CN106177048A - One treats uremic Chinese medicine composition and preparation method thereof - Google Patents
One treats uremic Chinese medicine composition and preparation method thereof Download PDFInfo
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- CN106177048A CN106177048A CN201610649159.5A CN201610649159A CN106177048A CN 106177048 A CN106177048 A CN 106177048A CN 201610649159 A CN201610649159 A CN 201610649159A CN 106177048 A CN106177048 A CN 106177048A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses one and treat uremic Chinese medicine composition, described Chinese medicine composition is made up of the raw material of following weight portion: Folium Kaki 25 35 parts, 10 15 parts, Radix Euphorbiae Pekinensis, Ramulus Cinnamomi 5 10 parts, the Radix Astragali 5 15 parts, the Radix Angelicae Dahuricae 11 16 parts, Hedyotidis Diffusae 11 15 parts, Semen Plantaginis 10 12 parts, Radix Angelicae Sinensis 69 parts, Radix Morindae Officinalis 8 10 parts, Semen Cuscutae 69 parts, 25 parts of Flos Carthami, Fructus Psoraleae 8 12 parts.Chinese medicine composition disclosed by the invention, each component all uses natural raw material of Chinese medicine, and its preparation is easy, medicine source is wide, low cost.The present invention follows the prescriptions principle of the traditional Chinese medical science, and various component drug use the use that is decocted in water for oral dose.Verify by clinic application, treatment uremia evident in efficacy reliably, mild in medicine property and, do not occur that toxic and side effects, effective percentage reach 90%, cure rate 30.0%.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to one and treat uremic Chinese medicine composition and preparation side thereof
Method.
Background technology
Nephropathy is the diseases of urinary system of one group of serious harm people's health, most recurrent exerbation, and delay difficulty more, is controlled
Treat difficulty the biggest.Particularly when nephropathy is through repeatedly showing effect, the state of an illness can not get controlling or not obtaining the effective treatment, and all may
Develop into renal failure, finally develop into uremia.And once develop into uremia, it is equal to indirectly declare the kidney of patient
Function will be completely lost.Killer's type disease that it is referred to as by physician, and have the trend being gradually increased in recent years.Due to kidney
Sick pathogeny is sufficiently complex, and clinical manifestation is varied, therefore, there is no the specific medicament for the treatment of nephropathy in the market.
Western medical treatment typically uses antibiotics to treat, although this therapy onset is very fast, can alleviate disease, but Long-term taking medicine
Bring bigger side effect easily to the most defective nephrotic of renal function.
Uremia refers to when acute or chronic renal insufficiency develops into severe stage, due to metabolite accumulation and water, electricity
Solve matter and acid base imbalance so that a series of self poisoning symptoms that endocrine function is lacked of proper care and caused body to occur are referred to as
Uremia.Uremia's disguise is high, have the title of " stealthy killer ".And the rate of sending out is high, has again the title of " the second cancer ".Disease
Shape includes poor appetite, nausea and vomiting, headache, weak and frequent urination at night etc., has abnormal flavour, stomatocace, nose to go out in most disease populations
Blood or digestive tract hemorrhage, there is also the neural essences such as absent minded, bradykinesia, numb limbs and tense tendons, drowsiness or restlessness
God's symptom.At present, the most commonly seen Rend dialysis created no more than doctor trained in Western medicine of uremia and renal transplantation are treated: for dialysis, be
A kind of the most direct way of the quick body endotoxin removing of energy, but patient is in addition to must endure as huge financial burden, to human body
Itself also it is a kind of to injure and have strict indication and taboo;For kidney transplantation, kidney source is few, distribution type is difficult, success rate is little, repulsion
Phenomenon is difficult to solve for the moment, adds somewhat expensive, often makes patient suffer untold misery even and hang back.Relative, the traditional Chinese medical science is then
Overcome some of which problem, such as clysmata to a certain extent, have certain colonic dialysis effect, be nitrogen in purged body
One important channel of matter, supplementing for oral drugs, especially to can not the patient of oral drugs the most suitable.
Summary of the invention
It is an object of the invention to provide a kind of with low cost, toxic and side effects is little, effect significantly treats uremic Chinese medicine
Compositions.
The second object of the present invention is to provide the preparation method of described Chinese medicine composition.
For achieving the above object, present invention firstly provides one and treat uremic Chinese medicine composition, described Chinese medicine composition
Thing is made up of the raw material of following weight portion: Folium Kaki 25-35 part, Radix Euphorbiae Pekinensis 10-15 part, Ramulus Cinnamomi 5-10 part, Radix Astragali 5-15 part, the Radix Angelicae Dahuricae
11-16 part, Hedyotidis Diffusae 11-15 part, Semen Plantaginis 10-12 part, Radix Angelicae Sinensis 6-9 part, Radix Morindae Officinalis 8-10 part, Semen Cuscutae 6-9 part, Flos Carthami
2-5 part, Fructus Psoraleae 8-12 part.
Preferably, described Chinese medicine composition is made up of the raw material of following weight portion: Folium Kaki 30 parts, 12 parts, Radix Euphorbiae Pekinensis, Ramulus Cinnamomi 7
Part, the Radix Astragali 8 parts, the Radix Angelicae Dahuricae 12 parts, Hedyotidis Diffusae 12 parts, Semen Plantaginis 11 parts, Radix Angelicae Sinensis 6 parts, Radix Morindae Officinalis 9 parts, Semen Cuscutae 8 parts, Flos Carthami 4
Part, Fructus Psoraleae 10 parts.
Preferably, the dosage form of described Chinese medicine composition includes capsule, tablet, powder or granule.
Used by the present invention, each component pharmacologic action is as follows:
Folium Kaki, bitter in the mouth, cold in nature, nontoxic, enter lung meridian, Folium Kaki is used as medicine the most with a long history, its effect " book on Chinese herbal medicine is new ",
In the medical science ancient books and records such as " book on Chinese herbal medicine derivative ", " Chinese herbology ", " Chinese medicine voluminous dictionary " the most on the books.The traditional Chinese medical science is thought: Folium Kaki can be with cephalocathartic
Improving eyesight, anti inflammation and heat resolution, reduce blood pressure, increase heart coronary artery blood flow, prevent effect such as synthesis of inferior ammonium nitrate in human body,
Often drink and can promote body tissue metabolism.It contains rutin, choline, protein, mineral, sugar etc., and prominent is every
In 100 grams of dry Folium Kaki, Determination of Vitamin C reaches about 3500 milligrams.National distinguished veteran doctors of TCM is old always explicitly points out: Folium Kaki is the least
Just, logical stool, have positive effect purifying the blood, in terms of vessel softening, blood pressure lowering.The experience of Yi Shi China national level distinguished veteran doctors of TCM is used
Medicine, many gather materials also demonstrate this point.Additionally, modern study also demonstrates that in Folium Kaki containing Folium Kaki pyrite glycoside, ursolic acid
Deng the component useful to nephropathy.
Radix Euphorbiae Pekinensis, bitter, cold;Return lung, spleen, kidney channel.Removing fluid-retention by purgation.For edema distension, chest and abdomen hydrops, phlegm retention accumulation, gas
Against breathing with cough, difficulty in urination and defecation.
Ramulus Cinnamomi, acrid, sweet, warm, GUIXIN, lung, bladder warp, diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For
Anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
The Radix Astragali, nature and flavor are sweet, warm, return lung, spleen channel, invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weary for the deficiency of vital energy
Power, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and bursts for a long time and does not holds back, blood
Empty dull yellowish colored skin, interior-heat is quenched one's thirst;Chronic nephritis proteinuria, diabetes.
The Radix Angelicae Dahuricae, pungent, warm, return stomach, large intestine, lung meridian, dissipate wind dehumidifying, sensible pain relieving, detumescence and apocenosis.
Hedyotidis Diffusae, sweet, light, cool;Enter stomach, large intestine, small intestine meridian, heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For intestinal
Carbuncle (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the disease such as dysuria;Furuncle carbuncle, venom are controlled in external.
Semen Plantaginis, sweet, be slightly cold, return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, and improving eyesight is eliminated the phlegm.For edema
Distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.
Radix Angelicae Sinensis, sweet, acrid, warm, return liver, the heart, spleen channel, replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy
Dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Radix Morindae Officinalis, sweet, pungent, tepor;Return kidney, Liver Channel, kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is not
Pregnant, menoxenia, few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Semen Cuscutae, sweet, warm, return liver,kidney,spleen warp.Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.Lose for sexual impotence
Essence, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down.
Flos Carthami, pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen painful abdominal mass
Block, injury from falling down, skin infection swells and ache.
Fructus Psoraleae, pungent, bitter, temperature.Return kidney, spleen channel.Warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, waist
Knee joint cold type of pain, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea.
Pharmaceutical formulation of the present invention is with Folium Kaki, Radix Euphorbiae Pekinensis as monarch drug, dispersing cold for relieving pain, warming the meridian for stopping bleeding, removing fluid-retention by purgation;With osmanthus
Branch, the Radix Astragali, the Radix Angelicae Dahuricae, Hedyotidis Diffusae, Semen Plantaginis are ministerial drug, the hemostasis of nourishing the liver and kidney, promoting the flow of QI-blood by warming the meridian, dissipating blood stasis, subduing swelling and relieving pain;To work as
Return, Radix Morindae Officinalis, Semen Cuscutae, Flos Carthami and Fructus Psoraleae are adjuvant drug, invigorating the spleen and replenishing QI, promoting blood circulation to restore menstrual flow, warming the kidney to activate YANG;The collaborative tool of above-mentioned all medicines
There is kidney tonifying supporing yang, regulating the flow of QI to ease the stomach, expelling wind and removing dampness, clearing away heat and promoting diuresis, supplementing the kidney to control the nocturnal, nourishing the liver and kidney, inducing diuresis to remove edema, removing toxicity for eliminating carbuncles, right
There is the most significant therapeutic effect in uremia.
Further, the invention provides one and prepare Chinese medicine composition method, it comprises the following steps:
(1) prepare Folium Kaki, Folium Kaki is carried out, selects, goes handle, parch and pulverizing;
(2) weigh other each crude drug according to formula proportion, pulverize respectively, standby;
(3) taking all medical materials, add medical material weight 5-8 times weight water and soak 1-2 hour, intense fire decocts boiling 5-10 and divides
Clock, then with slow fire boiling 3-5 hour, filter, obtain filtrate;Adding 2-4 times of weight water of initial medical material in filtering residue, intense fire decocts
Seething with excitement 5-10 minute, then with slow fire boiling 1-2 hour, filter, obtain filtrate and retain filtering residue, merging twice filtrate, filtrate is dense
It is reduced to the concentrated solution that relative density is 1.20-1.25 standby;
(4) filtering residue of (3) is added the ethanol of concentration 65-80% of initial 2-3 times of weight of medical material, reflux, extract, 2 times, every time
2-5 hour, filtering, merging filtrate, decompression is distilled off ethanol, and to be concentrated into 55 DEG C of-60 DEG C of relative densities be 1.20-1.25's
Concentrated solution is standby;
(5) being merged by the concentrated solution of step (3) and (4) gained, continuing to be concentrated into 55 DEG C of-60 DEG C of relative densities is 1.3-
The extractum of 1.5, obtains pharmaceutical composition of the present invention.
Beneficial effect
Chinese medicine composition disclosed by the invention, each component all uses natural raw material of Chinese medicine, its preparation is easy, medicine source is wide,
Low cost.The present invention follows the prescriptions principle of the traditional Chinese medical science, and various component drug use the use that is decocted in water for oral dose.Verify by clinic application,
Treatment uremia in evident in efficacy reliably, mild in medicine property and, do not occur that toxic and side effects, effective percentage reach 90%, cure rate 30.0%.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.If not specializing, embodiment
The conventional means that technological means used by is well known to those skilled in the art.
The compatibility 1 of embodiment 1 persimmon fruit leaves health-care tea and preparation method
Each parts by weight of raw materials is as follows: Folium Kaki 30 parts, 12 parts, Radix Euphorbiae Pekinensis, Ramulus Cinnamomi 7 parts, the Radix Astragali 8 parts, the Radix Angelicae Dahuricae 12 parts, Agkistrodon
Grass 12 parts, Semen Plantaginis 11 parts, Radix Angelicae Sinensis 6 parts, Radix Morindae Officinalis 9 parts, Semen Cuscutae 8 parts, 4 parts of Flos Carthami, Fructus Psoraleae 10 parts.
Preparation method is as follows:
(1) prepare Folium Kaki, gather the Folium Kaki fresh, without pest and disease damage, without pesticide in 4-6 month and be carried out;Remove Folium Kaki
Petiole, and Folium Kaki is torn into less leaf block, drains with after clean water;Subsequently with iron pan parch Folium Kaki, the temperature of parch
It is advisable with 50-60 DEG C, and notes during parch stirring Folium Kaki, to prevent Folium Kaki by parching to brown, affect the treatment;
(2) weigh other each crude drug according to formula, pulverize respectively, standby;
(3) taking all medical materials, add 6 times of weight water of medical material weight and soak 1.5 hours, intense fire decocts boiling 5 minutes, then uses
Slow fire boiling 4 hours, filters, obtains filtrate;Adding 3 times of weight water of initial medical material in filtering residue, intense fire decocts boiling 5 minutes,
Again with slow fire boiling 2 hours, filtering, obtain filtrate and retain filtering residue, merging twice filtrate, filtrate is concentrated into relative density and is
The concentrated solution of 1.2 is standby;
(4) filtering residue of (3) is added the ethanol of the concentration 70% of initial 3 times of weight of medical material, reflux, extract, 2 times is each 3 little
Time, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of-60 DEG C of relative densities are 1.20
With;
(5) being merged by the concentrated solution of step (3) and (4) gained, continuing to be concentrated into 55 DEG C of-60 DEG C of relative densities is 1.4
Extractum, obtains pharmaceutical composition of the present invention.
The compatibility 2 of embodiment 2 persimmon fruit leaves health-care tea and preparation method
Each parts by weight of raw materials is as follows: Folium Kaki 25 parts, 15 parts, Radix Euphorbiae Pekinensis, Ramulus Cinnamomi 8 parts, the Radix Astragali 6 parts, the Radix Angelicae Dahuricae 14 parts, Agkistrodon
Grass 11 parts, Semen Plantaginis 10 parts, Radix Angelicae Sinensis 7 parts, Radix Morindae Officinalis 10 parts, Semen Cuscutae 9 parts, 5 parts of Flos Carthami, Fructus Psoraleae 8 parts.
Preparation method is as follows:
(1) prepare Folium Kaki, gather the Folium Kaki fresh, without pest and disease damage, without pesticide in 4-6 month and be carried out;Remove Folium Kaki
Petiole, and Folium Kaki is torn into less leaf block, drains with after clean water;Subsequently with iron pan parch Folium Kaki, the temperature of parch
It is advisable with 50-60 DEG C, and notes during parch stirring Folium Kaki, to prevent Folium Kaki by parching to brown, affect the treatment;
(2) weigh other each crude drug according to formula, pulverize respectively, standby;
(3) taking all medical materials, add 5 times of weight water of medical material weight and soak 2 hours, intense fire decocts boiling 5 minutes, then with civilian
Fire decocts 3 hours, filters, obtains filtrate;Adding 3 times of weight water of initial medical material in filtering residue, intense fire decocts boiling 5 minutes, then
With slow fire boiling 1 hour, filtering, obtain filtrate and retain filtering residue, merging twice filtrate, it is 1.25 that filtrate is concentrated into relative density
Concentrated solution standby;
(4) filtering residue of (3) is added the ethanol of the concentration 80% of initial 3 times of weight of medical material, reflux, extract, 3 times is each 2 little
Time, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of-60 DEG C of relative densities are 1.25
With;
(5) being merged by the concentrated solution of step (3) and (4) gained, continuing to be concentrated into 55 DEG C of-60 DEG C of relative densities is 1.5
Extractum, obtains pharmaceutical composition of the present invention.
The compatibility 3 of embodiment 3 persimmon fruit leaves health-care tea and preparation method
Each parts by weight of raw materials is as follows: Folium Kaki 35 parts, 10 parts, Radix Euphorbiae Pekinensis, Ramulus Cinnamomi 6 parts, the Radix Astragali 15 parts, the Radix Angelicae Dahuricae 11 parts, Agkistrodon
Grass 15 parts, Semen Plantaginis 12 parts, Radix Angelicae Sinensis 9 parts, Radix Morindae Officinalis 8 parts, Semen Cuscutae 6 parts, 3 parts of Flos Carthami, Fructus Psoraleae 12 parts.
Preparation method is with embodiment 1.
Clinical practice example
1, clinical observation case 10 example, age 30~80 years old, male 5 examples, female 5 example, the longest course of disease 10 years, the shortest 6 months.
Protopathy, chronic glomerulonephritis 5 example, pyelonephritis 2 example, latent nephritis 1 example, hypertension with renal injury 1 example, kidney
Disease syndrome 1 example, Lupus nephritis 2 example.
2, diagnostic criteria:
About the diagnostic criteria of chronic renal failure (CRF) uremia: (1) endogenous creatinine clearance rate (CCr) < 25%;(2)
Serum creatinine (Cr) > 451umol/L;(3) blood urea nitrogen (BUN) > 17.9mmol/L;(4) obvious anemia, symptom of digestive tract;(5) generation
Thanking property acidosis.
Meeting Chinese and western medicine diagnostic criteria, Chinese medical discrimination is failure of kidney-YANG, adverse flow of turbid QI, puffiness of the face and limbs, poor appetite abdominal distention, purplish tongue
Dark white, slippery and moist fur, irregularly intermittent and regularly intermittent pulse.
2, usage and dosage: during clinical practice, the component in compositions takes the circumstances into consideration increase and decrease according to body weight and the age of patient.One day
Potion, decocting twice extracting juice about 300ml, divides and takes for early, middle and late three times.Within one month, it is a course for the treatment of, 2 courses for the treatment of of treatment continuously.
3, criterion of therapeutical effect:
Observe BUN (blood urea nitrogen), Cr (serum creatinine), HGB (hemoglobin), ALB (serum before and after clinical efficacy and treatment
Albumin) situation of change.
Clinical recovery: symptom is wholly absent, observation item major part, in normal range, follows up a case by regular visits to half a year without recurrence;
Effective: BUN declines >=30%, Cr declines >=30%, and symptom alleviates or disappears;
Effective: BUN, Cr all decline >=20%, symptom is improved;
Stablizing BUN, Cr without deterioration or to be declined slightly, symptom has improvement;
Before and after treatment, Sx does not alleviates or increases the weight of, and BUN, Cr are not improved or raise before relatively treatment.
4, therapeutic effect: in this clinical observation case, take medicine 1-3 the course for the treatment of, 3 examples of fully recovering, effective 3 examples, effective 3 examples, nothing
Imitate 1 example.Toxic and side effects does not occurs during treatment, and effective percentage reaches 90%, cure rate 30.0%.
Clinical practice special case
Zhao, female, 56 years old, limbs fatigue, occur hematuria, dysurea and occur edema etc. symptom, through being diagnosed as: chronic renal
Scorching late stage uremia, took the health beverage of the present invention after 3 months, and clinical symptoms is substantially alleviated.
Although, the present invention is described in detail the most with a general description of the specific embodiments, but
On the basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (4)
1. treat uremic Chinese medicine composition for one kind, it is characterised in that described Chinese medicine composition is by the raw material of following weight portion
Composition: Folium Kaki 25-35 part, Radix Euphorbiae Pekinensis 10-15 part, Ramulus Cinnamomi 5-10 part, Radix Astragali 5-15 part, Radix Angelicae Dahuricae 11-16 part, Hedyotidis Diffusae 11-
15 parts, Semen Plantaginis 10-12 part, Radix Angelicae Sinensis 6-9 part, Radix Morindae Officinalis 8-10 part, Semen Cuscutae 6-9 part, Flos Carthami 2-5 part, Fructus Psoraleae 8-12 part.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that described Chinese medicine composition is by the raw material of following weight portion
Composition: Folium Kaki 30 parts, 12 parts, Radix Euphorbiae Pekinensis, Ramulus Cinnamomi 7 parts, the Radix Astragali 8 parts, the Radix Angelicae Dahuricae 12 parts, Hedyotidis Diffusae 12 parts, Semen Plantaginis 11 parts, when
Return 6 parts, Radix Morindae Officinalis 9 parts, Semen Cuscutae 8 parts, 4 parts of Flos Carthami, Fructus Psoraleae 10 parts.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterised in that the dosage form of described Chinese medicine composition includes capsule
Agent, tablet, powder or granule.
4. preparing a Chinese medicine composition method, it comprises the following steps:
(1) prepare Folium Kaki, Folium Kaki is carried out, selects, goes handle, parch and pulverizing;
(2) weigh other each crude drug according to formula proportion, pulverize respectively, standby;
(3) taking all medical materials, add medical material weight 5-8 times weight water and soak 1-2 hour, intense fire decocts boiling 5-10 minute, then
With slow fire boiling 3-5 hour, filter, obtain filtrate;Adding 2-4 times of weight water of initial medical material in filtering residue, intense fire decocts boiling
5-10 minute, then with slow fire boiling 1-2 hour, filter, obtain filtrate and retain filtering residue, merging twice filtrate, filtrate is concentrated into
Relative density is that the concentrated solution of 1.20-1.25 is standby;
(4) filtering residue of (3) is added the ethanol of concentration 65-80% of initial 2-3 times of weight of medical material, reflux, extract, 2 times, each 2-5
Hour, to filter, merging filtrate, decompression is distilled off ethanol, and to be concentrated into 55 DEG C of-60 DEG C of relative densities be the dense of 1.20-1.25
Contracting liquid is standby;
(5) being merged by the concentrated solution of step (3) and (4) gained, continuing to be concentrated into 55 DEG C of-60 DEG C of relative densities is 1.3-1.5's
Extractum, obtains pharmaceutical composition of the present invention.
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Application publication date: 20161207 |