CN1850160A - Qidantongmai Tablet, and its preparing process - Google Patents
Qidantongmai Tablet, and its preparing process Download PDFInfo
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- CN1850160A CN1850160A CN 200610041900 CN200610041900A CN1850160A CN 1850160 A CN1850160 A CN 1850160A CN 200610041900 CN200610041900 CN 200610041900 CN 200610041900 A CN200610041900 A CN 200610041900A CN 1850160 A CN1850160 A CN 1850160A
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Abstract
The present invention provides a Chinese medicine Qidan Tongmai tablet for effectively curing the diseases of coronary heart disease and angina pectoris, etc. It is made up by using 5 Chinese medicinal materials of astragalus root, salvia root and others through a certain preparation process. Said invention also provides the concrete steps of said preparation method.
Description
Affiliated technical field
Promote blood circulation sheet and preparation technology thereof of stilbene pellet of the present invention belongs to treatment internal disease pure Chinese medicinal preparation and production and processing method thereof, relates in particular to the oral drugs and the preparation technology thereof of a kind of pure treatment by Chinese herbs thoracic obstruction (angina pectoris) disease.
Background technology
The thoracic obstruction (angina pectoris) is the common ailment of middle-aged and old critical illness, sickness rate, the mortality rate height, condition of illness is the vexed pain of portion in the heart, twinge, angor, the rib distention and fullness, pain over the hypochondrium is born pain between back of the body shoulder blade, pain in the medial sides of both arms, shortness of breath and fatigue, cardiopalmus, spontaneous perspiration, see so that angina pectoris symptom more, how because of the resistance of heart-yang numbness, deficiency of heart-YANG declines and blockage of the cardiac vessels, due to QI-blood circulation is not smooth, its risk factor is a hyperlipemia, hypertension, diabetes and smoking and Bad Eating Habit, the traditional treatment thoracic obstruction (angina pectoris) Chinese formulated products kind is a lot, it is dialectical from qi depression to blood stasis adopting more, based on the vital energy regualting and blood circulation-promoting treatment, ignored that resistance of heart-yang numbness or deficiency of heart-YANG decline and the deficiency in origin and excess in superficiality that causes, the different disease cards that deficiency and excess is staggered, in new drug development, pharmacodynamic experiment has mostly been ignored elasticity in heart pump and the blood, the multi-level experiment of the small thrombosis relation of cardiac function and cardiovascular, numerous treatment thoracic obstruction (angina pectoris) efficacy of new drug is not ideal enough, mix improving constantly with people's living standard, hyperlipidemia, hypertension, diabetics the crowd constantly increase, thoracic obstruction disease crowd also increases thereupon, develops evident in efficacy, the safe and reliable treatment thoracic obstruction (angina pectoris) insufficiency of heart-QI is weary, the new drug of blood stasis arteries and veins resistance disease has wide application market.
Summary of the invention:
The objective of the invention is: the development scientific formulation, select that YAOJING is few, the monarch compatibility is reasonable, synergism is remarkable, oral pure easily again Chinese medicinal tablet, make that each Chinese crude drug effective ingredient is integrated in one in the prescription, consumption is few, the curative effect height, after the patient is oral, can improve the lipid disorders state rapidly, improve body immunity, reach the effect of benefiting QI for activating blood circulation, coronary circulation-promoting pain-relieving, the rapid healing thoracic obstruction (angina pectoris).
In order to realize the foregoing invention purpose, promote blood circulation sheet and technical scheme that preparation technology adopted thereof of stilbene pellet of the present invention is: the stilbene pellet promote blood circulation sheet according to chest paralysis main etiology and pathogenesis, with benefiting QI for activating blood circulation, coronary circulation-promoting pain-relieving is principle of treatment, the crude drug total amount is 858.6 grams in the prescription, be made up of the sweet Radix Astragali 224 grams, Radix Salviae Miltiorrhizae 224 grams, Radix Angelicae Sinensis (processed with wine) 112 grams, Flos Carthami 224 grams, Ramulus Cinnamomi 74.6 grams, adjuvant selects for use starch, magnesium stearate, bag Film coated tablets as binding agent, lubricant and coating material respectively.The promote blood circulation preparation technology of sheet of stilbene pellet is divided into powder process, percolation, decoct, oven dry powder process, granulate, compress tablet coating six road technologies, getting Flos Carthami earlier pulverizes in oven dry below 60 ℃, sieve to such an extent that fine powder 140 gram backs are standby respectively with the residue coarse powder, get the 80% ethanol merceration 4 days that Radix Salviae Miltiorrhizae adds 5 times of amounts again, percolation percolation after-filtration, become reconcentration behind the filtrate employing concentrating under reduced pressure method recovery ethanol extractum and medicinal residues to distinguish standby, get the Radix Astragali at last, Radix Angelicae Sinensis, Ramulus Cinnamomi three flavor medical materials and surplus Flos Carthami coarse powder and Radix Salviae Miltiorrhizae decoction dregs add 10 times of water gagings at every turn and decoct twice, the each decoction 2 hours, merging twice decocting liquid filters, it is that the extractum of 1.30-1.35 is standby that filtrate decompression is condensed into 60 ℃ the time, to dry below 60 ℃ behind Flos Carthami fine powder and the water extracted immersing paste and the alcohol-extracted extract mix homogeneously earlier during preparation, adding fine powder weight 10% starch is mixed thoroughly after being ground into fine powder, add again with an amount of 80% ethanol and make soft material, crossing 16 mesh sieves granulates, oven dry below 60 ℃, granulate, add at last with an amount of magnesium stearate and be pressed into 1000, behind the coating patent medicine.
Chinese medicine thinks that chest paralysis is the not smooth result of blockage of the cardiac vessels, QI-blood circulation, in through the argumentation of " obstruction of heart-QI person; arteries and veins is obstructed " and " hesitant pulse is then pained " is arranged, heart governing blood and vessels, heart arteries and veins are obstructed, common pulse condition is puckery late, the blood stasis of blood stagnates, so dim complexion, the common dark violet petechia that has of body of the tongue, these signs are objective reactions of blockage of the cardiac vessels, treatment should be principle with " dredge its QI and blood, make it reach ".In the stilbene pellet is promoted blood circulation sheet, the Radix Astragali is a monarch drug, function with benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening, cure mainly the card of internal injury overstrain, the insufficiency of the spleen deficiency of the lung, edema arthralgia due to stagnation of blood and all Qi and blood deficiencies, water soluble ingredient all can be able to make peripheral red blood cells and hemoglobin increase to the anemia patient in its decoct, and improve platelet and leukocyte, and can increase reticulocyte counts and bone marrow nucleated cell number, help cardiac muscle and other histiocytic metabolism; Radix Salviae Miltiorrhizae is a ministerial drug, has blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, nourishing blood to tranquillize the mind, the function of removing heat from blood eliminating carbuncle, cure mainly trusted subordinate's pain, the carbuncle abdominal mass is gathered, pyretic arthralgia swells and ache, heat is gone into nutrient blood, dysphoria, vexed cardiopalmus, in its ethanol extract in contained TANSHINONES and the decoct water soluble ingredient can promote that all coronary flow obviously increases, coronary resistance obviously descends, and can alleviate the degree of injury of myocardial ischemia, has the effect that prevents myocardial infarction, not only can increase the velocity of blood flow of patients with coronary heart disease, and can increase whole blood and erythrocyte content, can also reduce the synthetic lipotropism electrophoretic mobility of protein that reaches of cell inner cholesterol obviously slows down, thereby has the atherosclerotic effect of improvement, accelerate to recover lipid disorders, effectively treat coronary heart disease and angina pectoris symptom; Radix Angelicae Sinensis, Flos Carthami are all adjuvant drug, Radix Angelicae Sinensis have enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, the function of moisturizing laxation, cure mainly all cards of blood deficiency, contained Wei, Ah acid not only had significant reduction platelet aggregation and anti thrombotic action, significant resistance liver synthetic cholesterol and the injury-free effect of protection tunica intima are arranged again, and the effect that antioxidation is arranged and remove free radical, can produce antiatherogenic effect; Flos Carthami has the function of promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing, cure mainly obstruction of qi in the chest and cardialgia, the carbuncle abdominal mass is gathered, by stagnant blood in the abdomen, its decoct has slight excited heart, reduces the effect of coronary resistance, increase coronary flow and myocardial nutrition blood flow, improve the supply-demand relationship of ischemic myocardium oxygen, myocardial ischemia and myocardial infarction or arrhythmia are had in various degree antagonism; Messenger drug Ramulus Cinnamomi has the function of expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI, cure mainly exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, carbuncle abdominal mass caking, the thoracic obstruction, cardiopalmus, contained cinnamic aldehyde has calmness, analgesia, refrigeration function in the Ramulus Cinnamomi, its decoct can blood vessel dilating, impel the myocardial nutrition blood flow to increase, and cardiovascular disease is all had therapeutical effect.The stilbene pellet tablet recipe science of promoting blood circulation, the monarch compatibility is reasonable, modern Chinese medicine research has confirmed each effective ingredient cooperative compensating of many medicines, effect with benefiting QI for activating blood circulation, coronary circulation-promoting pain-relieving, and all medicines all have the body immunity of raising and anti-inflammatory analgesic effect simultaneously, can improve all card lipid disorders of the thoracic obstruction significantly, effectively treat the thoracic obstruction (angina pectoris).The stilbene pellet is promoted blood circulation sheet only by processing powder medicine and extractum preparation tablet, and its preparation technology's method is easy, low production cost.
The stilbene pellet sheet of promoting blood circulation cures mainly relevant Pharmacodynamic test of active extract with function and confirms in preclinical study: promote blood circulation sheet benefiting QI for activating blood circulation and coronary circulation-promoting pain-relieving effect of stilbene pellet is remarkable, treatment coronary heart disease, allevating angina pectoris, the consumption that improves abnormal electrocardiographic pattern, the cardinal symptom of alleviating the thoracic obstruction, blood viscosity lowering, nitroglycerin and nitroglycerin stop be better than similar traditional medicament aspect the lapse rate curative effect; Recommend clinical adult's medication every day 3 times, each oral 4, about 3.5 grams of day dosage.
The invention has the beneficial effects as follows: prescription thinking novelty, the prescription YAOJING is practiced, monarch compatibility science, preparation technology is easy, and low production cost is by the effective ingredient cooperative compensating, can bring into play the effect of benefiting QI for activating blood circulation, coronary circulation-promoting pain-relieving, treat the thoracic obstruction (angina pectoris) effectively.
Specific embodiments
1, raw material is standby:
The stilbene pellet sheet of promoting blood circulation is made by five tastes Chinese herbal medicine, the wherein sweet Radix Astragali 224 grams, Radix Salviae Miltiorrhizae 224 grams, Radix Angelicae Sinensis (processed with wine) 112 grams, Flos Carthami 224 grams, Ramulus Cinnamomi 74.6 grams, and the well sifted weighing is standby respectively by existing tcm and herbal slice standard before the preparation; The processing stilbene pellet sheet adjuvant of promoting blood circulation is binding agent, lubricant and coating material, and wherein standby appropriate amount of starch is as binding agent, standby an amount of magnesium stearate as tabletting with lubricator, standby an amount of 80% ethanol is as lixiviate and regulate soft material; Standby an amount of bag Film coated tablets is as the tablet coating material.
2, the stilbene pellet sheet preparation technology that promotes blood circulation
1. get Flos Carthami and pulverize in oven dry below 60 ℃, elder generation's sieve gets 140 gram fine powders and the surplus coarse powder difference of institute is standby.
2. get the 80% ethanol merceration 4 days that Radix Salviae Miltiorrhizae adds 5 times of amounts, through the percolation percolation, filter the back adopt filtrate the concentrating under reduced pressure method to reclaim ethanol after reconcentration become extractum standby with the medicinal residues difference.
3. get the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi and standby Flos Carthami coarse powder, Radix Salviae Miltiorrhizae decoction dregs and add 10 times of water gagings at every turn and decoct twice, each 2 hours, merges 2 decocting liquids filtrations, relative density was that the extractum of 1.30-1.35 is standby when filtrate decompression was condensed into 60 ℃.
4. standby Flos Carthami fine powder and two kinds of standby extractum mix homogeneously, after 60 ℃ oven dry is pulverized down, cross 100 mesh sieves and become mixing fine powders standby.
5. an amount of 80% ethanol of reuse is made soft material after adding its weight 10% starch mixing in mixing fine powders, crosses 16 mesh sieves and granulates, the material that granulates of oven dry, granulate below 60 ℃.
6. get bulk goods at last and add an amount of magnesium stearate and be pressed into 1000, reuse bag Film coated tablets coating promptly gets the stilbene pellet sheet of promoting blood circulation, and every nearly weighs 0.3 gram.
Claims (2)
1, a kind of stilbene pellet sheet of promoting blood circulation is characterized in that the crude drug total amount is 858.6 grams, is made up of the sweet Radix Astragali 224 grams, Radix Salviae Miltiorrhizae 224 grams, Radix Angelicae Sinensis (processed with wine) 112 grams, Flos Carthami 224 grams, Ramulus Cinnamomi 74.6 grams.
2, the stilbene pellet preparation technology of sheet that promotes blood circulation according to claim 1, it is characterized in that: get Flos Carthami earlier and pulverize in oven dry below 60 ℃, sieve to such an extent that fine powder 140 gram backs are standby respectively with the residue coarse powder, get the 80% ethanol merceration 4 days that Radix Salviae Miltiorrhizae adds 5 times of amounts again, percolation percolation after-filtration, become reconcentration behind the filtrate employing concentrating under reduced pressure method recovery ethanol extractum and medicinal residues to distinguish standby, get the Radix Astragali at last, Radix Angelicae Sinensis, Ramulus Cinnamomi three flavor medical materials and surplus Flos Carthami coarse powder and Radix Salviae Miltiorrhizae decoction dregs add 10 times of water gagings at every turn and decoct twice, the each decoction 2 hours, merging twice decocting liquid filters, it is that the extractum of 1.30-1.35 is standby that filtrate decompression is condensed into 60 ℃ the time, to dry below 60 ℃ behind Flos Carthami fine powder and the water extracted immersing paste and the alcohol-extracted extract mix homogeneously earlier during preparation, be ground into the starch that adds fine powder weight 10% behind the fine powder and mix thoroughly, add again with an amount of 80% ethanol and make soft material, cross the granulation of 16 mesh sieves, oven dry below 60 ℃, granulate adds at last with an amount of magnesium stearate and is pressed into 1000, behind the coating patent medicine.
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CN 200610041900 CN1850160A (en) | 2006-03-08 | 2006-03-08 | Qidantongmai Tablet, and its preparing process |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103990087A (en) * | 2014-05-15 | 2014-08-20 | 李丽梅 | Traditional Chinese medicine for treating cardiac arrhythmia and preparation method thereof |
CN111569042A (en) * | 2020-06-28 | 2020-08-25 | 马淑珍 | Traditional Chinese medicine preparation for improving human immunity and preparation method thereof |
CN116077554A (en) * | 2022-11-29 | 2023-05-09 | 神威药业集团有限公司 | Preparation method of Guanxinning composition |
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2006
- 2006-03-08 CN CN 200610041900 patent/CN1850160A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103990087A (en) * | 2014-05-15 | 2014-08-20 | 李丽梅 | Traditional Chinese medicine for treating cardiac arrhythmia and preparation method thereof |
CN111569042A (en) * | 2020-06-28 | 2020-08-25 | 马淑珍 | Traditional Chinese medicine preparation for improving human immunity and preparation method thereof |
CN116077554A (en) * | 2022-11-29 | 2023-05-09 | 神威药业集团有限公司 | Preparation method of Guanxinning composition |
CN116077554B (en) * | 2022-11-29 | 2023-12-26 | 神威药业集团有限公司 | Preparation method of Guanxinning composition |
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