CN105012686B - A kind of pharmaceutical preparation and preparation method thereof for treating Shelled Turtle Trionyx Sinensis stress disease - Google Patents
A kind of pharmaceutical preparation and preparation method thereof for treating Shelled Turtle Trionyx Sinensis stress disease Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical preparations and preparation method thereof for treating Shelled Turtle Trionyx Sinensis stress disease, it is the medicinal powder made of the Chinese medicine material of following weight percentage, uncaria 7~13%, corydalis tuber 7~13%, jujube kernel 5~11%, Radix Salviae Miltiorrhizae 5~11%, radix bupleuri 5~11%, Radix Rehmanniae 5~11%, motherwort 2~8%, medical stone 2~8%, sealwort 5~11%, Radix Astragali 5~11%, Herba Epimedii 5~11%, Schisandra chinensis 5~11%, Radix Glycyrrhizae 2~8%, vitamin C 0.5~1.5%, the sum of each component are 100%；The preparation method of the pharmaceutical preparation is to be pulverized after weighing vitamin C by weight percentage, is mixed after weighing each Chinese medicine by weight percentage, crushed 80 mesh sieve, then mixed with vitamin c powder after being dried to obtain the final product.A kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease of the present invention has the characteristics that therapeutic effect is good, drug residue free to treatment Shelled Turtle Trionyx Sinensis stress disease.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparations, more specifically more particularly to a kind of Shelled Turtle Trionyx Sinensis stress disease for the treatment of
Pharmaceutical preparation, the invention further relates to the preparation methods of this kind of pharmaceutical preparation.
Background technology
In Shelled Turtle Trionyx Sinensis breeding process, when certain environment variation occurs for Shelled Turtle Trionyx Sinensis sense organ to the external world, Shelled Turtle Trionyx Sinensis body pair
Environmental stimuli will produce corresponding specific variations, which is that Shelled Turtle Trionyx Sinensis attempts to adapt to the variation of internal and external environment and generate
Non-specificity variation.Shelled Turtle Trionyx Sinensis stress disease caused by so-called " environment-stress " factor is exactly Shelled Turtle Trionyx Sinensis by external environment
The nonspecific reaction that the stimulation of variation generates.Usual Shelled Turtle Trionyx Sinensis stress disease is shown as：In the production item of intensive culture
Under part, especially Raised turtle when such as there is high temperature, high density, the ecological ragime of high pollution, or when Shelled Turtle Trionyx Sinensis soft-shelled turtle faces
The stress factor for the environment that may occur in natural life area far beyond it, physiology and the aspects such as immune, is easy production
Raw stress disease.Such as Shelled Turtle Trionyx Sinensis can have dizzy spells under conditions of high temperature, high pollution and severe depletion of oxygen, and stress reaction is strong,
It often shows as emerging, head is rocked on the water surface, is far from being tranquil, and for a long time, just will produce neurotoxic, forelimb occurs
It is bent the symptom that cannot be stretched, the death rate is 20% or more.Stress disease makes that the production performance of Shelled Turtle Trionyx Sinensis declines, ingesting subtracts
It is few, larger detrimental effect is generated to feed conversion rate, the speed of growth, survival rate etc..Traditional treatment Shelled Turtle Trionyx Sinensis irritability disease
Vitamin C is mainly taken when sick, and it is undesirable singly to carry out therapeutic effect using such drug.Therefore, a kind of drug system how is found
Shelled Turtle Trionyx Sinensis stress disease is treated in agent, is kept its therapeutic effect more preferable, and drug residue free, is become urgently to be resolved hurrily ask
Topic.
Invention content
The purpose of the present invention is to provide the pharmaceutical preparations for the treatment of Shelled Turtle Trionyx Sinensis stress disease, this kind of pharmaceutical preparation is to treatment
Shelled Turtle Trionyx Sinensis stress disease has the characteristics that therapeutic effect is good, drug residue free.
It is a further object of the present invention to provide a kind of preparation methods of said medicine preparation.
The previous technical solution of the present invention is as follows：
A kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease, it is made of the medicine material of following weight percentage
Medicinal powder, uncaria 7~13%, corydalis tuber 7~13%, jujube kernel 5~11%, Radix Salviae Miltiorrhizae 5~11%, radix bupleuri 5~11%, Radix Rehmanniae 5~
11%, motherwort 2~8%, medical stone 2~8%, sealwort 5~11%, Radix Astragali 5~11%, Herba Epimedii 5~11%, Schisandra chinensis 5
~11%, Radix Glycyrrhizae 2~8%, vitamin C 0.5~1.5%, the sum of each component are 100%.
Further, the drug weight degree is：Uncaria 10%, corydalis tuber 10%, jujube kernel 8%, Radix Salviae Miltiorrhizae
8%, radix bupleuri 8%, Radix Rehmanniae 8%, motherwort 5%, medical stone 5%, sealwort 8%, Radix Astragali 8%, Herba Epimedii 8%, Schisandra chinensis 8%,
Radix Glycyrrhizae 5%, vitamin C 1%.
Further, the medicinal powder granularity is less than 80 mesh.
The latter technique scheme of the present invention is as follows：
A kind of preparation method of pharmaceutical preparation that treating Shelled Turtle Trionyx Sinensis stress disease, including following preparation processes：
(1) vitamin C medicinal powder is pulverized into after weighing vitamin C by weight percentage；
(2) precentagewise weighs uncaria, corydalis tuber, jujube kernel, Radix Salviae Miltiorrhizae, radix bupleuri, Radix Rehmanniae, motherwort, medical stone, sealwort, Huang
It is mixed after these Chinese medicine materials of stilbene, Herba Epimedii, Schisandra chinensis and Radix Glycyrrhizae；
(3) mixed Chinese medicine is crushed into processing；
(4) traditional Chinese medicine powder after crushing is crossed into 80 mesh sieve；
(5) traditional Chinese medicine powder after screening is subjected to microwave drying, then after mixing with vitamin C medicinal powder to obtain the final product.
Further, in step (5), drying time is 20~40 minutes.
Compared with prior art, the device have the advantages that being：
A kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease of the present invention, other than vitamin C, remaining is all selected
Chinese medicine material, the not drug resistance, drug resistance of chemical agent and poisoning remain.Uncaria in preparation has The flat liver of heat-clearing, relieves dizziness, high fever, infantile convulsions, epilepsy, etc.
The effect of arresting convulsion；Corydalis tuber is warm-natured, acrid flavour is bitter, has effects that promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain；Jujube kernel sugariness is flat, has and supports
The effect of liver, calming heart, tranquilizing the mind, arrest sweating；Radix Salviae Miltiorrhizae energy promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness that clears away heart-fire, nourishing blood and tranquilization；Bavin
Recklessly there is inducing diaphoresis to bring down a fever, soothing liver-qi stagnation the effect of；Radix Rehmanniae has effects that clearing heat and cooling blood；Motherwort can invigorate blood circulation；Medical stone contains more
Kind minerals, there is oxygen lack resistant function；Sealwort has the effect of boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing；What is contained in Herba Epimedii is excessive
Sheep leaves of pulse plants glycosides, can promote hematopoiesis function, immune function and bone metabolism, have the effects that antibacterial, antiviral, anti-inflammatory；Schisandra chinensis energy
Nourishing generate fluid, kidney tonifying nourishing heart, convergence astringent method, build up one's resistance to disease；Radix Astragali is tonifying Qi good medicine, resistance building.By this
For the medicament of formula for treating Shelled Turtle Trionyx Sinensis stress disease, therapeutic effect is good, and the Shelled Turtle Trionyx Sinensis of morbidity is generally even fed to 3~4 days just
It can cure.
A kind of preparation method of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease of the present invention, weighs by weight percentage
Vitamin C medicinal powder is pulverized into after vitamin C, is mixed after weighing various Chinese medicines by weight percentage, then by mixed traditional Chinese medicine powder
It is broken and cross 80 mesh sieve, microwave drying again with vitamin C medicinal powder after mixing to obtain the final product, when which decocts in Chinese medicine
Active ingredient can be preferably dissolved into water, the sick Shelled Turtle Trionyx Sinensis of feeding after feed is mixed with liquid, facilitate its edible suction
It receives.
Specific implementation mode
With reference to specific embodiment, technical scheme of the present invention is described in further detail, but is not constituted to this
Any restrictions of invention.
Embodiment 1
A kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease, each component weight percent are：Uncaria 7%, corydalis tuber
13%, jujube kernel 5%, Radix Salviae Miltiorrhizae 11%, radix bupleuri 5%, Radix Rehmanniae 11%, motherwort 2%, medical stone 8%, sealwort 5%, Radix Astragali 11%,
Herba Epimedii 5%, Schisandra chinensis 11%, Radix Glycyrrhizae 5%, vitamin C 1%.
The preparation method of the pharmaceutical preparation of the present invention, includes the following steps：
(1) vitamin C medicinal powder is pulverized into after weighing vitamin C by weight percentage.Select common tablet vitamin C i.e.
Can, and this vitamin C tablet easily pulverizes, and is readily soluble in water, needs not move through pulverization process.
(2) precentagewise weighs uncaria, corydalis tuber, jujube kernel, Radix Salviae Miltiorrhizae, radix bupleuri, Radix Rehmanniae, motherwort, medical stone, sealwort, Huang
It is mixed after these Chinese medicine materials of stilbene, Herba Epimedii, Schisandra chinensis and Radix Glycyrrhizae.The medicament that this few taste medicinal material collocation is prepared is for controlling
Shelled Turtle Trionyx Sinensis stress disease is treated, keeps therapeutic effect good.
(3) mixed Chinese medicine is crushed into processing, each Chinese medicine mixed effect after crushing is more preferable.In mixed
Medicine breaks into pulvis, and active ingredient is preferably dissolved in water when medicinal powder being enable to add water to cook, more preferable so as to the Shelled Turtle Trionyx Sinensis of illness
Absorption.
(4) traditional Chinese medicine powder after crushing is crossed into 80 mesh sieve, to ensure that the particle of traditional Chinese medicine powder is less than 80 mesh.
(5) traditional Chinese medicine powder after screening is subjected to microwave drying, then after mixing with vitamin C medicinal powder to obtain the final product.Wherein, it does
The dry time is 20~40 minutes.Microwave drying carries out usually in microwave tunnel, can control microwave intensity appropriate, reaches fast
The dry purpose of rapid-curing cutback.By the way that Chinese medicine is carried out microwave drying treatment, make Chinese medicine is drier to facilitate storage and microwave is also carried and killed
Bacterium acts on, and in addition killing bacteria can need not be increased sterilization steps.
A kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease of the present invention, other than vitamin C, remaining is all selected
Chinese medicine material, the not drug resistance, drug resistance of chemical agent and poisoning remain.Wherein, the corydalis tuber in medicament, Radix Salviae Miltiorrhizae and benefit are female
Grass has effects that promoting blood circulation, the uncaria, jujube kernel in medicament and the soothing the liver soothing the liver of radix bupleuri energy, sealwort, Radix Astragali, Herba Epimedii and Schisandra chinensis energy
Immunity is improved, medical stone plays the role of anti anoxia, by the medicament of this formula for treating Shelled Turtle Trionyx Sinensis stress disease, treatment effect
Fruit is good, and generally even feeding the Shelled Turtle Trionyx Sinensis of morbidity 3~4 days can cure.
Application method：When finding that the Shelled Turtle Trionyx Sinensis in soft-shelled turtle pond suffers from stress disease, claim 80g as a standard part in medicinal powder,
By the Shelled Turtle Trionyx Sinensis of every illness every time by a kind of one standard part medicine of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease of the present invention
Powder is put in marmite, is added in 150ml water after being cooked by slow fire 2 hours, and taking liquid, which removes slag, to be cooled, and is mixed into 4% Chinese trionyx sinensis feed and is stirred
It feeds after mixing uniformly, once in the morning and once at night, cures within 3~4 days.
Embodiment 2
A kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease, each component weight percent are：Uncaria 10%, corydalis tuber
10%, jujube kernel 8%, Radix Salviae Miltiorrhizae 8%, radix bupleuri 8%, Radix Rehmanniae 8%, motherwort 5%, medical stone 5%, sealwort 8%, Radix Astragali 8%, excessive sheep
The leaves of pulse plants 8%, Schisandra chinensis 8%, Radix Glycyrrhizae 5%, vitamin C 1%.
Preparation method and application method are same as Example 1.
Embodiment 3
A kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease, each component weight percent are：Uncaria 13%, corydalis tuber
7%, jujube kernel 11%, Radix Salviae Miltiorrhizae 5%, radix bupleuri 11%, Radix Rehmanniae 5%, motherwort 8%, medical stone 2%, sealwort 11%, Radix Astragali 5%, excessive
The sheep leaves of pulse plants 11%, Schisandra chinensis 5%, Radix Glycyrrhizae 5%, vitamin C 1%.
Preparation method and application method are same as Example 1.
Embodiment 4
A kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease, each component weight percent are：Uncaria 8%, corydalis tuber
12%, jujube kernel 6%, Radix Salviae Miltiorrhizae 10%, radix bupleuri 6%, Radix Rehmanniae 10%, motherwort 3%, medical stone 7%, sealwort 6%, Radix Astragali 10%,
Herba Epimedii 6%, Schisandra chinensis 10%, Radix Glycyrrhizae 4.5%, vitamin C 1.5%.
Preparation method and application method are same as Example 1.
Embodiment 5
A kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease, each component weight percent are：Uncaria 12%, corydalis tuber
8%, jujube kernel 7%, Radix Salviae Miltiorrhizae 9%, radix bupleuri 9%, Radix Rehmanniae 7%, motherwort 7%, medical stone 3%, sealwort 6%, Radix Astragali 10%, excessive sheep
The leaves of pulse plants 9%, Schisandra chinensis 7%, Radix Glycyrrhizae 5.5%, vitamin C 0.5%.
Preparation method and application method are same as Example 1.
Contrast test
Test site is selected in the progress of Wuzhou Jingtai farm of Yang Bie Specialty Co-operative Organizations.After in July, 2013, with temperature
It increasing, water level reaches 28~30 DEG C in Trionyx Sinensis pond, and the Trionyx Sinensis part in soft-shelled turtle pond shows to have dizzy spells successively,
It often shows as emerging, head is rocked on the water surface, is far from being tranquil, and checks its body, it is found that whole body body surface is intact, no spot
Point, no ulcer tentatively conclude that they suffer from stress disease.
Control method
Experiment is essentially identical by two specifications, and using identical water system at soft-shelled turtle pond, the Shelled Turtle Trionyx Sinensis quantity of cultivation is identical
And also essentially identical soft-shelled turtle pond is set as experiment into soft-shelled turtle pond to disease condition, and it is test group that No. 1 soft-shelled turtle pond, which is arranged, and No. 2 soft-shelled turtle ponds are pair
According to group.In on-test, respectively record 1, No. 2 soft-shelled turtle pond in illness at soft-shelled turtle number.One kind of the present invention is used in No. 1 soft-shelled turtle pond
The Chinese medicine preparation for the treatment of Shelled Turtle Trionyx Sinensis stress disease is treated, and takes 1 standard part medicinal powder to be put in sand by every Shelled Turtle Trionyx Sinensis in soft-shelled turtle pond
In pot, it is added in 150ml water by every 1 standard part medicinal powder after being cooked by slow fire 2 hours, taking liquid, which removes slag, to be cooled, and 4% Shelled Turtle Trionyx Sinensis is mixed into
Feed is fed after stirring evenly, once in the morning and once at night, after being used in conjunction 3 days, the case where observing and recording Trionyx Sinensis in No. 1 soft-shelled turtle pond.2
Number soft-shelled turtle pond is treated using vitamin C tablet merely, and vitamin C medicine is weighed by per kilogram feed addition 3~4g of vitamin C
Vitamin C medicinal powder is pulverized into after piece, is put into after being stirred evenly in feed and is fed, continuous 7 days, in observing and recording in No. 1 soft-shelled turtle pond
The case where magnificent soft-shelled turtle is at soft-shelled turtle.The Shelled Turtle Trionyx Sinensis treatment results comparable situation in 1, No. 2 soft-shelled turtle pond is as follows：
Results contrast after experimental group and control group medication
According to data analysis in results contrast table after test group and contrast groups medicine, the sick soft-shelled turtle healing time in No. 1 soft-shelled turtle pond is short
Sick soft-shelled turtle healing time in No. 2 soft-shelled turtle ponds, the sick soft-shelled turtle in No. 1 soft-shelled turtle pond after 3 days substantially the state of mind, ingest and live just
Often, whole illness have been cured at soft-shelled turtle, and the most of spirit after 3 days of sick soft-shelled turtle in No. 2 soft-shelled turtle ponds improves, increase of ingesting, at soft-shelled turtle major part
Water-bed rest is sneaked into, most of illness improves at soft-shelled turtle；Sick soft-shelled turtle in No. 2 soft-shelled turtle ponds is all cured after treating 7 days, No. 1 soft-shelled turtle pond
Do not find new illness at soft-shelled turtle.In summary comparative analysis data obtain, stress using a kind of Shelled Turtle Trionyx Sinensis for the treatment of of the present invention
The Chinese medicine preparation of property disease is treated, and therapeutic effect is more preferable.
Other than vitamin C, remaining is all selected a kind of Chinese medicine preparation for treating Shelled Turtle Trionyx Sinensis stress disease of the present invention
Chinese medicine material, the drug resistance, drug resistance of chemical agent, will not be such that drug is remained on the body of Shelled Turtle Trionyx Sinensis.
The foregoing is merely presently preferred embodiments of the present invention, it is all within the scope of the spirit and principles in the present invention made by it is any
Modifications, equivalent substitutions and improvements etc., should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease, which is characterized in that it is by the medicine of following weight percentage
Medicinal powder made of raw material：Uncaria 7~13%, corydalis tuber 7~13%, jujube kernel 5~11%, Radix Salviae Miltiorrhizae 5~11%, radix bupleuri 5~
11%, Radix Rehmanniae 5~11%, motherwort 2~8%, medical stone 2~8%, sealwort 5~11%, Radix Astragali 5~11%, Herba Epimedii 5~
11%, Schisandra chinensis 5~11%, Radix Glycyrrhizae 2~8%, vitamin C 0.5~1.5%, the sum of each component are 100%.
2. a kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease according to claim 1, which is characterized in that described
Drug weight degree is：Uncaria 10%, corydalis tuber 10%, jujube kernel 8%, Radix Salviae Miltiorrhizae 8%, radix bupleuri 8%, Radix Rehmanniae 8%, benefit are female
Grass 5%, medical stone 5%, sealwort 8%, Radix Astragali 8%, Herba Epimedii 8%, Schisandra chinensis 8%, Radix Glycyrrhizae 5%, vitamin C 1%.
3. a kind of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease according to claim 1, which is characterized in that described
Medicinal powder granularity is less than 80 mesh.
4. a kind of preparation method of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease as claimed in claim 1 or 2, feature exist
In, including following preparation processes：
(1) vitamin C medicinal powder is pulverized into after weighing vitamin C by weight percentage；
(2) precentagewise weighs uncaria, corydalis tuber, jujube kernel, Radix Salviae Miltiorrhizae, radix bupleuri, Radix Rehmanniae, motherwort, medical stone, sealwort, Radix Astragali, excessive
It is mixed after these Chinese medicine materials of the sheep leaves of pulse plants, Schisandra chinensis and Radix Glycyrrhizae；
(3) mixed Chinese medicine is crushed into processing；
(4) traditional Chinese medicine powder after crushing is crossed into 80 mesh sieve；
(5) traditional Chinese medicine powder after screening is subjected to microwave drying, then after mixing with vitamin C medicinal powder to obtain the final product.
5. a kind of preparation method of pharmaceutical preparation for treating Shelled Turtle Trionyx Sinensis stress disease according to claim 4, feature
It is, in step (5), drying time is 20~40 minutes.
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| CN107484894A (en) * | 2017-09-20 | 2017-12-19 | 江西省水产科学研究所 | A kind of Shelled Turtle Trionyx Sinensis resisting stress Chinese herbal feed using hooked uncaria tea as base-material |
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| 抗蛋鸡热应激添加剂的研究进展;刘凤华等;《国外畜牧科技》;19970630;第24卷(第2期);第17-20页，尤其是第18页右栏第2段、4中草药抗热应激添加剂 * |
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