CN105687961A

CN105687961A - Preparation method of granule for treating coronary artery atherosclerosis

Info

Publication number: CN105687961A
Application number: CN201610164879.2A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-03-07
Filing date: 2014-03-07
Publication date: 2016-06-22
Also published as: CN103845670A; CN105687962A; CN103845670B

Abstract

The invention discloses a preparation method of a granule for treating coronary artery atherosclerosis. The granule is mainly prepared from the following raw material medicine in parts by weight: 6 to 9 parts of trichosanthes, 6 to 12 parts of ageratum conyzoides, 6 to 10 parts of cassia twig, 2 to 8 parts of sea backthern, 6 to 15 parts of bulbus allii macrostemonis, 3 to 6 parts of mulberry bark, 4 to 9 parts of radix salviae miltiorrhizae, 5 to 9 parts of dried mussel, 2 to 5 parts of radix stemonae, 6 to 15 parts of pinellia ternata, 6 to 12 parts of grifola, 4 to 10 parts of rhizoma alismatis and 3 to 9 parts of trogopterus dung. The preparation method also has good effects that the selected materials are all traditional Chinese medical materials without any toxic and side effects; the recipe conforms to the traditional Chinese medicine principle and body and metal characteristics of a patient with a coronary heart disease; on the promise of the general principle, different recipes can be used according to different people groups; the functions are different; the granule has the efficacies of activating blood to promote menstruation, and dissipating blood stasis to relive pain, and has the special curative effect on the treatment of the coronary artery atherosclerosis and the coronary heart disease.

Description

A kind of preparation method treating coronary atherosclerosis electuary

Divisional application, original applying number 2014100821592, applying date 2014.03.07, the electuary of title treatment coronary atherosclerosis and preparation method。

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to electuary of a kind for the treatment of coronary atherosclerosis and preparation method thereof。

Background technology

Atherosclerosis (Atherosclerosis) is type the most common and important in arteriosclerosis, and the inner membrance of the tremulous pulse that is characterized in getting involved has the calmness of lipoids, gathering of compound saccharide, then proliferation of fibrous tissue and calcific deposit, and has medial pathological changes。Primary disease mainly involves large-scale and medium-sized flesh elastic-type tremulous pulse, with aorta, coronary artery and cerebral arteries for common, often results in the serious consequence such as obliteration or tube wall Rupture haemorrhag。The atherosclerosis on coronary artery is occurred to be called coronary atherosclerosis (CoronaryAtherosclerotic)。It is the atherosclerosis that the outer coronary artery of modal stenosis coronary artery disease, particularly flesh wall props up。Coronary artery proximal section why start well pulse atherosclerosis be due to it than all organ tremulous pulsies all near ventricle, thus bear maximum contraction pressure and clash into。Furthermore, coronary arterial vessel tree has most direction to change due to the shape of heart, therefore also bears bigger blood flow shear stress。

Predilection site: according to the postmortem statistics of China, total recall rate of pathological changes, Stenosis and average rank are all the highest with anterior descending branch, and all the other are followed successively by right trunk, Left main artery or LC, posterior descending branch。Sex difference: 20～50 years old detection rate of pathological change, male is significantly higher than women；Men and women's no significant difference after 60 years old。

Atherosclerosis is to cause the basis of a series of heart, cerebrovascular, and we just carry out simply to tell about the mechanism of atherogenesis below。Oxided low-density lipoprotein (Ox-LDL) is atherosclerotic core, it is " Oxided low-density lipoprotein " abbreviation " Ox-LDL " after the low density lipoprotein, LDL (LDL) in blood is by free-radical oxidations such as active oxygens (ROS), he will intravasation wall, 1.Ox-LDL damages the endotheliocyte of blood vessel wall, and allows endotheliocyte gap become big；2.Ox-LDL stimulates mononuclear cell migration intravasation wall；3.OX-LDL is swallowed by the receptor of macrophage and the smooth muscle cell of blood vessel,----forming foam cell, 4.Ox-LDL makes above two foam cell necrosis disintegrate, forms rotten atheonecrosis thing, and atherosclerotic plaque is formed。

Here wanting ben is that Oxided low-density lipoprotein (Ox-LDL) has played central role in whole atherogenesis process, rather than " low density lipoprotein, LDL " or " blood fat " or " cholesterol " concept that we common people it is generally acknowledged, if LDL is not oxidized for Ox-LDL, the mononuclear cell of body thinks that LDL is " one of own side ", he (LDL) will not be swallowed and form foam cell, only after he (LDL) is oxidized to Ox-LDL, just thought [dissident] composition by inflammatory mediators such as the mononuclear cells of body, and it is swallowed, eliminate, ultimately form foam cell。Therefore prevent LDL to be oxidized to Ox-LDL and contain atherosclerotic key point, rather than we conventional understand reduction cholesterol, reduce blood fat, reduce low density lipoprotein, LDL (LDL) etc.。

Blood vessel after atherosclerosis, the formation of thrombosis is a more complicated inflammatory process。Growth along with above-mentioned atheromatous plaque, may often be such that and cause that above-mentioned foam cell is dead, form gangrenosum acne core, he can with the inflammatory reaction of sustainable existence, above-mentioned atherosclerotic plaque is made to become very unstable, the macrophages secrete one enzymatic degradation collagen fiber cap of activation, unstable spot is formed, and is thus easy to break。Speckle after breaking highly causes the substance release of blood coagulation in a large number and enters lumen of vessels, causes that local thrombus is formed。When this thrombosis is at the blood vessel of brain, then it is cerebral thrombosis (cerebral infarction, cerebral infarction), when cerebrovascular is in a weak position and with hypertension etc, or speckle breaks outside blood vessel and is the formation of cerebral hemorrhage, this two classes situation traditional Chinese medical science apoplexy, doctor trained in Western medicine apoplexy；When this thrombosis is at the coronary artery of heart, just it is myocardial infarction (myocardial infarction)；When this thrombosis occurs at Fundus oculi artery, then it it is exactly degeneration of macula。When the formation of this thrombosis occurs in artery of lower extremity time, the change of foot disease resulting in picture diabetes etc。

Application publication number CN102973786A(application number 201210441546.1) Chinese patent literature disclose a kind of Chinese medicine treating coronary atherosclerotic heart disease, it is made up of the crude drug of following weight parts: Radix Angelicae Sinensis 6-10 part, Radix Notoginseng 3-5 part, Radix Scrophulariae 6-8 part, Flos Lonicerae 12-15 part, Radix Cynanchi Atrati 5-9 part, Ganoderma 14-18 part, Semen Lepidii (Semen Descurainiae) 10-13 part, Cortex Mori 8-10 part, Lignum Dalbergiae Odoriferae 6-8 part, Rhizoma Corydalis 10-12 part, Radix Codonopsis 15-20 part, Radix Glycyrrhizae 5-20 part, Radix Ophiopogonis 15-20 part, Magnetitum 20-25 part。Application publication number CN103550624A(application number 201310524895.4) Chinese patent literature disclose a kind of Chinese medicine preparation treating atherosclerosis and coronary atherosclerosis, its primary raw material and weight portion respectively, Radix Angelicae Sinensis 30 parts, Rhizoma Chuanxiong 15 parts, the Radix Paeoniae Alba 18 parts, 30 parts of Fructus Hordei Germinatus, 12 parts of Flos Carthami, Thallus Laminariae (Thallus Eckloniae) 12 parts, Herba Menthae 10 parts, Folium Fumicis Dentati 30 parts, Rhizoma Phragmitis 30 parts。

In a word, Chinese medicine achieves good curative effect in treatment primary disease, but there is also some problems: also needing to synchronize research to preventing and treating coronary atherosclerosis clinically, the malaise symptoms curative effect that treatment coronary atherosclerosis is occurred also awaits further raising。

Summary of the invention

For the deficiencies in the prior art, it is an object of the invention to provide a kind of prepare simple, taking convenience, be easy to carry, the electuary of the easily treatment coronary atherosclerosis of clothes for a long time, this Chinese medicine composition determined curative effect and having no side effect。

The technical scheme is that

The electuary for the treatment of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion: Fructus Trichosanthis 6-9, Herba Agerati Conyzoidis 6-12, Ramulus Cinnamomi 6-10, Fructus Hippophae 2-8, Bulbus Allii Macrostemonis 6-15, Cortex Mori 3-6, Radix Salviae Miltiorrhizae 4-9, Mytilus 5-9, Radix Stemonae 2-5, Rhizoma Pinelliae 6-15, Polyporus 6-12, Rhizoma Alismatis 4-10, Oletum Trogopterori 3-9。

The electuary of foregoing treatment coronary atherosclerosis, it is preferred that be mainly prepared from by following bulk drugs, it is weight portion: Fructus Trichosanthis 7-8, Herba Agerati Conyzoidis 8-10, Ramulus Cinnamomi 7-9, Fructus Hippophae 4-6, Bulbus Allii Macrostemonis 9-12, Cortex Mori 4-5, Radix Salviae Miltiorrhizae 6-8, Mytilus 6-8, Radix Stemonae 3-4, Rhizoma Pinelliae 9-11, Polyporus 8-10, Rhizoma Alismatis 6-8, Oletum Trogopterori 5-7。

The electuary of foregoing treatment coronary atherosclerosis, more preferably preferably, is mainly prepared from by following bulk drugs, is weight portion: Fructus Trichosanthis 7.5, Herba Agerati Conyzoidis 9, Ramulus Cinnamomi 8, Fructus Hippophae 5, Bulbus Allii Macrostemonis 10, Cortex Mori 4.5, Radix Salviae Miltiorrhizae 7, Mytilus 7, the Radix Stemonae 3.5, the Rhizoma Pinelliae 10, Polyporus 9, Rhizoma Alismatis 7, Oletum Trogopterori 6。

The preparation method of the electuary of described treatment coronary atherosclerosis is:

(1) juice is decocted in the crude drug mixing put in order, decoct three times altogether, every time after water boils, decocting 0.8-1.4 hour, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, filters after precipitating 15-25 hour；

(2) filtrate is by thin film evaporation to every milliliter of suitable 4-5 gram of crude drug of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-3 gram, filters after precipitating 8-24 hour；

(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.05-1.2:1, lets cool to 80 DEG C hereinafter referred to as total solid；

(4) white sugar of total solid 2-5 times of weight is added, the dextrin (being preferably added to the dextrin of 0.9 times of weight) of 0.5-1.2 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging。

The preparation method of above-mentioned electuary, it is preferred that step (1) decocts 1-1.3 hour (preferably 1.2 hours) again。

The preparation method of above-mentioned electuary, it is preferred that step (1) filters (preferably 20 hours) after precipitating 18-23 hour。

The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, it is preferred that step (2) is evaporated to every milliliter of medicinal liquid suitable crude drug 4.2-4.8 gram (preferably 4.5 grams)。

The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, it is preferred that step (2) filters (preferably 15 hours) after precipitating 13-18 hour。

The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, it is preferred that step (4) adds the white sugar (preferably 3.5 times) of total solid 3-4 times of weight。

Present invention also offers the application when preparation treatment coronary atherosclerosis, myocardial infarction, myocardial necrosis, anginal medicine of the described electuary。

Instructions of taking: for making the present invention reach optimum efficiency, when taking, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of。

The pharmacology of the present invention main raw material of Chinese medicine used is as follows:

Fructus Trichosanthis: sweetness and bitterness, cold。Cheng Wuji: " bitter in the mouth, cold。Enter lung, stomach, large intestine channel。Function cures mainly: lung moistening, reduces phlegm, eliminating stagnation, intestine moistening。Control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quench one's thirst, jaundice, constipation, carbuncle from the beginning of。

Herba Agerati Conyzoidis: hardship pungent, micro-is cool。Function cures mainly: expelling wind and clearing away heat, pain relieving, hemostasis, calculus。For upper respiratory tract infection, tonsillitis, pharyngolaryngitis, acute gastroenteritis, stomachache, stomachache, metrorrhagia, renal calculus, vesical calculus；Eczema, thrush, ulcerative carbuncle toxic swelling, cellulitis, ulcer of the lower limb, otitis media, traumatic hemorrhage are controlled in external。

Ramulus Cinnamomi: nature and flavor: acrid, sweet, warm。Gui Jing: GUIXIN, lung, bladder warp。Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins。Cure mainly: for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass。

Fructus Hippophae: another name Da Er, Fructus Elaeagni Angustifoliae, fructus hippophae, big Er Buxing, vinegar willow, acid sting Liu Liu, sour, its examine a day Cannes, acid thorn, black thorn, yellow acid thorn, acid thorn sting, Fructus Hippophae and oil have significantly high medical value, cholesterol can be reduced, cure the effects such as angina pectoris, also have the effect preventing and treating coronary atherosclerotic heart disease；Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis；Gastric duodenal ulcer and dyspepsia etc. can be treated, the diseases such as chronic superficial gastritis, atrophic gastritis, colitis is evident in efficacy；To burn, scald, cutter burns, cold injury has good therapeutical effect；Cervical erosion is had good therapeutic effect。Sour in the mouth；Puckery；Warm in nature, relieving cough and resolving phlegm；Invigorating the stomach and promoting digestion；Promoting blood circulation to remove blood stasis。Main cough with copious phlegm；Pulmonary abscess；Dyspepsia；Abdominal pain due to retention of food；Stomachache；Enteritis；Amenorrhea；Traumatic injury congestive edema。

Bulbus Allii Macrostemonis: nature and flavor: pungent, bitter, temperature。Gui Jing: return lung, stomach, large intestine channel。Effect: activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving。Cure mainly: for thoracic obstruction pain, phlegm retention cough with asthma, heavy after letting out dysentery。

Cortex Mori: function cures mainly: dyspnea and cough due to lung-heat, diseases caused by retention of fluid stops lung, distension dyspnea with rapid respiration, is especially apt to purte the white and relievings asthma and cough, controls lung-heat cough with asthma, and expectorant is thick and yellow。The property of medicine: sweet in the mouth, micro-hardship, return lung, spleen channel。

Radix Salviae Miltiorrhizae: nature and flavor: bitter, is slightly cold。Gui Jing: GUIXIN, Liver Channel。Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness。Cure mainly: for menoxenia, amenorrhea dysmenorrhea, abdominal mass is gathered, chest and abdomen twinge, pyretic arthralgia pain, and skin infection swells and ache, dysphoria and insomnia；Hepatosplenomegaly, angina pectoris。

Mytilus: salty, temperature。Invigorating the liver and kidney, benefiting essence-blood, disappear goiter。Control asthenia weakness and emaciation, dizziness, night sweat, sexual impotence, lumbago, spit blood, metrorrhagia, leukorrhagia, goiter, hernia abdominal mass。Energy tonifying five ZANG-organs, Yiyang thing, manage waist beriberi, disappear dyspepsia, except cold air in abdomen, mass beside the umbilicus。

The Radix Stemonae: nature and flavor: sweet, bitter, tepor。Gui Jing: return lung meridian。Effect: nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing。Cure mainly: cough for new chronic cough, pulmonary tuberculosis cough, pertussis；Outer for head louse, body louse, enterobiasis, pudendal pruritus。Honey Radix Stemonae nourishing the lung to arrest cough。For deficiency of YIN chronic cough。

The Rhizoma Pinelliae: its acrid in the mouth, warm in nature, poisonous；Returning spleen, stomach, lung meridian, medical value tuber is used as medicine, poisonous, energy drying dampness to eliminate phlegm, and stopping nausea and vomiting by lowering the adverse flow of QI is raw with the furuncle and phyma that disappears；Cure mainly cough with copious phlegm, nausea and vomiting；Acute mastitis, acute and chronicization dense property otitis media are controlled in external。Effect: humidifying expectorant, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass。Controlling damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness。Outer subduing inflammation。Vexed, the globus hystericus disease for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, interior expectorant dizziness, vomiting regurgitation, breast gastral cavity painful abdominal mass；Raw with external treatment carbuncle sucutaneous nodule。Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI。

Polyporus: nature and flavor: sweet, light, flat。Gui Jing: return kidney, bladder warp。Effect: promoting diuresis to eliminate damp pathogen。Cure mainly: for dysuria, edema, have loose bowels, stranguria with turbid discharge, leukorrhagia。

Rhizoma Alismatis: nature and flavor: sweet, cold。Gui Jing: return kidney, bladder warp。Effect: diuresis, clearing away damp-heat。Cure mainly: for dysuria. edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria；Hyperlipidemia。

Oletum Trogopterori: sweet, temperature。Promoting blood circulation to remove blood stasis, parch to black stops blooding。Having a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, curing postpartum bleeding is suffered from abdominal pain；Parch to black controls metrostaxis；Traumatic injury, Serpentis, insect bite wound are controlled in external。

The present invention provides electuary scientific formula, and the preparation method of various dosage forms is simple, products obtained therefrom taking convenience, is easy to carry。In addition, the excellent results of the present invention is also manifested by:

1, selected materials is all Chinese medicine material, without any side effects；

2, this prescription complies fully with Chinese medicine principle and coronary atherosclerosis patients body and mind feature, under the premise of general principle, can have different prescription according to different crowd, and function is different。

3, medicine source is easy to get, and medical material is with low cost, it is possible to alleviate patient burden。

Detailed description of the invention

Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this。

Embodiment 1 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion (every part takes 10g): Fructus Trichosanthis 6, Herba Agerati Conyzoidis 6, Ramulus Cinnamomi 6, Fructus Hippophae 2, Bulbus Allii Macrostemonis 6, Cortex Mori 3, Radix Salviae Miltiorrhizae 4, Mytilus 5, the Radix Stemonae 2, the Rhizoma Pinelliae 6, Polyporus 6, Rhizoma Alismatis 4, Oletum Trogopterori 3。

The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:

(1) juice is decocted in the crude drug mixing put in order, decoct three times altogether, every time after water boils, decocting 0.8 hour, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, filters after precipitating 15 hours；

(2) filtrate is by thin film evaporation to every milliliter of suitable 4 grams of crude drugs of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-3 gram, filters after precipitating 8 hours；

(4) white sugar of 2 times of weight of total solid is added, the dextrin of 0.5 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging。

Model case one a: xx, male, 48 years old。Sensation of oppression over the chest with shortness of breath is had a surplus for 2 years, and sleep in evening every day all feels uncomfortable in chest very serious, all cannot fall asleep normally, be afraid of cold, cardiopalmus, extremities being not warm warm, fatigue and weak, lower limb swells the diseases such as the soreness of waist, chest pain radiating to the back。Going examination in hospital, Color Sonography to show backflow, exercise stress car is shown as positive, and angiography is shown as arteriosclerosis, and doctor takes electuary of the present invention。

Take the present embodiment 3 gained electuary, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of。Taking 20 days, uncomfortable in chest, the symptom such as breathe hard substantially alleviates, and fatigue and weak also alleviates, and the amount of receiving increases, spirit can, take 2 months, angiography is shown as normal, following the service 4 months, and malaise symptoms disappears, and patient's self-induction is fully recovered。

Embodiment 2 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion (every part takes 15g): Fructus Trichosanthis 9, Herba Agerati Conyzoidis 12, Ramulus Cinnamomi 10, Fructus Hippophae 8, Bulbus Allii Macrostemonis 15, Cortex Mori 6, Radix Salviae Miltiorrhizae 9, Mytilus 9, the Radix Stemonae 5, the Rhizoma Pinelliae 15, Polyporus 12, Rhizoma Alismatis 10, Oletum Trogopterori 9。

(1) juice is decocted in the crude drug mixing put in order, decoct three times altogether, every time after water boils, decocting 1.4 hours, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, filters after precipitating 25 hours；

(2) filtrate is by thin film evaporation to every milliliter of suitable 5 grams of crude drugs of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-3 gram, filters after precipitating 24 hours；

(4) white sugar of 5 times of weight of total solid is added, the dextrin of 1.2 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging。

Embodiment 3 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion (every part takes 25g): Fructus Trichosanthis 7, Herba Agerati Conyzoidis 8, Ramulus Cinnamomi 7, Fructus Hippophae 4, Bulbus Allii Macrostemonis 9, Cortex Mori 4, Radix Salviae Miltiorrhizae 6, Mytilus 6, the Radix Stemonae 3, the Rhizoma Pinelliae 9, Polyporus 8, Rhizoma Alismatis 6, Oletum Trogopterori 5。

(1) juice is decocted in the crude drug mixing put in order, decoct three times altogether, every time after water boils, decocting 1 hour, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, filters after precipitating 18 hours；

(2) filtrate is by thin film evaporation to every milliliter of suitable 4.2 grams of crude drugs of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-3 gram, filters after precipitating 13 hours；

(4) white sugar of 3 times of weight of total solid is added, the dextrin of 0.8 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging。

Model case two: Lu xx, the age: 46 years old；Sex: women；Main suit: 3 months uncomfortable in chest of intermittent chest pain；History of present illness: patient occurred without obvious inducement chest pain before 6 hours, for pain vexed after breastbone, in persistence, companion's back part radiation, without abdominal distention, without stomachache, without nausea and vomiting, without fear of cold heating, without cough and expectoration。Discussing: Color Sonography shows backflow, exercise stress car is shown as positive, and angiography is shown as arteriosclerosis。

Take the present embodiment 3 gained electuary, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of。Taking 20 days, chest pain is uncomfortable in chest substantially to be alleviated, and confusing in the heart also alleviates, and the amount of receiving increases, spirit can, take 1 month, symptom eliminates, peace of sleeping night, vexed removes, and strength increases, receive food can, following the service 2 months, any discomfort does not occur when patient takes, patient's self-induction is fully recovered。

Embodiment 4 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion (every part takes 5g): Fructus Trichosanthis 8, Herba Agerati Conyzoidis 10, Ramulus Cinnamomi 9, Fructus Hippophae 6, Bulbus Allii Macrostemonis 12, Cortex Mori 5, Radix Salviae Miltiorrhizae 8, Mytilus 8, the Radix Stemonae 4, the Rhizoma Pinelliae 11, Polyporus 10, Rhizoma Alismatis 8, Oletum Trogopterori 7。

(1) juice is decocted in the crude drug mixing put in order, decoct three times altogether, every time after water boils, decocting 1.3 hours, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, filters after precipitating 23 hours；

(2) filtrate is by thin film evaporation to every milliliter of suitable 4.8 grams of crude drugs of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-3 gram, filters after precipitating 18 hours；

(4) white sugar of 4 times of weight of total solid is added, the dextrin of 1 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging。

Model case three: yellow xx, 50 years old,, there is more acutely and frequently angina pectoris relatively in the past one day in man, and the anginosus time is longer, inducement is inconspicuous, but also uncomfortable in chest with the short time, symptom of breathing hard, family members takes pills for curing heart disease to solve this symptom to it, but curative effect is bad, goes large hospital to do and comprehensively check that above-mentioned symptom is caused by coronary atherosclerosis。

Take the present embodiment 4 gained electuary, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of。Taking 10 days, uncomfortable in chest, angina pectoris substantially alleviates, Nausea and vomiting transference cure, the amount of receiving increase, spirit can, take 20 days, electrocardio diagram coronary artery blood supply be obviously improved, following the service 3 months, patient fully recover。

Embodiment 5 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion (every part takes 20g): Fructus Trichosanthis 7.5, Herba Agerati Conyzoidis 9, Ramulus Cinnamomi 8, Fructus Hippophae 5, Bulbus Allii Macrostemonis 10, Cortex Mori 4.5, Radix Salviae Miltiorrhizae 7, Mytilus 7, the Radix Stemonae 3.5, the Rhizoma Pinelliae 10, Polyporus 9, Rhizoma Alismatis 7, Oletum Trogopterori 6。

(1) juice is decocted in the crude drug mixing put in order, decoct three times altogether, every time after water boils, decocting 1.2 hours, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, filters after precipitating 20 hours；

(2) filtrate is by thin film evaporation to every milliliter of suitable 4.5 grams of crude drugs of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-3 gram, filters after precipitating 15 hours；

(4) white sugar of 3.5 times of weight of total solid is added, the dextrin of 0.9 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging。

Test example 1 embodiment 5 gained treatment treatment coronary atherosclerosis electuary clinical practice: in June, 2010 in December ,-2013, screen 150 example patients in 4 hospitals, wherein women 100 example, male 50 example, oldest 72 years old, minimal ages 38 years old, 55.2 years old mean age。Before test 2 weeks, this crowd is carried out Continuous Observation, record symptom and change, it is randomly divided into two groups, experimental group and matched group, experimental group takes embodiment 5 products obtained therefrom, and matched group takes other medicine (conventional medication such as metoprolol, lignocaine, norepinephrine)。Using method is: each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of。Curative effect situation criterion: cure: take one course for the treatment of of this product, electrocardio diagram coronary artery blood supply is obviously improved, and malaise symptoms disappears, and energy and muscle power are remarkably reinforced；Effective: to take one course for the treatment of of this product, electrocardio diagram artery chronic blood supply improves, and malaise symptoms alleviates or partial disappearance, and energy and muscle power strengthen；Invalid: taking one course for the treatment of of this product, malaise symptoms is unchanged。Result is as shown in table 1。

Table 1: take embodiment 5 product 38-72 year coronary atherosclerosis patients therapeutic outcome

Table 1

Therapeutic effect: cure 95 examples (95%), effective percentage 98%。Effect is substantially better than matched group。

Take period self-induction symptom and muscle power change of spirit is as shown in table 2。

Table 2:

The present invention selects Fructus Trichosanthis, Herba Agerati Conyzoidis, Ramulus Cinnamomi, Fructus Hippophae, Bulbus Allii Macrostemonis, Cortex Mori, Radix Salviae Miltiorrhizae etc. to carry out compatibility so that producing synergism after these drug regimens, all medicines share, invigorate blood circulation and energy yin nourishing, blood stasis dispelling and just do not hinder, have one's ideas straightened out and QI invigorating of holding concurrently, therefore good therapeutic effect can be obtained。Taking 10 days, more than 53% feel takes a turn for the better to some extent, and malaise symptoms improves；Taking 20 days, more than 72% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen；Taking 30 days, more than 97% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and coronarography display tremulous pulse is normal, and some patients self-induction is fully recovered。Taking more than 30 days in experimental group, effective percentage is up to 93%, and matched group is only 76%。Electuary of the present invention has promoting blood circulation to restore menstrual flow, scattered silt analgesic efficacy, and with coronary heart disease, treatment atherosclerosis is had special curative effect。

Claims

1. treat the electuary of coronary atherosclerosis, it is characterized in that, be mainly prepared from by following bulk drugs, be weight portion: Fructus Trichosanthis 8, Herba Agerati Conyzoidis 10, Ramulus Cinnamomi 9, Fructus Hippophae 6, Bulbus Allii Macrostemonis 12, Cortex Mori 5, Radix Salviae Miltiorrhizae 8, Mytilus 8, the Radix Stemonae 4, the Rhizoma Pinelliae 11, Polyporus 10, Rhizoma Alismatis 8, Oletum Trogopterori 7。

2. the preparation method treating the electuary of coronary atherosclerosis according to claim 1, is characterized in that, step is as follows:

3. preparation method according to claim 2, is characterized in that, step (1) decocts 1-1.3 hour (preferably 1.2 hours) again。

4. preparation method according to claim 2, is characterized in that, step (1) filters (preferably 20 hours) after precipitating 18-23 hour。

5. preparation method according to claim 2, is characterized in that, step (2) is evaporated to every milliliter of medicinal liquid suitable crude drug 4.2-4.8 gram (preferably 4.5 grams)。

6. preparation method according to claim 2, is characterized in that, step (2) filters (preferably 15 hours) after precipitating 13-18 hour。

7. preparation method according to claim 2, is characterized in that, step (4) adds the white sugar (preferably 3.5 times) of total solid 3-4 times of weight。