CN110393750A - A kind of antirheumatic drug formula, its pharmaceutical composition and preparation method thereof - Google Patents
A kind of antirheumatic drug formula, its pharmaceutical composition and preparation method thereof Download PDFInfo
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- CN110393750A CN110393750A CN201910511147.XA CN201910511147A CN110393750A CN 110393750 A CN110393750 A CN 110393750A CN 201910511147 A CN201910511147 A CN 201910511147A CN 110393750 A CN110393750 A CN 110393750A
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- antirheumatic drug
- antirheumatic
- radix
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of antirheumatic drug formulas, including following components by weight percent: 37.6 parts of tripterygium hypoglaucum hutcs, 3.8 parts of Chinese ephedra, thin 1.9 parts of good fortune, 6.2 parts of ramulus cinnamomi, 6.2 parts of Radix Angelicae Pubescentis, 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, toast 9.4 parts of RADIX ACONITILATERALIS PREPARATA, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf, 9.4 parts of clovershrub.The invention also discloses a kind of preparation methods of antirheumatic drug compositions, the following steps are included: tripterygium hypoglaucum hutcs are extracted with alcohol reflux, Radix Angelicae Pubescentis, ramulus mori, Rhizoma Atractylodis Macrocephalae, Poria cocos, toast RADIX ACONITILATERALIS PREPARATA, radix glycyrrhizae preparata, falcate dolichos root or leaf, clovershrub, it is extracted with decocting method, depending on taking dissolubility of its effective component in different solvents.The above extract is added to get the Chinese medicine composition of antirheumatic drug is arrived in Chinese ephedra, thin good fortune levigation.Antirheumatic drug provided by the invention is mainly used for wind-cold-dampness arthralgia, the treatment of cold-dampness silting type Chinese medicine numbness disease, including the rheumatism immunological diseases such as rheumatoid arthritis, ankylosing spondylitis, centrum and degeneration of joint, osteoporosis, Sjogren syndrome.And have the characteristics that quick, recurrence rate is low, highly-safe, Small side effects etc. are medicinal and at low cost, it is simple for production.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition-antirheumatic drugs, belong to technical field of traditional Chinese medicines.
Background technique
Rheumatism is that a major class disease is referred to as first, it refers to that, with joint, bone, synovial membrane, muscle, ligament, fascia pain is main
One group of disease of symptom segments minimum more than 100 kinds of diseases.
Chinese medicine rheumatism refers to that chill moisture invades human body, muscle arthrosis numb pain caused by causing qi and blood long journey unsmooth,
Stretch unfavorable or enlargement in area.The cause of disease for once causing rheumatism is simply discussed from this disease, broadly several classes of cause of disease point or less, exempt from
Epidemic disease, infection, heredity, four broad aspect of endocrine, rheumatism common sympton pain, stiff, swelling, fatigue are out of strength.
Rheumatism is to probably belong to autoimmune disease, and so-called be immunized is exclusive reaction, lifts a simple case, you feel
Streptococcus hemolyticus is contaminated, then body can generate a kind of antibody for resisting this bacteriotoxin, this antibody and toxin knot naturally
It closes, forms immune complex, rheumatism is then body under the influence of various factors, causes immunologic function disorder, is produced to autologous tissue
Raw antibody generates physical chemistry and changes, and then to influence Bones and joints connective tissue, stimulation generates excessive inflammatory molecule, causes to close
Inflammation is saved, Bones and joints swelling and pain occurs, disease is a systemic disease in fact in joint.
Clinical manifestation, patient can have Tou Tong ﹑ Fa Re ﹑ Wei Han ﹑ E Feng ﹑ Shen Chong ﹑ little, and just the joint Bu Li ﹑ Suan Tong ﹑ cannot be bent and stretched
Deng.Arthropathy, also with swelling and moving obstacle, in breaking-out and alleviates the alternate chronic course of disease in addition to having pain.Due to patient
Blood circulation it is poor, cause muscle or organize required for nutrition can not be conveyed by blood circulation, cause patient muscle
Lack nutrition and accelerated ageing becomes stiff, serious to will lead to patient muscle and blood vessel die back, some patientss may occur in which joint
Disable and viscera function exhaustion.To life, work is made troubles or even threat to life.
The drug for treating rheumatism includes: the anti-inflammatory analgesic of 1, nonsteroidal: such as Voltarol, Ibumetin Retavd, Luo Suo
Ibuprofen natrium capsule or piece etc., side effect are gastrointestinal tract mucosa stimulation and liver kidney toxic side effect；2, slow-acting drug: Tathagata fluorine rice
Spy, methotrexate (MTX), cyclophosphamide etc. need to take for a long time, and duration of medication will monitor blood routine, liver its main feature is that it is slower to work
The safety indexes such as function, kidney function；3, glucocorticoid: with double action anti-inflammatory and that inhibition is immune, it is chiefly used in rheumatoid
When arthritis active stage or concurrent Multi-system injuries, but there are gastrointestinal mucosa stimulation, caput femoris necrosis, hypertension, hyperglycemia etc.
Adverse reaction；4, biological agent: emerging antirheumatic, advantage are with the work for adjusting immune response, inhibiting immune inflammation
With the disadvantage is that expenses for medicine is higher；
Chinese medicine treatment: treatment rheumatism has unique advantage, may be selected to take traditional Chinese herbal decoction, Chinese patent drug or external application Chinese medicine heat
It applies, importing or even Combined with Acupuncture are treated.Its advantage has: one, effectively, being capable of effective antirheumatic；Two, safety it is without side-effects, to people
Body is not damaged；Three, convenient to take；Four, do not allow easy to recur；Five, there is protective effect to liver.The disadvantage is that: treatment time is long, treatment
Period may be even several years some months or more.
The Chinese patent drug of commercially available existing treatment rheumatism, majority have the shortcomings that component is more, preparation process is complicated.The present invention relates to
And a kind of Chinese medicine composition --- antirheumatic drug has that curative effect really, that prescription component constitutes simple, preparation process simplicity etc. is excellent
Gesture.
Summary of the invention
To solve rheumatism to uncomfortable brought by human body, and overcome the shortcomings of the prior art, the present invention
A kind of Chinese medicine of antirheumatic is provided.
The object of the present invention is to provide a kind of antirheumatic drug formulas, it is characterised in that is grouped by the group of following mass parts
At:
37.6 parts of tripterygium hypoglaucum hutcs, 3.8 parts of Chinese ephedra, thin 1.9 parts of good fortune, 6.2 parts of ramulus cinnamomi, 6.2 parts of Radix Angelicae Pubescentis, 6.2 parts of ramulus mori, life
6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, toast 9.4 parts of RADIX ACONITILATERALIS PREPARATA, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf, 9.4 parts of clovershrub.
Another object of the present invention is to provide a kind of antirheumatic drug formula, the component of preferably following mass parts:
37.6 parts of tripterygium hypoglaucum hutcs, 3.8 parts of Chinese ephedra, thin 1.9 parts of good fortune, 6.2 parts of ramulus cinnamomi, 6.2 parts of Radix Angelicae Pubescentis, 6.2 parts of ramulus mori, life
6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, toast 9.4 parts of RADIX ACONITILATERALIS PREPARATA, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf, 9.4 parts of clovershrub.
Another object of the present invention is to provide a kind of pharmaceutical compositions, it is characterised in that: by antirheumatic drug described above
Formula and pharmaceutically acceptable pharmaceutic adjuvant composition.The pharmaceutic adjuvant such as starch and magnesium stearate etc., by existing skill
Pharmaceutically acceptable any preparation, such as decoction, tablet, capsule, granule preparation is made in conventional method in art.
Another object of the present invention is to provide a kind of preparation methods of aforementioned pharmaceutical compositions: by tripterygium hypoglaucum hutcs
37.6 parts are extracted with alcohol reflux, obtain ethanol extract, by 6.2 parts of ramulus cinnamomi, 6.2 parts of Radix Angelicae Pubescentis, 6.2 parts of ramulus mori, raw Rhizoma Atractylodis Macrocephalae 6.2
Part, 6.2 parts of Poria cocos, toast 9.4 parts of RADIX ACONITILATERALIS PREPARATA, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf, 9.4 parts of clovershrub extracted with decocting method, obtain water
Extract merges two kinds of extracts；1.9 parts of 3.8 parts of Chinese ephedra, thin good fortune levigations are added in the extract after aforementioned merging to get wind resistance
Wet drug extract, and/or the Chinese medicine composition of antirheumatic drug is prepared with pharmaceutically acceptable pharmaceutic adjuvant.
Tripterygium hypoglaucum hutcs effective component is mainly diterpenic lactone, and thunderous rattan element is first-class, is dissolved in ethanol solution
The good of property and the effective components such as ramulus cinnamomi, Poria cocos are mainly polysaccharide, alkaloid etc., solubility is good in water.
It is preferably 1:4,1:6,1:8 that the ethyl alcohol, which proposes the solid-liquid mass ratio proposed with water,.
The alcohol reflux extracts, and extracts three times, 1 hour every time, takes supernatant, merges filtrate three times and is concentrated into 50 DEG C
When relative density be 1.15~1.25 medicinal extract.
The decocting method extracts three times, 1 hour every time, takes supernatant, phase when merging filtrate three times and being concentrated into 50 DEG C
The medicinal extract for being 1.15~1.25 to density.
Another object of the present invention is to provide the preparation methods of aforementioned pharmaceutical compositions different dosage forms, it is characterised in that:
Appropriate amount of starch, magnesium stearate are added in antirheumatic drug compositions obtained above, is made by conventional method in the prior art
Tablet；Wherein, the meter of total amount containing alkaloid in every, must not be less than 1mg.
Appropriate amount of starch, magnesium stearate are added in antirheumatic drug compositions obtained above, by routine in the prior art
Capsule is made in method；Wherein, the meter of total amount containing alkaloid in every capsule must not be less than 1mg.
Appropriate amount of starch, magnesium stearate are added in antirheumatic drug compositions obtained above, by routine in the prior art
Granule is made in method；Wherein, the meter of total amount containing alkaloid in every bag, must not be less than 3mg.
Wherein, tripterygium hypoglaucum hutcs: liver,spleen,kidney is returned to pass through.Effect, dispelling wind and eliminating dampness, promoting blood circulation and hemostasis, relieving rigidity of muscles and knitting bone, solution poisoning
Worm.It cures mainly, rheumatic arthralgia, hemiplegia, hernia pain, dysmenorrhea, menorrhalgia, postpartum abdominal pain, haemophilia, acute infective liver
Inflammation, chronic nephritis, lupus erythematosus, cancerous swelling, injury and bone fracture, osteomyelitis, bone tuberculosis, epididymis tuberculosis, sore, psoriasis, nerve
Dermatitis.
Ramulus cinnamomi: nature and flavor: temperature, it is pungent；It is sweet.Return heart, lung, bladder meridian.Effect, sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi are put down
Spin gas.It cures mainly, is used for anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, arthralgia, phlegm retention, oedema, palpitaition, renal mass.
Poria cocos: nature and flavor: it is sweet in flavor, light, it is mild-natured.Return heart, lung, spleen, kidney channel.Effect, clearing damp and promoting diuresis, invigorating the spleen, calming heart.It cures mainly,
For edema and little urine, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Process RADIX ACONITILATERALIS PREPARATA: nature and flavor: pungent, sweet, big heat；It is toxic.It belongs to the heart, kidney, spleen channel.Function, recuperating depleted yang, mends fire supporing yang dissipate
Cold analgesic.Cure mainly yang depletion collapse, cold weak pulse of limb, deficiency of heart-YANG, chest impediment and cardialgia, cold of insufficiency type vomiting and diarrhea, coldness and pain in the epigastrium, decline of kidney-YANG, sun
Impotence palace cold, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.
Chinese ephedra: nature and flavor: pungent, slight bitter, temperature.Effect: inducing sweat and dispelling exogenous evils are freeinged lung and relieving asthma, inducing diuresis for removing edema.The major functions: chill exterior syndrome,
It is uncomfortable in chest to breath with cough, geomantic omen edema, rheumatic arthralgia, negative subcutaneous ulcer, subcutaneous nodule.The warm-natured inclined profit of Herba ephedrae, pungent scattered perspiration mitigate, and enhance profit
The function of lung cough-relieving, with cough-relieving power victory of freeinging lung and relieving asthma.It is chiefly used in table disease to have solved, asthma and cough.The effect of Chinese ephedra suede mitigates, and is suitable for old
People, child and empty people's anemofrigid cold.Herba ephedrae suede effect more mitigates, suitable for exterior syndrome solved and breath with cough not more old man, child
And physically weak patient.
Thin good fortune: nature and flavor: it is acrid in flavour and warm in nature, it is slightly poisonous.Effect: relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, warming lung and resolving fluid.The major functions: chill
Flu is had a headache, toothache, rheumatic arthralgia, nasosinusitis, lung cold cough.
Radix Angelicae Pubescentis: nature and flavor: acrid flavour, hardship, slightly warm in nature.Effect: dispelling wind and eliminating dampness, arthritis analgesic.The major functions: being used for treating arthralgia due to cold and dampness, waist
Knee pain, few the moon volt wind headache, headache caused by cold and dampness.
Ramulus mori: nature and flavor: mildly bitter flavor, it is mild-natured.Effect: there are wind-damp dispelling, the effect in sharp joint.The major functions: being used for Bi condition, shoulder
Arm, joint pain are numb.
Raw Rhizoma Atractylodis Macrocephalae: nature and flavor: bitter, sweet and warm-natured.Effect: strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect.The major functions: controlling deficient QI of the spleen and stomach, do not think
Diet, burnout lack gas, and empty swollen, diarrhea, phlegm retention, oedema, jaundice, arthritis with fixed pain caused by dampness, difficult urination is dizzy, spontaneous perspiration, and nausea is uneasy.
Radix glycyrrhizae preparata: nature and flavor: it is warm-natured, it is sweet in flavor.Effect: tonifying spleen stomach function regulating, Yiqi and vein recovery.The major functions: arrhythmia cordis, viral cardiac muscle
The various diseases such as scorching pair.
Falcate dolichos root or leaf: nature and flavor: acrid flavour, it is warm-natured.Effect: dispelling wind and removing obstruction in the meridians, analgesic hemostatic.The major functions: it is used for rheumatic arthralgia, bruise damage
Wound, traumatic hemorrhage.
Clovershrub: nature and flavor: it is sweet light, it is cool.Effect: promoting blood circulation, wind-dispelling are managed wet.The major functions: rheumatic arthralgia is controlled, and diarrhea, dysentery, blood
Leaching, internal lesion caused by overexertion hemoptysis.
Each traditional Chinese medicine ingredients of the invention are national corporation of medical herbs commercial product.
The effect and advantage that the present invention has:
Antirheumatic drug provided by the invention is mainly used for wind-cold-dampness arthralgia, the treatment of cold-dampness silting type Chinese medicine numbness disease, including class
The rheumatism immunological diseases such as rheumathritis, ankylosing spondylitis, centrum and degeneration of joint, osteoporosis, Sjogren syndrome.
And have the characteristics that quick, recurrence rate is low, highly-safe, Small side effects etc. are medicinal and at low cost, it is simple for production.
Specific embodiment
Below in conjunction with the embodiment content that the present invention is furture elucidated, but protection scope of the present invention is not limited in this
A little embodiments.
Embodiment 1
(1) solid-liquid mass ratio is 1 ︰ 4, and 37.6 parts of tripterygium hypoglaucum hutcs are extracted three times with alcohol reflux, 1 hour every time, is taken
Supernatant, the medicinal extract that relative density when merging filtrate three times and being concentrated into 50 DEG C is 1.15~1.25.6.2 parts of ramulus cinnamomi, Radix Angelicae Pubescentis
6.2 parts, it is 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, 9.4 parts of RADIX ACONITILATERALIS PREPARATA of toast, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf, big
9.4 parts of red robe is extracted three times with decocting method, 1 hour every time, takes supernatant, opposite when merging filtrate three times and being concentrated into 50 DEG C
The medicinal extract that density is 1.15~1.25.Above-mentioned two medicinal extract merges to obtain extract.More than 3.8 parts of Chinese ephedra, thin 1.9 parts of levigations of good fortune are added
Extract obtains the Chinese medicine composition of antirheumatic drug.
(2) appropriate amount of starch, magnesium stearate are added in said medicine, tablet is made by conventional method in the prior art；
Wherein, the meter of total amount containing alkaloid in every, must not be less than 1mg.
Embodiment 2
(1) it is 1 ︰ 6 by solid-liquid mass ratio, 37.6 parts of tripterygium hypoglaucum hutcs is extracted three times with alcohol reflux, 1 hour every time,
Take supernatant, the medicinal extract that relative density when merging filtrate three times and being concentrated into 50 DEG C is 1.15~1.25.6.2 parts of ramulus cinnamomi, solely
6.2 parts living, 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, 9.4 parts of RADIX ACONITILATERALIS PREPARATA of toast, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf,
9.4 parts of clovershrub is extracted three times with decocting method, 1 hour every time, takes supernatant, phase when merging filtrate three times and being concentrated into 50 DEG C
The medicinal extract for being 1.15~1.25 to density.Above-mentioned two medicinal extract merges to obtain extract.3.8 parts of Chinese ephedra, thin 1.9 parts of levigations of good fortune be added with
Upper extract obtains the Chinese medicine composition of antirheumatic drug.
(2) appropriate amount of starch, magnesium stearate are added in said medicine, tablet is made by conventional method in the prior art；
Wherein, the meter of total amount containing alkaloid in every, must not be less than 1mg.
Embodiment 3
(1) it is 1 ︰ 8 by solid-liquid mass ratio, 37.6 parts of tripterygium hypoglaucum hutcs is extracted three times with alcohol reflux, 1 hour every time,
Take supernatant, the medicinal extract that relative density when merging filtrate three times and being concentrated into 50 DEG C is 1.15~1.25.6.2 parts of ramulus cinnamomi, solely
6.2 parts living, 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, 9.4 parts of RADIX ACONITILATERALIS PREPARATA of toast, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf,
9.4 parts of clovershrub is extracted three times with decocting method, 1 hour every time, takes supernatant, phase when merging filtrate three times and being concentrated into 50 DEG C
The medicinal extract for being 1.15~1.25 to density.Above-mentioned two medicinal extract merges to obtain extract.3.8 parts of Chinese ephedra, thin 1.9 parts of levigations of good fortune be added with
Upper extract obtains the Chinese medicine composition of antirheumatic drug.
(2) appropriate amount of starch, magnesium stearate are added in said medicine, tablet is made by conventional method in the prior art；
Wherein, the meter of total amount containing alkaloid in every, must not be less than 1mg.
Embodiment 4
(1) it is 1 ︰ 4 by solid-liquid mass ratio, 37.6 parts of tripterygium hypoglaucum hutcs is extracted three times with alcohol reflux, 1 hour every time,
Take supernatant, the medicinal extract that relative density when merging filtrate three times and being concentrated into 50 DEG C is 1.15~1.25.6.2 parts of ramulus cinnamomi, solely
6.2 parts living, 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, 9.4 parts of RADIX ACONITILATERALIS PREPARATA of toast, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf,
9.4 parts of clovershrub is extracted three times with decocting method, 1 hour every time, takes supernatant, phase when merging filtrate three times and being concentrated into 50 DEG C
The medicinal extract for being 1.15~1.25 to density.Above-mentioned two medicinal extract merges to obtain extract.3.8 parts of Chinese ephedra, thin 1.9 parts of levigations of good fortune be added with
Upper extract obtains the Chinese medicine composition of antirheumatic drug.
(2) appropriate amount of starch, magnesium stearate are added in said medicine, hard capsule is made by conventional method in the prior art
Agent；Wherein, the meter of total amount containing alkaloid in every capsule must not be less than 1mg.
Embodiment 5
(1) it is 1 ︰ 6 by solid-liquid mass ratio, 37.6 parts of tripterygium hypoglaucum hutcs is extracted three times with alcohol reflux, 1 hour every time,
Take supernatant, the medicinal extract that relative density when merging filtrate three times and being concentrated into 50 DEG C is 1.15~1.25.6.2 parts of ramulus cinnamomi, solely
6.2 parts living, 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, 9.4 parts of RADIX ACONITILATERALIS PREPARATA of toast, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf,
9.4 parts of clovershrub is extracted three times with decocting method, 1 hour every time, takes supernatant, phase when merging filtrate three times and being concentrated into 50 DEG C
The medicinal extract for being 1.15~1.25 to density.Above-mentioned two medicinal extract merges to obtain extract.3.8 parts of Chinese ephedra, thin 1.9 parts of levigations of good fortune be added with
Upper extract obtains the Chinese medicine composition of antirheumatic drug.
(2) appropriate amount of starch, magnesium stearate are added in said medicine, hard capsule is made by conventional method in the prior art
Agent；Wherein, the meter of total amount containing alkaloid in every capsule must not be less than 1mg.
Embodiment 6
(2) it is 1 ︰ 8 by solid-liquid mass ratio, 37.6 parts of tripterygium hypoglaucum hutcs is extracted three times with alcohol reflux, 1 hour every time,
Take supernatant, the medicinal extract that relative density when merging filtrate three times and being concentrated into 50 DEG C is 1.15~1.25.6.2 parts of ramulus cinnamomi, solely
6.2 parts living, 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, 9.4 parts of RADIX ACONITILATERALIS PREPARATA of toast, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf,
9.4 parts of clovershrub is extracted three times with decocting method, 1 hour every time, takes supernatant, phase when merging filtrate three times and being concentrated into 50 DEG C
The medicinal extract for being 1.15~1.25 to density.Above-mentioned two medicinal extract merges to obtain extract.3.8 parts of Chinese ephedra, thin 1.9 parts of levigations of good fortune be added with
Upper extract obtains the Chinese medicine composition of antirheumatic drug.
(2) appropriate amount of starch, magnesium stearate are added in said medicine, hard capsule is made by conventional method in the prior art
Agent；Wherein, the meter of total amount containing alkaloid in every capsule must not be less than 1mg.
Embodiment 7
(1) it is 1 ︰ 4 by solid-liquid mass ratio, 37.6 parts of tripterygium hypoglaucum hutcs is extracted three times with alcohol reflux, 1 hour every time,
Take supernatant, the medicinal extract that relative density when merging filtrate three times and being concentrated into 50 DEG C is 1.15~1.25.6.2 parts of ramulus cinnamomi, solely
6.2 parts living, 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, 9.4 parts of RADIX ACONITILATERALIS PREPARATA of toast, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf,
9.4 parts of clovershrub is extracted three times with decocting method, 1 hour every time, takes supernatant, phase when merging filtrate three times and being concentrated into 50 DEG C
The medicinal extract for being 1.15~1.25 to density.Above-mentioned two medicinal extract merges to obtain extract.More than 3.8 parts yellow, thin good fortune, 1.9 parts of levigations are added
Extract obtains the Chinese medicine composition of antirheumatic drug.
(2) appropriate amount of starch, magnesium stearate are added in said medicine, particle is made by conventional method in the prior art
Agent；Wherein, the meter of total amount containing alkaloid in every bag, must not be less than 3mg.
Embodiment 8
(1) it is 1 ︰ 6 by solid-liquid mass ratio, 37.6 parts of tripterygium hypoglaucum hutcs is extracted three times with alcohol reflux, 1 hour every time,
Take supernatant, the medicinal extract that relative density when merging filtrate three times and being concentrated into 50 DEG C is 1.15~1.25.6.2 parts of ramulus cinnamomi, solely
6.2 parts living, 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, 9.4 parts of RADIX ACONITILATERALIS PREPARATA of toast, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf,
9.4 parts of clovershrub is extracted three times with decocting method, 1 hour every time, takes supernatant, phase when merging filtrate three times and being concentrated into 50 DEG C
The medicinal extract for being 1.15~1.25 to density.Above-mentioned two medicinal extract merges to obtain extract.The thin 1.9 parts of levigations of good fortune of 3.8 parts of Chinese ephedra be added with
Upper extract obtains the Chinese medicine composition of antirheumatic drug.
(2) appropriate amount of starch, magnesium stearate are added in said medicine, particle is made by conventional method in the prior art
Agent；Wherein, the meter of total amount containing alkaloid in every bag, must not be less than 3mg.
Embodiment 9
(1) it is 1 ︰ 8 by solid-liquid mass ratio, 37.6 parts of tripterygium hypoglaucum hutcs is extracted three times with alcohol reflux, 1 hour every time,
Take supernatant, the medicinal extract that relative density when merging filtrate three times and being concentrated into 50 DEG C is 1.15~1.25.6.2 parts of ramulus cinnamomi, solely
6.2 parts living, 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, 9.4 parts of RADIX ACONITILATERALIS PREPARATA of toast, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf,
9.4 parts of clovershrub is extracted three times with decocting method, 1 hour every time, takes supernatant, phase when merging filtrate three times and being concentrated into 50 DEG C
The medicinal extract for being 1.15~1.25 to density.Above-mentioned two medicinal extract merges to obtain extract.The thin 1.9 parts of levigations of good fortune of 3.8 parts of Chinese ephedra be added with
Upper extract obtains the Chinese medicine composition of antirheumatic drug.
(2) appropriate amount of starch, magnesium stearate are added in said medicine, particle is made by conventional method in the prior art
Agent；Wherein, the meter of total amount containing alkaloid in every bag, must not be less than 3mg.
10 pharmacology toxicologic study of embodiment
The pharmacology toxicologic study of the Chinese medicine composition of antirheumatic drug provided by the invention:
Toxicologic study: when the Chinese traditional medicine composition with 20g/kg, obtained in 10g/kg, 5g/kg application embodiment 1-9 to rat
Object, it is continuous to after rats gavaged 90 days, animal general activity, weight, blood hemoglobin, leucocyte, red blood cell, blood platelet,
GPT, GOT, BUN, G are without exception in leukocyte differential count, blood, and there was no significant difference with physiological saline group, and numerical value is normal
Range also has no adverse effects to main organs such as rats'liver, spleen, lung, kidney, intestines, brain, testis, ovaries.
11 pharmacodynamic test of embodiment
The pharmaceutical composition that acquisition is formulated in previous embodiment 1-9 is 2000 dosages, with three times a day, each taking
Tripterygium hypoglaucum hutcs 3.5g, Chinese ephedra 0.35g, thin good fortune 0.17g, ramulus cinnamomi 0.6g, Radix Angelicae Pubescentis 0.6g, ramulus mori 0.6g, raw Rhizoma Atractylodis Macrocephalae 0.6g, Poria cocos
0.6g, toast RADIX ACONITILATERALIS PREPARATA 0.85g, radix glycyrrhizae preparata 0.17g, falcate dolichos root or leaf 0.45g, clovershrub 0.85gFor taking doseCarry out pharmacodynamic test.
Patient it is high certain, female, 71 years old, peasant symptoms include buttocks and lower limb pain, difficulty in walking.Bilateral buttocks occurs blunt before 3 years
Bitterly, and gradually it aggravates, walks lamely sometimes.Before bilateral hip joint, pain is often radiated on the inside of knee joint at the position of pain.It presses
The pharmaceutical composition of antirheumatic drug provided by the invention is 1 ︰ 6 by solid-liquid mass ratio, is added water to cook three times, 1 hour every time, is merged
Supernatant, 200ml takes three times a day, every time, even served 30, and walking situation is clearly better, and lower limb pain mitigates.Continue to take medicine
30 days, hip knee pain symptom was substantially reduced.It is discontinued 7 days, continues medication 30 days, patient's walking is normal.To consolidate drug effect, stop
Medicine 7 days, continue medication 30 days, is discontinued.
Patient's week certain, male 58 years old, there is rheumatoid medical history more than two decades, and once Multiple Hospitalization is treated, and skin occurs in nearly patient in January
Skin changes, pruitus, forms purpura, and that presses is colour-fast.Solid-liquid is pressed by the pharmaceutical composition of antirheumatic drug provided by the invention
Mass ratio is 1 ︰ 6, is added water to cook three times, 1 hour every time, merges supernatant, 200ml takes three times a day, every time, even served 30
Day, skin itching symptom disappears, and purpura significantly reduces.Continue medication 30 days, purpura symptom is substantially reduced.It is discontinued 7 days, continues to take
Medicine 30 days, purpura symptom disappeared substantially.To consolidate drug effect, it is discontinued 7 days, continues medication 30 days, be discontinued.(problem is same as above)
52 years old, shoulder joint dull pain January, there is edema of limbs in nearly one week in patient what certain, male.By wind resistance provided by the invention
The pharmaceutical composition of wet medicine is 1 ︰ 6 by solid-liquid mass ratio, is added water to cook three times, 1 hour every time, and supernatant is merged, three times a day,
Each 200ml takes, and even served 30, and edema of limbs disappears, and feeling of pain mitigates.Continue medication 30 days, feeling of pain disappears substantially.For
Consolidate drug effect, be discontinued 7 days, continue medication 30 days, is discontinued.(problem is same as above)
Patient is from certain, and female, 49 years old, shoulder was carried on the back swelling and pain 15 days.By the pharmaceutical composition of antirheumatic drug provided by the invention
It is 1 ︰ 6 by solid-liquid mass ratio, adds water to cook three times, 1 hour every time, merge supernatant, 200ml takes three times a day, every time, even
It takes 15,5 feeling of pains are substantially reduced.Continue medication 15 days, feeling of pain disappears substantially.To consolidate drug effect, it is discontinued 7 days, continues to take
It medicine 30 days, is discontinued.(problem is same as above)
Patient's Qi, female, 47 years old symptoms include the soreness of waist back ache, left hand metacarpal bone thumb joint expands.By provided by the invention anti-
The pharmaceutical composition of medicine for rheumatism is 1 ︰ 6 by solid-liquid mass ratio, is added water to cook three times, 1 hour every time, merging supernatant, daily three
Secondary, each 200ml takes, and even served 15, feeling of pain is substantially reduced.Continue medication 15 days, feeling of pain disappears substantially.To consolidate medicine
Effect is discontinued 7 days, continues medication 30 days, is discontinued.(problem is same as above)
Patient Xu certain, male, 42 years old symptoms include both hands joint deformity, swelling pain.By the medicine of antirheumatic drug provided by the invention
Compositions are 1 ︰ 6 by solid-liquid mass ratio, are added water to cook three times, 1 hour every time, merge supernatant, three times a day, every time
200ml takes, and even served 30, feeling of pain is substantially reduced.Continue medication 30 days, feeling of pain disappears substantially.It is discontinued 7 days, continues to take
Medicine 30 days, both hands joint deformity situation slightly improved.To consolidate drug effect, continues medication 30 days, be discontinued.(problem is same as above)
Patient Zhang, 39 years old, female symptoms include right Ankle lateral winter fear cold pain 2 years, readme 10 years before once sprain it is right
Ankle-joint by solid-liquid mass ratio is 1 ︰ 6 by the pharmaceutical composition of antirheumatic drug provided by the invention, adds water to cook three times, every time 1
Hour, merge supernatant, 200ml takes three times a day, every time, even served 30, it is substantially reduced to fear cold feeling of pain.Continue medication 30
It, fears cold feeling of pain and disappears substantially.It is discontinued 7 days, continues medication 30 days, fear cold feeling of pain and disappear.To consolidate drug effect, continue to take medicine
It 30 days, is discontinued.(problem is same as above)
The Chinese medicine composition of the antirheumatic drug of the application is according to Yi nationality of Yunnan folk remedy, and in Chinese medicine ancient prescription, (Song is " too
Flat the Bureau of People's Welfare Pharmacies side ") on the basis of, in conjunction with Yunnan folk medicine experience, developed through scientific composition pure natural
Ethnic drug, through over thousands of example clinical verification, which is the good medicine for treating antirheumatic.For treat rheumatoid arthritis,
The rheumatism immunological diseases such as ankylosing spondylitis, centrum and degeneration of joint, osteoporosis, Sjogren syndrome are treatment strong wind
The good medicine of wet class disease.
The Chinese medicine composition of the antirheumatic drug of the application is related to 12 kinds of genuine Chinese medicinal herbs, be all Yunnan easily growth with
The kind of picking.This composition has the advantages that inexpensive, safety, curative effect really, toxic side effect are low, has and develops Chinese Traditional Medicine
Culture and the far reaching significance for spreading Yi nationality, distributed over Yunnan, Sichuan and Guizhou's folk remedy far and wide.The Chinese medicine composition of the antirheumatic drug have quick, recurrence rate is low, safety
The medicinal features such as property height, Small side effects, and it is at low cost, simple for production the advantages that, obtained stable product quality, user
Just, more suitable for clinical application.The Chinese medicine composition of the antirheumatic drug of the application draws up into tablet, capsule or granule, selects for a post
Select quantitative detection of the main ingredient tripterygium hypoglaucum hutcs effective component alkaloid total amount as this preparation.
Claims (11)
1. a kind of antirheumatic drug formula, including following components by weight percent: 37.6 parts of tripterygium hypoglaucum hutcs, 3.8 parts of Chinese ephedra, thin 1.9 parts of good fortune,
6.2 parts of ramulus cinnamomi, 6.2 parts of Radix Angelicae Pubescentis, 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, toast 9.4 parts of RADIX ACONITILATERALIS PREPARATA, radix glycyrrhizae preparata 1.9
Part, 5 parts of falcate dolichos root or leaf, 9.4 parts of clovershrub.
2. a kind of pharmaceutical composition, it is characterised in that: the antirheumatic drug formula as described in claim 1 and pharmaceutically acceptable
Pharmaceutic adjuvant composition.
3. pharmaceutical composition as claimed in claim 2, which is characterized in that dosage form is selected from decoction, capsule, tablet or particle
Agent.
4. the preparation method of pharmaceutical composition as claimed in claim 2: 37.6 parts of tripterygium hypoglaucum hutcs being extracted with alcohol reflux, is obtained
Ethanol extract, by 6.2 parts of ramulus cinnamomi, 6.2 parts of Radix Angelicae Pubescentis, 6.2 parts of ramulus mori, raw 6.2 parts of Rhizoma Atractylodis Macrocephalae, 6.2 parts of Poria cocos, toast RADIX ACONITILATERALIS PREPARATA 9.4
Part, 1.9 parts of radix glycyrrhizae preparata, 5 parts of falcate dolichos root or leaf, 9.4 parts of clovershrub extracted with decocting method, obtain water extract, merge two kinds of extracts；Chinese ephedra
3.8 parts, 1.9 parts of levigations of thin good fortune be added to get antirheumatic extract in the extract after aforementioned merging, and/or with pharmaceutically
The Chinese medicine composition of antirheumatic drug is prepared in acceptable pharmaceutic adjuvant.
5. the preparation method according to claim 4, it is characterised in that: the solid-liquid mass ratio that the ethyl alcohol mentions and water mentions all is
1:4.
6. the preparation method according to claim 4, it is characterised in that: it is 1 that the ethyl alcohol, which proposes the solid-liquid mass ratio proposed with water:
6。
7. the preparation method according to claim 4, it is characterised in that: the ethyl alcohol proposes the solid-liquid mass ratio proposed with water and is
1:8.
8. the preparation method according to claim 4, it is characterised in that: described and pharmaceutically acceptable pharmaceutic adjuvant system
It is standby, for appropriate amount of starch, magnesium stearate are added into the antirheumatic extract that claim 4 obtains, by the prior art
Tablet is made in conventional method；Wherein, the meter of total amount containing alkaloid in every, must not be less than 1mg.
9. the preparation method according to claim 4, it is characterised in that: described and pharmaceutically acceptable pharmaceutic adjuvant system
It is standby, for appropriate amount of starch, magnesium stearate are added into the antirheumatic drug compositions that claim 4 obtains, by the prior art
Capsule is made in conventional method；Wherein, the meter of total amount containing alkaloid in every capsule must not be less than 1mg.
10. the preparation method according to claim 4, it is characterised in that: described and pharmaceutically acceptable pharmaceutic adjuvant system
It is standby, for appropriate amount of starch, magnesium stearate are added into the antirheumatic drug compositions that claim 4 obtains, by the prior art
Granule is made in conventional method；Wherein, the meter of total amount containing alkaloid in every bag, must not be less than 3mg.
11. pharmaceutical composition as claimed in claim 2 is preparing the application in antirheumatic.
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| CN102895334A (en) * | 2011-07-29 | 2013-01-30 | 苏州知微堂生物科技有限公司 | Preparation technology and production method for integrated new formulation of licorice and monkshood decoction |
| CN104688846A (en) * | 2013-12-04 | 2015-06-10 | 王晓娟 | acute rheumatoid arthritis |
| CN104689144A (en) * | 2013-12-09 | 2015-06-10 | 黄思齐 | Drug for treating rheumatoid arthritis |
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