A kind of Chinese medicine composition for the treatment of myocardial infarction Associated with Ventricular Aneurysm and preparation method thereof
Technical field
The invention discloses a kind of Chinese medicine composition, especially treat Chinese medicine composition of myocardial infarction Associated with Ventricular Aneurysm and preparation method thereof.Belong to Chinese medicine field.
Background technology
Myocardial infarction is to cause that by coronary atherosclerosis thrombosis, branch coronarius stop up, and makes a part of cardiac muscle lose blood supply and downright bad disease, multiple be born in the middle age after.When morbidity, have violent and lasting character, have the symptoms such as similar anginal front chest pain, cardiopalmus, asthma, weak and faint pulse, Blood pressure drop, take nitroglycerin invalid, consequence is serious.
After myocardial infarction there is locular wall expansion, attenuation, myocardium holostrome necrosis in infarcted region, downright bad cardiac muscle is substituted by fibrous scar tissue gradually; the outside bulging of ventricle wall of diseased region thin layer; LOM or present dyskinesis when heart contraction; formation myocardial infarction Associated with Ventricular Aneurysm, ventricular aneurysm is common in left ventricle.Ventricular aneurysm has a strong impact on cardiac function, not active treatment, and patient finally can be because of former cause deaths such as heart failure.
Ventricular aneurysm is divided into true property ventricular aneurysm and false ventricular aneurysm:
True property ventricular aneurysm is myocardium holostrome pathological changes and the ventricular aneurysm that forms; Sensu lato true property ventricular aneurysm can be divided into without motor type, move not three kinds of good figures and dyskinesis type on checking, wherein the pathological change of the ventricular aneurysm of dyskinesis type and narrow sense relatively meets.Necrotic myocardium and survival myocardium the result of depositing mostly without motor type or the good figure ventricular aneurysm not of moving.Locular wall attenuation is not obvious and lack the tumor sample of obvious fibrosis to expand region be usually its principal character.In survival myocardium, have plenty of with the form of hibernating myocardium and have the result of having plenty of ischemia and cause myocardial stunning, the ischemic cardiomyopathy of often saying clinically much also belongs to this class situation.
The true property ventricular aneurysm of narrow sense is one of complication of leaving over after flesh infarction, be characterized in the obvious attenuation of locular wall and form obvious Fibrotic tumor sample expanding region, it formed is usually after myocardial infarction, and process is usually divided into two pathology stages: early stage expansionary phase and moulding stage in late period.
False ventricular aneurysm refers to after left ventricle Slow fractures the tumor spline structure by pericardial tissue is wrapped to form around.
The modal symptom of ventricular aneurysm is angina pectoris, and ventricular aneurysm itself increases myocardial oxygen consumption, reduces oxygen supply, causes angina pectoris.Angina pectoris meeting increases the weight of dyspnea, may there is fatal arrhythmia in what have, conventionally the chance of occurrence of thromboembolism is less, but can cause the ischemia symptom of myocardial infarction and limbs or internal organs, therefore if find that in atrial fibrillation and ventricular aneurysm patient mural thrombus should draw attention.Secondly common symptom is dyspnea, and the heart failure, the arrhythmia that in the time that contractile function and diastolic function are all impaired, cause can cause cardiopalmus, faint, die suddenly.
Add rise and fall large, cold stimulation of emotion along with social high speed development operating pressure is large, overworked and all can make skin and subcutaneous tissue vasoconstriction, peripheral vascular resistance increases, very easily cause coronary vasospasm, thereby directly affect heart blood supply, bring out angina pectoris or myocardial infarction, the critical life of severe patient.
Now, for myocardial infarction Associated with Ventricular Aneurysm, patient can select doctor trained in Western medicine to carry out surgical operation therapy mostly.Although ventricular aneurysm can be directly excised in operation, ventricular aneurysm operating difficulty is large, have a big risk, mortality rate and complication rate high, patient and Team-Level thereof are required high, be global problem.The domestic minority doctor who only has several Heart centers few in number can carry out this operation at present, and technical merit and surgical effect are uneven, therefore brings very large hidden danger for the patient's who implements operative treatment safety.
Summary of the invention
For existing treatment present situation, one of object of the present invention is to provide a kind of Chinese medicine composition for the treatment of myocardial infarction Associated with Ventricular Aneurysm, by benefiting QI for activating blood circulation, removing obstruction in the collateral to relieve pain, hold up this to train first Chinese medicine composition, there is feature easy to operate, evident in efficacy, and it adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for myocardial infarction Associated with Ventricular Aneurysm, preferred proportioning, takes off the primary raw material of stating weight proportion and is prepared from: Radix Panacis Quinquefolii 1-5 part, Radix Astragali 20-35 part, Stigma Croci 1-5 part, Radix Salviae Miltiorrhizae 25-40 part, Radix Trichosanthis 25-35 part, Radix Curcumae 5-12 part, Concha Ostreae 9-30 part, Os Draconis 2-9 part, Radix Ophiopogonis 5-15 part, Fructus Hordei Germinatus 25-35 part, Flos Sophorae 5-9 part, Haematitum 9-30 part (preferred, Haematitum 9.5-29.5 part).
Treat a Chinese medicine composition for myocardial infarction Associated with Ventricular Aneurysm, preferred scheme, takes off the primary raw material of stating weight proportion and is prepared from: Radix Panacis Quinquefolii 2-4 part, Radix Astragali 25-30 part, Stigma Croci 2-4 part, Radix Salviae Miltiorrhizae 30-35 part, Radix Trichosanthis 28-32 part, Radix Curcumae 7-10 part, Concha Ostreae 15-25 part, Os Draconis 3-7 part, Radix Ophiopogonis 8-12 part, Fructus Hordei Germinatus 28-32 part, Flos Sophorae 6-8 part, Haematitum 15-25 part.
Treat a Chinese medicine composition for myocardial infarction Associated with Ventricular Aneurysm, best scheme, takes off the primary raw material of stating weight proportion and is prepared from: 3 parts of Radix Panacis Quinquefoliis, 28 parts of the Radixs Astragali, 3 parts of Stigma Crocis, 32 parts of Radix Salviae Miltiorrhizaes, 30 parts of Radix Trichosanthis, 8 parts of Radix Curcumaes, 20 parts of Concha Ostreaes, 6 parts of Os Draconis, 10 parts of Radix Ophiopogonis, 30 parts, Fructus Hordei Germinatus, 7 parts, Flos Sophorae, 20 parts of Haematitums.
A preparation method for the treatment of the Chinese medicine composition of myocardial infarction Associated with Ventricular Aneurysm, preparation process is as follows:
1. by Concha Ostreae, Os Draconis are cleaned, and pulverize for subsequent use;
2. Haematitum is removed to impurity, pound into the fritter as coin, be placed in non iron container, be blended into cold water 2000-5000 milliliter, intense fire is fried open, and turns 20-40 minute at a simmer;
3. by powder and the Radix Panacis Quinquefolii of milled in 1., the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Radix Curcumae, Radix Ophiopogonis, Fructus Hordei Germinatus, Flos Sophorae adds in the container that decocts Haematitum together, and intense fire is fried open, and turns 20-50 minute at a simmer, leaches medicinal liquid.
The preparation method of above-mentioned Chinese medicine composition, 2. step is blended into cold water 2000-5000 milliliter (preferably 3000-4500 milliliter, is more preferably 4000 milliliters).
The preparation method of above-mentioned Chinese medicine composition, 2. step turns 20-40 at a simmer minute (preferably 25-35 minute, is more preferably 30 minutes).
The preparation method of above-mentioned Chinese medicine composition, 3. step turns 20-50 at a simmer minute (preferably 25-45 minute, is more preferably 40 minutes).
Using method: for making the present invention reach best therapeutic effect, mixed decoction is divided into two parts, takes every day sooner or later after meal half an hour.
The pharmacological effect of each crude drug is respectively:
Radix Panacis Quinquefolii: sweet in the mouth, micro-hardship, cool in nature.GUIXIN, lung, kidney channel.There is boosting qi and nourishing yin, effect of clearing away heat and promoting production of body fluid, for improving immunity of organisms, anticancer growth, the deficiency of vital energy is cloudy loses.
The Radix Astragali: sweet in the mouth, warm in nature.Have effect of invigorating QI to consolidate the body surface resistance, diuretic detumescent, weak for the deficiency of vital energy, blood deficiency and yellow complexion, is Qi-tonifying drug.
Stigma Croci: sweet in the mouth, property is flat.There is the intracellular oxygen metabolism function of enhancing, improve the hypoxia-bearing capability of heart, blood circulation promoting and blood stasis dispelling, effect of removing pathogenic heat from blood and toxic substance from the body, has certain protective role to heart, and has the anticancer effect of cancer that significantly presses down.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.There is stasis-dispelling and pain-killing, nourishing blood to tranquillize the mind, effect of promoting blood circulation to restore menstrual flow, for breast ventral spine pain, dysphoria and insomnia, angina pectoris.
Radix Trichosanthis: sweet in the mouth, cold nature.Have promoting the circulation of QI the chest stuffiness relieving, effect of detumescence and apocenosis, has a pain for uncomfortable in chest, calentura excessive thirst.
Radix Curcumae: bitter in the mouth, pungent, cold in nature.There is promoting blood circulation and stopping pain, regulating qi to disperse stagnation, effect of the removing heat from blood that clears away heart-fire, for chest and abdomen swelling and pain, twinge.
Concha Ostreae: salty in the mouth, cold nature.There is tranquillization with heavy prescription, hard masses softening and resolving, effect of YANG hyperactivity suppressing nourishing YIN, for quietness insomnia, vertigo and tinnitus.
Os Draconis: sweet in the mouth, puckery, property is flat.Have another name called: Lu Hu loses life, that gal bone, Os Draconis, Os Draconis (calcined), five OS DRACONISs, green grass or young cropsization Os Draconis, OS DRACONIS, Os Draconis.For ancient times mammal as if the fossil of the skeleton of class, rhinoceros class, Hippocampal cortex etc.There is tranquillizing and allaying excitement, hemostasis, effect of promoting tissue regeneration and ulcer healing, demented for infantile convulsion, insomnia and dreamful sleep.
Radix Ophiopogonis: sweet in the mouth, property cold syndrome of the stomach.Have YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, On Antagonizing Experimental Arrhythmia, and effect of increase coronary flow, for vexed insomnia, Tianjin wound is thirsty.
Fructus Hordei Germinatus: sweet in the mouth, property is flat.There is spleen benefiting and stimulating the appetite, effect of QI invigorating, for playing abdominal distention and pain, food stagnation does not disappear.
Flos Sophorae: bitter in the mouth, cold nature.There is cooling blood for hemostasis, effect of purging liver-fire, for having blood in stool, dysentery, spits blood, the symptom such as headache is dizzy.
Haematitum: bitter in the mouth, cold in nature.There is suppressing the hyperactive liver and subsiding YANG, sending down the abnormal ascending QI, effect of hemostasis, for vertigo and tinnitus, vomiting, eructation.
1. benefiting QI for activating blood circulation: effect that Radix Panacis Quinquefolii in medicine, Stigma Croci, the Radix Astragali, Fructus Hordei Germinatus etc. have QI invigorating, invigorate blood circulation, can effectively improve the uncomfortable in chest and deficiency of vital energy that myocardial infarction Associated with Ventricular Aneurysm brings.
2. press down cancer anticancer: the Radix Panacis Quinquefolii in medicine, Stigma Croci have significant but the anticancer effect of cancer has good therapeutical effect to myocardial infarction Associated with Ventricular Aneurysm.
3. pain relieving: Radix Salviae Miltiorrhizae in medicine, Radix Trichosanthis, Radix Curcumae etc. have the effect of pain relieving analgesic, in Drug therapy disease, palliate the agonizing sufferings to patient.
4. vital base and primordial QI consolidating, improves immunity: Radix Panacis Quinquefolii, the Radix Astragali etc. in medicine have vital base and primordial QI consolidating, improves the effect of autoimmunity, in treatment, improves physical function.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1
1 gram of Radix Panacis Quinquefolii, 20 grams of the Radixs Astragali, 1 gram of Stigma Croci, 25 grams of Radix Salviae Miltiorrhizaes, 25 grams of Radix Trichosanthis, 5 grams of Radix Curcumaes, 9 grams of Concha Ostreaes, 2 grams of Os Draconis, 5 grams of Radix Ophiopogonis, 25 grams, Fructus Hordei Germinatus, 5 grams, Flos Sophorae, 9 grams of Haematitums.
1. by Concha Ostreae, Os Draconis are cleaned, and pulverize for subsequent use;
2. Haematitum is removed to impurity, pound into the fritter as coin, be placed in non iron container, be blended into 2000 milliliters, cold water, intense fire is fried open, and turns 20 minutes at a simmer;
3. by powder and the Radix Panacis Quinquefolii of milled in 1., the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Radix Curcumae, Radix Ophiopogonis, Fructus Hordei Germinatus, Flos Sophorae adds in the container that decocts Haematitum together, and intense fire is fried open, and turns 20 minutes at a simmer, leaches medicinal liquid.
embodiment 2
2 grams of Radix Panacis Quinquefoliis, 25 grams of the Radixs Astragali, 2 grams of Stigma Crocis, 30 grams of Radix Salviae Miltiorrhizaes, 28 grams of Radix Trichosanthis, 7 grams of Radix Curcumaes, 15 grams of Concha Ostreaes, 3 grams of Os Draconis, 8 grams of Radix Ophiopogonis, 28 grams, Fructus Hordei Germinatus, 6 grams, Flos Sophorae, 15 grams of Haematitums.
1. by Concha Ostreae, Os Draconis are cleaned, and pulverize for subsequent use;
2. Haematitum is removed to impurity, pound into the fritter as coin, be placed in non iron container, be blended into 3000 milliliters, cold water, intense fire is fried open, and turns 25 minutes at a simmer;
3. by powder and the Radix Panacis Quinquefolii of milled in 1., the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Radix Curcumae, Radix Ophiopogonis, Fructus Hordei Germinatus, Flos Sophorae adds in the container that decocts Haematitum together, and intense fire is fried open, and turns 25 minutes at a simmer, leaches medicinal liquid.
embodiment 3
4 grams of Radix Panacis Quinquefoliis, 30 grams of the Radixs Astragali, 4 grams of Stigma Crocis, 35 grams of Radix Salviae Miltiorrhizaes, 32 grams of Radix Trichosanthis, 10 grams of Radix Curcumaes, 25 grams of Concha Ostreaes, 7 grams of Os Draconis, 12 grams of Radix Ophiopogonis, 32 grams, Fructus Hordei Germinatus, 8 grams, Flos Sophorae, 25 grams of Haematitums.
1. by Concha Ostreae, Os Draconis are cleaned, and pulverize for subsequent use;
2. Haematitum is removed to impurity, pound into the fritter as coin, be placed in non iron container, be blended into 4500 milliliters, cold water, intense fire is fried open, and turns 35 minutes at a simmer;
3. by powder and the Radix Panacis Quinquefolii of milled in 1., the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Radix Curcumae, Radix Ophiopogonis, Fructus Hordei Germinatus, Flos Sophorae adds in the container that decocts Haematitum together, and intense fire is fried open, and turns 45 minutes at a simmer, leaches medicinal liquid.
embodiment 4
5 grams of Radix Panacis Quinquefoliis, 35 grams of the Radixs Astragali, 5 grams of Stigma Crocis, 40 grams of Radix Salviae Miltiorrhizaes, 35 grams of Radix Trichosanthis, 12 grams of Radix Curcumaes, 30 grams of Concha Ostreaes, 9 grams of Os Draconis, 15 grams of Radix Ophiopogonis, 35 grams, Fructus Hordei Germinatus, 9 grams, Flos Sophorae, 30 grams of Haematitums.
1. by Concha Ostreae, Os Draconis are cleaned, and pulverize for subsequent use;
2. Haematitum is removed to impurity, pound into the fritter as coin, be placed in non iron container, be blended into 5000 milliliters, cold water, intense fire is fried open, and turns 40 minutes at a simmer;
3. by powder and the Radix Panacis Quinquefolii of milled in 1., the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Radix Curcumae, Radix Ophiopogonis, Fructus Hordei Germinatus, Flos Sophorae adds in the container that decocts Haematitum together, and intense fire is fried open, and turns 50 minutes at a simmer, leaches medicinal liquid.
embodiment 5
3 grams of Radix Panacis Quinquefoliis, 28 grams of the Radixs Astragali, 3 grams of Stigma Crocis, 32 grams of Radix Salviae Miltiorrhizaes, 30 grams of Radix Trichosanthis, 8 grams of Radix Curcumaes, 20 grams of Concha Ostreaes, 6 grams of Os Draconis, 10 grams of Radix Ophiopogonis, 30 grams, Fructus Hordei Germinatus, 7 grams, Flos Sophorae, 20 grams of Haematitums.
1. by Concha Ostreae, Os Draconis are cleaned, and pulverize for subsequent use;
2. Haematitum is removed to impurity, pound into the fritter as coin, be placed in non iron container, be blended into 4000 milliliters, cold water, intense fire is fried open, and turns 30 minutes at a simmer;
3. by powder and the Radix Panacis Quinquefolii of milled in 1., the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Radix Curcumae, Radix Ophiopogonis, Fructus Hordei Germinatus, Flos Sophorae adds in the container that decocts Haematitum together, and intense fire is fried open, and turns 40 minutes at a simmer, leaches medicinal liquid.
Using method: for making the present invention reach best therapeutic effect, mixed decoction is divided into two parts, takes every day sooner or later after meal half an hour.
model case one
Liu XX, man, 26 years old, Xuecheng District, Zaozhuang City of Shandong Province.Symptom: without inducement burst cardiopalmus, accompany the diseases such as uncomfortable in chest, dizzy, continue not alleviate for 1 hour, go hospital's Electrocardioscopy to show paroxysmal tachycardia, take nitroglycerin invalid, check by UCG, be diagnosed as old myocardial infarction, its operative treatment is advised by hospital.Sick age: 3 years.Examine the time: on May 15th, 2011; Use Chinese medicine composition of the present invention, take 2 days, cardiopalmus, dizzy transference cure; Take 1 month, do not occur again during this time tachycardic symptom; Take 3 months, Electrocardioscopy is normal, and UCG shows that myocardial infarction region disappears; Consolidate 1 month, recover, so far not recurrence.
model case two
Lee XX, female, 39 years old, Shenxian County, Liaocheng of Shandong Province.Symptom: back pain, after patient's fatigue, there is recurrent dizziness, accompany black Before-daybreak, show effect every day more than ten times, while squatting down, symptom is alleviated to some extent, without hypertension, diabetes, History of Coronary Heart Disease, find through hospital's ultrasound cardiogram inspection: left ventriculography shows that left chamber anterior basal segment, front side wall, the apex of the heart, diaphragmatic surface, posterior basal segment motion seriously weaken, and apex ventricular aneurysm forms.Sick age: 5 years.Examine the time: on August 20th, 2010; Use Chinese medicine composition of the present invention, take 1 week, back pain symptom alleviates, black Before-daybreak the number minimizing of dizzy companion, every day 5 left and right; Take after 2 months, dizzy transference cure, back pain is only outbreak once in a while; Continue to take 4 months, every malaise symptoms disappears, and goes examination in hospital ventricular aneurysm to disappear, and during taking, has no side effect.
model case three
Zou XX, man, 60 years old, Ling County, Dezhou City Shandong Province.Symptom: when sleeping at night, occur turning on eyes, two upper limb are twitched, and cry out it not react; family members are to its external chest compression about 5 minutes, and consciousness recovery has the symptom of chest distress usually, and can put down sleeping night; can be engaged in daily routines, be hypertrophic cardiomyopathy through hospital diagnosis, has slightly and block.Sick age: 1 month.Examine the time: on April 9th, 2011; Use Chinese medicine composition of the present invention, take chest distress transference cure 5 days; Take 1 month, do not occur again during this time the symptom of twitching night; Continue to take 1 month, find through examination in hospital, block phenomenon and disappear; Consolidate 1 week, recover.Drug withdrawal is not recurrence so far.
In order to verify the effect of Chinese medicine composition of the present invention, we have carried out on a large scale, the drug study (embodiment 5) of many person-times.Specific experiment result is as following table:
Table 1:
Prove through clinical trial, Chinese medicine composition effective percentage of the present invention is 95.8%, and compared to doctor trained in Western medicine surgical operation therapy, effective percentage is high by 12.5%, and cure rate is high by 27.5%, and the cure rate of Chinese medicine composition of the present invention is 94.2%.And treatment safety coefficient is far away higher than surgical operation therapy, and the safety coefficient for the treatment of reaches 99%, and the symptoms such as the angina pectoris being caused by myocardium Associated with Ventricular Aneurysm, out of breath and body circulation arterial thrombosis are had to obvious remissive treatment effect.In clinical observation, having no obvious adverse reaction, is a kind of comparatively ideal and medicine without any harm of myocardial infarction Associated with Ventricular Aneurysm for the treatment of.
The application's prescription is distinguished veteran doctors of TCM proved recipe, has the prospect of industrialized implementation.Completing of this invention has benefited from Shandong Province's 12 Planning emphasis subjects---the support of Law of Economy subject fund.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.