CN104845797A - Health-care dark plum-mulberry wine and preparation method thereof - Google Patents

Abstract

The invention specifically relates to a health-care dark plum-mulberry wine and a preparation method thereof, belonging to the field of medicinal wine. The wine comprises the following components by weight: 100 to 150 parts of dark plum pulp, 60 to 100 parts of mulberry, 50 to 80 parts of seabuckthorn, 30 to 50 parts of spine date seed, 10 to 30 parts of dried ginger, 12 to 20 parts of costustoot, 10 to 15 parts of ginseng, 10 to 15 parts of Chinese angelica, 30 to 50 parts of cassia seed and 300 to 500 parts of base liquor. The preparation method comprises the following steps: a, separately purifying the dark plum pulp and the spine date seed so as to obtain extracts; b, separately squeezing juice from the mulberry and the seabuckthorn so as to obtain mulberry juice and seabuckthorn juice; c, ultrasonically extracting the dried ginger, the costustoot, the ginseng and the cassia seed with an ethanol extraction liquid with ethanol content of 70% to 80% so as to obtain respective extracts thereof; and d, adding the obtained extracts and squeezed juices into the base liquor, then carrying out uniform mixing, sealing the obtained mixture for fermentation at 30 to 40 DEG C for 2 to 3 days and then carrying out fermentation at room temperature for 3 to 5 days so as to obtain the health-care dark plum-mulberry wine.

Description

A kind of dark plum mulberry health-care wine and preparation method thereof

Technical field

The invention belongs to medicinal liquor field, in particular to a kind of dark plum mulberry health-care wine and preparation method thereof.

Background technology

Dark plum is the goods of integration of drinking and medicinal herbs, the Chinese medicinal materials being green plum after processing, have astringe the lung, puckery intestines, promote the production of body fluid, effect of claming ascaris.Organic acid contained by dark plum can also kill the pathogenic bacterias such as the mould in gi tract.And the effect such as long-term edible dark plum also has anti-aging, purifies the blood, Ginseng Extract, constipation, be particularly useful for the city working crowd that current pressure is large.

Chinese patent application 201110239745.X, discloses a kind of dark plum wine and brewing method, the stomach-fortifying liquor made with dark plum, sealwort, dried orange peel, yellow rice wine, and the raw material making effective ingredient consists of dark plum, sealwort, dried orange peel, yellow rice wine, and its ratio is 1:1:1:20.Preparation method is: say dark plum, sealwort, dried orange peel pulverization mixing respectively, load and fill in the container of yellow rice wine, sealing, low baking temperature trains five hours.

Chinese patent application 201410363691.1, discloses a kind of dark plum health promoting wine, and main raw material used and weight ratio thereof are: dark plum preserved fruit 500g, wolfberry fruit 30g, rice vinegar 600g, honey 500g, white wine base wine 10000g.Its production technique is: get dark plum preserved fruit 500g, wolfberry fruit 30g, rice vinegar 600g, honey 500g insert after in altar, add white wine base wine 10000g to soak, stir 3 every day, after foaming foot 6 days, leached by raw materials all in wine, wine jar is built, and shines foot 15 days under being placed on the sun, again after carefully filtering, be finished product.

Chinese patent application 98118278.X, disclose a kind of dark plum wine and production technique thereof, former wine alcoholic strength is 18-24% (V/V), batching is dark plum, be not less than the granulated sugar of 120g/L proportioning, be not less than the glucose of 12g/L proportioning, a small amount of citric acid and foodstuff additive, soak more than 30 hours.

In three above-mentioned patents, be all use traditional brewing method to make dark plum wine, the utilization ratio of aforesaid method to raw material is relatively low, and the activeconstituents eduction rate of raw material is lower, is difficult to the utilization that is absorbed by the body fully.And in latter two patents scheme, adding a large amount of granulated sugar, this patient higher to part blood sugar should not drink, and cannot enjoy the health-care effect that dark plum brings health.

Summary of the invention

The object of the present invention is to provide a kind of dark plum mulberry health-care wine, be suitable for all groups and drink, have strengthening spleen and nourishing stomach effect well, be particularly useful for cold of insufficiency type physique crowd, long-term drinking has adjuvant treatment effect well for chronic bronchitis patient.

Another object of the present invention is to provide a kind of method preparing dark plum mulberry health care wine.

The object of the present invention is achieved like this: a kind of dark plum mulberry health-care wine, with weight parts, prepare described dark plum mulberry health-care wine and comprise following raw material: Fructus Mume 100-150 part, mulberry fruit 60-100 part, sea-buckthorn 50-80 part, Spina Date Seed 30-50 part, rhizoma zingiberis 10-30 part, banksia rose 12-20 part, ginseng 10-15 part, Radix Angelicae Sinensis 10-15 part, Semen Cassiae 30-50 part, base wine 300-500 part.

The raw material used in we is fresh, pure natural, the green material of nothing interpolation and deep processing.Wherein, dark plum is put down, return liver, spleen, lung, large intestine channel, and effect that having astringes the lung promotes the production of body fluid, has curative effect well for chronic cough of deficiency lung.Mulberries are cold in nature, the thoughts of returning home, liver, kidney, have nourishing YIN and supplementing blood well, effect of moisturizing of promoting the production of body fluid.Sea-buckthorn is warm in nature, returns spleen, stomach, lung, the heart channel of Hang-Shaoyin, and for cough-relieving apophlegmatic, promoting blood circulation to remove blood stasis has curative effect well.Spina Date Seed is put down, and return liver, courage, the heart channel of Hang-Shaoyin, can nourish heart tonifying liver, tranquillizing by calming the heart.Rhizoma zingiberis can warming spleen and stomach for dispelling cold; The banksia rose can promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; Ginseng can be answered arteries and veins and admittedly be taken off, and promotes the production of body fluid and nourishes blood, intelligence development of calming the nerves; Radix Angelicae Sinensis is warm in nature, can enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, relax bowel; Semen Cassiae removing heat to brighten vision, to relax bowel.

In we, based on dark plum, mulberries, sea-buckthorn and Spina Date Seed, nourishing YIN and benefiting blood, loose stasis of blood cough-relieving, simultaneously in conjunction with rhizoma zingiberis, the banksia rose, ginseng, Radix Angelicae Sinensis, the loose cold promoting the circulation of qi of Semen Cassiae, clear away heart-fire ease constipation, strengthening spleen and nourishing blood, fundamentally impels body function to reach optimum regime, reaches effect of clearing away the heart fire and tranquillizing.

Meanwhile, dark plum is basic food, containing a large amount of organic acid, can be transformed into alkaline matter very soon, have antioxygenation well after intestines wall absorbs.Mulberries contain multiple amino acids, VITAMIN and the nutritive substance such as organic acid, carotene, and dark plum and mulberries combine the anti-oxidation efficacy that greatly can improve health promoting wine.

In conjunction with adding sea-buckthorn, Spina Date Seed and rhizoma zingiberis, for chronic bronchitis, there is auxiliary curative effect well, especially for hypofunction of both the spleen and the lung chronic bronchitis, there is curative effect well.Because this disease is main, because the deficiency syndrome of the lung is insufficiency of the spleen, so breathe hard, chest gastral cavity ruffian is vexed, and this void of lung qi, weakened defensive QI, is affected by the cold, and lung qi is more hindered, and phlegm is contained by wet turning, in we, dark plum returns liver, spleen, lung, and sea-buckthorn returns spleen, lung, and mulberries return liver, promote the production of body fluid and moisturize, nourishing YIN and supplementing blood, Spina Date Seed returns liver, nourishes heart and enriches blood, tranquillizing by calming the heart, rhizoma zingiberis can warming spleen and stomach for dispelling cold, fundamentally the spleen pulmonary function of enhancing body, and keep body raising for the opposing of chill, reduce the damage of lung qi, weaken the generation of symptom.

The banksia rose, ginseng, Radix Angelicae Sinensis, Semen Cassiae combine the effect adding and health promoting wine can be made to have loose cold invigorating the spleen, nourshing blood and promoting blood circulation, ease constipation, fundamentally impel the metabolism of body healthy normal, ensure the state of health of body, promote the recovery of damage body.

Further, with weight parts, prepare described dark plum mulberry health-care wine and comprise following raw material: Fructus Mume 120-140 part, mulberry fruit 70-90 part, sea-buckthorn 60-70 part, Spina Date Seed 35-45 part, rhizoma zingiberis 15-25 part, banksia rose 15-18 part, ginseng 12-14 part, Radix Angelicae Sinensis 11-14 part, Semen Cassiae 35-45 part, base wine 350-450 part.

Further, with weight parts, prepare described dark plum mulberry health-care wine and comprise following raw material: Fructus Mume 130 parts, 80 parts, mulberry fruit, sea-buckthorn 65 parts, Spina Date Seed 40 parts, rhizoma zingiberis 20 parts, the banksia rose 16 parts, ginseng 13 parts, Radix Angelicae Sinensis 13 parts, Semen Cassiae 40 parts, base wine 400 parts.

Wherein the add-on of above-mentioned each raw material can be added according to real needs, needs that strengthening promotes the production of body fluid and moisturizes, effect of ease constipation, can relatively add into some mulberries and Semen Cassiae in value range, reduce the add-on of rhizoma zingiberis.If need to strengthen relieving cough and moistening lung effect, relatively can add into dark plum and sea-buckthorn in value range.

Further, described raw material also comprises: N,O-Diacetylmuramidase 0.01-0.02 part.

In order to improve mixed solution bacteriostasis property during the fermentation, the fungistat of lyase bacterium as health promoting wine can also be added.

In order to make, the health promoting wine that obtains is all grows up drinkable per capita, and be unlikely to drunk, further, described base wine is the fermented wine of the alcohol number of degrees≤20%.The Shaoxing high-grade Shaoxing wine yellow rice wine of such as 14 °, the dry red winew of 12 °, the beer of 10 °, the osmanthus wine of 12.5 °.

Present invention also offers the method preparing described dark plum mulberry health-care wine, comprise the following steps:

A, the Fructus Mume of described number, Spina Date Seed to be purified respectively, obtain extract;

B, the mulberries of described number, sea-buckthorn to be squeezed the juice respectively, obtain morisuccus and juice of Fructus Hippophae;

C, the ethanol extract being 70-80% by the rhizoma zingiberis of described number, the banksia rose, ginseng, Radix Angelicae Sinensis, Semen Cassiae use ethanol content carry out ultrasonic extraction and obtain its extract respectively;

D, the described extract obtained and squeezing juice are all added in described base wine and mixed, at 30-40 DEG C of lower seal fermentation 2-3 days, normal temperature bottom fermentation 3-5 days is finished product afterwards.

Provided by the inventionly prepare in the method for dark plum mulberry health-care wine, according to the different qualities of raw material, activeconstituents in raw material is extracted respectively, compare with traditional infusion method, method provided by the invention, its ground of activeconstituents to raw material extraction rate improves 50-70%, improves the value utilization ratio of product.

Wherein the extract of dark plum has antibiotic effect well, all has restraining effect for intestinal bacteria, Corynebacterium diphtheriae etc., can be improved the antibiotic effect of health promoting wine by leach extraction method.Containing a large amount of oxidation-resistant active ingredients in the extract of Spina Date Seed, Flavonoid substances.The alcohol extract of rhizoma zingiberis has anti-inflammatory, antipyretic, analgesic effect, and the alcohol extract of the banksia rose has effect of anti-inflammatory cholagogic, the alcohol extract of ginseng has effect of hypoglycemic, and the alcohol extract of Radix Angelicae Sinensis has curative effect well for asthma, and the alcohol extract of Semen Cassiae has better bacteriostasis efficacy.

So, the dark plum mulberry health-care wine made by method provided by the invention, more the degree of depth extract the activeconstituents in raw material, not only increase the utilization ratio of raw material, and make it reach significant health-care effect, it is anti-oxidant good with fungistatic effect simultaneously, also has curative effect well for chronic bronchitis.

Further, in step a, the method extracting the extracting solution of described Fructus Mume and Spina Date Seed is specially:

Described Fructus Mume crushed after being dried is become 70-80 object dark plum powder, filter with after distilled water immersion 2-3h, after spin concentration, to obtain Fructus Mume extract for subsequent use in underpressure distillation;

According to the extract that the method is made, containing the raw-material extract of 1.5g in its 1mL extracting solution.

50-60 mesh sieve is crossed after being pulverized by described Spina Date Seed, 70-80 DEG C with petroleum ether degreasing process after, the ethanol extract refluxing extraction using ethanol content to be 55-60% at 76-77 DEG C once, extraction time controls as 4-5h, elimination Slag recovering extracting solution, concentrated postlyophilization obtains Semen Ziziphi Spinosae extract.

Further, in step c, the concrete grammar of ultrasonic extraction is:

The rhizoma zingiberis of described number, the banksia rose, ginseng, Radix Angelicae Sinensis, Semen Cassiae are pulverized respectively into 60-80 object powder, be that powder joins in described ethanol extract by 1:15-20 respectively according to feed liquid mass volume ratio, ultrasonic extraction is carried out twice respectively under 400-500W power, each extraction time is 20-30min, and merging filtrate Rotary Evaporators is concentrated to be placed on dry 10-12h in freeze drier and to make extract dry powder.

Further, in described steps d, after 30-40 DEG C of lower seal fermentation 2-3 days, also comprise: the lyase bacterium adding described number, mixing.

During we are raw materials used, dark plum (MUMEFRUCTUS) is the dry almost ripe fruit of rose department plant plum Prunus mume (Sieo.) Sieb.etZuce..Summer gathers when fruit is closely ripe, vexed to look blackening after oven drying at low temperature.

Mulberry fruit (MORI FRUCTUS) is the dry fruit ear of moraceae plants mulberry Morus alba L..Gather when 4 ~ June, fruit reddened. dry, or dry after slightly steaming.

Rhizoma zingiberis (ZINGIBERIS RHIZOMA): be the dry rhizome of zingiber Zingiberoj-jicinale Rosc..Winter excavates, and removing fibrous root and silt, dry or cryodrying.Take advantage of fresh slices to dry or cryodrying person is called " dried ginger slice ".

The banksia rose (AUCKLANDIAE RADIX) is the feverfew banksia rose, the dry root of 4ucklandialappa Decne..Autumn, season in winter two excavate, and removing silt and fibrous root, segment, large vertical profile again becomes lobe, hits tertia after drying.

Ginseng (GINSENG RADIX ET RHIZOMA) is the dry root welding technology of Araliaceae ginseng Panax ginseng C.A.Mey..Excavate more than autumn, clean through drying or drying.Being commonly called as " garden ginsent " of cultivation; The title " ginseng under forest " of sowing self-sow under mountain forest wild state, practises and claiming in " seed sea ".

Radix Angelicae Sinensis (RADIX ANGELICAE SINENSIS), this product is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.

Sea-buckthorn (HIPPOPHAE FRUCTUS), this strain Mongols, Tibetan's conventional crude drugs.For the dry mature fruit of Elaeangnaceae plant sea-buckthorn Hippophae thamnoides L..Autumn, season in winter two fruit maturation or adfreezing time gather, removing impurity, dry or dry after steaming.

Spina Date Seed (ZIZIPHI SPINOSAE SEMEN) is the dry mature seed of Rhamnaceae plant wild jujube Ziziphus jujuba Mill.var.spinosa (Bunge) Hu ex H.F.Chou.Time of the year when autumn changes into winter gathers mature fruit, removing pulp and nucleocapsid, collects seed, dries.

Semen Cassiae (CASSIAE SEMEN) is the dry mature seed of leguminous plants Cassia tora Cassia obtusifol iaL or little Cassia tora Cassia tora L.To gather autumn mature fruit, dry, lay seed, removing impurity.

In we, most of raw material is warm property raw material, is particularly useful for health cold of insufficiency type crowd.

This product color and luster is limpid, and taste is sour-sweet few pained, is applicable to sooner or later taking every day, each 10-15mL.

Compared with prior art, feature of the present invention is, 1. uses the raw material of integration of drinking and medicinal herbs or food materials as raw material completely, without chemical additive; 2. extraction process is meticulousr, improves the utilization ratio of raw material, improves the utilization ratio of the activeconstituents in raw material; 3. with the bulk drug of food materials in conjunction with integration of drinking and medicinal herbs, reach in health takes care of health improve the health, consolidate hold up unit effect.

Compared with prior art, the invention has the advantages that, 1. moral character is partially warm, is especially suitable for cold of insufficiency type physique crowd; 2. there is the remarkable efficacy of strengthening spleen and nourishing stomach well; 3. there is auxiliary curative effect well for chronic bronchitis shape.

Embodiment

Below by specific embodiment, the present invention is described in further detail.

Embodiment 1:

A kind of dark plum mulberry health-care wine, prescription:

With weight parts, prepare described dark plum mulberry health-care wine and comprise following raw material: Fructus Mume 100g, mulberry fruit 60g, sea-buckthorn 50g, Spina Date Seed 30g, rhizoma zingiberis 10g, banksia rose 12g, ginseng 10g, Radix Angelicae Sinensis 10g, Semen Cassiae 30g, the yellow rice wine high-grade Shaoxing wine 300g of 14 °.

Preparation method:

A, described Fructus Mume crushed after being dried is become 70 object dark plum powder, filter with after distilled water immersion 2h, after spin concentration, to obtain Fructus Mume extract for subsequent use in underpressure distillation; Cross 50 mesh sieves after being pulverized described Spina Date Seed, 70 DEG C with petroleum ether degreasing process after, use at 76 DEG C ethanol content be the ethanol extract refluxing extraction of 55% once, extraction time controls as 4h, elimination Slag recovering extracting solution, concentrated postlyophilization obtains Semen Ziziphi Spinosae extract, for subsequent use;

B, described mulberries, sea-buckthorn to be squeezed the juice respectively, obtain morisuccus and juice of Fructus Hippophae, for subsequent use;

C, described rhizoma zingiberis, the banksia rose, ginseng, Radix Angelicae Sinensis, Semen Cassiae to be pulverized respectively be 60 object powder, be that powder joins in described ethanol extract by 1:15 respectively according to feed liquid mass volume ratio, ultrasonic extraction is carried out twice respectively under 400W power, each extraction time is 20min, merging filtrate Rotary Evaporators concentrates and is placed on dry 10h in freeze drier and makes respective extract dry powder, for subsequent use;

D, the described extract obtained and squeezing juice are all added in the Shaoxing high-grade Shaoxing wine of 14 ° and mixed, ferment 2 days at 30 DEG C of lower seals, normal temperature bottom fermentation is finished product in 3 days afterwards.

Embodiment 2:

A kind of dark plum mulberry health-care wine, prescription:

With weight parts, prepare described dark plum mulberry health-care wine and comprise following raw material: Fructus Mume 150g, mulberry fruit 100g, sea-buckthorn 80g, Spina Date Seed 50g, rhizoma zingiberis 30g, banksia rose 20g, ginseng 15g, Radix Angelicae Sinensis 15g, Semen Cassiae 50g, N,O-Diacetylmuramidase 0.02g, the dry red winew 500g of 12 °.

Preparation method:

A, described Fructus Mume crushed after being dried is become 80 object dark plum powder, filter with after distilled water immersion 3h, after spin concentration, to obtain Fructus Mume extract for subsequent use in underpressure distillation; Cross 60 mesh sieves after being pulverized described Spina Date Seed, 80 DEG C with petroleum ether degreasing process after, use at 77 DEG C ethanol content be the ethanol extract refluxing extraction of 60% once, extraction time controls as 5h, elimination Slag recovering extracting solution, concentrated postlyophilization obtains Semen Ziziphi Spinosae extract, for subsequent use;

B, described mulberries, sea-buckthorn to be squeezed the juice respectively, obtain morisuccus and juice of Fructus Hippophae, for subsequent use;

C, described rhizoma zingiberis, the banksia rose, ginseng, Radix Angelicae Sinensis, Semen Cassiae to be pulverized respectively be 70 object powder, be that powder joins in described ethanol extract by 1:20 respectively according to feed liquid mass volume ratio, ultrasonic extraction is carried out twice respectively under 500W power, each extraction time is 30min, merging filtrate Rotary Evaporators concentrates and is placed on dry 12h in freeze drier and makes respective extract dry powder, for subsequent use;

D, the described extract obtained and squeezing juice are all added in the dry red winew of 12 ° and mixed, ferment 3 days at 40 DEG C of lower seals, normal temperature bottom fermentation adds described lyase bacterium for 5 days and is finished product afterwards.

Embodiment 3:

A kind of dark plum mulberry health-care wine, prescription:

With weight parts, prepare described dark plum mulberry health-care wine and comprise following raw material: Fructus Mume 130g, mulberry fruit 80g, sea-buckthorn 65g, Spina Date Seed 40g, rhizoma zingiberis 20g, banksia rose 16g, ginseng 13g, Radix Angelicae Sinensis 13g, Semen Cassiae 40g, N,O-Diacetylmuramidase 0.01g, the beer 400g of 10 °.

Preparation method:

A, described Fructus Mume crushed after being dried is become 70 object dark plum powder, filter with after distilled water immersion 3h, after spin concentration, to obtain Fructus Mume extract for subsequent use in underpressure distillation; Cross 60 mesh sieves after being pulverized described Spina Date Seed, 70 DEG C with petroleum ether degreasing process after, use at 77 DEG C ethanol content be the ethanol extract refluxing extraction of 60% once, extraction time controls as 5h, elimination Slag recovering extracting solution, concentrated postlyophilization obtains Semen Ziziphi Spinosae extract, for subsequent use;

B, described mulberries, sea-buckthorn to be squeezed the juice respectively, obtain morisuccus and juice of Fructus Hippophae, for subsequent use;

C, described rhizoma zingiberis, the banksia rose, ginseng, Radix Angelicae Sinensis, Semen Cassiae to be pulverized respectively be 70 object powder, be that powder joins in described ethanol extract by 1:18 respectively according to feed liquid mass volume ratio, ultrasonic extraction is carried out twice respectively under 450W power, each extraction time is 25min, merging filtrate Rotary Evaporators concentrates and is placed on dry 11h in freeze drier and makes respective extract dry powder, for subsequent use;

D, the described extract obtained and squeezing juice are all added in the beer of 10 ° and mixed, ferment 3 days at 40 DEG C of lower seals, normal temperature bottom fermentation adds described lyase bacterium for 3 days and is finished product afterwards.

Embodiment 4:

A kind of dark plum mulberry health-care wine, prescription:

With weight parts, prepare described dark plum mulberry health-care wine and comprise following raw material: Fructus Mume 120g, mulberry fruit 70g, sea-buckthorn 60g, Spina Date Seed 35g, rhizoma zingiberis 15g, banksia rose 15g, ginseng 12g, Radix Angelicae Sinensis 11g, Semen Cassiae 35g, the osmanthus wine 350g of 12.5 °.

Preparation method:

A, described Fructus Mume crushed after being dried is become 75 object dark plum powder, filter with after distilled water immersion 2.5h, after spin concentration, to obtain Fructus Mume extract for subsequent use in underpressure distillation; Cross 55 mesh sieves after being pulverized described Spina Date Seed, 75 DEG C with petroleum ether degreasing process after, use at 77 DEG C ethanol content be the ethanol extract refluxing extraction of 58% once, extraction time controls as 4.5h, elimination Slag recovering extracting solution, concentrated postlyophilization obtains Semen Ziziphi Spinosae extract, for subsequent use;

B, described mulberries, sea-buckthorn to be squeezed the juice respectively, obtain morisuccus and juice of Fructus Hippophae, for subsequent use;

C, described rhizoma zingiberis, the banksia rose, ginseng, Radix Angelicae Sinensis, Semen Cassiae to be pulverized respectively be 70 object powder, be that powder joins in described ethanol extract by 1:16 respectively according to feed liquid mass volume ratio, ultrasonic extraction is carried out twice respectively under 420W power, each extraction time is 28min, merging filtrate Rotary Evaporators concentrates and is placed on dry 12h in freeze drier and makes respective extract dry powder, for subsequent use;

D, the described extract obtained and squeezing juice are all added in the osmanthus wine of 12.5 ° and mixed, ferment 3 days at 40 DEG C of lower seals, normal temperature bottom fermentation is finished product in 4 days afterwards.

Embodiment 5:

A kind of dark plum mulberry health-care wine, prescription:

With weight parts, prepare described dark plum mulberry health-care wine and comprise following raw material: Fructus Mume 140g, mulberry fruit 90g, sea-buckthorn 70g, Spina Date Seed 45g, rhizoma zingiberis 18g, banksia rose 18g, ginseng 14g, Radix Angelicae Sinensis 14g, Semen Cassiae 45g, N,O-Diacetylmuramidase 0.01g, the Shaoxing high-grade Shaoxing wine yellow rice wine 400g of 14 °.

Preparation method:

A, described Fructus Mume crushed after being dried is become 70 object dark plum powder, filter with after distilled water immersion 3h, after spin concentration, to obtain Fructus Mume extract for subsequent use in underpressure distillation; Cross 60 mesh sieves after being pulverized described Spina Date Seed, 75 DEG C with petroleum ether degreasing process after, use at 77 DEG C ethanol content be the ethanol extract refluxing extraction of 55% once, extraction time controls as 5h, elimination Slag recovering extracting solution, concentrated postlyophilization obtains Semen Ziziphi Spinosae extract, for subsequent use;

B, described mulberries, sea-buckthorn to be squeezed the juice respectively, obtain morisuccus and juice of Fructus Hippophae, for subsequent use;

C, described rhizoma zingiberis, the banksia rose, ginseng, Radix Angelicae Sinensis, Semen Cassiae to be pulverized respectively be 80 object powder, be that powder joins in described ethanol extract by 1:18 respectively according to feed liquid mass volume ratio, ultrasonic extraction is carried out twice respectively under 450W power, each extraction time is 30min, merging filtrate Rotary Evaporators concentrates and is placed on dry 12h in freeze drier and makes respective extract dry powder, for subsequent use;

D, the described extract obtained and squeezing juice are all added in the osmanthus wine of 12.5 ° and mixed, ferment 3 days at 40 DEG C of lower seals, normal temperature bottom fermentation adds lyase bacterium for 5 days and is finished product afterwards.

Clinical experiment:

1. the clinical experiment of strengthening spleen and nourishing stomach:

Dark plum mulberry health-care wine prepared by the scheme provided according to the embodiment of the present invention 1, carry out for weakness of the spleen and the stomach, the have loose bowels clinical experiment of illness for the treatment of is observed as follows:

Method: totally 50 routine patients, are divided into treatment group and control group at random, often organizes 25 examples, and the treatment of dark plum mulberry health-care wine prepared by the scheme that treatment group gives to drink the embodiment of the present invention 1 every day and provides, control group drinks commercially available health care wine for nourishing stomach, and the course for the treatment of is 30 days.

Having loose bowels is increase with times of defecation, even excrement matter thin as water sample be the common disease of main clinical manifestation, can be caused by many reasons, common weakness of the spleen and the stomach diseases, liver kidney discord disease and insufficiency of kidney-YANG disease, the most common with weakness of the spleen and the stomach diseases.

In March ,-2014 in March, 2012, contriver has carried out system clinical observation and nursing to weakness of the spleen and the stomach patient, specific as follows:

Object: be all the patient accepted for medical treatment in individual clinic, is divided into treatment group and control group at random, in treatment group 30 example, man 10 example, female 15 example, age 18-65 year, average 45 years old, course of disease 1-3, average 1.5 years; In control group 20 example, man 11 example, female 9 example, age 20-50 year, average 40 years old, course of disease 1-3, average 2 years.The basic document of two groups of patients compares without significant difference, has comparability.

Case definition:

Tcm diagnosis standard: weakness of the spleen and the stomach diseases, primary symptom: rush down time half congealed during stool, namely diet is careless slightly sends out or increases the weight of, pale tongue; Secondary disease: abdominal distention after meal, poor appetite, gastral cavity abdomen ruffian is full, fatigue and weakness, spiritlessness and sparing of words, white and thin fur, thready and weak pulse.

Methods for the treatment of:

Treatment group: give the dark plum mulberry health-care wine treatment that the embodiment of the present invention 1 provides, every day, everyone respectively drank once sooner or later, each 10mL.

Control group: the health promoting wine drunk is by cloves 15 grams, 15 grams, santal, the banksia rose 20 grams, fructus amomi 20 grams, honey 50 milliliters, the health promoting wine that low alcohol white spirit 1000 milliliters sealing immersion 2 week makes, every day, everyone respectively drank once sooner or later, each 10mL.

Over the course for the treatment of, diet should based on light, few greasy, light food, and can use vegetable soup, hot congee etc., not taking raw and cold foods, greasy and pungent stimulation food, avoid tobacco and wine for treatment group and control group.

Treatment result:

Curative effect judging standard: clinical recovery: times of defecation, amount and character recover normal, simultaneous phenomenon and sign disappear; 2. effective: times of defecation every day 2-3 time, be approximately shaped or loose stool every day 1 time, simultaneous phenomenon and sign are clearly better before comparatively treating; 3. effective: number of times and the character of stool take a favorable turn, and simultaneous phenomenon and sign take a turn for the better before comparatively treating to some extent; 4. invalid: not reach above-mentioned standard person.

Result: treatment group: clinical recovery 20 example, effective 5 examples, effective 5 examples, invalid 0 example, total effective rate 100%; Control group: clinical recovery 2 example, effective 3 examples, effective 4 examples, no effect 9, total effective rate 45%.

Brief summary: show according to this clinical treatment outcome, takes dark plum mulberry health-care wine provided by the invention, and coordinates meticulous diet nursing good results, and total effective rate reaches 100%, is worth applying individual patient.

And take the patient of dark plum mulberry health-care wine provided by the invention, after weakness of the spleen and the stomach symptom takes a turn for the better, continue to drink, its facial complexion by former dark and gloomy change into ruddy, weak transference cure, health obviously can feel freely comfortable, and Digestive tract keeps normal.

2. the clinical treatment experiment of chronic bronchitis:

Object: case is totally 100 examples, is the patient that individual clinic is accepted for medical treatment, wherein more than 60 years old have 23 routine, wherein oldest have 80 years old women, and what the age was minimum is 12 years old, women's case 32 example, in these cases, what the course of disease was the shortest is 1 year, and this some patients accounts for 20%, what the course of disease was the longest has 10 years, and what spring fell ill has 18 examples, 22 examples of morbidity in autumn, all the other are morbidity in winter example, according to total number of persons, patient is divided into 5 groups at random, often organizes 20 examples.

Case definition: draft as foundation according to " new Chinese medicine guideline of clinical investigations ", chronic bronchitis with repeated coughing, expectoration for cardinal symptom or with panting, annual morbidity continues 3 months, and continuous more than 2 years or 2 years, increase the weight of in the recent period, its symptom of breathing with cough is obvious, and the common chronic bronchitis emphysema of chest film inspection, gets rid of the other diseases with cough, expectoration, wheezing symptoms.

Methods for the treatment of:

Treatment group: front 4 groups in grouping, dark plum mulberry health-care wine prepared by the scheme that drinking embodiment of the present invention 2-5 successively respectively provides, takes night and morning, and each 10mL, takes 2 weeks continuously.

Control group: the 5th group, take ten taste shellfish sand and fall apart, warm water is taken after meal sooner or later, and each 5g, takes 2 weeks continuously.

Treatment result:

Criterion of therapeutical effect, according to the regulation of China's " basic diagnosis and treatment specification of common disease ", cures: cough, phlegm, breathe heavily cardinal symptom and sign complete incidence graph; Take a turn for the better: cough, phlegm, breathe heavily cardinal symptom and sign obviously alleviates; Do not heal: cough, phlegm, breathe heavily cardinal symptom and sign without being clearly better or increasing the weight of.

Curative effect: according to the Ureteral Calculus record to this 100 case, its data statistics is as following table 1:

Classification	Embodiment 2	Embodiment 3	Embodiment 4	Embodiment 5	Ten taste shellfish sand fall apart
						Grouping	1 group	2 groups	3 groups	4 groups	5 groups
Cure	8	7	7	6	10
						Take a turn for the better	7	10	8	11	6
Do not heal	5	3	5	3	4

Table 1

After 5 groups of case treatments, symptom, rabat improve situation and are compared as follows table 2:

Table 2

Be can clearly be seen that by above-mentioned contrast, dark plum mulberry health-care wine provided by the invention its in assisting therapy chronic bronchitis shape, there is curative effect quite well, and the ten taste shellfish sand that control group uses are loose has reasonably well effect for wheezing symptoms.

Although do not carry out experiment for the oxidation-resistance of dark plum mulberry health-care wine provided by the present invention and bacteriostasis property the present inventor to prove, rationally can derive it principle there is antioxidant property and fungistatic effect admirably.

The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. a dark plum mulberry health-care wine, it is characterized in that, with weight parts, prepare described dark plum mulberry health-care wine and comprise following raw material: Fructus Mume 100-150 part, mulberry fruit 60-100 part, sea-buckthorn 50-80 part, Spina Date Seed 30-50 part, rhizoma zingiberis 10-30 part, banksia rose 12-20 part, ginseng 10-15 part, Radix Angelicae Sinensis 10-15 part, Semen Cassiae 30-50 part, base wine 300-500 part.

2. a kind of dark plum mulberry health-care wine according to claim 1, it is characterized in that, with weight parts, prepare described dark plum mulberry health-care wine and comprise following raw material: Fructus Mume 120-140 part, mulberry fruit 70-90 part, sea-buckthorn 60-70 part, Spina Date Seed 35-45 part, rhizoma zingiberis 15-25 part, banksia rose 15-18 part, ginseng 12-14 part, Radix Angelicae Sinensis 11-14 part, Semen Cassiae 35-45 part, base wine 350-450 part.

3. a kind of dark plum mulberry health-care wine according to claim 1, it is characterized in that, with weight parts, prepare described dark plum mulberry health-care wine and comprise following raw material: Fructus Mume 130 parts, 80 parts, mulberry fruit, sea-buckthorn 65 parts, Spina Date Seed 40 parts, rhizoma zingiberis 20 parts, the banksia rose 16 parts, ginseng 13 parts, Radix Angelicae Sinensis 13 parts, Semen Cassiae 40 parts, base wine 400 parts.

4. a kind of dark plum mulberry health-care wine according to claim 1, is characterized in that, with weight parts, described raw material also comprises: N,O-Diacetylmuramidase 0.01-0.02 part.

5. a kind of dark plum mulberry health-care wine according to any one of claim 1-3, is characterized in that, described base wine is the fermented wine of the alcohol number of degrees≤20%.

6. prepare the method for a kind of dark plum mulberry health-care wine described in any one of claim 1-5, it is characterized in that, comprise the following steps:

A, the Fructus Mume of described number, Spina Date Seed to be purified respectively, obtain extract;

B, the mulberries of described number, sea-buckthorn to be squeezed the juice respectively, obtain morisuccus and juice of Fructus Hippophae;

C, the ethanol extract being 70-80% by the rhizoma zingiberis of described number, the banksia rose, ginseng, Radix Angelicae Sinensis, Semen Cassiae use ethanol content carry out ultrasonic extraction and obtain its extract respectively;

D, the described extract obtained and squeezing juice are all added in described base wine and mixed, at 30-40 DEG C of lower seal fermentation 2-3 days, normal temperature bottom fermentation 3-5 days is finished product afterwards.

7. the method for a kind of dark plum mulberry health-care wine of preparation according to claim 6, is characterized in that, in step a, the method extracting the extracting solution of described Fructus Mume and Spina Date Seed is specially:

Described Fructus Mume crushed after being dried is become 70-80 object dark plum powder, filter with after distilled water immersion 2-3h, after spin concentration, to obtain Fructus Mume extract for subsequent use in underpressure distillation;

50-60 mesh sieve is crossed after being pulverized by described Spina Date Seed, 70-80 DEG C with petroleum ether degreasing process after, the ethanol extract refluxing extraction using ethanol content to be 55-60% at 76-77 DEG C once, extraction time controls as 4-5h, elimination Slag recovering extracting solution, concentrated postlyophilization obtains Semen Ziziphi Spinosae extract.

8. the method for a kind of dark plum mulberry health-care wine of preparation according to claim 6, is characterized in that, in step c, the concrete grammar of ultrasonic extraction is:

The rhizoma zingiberis of described number, the banksia rose, ginseng, Radix Angelicae Sinensis, Semen Cassiae are pulverized respectively into 60-80 object powder, be that powder joins in described ethanol extract by 1:15-20 respectively according to feed liquid mass volume ratio, ultrasonic extraction is carried out twice respectively under 400-500W power, each extraction time is 20-30min, and merging filtrate Rotary Evaporators is concentrated to be placed on dry 10-12h in freeze drier and to make extract dry powder.

9. the method for a kind of dark plum mulberry health-care wine of preparation according to claim 8, is characterized in that, in described steps d, after 30-40 DEG C of lower seal fermentation 2-3 days, also comprises: the lyase bacterium adding described number, mixing.