CN103735741B - A kind of Chinese medicine composition for the treatment of goat - Google Patents
A kind of Chinese medicine composition for the treatment of goat Download PDFInfo
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Abstract
A kind of Chinese medicine composition for the treatment of goat disclosed by the invention, relate to biological medicine technology field, to be mixed by following raw material by weight: tea polysaccharide 40-55, cherry powder 10-15, bark of ash powder 5-10, tea seed extract 3-6, root of Dahurain angelica powder 4-6, kudzu-vine root powder 10-15, radix cyathulae powder 3-8, described tea seed extract is to be mixed by unrighted acid 50-70, squalene 10-40, Tea Polyphenols 1.5-3 by weight; There is heat-clearing dredging collateral, swelling and pain relieving, dispel rheumatism, clearing away damp-heat, stopping numbness pain, by the stasis of blood stimulate the menstrual flow, easing joint movement, strengthen the effects such as body immunity, be used for the treatment of goat, the goat patient who is applicable to all ages and classes and sex takes.
Description
Technical field
The present invention relates to biological medicine technology field, particularly a kind of Chinese traditional medicine composition for the treatment of goatThing.
Background technology
Gout is a kind of because biosynthesis of purine metabolism increase, uric acid produce too much or because of uric acid excretionBad and in hyperamization uric acid raise, urate crystal is deposited on synovium of joint, synovial bursa cartilage and other groupsThe repeated relapsing inflammatory disease causing in knitting. At present, for the treatment of gout, doctor trained in Western medicine is mainAdopt colchicin, phenylbutazone or crovaril, indocin, brufen, feldene, naphthalene generalLife and ACTH and prednisone, benemid (probenecid), sulfinpyrazone, Benzbromarone, different purineThe medicines such as alcohol. Chinese patent (number of patent application is 200810159269.9) " medicament for the treatment of gout ",It is by, Semen Strychni (processed), the root of Chinese wild ginger, the root of Dahurain angelica, corydalis tuber, raw bark of eucommia, teasel root, radix cyathulae, slender acanthopanaxSkin, cultivated land, the fruit of Chinese wolfberry, parasitic loranthus, the root of Chinese clematis, bark of ash, notopterygium root, earthworm, pseudo-ginseng, Radix Angelicae Sinensis,Windproof, frankincense, myrrh, dragon's blood, lopseed, the red sage root, tortoiseshell, turtle shell, fish fat composition. OnSide also can add levisticum, wild aconite root, aconiti preparata,radix; Having cold can add monkshood, rhizoma zingiberis, deer horn glue, as weight in wet baseCan add long-noded pit viper, Common St.Paulswort Herb; As pain very adds centipede, scorpio, leech. Advantage of the present invention is, curative effectShowing, efficient 76%, cure rate is more than 55%. And for example (number of patent application is Chinese patent200510010521.6) " tincture for the treatment of pain, wind-cold-dampness arthralgia ", it is pinke needle oil 5KG, slender acanthopanaxSkin extract 5KG, lycopodium calvatum, the root of Chinese clematis, bark of ash, earthworm, lopseed, hookedspine bittersweet root fruit or stem, greyArt, levisticum, elecampane, Chinese pepper, pointed at both ends, rhizoma cyperi, fennel, Artemisia anomala, Rhizoma Sparganii, golden cypress,Cnidium officinale makino, safflower, rhizoma Gastrodiae, earthworm, windproof, Chinese ephedra, the root of Dahurain angelica, peppermint, ramulus mori, semen brassicae,The root bark of shaggy-fruited dittany, elder, false spiraea, rabbit umbrella, leontice robustumDiels, Wyrmslayer, the fruit of summer cypress, parasitism andThe each 1KG of corydalis tuber, Korean aconite roof, rhizoma arisaematis, Typhonium giganteum, the achene of Siberian cocklebur, japanese angelica tree, pig Xian, north grassThe each 0.5KG of crow, ground bettle, spina gleditsiae, snake slough, castor-oil plant, honeycomb and frutus cnidii alcohol 95%50KG,In asccharin 5ML and essence 5ML, soak the extract obtaining for 2-3 month. Product of the present invention can be sent outWave and dispel rheumatism, eliminating cold to stop pain, activate blood circulation and disperse blood clots, stimulate the menstrual flow and adjust network, detumescence to separate the effect of disease. In also havingState's patent (number of patent application is 201110027145.7) " a kind of Chinese medicine and preparation thereof for the treatment of goutMethod ", the raw material composition percentage by weight of making its active ingredient is: the Radix Astragali, Radix Angelicae Sinensis, corn stigma,Cordyceps sinensis, cherry, caulis trachelospermi, the root of kudzu vine, levisticum, dried human placenta extract powder 25-35, xylitol 20-30,Filler 40-50; There is relieving muscles to expel heat, promote the production of body fluid quench one's thirst, invigorating qi for strengthening superficies, diuresis holder poison, the work of enriching bloodBlood, warm kidney are mended essence, nourishing qi and blood, are invigorated the lung and the kidney, dissipating phlegm and removing blood stasis, dispel rheumatism, numbness relieving and pain relieving,The effects such as clearing liver cholagogic, dispelling wind and removing obstruction in the meridians, cool blood detumescence, can be used for treating multiple gout.
Summary of the invention
Technical problem to be solved by this invention is to provide one to be had heat-clearing dredging collateral, swelling and pain relieving, dispelsWind dehumidifying, clearing away damp-heat, stopping numbness pain, by the stasis of blood stimulate the menstrual flow, easing joint movement, strengthen the merits such as body immunityImitate, can treat the Chinese medicine composition of goat.
The technical solution used in the present invention be invention a kind of Chinese medicine composition for the treatment of goat, be byFollowing raw material by weight mixes:
Tea polysaccharide 40-55 cherry powder 10-15 bark of ash powder 5-10
Tea seed extract 3-6 root of Dahurain angelica powder 4-6 kudzu-vine root powder 10-15
Radix cyathulae powder 3-8;
Described tea seed extract is to be mixed by following material by weight:
Unrighted acid 50-70 squalene 25-40 Tea Polyphenols 1.5-3;
Wherein, in unrighted acid, the percentage by weight of each composition is:
Oleic acid 50-70 linoleic acid 10-20 leukotrienes 10-20.
Described cherry powder is pulverized the cherry powder of rear gained by cherry pulp, or by following method preparationForm:
A, stoning: get fresh cherry, remove peach kernel, obtain cherry pulp;
B, making beating: cherry pulp is dropped into making beating together with accounting for the clear water of cherry pulp weight 30-50%In machine, break into 40-80 object cherry juice;
C, alcohol soak: in cherry juice, add edible ethanol, limit edged stirs, to the volume of ethanolAfter concentration is 60-80%, be to soak 30-45min at 45-70 DEG C in temperature, cross 60-100 mesh sieve,Obtain respectively alcohol immersion liquid and cherry pulp slag;
D, water extraction: to the boiling water that adds 2-3 times of weight in cherry pulp slag, stir evenly, under normal pressureLeave standstill to water temperature and be down to 30-45 DEG C, cross 100-140 mesh sieve, obtain falsesour cherry fruit-juice extract;
E, falsesour cherry fruit-juice extract concentrate: be that 0.6-0.8MPa, temperature are by falsesour cherry fruit-juice extract in vacuumAt 60-80 DEG C, being concentrated into solid content in every 100ml liquid is 5-8g, obtains cherry water extracting liquid;
F, alcohol immersion liquid concentrate: be 0.35-0.65MPa, temperature by alcohol immersion liquid in vacuumBe 10-15g for being concentrated into solid content in every 100ml concentrate at 50-70 DEG C, obtain alcohol immersionConcentrate;
G, powder process: press cherry water extracting liquid: the weight ratio of alcohol immersion concentrate=1.5-2.5:1Example is mixed, then spraying is dry, obtains cherry powder.
Described root of Dahurain angelica powder is the root of Dahurain angelica powder of gained after being pulverized by the root of Dahurain angelica, or by following method preparationForm:
A, extraction: to adding 2-4 times of weight in the root of Dahurain angelica, by ethyl acetate: 5% aqueous citric acid solutionThe solvent mixing by the part by weight of 3-4:1 extracts 1-2h at 50-75 DEG C, crosses 60-100Mesh sieve, obtains respectively root of Dahurain angelica extract and root of Dahurain angelica slag;
B, separation: extraction root of Dahurain angelica extract is put into tank, treat that it is cooled to normal temperature and standing dividingAfter layer, collect ethyl acetate layer liquid;
The contracting of C, ethyl acetate layer dope: by ethyl acetate layer liquid vacuum be 0.3-0.45MPa,Temperature is that at 35-50 DEG C, to be concentrated into solid content in every 100ml liquid be 6-10g, obtains acetic acid secondEster layer concentrate;
D, water extraction: to the clear water that adds 1.5-3 times of weight in root of Dahurain angelica slag, boil and extract 0.5-1.5h,Cross 100-140 mesh sieve, obtain root of Dahurain angelica pulp water extract;
E, root of Dahurain angelica pulp water extract concentrate: be 0.6-0.8MPa, temperature by root of Dahurain angelica pulp water extract in vacuumDegree is concentrated into the 1/4-1/2 of original volume at being 60-80 DEG C, obtain root of Dahurain angelica slag water extracting liquid;
F, powder process: press ethyl acetate layer concentrate: the weight ratio of root of Dahurain angelica slag water extracting liquid=2-3:1Example is mixed, then spraying is dry, obtains root of Dahurain angelica powder.
Described radix cyathulae powder is the radix cyathulae powder of gained after being pulverized by radix cyathulae, or by following sideMethod is prepared from:
A, pulverizing: radix cyathulae is processed into 30-40 object radix cyathulae powder;
B, alcohol extracting: edible to what to add 1-2 times of weight, volumetric concentration in radix cyathulae powder be 70-90%Ethanol, stirs evenly, and being dipped at normal temperatures and pressures solid content in every 100ml solution is 2.5-4.5g,Cross 100-140 mesh sieve, obtain radix cyathulae alcohol immersion liquid;
C, powder process: be 0.45-0.6MPa at 40-55 DEG C, vacuum by radix cyathulae alcohol immersion liquidUnder be concentrated into the 1/5-1/3 of original volume, then spraying is dry,, obtain radix cyathulae powder.
Described kudzu-vine root powder is the kudzu-vine root powder of gained after being pulverized by the root of kudzu vine, or by following method preparationForm:
A, washing: the root of kudzu vine is dropped in the water of 2-3 times of weight, boil and extract 25-40min, cross 60-100Mesh sieve, obtains respectively root of kudzu vine water extraction liquid and root of kudzu vine slag;
B, alcohol extracting: to dropping into the edible second that 2-3 times of weight, volumetric concentration are 75-85% in root of kudzu vine slagAlcohol, refluxing extraction 30-45min, filters, and obtains root of kudzu vine slag ethanol extract;
C, root of kudzu vine water extraction liquid concentrate: be 0.3-0.45MPa, temperature by root of kudzu vine water extraction liquid in vacuumBe 4-8g for being concentrated into solid content in every 100ml solution at 60-75 DEG C, obtain root of kudzu vine water extraction concentratedLiquid;
D, root of kudzu vine water extraction cream powdering: by spray-dried root of kudzu vine water extracting liquid, obtain water extraction kudzu-vine root powder;
E, root of kudzu vine slag ethanol extract concentrate: by root of kudzu vine slag ethanol extract in vacuum be0.4-0.6MPa, temperature are that at 40-50 DEG C, to be concentrated into ethanol volumetric concentration be 40-50%, obtain root of kudzu vine slagAlcohol extract concentrate, then add the acid oxygen that accounts for root of kudzu vine slag alcohol extract concentrate weight 10-15%Change aluminium, stir 15-20min, filter, obtain root of kudzu vine slag alcohol extract concentrate;
F, root of kudzu vine slag alcohol extract cream powdering: by spray-dried root of kudzu vine slag alcohol extract concentrate,Obtain alcohol extracting root of kudzu vine ground-slag;
G, mixing: by water extraction kudzu-vine root powder: alcohol extracting root of kudzu vine ground-slag mixes according to the part by weight of 1:5-7,Cross 80-120 mesh sieve, obtain kudzu-vine root powder.
Described bark of ash powder is the bark of ash powder of gained after being pulverized by bark of ash, or by by weight followingMaterial mix:
Gentianol 24-40 bark of ash erythricine 50-65 bark of ash kuh-seng phenol 2-5.
The technical scheme of its optimization is to be mixed by following raw material by weight:
Tea polysaccharide 55 cherry powder 10 bark of ash powder 6
Tea seed extract 4 root of Dahurain angelica powder 4 kudzu-vine root powder 15
Radix cyathulae powder 6;
Tea seed extract used is by mixing by following material by weight:
Unrighted acid 63 squalene 35 Tea Polyphenols 2;
Bark of ash powder used is to be mixed by following material by weight:
Gentianol 40 bark of ash erythricine 55 bark of ash kuh-seng phenol 5.
Described tea polysaccharide is (to comprise the camellia oil or the mountain that are processed by camellia seed by tealeaves or tea seedThe tea dregs of rice) or other plant or animal in extract, especially produced with Anhua County, Hunan the black tea that black tea extractsPolysaccharide is for well.
The Chinese medicine composition for the treatment of goat of the present invention, can be made into tablet, pill, powder, sugarThe preparations such as slurry agent, capsule, pill, granule.
The traditional Chinese medical science thinks, gout is due to the damp and hot heresy that is affected by the cold, and causes QI-blood circulation not smooth, channels and collaterals numbnessResistance; Or phlegm-turbidity and blood stasis blood, hinder in channel tunnel, go deep into joint muscle arteries and veins and form. Controlling should be warming channel and expelling cold, and dehumidifying is logicalNetwork, heat-clearing dredging collateral, dissipating phlegm and removing blood stasis, tonifying spleen and kidney all methods.
The Chinese medicine composition for the treatment of goat of the present invention, adopt tea polysaccharide, cherry powder, bark of ash powder,Tea seed extract (comprising unrighted acid, squalene and Tea Polyphenols), root of Dahurain angelica powder, kudzu-vine root powderWith radix cyathulae powder as raw material. Tea polysaccharide (TeaPolysaccharide) is that a kind of similar glossy ganoderma is manySugar and panaxan's macromolecular compound (molecular weight: 40,000-100,000), comprise glucose, IUncle sugar, ribose, galactolipin etc., have the effects such as hypoglycemic, reducing blood lipid, anti-freezing, preventing thrombosis shape,Can improve QI-blood circulation, prevent phlegm-turbidity and blood stasis blood, and in protection blood phase with strengthen that human body is non-specific exempts fromAll there is positive effect the aspects such as epidemic disease ability. Cherry (PrunuspseudocerasusLindl.) propertyWarm, have the merit of tonifying middle-Jiao and Qi concurrently, can dispel rheumatism, can reduce the risk of gout outbreak. Bark of ash(Gentianamacrophylla) can wines used as antirheumatic, clearing away damp-heat, stopping numbness pain, cure mainly rheumatalgia pain,The diseases such as hectic fever hectic fever due to yin. The root of Dahurain angelica [Angelicadahurica(Fisch.exHoffm.) Benth.etHook.f. or Angelicadahurica(Fisch.exHoffm.) Benth.etHook.f.Var.formosana(Boiss.) ShanetYuan] there is inducing sweat loose cold, wind-expelling pain-stopping, eliminating dampnessStop the effects such as band, detumescence and apocenosis. The root of kudzu vine (Puerarialobata) taste cool in nature is sweet pungent, has and induces sweatBring down a fever, promote the production of body fluid, the several functions such as promoting eruption, the positive antidiarrheal of liter, can control fever caused by exogenous pathogens headache, hypertension,Neck pain, thirsty, quench one's thirst, measles without adequate eruption, heat rash, the various diseases such as have loose bowels. Radix cyathulae (RadixCyathulae) can stimulate the menstrual flow by the stasis of blood, easing joint movement. Squalene (chemistry in its tea seed extractName is called 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosa carbon, six alkene) haveImprove superoxide dismutase (SOD) activity in body, enhancing body immunity, anti-ageing, anti-tiredThe different physiological roles such as labor, contribute to treat the illnesss such as rheumatoid arthritis; Tea Polyphenols (TeaPolyphenols) can remove strongly harmful free radical, blocking-up lipid peroxidation process, improves peopleThe activity of body endoenzyme, thus play effect of anti-sudden change; Unrighted acid has maintenance cell membraneRelatively mobility, to ensure the normal physiological function of cell, make cholesterol esterification, reduce courage in bloodSterol and triglycerides, reduce blood viscosity, improve the effects such as blood microcirculation. Therefore, thisThe Chinese medicine composition of bright treatment goat, has heat-clearing dredging collateral, swelling and pain relieving, dispels rheumatism, clearlyDamp and hot, stopping numbness pain, by the stasis of blood stimulate the menstrual flow, easing joint movement, strengthen the effects such as body immunity, therefore can controlTreat multiple gout.
The Chinese medicine composition for the treatment of goat of the present invention, selects the different state of an illness, case history, age, propertyOther patient, from being in hospital and internal clinic selection goat case 50 examples, carried out clinical trial.
One, diagnostic criteria
(i), Western medicine diagnose standard: the standard of formulating for 1997 with reference to American Rheumatism Association:
1. acute arthritis is shown effect more than 1 time and was reached a climax in 24 hours; 2. acute inflammation officeBe limited to indivedual joints; 3. whole joint is kermesinus; 4. the 1st articulationes metatarsophalangeae swells and ache; 5. the one-sided sole of the foot closesJoint acute inflammation; 6. there is the tophus of suspicious confirmation; 7. hyperuricemia; 8. asymmetry is closedJoint swelling; 9. outbreak can stop voluntarily.
At least possess wherein 4, and get rid of secondary gout, can be diagnosed as primary acute gout.
(ii), tcm diagnosis standard: tcm diagnosis is bi Zheng, and dialectical genus damp-heat arthralgia resistance is demonstrate,proved, and disease is seen jointRed and swollen heat pain, limitation of activity, occur together hot, thirsty, sweat is many, dim complexion (taking sallow as many),Urine Huang, tongue fur Huang, slippery and rapid pulse etc.
Two, physical data
Meet observation case totally 50 examples of diagnosis and inclusive criteria, wherein male 32 examples, female's 18 examples,32～45 years old age, average 36 years old; The course of disease 2～5 years, average out to 3 years.
Three, exclusion standard
1. age<18 year old or>65 years old, the gestational period or women breast-feeding their children, allergic constitution and to this medicine mistakeQuick person; 2. merge the serious primary disease such as the cerebrovascular, cardiovascular, liver, kidney and hemopoietic system, essenceGod patient; 3. late period arthritis severe deformity, stiff, disability person; 4. do not meet and include inStandard, not medication in accordance with regulations, or data is not congruent to affect the treatment or security judgement person.
Four, methods for the treatment of
The Chinese medicine composition for the treatment of goat of the present invention for oral administration [weight share by 55 parts of tea polysaccharides,4 parts of 10 parts of cherry powder, 6 parts, bark of ash powder, tea seed extract are (wherein, each in unrighted acidThe percentage by weight of composition is: oleic acid 60, linoleic acid 20, leukotrienes 20), 4 parts, root of Dahurain angelica powder,6 parts of 15 parts of kudzu-vine root powder, radix cyathulae powder mix, and tea seed extract used is by by weightPart 2 parts of 35 parts of 63 parts of unrighted acids, squalenes, Tea Polyphenols mix, the Qin usedMacrophylla powder is 55 parts of 40 parts of gentianols, bark of ash erythricines, the bark of ash kuh-seng phenol 5 by by weightPart mixes], 10 grams/day, divide and take for three times; During patient treatment, withdraw other treatment goutMedicine, forbid high purine diet, maror and drinks etc. Treat observe the curative effect after 2 weeks.
Five, efficacy assessment standard
Reference " new Chinese medicine guideline of clinical investigations " Ministry of Health of the People's Republic of China. Chinese medicineClinical Researches of New Drugs guideline, the 2nd volume (S). Beijing: Ministry of Health of the People's Republic of China prints,1995. ］ curative effect determinate standard in, symptom disappears completely, and joint function recovery is normal, main physics and chemistryIndex for examination is normally clinical cure; Cardinal symptom disappears, and function of joint is recovered substantially, main physics and chemistryIndex for examination normal is effective; Cardinal symptom disappears substantially, main function of joint and main physics and chemistryIndex makes moderate progress as effectively; Each side is all not improved as invalid compared with before treatment.
Six, result for the treatment of
According to statistics, this group case has been treated all kinds of goat patient 50 examples altogether, wherein: cure 36Routine, effective 4 examples, effective 2 examples, invalid 8 examples, total effective rate 84.0%.
Shown by above-mentioned statistics, the Chinese medicine composition for the treatment of goat of the present invention, to gout diseaseDisease has good curative effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further. Explanation is below to exemplifyMode, but protection scope of the present invention is not limited to this.
Embodiment mono-:
The Chinese medicine composition of the treatment goat of the present embodiment is to be mixed by following raw material by weightForm:
Tea polysaccharide 55 cherry powder 10 bark of ash powder 6
Tea seed extract 4 root of Dahurain angelica powder 4 kudzu-vine root powder 15
Radix cyathulae powder 6;
Its preparation method is: above-mentioned raw materials is dropped in trough type mixing machine, add simultaneously and account for raw material gross weightAmount 3-8%(this example employing 5%) food-grade adhesive, limit edged stirs; Then add pure edible secondAlcohol, according on a small quantity, repeatedly add, agglomerating to holding; Then, by its via hole diameter be 10-20 order (thisExample adopts 15 orders) granulator granulate, after granulation, proceed in baking oven 40-60 DEG C of (this example employing50 DEG C) this example of constant pressure and dry 4-7h(employing 5h); Then, will fill with through the capsule of 20000/hThe filling one-tenth capsule of installing, obtain the Chinese medicine composition finished product for the treatment of goat of the present invention, its everyWeight is 0.45g.
This example tea polysaccharide used is produced by Anhua County, Hunan the black tea polysaccharide that black tea extracts.
This example tea seed extract used is to be mixed by following material by weight:
Unrighted acid 63 is squalene 35 Tea Polyphenols 2 not;
(specific to this example: unrighted acid 0.63 × 4=2.52 part, squalene 0.35 × 4=1.4Part, Tea Polyphenols 0.02 × 4=0.08 part; In unrighted acid, the percentage by weight of each composition is:
Oleic acid 60 linoleic acid 20 leukotrienes 20)
This example bark of ash powder used is to be mixed by following material by weight:
Gentianol 40 bark of ash erythricine 55 bark of ash kuh-seng phenol 5;
(specific to this example: gentianol 0.40 × 6=2.4 part, bark of ash erythricine 0.55 × 6=3.3Part, bark of ash kuh-seng phenol 0.05 × 6=0.3 part)
This example cherry powder used is to be prepared from by following method:
A, stoning: get fresh cherry, remove peach kernel, obtain cherry pulp;
B, making beating: cherry pulp is dropped into beater together with accounting for the clear water of cherry pulp weight 40%In, break into 60 object cherry juices;
C, alcohol soak: in cherry juice, add edible ethanol, limit edged stirs, to the volume of ethanolAfter concentration is 70%, be to soak 40min at 60 DEG C in temperature, cross 80 mesh sieves, obtain respectively ethanol and soakBubble liquid and cherry pulp slag;
D, water extraction: to the boiling water that adds 3 times of weight in cherry pulp slag, stir evenly, quiet under normal pressurePut to water temperature and be down to 40 DEG C, cross 120 mesh sieves, obtain falsesour cherry fruit-juice extract;
E, falsesour cherry fruit-juice extract concentrate: be that 0.7MPa, temperature are 70 DEG C by falsesour cherry fruit-juice extract in vacuumUnder to be concentrated into solid content in every 100ml liquid be 6g, obtain cherry water extracting liquid;
F, alcohol immersion liquid concentrate: be that 0.5MPa, temperature are 60 DEG C by alcohol immersion liquid in vacuumUnder to be concentrated into solid content in every 100ml concentrate be 12g, obtain alcohol immersion concentrate;
G, powder process: by cherry water extracting liquid: the part by weight of alcohol immersion concentrate=2:1 carries outMix, then spraying is dry, obtains cherry powder.
This example root of Dahurain angelica powder used is to be prepared from by following method:
A, extraction: to adding 3 times of weight in the root of Dahurain angelica, by ethyl acetate: 5% aqueous citric acid solution is pressedThe solvent that the part by weight of 3:1 mixes extracts 1.5h at 60 DEG C, crosses 80 mesh sieves, respectivelyObtain root of Dahurain angelica extract and root of Dahurain angelica slag;
B, separation: extraction root of Dahurain angelica extract is put into tank, treat that it is cooled to normal temperature and standing dividingAfter layer, collect ethyl acetate layer liquid;
C, the contracting of ethyl acetate layer dope: be that 0.4MPa, temperature are in vacuum by ethyl acetate layer liquidAt 40 DEG C, being concentrated into solid content in every 100ml liquid is 8g, obtains ethyl acetate layer concentrate;
D, water extraction: to the clear water that adds 2 times of weight in root of Dahurain angelica slag, boil and extract 1h, cross 120 ordersSieve, obtains root of Dahurain angelica pulp water extract;
E, root of Dahurain angelica pulp water extract concentrate: be that 0.7MPa, temperature are by root of Dahurain angelica pulp water extract in vacuumAt 70 DEG C, be concentrated into 1/3 of original volume, obtain root of Dahurain angelica slag water extracting liquid;
F, powder process: press ethyl acetate layer concentrate: the weight ratio of root of Dahurain angelica slag water extracting liquid=2.5:1Example is mixed, then spraying is dry, obtains root of Dahurain angelica powder.
This example radix cyathulae powder used is to be prepared from by following method:
A, pulverizing: radix cyathulae is processed into 35 object radix cyathulae powder;
B, alcohol extracting: in radix cyathulae powder, add the edible second that 1.5 times of weight, volumetric concentration are 80%Alcohol, stirs evenly, and being dipped at normal temperatures and pressures solid content in every 100ml solution is 3g, crosses 120 ordersSieve, obtains radix cyathulae alcohol immersion liquid;
C, powder process: be to be concentrated under 0.55MPa at 50 DEG C, vacuum by radix cyathulae alcohol immersion liquid1/4 of original volume, then spraying is dry, obtains radix cyathulae powder.
This example kudzu-vine root powder used is to be prepared from by following method:
A, washing: the root of kudzu vine is dropped in the water of 2.5 times of weight, boil and extract 30min, cross 80 ordersSieve, obtains respectively root of kudzu vine water extraction liquid and root of kudzu vine slag;
B, alcohol extracting: to dropping into the edible ethanol that 2.5 times of weight, volumetric concentration are 80% in root of kudzu vine slag,Refluxing extraction 40min, filters, and obtains root of kudzu vine slag ethanol extract;
C, root of kudzu vine water extraction liquid concentrate: be that 0.4MPa, temperature are 70 DEG C by root of kudzu vine water extraction liquid in vacuumUnder to be concentrated into solid content in every 100ml solution be 6g, obtain root of kudzu vine water extracting liquid;
D, root of kudzu vine water extraction cream powdering: by spray-dried root of kudzu vine water extracting liquid, obtain water extraction kudzu-vine root powder;
E, root of kudzu vine slag ethanol extract are concentrated: by root of kudzu vine slag ethanol extract vacuum be 0.5MPa,Temperature is that at 45 DEG C, to be concentrated into ethanol volumetric concentration be 45%, obtains root of kudzu vine slag alcohol extract concentrate, thenAdd the acidic alumina that accounts for root of kudzu vine slag alcohol extract concentrate weight 12%, stir 18min, filter,Obtain root of kudzu vine slag alcohol extract concentrate;
F, root of kudzu vine slag alcohol extract cream powdering: by spray-dried root of kudzu vine slag alcohol extract concentrate,Obtain alcohol extracting root of kudzu vine ground-slag;
G, mixing: by water extraction kudzu-vine root powder: alcohol extracting root of kudzu vine ground-slag mixes according to the part by weight of 1:6,Cross 100 mesh sieves, obtain kudzu-vine root powder.
Embodiment bis-:
The Chinese medicine composition of the treatment goat of the present embodiment is to be mixed by following raw material by weightForm:
Tea polysaccharide 50 cherry powder 15 bark of ash powder 7
Tea seed extract 3 root of Dahurain angelica powder 5 kudzu-vine root powder 15
Radix cyathulae powder 5;
(specific to this example: unrighted acid 0.65 × 3=1.95 part, squalene 0.32 × 3=0.96Part, Tea Polyphenols 0.03 × 3=0.09 part; In unrighted acid, the percentage by weight of each composition is:
Oleic acid 70 linoleic acid 15 leukotrienes 15)
This example bark of ash powder used is to be mixed by following material by weight:
Gentianol 40 bark of ash erythricine 55 bark of ash kuh-seng phenol 5;
(specific to this example: gentianol 0.45 × 7=3.15 part, bark of ash erythricine 0.50 × 7=3.5Part, bark of ash kuh-seng phenol 0.05 × 7=0.35 part)
Its preparation method is: above-mentioned raw materials is dropped in trough type mixing machine, add simultaneously and account for raw material gross weightAmount 10-16%(this example employing 12%) food-grade adhesive, limit edged stirs; Then add pure edibleEthanol, according on a small quantity, repeatedly add, agglomerating to holding; Then be, 10-20 by its via hole diameterThe granulator of order (this example adopts 15 orders) is granulated, and proceeds in baking oven at 40-60 DEG C of (this after granulationExample adopts 50 DEG C) this example of constant pressure and dry 4-7h(employing 5h); Then, will be through 40000/h'sThe processing of tablet tablet press machine, obtain the Chinese medicine composition finished product for the treatment of goat of the present invention, its everyWeight is 0.65g.
Other is identical with embodiment mono-.
The Chinese medicine composition for the treatment of goat of the present invention, is used for the treatment of goat, is applicable to all ages and classesTake with the goat patient of sex.
Claims (6)
1. treat a Chinese medicine composition for goat, it is characterized in that by following by weightRaw material mixes:
Tea polysaccharide 40-55 cherry powder 10-15 bark of ash powder 5-10
Tea seed extract 3-6 root of Dahurain angelica powder 4-6 kudzu-vine root powder 10-15
Radix cyathulae powder 3-8;
Described tea seed extract is to be mixed by following material by weight:
Unrighted acid 50-70 squalene 25-40 Tea Polyphenols 1.5-3.
2. the Chinese medicine composition for the treatment of according to claim 1 goat, is characterized in that, instituteThe cherry powder of stating is to be prepared from by following method:
A, stoning: get fresh cherry, remove peach kernel, obtain cherry pulp;
B, making beating: cherry pulp is dropped into making beating together with accounting for the clear water of cherry pulp weight 30-50%In machine, break into 40-80 object cherry juice;
C, alcohol soak: in cherry juice, add edible ethanol, limit edged stirs, to the volume of ethanolAfter concentration is 60-80%, be to soak 30-45min at 45-70 DEG C in temperature, cross 60-100 mesh sieve,Obtain respectively alcohol immersion liquid and cherry pulp slag;
D, water extraction: to the boiling water that adds 2-3 times of weight in cherry pulp slag, stir evenly, under normal pressureLeave standstill to water temperature and be down to 30-45 DEG C, cross 100-140 mesh sieve, obtain falsesour cherry fruit-juice extract;
E, falsesour cherry fruit-juice extract concentrate: be that 0.6-0.8MPa, temperature are by falsesour cherry fruit-juice extract in vacuumAt 60-80 DEG C, being concentrated into solid content in every 100mL liquid is 5-8g, obtains cherry water extracting liquid;
F, alcohol immersion liquid concentrate: be 0.35-0.65MPa, temperature by alcohol immersion liquid in vacuumBe 10-15g for being concentrated into solid content in every 100mL concentrate at 50-70 DEG C, obtain alcohol immersionConcentrate;
G, powder process: press cherry water extracting liquid: the weight ratio of alcohol immersion concentrate=1.5-2.5:1Example is mixed, then spraying is dry, obtains cherry powder.
3. the Chinese medicine composition for the treatment of according to claim 1 goat, is characterized in that, instituteThe root of Dahurain angelica powder of stating is to be prepared from by following method:
A, extraction: to adding 2-4 times of weight in the root of Dahurain angelica, by ethyl acetate: 5% aqueous citric acid solutionThe solvent mixing by the part by weight of 3-4:1 extracts 1-2h at 50-75 DEG C, crosses 60-100Mesh sieve, obtains respectively root of Dahurain angelica extract and root of Dahurain angelica slag;
B, separation: extraction root of Dahurain angelica extract is put into tank, treat that it is cooled to normal temperature and standing dividingAfter layer, collect ethyl acetate layer liquid;
The contracting of C, ethyl acetate layer dope: by ethyl acetate layer liquid vacuum be 0.3-0.45MPa,Temperature is that at 35-50 DEG C, to be concentrated into solid content in every 100mL liquid be 6-10g, obtains acetic acid secondEster layer concentrate;
D, water extraction: to the clear water that adds 1.5-3 times of weight in root of Dahurain angelica slag, boil and extract 0.5-1.5h,Cross 100-140 mesh sieve, obtain root of Dahurain angelica pulp water extract;
E, root of Dahurain angelica pulp water extract concentrate: be 0.6-0.8MPa, temperature by root of Dahurain angelica pulp water extract in vacuumDegree is concentrated into the 1/4-1/2 of original volume at being 60-80 DEG C, obtain root of Dahurain angelica slag water extracting liquid;
F, powder process: press ethyl acetate layer concentrate: the weight ratio of root of Dahurain angelica slag water extracting liquid=2-3:1Example is mixed, then spraying is dry, obtains root of Dahurain angelica powder.
4. the Chinese medicine composition for the treatment of according to claim 1 goat, is characterized in that, instituteThe radix cyathulae powder of stating is to be prepared from by following method:
A, pulverizing: radix cyathulae is processed into 30-40 object radix cyathulae powder;
B, alcohol extracting: edible to what to add 1-2 times of weight, volumetric concentration in radix cyathulae powder be 70-90%Ethanol, stirs evenly, and being dipped at normal temperatures and pressures solid content in every 100mL solution is 2.5-4.5g,Cross 100-140 mesh sieve, obtain radix cyathulae alcohol immersion liquid;
C, powder process: be 0.45-0.6MPa at 40-55 DEG C, vacuum by radix cyathulae alcohol immersion liquidUnder be concentrated into the 1/5-1/3 of original volume, then spraying is dry, obtains radix cyathulae powder.
5. the Chinese medicine composition for the treatment of according to claim 1 goat, is characterized in that, instituteThe kudzu-vine root powder of stating is to be prepared from by following method:
A, washing: the root of kudzu vine is dropped in the water of 2-3 times of weight, boil and extract 25-40min, cross 60-100Mesh sieve, obtains respectively root of kudzu vine water extraction liquid and root of kudzu vine slag;
B, alcohol extracting: to dropping into the edible second that 2-3 times of weight, volumetric concentration are 75-85% in root of kudzu vine slagAlcohol, refluxing extraction 30-45min, filters, and obtains root of kudzu vine slag ethanol extract;
C, root of kudzu vine water extraction liquid concentrate: be 0.3-0.45MPa, temperature by root of kudzu vine water extraction liquid in vacuumBe 4-8g for being concentrated into solid content in every 100mL solution at 60-75 DEG C, obtain root of kudzu vine water extraction concentratedLiquid;
D, root of kudzu vine water extraction cream powdering: by spray-dried root of kudzu vine water extracting liquid, obtain water extraction kudzu-vine root powder;
E, root of kudzu vine slag ethanol extract concentrate: by root of kudzu vine slag ethanol extract in vacuum be0.4-0.6MPa, temperature are that at 40-50 DEG C, to be concentrated into ethanol volumetric concentration be 40-50%, obtain root of kudzu vine slagAlcohol extract concentrate, then add the acid oxygen that accounts for root of kudzu vine slag alcohol extract concentrate weight 10-15%Change aluminium, stir 15-20min, filter, obtain root of kudzu vine slag alcohol extract concentrate;
F, root of kudzu vine slag alcohol extract cream powdering: by spray-dried root of kudzu vine slag alcohol extract concentrate,Obtain alcohol extracting root of kudzu vine ground-slag;
G, mixing: by water extraction kudzu-vine root powder: alcohol extracting root of kudzu vine ground-slag mixes according to the part by weight of 1:5-7,Cross 80-120 mesh sieve, obtain kudzu-vine root powder.
6. the Chinese medicine composition for the treatment of according to claim 1 goat, is characterized in that, instituteThe bark of ash powder of stating is to be mixed by following material by weight:
Gentianol 24-40 bark of ash erythricine 50-65 bark of ash kuh-seng phenol 2-5.
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| CN101703708A (en) * | 2009-11-10 | 2010-05-12 | 卢速江 | Chinese medicinal preparation for treating rheumatoid arthritis and gout, and preparation method thereof |
| CN102670879A (en) * | 2012-06-01 | 2012-09-19 | 湖南省回春堂药业有限公司 | Prescriptions for preventing and treating gout and manufacturing method thereof |
| CN103053715A (en) * | 2011-10-22 | 2013-04-24 | 杨煜炜 | Acid tea and preparation method thereof |
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| CN101703708A (en) * | 2009-11-10 | 2010-05-12 | 卢速江 | Chinese medicinal preparation for treating rheumatoid arthritis and gout, and preparation method thereof |
| CN103053715A (en) * | 2011-10-22 | 2013-04-24 | 杨煜炜 | Acid tea and preparation method thereof |
| CN102670879A (en) * | 2012-06-01 | 2012-09-19 | 湖南省回春堂药业有限公司 | Prescriptions for preventing and treating gout and manufacturing method thereof |
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