CN106421510A

CN106421510A - Medicine for treating atherosclerosis

Info

Publication number: CN106421510A
Application number: CN201611211556.0A
Authority: CN
Inventors: 吴福
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-12-25
Filing date: 2016-12-25
Publication date: 2017-02-22

Abstract

The invention relates to a medicine and particularly provides a medicine for treating atherosclerosis. The medicine is characterized by being prepared from the following Chinese herbal medicine raw materials in parts by weight: 9-30 parts of radix salviae miltiorrhizae, 6-20 parts of Chinese angelica, 3-12 parts of frankincense, 3-15 parts of myrrh, 15-60 parts of hawthorn roots, 9-15 parts of tea tree roots, 15-30 parts of corn stigmas, 15-30 parts of radix ilicis asprellae, 6-15 parts of radix puerariae, 3-12 parts of radix cynanchi paniculati and 9-30 parts of snakegourd peels. The medicine with the prescription can be used for effectively treating atherosclerosis through synergistic effects of activating blood to dredge vessels, regulating lipid and softening blood vessels, and diminishing inflammation and restoring pulses; and the medicine has an obvious clinical effect, is nontoxic and safe, and has a few of untoward effects.

Description

One kind treats atherosclerotic medicine

Technical field

The present invention relates to a kind of medicine is and in particular to one kind treats atherosclerotic medicine.

Background technology

The feature of atherosclerosiss (AS) be pathological changes from the beginning of endarterium, successively have lipid and compound saccharide accumulation, Go out thrombosiss, proliferation of fibrous tissue and calcinosises.And have medial gradually regression and calcification.Atherosclerosiss (AS) a kind of chronic inflammation processes being caused by multifactor, being characterized with the cellular elementss reaction of high degree of specificity, mainly Factor has dyslipidemia, hypertension, smoking, diabetes, obesity, age factor and inherited genetic factorss etc..Pathogenesis are blood Endothelial tube damages, lipid accumulation and fiber atherosclerosis plaque forming, atherosclerosiss (AS) mainly cause whole blood circulation or The pathological changes of indivedual organs, more common as coronary heart disease and cerebrovascular disease, data shows Drug therapy, and particularly Intensive Lipid-lowing is controlled After treatment, pathological changes can partial remission.And unsatisfactory using fat-reducing medicament merely at present, and need long-term taking.Sometimes two kinds are also needed Or two or more Drug combination, side effect is many, and untoward reaction is serious.Expansion of blood vessels medicine, adjusts hypolipidemic medicine, and anti-blood is little Treat numerous and diverse when plate medicine, thrombus dissolving and anticoagulant drug synthesis use, side effect and untoward reaction are many, the risk of operative treatment Greatly.So, the comprehensive medicine that exploration collection blood circulation and channel invigorating, tune fat soft pulse, antiinflammatory answer arteries and veins is significant.

The coronary heart disease that at present Chinese medicine causes because of atherosclerosiss (AS) and the medicine of cerebrovascular disease are more, but For atherosclerosiss (AS), and be Coronary intervention medicine less, and collection promoting blood circulation is logical on drug regimen Arteries and veins, adjusts fat soft pulse, and the active drug of the multiple arteries and veins comprehensive function of antiinflammatory is still few, is worth furtheing investigate further.

Content of the invention

For the deficiencies in the prior art, the invention provides one kind treats atherosclerotic medicine, logical by promoting blood circulation Arteries and veins, adjusts fat soft pulse, the synergism of the multiple arteries and veins of antiinflammatory, effectively treatment atherosclerosiss.

The technical scheme is that, one kind treats atherosclerotic medicine it is characterised in that by following weight portion The herbal raw material composition of number：Radix Salviae Miltiorrhizae 9-30 part, Radix Angelicae Sinensis 6-20 part, Olibanum 3-12 part, Myrrha 3-15 part, Radix Crataegi 15-60 part, Radix Camelliae sinensiss 9-15 part, Stigma Maydis 15-30 part, Radix Ilicis Asprellae 15-30 part, Radix Puerariae 6-15 part, Radix Cynanchi Paniculati 3-12 part, Pericarpium Trichosanthiss 9-30 Part.

As optimization, a kind of treat atherosclerotic medicine it is characterised in that Chinese herbal medicine by following parts by weight Raw material forms：9 parts of Radix Salviae Miltiorrhizae, 6 parts of Radix Angelicae Sinensis, 3 parts of Olibanum, 3 parts of Myrrha, 15 parts of Radix Crataegi, 9 parts of Radix Camelliae sinensiss, 15 parts of Stigma Maydis, 15 parts of Radix Ilicis Asprellae, 6 parts of Radix Puerariae, 3 parts of Radix Cynanchi Paniculati, 9 parts of Pericarpium Trichosanthiss.

As optimization, a kind of treat atherosclerotic medicine it is characterised in that Chinese herbal medicine by following parts by weight Raw material forms：30 parts of Radix Salviae Miltiorrhizae, 20 parts of Radix Angelicae Sinensis, 12 parts of Olibanum, 15 parts of Myrrha, 60 parts of Radix Crataegi, 15 parts of Radix Camelliae sinensiss, Stigma Maydis 30 Part, 30 parts of Radix Ilicis Asprellae, 15 parts of Radix Puerariae, 12 parts of Radix Cynanchi Paniculati, 30 parts of Pericarpium Trichosanthiss.

As optimization, a kind of treat atherosclerotic medicine it is characterised in that Chinese herbal medicine by following parts by weight Raw material forms：20 parts of Radix Salviae Miltiorrhizae, 12 parts of Radix Angelicae Sinensis, 9 parts of Olibanum, 12 parts of Myrrha, 45 parts of Radix Crataegi, 12 parts of Radix Camelliae sinensiss, Stigma Maydis 20 Part, 20 parts of Radix Ilicis Asprellae, 12 parts of Radix Puerariae, 9 parts of Radix Cynanchi Paniculati, 20 parts of Pericarpium Trichosanthiss.

The present invention can boil decoction and take, and be also subjected to the preparation method of conventional Chinese herbal and crude drugs preparationses, make granule, piece Agent, capsule etc., conveniently take and be easy to promote.

The invention has the advantages that：1st, by Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Olibanum, Myrrha, Radix Crataegi, Radix Camelliae sinensiss, Stigma Maydis, Radix Ilicis Asprellae, Pueraria lobota Root, Radix Cynanchi Paniculati, Pericarpium Trichosanthiss etc. ten herbal raw material composition simply, prescription medicine of the present invention is divided three classes by theory of Chinese medical science：With pellet Ginseng, Radix Angelicae Sinensis, Olibanum, Myrrha blood circulation and channel invigorating, adjust fat soft pulse with Radix Crataegi, Radix Camelliae sinensiss, Stigma Maydis, long with Radix Ilicis Asprellae, Radix Puerariae, Xu Minister in ancient times, the multiple arteries and veins of Pericarpium Trichosanthiss antiinflammatory.Blood circulation and channel invigorating class medicine is mainly expansion of blood vessels, improves tissue QC blood supply, removes tremulous pulse athero- Speckle, adjusts fat soft pulse class medicine mainly to adjust dyslipidemia, prevents lipid accumulation and fiber atherosclerosis plaque forming, the multiple arteries and veins of antiinflammatory Class medicine is mainly the chronic class disease reactivity pathological changes removing arterial wall, recovers normal morphology and the function of blood vessel.2nd, the present invention Prescription medicine is through clinical verification：By blood circulation and channel invigorating, adjust fat soft pulse, the synergism of the multiple arteries and veins of antiinflammatory, effectively treatment tremulous pulse medicated porridge Sample hardens, and clinical effectiveness is obvious, non-toxic and safe, and untoward reaction is few, and suitable relatively long-term therapy uses, and not only reduces the numerous and diverse of medication Property, and toxic and side effects and untoward reaction are few, suitable long-term taking, take in early days.3rd, the present invention is for early treatment's tremulous pulse medicated porridge Sample hardens, and prevents hypertension, coronary heart disease, the occurrence and development of cerebrovascular disease have main practice significance.

The Chinese herbal medicine mechanism of action of medicine of the present invention is as follows.

Radix Salviae Miltiorrhizae：Nature and flavor are bitter, are slightly cold；Return through：GUIXIN, Liver Channel；Indication：Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness that clears away heart-fire； For menoxenia, closed dysmenorrhea, lump in the abdomen, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, dysphoria and insomnia；Hepatosplenomegaly, Angina pectoriss.

Radix Angelicae Sinensis：Nature and flavor sweet, acrid, warm；Return through：Return liver, the heart, spleen channel；Indication：Replenishing and activating blood, menstruction regulating and pain relieving, intestine moistening is led to Just；For blood deficiency and yellow complexion, dizziness palpitaition, menoxenia, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, rheumatic arthralgia, fall and flutter damage Wound, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow, for closed dysmenorrhea, rheumatic arthralgia, injury from falling down.

Olibanum：Nature and flavor are pungent, bitter, tepor；Return through：The heart, liver, spleen channel；Indication：Blood-activating and qi-promoting, inducing menstruation to relieve menalgia, detumescence life Flesh；Main trusted subordinate's pain, rheumatic arthralgia, closed dysmenorrhea, traumatic injury stasis caused pain, swollen ulcer drug, acute appendicitis, the sore being festered and unhealed.

Myrrha：Nature and flavor are bitter, put down；Return through：Liver, spleen, the heart, kidney channel；Indication：Promoting blood circulation and stopping pain, detumescence and promoting granulation；The main chest and abdomen stasis of blood Bitterly, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle swells sore, acute appendicitis, conjunctival congestion and swelling pain.

Radix Crataegi：Nature and flavor are sweet, put down, nontoxic；Return through：Stomach, Liver Channel；Indication：Removing food stagnancy stomach function regulating, hemostasis, wind-dispelling, detumescence； Staple food amasss, dysentery, regurgitation, rheumatic arthralgia, spitting of blood, anal fistula, edema.

Radix Camelliae sinensiss：Nature and flavor are bitter, cool；Return through：The heart, kidney channel；Indication：Heart tonifying diuresis, promoting blood flow to regulate menstruation, heat-clearing and toxic substances removing；Main Heart disease, edema, hepatitis, dysmenorrhea, sore swollen toxin, aphtha, soup fire burn, herpes zoster, psoriasiss.

Stigma Maydis：Nature and flavor are sweet, light, put down；Return through：Return bladder, liver, gallbladder meridian；Indication：Inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting；With In acute and chronic nephritis, edema, anxious, chronic hepatitiss, hypertension, diabetes, chronic sinusitiss, lithangiuria, Biliary Calculi is little Just unfavorable, the disease such as neonatal jaundice caused by dampness-heat.

Radix Ilicis Asprellae：Nature and flavor are bitter, sweet, tremble with fear；Return through：Lung, liver, large intestine channel；Indication：Heat clearing away, promotes the production of body fluid, dissipating blood stasis, removing toxic substances；Main Flu, headache, dizziness, pyreticosis polydipsia, eruptive disease, diarrhea of heat type, lung abscess, pertussis, laryngopharynx swelling and pain, hemorrhoidal bleeding, gonorrhea, furuncle swelling toxin, falls Beat and damage.

Radix Puerariae：Nature and flavor are sweet, pungent, cool；Return through：Returns spleen, stomach；Indication：Expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, and yang invigorating stops Rush down；Have a headache for fever caused by exogenous pathogens, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels；Hypertension neck pain.

Radix Cynanchi Paniculati：Nature and flavor are pungent, temperature；Return through：Return liver, stomach；Indication：Wind-dispelling removing dampness, antalgesic-antipruritic；For rheumatism numbness Bitterly, stomachache distension, toothache, lumbago, injury from falling down, urticaria, eczema.

Pericarpium Trichosanthiss：Nature and flavor are sweet, slight bitter, tremble with fear；Return through：Enter lung, stomach；Indication：Removing heat from the lung and dissipating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens；Cure mainly Cough due to lung-heat, pharyngalgia, the thoracic obstruction, quench one's thirst, constipation.

Specific embodiment

With reference to embodiments the specific embodiment of the present invention is described in detail.

Embodiment 1：A kind of treat atherosclerotic medicine it is characterised in that the Chinese herbal medicine by following parts by weight is former Material composition：9 parts of Radix Salviae Miltiorrhizae, 6 parts of Radix Angelicae Sinensis, 3 parts of Olibanum, 3 parts of Myrrha, 15 parts of Radix Crataegi, 9 parts of Radix Camelliae sinensiss, 15 parts of Stigma Maydis, Radix Ilicis Asprellae 15 parts, 6 parts of Radix Puerariae, 3 parts of Radix Cynanchi Paniculati, 9 parts of Pericarpium Trichosanthiss.

Embodiment 2：A kind of treat atherosclerotic medicine it is characterised in that the Chinese herbal medicine by following parts by weight is former Material composition：30 parts of Radix Salviae Miltiorrhizae, 20 parts of Radix Angelicae Sinensis, 12 parts of Olibanum, 15 parts of Myrrha, 60 parts of Radix Crataegi, 15 parts of Radix Camelliae sinensiss, 30 parts of Stigma Maydis, 30 parts of Radix Ilicis Asprellae, 15 parts of Radix Puerariae, 12 parts of Radix Cynanchi Paniculati, 30 parts of Pericarpium Trichosanthiss.

Embodiment 3：A kind of treat atherosclerotic medicine it is characterised in that the Chinese herbal medicine by following parts by weight is former Material composition：20 parts of Radix Salviae Miltiorrhizae, 12 parts of Radix Angelicae Sinensis, 9 parts of Olibanum, 12 parts of Myrrha, 45 parts of Radix Crataegi, 12 parts of Radix Camelliae sinensiss, 20 parts of Stigma Maydis, hilllock 20 parts of Radix Mume, 12 parts of Radix Puerariae, 9 parts of Radix Cynanchi Paniculati, 20 parts of Pericarpium Trichosanthiss.

Decoction decocting and usage and dosage：By embodiment 3, the herbal decoction piece of the standby one day consumption of people of choosing, raw material is placed In clay pot or ceramic pot, add the decocting of seven times of total medical material amount to boil for the first time one and a half hours, take filtrate；Add total medicine for the second time The decocting that village measures five times boils a hour, takes filtrate, and third time adds the decocting that three times are measured in Zong Yao village to boil half an hour, takes filtrate. Three medicinal liquid mixing are concentrated and is 600 milliliters.Take daily three times, each serving 200 milliliters, 30 days is a course for the treatment of, can take 1-6 treatment Journey.

Diagnostic method：1st, there is dyslipidemia, the age is more than 40 years old.2nd, there are essential hypertension or type 2 diabetes mellitus.3、 Overweight for a long time or obesity；4th, clinical visible mental and flag, makes a definite diagnosis body surface artery such as carotid artery, radial artery, brachial artery Thicker etc. finding, elongated, tortuous and hardening；5th, the angiography of multi-slices CT or nuclear magnetic resonance (MRI) and ultrasonic Imaging can show AS；6th, intravascular ultrasonic imaging (IVUS) can directly observe SA pathological changes situation etc..As long as above 4 have wherein 2 Item is above and auxiliary examination can be diagnosed as AS for more than 1.

Outcome measure：A is effective：1st, dyslipidemia recovers normal.2nd, clinical symptom disappearance.3rd, complication is obviously improved. 4th, imaging examination pathological changes disappear or partial remission.B is effective：1st, dyslipidemia is obviously improved.2nd, clinical symptom disappearance.3rd, concurrent Disease is controlled.4th, imaging examination improvement is inconspicuous.C is invalid：No improve or deteriorate to begin a project and increase.

Clinical treatment is summarized：AS32 example treated altogether by applicable medicine of the present invention, wherein, male 25, women 7, the age is Little 38 years old, maximum 65 years old, the averagely ill age was 48 years old；There are dyslipidemia 20, hypertension 15, type 2 diabetes mellitus 5；Hat Shape AS15 example, brain AS17 example；There are the obvious pathological changes of organ 10；Asymptomatic stage or concealment phase 22.Average course for the treatment of is 4 months（120 My god）, result：Effective 20, effective 8, invalid 4, total effective rate is 87.5%.

Model case：1st, Liao, man, 45 years old, tells vexed swollen property pain after one week cause tired generation breastbone, companion sees left shoulder Discomfort, to examination in hospital, dyslipidemia：TCHO 7.2mmol/L,TG 2.8mmol/L,HDL-CH 0.4mmol/L,LDL-CH 4.5mmol/L, blood pressure 130/95 mmHg, multi-slice spiral CT angiography shows crown AS.Diagnosis：1st, dyslipidemia.2nd, crown AS.3rd, stable angina pectoris.Give the Drug therapy that the present invention treats AS, prescription：Radix Salviae Miltiorrhizae 20g, Radix Angelicae Sinensis 12g, Olibanum 9g Myrrha 12g, Radix Crataegi 45g, Radix Camelliae sinensiss 12g, Stigma Maydis 20g, Radix Ilicis Asprellae 20g, Radix Puerariae 12g, Radix Cynanchi Paniculati 9g, Pericarpium Trichosanthiss 20g.Daily One pair, take by decoction decocting method and usage and dosage.Three courses for the treatment of of medication（90 days）Clinical symptom disappearance, can do general muscle power Work, check blood fat is normal, and iconography is checked crown AS and is obviously improved, and treatment is effectively.

2nd, Zeng, male, 52 years old, tells dizziness three days, with seeing ataxia, disequilibrium, sometimes feels that double lower limb is unexpected Powerless it is not intended to know obstacle, no drop attack, no nausea and vomiting, seek medical advice to hospital, lab testing：TCHO 6.8mmol/L TG 3.0mmol/L, HDL-CH 0.38mmol/L, LDL-CH 4.6mmol/L.Head CT angiography shows：Vertebra substrate AS.Examine Disconnected：1st, dyslipidemia.2nd, brain AS.3rd, Transient ischemic attack.Give Drug therapy of the present invention：Prescription：Radix Salviae Miltiorrhizae 30g, Radix Angelicae Sinensis 20g, Olibanum 12g Myrrha 15g, Radix Crataegi 60g, Radix Camelliae sinensiss 15g, Stigma Maydis 30g, Radix Ilicis Asprellae 30g, Radix Puerariae 15g, Radix Cynanchi Paniculati 12g, Pericarpium Trichosanthiss 30g.Daily one pair, take by decoction decocting method and usage and dosage.Four courses for the treatment of of medication（120 days）Clinical condition Shape disappears, and check blood fat is normal, and iconography is checked crown AS and is obviously improved, and treatment is effectively.

3rd, Chen, man, 45 years old, patient had hypertension history 3 years, and systolic pressure fluctuates between 130-160mmhg, diastolic pressure Fluctuate between 90-105mmhg, non-Canonical management, feel within nearly three days dizzy weak, coordinate differential force, to examination in hospital prompting Brain AS diagnoses：1st, hypertension, 2, brain AS, 3, brain TIA.Give Drug therapy of the present invention, prescription：Radix Salviae Miltiorrhizae 20g, Radix Angelicae Sinensis 12g, Olibanum 9g Myrrha 12g, Radix Crataegi 45g, Radix Camelliae sinensiss 12g, Stigma Maydis 20g, Radix Ilicis Asprellae 20g, Radix Puerariae 12g, Radix Cynanchi Paniculati 9g, Fructus Trichosanthis Skin 20g.Daily one pair, by decoction decocting method and usage and dosage treatment, take medicine five months（150 days）After treatment, blood pressure is substantially steady Fixed, CT examination shows that brain AS improves, no clinical symptoms, belongs to treatment effectively.

Claims

1. a kind of treat atherosclerotic medicine it is characterised in that being made up of the herbal raw material of following parts by weight：Red Ginseng 9-30 part, Radix Angelicae Sinensis 6-20 part, Olibanum 3-12 part, Myrrha 3-15 part, Radix Crataegi 15-60 part, Radix Camelliae sinensiss 9-15 part, Stigma Maydis 15-30 part, Radix Ilicis Asprellae 15-30 part, Radix Puerariae 6-15 part, Radix Cynanchi Paniculati 3-12 part, Pericarpium Trichosanthiss 9-30 part.

2. treat atherosclerotic medicine according to claim 1 it is characterised in that medium-height grass by following parts by weight Medicine raw material forms：9 parts of Radix Salviae Miltiorrhizae, 6 parts of Radix Angelicae Sinensis, 3 parts of Olibanum, 3 parts of Myrrha, 15 parts of Radix Crataegi, 9 parts of Radix Camelliae sinensiss, 15 parts of Stigma Maydis, 15 parts of Radix Ilicis Asprellae, 6 parts of Radix Puerariae, 3 parts of Radix Cynanchi Paniculati, 9 parts of Pericarpium Trichosanthiss.

3. treat atherosclerotic medicine according to claim 1 it is characterised in that medium-height grass by following parts by weight Medicine raw material forms：30 parts of Radix Salviae Miltiorrhizae, 20 parts of Radix Angelicae Sinensis, 12 parts of Olibanum, 15 parts of Myrrha, 60 parts of Radix Crataegi, 15 parts of Radix Camelliae sinensiss, Stigma Maydis 30 parts, 30 parts of Radix Ilicis Asprellae, 15 parts of Radix Puerariae, 12 parts of Radix Cynanchi Paniculati, 30 parts of Pericarpium Trichosanthiss.

4. treat atherosclerotic medicine according to claim 1 it is characterised in that medium-height grass by following parts by weight Medicine raw material forms：25 parts of Radix Salviae Miltiorrhizae, 12 parts of Radix Angelicae Sinensis, 9 parts of Olibanum, 12 parts of Myrrha, 45 parts of Radix Crataegi, 12 parts of Radix Camelliae sinensiss, Stigma Maydis 20 Part, 20 parts of Radix Ilicis Asprellae, 12 parts of Radix Puerariae, 9 parts of Radix Cynanchi Paniculati, 20 parts of Pericarpium Trichosanthiss.