CN105770646A - Electuary for treating coronary atherosclerosis - Google Patents
Electuary for treating coronary atherosclerosis Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses an electuary for treating coronary atherosclerosis. The electuary is mainly prepared from, by weight, 6-9 parts of Fructus Trichosanthis, 6-12 parts of Herba Agerati Conyzoidis, 6-10 parts of Ramulus Cinnamomi, 2-8 parts of Fructus Hippophae, 6-15 parts of Bulbus Allii Macrostemi, 3-6 parts of mulberry bark, 4-9 parts of Radix Salviae Milti orrhizae, 5-9 parts of dried mussel, 2-5 parts of Radix Stemonae, 6-15 parts of Rhizoma Pinelliae, 6-12 parts of Polyporus, 4-10 parts of Rhizoma Alismatis and 3-9 parts of Faeces Trogopterori. The electuary for treating the coronary atherosclerosis has the remarkable advantages that the electuary prepared from traditional Chinese medicines completely is free of any toxic or side effect; the formula completely conforms to the traditional Chinese medicine principle and physical and mental characteristics of patients with the coronary heart disease, and on the premise of the general principle, different formulas with different functions can be made to suit different patients; the electuary is capable of activating blood to promote menstruation and dissipating blood stasis to relieve pain and is remarkably effective in treatment of the atherosclerosis and the coronary heart disease.
Description
Divisional application, original applying number 2014100821592, applying date 2014.03.07, title treatment coronary artery congee sample
The electuary of hardening and preparation method.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind for the treatment of coronary atherosclerosis electuary and
Its preparation method.
Background technology
Atherosclerotic (Atherosclerosis) is type most common and important in artery sclerosis, is characterized in
The inner membrance of artery of getting involved has the calmness of lipoids, the accumulation of compound carbohydrate, proliferation of fibrous tissue and calcific deposit then, and has artery
The pathology in middle level.This disease mainly involves large-scale and medium-sized flesh elastic-type artery, with sustainer, coronary artery and cerebral artery for many
See, often result in the serious consequence such as obliteration or tube wall Rupture haemorrhag.The atherosclerotic on coronary artery is occurred to be referred to as
Coronary atherosclerosis (Coronary Atherosclerotic).It is modal stenosis coronary artery disease, special
It it not the atherosclerotic that outside flesh wall, coronary artery props up.Coronary artery proximal section start the best pulse atherosclerosis be due to
It is than all organ arteries all near ventricle, thus the contraction pressure bearing maximum is clashed into.Furthermore, coronary arterial vessel tree is due to the heart
Dirty shape and have most direction to change, the most also bear bigger blood flow shear stress.
Predilection site: according to the postmortem statistics of China, total recall rate, Stenosis and the average level of pathology all with
Descending anterior branch is the highest, and remaining is followed successively by right trunk, Left main artery or LC, posterior descending branch.Gender differences: 20～50 years old pathology detection
Rate, the male sex is significantly higher than women；Men and women's no significant difference after 60 years old.
Atherosclerotic is to cause the basis of a series of heart, cerebrovascular disease, and we just come simply to tell about below
The mechanism of atherogenesis.Oxided low-density lipoprotein (Ox-LDL) is atherosclerotic core, works as blood
In low-density lipoprotein (LDL) make " Oxided low-density lipoprotein " to be called for short after the free-radical oxidations such as active oxygen (ROS)
" Ox-LDL ", he will intravasation wall, 1.Ox-LDL damages the endothelial cell of vascular wall, and allows endothelial cell gap become
Greatly；2.Ox-LDL stimulates monocyte migration intravasation wall；3.OX-LDL is by macrophage and the smooth muscle cell of blood vessel
Acceptor swallowed,----formed foam cells, 4.Ox-LDL makes above two foam cells necrosis be disintegrated, formed gruel congee sample bad
Dead thing, AP is formed.
Here want especially it is emphasised that Oxided low-density lipoprotein (Ox-LDL) is in whole atherogenesis mistake
" low-density lipoprotein " or " blood fat " that Cheng Zhongqi central role rather than our common people it is generally acknowledged or " courage is solid
Alcohol " concept, if LDL is not oxidized for Ox-LDL, the monocyte of body thinks that LDL is " one of own side ", will not be to he (LDL)
Carry out swallowing and forming foam cells, only after he (LDL) is oxidized to Ox-LDL, just by inflammation such as the monocytes of body
Medium is considered [dissident] composition, and swallows it, eliminates, ultimately forms foam cells.Therefore LDL is prevented to be oxidized to
Ox-LDL is to contain atherosclerotic key point rather than our the reduction cholesterol of conventional understanding, reduction blood fat, fall
Low low-density lipoprotein (LDL) etc..
Blood vessel after atherosclerotic, the formation of thrombus is a more complicated inflammatory process.Along with above-mentioned artery
The growth of AP, may often be such that and cause above-mentioned foam cells dead, forming gangrenosum acne core, he can be with sustainable existence
Inflammatory reaction, makes above-mentioned AP become the most unstable, the macrophages secrete one enzyme degraded collagenous fibres of activation
Cap, Vulnerable plaque is formed, is thus easy to rupture.Patch after rupturing height in a large number causes the substance release of blood coagulation and enters blood vessel
Chamber, causes local thrombus to be formed.When this thrombosis is at the blood vessel of brain, then it is cerebral thrombus (cerebral infarction, cerebral infarction), works as brain
Blood vessel is in a weak position and with hypertension etc, or patch ruptures outside blood vessel and is the formation of cerebral hemorrhage,
This two classes situation traditional Chinese medical science apoplexy, doctor trained in Western medicine palsy；When this thrombosis is at the coronary artery of heart, just it is myocardial infarction
(miocardial infarction)；When this thrombosis occurs at Fundus oculi artery, then it it is exactly macular degeneration.When the formation of this thrombus occurs in
The when of artery of lower extremity, the change of foot disease resulting in picture diabetes etc.
Application publication number CN 102973786 A(application number 201210441546.1) Chinese patent literature disclose
A kind of Chinese medicine treating coronary atherosclerotic heart disease, is made up of the bulk drug of following weight parts: Radix Angelicae Sinensis 6-10 part,
Pseudo-ginseng 3-5 part, radix scrophulariae 6-8 part, honeysuckle 12-15 part, radix cynanchi atrati 5-9 part, glossy ganoderma 14-18 part, lepidium seed 10-13 part,
Root bark of white mulberry 8-10 part, dalbergia wood 6-8 part, corydalis tuber 10-12 part, Radix Codonopsis 15-20 part, Radix Glycyrrhizae 5-20 part, the tuber of dwarf lilyturf 15-20
Part, magnetite 20-25 part.Application publication number CN 103550624 A(application number 201310524895.4) Chinese patent literary composition
Offering and disclose a kind of Chinese medicine preparation treating atherosclerotic and coronary atherosclerosis, its primary raw material and weight portion divide
Not, Radix Angelicae Sinensis 30 parts, rhizome of chuanxiong 15 parts, the root of herbaceous peony 18 parts, 30 parts of Fructus Hordei Germinatus, 12 parts of safflower, kelp 12 parts, peppermint 10 parts, ox
Tongue grass 30 parts, reed rhizome 30 parts.
In a word, traditional Chinese medicine achieves preferable curative effect at treatment this disease aspect, but there is also some problems: clinically to anti-
Controlling coronary atherosclerosis also to need to synchronize research, malaise symptoms curative effect treatment coronary atherosclerosis occur also needs
In improving further.
Summary of the invention
For the deficiencies in the prior art, it is an object of the invention to provide one prepare simply, taking convenience, be easy to carry,
The easily for a long time electuary of the treatment coronary atherosclerosis of clothes, this Chinese medicine composition determined curative effect and having no side effect.
The technical scheme is that
The electuary for the treatment of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion: Snakegourd Fruit 6-9, victory
Red Ji 6-12, cassia twig 6-10, sea-buckthorn 2-8, Longstamen Onion Bulb 6-15, mulberry skin 3-6, red sage root 4-9, mussel 5-9, tuber of stemona 2-5, tuber of pinellia 6-15,
Umbellate pore furgus 6-12, rhizoma alismatis 4-10, excrementum pteropi 3-9.
The electuary of foregoing treatment coronary atherosclerosis, it is preferred that main preparation by following bulk drugs and
Become, be weight portion: Snakegourd Fruit 7-8, Ageratum conyzoides 8-10, cassia twig 7-9, sea-buckthorn 4-6, Longstamen Onion Bulb 9-12, mulberry skin 4-5, red sage root 6-8 are light
Dish 6-8, tuber of stemona 3-4, tuber of pinellia 9-11, umbellate pore furgus 8-10, rhizoma alismatis 6-8, excrementum pteropi 5-7.
The electuary of foregoing treatment coronary atherosclerosis, the most preferably, mainly by following bulk drugs system
Standby form, be weight portion: Snakegourd Fruit 7.5, Ageratum conyzoides 9, cassia twig 8, sea-buckthorn 5, Longstamen Onion Bulb 10, mulberry skin 4.5, the red sage root 7, mussel 7, the tuber of stemona
3.5, the tuber of pinellia 10, umbellate pore furgus 9, rhizoma alismatis 7, excrementum pteropi 6.
The preparation method of the electuary of described treatment coronary atherosclerosis is:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 0.8-1.4 hour, cross leaching
Juice, concoction merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding,
Filter after precipitating 15-25 hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4-5 gram of crude drug of liquid, adds cold water and is diluted to every milliliter contained 1-3
Gram, filter after precipitating 8-24 hour；
(3) filtrate is 1.05-1.2:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C the most admittedly
The scale of construction；
(4) adding the white granulated sugar of total solid 2-5 times weight, the dextrin of 0.5-1.2 times of weight (is preferably added to the paste of 0.9 times of weight
Essence), with ethanol (65%), regulate humidity, make particle with granulator, packaging.
The preparation method of above-mentioned electuary, it is preferred that step (1) decocts 1-1.3 hour (preferably 1.2 hours) again.
The preparation method of above-mentioned electuary, it is preferred that step (1) filters (preferably 20 hours) after precipitating 18-23 hour.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, it is preferred that step (2) is evaporated to every milliliter
Liquid suitable crude drug 4.2-4.8 gram (preferably 4.5 grams).
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, it is preferred that precipitation 13-18 is little for step (2)
(preferably 15 hours) are filtered time after.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, it is preferred that step (4) adds total solid 3-
The white granulated sugar (preferably 3.5 times) of 4 times of weight.
Present invention also offers described electuary at preparation treatment coronary atherosclerosis, miocardial infarction, myocardial necrosis, the heart
The application during medicine of angina.
Instructions of taking: for making the present invention reach optimum efficiency, when taking, each one bag, three times a day, and warm boiled water, 10
It course for the treatment of.
Used by the present invention, the pharmacology of main Chinese medicine material is as follows:
Snakegourd Fruit: sweetness and bitterness, cold.Cheng Wuji: " bitter, cold.Enter lung, stomach, large intestine channel.Function cures mainly: moistening lung, reduces phlegm, dissipating bind, ease constipation.
Control phlegm-heat cough, the obstruction of qi in the chest, accumulation of pathogens in chest, consumptive lung disease hemoptysis, quench one's thirst, jaundice, constipation, carbuncle swollen from the beginning of.
Ageratum conyzoides: hardship pungent, micro-is cool.Function cures mainly: expelling wind and clearing away heat, pain relieving, hemostasis, arranges stone.For the infection of the upper respiratory tract,
Tonsillitis, sphagitis, acute gastroenteritis, stomachache, stomachache, uterine bleeding, kidney stone, vesical calculus；Eczema is controlled in external application, thrush,
Ulcerative carbuncle pyogenic infections, cellulitis, the ulcer of lower limb, tympanitis, traumatism and bleeding.
Cassia twig: nature and flavor: acrid, sweet, warm.Gui Jing: the thoughts of returning home, lung, bladder warp.Effect: sweating expelling pathogenic factors from muscles and skin, warming meridian, supporing yangization
Gas, the flat gas that spins.Cure mainly: for anemofrigid cold, coldness and pain in the epigastrium, blood is cold through closing, joint pain, phlegm and retained fluid, oedema, and palpitaition is run quickly
Globefish.
Sea-buckthorn: another name Da Er, arrow-leaved oleaster, fructus hippophae, big Er Buxing, vinegar willow, acid sting Liu Liu, sour, its examine a day Cannes, acid thorn,
Black thorn, yellow acid thorn, acid thorn thorn, fructus hippophae and oil have the highest medical value, it is possible to decrease cholesterol, cure angina pectoris etc. and make
With, also prevent and treat the effect of coronary atherosclerotic heart disease；Have and eliminate the phlegm, cough-relieving, relieving asthma and treat chronic bronchitis
Effect；Gastric duodenal ulcer and indigestion etc. can be treated, to chronic superficial gastritis, atrophic gastritis, colitis
Evident in efficacy etc. illness；To burn, scald, cutter burns, frostbite has good therapeutic action；Cervical erosion is had good controlling
Therapeutic effect.Taste acid；Puckery；Warm in nature, relieving cough and reducing sputum；Stomach strengthening and digestion promoting；Promoting blood circulation to remove blood stasis.Main coughing with a lot of sputum；Pulmonary abscess；Indigestion；Food
Long-pending stomachache；Stomachache；Enteritis；Amenorrhoea；Fall dozen stasis of blood to swell.
Longstamen Onion Bulb: nature and flavor: pungent, bitter, temperature.Gui Jing: return lung, stomach, large intestine channel.Effect: activate yang and remove abstruction, promoting the circulation of qi is led stagnant.Main
Controlling: for obstruction of qi in the chest pain, phlegm and retained fluid is coughed and is breathed heavily, and lets out weight after dysentery.
Mulberry skin: function cures mainly: dyspnea and cough due to lung-heat, water drink stops lung, and turgor breathes heavily urgency, is especially apt to purte the white and relievings asthma and cough, controls lung heat and cough
Breathing heavily, phlegm is thick and yellow.The property of medicine: taste hardship sweet, micro-, return lung, the spleen channel.
The red sage root: nature and flavor: bitter, is slightly cold.Gui Jing: the thoughts of returning home, Liver Channel.Effect: stasis-dispelling and pain-killing, invigorates blood circulation and stimulates the menstrual flow, and clear away heart-fire relieving restlessness.Main
Controlling: for irregular menstruation, through closing dysmenorrhoea, lump in the abdomen is gathered, and chest and abdomen shouting pain, hot numbness pain, sore swells and ache, dysphoria and insomnia；Liver spleen swells
Greatly, angina pectoris.
Mussel: salty, temperature.Filling liver kidney, benefiting essence-blood, disappear goiter and tumor.Control consumptive disease thin thin, dizziness, night sweat, impotence, pain in the back, spit blood,
Uterine bleeding, under band, goiter and tumor, hernia lump in the abdomen.Energy tonifying five zang organs, Yiyang thing, manage waist tinea pedis, disappear place food, except cold air in abdomen, Xuan addiction.
The tuber of stemona: nature and flavor: sweet, bitter, tepor.Gui Jing: return lung channel.Effect: moistening lung to lower qi cough-relieving, desinsection.Cure mainly: for new long
Cough, pulmonary tuberculosis cough, pertussis；Outer for head louse, body louse, enterobiasis, pruritus vulvae.The honey tuber of stemona moistens the lung and relieve the cough.Cough for deficiency of Yin labor.
The tuber of pinellia: its taste is pungent, warm in nature, poisonous；Returning spleen, stomach, lung channel, medical value stem tuber is used as medicine, poisonous, can be eliminating dampness and eliminating phlegm,
Stopping nausea and vomiting by lowering the adverse flow of QI, raw with the furuncle that disappears；Cure mainly coughing with a lot of sputum, n and V；Acute mastitis, acute and chronicization dense property middle ear are controlled in external application
Scorching.Effect: humidifying phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control wet phlegm cold drink, vomiting, gastric disorder causing nausea, cough that to breathe heavily phlegm many, chest diaphragm turgor,
Coma due to blocking of the respiratory system is had a headache, dizzy egersis.Outer subduing inflammation.Cough for phlegm more breathe heavily, phlegm and retained fluid dizzy is throbbed with fear, interior phlegm dizziness, vomiting gastric disorder causing nausea, chest gastral cavity ruffian are vexed,
Globus hysteriocus disease；Raw swell subcutaneous nodule with controlling outward carbuncle.Pinellia is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Umbellate pore furgus: nature and flavor: sweet, light, flat.Gui Jing: return kidney, bladder warp.Effect: clearing damp and promoting diuresis.Cure mainly: for difficult urination,
Oedema, has loose bowels, stranguria with turbid discharge, under band.
Rhizoma alismatis: nature and flavor: sweet, cold.Gui Jing: return kidney, bladder warp.Effect: diuresis, clearing away damp-heat.Cure mainly: for urine not
Profit. oedema turgor, oliguria of having loose bowels, phlegmatic vertigo, heat drenches puckery pain；High fat of blood.
Excrementum pteropi: sweet, temperature.Promoting blood circulation to remove blood stasis, fries charcoal hemostasis.Having a pain for trusted subordinate's extravasated blood, dysmenorrhoea, blood stasis is through closing, and postpartum becomes silted up
Hemoperitoneum pain；Fry charcoal and control metrostaxis；Traumatic injury, snake, insect bite wound are controlled in external application.
The present invention provides electuary scientific formula, and the preparation method of various formulations is simple, products obtained therefrom taking convenience, is easy to take
Band.In addition, the excellent results of the present invention is also manifested by:
1, selected materials is all traditional Chinese medicine material, without any side effects；
2, this prescription complies fully with traditional Chinese medicine principle and coronary atherosclerosis patients body and mind feature, in the premise of general principle
Under, can there is different prescription according to different crowd, function is different.
3, medicine source is easy to get, and medicinal material is with low cost, it is possible to alleviate patient burden.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
Embodiment 1 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight
Part (every part takes 10g): Snakegourd Fruit 6, Ageratum conyzoides 6, cassia twig 6, sea-buckthorn 2, Longstamen Onion Bulb 6, mulberry skin 3, the red sage root 4, mussel 5, the tuber of stemona 2, the tuber of pinellia 6,
Umbellate pore furgus 6, rhizoma alismatis 4, excrementum pteropi 3.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 0.8 hour, cross leaching juice, medicine
Juice merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, precipitates 15
Filter after hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4 grams of crude drugs of liquid, adds cold water and is diluted to every milliliter contained 1-3 gram,
Filter after precipitating 8 hours；
(3) filtrate is 1.05-1.2:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C the most admittedly
The scale of construction；
(4) add the white granulated sugar of 2 times of weight of total solid, the dextrin of 0.5 times of weight, with ethanol (65%), regulate humidity, use
Particle made by grain machine, packaging.
Model case one a: xx, the male sex, 48 years old.Uncomfortable in chest breathing hard 2 years is had a surplus, evening every day sleep all feel uncomfortable in chest very
Severity, all cannot fall asleep normally, is afraid of cold, palpitaition, four limbs owe warm, fatigue and weak, and leg swells the diseases such as the soreness of waist, chest pain radiating to the back.Go
Examination in hospital, Color Sonography shows backflow, and exercise stress car is shown as positive, and angiography is shown as artery sclerosis, doctor
Take electuary of the present invention.
Take the present embodiment 3 gained electuary, each one bag, three times a day, and warm boiled water, 10 days courses for the treatment of.Take 20
My god, uncomfortable in chest, the symptom such as breathe hard substantially alleviates, and fatigue and weak also alleviates, and the amount of receiving increases, spirit can, take 2 months, angiography shows
Being shown as normal, following the service 4 months, malaise symptoms disappears, and patient's self-induction is fully recovered.
Embodiment 2 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion
(every part takes 15g): Snakegourd Fruit 9, Ageratum conyzoides 12, cassia twig 10, sea-buckthorn 8, Longstamen Onion Bulb 15, mulberry skin 6, the red sage root 9, mussel 9, the tuber of stemona 5, the tuber of pinellia
15, umbellate pore furgus 12, rhizoma alismatis 10, excrementum pteropi 9.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 1.4 hours, cross leaching juice, medicine
Juice merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, precipitates 25
Filter after hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 5 grams of crude drugs of liquid, adds cold water and is diluted to every milliliter contained 1-3 gram,
Filter after precipitating 24 hours；
(3) filtrate is 1.05-1.2:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C the most admittedly
The scale of construction；
(4) add the white granulated sugar of 5 times of weight of total solid, the dextrin of 1.2 times of weight, with ethanol (65%), regulate humidity, use
Particle made by grain machine, packaging.
Embodiment 3 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion
(every part takes 25g): Snakegourd Fruit 7, Ageratum conyzoides 8, cassia twig 7, sea-buckthorn 4, Longstamen Onion Bulb 9, mulberry skin 4, the red sage root 6, mussel 6, the tuber of stemona 3, the tuber of pinellia 9, pig
Siberian cocklebur 8, rhizoma alismatis 6, excrementum pteropi 5.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 1 hour, cross leaching juice, concoction
Merging, by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, and precipitation 18 is little
Filter time after；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4.2 grams of crude drugs of liquid, adds cold water and is diluted to every milliliter contained 1-3
Gram, filter after precipitating 13 hours；
(3) filtrate is 1.05-1.2:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C the most admittedly
The scale of construction；
(4) add the white granulated sugar of 3 times of weight of total solid, the dextrin of 0.8 times of weight, with ethanol (65%), regulate humidity, use
Particle made by grain machine, packaging.
Model case two: Lu xx, the age: 46 years old；Sex: women；Main suit: 3 months uncomfortable in chest of intermittent pectoralgia；Present illness history:
Patient occurred before 6 hours that for pain vexed after breastbone, in continuation, companion's back part radiation, without abdominal distension, without abdomen without obvious inducement pectoralgia
Bitterly, without n and V, generate heat without chilly, without cough and expectoration.Discuss: Color Sonography shows backflow, and exercise stress car is shown as
The positive, angiography is shown as artery sclerosis.
Take the present embodiment 3 gained electuary, each one bag, three times a day, and warm boiled water, 10 days courses for the treatment of.Take 20
My god, pectoralgia is uncomfortable in chest substantially to be alleviated, and the most confusing also alleviates, and the amount of receiving increases, spirit can, take 1 month, symptom eliminates, peace of sleeping night, the heart
Tired removing, strength increases, receive food can, following the service 2 months, any discomfort does not occurs when patient takes, patient's self-induction is fully recovered.
Embodiment 4 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight
Part (every part takes 5g): Snakegourd Fruit 8, Ageratum conyzoides 10, cassia twig 9, sea-buckthorn 6, Longstamen Onion Bulb 12, mulberry skin 5, the red sage root 8, mussel 8, the tuber of stemona 4, the tuber of pinellia
11, umbellate pore furgus 10, rhizoma alismatis 8, excrementum pteropi 7.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 1.3 hours, cross leaching juice, medicine
Juice merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, precipitates 23
Filter after hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4.8 grams of crude drugs of liquid, adds cold water and is diluted to every milliliter contained 1-3
Gram, filter after precipitating 18 hours；
(3) filtrate is 1.05-1.2:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C the most admittedly
The scale of construction；
(4) add the white granulated sugar of 4 times of weight of total solid, the dextrin of 1 times of weight, with ethanol (65%), regulate humidity, use particle
Particle made by machine, packaging.
Model case three: yellow xx, 50 years old, man, one day, more acutely and frequently angina pectoris occurred relatively in the past, angina pectoris is held
The continuous time is the longest, and inducement is inconspicuous, but also uncomfortable in chest with the short time, symptom of breathing hard, family members takes to it and rescues the heart
Ball solves this symptom, but curative effect is bad, goes large hospital to do comprehensively and checks that above-mentioned symptom is to be drawn by coronary atherosclerosis
Rise.
Take the present embodiment 4 gained electuary, each one bag, three times a day, and warm boiled water, 10 days courses for the treatment of.Take 10
My god, uncomfortable in chest, angina pectoris substantially alleviates, Nausea and vomiting transference cure, the amount of receiving increase, spirit can, take 20 days, electrocardio diagram crown
Artery blood supply is obviously improved, following the service 3 months, and patient fully recovers.
Embodiment 5 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight
Part (every part takes 20g): Snakegourd Fruit 7.5, Ageratum conyzoides 9, cassia twig 8, sea-buckthorn 5, Longstamen Onion Bulb 10, mulberry skin 4.5, the red sage root 7, mussel 7, the tuber of stemona 3.5,
The tuber of pinellia 10, umbellate pore furgus 9, rhizoma alismatis 7, excrementum pteropi 6.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 1.2 hours, cross leaching juice, medicine
Juice merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, precipitates 20
Filter after hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4.5 grams of crude drugs of liquid, adds cold water and is diluted to every milliliter contained 1-3
Gram, filter after precipitating 15 hours；
(3) filtrate is 1.05-1.2:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C the most admittedly
The scale of construction；
(4) add the white granulated sugar of 3.5 times of weight of total solid, the dextrin of 0.9 times of weight, with ethanol (65%), regulate humidity, use
Granulator makes particle, packaging.
The clinical practice of test example 1 embodiment 5 gained treatment treatment coronary atherosclerosis electuary: in June, 2010-
In December, 2013, screen 150 example patients, wherein women 100 example in 4 hospitals, the male sex 50 example, oldest 72 years old, minimum
38 years old age, 55.2 years old mean age.Before test 2 weeks, this crowd is carried out Continuous Observation, record symptom and change, at random
Being divided into two groups, experimental group and control group, experimental group takes embodiment 5 products obtained therefrom, and control group takes other medicine (Mei Tuoluo
The conventional medication such as that, lidocaine, norepinephrine).Using method is: each one bag, three times a day, warm boiled water, 10
It course for the treatment of.Curative effect situation criterion: cure: take one course for the treatment of of this product, electrocardio diagram coronary artery blood supply substantially changes
Kind, malaise symptoms disappears, and energy and muscle power are remarkably reinforced；Effective: to take one course for the treatment of of this product, electrocardio diagram artery chronic
Blood supply improves, and malaise symptoms alleviates or partial disappearance, and energy and muscle power strengthen；Invalid: to take one course for the treatment of of this product, malaise symptoms
Unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 38-72 year coronary atherosclerosis patients treatment results
Table 1
Result for the treatment of: cure 95 examples (95%), efficient 98%.Effect is substantially better than control group.
Take period self-induction symptom and muscle power spirit change is as shown in table 2.
Table 2:
The present invention selects Snakegourd Fruit, Ageratum conyzoides, cassia twig, sea-buckthorn, Longstamen Onion Bulb, mulberry skin, the red sage root etc. to carry out compatibility so that these drug regimens
Rear producing synergy, all medicines share, invigorate blood circulation and can yin-nourishing, the stasis of blood of dispelling and just do not hinder, have one's ideas straightened out and benefit gas of holding concurrently, therefore can obtain good
Result for the treatment of.Taking 10 days, more than 53% feel has taken a turn for the better, and malaise symptoms improves；Take 20 days, more than 72% feel have
Being taken a turn for the better, malaise symptoms improves or disappears, and spirit, muscle power strengthen；Taking 30 days, more than 97% feel has taken a turn for the better, uncomfortable disease
Shape improves or disappears, and spirit, muscle power strengthen, and coronarography display artery is normal, and some patients self-induction is fully recovered.In experimental group
Take more than 30 days, efficient up to 93%, and control group is only 76%.Electuary of the present invention has to invigorate blood circulation and stimulates the menstrual flow, and scattered silt is only
Effect bitterly, has special curative effect to treatment atherosclerotic with coronary heart disease.
Claims (7)
1. treat the electuary of coronary atherosclerosis, it is characterized in that, be mainly prepared from by following bulk drugs, be weight
Part: Snakegourd Fruit 6, Ageratum conyzoides 6, cassia twig 6, sea-buckthorn 2, Longstamen Onion Bulb 6, mulberry skin 3, the red sage root 4, mussel 5, the tuber of stemona 2, the tuber of pinellia 6, umbellate pore furgus 6, rhizoma alismatis 4,
Excrementum pteropi 3.
The most according to claim 1, treat the preparation method of the electuary of coronary atherosclerosis, it is characterized in that, step is such as
Under:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 0.8-1.4 hour, cross leaching
Juice, concoction merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding,
Filter after precipitating 15-25 hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4-5 gram of crude drug of liquid, adds cold water and is diluted to every milliliter contained 1-3
Gram, filter after precipitating 8-24 hour；
(3) filtrate is 1.05-1.2:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C the most admittedly
The scale of construction；
(4) adding the white granulated sugar of total solid 2-5 times weight, the dextrin of 0.5-1.2 times of weight (is preferably added to the paste of 0.9 times of weight
Essence), with ethanol (65%), regulate humidity, make particle with granulator, packaging.
Preparation method the most according to claim 2, is characterized in that, step (1) decocts 1-1.3 hour (preferably 1.2 hours) again.
Preparation method the most according to claim 2, is characterized in that, step (1) filters (preferably 20 after precipitating 18-23 hour
Hour).
Preparation method the most according to claim 2, is characterized in that, step (2) is evaporated to every milliliter of suitable crude drug of liquid
4.2-4.8 gram (preferably 4.5 grams).
Preparation method the most according to claim 2, is characterized in that, step (2) filters (preferably 15 after precipitating 13-18 hour
Hour).
Preparation method the most according to claim 2, is characterized in that, step (4) adds the white granulated sugar of total solid 3-4 times weight
(preferably 3.5 times).
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679904A (en) * | 2005-01-12 | 2005-10-12 | 王振球 | Chinese medicine for treating cardiac failure |
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2014
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679904A (en) * | 2005-01-12 | 2005-10-12 | 王振球 | Chinese medicine for treating cardiac failure |
Non-Patent Citations (2)
| Title |
|---|
| 余洪刚等: "温阳补心汤配合西药治疗慢性心力衰竭34例", 《陕西中医》 * |
| 苟奎斌: "我们对冲剂的改进", 《中国医院药学杂志》 * |
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