CN107737224A - A kind of Chinese medicine compound prescription for treating liver cancer and preparation method thereof - Google Patents
A kind of Chinese medicine compound prescription for treating liver cancer and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to technical field of Chinese medicine, specifically a kind of Chinese medicine compound prescription for treating liver cancer and preparation method thereof.The Chinese medicine compound prescription is made up of following raw material：20 ~ 30 parts of corydalis tuber, 15 ~ 25 parts of plantain seed, 15 ~ 25 parts of Chinese actinidia root, 10 ~ 20 parts of Paris polyphylla, 15 ~ 25 parts of Selaginella pulvinata, 10 ~ 20 parts of wilsonii, 5 ~ 10 parts of radix glycyrrhizae, 10 ~ 15 parts of the red sage root, 10 ~ 15 parts of folium isatidis, 10 ~ 15 parts of the fruit of Chinese wolfberry.Chinese medicine is made it mutually cooperate with by the present invention with certain proportion allotment, play altogether promoting blood circulation and removing blood stasis, clearing damp resolving sputum, softening and resolving hard mass, it is clearing heat and detoxicating the effect of, and ill symptomses such as Neuroleptic Leukocytopenia, decrease of platelet and systemic pain caused by corydalis tuber, plantain seed, Chinese actinidia root, Paris polyphylla, Selaginella pulvinata can effectively be alleviated after jaundice caused by liver cancer, ascites and tumor chemoradiotherapy.
Description
Technical field
The present invention relates to technical field of Chinese medicine, specifically a kind of Chinese medicine compound prescription for treating liver cancer and preparation method thereof.
Background technology
Cancer is a kind of serious threat human health and the common disease and frequently-occurring disease of life, is countries in the world medical science neck
Important scientific research task in domain, there is no satisfied remedy measures at present.And liver cancer is one of most common malignant tumour in the whole world,
It refers to that the malignant tumour for betiding liver, including two kinds of primary carcinoma of liver and metastatic hepatic carcinoma, the liver cancer of the daily theory of people refer to
It is mostly be primary carcinoma of liver.Primary carcinoma of liver is clinically one of most common malignant tumour, every according to recent statistics, the whole world
Nian Xinfa liver cancer patients about 600,000, the onset of liver cancer rate and the death rate for occupying the 5th China of malignant tumour are accounted in tumour
Second.Clinical treatment liver cancer mainly includes：First, using surgical excision, removal lesion tissue, prevent cancer cell from spreading
；Second, chemotherapy or radiotherapy are used, to kill cancer cell；Third, use drug therapy.This several method can all produce very big to human body
Burden, the pain of patient is added using the method for surgery excision, hinders its vigour, expense is huge.Drug therapy mainly makes
With Treated with Chemotherapeutic Drugs thing, which is still current clinical primary treatment regimen, and this mode is to the immune of body, hemopoietic system
And its damage of each histoorgan of whole body is very big, systemic organs of the patient finally mostly caused by chemotherapy, which die of exhaustion, to die, and finds
The problem of effective treatment method is current liver cancer treatment urgent need to resolve.
Traditional Chinese medicine because it is tired, clearing heat and detoxicating with promoting blood circulationization, strengthen the body resistance to consolidate the constitution and other effects play antitumor action, may act on
Multiple links of tumorigenesis.Chinese medicine is suppressing killing tumor cell, improves symptom and is mitigating chemicotherapy bad anti-
Patient survival etc., should be extended to play a significant role.But effective Chinese medicine compound prescription for the treatment of liver cancer is also very rare at present.
At present, many patients often excessively pay attention to doctor trained in Western medicine liver cancer treatment, and doctor trained in Western medicine need using the means of chemicotherapy come
Such disease is treated, its caused side effect causes body and many influences of psychology on patient.Chinese medicine is as the rare of China
Treasured, the effect of showing to treat liver cancer class disease with Mutiple Targets multi-angle through modern study, and with caused by reduction chemicotherapy
Side effect, extend the sufferer life-span.But due to Chinese medicine because taste is poor, mouthfeel is bad, causes most people to be unwilling to take.
The content of the invention
Present invention aims to overcome that the defects of problem above, there is provided in a kind of relatively fast assisting in treating liver cancer that works
Medicine compound and preparation method thereof.
For achieving the above object, the present invention adopts the following technical scheme that：
A kind of Chinese medicine compound prescription for treating liver cancer, it is made up of following raw material：20 ~ 30 parts of corydalis tuber, plantain seed 15 ~ 25
Part, 15 ~ 25 parts of Chinese actinidia root, 10 ~ 20 parts of Paris polyphylla, 15 ~ 25 parts of Selaginella pulvinata, 10 ~ 20 parts of wilsonii, 5 ~ 10 parts of radix glycyrrhizae,
10 ~ 15 parts of the red sage root, 10 ~ 15 parts of folium isatidis, 10 ~ 15 parts of the fruit of Chinese wolfberry.
The preparation method of the Chinese medicine compound prescription of above-mentioned treatment liver cancer, comprises the following steps：
(1) by corydalis tuber, plantain seed, Chinese actinidia root, Paris polyphylla, Selaginella pulvinata, wilsonii, radix glycyrrhizae, the red sage root, folium isatidis, Chinese holly
Matrimony vine is ground into fritter after being rinsed with clear water, add 75% ethanol and soak 8 ~ 12 hours；
(2) extract：Heating and refluxing extraction 3 times at 90 DEG C by the medicinal material after immersion, extraction 2 hours, are filtered after extraction every time every time
Go out extract solution, and rejoin 75% ethanol and extracted；After 3rd extraction, extract solution is filtered out, water is added in the remaining dregs of a decoction,
Continue heat extraction 3 times at 90 DEG C, every time extraction 2 hours；Merge alcohol extract and aqueous extract respectively；
(3) medicinal extract is concentrated into after filtering the aqueous extract in step (2) and alcohol extract respectively, in vacuum freeze drier
After drying, two kinds of extracts are mixed and produced.
The preparation method of the Chinese medicine compound prescription of above-mentioned treatment liver cancer, the middle amount for adding 75% ethanol of step (1) and medicinal material total amount
Than for 9.5mL: 1g.
The preparation method of the Chinese medicine compound prescription of above-mentioned treatment liver cancer, the amount that 75% ethanol is rejoined in step (2) is step
(1) 0.8 times of the amount of 75% ethanol is added in, the ratio of the amount and medicinal material total amount that add water is 10mL: 1g.
The preparation method of the Chinese medicine compound prescription of above-mentioned treatment liver cancer, it is filtered into step (3) and is filtered under diminished pressure.
A kind of pharmaceutical preparation containing above-mentioned treatment liver cancer Chinese medicine compound prescription, the Chinese medicine compound prescription and pharmaceutically acceptable auxiliary material
The formulation in any pharmacy is made.Pharmaceutically acceptable auxiliary material be drug field in above-mentioned formulation is prepared it is conventional with
General auxiliary material, and be made according to this area customary preparation methods.
The Chinese medicine compound prescription of above-mentioned treatment liver cancer is applied in liver-cancer medicine is treated.
The drug effect of raw material used in the present invention：
The red sage root：Bitter.Cold nature.The thoughts of returning home, pericardium, Liver Channel.Calm the nerves with promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness
Effect.It is usually used in treating irregular menstruation, closed dysmenorrhea, postpartum stasis of blood, blood stasis is pained, epigastric pain, traumatic injury , Disorder lumps in the abdomen
The symptoms such as accumulation, rheumatic Bi syndrome, sore, carbuncle and painful swelling, hot carbuncle agitation, coma, palpitaition, insomnia.
Selaginella pulvinata：Taste micro-sweet.It is mild-natured.Return liver, the heart channel of Hang-Shaoyin.With reducing fever and causing diuresis, activating blood circulation and reducing swelling and other effects.It is usually used in treating
Amenorrhea, abdominal mass, traumatic injury, stomachache, asthma, spit blood, the symptom such as have blood in stool.
Folium isatidis：It is bitter, cold in nature.The thoughts of returning home, stomach.The effect of with clearing heat and detoxicating, cool blood, ecchymose removing.It is usually used in heat to join the army
Blood, febrile virulent maculae, the treatment of larynx numbness aphtha, mumps, erysipelas.
Plantain seed：Sweet, cold nature.Return liver, kidney, lung, small intestinl channel.With inducing diuresis for treating strangurtia, excreting dampness antidiarrheal, improving eyesight, eliminating the phlegm
The effect of.It is usually used in stranguria, oedema, diarrhea, red eye, swell pain, mesh eyeball is dim-sighted, ocular, the treatment of phlegm-heat cough.
Corydalis tuber：It is acrid flavour, hardship, warm-natured.The thoughts of returning home, liver, the spleen channel.The effect of with blood-activating and qi-promoting, analgesic.It is usually used in stagnation of the circulation of vital energy blood
The treatment of all pains of the stasis of blood.
Radix glycyrrhizae：It is sweet.It is mild-natured.The thoughts of returning home, lung, spleen, stomach.It is all with clearing heat and detoxicating, cough-relieving apophlegmatic, tonifying spleen and stomach, mediation
The effect of medicine.
Wilsonii：It is sweet, slight bitter, warm-natured.Returns spleen, lung, the heart, kidney channel.The effect of with replenishing qi to invigorate the spleen, tonifying the kidney to relieve mental strain.Often
For syndrome of qi deficiency of spleen and lung, kidney deficiency soreness of waist and knee joint, deficiency of both the heart and spleen, the treatment of insomnia forgetfulness.
Chinese actinidia root：It is sour, puckery, cool in nature.With the effect of clearing heat and detoxicating, dispelling wind and eliminating dampness, diuresis is stopped blooding.It is usually used in being used for wind
Wet ostalgia, and the treatment of the disease such as jaundice.
Paris polyphylla：It is bitter, cold in nature.The thoughts of returning home, liver, lung channel.With clearing heat and detoxicating, swelling and pain relieving.It is usually used in being used to flow
Row encephalitis B, stomachache, appendicitis, scrofula, tonsillitis, parotitis, mastitis, poisonous snake, insect-bite, sore
The treatment of pyogenic infections.
The fruit of Chinese wolfberry：It is sweet, mild-natured.Return liver warp；Kidney channel；Lung channel.The effect of with nourishing the liver, nourshing kidney, moistening lung.It is usually used in
Caused by liver and kidney deficiency, have a dizzy spell, be visual one clear, soreness and weakness of waist and knees, impotence and seminal emission, cough due to consumptive disease, quenching one's thirst and draw drink, blood-enriching tranquillizing, promote the production of body fluid
Quench the thirst, moisten the lung and relieve the cough.
Compared with prior art, the invention has the advantages that：Chinese medicine is made it by the present invention with certain proportion allotment
Mutually collaboration, play altogether promoting blood circulation and removing blood stasis, clearing damp resolving sputum, softening and resolving hard mass, it is clearing heat and detoxicating the effect of, and corydalis tuber, plantain seed, Chinese gooseberry
Root, Paris polyphylla, Selaginella pulvinata can effectively be alleviated caused by after jaundice caused by liver cancer, ascites and tumor chemoradiotherapy
The ill symptomses such as Neuroleptic Leukocytopenia, decrease of platelet and systemic pain；In addition wilsonii, radix glycyrrhizae, the red sage root, folium isatidis, matrimony vine
Son can reconcile body as weak body tonifying primordial Qi while also enhance immunity.Chinese medicine compound prescription of the present invention prepares simple, original
Material is easy to get, and suitable for popular use, has good application prospect.The present invention is effective to its by way of being extracted to Chinese medicine thermal
Composition is extracted, and any formulation can be made, and can so be covered the bad smell of medicine institute's band in itself, can also be improved
Medicine stability and bioavilability, being advantageous to it has the absorption of composition.
Embodiment
The present invention is described in further detail with reference to instantiation：
Embodiment 1
A kind of Chinese medicine compound prescription for treating liver cancer, is made up of following raw material：Corydalis tuber 20g, the g of plantain seed 15, Chinese actinidia root 15 g, seven
Ye Yizhi spends 10 g, the g of Selaginella pulvinata 15, the g of wilsonii 10, the g of radix glycyrrhizae 5, the g of the red sage root 10, the g of folium isatidis 10, the g of the fruit of Chinese wolfberry 10.
The preparation method of above-mentioned Chinese medicine compound prescription, comprises the following steps：
(1) proportioning is pressed by corydalis tuber, plantain seed, Chinese actinidia root, Paris polyphylla, Selaginella pulvinata, wilsonii, radix glycyrrhizae, the red sage root, smalt
Leaf, the fruit of Chinese wolfberry are ground into fritter after being rinsed with clear water, add 75% ethanol and soak 8 hours, and amount and the medicinal material for adding 75% ethanol are total
The ratio of amount is 9.5mL: 1g；
(2) heating and refluxing extraction 3 times at 90 DEG C by the medicinal material after immersion, extraction 2 hours, filter out after extraction carry every time every time
Liquid is taken, and rejoins 75% ethanol and is extracted, the amount for rejoining 75% ethanol is the amount of 75% ethanol of addition in step (1)
0.8 times,；After 3rd extraction, extract solution is filtered out, water is added in the remaining dregs of a decoction, the ratio of the amount and medicinal material total amount that add water is
10mL: 1g, continue heat extraction 3 times at 90 DEG C, every time extraction 2 hours；Merge alcohol extract and aqueous extract respectively；
(3) Aqueous extracts in step (2) and alcohol extract are filtered under diminished pressure respectively, filter out large granular impurity, be concentrated into medicinal extract, true
Dried in vacuum freecing-dry machine after removing moisture, two kinds of extracts are mixed, be fitted into capsule shells and the capsule of 0.25g/ grains is made
Grain.
Instructions of taking：Orally, 3 times a day, 2 tablets each time.
Embodiment 2
A kind of Chinese medicine compound prescription for treating liver cancer, is made up of following raw material：The g of corydalis tuber 25, the g of plantain seed 20, Chinese actinidia root 20 g, seven
Ye Yizhi spends 15 g, the g of Selaginella pulvinata 20, the g of wilsonii 15, the g of radix glycyrrhizae 8, the g of the red sage root 12, the g of folium isatidis 12, the g of the fruit of Chinese wolfberry 12.
(1) by proportioning by corydalis tuber, plantain seed, Chinese actinidia root, Paris polyphylla, Selaginella pulvinata, wilsonii, radix glycyrrhizae, the red sage root,
Folium isatidis, the fruit of Chinese wolfberry are ground into fritter after being rinsed with clear water, add 75% ethanol and soak 10 hours, add the amount and medicine of 75% ethanol
The ratio of material total amount is 9.5mL: 1g；
(2) heating and refluxing extraction 3 times at 90 DEG C by the medicinal material after immersion, extraction 2 hours, filter out after extraction carry every time every time
Liquid is taken, and rejoins 75% ethanol and is extracted, the amount for rejoining 75% ethanol is the amount of 75% ethanol of addition in step (1)
0.8 times,；After 3rd extraction, extract solution is filtered out, water is added in the remaining dregs of a decoction, the ratio of the amount and medicinal material total amount that add water is
10mL: 1g, continue heat extraction 3 times at 90 DEG C, every time extraction 2 hours；Merge alcohol extract and aqueous extract respectively；
(3) Aqueous extracts in step (2) and alcohol extract are filtered under diminished pressure respectively, filter out large granular impurity, be concentrated into medicinal extract, true
Dried in vacuum freecing-dry machine after removing moisture, two kinds of extracts are mixed, tablet, every 0.25g is made in tabletting.
Instructions of taking：Orally, 3 times a day, 2 tablets once.
Embodiment 3
A kind of Chinese medicine compound prescription for treating liver cancer, is made up of following raw material：The g of corydalis tuber 30, the g of plantain seed 25, Chinese actinidia root 25 g, seven
Ye Yizhi spends 20 g, the g of Selaginella pulvinata 25, the g of wilsonii 20, the g of radix glycyrrhizae 10, the g of the red sage root 15, the g of folium isatidis 15, the g of the fruit of Chinese wolfberry 15.
(1) by proportioning by corydalis tuber, plantain seed, Chinese actinidia root, Paris polyphylla, Selaginella pulvinata, wilsonii, radix glycyrrhizae, the red sage root,
Folium isatidis, the fruit of Chinese wolfberry are ground into fritter after being rinsed with clear water, add 75% ethanol and soak 12 hours, add the amount and medicine of 75% ethanol
The ratio of material total amount is 9.5mL: 1g；
(2) heating and refluxing extraction 3 times at 90 DEG C by the medicinal material after immersion, extraction 2 hours, filter out after extraction carry every time every time
Liquid is taken, and rejoins 75% ethanol and is extracted, the amount for rejoining 75% ethanol is the amount of 75% ethanol of addition in step (1)
0.8 times,；After 3rd extraction, extract solution is filtered out, water is added in the remaining dregs of a decoction, the ratio of the amount and medicinal material total amount that add water is
10mL: 1g, continue heat extraction 3 times at 90 DEG C, every time extraction 2 hours；Merge alcohol extract and aqueous extract respectively；
(3) Aqueous extracts in step (2) and alcohol extract are filtered under diminished pressure respectively, filter out large granular impurity, be concentrated into medicinal extract, true
Dried in vacuum freecing-dry machine after removing moisture, two kinds of extracts are mixed into obtain Chinese medicinal compound extract；
(4) Macrogol 4000, Macrogol 6000 or poloxamer matrix are added under conditions of stirring in container is heated
Heat is then 1 according to the weight of Chinese medicinal compound extract and matrix ratio until melting:12 toward melting matrix in add extract,
Pill dripping machine fluid reservoir is heated to 75-85 DEG C of temperature afterwards, Chinese medicinal compound extract and auxiliary material etc. are entered into fluid reservoir, passed through
Water dropper drips to compound traditional Chinese medicinal dripping pills material in the condensate liquid that temperature is 4 ~ 6 DEG C, and the dripping pill for collecting shaping is exported in pill dripping machine, is wiped
Surface coolant is gone, is dried, described compound traditional Chinese medicinal dripping pills is obtained, is fitted into bag and seals, 0.5g/ bags.
Instructions of taking：It is buccal, 3 times a day, each taking one bag（0.5 gram）.
Animal toxicity test：
1. take experiment mice 120, male and female half and half, 140 ~ 180g of body weight is respectively divided into 1 ~ 3 three groups, every group each 40, and often
Group Bearing Mice Life sign is good, and the physiological performance such as body weight is without exception, has comparativity.
2. the Chinese medicinal compound extract of the treatment liver cancer prepared respectively using the embodiment of the present invention 1 ~ 3 to three groups of mouse is molten
Thing is solved, gastric infusion three times a day, is continuously taken one month, observed during experiment and record the sign situation of all mouse.
3. the sign presentation of all mouse is without exception in experimentation, do not occur death condition after off-test, to every group
Five are randomly selected in mouse and carries out dissection inspection, major organs are no abnormal, from experimental result, in of the invention
Medicine compound, can safety clothes use without overt toxicity.
Clinical statisticses data：
1. case is chosen：Clinically choose the liver cancer patient 183 made a definite diagnosis, wherein male 90, women 93, age
13-68 year, average age 46 years old.
2. experimental method：The Chinese medicinal compound extract prepared respectively using the embodiment of the present invention 1 ~ 3 to 1 ~ 3 experimental group, often
Day three times, continuously takes 3 months, observes and record the recovery situation of patient.
3. curative effect judging standard：
Complete incidence graph：Tumor disappearance simultaneously continues more than one month；
Alleviate part：The maximum diameter product that is mutually perpendicular to of two, tumour reduces more than 50% and continues one month；
It is stable：The maximum diameter product that is mutually perpendicular to of two, tumour is reduced less than 50%, and increase is no more than more than 25% and continues one
Individual month；
Deteriorate：The maximum diameter product that is mutually perpendicular to of two, tumour increases above more than 25% and continues one month.
4. experimental data counts：
Main adverse reaction is digestive tract reaction, and Nausea and vomiting symptom occur in three groups of experimental groups, and three groups are showed no and blood occur
Learn adverse reaction.
5. experimental result：As can be seen from the above experimental data, the treatment liver cancer Chinese medicinal compound extract that prepared by the present invention
Total effective rate for liver cancer treatment is 91.3%, can improve immunity of organisms, significantly inhibits function of tumor, therefore illustrate this
The Chinese medicine compound prescription of invention is to treat the safe and effective medicine of liver cancer, has good clinical expansion meaning.
Claims (7)
1. a kind of Chinese medicine compound prescription for treating liver cancer, it is characterised in that it is made up of following raw material：20 ~ 30 parts of corydalis tuber,
15 ~ 25 parts of plantain seed, 15 ~ 25 parts of Chinese actinidia root, 10 ~ 20 parts of Paris polyphylla, 15 ~ 25 parts of Selaginella pulvinata, 10 ~ 20 parts of wilsonii,
5 ~ 10 parts of radix glycyrrhizae, 10 ~ 15 parts of the red sage root, 10 ~ 15 parts of folium isatidis, 10 ~ 15 parts of the fruit of Chinese wolfberry.
2. the preparation method of the Chinese medicine compound prescription for the treatment of liver cancer as claimed in claim 1, it is characterised in that comprise the following steps：
(1) by proportioning by corydalis tuber, plantain seed, Chinese actinidia root, Paris polyphylla, Selaginella pulvinata, wilsonii, radix glycyrrhizae, the red sage root, big
Leafiness, the fruit of Chinese wolfberry are ground into fritter after being rinsed with clear water, add 75% ethanol and soak 8 ~ 12 hours；
(2) heating and refluxing extraction 3 times at 90 DEG C by the medicinal material after immersion, extraction 2 hours, filter out after extraction carry every time every time
Liquid is taken, and rejoins 75% ethanol and is extracted；After 3rd extraction, extract solution is filtered out, water is added in the remaining dregs of a decoction, 90
Continue heat extraction 3 times at DEG C, every time extraction 2 hours；Merge alcohol extract and aqueous extract respectively；
(3) medicinal extract is concentrated into after filtering the aqueous extract in step (2) and alcohol extract respectively, in vacuum freeze drier
After drying, two kinds of extracts are mixed and produced.
3. the preparation method of the Chinese medicine compound prescription for the treatment of liver cancer as claimed in claim 2, it is characterised in that added in step (1)
The amount of 75% ethanol and the ratio of medicinal material total amount are 9.5mL: 1g.
4. the preparation method of the Chinese medicine compound prescription for the treatment of liver cancer as claimed in claim 2, it is characterised in that in step (2) again
The amount of 75% ethanol is added to add 0.8 times of the amount of 75% ethanol in step (1), the ratio of the amount and medicinal material total amount that add water is 10mL
∶1g。
5. the preparation method of the Chinese medicine compound prescription for the treatment of liver cancer as claimed in claim 2, it is characterised in that filtered in step (3)
To be filtered under diminished pressure.
A kind of 6. pharmaceutical preparation of the Chinese medicine compound prescription containing described in claim 1, it is characterised in that the Chinese medicine compound prescription and pharmaceutically
The formulation in any pharmacy is made in acceptable auxiliary material.
7. application of the Chinese medicine compound prescription described in claim 1 in liver-cancer medicine is treated.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105597004A (en) * | 2016-01-26 | 2016-05-25 | 青岛华之草医药科技有限公司 | Traditional Chinese medicine combination for treating cancer |
| CN105617294A (en) * | 2016-04-08 | 2016-06-01 | 烟台市华文欣欣医药科技有限公司 | Traditional Chinese medicine composition for treating liver cancer |
| CN105664046A (en) * | 2016-03-04 | 2016-06-15 | 李淑华 | Traditional Chinese medicinal preparation for treating liver cancer |
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2017
- 2017-10-24 CN CN201710998735.1A patent/CN107737224A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105597004A (en) * | 2016-01-26 | 2016-05-25 | 青岛华之草医药科技有限公司 | Traditional Chinese medicine combination for treating cancer |
| CN105664046A (en) * | 2016-03-04 | 2016-06-15 | 李淑华 | Traditional Chinese medicinal preparation for treating liver cancer |
| CN105617294A (en) * | 2016-04-08 | 2016-06-01 | 烟台市华文欣欣医药科技有限公司 | Traditional Chinese medicine composition for treating liver cancer |
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