained various crude drug mixing, add the water of 5 ~ 10 times amount, carry out ultrasonic extraction, Extracting temperature is 60 ~ 80 DEG C, and power is 250 ~ 800W, extracts 2 ~ 3 times, each extraction time is 60 ~ 90min, filter after extraction, gained filtrate is concentrated into the thick paste that relative density is 1.15 ~ 1.21, be i.e. Part II material;
C, two parts mixing of materials obtained by step a and b are even, then spraying dry is carried out, after dry, the moisture content of material is 3 ~ 5%, and the active component of the sleep Chinese patent medicine that improves after drying, finally conventionally makes tablet or capsule by active component.
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| CN1083375A (en) * | 1993-05-07 | 1994-03-09 | 林树权 | Anshen san (sedative powder) |
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| CN1083375A (en) * | 1993-05-07 | 1994-03-09 | 林树权 | Anshen san (sedative powder) |
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| Title |
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| 失眠的中医药治疗概况;许继宗等;《中国中医药现代远程教育》;20110630;第9卷(第11期);166-167页 * |
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Effective date of registration: 20230620 Address after: No. 6 Shangding Road, Jinshui District, Zhengzhou City, Henan Province, 450000 Patentee after: Wang Shuncai Address before: No.58, Hongzhuan Road, Jinshui District, Zhengzhou City, Henan Province, 450000 Patentee before: HENAN BRANCH OF PLANT NATURAL PRODUCTS OF HIGH ENGINEERING TECHNOLOGY DEVELOPMENT CO.,LTD. |