CN108743693A - A kind of piglet health care growth promotion Chinese medicine composition, preparation method and applications - Google Patents
A kind of piglet health care growth promotion Chinese medicine composition, preparation method and applications Download PDFInfo
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Abstract
The invention discloses a kind of piglet health care growth promotion Chinese medicine compositions and preparation method thereof.The composition is by U.S. 3~9 parts by weight of Chinese grass, 5~15 parts by weight of Tibetan radix astragali, 6~18 parts by weight of Herba Rabdosiae angustifoliae, 7~21 parts by weight of bush cinquefoil flower, the bulk pharmaceutical chemicals composition of clear 4~12 parts by weight of fruit of color.The preparation method of the composition is by U.S. Chinese grass, Tibetan radix astragali, Herba Rabdosiae angustifoliae, bush cinquefoil flower, and the clear fruit mixing of color adds 7~8 times of water to impregnate 8~12h, boils and maintain 1h, filters.Filter residue adds 5~6 times of water again, boils and maintain 30min, and filtrate merges twice, concentrates, and is spray-dried, and crushes.The Chinese medicine composition adds in pig starter feed, can prevent the mixed infection of the viruses, bacterium such as circovirus, Haemophilus parasuis after weaned piglet, promotes growth, is also improved the effect of immune function, Small side effects, and noresidue is safe and convenient to use.
Description
Technical field
The invention belongs to herbal medicine pharmaceutical fields, are related to a kind of piglet health care growth promotion Chinese medicine composition, the Chinese traditional medicine composition
The preparation method and application of object.
Technical background
In the present age, as the intensive degree that the food animals such as porcine cultivate is higher and higher, in addition people are to culture efficiency
Diligent pursuit, excessive cultivation scale, excessively high cultivation density and lacking moves, and pig is made often to be in stress situation, long
Phase is in sub-health state, so, the control and prevention of disease more problems in pig production.The child care phase that pig is weaned later, and be foster
The important link of pig production and the high-incidence season of circovirus and haemophilus parasuis.After piglet leaves sow, in feeding environment
It is again gregarious with nutrition suddenly change, it establishes under the action of the undesirable elements such as new order of grade, is easy to happen slow to grow
Slowly, asthma and diarrhea be main feature early weaning piglet stress syndrome, bring heavy losses to pig production.At present
In pig production, antibiotic, hormone, chemical synthetic drug etc. are added in feed to carry out health care, health care is not only not achieved
Effect, also many side effects.Also the pig farm having carries out health care with Chinese medicine, and due to the defect of formula, often things turn out contrary to one's wishes,
It is difficult the prevention and treatment for solving pig infectious disease mixed infection.
Conventional medicament of the Chinese medicine as China, there is thousands of years of long history.Modern medicine study the result shows that, it is many
Chinese medicine contains the substances such as relatively rich carbohydrate, alkaloids, organic acid, glucoside, volatile oil, made of these substances in
Medicine preparation is used for animal, can have immune cell activated, enhances immune function, and antiviral, antibacterium, improves production at resisting stress
The superior effect such as performance, and toxic side effect is small, is not likely to produce drug resistance.There is an urgent need for explore a boar growth promotion to prevent pig again
The viruses such as smoothing filter operator, Haemophilus parasuis, bacteria mixed infection pig health care growth promotion Chinese medicine composition.
Invention content:
The purpose of the present invention is to provide a kind of piglet health care growth promotion Chinese medicine compositions.
Another object of the present invention is to provide the preparation method of above-mentioned piglet health care growth promotion Chinese medicine composition.
Further object of the present invention is to provide a kind of application of piglet health care growth promotion Chinese medicine composition.
The purpose of the present invention is what is implemented by following technical measures：
A kind of somatotrophic Chinese medicine composition of piglet health care, the composition are made of the bulk pharmaceutical chemicals of following parts by weight：U.S. Chinese grass 3~
9 parts by weight, 5~15 parts by weight of Tibetan radix astragali, 6~18 parts by weight of Herba Rabdosiae angustifoliae, 7~21 parts by weight of bush cinquefoil flower, the clear fruit of color 4~
12 parts by weight.
Above-mentioned composition is preferably made of the bulk pharmaceutical chemicals of following parts by weight：U.S. 4~5 parts by weight of Chinese grass, 6~8 weight of Tibetan radix astragali
Measure part, 8~10 parts by weight of Herba Rabdosiae angustifoliae, 9~11 parts by weight of bush cinquefoil flower, clear 6~8 parts by weight of fruit of color.
A kind of preparation method of piglet health care growth promotion Chinese medicine composition, using above-mentioned composition, steps are as follows：
1）By U.S. Chinese grass, Tibetan radix astragali, Herba Rabdosiae angustifoliae, bush cinquefoil flower, the clear fruit mixing of color；
2）Add 7~8 times of water to impregnate 8~12h, boils and maintain 1h；
3）Filtering, filter residue add 5~6 times of water, boil and maintain 30min again, and filtrate merges twice, concentration；
4）Spray drying is to get powder.
Further, the spray drying, the specific steps are：First begin to rehearse wind turbine, then opens air inlet fan, then opens steam valve
Door when waiting that temperature is to 110 DEG C in towers, opens high pressure homogenizer and dusts.
A kind of piglet health care growth promotion Chinese medicine composition is in viruses such as prevention smoothing filter operator, Haemophilus parasuis, thin
It is applied in the infectious disease of bacterium mixed infection.
The present invention draws traditional Chinese veterinary medicine marrow；U.S. Chinese grass, is labiate Meehania fargesii (Levl) C. Y. Wu) Mechania fargesii
(Levl) herb of C.Y.Wn, function deliver heat-clearing, eliminating damp, detoxifying.Cure mainly cold, fever, diarrhea dysentery abdominal pain, hepatitis, cholecystitis,
Snake bite；Tibetan radix astragali is the root of legume Tibet Radix Astragali Astragalus tibetanus Benth.ex Bunge., function
There is an invigorating qi for strengthening superficies, promoting pus discharge and tissue regeneration cures mainly eipathia asthenia, exterior deficiency spontaneous perspiration, anaemia, indigestion, oedema, and un-festering of ulcer or burst is not received
Mouthful, force effect is resisted in also antibacterial, antiviral, raising；Herba Rabdosiae angustifoliae is labiate Herba Rabdosiae angustifoliae Rabdosia
The root of angustifolia (Dunn) Hara, function has invigorating and regulating stomach, promoting blood circulation and removing obstruction in channels.Cure mainly indigestion, Keshan disease contraction pain
Bitterly, tumour；Bush cinquefoil flower is the flower of rosaceous plant bush cinqefoil Potentilla fruticosa L., and function has dampness elimination invigorating the spleen,
Dampness taste are cured mainly, are lost the appetite, body and face edema, leukorrhea with reddish discharge, mastitis；The clear fruit of color is rosaceous plant thorn stalk rose Rosa
The ripening fruits of setipoda Hemsl.et wils., function have stomach invigorating disperse accumulation, cure mainly solid cubic content stagnation, indigestion and loss of appetite deficiency of food, diarrhea；
5 kinds of compatibility of drugs can prevent swine disease poison, bacteria mixed infection, also growth promoting function.
Beneficial effects of the present invention：
The present invention is added by above-mentioned piglet health care growth promotion Chinese medicine composition in feed, and pig can be prevented again by reaching growth promotion
The purpose of the infectious diseases mixed infection such as smoothing filter operator, Haemophilus parasuis.
The present invention solves that Chinese medicine crushed material palatability is poor, additive amount is big, curative effect is single, does not adapt to baby pig disease poison, thin
The requirement of bacterium mixed infection.
Specific implementation mode
The specific implementation mode of the present invention is described in detail below, it is to be understood that protection scope of the present invention is not
It is restricted by specific implementation.
Embodiment 1：
Prescription：U.S. Chinese grass 4g, Tibetan radix astragali 6g, Herba Rabdosiae angustifoliae 8g, bush cinquefoil flower 9g, the clear fruit 6g of color.
Specific preparation process：By U.S. Chinese grass, Tibetan radix astragali, Herba Rabdosiae angustifoliae, bush cinquefoil flower, the clear fruit mixing of color, totalling medicinal material
It weighs 7 times of water and impregnates 10h, boil and maintain 1h, filter.Filter residue adds up medicinal material and weighs 5 times of water again, boils and maintains 30min, filter twice
Liquid merges, and the medicinal extract that density is 1.15, spray drying are obtained after 90 DEG C of conditions concentrate（First begin to rehearse wind turbine, then opens air inlet fan,
Then steam valve is opened, when waiting that temperature is to 110 DEG C in towers, high pressure homogenizer is opened and dusts）To get powder.
Embodiment 2：
Prescription：U.S. Chinese grass 3g, Tibetan radix astragali 5g, Herba Rabdosiae angustifoliae 6g, bush cinquefoil flower 7g, the clear fruit 4g of color.
Specific preparation process：By U.S. Chinese grass, Tibetan radix astragali, Herba Rabdosiae angustifoliae, bush cinquefoil flower, the clear fruit mixing of color, totalling medicinal material
It weighs 8 times of water and impregnates 12h, 1h is maintained after boiling, filter, filter residue adds up medicinal material and weigh 6 times of water, 30min is maintained after boiling, is filtered twice again
Liquid merges, and the medicinal extract that density is 1.15, spray drying are obtained after 90 DEG C of conditions concentrate（First begin to rehearse wind turbine, then opens air inlet fan,
Then steam valve is opened, when waiting that temperature is to 110 DEG C in towers, high pressure homogenizer is opened and dusts）To get powder.
Embodiment 3：
Prescription：U.S. Chinese grass 6g, Tibetan radix astragali 10g, Herba Rabdosiae angustifoliae 12g, bush cinquefoil flower 14g, the clear fruit 8g of color.
Specific preparation process：By U.S. Chinese grass, Tibetan radix astragali, Herba Rabdosiae angustifoliae, bush cinquefoil flower, the clear fruit mixing of color, totalling medicinal material
It weighs 7 times of water and impregnates 10h, 1h is maintained after boiling, filter, filter residue adds up medicinal material and weigh 5 times of water, 30min is maintained after boiling, is filtered twice again
Liquid merges, and the medicinal extract that density is 1.15, spray drying are obtained after 90 DEG C of conditions concentrate（First begin to rehearse wind turbine, then opens air inlet fan,
Then steam valve is opened, when waiting that temperature is to 110 DEG C in towers, high pressure homogenizer is opened and dusts）To get powder.
Embodiment 4：
Prescription：U.S. Chinese grass 9g, Tibetan radix astragali 15g, Herba Rabdosiae angustifoliae 18g, bush cinquefoil flower 21g, the clear fruit 12g of color.
Specific preparation process：By U.S. Chinese grass, Tibetan radix astragali, Herba Rabdosiae angustifoliae, bush cinquefoil flower, the clear fruit mixing of color, totalling medicinal material
It weighs 8 times of water and impregnates 8h, 1.5h is maintained after boiling, filter, filter residue adds up medicinal material and weighs 6 times of water again, 1h is maintained after boiling, twice filtrate
Merge, the medicinal extract that density is 1.15, spray drying are obtained after 90 DEG C of conditions concentrate（First begin to rehearse wind turbine, then opens air inlet fan, so
After open steam valve, when waiting that temperature is to 110 DEG C in towers, open high pressure homogenizer and dust）To get powder.
The effect of effect experiment is further illustrated the present invention below.
One, the present invention is to pig growth promotion feeding experiment
1, experimental animal：The similar 28 age in days Soviet Union ginger pig wean pig 64 of parity, age in days is selected, male and female is fifty-fifty, is randomly divided into 4
Group, every group 16.
2, method：4 group basal diets are identical, the 1st group（High dose group）Chinese medicine group of the present invention is added in feed per ton
Close 700 grams of object（It is prepared by embodiment 1）, the 2nd group（Middle dose group）500 grams of Chinese medicine composition of the present invention is added in feed per ton
（It is prepared by embodiment 1）, the 3rd group（Low dose group）300 grams of Chinese medicine composition of the present invention is added in feed per ton（By embodiment
1 prepares）, the 4th group（Control group）Basal diet feed is only fed, any drug is not added with.Free water and feeding, 30 days experimental periods；
Experimental basis feed formula is shown in Table 1.
1 basal diet feed formula of table and trophic level（%）
3, feeding management：
（1）Disinfection：Before being enclosed in test pig, colony house is sterilized with 10% Betagen Solution, and test pig body surface is disappeared with 0.1% bromogeramine
Poison；
（2）Formal test：On April 21st, 2018, morning 7:00 claims initial weight, morning 7 on May 20th, 2018 on an empty stomach:00 claims on an empty stomach
End weight, totally 30 days, accurate recording feed intake, the situations such as spirit, fur, excrement, breathing of pig；
（3）Under identical feeding and management condition, special messenger is responsible for recording data test pig.
4, content is tested：
Weightening, feed consumption, feedstuff-meat ratio, health status, specific data are shown in Table 2.It takes a blood sample before off-test, detaches serum, measure serum
Middle total protein, albumin, globulin content are analyzed using the XD811 semiautomatic biochemistries of upper Hisoon up to medical instrument companies' production
Instrument, using scattering rate turbidimetry for Determination, assay kit is purchased from health Bioisystech Co., Ltd of Erie, and Serum Indexes measure knot
Fruit is shown in Table 3.
Diarrhea criterion：Every morning 8:00 timing observation piglet excrement situation, excrement be divided into normal, loose stool, it is sticky,
5 grades of water sample and bloody stool, rear 4 grades are judged to diarrhea.
Test data sheet：Every group of diarrhea of pigs head is recorded, diarrhea rate is calculated（Diarrhea rate=diarrhea piglet head/total head of piglet
Number）
Influence of 2 compound traditional Chinese medicine composite of table to Production Performance of Weaning Pigs
Note：Compared with the control group, * ﹤ 0.05
As can be seen from Table 2, middle dose group effect is best, 19.95% is improved than control group daily gain, significant difference（P ﹤ 0.05）, diarrhea
Rate declines 61.26 %（P ﹤ 0.05）.High dose group, low dose group are respectively increased 9.68%, 0.35% than control group daily gain, difference
Not significantly（P ﹥ 0.05）, diarrhea rate 63.97 % significant differences of decline（P ﹤ 0.05）, 23.52%, difference is not notable（P ﹥ 0.05）.
Influence of 3 compound traditional Chinese medicine composite of table to piglet haemocyanin index
Note：Compared with the control group, * ﹤ 0.05
From table 3 it can be seen that compared with the control group, high dose group total protein, albumin, globulin be respectively increased 14.89%,
11.40%, 19.25%, difference is not notable（P ﹥ 0.05）.Middle dose group is respectively increased 26.81%, 29.81%, 23.95%, difference pole
Significantly（P ﹤ 0.01）.Low dose group is respectively increased 7.83%, 4.15%, 12.37%, and difference is not notable（P ﹥ 0.05）.Haemocyanin carries
Height, display body's resistance to disease enhancing.
Two, prevention result of the present invention to virus and bacteria mixed infection
Jiangsu Xiuqian City Sihong County pig farm, on November 1st, 2017 are divided into 2 groups, the 1st group of 300 sons with weanling pig 385
Pig, with Chinese medicine composition of the present invention（It is prepared by embodiment 2）500 grams of progress health cares are added in feed per ton, swinery is compared always
Relatively stablize, no any abnormal appearance.2nd group of 85 piglet Amoxicillin health cares, feed per ton add 750 grams, are opened within 5th from November
Begin, the 2nd group there are individual temperature of pig body to rise to 40.6 DEG C or so, spiritual depressed, anorexia occurs.November 9, full mass-sending disease,
Performance breathes fast, rubefaction, diarrhea, inguinal lymphadenopathy.Dissect 4；Dissect changes：The visible pericardium product of sick pig dissect
Water；Lymph nodes of body as a whole enlargement, especially inguinal lymph nodes and submandibular lymph nodes, section are turned up, and have weak yellow liquid outflow；Lung
Atrophy；Hydroabdomen, each internal organs adhesion, there is albumen exudation；The slight enlargement of spleen, kidney is pale, and quality becomes fragile, and has needle point individually
Shape blutpunkte；There is part pig liver enlargement, yellow is presented；There is part pig stomach mucous membrane ulcer occur；Arthroedema has faint yellow
Liquid oozes out.
Laboratory diagnosis
1, viral diagnosis：Acquisition sick dead pig pathological material of disease is sent to Yangzhou University and carries out Pathogen test, has detected porcine circovirus 2 type respectively
（PCR method）, porcine reproductive and respiratory syndrome virus（RT-PCR method）, porcine pseudorabies virus（PCR method）, swine fever virus
（RT-PCR method）, as a result only detection has circovirus, other viruses not to detected.
2, bacteriodiagnosis：
（1）Bacteria Culture；It is sterile that sick pig lungs, joint fluid, chambers of the heart hydrops and cardiac blood is taken to be inoculated in TSA（Containing 5% calf blood
Clearly, 0.005%NAD）Solid medium is inverted in culture 36h~48h in 37 DEG C of incubators.The form of bacterium colony on solid medium
For circle, grey, translucent, smooth moistening, tip-like size；Bacterium is visible single short under microscope through Gram's staining
Rod-shaped or short chain shape gramnegative bacterium.
（2）Bacteria bio is tested；The bacterium isolated and purified is handed over first on sheep blood agar plate with staphylococcus
Fork scribing line, the hemolytic of its NAD dependence of culture identification, reselection is dependent on NAD but the bacterium without hemolytic carries out it
Its biochemical identification.Every biochemical identification result meets the feature of haemophilus parasuis reference culture, as a result shows the separation
Bacterium is haemophilus parasuis.
3, treatment：After the onset of 2nd group of 85 pigs, with Florfenicol and Effect of APS in Treating, until November 20, dead 38
Head, the death rate 44.70% cause very big economic loss.
Three, a kind of piglet health care growth promotion Chinese medicine composition prevention smoothing filter operator, the viruses such as Haemophilus parasuis,
It is applied in the infectious disease of bacteria mixed infection, concrete case is as follows：Zhejiang Jiaxing city pig farm, not feeding mother pig, 2 months 2016
10, weanling pig 1120 is purchased from market, castrating is carried out after 7 days for raising and vaccine inoculation was fallen ill successively at 20 days 2 months, body
Temperature is at 40.6 DEG C or so, and appearance spirit is depressed, and anorexia breathes fast, rubefaction, diarrhea, inguinal lymphadenopathy.It cuts open
Inspection 4；Dissect changes：The visible hydropericardium of sick pig dissect；It is drenched under lymph nodes of body as a whole enlargement, especially inguinal lymph nodes and jaw
It fawns on, section is turned up, and has weak yellow liquid outflow；Lungs are in diffusivity interstitial pneumonia, have part to become in pancreas sample meat；It accumulates in abdominal cavity
Water, each internal organs adhesion, there is albumen exudation；The slight enlargement of spleen, kidney is pale, and quality becomes fragile, and has tip-like blutpunkte individually；Have
Yellow is presented in part pig liver enlargement；There is part pig stomach mucous membrane ulcer occur；Arthroedema has weak yellow liquid exudation.Through
Laboratory diagnosis is circovirus and haemophilus parasuis mixed infection, uses the present composition（It is prepared by embodiment 4）Spice,
Feed per ton adds 1000g, is used in conjunction 6 days, dead 78, remaining rehabilitation.With drug of the present invention in Jiangsu, Zhejiang, Shandong, Anhui etc.
Treatment piglet circovirus and 16000 many cases of haemophilus parasuis mixed infection are saved, cure rate is 90% or more.It is shown in Table 4.
4 clinical treatment outcome of table
Four, safety testing
For the toxic side effect of clear invention formulation, and accurate, objective appraisal is made to its safety, is carried for clinical application
For scientific basis, it is ensured that drug safety has carried out the toxicity test of the present invention.
Acute toxicity test：By carrying out the present invention's to ICR mouse（It is prepared by embodiment 2）LD50It is resistance to maximum
Measured experiments have shown that, by design dosage by oral administration after, each group mouse behavior sign is normal in 8 days, do not occur poisoning symptom and
It is dead.Therefore LD can not be determined50, and have to be using maximum dosage-feeding 60g/kg as maximum dose level.After 10th day slaughters, each group mouse
The internal organs such as liver,kidney,spleen, lung without lesion.
Long term toxicity test：SD rats 30 are selected, are divided into 3 groups, every group 10, half male and half female gives various dose
（30.0,15.0,7.5g crude drugs/kg）The present invention Chinese medicine preparation（It is prepared by embodiment 3）, daily perfusion is primary, even
It is 30 days continuous.Three dosage group animal animations of the present invention are good, appearance sign, behavioral activity, food-intake and body weight increase
Variation without exception.The internal organs such as liver,kidney,spleen, the lung of each group rat are without lesion.Show the present invention have no toxic side effect with it is bad anti-
It answers, clinical application is safe and reliable.
The description of the aforementioned specific exemplary embodiment to the present invention is in order to illustrate and illustration purpose.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to the above instruction, can much be changed
And variation.The purpose of selecting and describing the exemplary embodiment is that explaining the specific principle of the present invention and its actually answering
With so that those skilled in the art can realize and utilize the present invention a variety of different exemplary implementation schemes and
Various chooses and changes.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (6)
1. a kind of piglet health care growth promotion Chinese medicine composition, which is characterized in that the composition by following parts by weight bulk pharmaceutical chemicals group
At：U.S. 3~9 parts by weight of Chinese grass, 5~15 parts by weight of Tibetan radix astragali, 6~18 parts by weight of Herba Rabdosiae angustifoliae, 7~21 weight of bush cinquefoil flower
Part, clear 4~12 parts by weight of fruit of color.
2. piglet health care growth promotion Chinese medicine composition according to claim 1, which is characterized in that the composition is by following heavy
Measure the bulk pharmaceutical chemicals composition of part：U.S. 4~5 parts by weight of Chinese grass, 6~8 parts by weight of Tibetan radix astragali, 8~10 parts by weight of Herba Rabdosiae angustifoliae, gold are old
9~11 parts by weight of plum blossom, clear 6~8 parts by weight of fruit of color.
3. piglet health care growth promotion Chinese medicine composition according to claim 1, which is characterized in that prepared by the composition
Dosage form is powder.
4. a kind of preparation method of piglet health care growth promotion Chinese medicine composition, which is characterized in that steps are as follows：
1）By U.S. Chinese grass, Tibetan radix astragali, Herba Rabdosiae angustifoliae, bush cinquefoil flower, the clear fruit mixing of color；
2）Add 7~8 times of water to impregnate 8~12h, boils and maintain 1h；
3）Filtering, filter residue add 5~6 times of water, boil and maintain 30min again, and filtrate merges twice, concentration；
4）Spray drying is to get powder.
5. a kind of preparation method of piglet health care growth promotion Chinese medicine composition according to claim 4, which is characterized in that described
Spray drying, the specific steps are：First begin to rehearse wind turbine, then opens air inlet fan, then opens steam valve, waits in towers temperature to 110 DEG C
When, it opens high pressure homogenizer and dusts.
6. a kind of piglet health care growth promotion Chinese medicine composition is in viruses, bacteriums such as prevention smoothing filter operator, Haemophilus parasuis
It is applied in the infectious disease of mixed infection.
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| CN109394859A (en) * | 2018-10-15 | 2019-03-01 | 江苏农牧科技职业学院 | The pharmaceutical composition and its preparation method and application for preventing and treating Haemophilus parasuis |
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