CN102631394B - Traditional Chinese medicine composition capable of improving immunity and resisting fatigue - Google Patents
Traditional Chinese medicine composition capable of improving immunity and resisting fatigue Download PDFInfo
- Publication number
- CN102631394B CN102631394B CN201210122009.0A CN201210122009A CN102631394B CN 102631394 B CN102631394 B CN 102631394B CN 201210122009 A CN201210122009 A CN 201210122009A CN 102631394 B CN102631394 B CN 102631394B
- Authority
- CN
- China
- Prior art keywords
- compositions
- spirulina
- herba epimedii
- resisting fatigue
- immunity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 230000036039 immunity Effects 0.000 title claims abstract description 20
- 239000003814 drug Substances 0.000 title claims description 21
- 240000002900 Arthrospira platensis Species 0.000 claims abstract description 32
- 235000016425 Arthrospira platensis Nutrition 0.000 claims abstract description 32
- 241000208340 Araliaceae Species 0.000 claims abstract description 31
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 30
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 30
- 235000008434 ginseng Nutrition 0.000 claims abstract description 30
- 229940082787 spirulina Drugs 0.000 claims abstract description 29
- 230000000694 effects Effects 0.000 claims abstract description 17
- 238000005728 strengthening Methods 0.000 claims abstract description 11
- 230000036541 health Effects 0.000 claims abstract description 8
- 210000003734 kidney Anatomy 0.000 claims abstract description 7
- TZJALUIVHRYQQB-XFDQAQKOSA-N Icariin Natural products O(C)c1ccc(C2=C(O[C@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)C(=O)c3c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)c(C/C=C(\C)/C)c3O2)cc1 TZJALUIVHRYQQB-XFDQAQKOSA-N 0.000 claims description 19
- TZJALUIVHRYQQB-XLRXWWTNSA-N icariin Chemical compound C1=CC(OC)=CC=C1C1=C(O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)C(=O)C2=C(O)C=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-XLRXWWTNSA-N 0.000 claims description 19
- TZJALUIVHRYQQB-UHFFFAOYSA-N icariine Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(C)O2)O)C(=O)C2=C(O)C=C(OC3C(C(O)C(O)C(CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-UHFFFAOYSA-N 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 14
- 239000002994 raw material Substances 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 2
- 230000002929 anti-fatigue Effects 0.000 claims 2
- 230000006870 function Effects 0.000 abstract description 12
- 230000002708 enhancing effect Effects 0.000 abstract description 8
- 239000004480 active ingredient Substances 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 20
- 238000012360 testing method Methods 0.000 description 20
- 239000002775 capsule Substances 0.000 description 14
- 241000699666 Mus <mouse, genus> Species 0.000 description 11
- 201000001881 impotence Diseases 0.000 description 11
- 230000037396 body weight Effects 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 239000003826 tablet Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 208000010228 Erectile Dysfunction Diseases 0.000 description 7
- 210000000952 spleen Anatomy 0.000 description 7
- 229940079593 drug Drugs 0.000 description 5
- 230000036737 immune function Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000001568 sexual effect Effects 0.000 description 5
- 230000009182 swimming Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 230000000242 pagocytic effect Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- LOTKRQAVGJMPNV-UHFFFAOYSA-N 1-fluoro-2,4-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(F)C([N+]([O-])=O)=C1 LOTKRQAVGJMPNV-UHFFFAOYSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000003111 delayed effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 238000009863 impact test Methods 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 210000003024 peritoneal macrophage Anatomy 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000007670 refining Methods 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 210000001541 thymus gland Anatomy 0.000 description 3
- 230000007306 turnover Effects 0.000 description 3
- 241000192700 Cyanobacteria Species 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000012669 liquid formulation Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- IYCPMVXIUPYNHI-WPKKLUCLSA-N 3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one Chemical compound C1=CC(OC)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(CC=C(C)C)=C2O1 IYCPMVXIUPYNHI-WPKKLUCLSA-N 0.000 description 1
- 206010061623 Adverse drug reaction Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 241000133570 Berberidaceae Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010006464 Hemolysin Proteins Proteins 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 210000002534 adenoid Anatomy 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 230000002605 anti-dotal effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 210000000628 antibody-producing cell Anatomy 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000003228 hemolysin Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000001662 opsonic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000003236 psychic effect Effects 0.000 description 1
- 230000001107 psychogenic effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000009613 pulmonary function test Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000009666 routine test Methods 0.000 description 1
- 238000007560 sedimentation technique Methods 0.000 description 1
- -1 sieves Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a health care product composition capable of improving human body immunity and resisting fatigue. The composition comprises the following active ingredients: ginseng, spirulina and herba epimedii. The composition has the functions of enhancing organism immunity, resisting fatigue, tonifying the kidney, strengthening yang and building bodies, and has obvious curative effects and mild effects.
Description
Technical field
The present invention relates to a kind of collaborative Chinese medicine composition that improves body immunity, resisting fatigue and kidney invigorating and Yang strengthening function that has.
Technical background
Along with socioeconomic development, the raising day by day of people's living standard, people increase gradually to the degree of keeping a grip on of health, live in now be all, we easily receive many outside threats at everyone health, comprise air pollution, video pollution, environmental pollution, operating pressure, economic pressures, bacterial virus, improper diet etc.Moreover the variation due to city work, rhythm of life, be easy to make the people to produce confirmed fatigue, i.e. sub-health state, the factor of all these unfavorable health, usually can make us spiritual and can not concentrate, hypomnesis, often indolent and listless, old and feeble ahead of time.Therefore improve autoimmunity, the ability that strengthens the various unfavorable health factors of antagonism is most important.
The current health product for enhancing human body immunity power on the market are of a great variety, but action effect is uneven.
Summary of the invention
The technical problem to be solved in the present invention is: the Chinese medicine composition that the purpose of this invention is to provide a kind of enhancing human body immunity power, resisting fatigue and kidney invigorating and Yang strengthening function.By take Radix Ginseng, spirulina and Herba Epimedii as main Chinese crude drug, by mutual synergistic function, to improving resistance against diseases, strengthen immune effect, the engineering of alleviating physical fatigue and kidney invigorating and Yang strengthening function.
For solving the problems of the technologies described above, the invention provides a kind of collaborative Halth-care composition that improves body immunity, resisting fatigue that has, it is characterized in that described compositions comprises a kind of Halth-care composition that has Synergistic raising human body immunity of organisms, resisting fatigue and have kidney invigorating and Yang strengthening function of active component, is characterized in that described compositions comprises Radix Ginseng, spirulina, Herba Epimedii.In active component by weight: Radix Ginseng 3-65 part, spirulina 4-60 part, Herba Epimedii 4-60 part.Preferably ginseng 4-40 part, spirulina 7-40 part, Herba Epimedii 8-50 part.
Preferably the weight proportion of each component is: 65 parts of Radix Ginsengs, spirulina 6) part, 60 parts of Herba Epimedii.
Preferably the weight proportion of each component is: Radix Ginseng is 3 parts, 4 parts of spirulinas, 4 parts of Herba Epimedii.
Preferably the weight proportion of each component is: 20 parts of Radix Ginsengs, 25 parts of spirulinas, 35 parts of Herba Epimedii.
Preferably the weight proportion of each component is: 40 parts of Radix Ginsengs, 40 parts of spirulinas, 50 parts of Herba Epimedii.
In the present invention, related Radix Ginseng refers to the general name of a kind of herbaceos perennial of the Umbellales Araliaceae Radix Ginseng Panax of family, comprises Radix Ginseng Rubra, Radix Ginseng, Radix Panacis Quinquefolii (Radix Panacis Quinquefolii), Radix Glehniae, Radix Codonopsis and Radix Pseudostellariae etc.Radix Ginseng in the present invention comprises Radix Ginseng extract, the various forms in grinding descendant's pure extract powder or during Ginseng Growth after processing is refined.
Involved in the present invention to spirulina refer to the class rudimentary plant belonged in Cyanophyta, Cyanophyceae, hormocystangium order, Oscillariaceae, Spirullina, mainly comprise spirulina maxim, spirulina plalensis.Spirulina in the present invention comprises other processing forms of refining rear screw algae extract or spirulina through processing.
The Herba Epimedii arrived involved in the present invention, can be Berberidaceae plant Herba Epimedii, arrow leaf Herba Epimedii, pubescence Herba Epimedii, or the dried leaves of Herba Epimedii.Herba Epimedii in the present invention is hidden Herba Epimedii powder, icariin, icariin I, the Herba Epimedii A etc. through refining that comprise after grinding.
After in the present invention, the definition of " collaborative improve " can be understood as several medical materials combinations, the raising of its drug effect during with respect to independent the use; Drug effect is more lasting; Compositions produces beyond thought effect in new control or healthcare field.
In component of the present invention, the Radix Ginseng strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves, strong taste.Spirulina has the opsonic immunity function, reduces cholesterol, promoting digestion, protecting liver, anticancer, antidotal effect.Herba Epimedii has the enhancing human body immunity function, kidney-replenishing, and bone and muscle strengthening, wind-damp dispelling, improve microcirculation, increases blood flow, increases coronary flow and antitussive, eliminates the phlegm, anti-hypoxia, calmness, anticonvulsant effect.
The inventor finds by test, compositions of the present invention has significant synergistic function on the pathology that improves body immunity, resisting fatigue, as compositions of the present invention has outside the effect that improves body immunity, resisting fatigue, there is the effect of improving male's sexual simultaneously.These single doses are that single dose is incomparable to the action effect of some function of human body after by a certain proportion of compositions.
Compositions of the present invention, can directly pulverize or the active component as the refining compositions as treating of extraction of decoction and alcohol sedimentation technique or ethanol extract from water precipitation through the conventional extractive technique in this area.Described active component can be made various pharmaceutical formulations with pharmaceutically acceptable carrier or excipient composition, as is how granular tablet, granule, capsule, or oral liquid etc.According to using needs, compositions of the present invention also can be processed into slow releasing preparation or quick releasing formulation.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These carriers used or excipient can determine for the those of ordinary skill of pharmaceutical field.
The preparation method of oral liquid, can but not only be confined to following a kind of, after active component is mixed, decoct with water, decoction liquor is filtered, obtain solution, by the concentrated extractum that obtains of gained solution, the concentration that then gained extractum is dissolved in 5-10 times of weight of extractum weight, in the ethanol water according to weighing scale 95%, is uniformly mixed, quantitative separating, obtain oral liquid formulations.
The preparation method of tablet is that the active component mixture is sieved, and after pulverizing, fully mix homogeneously at the auxiliary agent commonly used with preparing tablet, crosses the 40-80 eye mesh screen, by tabletting, the direct machine of dry powder is pressed into to tablet.
The preparation technology of capsule preparations can be, the active component mixture is sieved, and after pulverizing, fully mix homogeneously at the auxiliary agent commonly used with preparing tablet, crosses the 40-80 eye mesh screen, and by granulating, drying, fill with capsule after the operations such as granulate, and polishing is packed, and gets product.
The invention has the beneficial effects as follows:
Pharmaceutical composition of the present invention has benefiting QI for strengthening the superficies, improve the immunity of organisms effect, medicine of the present invention is not warm not dry, there is invigorating spleen and reinforcing stomach, improve microcirculation in human body, the effect of wet dissipation eliminating impediment, enhancing immunity, resisting fatigue, antiviral, strengthening body, evident in efficacy, action temperature and, have no side effect.The production technology of this medicine is simple, be easy to take, and is a kind of desirable raising human immunity, the medicine of resisting fatigue.
Detailed description of the preferred embodiments
Following examples have illustrated the each aspect of the present invention content.They only, in order to explanation, not delimit the scope of the invention.
Embodiment 1: the capsule that contains Radix Ginseng, spirulina and icariin
Radix Ginseng 65 grams, spirulina 60 grams, icariin 60 grams.
Above-mentioned Chinese medicine is soaked 40 minutes, the water surface is important higher than raw material, adding water inventory is 8 times of total dose, the rear little fire that the boils state of boiling, maintain liquid level higher than raw material Chinese medicine height, decocts 2 hours, cross leaching filtrate, the water of 6 times that adds again total dose, the rear little fire that the boils state of boiling, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter to merge twice filtrate, through concentrating under reduced pressure (pressure 0.06MPa, 65 ℃ of temperature) to dry cream, pulverize, through 300 mesh sieves, add the magnesium stearate of gross weight 2%, incapsulate and get final product.
Embodiment 2: contain the tablet that the people participates in spirulina and icariin
Radix Ginseng 3 grams, spirulina 4 grams, icariin 4 grams.
Above-mentioned Chinese crude drug is dried and crushed into to coarse powder, take the ethanol of 50-60% as solvent 60-70 ℃ of reflux, extract,, extracting solution is being gone out after ethanol, cryoconcentration becomes thick extractum, dry, pulverize into fine powder, sieves, and mixes, and granulates, and is pressed into tablet.
Embodiment 3: the capsule that contains Radix Ginseng, spirulina and icariin
Radix Ginseng 20 grams, spirulina 25 grams, icariin 35 grams.
Above-mentioned Chinese crude drug is dried and crushed into to fine powder, sieves, mix, pack into firmly softgel shell, make Chinese medicine composition of the present invention.
Embodiment 4: the oral liquid that contains Radix Ginseng, spirulina and icariin
Radix Ginseng 40 grams, spirulina 40 grams, icariin 50 grams.
After said components is mixed, decoct with water, decoction liquor is filtered, obtain solution, by the concentrated extractum that obtains of gained solution, then gained extractum is dissolved in the concentration of 5-10 times of weight of extractum weight in the ethanol water according to weighing scale 95%, be uniformly mixed, quantitative separating, obtain oral liquid formulations.
Embodiment 5: the tablet that contains Radix Ginseng, spirulina and icariin
Radix Ginseng 17 grams, spirulina 16 grams, icariin 60 grams
Above-mentioned Chinese crude drug is dried and crushed into to coarse powder, take the ethanol of 50-60% as solvent 60-70 ℃ of reflux, extract,, extracting solution is being gone out after ethanol, cryoconcentration becomes thick extractum, dry, pulverize into fine powder, sieves, and mixes, and granulates, and is pressed into tablet.
Test example 1: the impact test of the present invention on immune function of mice
1, the product of testing product: embodiment 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 is sample.
2, detect and use animal: mice, rat, male and female half and half.
3, test basis: Ministry of Public Health " health food check and assessment technique standard " (2003 editions)
4, test item:
4.1 body weight, thymus/body weight ratio, spleen/body weight ratio
4.2comA the mouse spleen lymphocyte transformation experiment (mtt assay) of inducing
4.3 the mice Delayed onset allergy (DTH) that dinitrofluorobenzene is induced
4.4 antibody-producting cell detects (Jerne improves slide method)
4.5 serolysin test
4.6 mice carbon clearance test
4.7 Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell experiment (dripping the sheet method)
4.8NK cytoactive detection
5, testing result and judgement
5.1 the body weight of laboratory animal, thymus/body weight ratio, the testing result of spleen/body weight ratio shows, under this experimental condition, institute's full pattern product 500,1000,3000mg during kg (be equivalent to respectively be grown up per kg body weight per day recommended intake 5 times, 10 times, 30 times) dosage, five groups of samples body weight to animal, thymus/body weight ratio, spleen/body weight ratio is showed no obvious impact.
5.2comA mouse spleen lymphocyte transformation experiment (mtt assay) result of inducing shows, under this experiment condition, each dosage group optical density difference and solvent control class value relatively, all without statistical significant difference (P>0.05).The prompting sample is without strengthening the mouse lymphocyte multiplication capacity.
5.3 mice Delayed onset allergy (DTH) result that dinitrofluorobenzene is induced shows, under this experiment condition, each dosage group optical density difference and solvent control class value relatively, all without statistical significant difference (P>0.05).The prompting sample has the mice Delayed onset allergy effect that the enhancing dinitrofluorobenzene causes.The test dose group is positive, and the prompting sample can strengthen the mouse cell immunologic function.
5.4 detecting (Jerne improves slide method) result, antibody-producting cell shows, under this experimental condition, each dosage group hemolysis plaque number is all higher than the solvent control class value, and low, middle dosage group has statistically-significant difference (P<0.05), the prompting sample has the ability that mice produces antibody producing cells that strengthens.
5.5 the serolysin test result shows, under this experiment condition, each dosage group mice serum half hemolysis value and solvent control class value relatively, all without statistically-significant difference (P>0.05).The prompting sample is without the ability that strengthens mice generation serum hemolysin.The dosage group of a test is positive, and the prompting sample can strengthen the mouse humoral immune function.
5.6 mice carbon clearance test result shows, under this experiment condition, each dosage group mice engulf tree planting A and solvent control class value relatively, all without statistical significant difference (P>0.05).Prompting sample five strengthens the effect that carbon is cleaned up ability.
5.7 engulfing chicken red blood cell experiment (dripping the sheet method) result, Turnover of Mouse Peritoneal Macrophages shows, under this experimental condition, the monocytes/macrophages phagocytic percentage of each sample and each dosage group mice and phagocytic index and solvent control class value compare, all without statistical significant difference (P>0.05).Prompting sample five strengthens the effect of Turnover of Mouse Peritoneal Macrophages phagocytic activity.Result of the test is all negative, and the prompting sample is without strengthening mouse monokaryon-macrophage phagocytic function.
5.8NK the cytoactive detection result shows, under this experimental condition, the NK cytoactive of each dosage group mice is all higher than the solvent control class value, and high dose group has statistical significant difference (P<0.05), the effect that the prompting sample has the NK cytoactive that strengthens mice.
Comprehensive above result of the test, according to health food enhancing immunity functional evaluation standard, 5 samples of prescription of the present invention all have the function of enhancing immunity.
Test example 2: the present invention is to improving the clinical efficacy of immune function of human body
The child: immunologic hypofunction, easy catching a cold, on average per month more than twice, or suffer from twice above patient of pneumonia in 1 year.
Elderly patients: suffer from multiple chronic disease, be diagnosed as the patient of syndrome of deficiency of lung qi.
2, method of administration and the course for the treatment of:
The preparation of the oral embodiment of the present invention 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5.Contrast: spirulina capsule, icariin capsule, Radix Ginseng+spirulina (1: 1) capsule; Spirulina+icariin (1: 1) capsule; Radix Ginseng+icariin (1: 1) capsule;
Adult: each 3 examples, every day 3 times.
Child below 6 years old: each 1, every day 2-3 time.
Child more than 6 years old: each 2, each 2-3 time.
Above patient all be take one month as a course for the treatment of, and it treats 1-3 the course for the treatment of.
3, observational technique:
Carry out blood, urine, just routine test and the heart, pulmonary function test, and observe: heating, aversion to cold, sniffle, pharyngeal symptom and systemic conditions and the temperature of having a medical check-up, pharyngeal tonsil, the picture of the tongue pulse condition, the variations such as fingerprint, carry out respectively therapeutic evaluation.
4, therapeutic evaluation
Table one prescription of the present invention improves the clinical observation of immune function of human body
| Compositions | Number of cases | Obviously improve | Improve | Invalid | Total improvement rate % |
| Embodiment 1 | 115 | 88 | 11 | 16 | 86.1 |
| Embodiment 2 | 108 | 85 | 9 | 14 | 87.0 |
| Embodiment 3 | 100 | 76 | 10 | 14 | 86.0 |
| Embodiment 4 | 101 | 80 | 8 | 13 | 87.1 |
| Embodiment 5 | 104 | 82 | 10 | 12 | 88.4 |
| Matched group (icariin capsule) | 45 | 17 | 6 | 22 | 51.1 |
| Matched group (spirulina capsule) | 48 | 19 | 9 | 20 | 58.3 |
| Matched group (Radix Ginseng+icariin) | 65 | 29 | 16 | 20 | 69.2 |
| Matched group (spirulina+Radix Ginseng) | 71 | 30 | 23 | 18 | 74.6 |
| Matched group (icariin+Radix Ginseng) | 82 | 34 | 24 | 14 | 70.7 |
Drug side effect of the present invention: period in a medicine small number of patients xerostomia, outside dry stool, all without any untoward reaction, drug withdrawal or decrement, mouthfeel, dry stool transference cure.
Test example 3: the impact test of the present invention on mouse anti-reflecting fatigue
Preparation of the present invention (embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5) is on mouse anti-reflecting fatigue impact test.90 of mices are divided into six groups at random, press the gastric infusion of dosage shown in table 2, and every day 1 time, continuous 10 days, Normal group and model group gave the equal-volume distilled water, and volume is 20ml/kg.And in the on-test first day.After the last administration 1 hour, animal is put into to the swimming groove of 15 ± 1 ℃, observe mice and put into water and be sink to the water-bed unable time of floating again for continuing swimming time.The results are shown in Table 2. from table 2 result, compositions of the present invention can obviously extend mice low temperature and continue swimming time.
The impact of table 2. preparation of the present invention on the mice swimming time
Result of the test shows, but preparation significant prolongation mice low temperature of the present invention continues swimming time.Show that the present invention has the ability of resisting fatigue to mice.
Test example 4: the clinical treatment of the present invention to the impotence patient
(1) clinical data
2009 are so far, and the inventor utilizes the preparation that embodiment 1, embodiment 2, embodiment 3 and embodiment 5 make to carry out clinical observation treatment to 541 routine impotence patients, wherein, and age 20-30 year, 103 examples; 31-40 year, 141 examples, 41-50 year, 126 examples, 51-60 year, 110 examples, more than 60 years old, 61 examples.Sexual impotence reason: psychic impotence 43 examples, sexual impotence 36 examples due to nephropathy, sexual impotence 34 examples due to hepatopathy, incretion sexual impotence 32 examples, sexual hypofunction (lowly) person 73 examples, psychogenic sexual impotence 26 examples, arteriosclerotic sexual impotence 22 examples, unknown cause sexual impotence 12 examples.Contrast medicament: icariin single dose capsule, Herba Epimedii+spirulina capsule agent (1: 1).
(2) Therapeutic Method
Compositions of the present invention, warm water is for oral administration, and three times on the one, each 3～6g, one after each meal.Calculate treatment time according to the conditions of patients weight, patients with mild is taken 3 months, and the severe case serve on 6 months.
(3) curative effect determinate standard
Cure: after the treatment phase, erection is greater than 90 degree, and success rate of sexual intercourse is more than or equal to 80%.
Produce effects: after the treatment phase, erection is greater than 90 degree, and success rate of sexual intercourse is more than or equal to 50%.
Effectively: after the treatment phase, the erection situation makes moderate progress,, success rate of sexual intercourse is more than or equal to 30%.
Invalid: before and after medication, indices is all without improving.
(4) clinical effectiveness
Clinical trial shows, the present invention has excellent therapeutic effect to impotence patient, and the patient's total effective rate that is less than 50 years old for the age reaches more than 90%, along with the increase therapeutic effect at age also decreases, but still has curative effect preferably with comparing.
Claims (6)
1. one kind has the collaborative Halth-care composition that improves human body immunity of organisms, antifatigue effect and kidney invigorating and YANG supporting, it is characterized in that being comprised of the raw material of following weight parts: Radix Ginseng 4-40 part, spirulina 7-40 part and Herba Epimedii 8-50 part.
2. according to the compositions of claim 1, it is characterized in that the Herba Epimedii in described compositions is icariin.
3. according to the compositions of claim 1, it is characterized in that the preparation that described compositions is peroral dosage form.
4. the compositions of claim 1, is characterized in that described compositions has the application in improving the immunity health medicine in preparation.
5. the compositions of claim 1, is characterized in that described compositions has the application in the anti-fatigue health-caring medicine in preparation.
6. the compositions of claim 1, is characterized in that described compositions has the application in the kidney invigorating and Yang strengthening function health medicine in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210122009.0A CN102631394B (en) | 2012-04-24 | 2012-04-24 | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210122009.0A CN102631394B (en) | 2012-04-24 | 2012-04-24 | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102631394A CN102631394A (en) | 2012-08-15 |
| CN102631394B true CN102631394B (en) | 2014-01-08 |
Family
ID=46616074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210122009.0A Active CN102631394B (en) | 2012-04-24 | 2012-04-24 | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102631394B (en) |
-
2012
- 2012-04-24 CN CN201210122009.0A patent/CN102631394B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102631394A (en) | 2012-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103027138B (en) | Tea for enlivening spleens and production method of tea | |
| CN106237075A (en) | A kind of have resisting fatigue and promote the food of attention effect, health product or pharmaceutical composition and its production and use | |
| CN102631494B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN104055935B (en) | It is a kind of to cooperate with the Chinese medicine composition for improving immunity | |
| CN1558768A (en) | A pharmaceutical composition made from Chinese traditional medicine and preparation method thereof | |
| CN101347543A (en) | Chinese medicine compound and preparation method thereof | |
| CN102631492B (en) | Chinese medicinal composition for improving immunity and resisting fatigue | |
| CN106075056A (en) | A kind of Ganoderma lucidum and preparation method improving immunity and improving gastrointestinal function | |
| CN102657730A (en) | Rhodiola rosea buccal preparations for resisting altitude reaction | |
| CN102631498B (en) | Chinese medicinal composition | |
| CN102631490B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN102631394B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN102631486B (en) | Health care composition | |
| CN102631506B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN106924581A (en) | It is a kind of to treat medicinal liquor of stomachache and preparation method thereof | |
| CN102631488B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN102631487B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN102631489B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN102274428B (en) | Pharmaceutical composition with effect on treating irritable bowel syndrome and preparation method and application thereof | |
| CN102120000B (en) | Composition of effective parts of traditional Chinese medicine preparation for resisting Coxsackie virus B and preparation method thereof | |
| CN104258034A (en) | Traditional Chinese medicine composition for boosting immunity | |
| CN102631496B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN102631393B (en) | Health care composition | |
| CN102631493B (en) | Health care composition | |
| CN102631389A (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220921 Address after: 224100 6, Jinfeng South Street, Dafeng District, Yancheng City, Jiangsu. Patentee after: Dafeng District Productivity Promotion Center, Yancheng City Address before: Ji Hongjinzhuan, Development Department, Jiangsu Huifeng Agrochemical Co., Ltd., South Head of Wanggang Zha, Dafeng City, Yancheng City, Jiangsu Province, 224100 Patentee before: Yang Cuihong |
|
| EE01 | Entry into force of recordation of patent licensing contract | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20120815 Assignee: JIANGSU HUIFENG BIO AGRICULTURE Co.,Ltd. Assignor: Dafeng District Productivity Promotion Center, Yancheng City Contract record no.: X2023980042603 Denomination of invention: Traditional Chinese medicine composition for enhancing immunity and anti fatigue Granted publication date: 20140108 License type: Common License Record date: 20230926 |
|
| EE01 | Entry into force of recordation of patent licensing contract | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20120815 Assignee: DAFENG HEGNO PHARMACEUTICALS Co.,Ltd. Assignor: Dafeng District Productivity Promotion Center, Yancheng City Contract record no.: X2023980045165 Denomination of invention: Traditional Chinese medicine composition for enhancing immunity and anti fatigue Granted publication date: 20140108 License type: Common License Record date: 20231102 Application publication date: 20120815 Assignee: YANCHENG DESANO PHARMACEUTICAL Co.,Ltd. Assignor: Dafeng District Productivity Promotion Center, Yancheng City Contract record no.: X2023980045163 Denomination of invention: Traditional Chinese medicine composition for enhancing immunity and anti fatigue Granted publication date: 20140108 License type: Common License Record date: 20231102 Application publication date: 20120815 Assignee: JIANGSU BROTHER VITAMINS Co.,Ltd. Assignor: Dafeng District Productivity Promotion Center, Yancheng City Contract record no.: X2023980045158 Denomination of invention: Traditional Chinese medicine composition for enhancing immunity and anti fatigue Granted publication date: 20140108 License type: Common License Record date: 20231102 Application publication date: 20120815 Assignee: JIANGSU CHIA TAI FENGHAI PHARMACEUTICAL Co.,Ltd. Assignor: Dafeng District Productivity Promotion Center, Yancheng City Contract record no.: X2023980045154 Denomination of invention: Traditional Chinese medicine composition for enhancing immunity and anti fatigue Granted publication date: 20140108 License type: Common License Record date: 20231102 |