CN101757386B

CN101757386B - Preparation method of traditional Chinese medicine for treating infantile capillary bronchitis

Info

Publication number: CN101757386B
Application number: CN2010101014766A
Authority: CN
Inventors: 于兵; 李恒东
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-01-27
Filing date: 2010-01-27
Publication date: 2011-05-11
Anticipated expiration: 2030-01-27
Also published as: CN101757386A

Abstract

The invention discloses a preparation method of a traditional Chinese medicine for treating infantile capillary bronchitis, belonging to the technical field of preparation methods of traditional Chinese medicines. Western medicine is used for treating infantile capillary bronchitis currently, but the western medicine has large side effects. The preparation method comprises the steps of: weighting white mulberry rood bark, gingko, honeysuckle, fructus forsythiae, Chinese violet, dandelion, folium isatidis, isatis root, patrinia, cordate houttuynia, pariphyllin, potentilla discolor, radix berberidis, sticktight, Japanese cayratia herb, unprepared rheum officinale, scutellaria baicalensis, goldthread, unprepared cape jasmine, platycodon grandiflorum and liquorice; soaking the other 20 traditional Chinese herbs of the prescription, except the unprepared rheum officinal, in 660 ml of water for 30 minutes; adding the unprepared rheum officinal after decocting by slow fire for 5 minutes and keeping decocting for 10 minutes; filtering dregs out of decoction and obtaining 100 ml of decoction, wherein the decoction is the traditional Chinese medicine for treating infantile capillary bronchitis. The invention has the advantages of simple process, and less toxic or side effect, and longlasting, stable and no-rebounding treatment effect of the prepared traditional Chinese medicine.

Description

A kind of preparation method of Chinese medicine for the treatment of infantile bronchiolitis

Technical field

The present invention relates to the Chinese medicinal preparation method technical field, is a kind of preparation method of Chinese medicine for the treatment of infantile bronchiolitis more specifically.

Background technology

The treatment infantile bronchiolitis generally adopts the method for western medicine at present.1, adopts promethazine, cause 1. xerostomia, nauseating, drowsiness easily; 2. intramuscular injection can cause local pain; 3. quiet notes can make blood pressure drops; 4. mental excitation and even mad dry on the contrary after the minority medication.2, adopt chlorpromazine, local excitation is strong, suitable deep intramuscular injection.Quiet quiet property vasculitis can take place, also see xerostomia is arranged, drowsiness, unable, nasal obstruction, bradycardia, blurred vision etc.3, adopt the succinic acid hydrocortisone can cause that hypertension, hypokalemia, hypochloremic alkalosis, peptic ulcer perforation are hemorrhage etc.4, adopt alpha-interferon, can cause 1. influenza-like symptom: common, symptoms such as heating, tired, shiver with cold, anorexia are arranged, be more common in heavy dose, when using in early days, prolong with administration time, incidence rate reduces, but drug withdrawal symptom complete obiteration after 1～2 day.2. gastrointestinal reaction: feel sick, vomiting, minority has diarrhoea, stomachache.3. neurological symptom: 1/3 patient is taken place, and drowsiness, abalienation is arranged, the appearance myalgia that has.4. a few patients has cardiovascular symptom, as hypotension, tachycardia etc.5. other: (leukocyte lowers, and relevant with dosage, minority has thrombocytopenia, and hemoglobin lowers for erythra, liver function injury (transaminase increases), haematics toxicity.)

Summary of the invention

For overcoming above-mentioned shortcoming, the objective of the invention is to invent a kind of preparation method of Chinese medicine for the treatment of infantile bronchiolitis.Infantile acute bronchitis is the acute bronchiolitis disease that is caused by the multiple former infection of causing a disease, and suppresses to breathe heavily, three depressions sign and be main clinical characters along ring.

Clinical manifestation: primary disease betides children's below 2 years old, and is most in 6 months.Breathe heavily to suppress and be its outstanding behaviours with the pulmonary wheezing sound.Mainly show as lower respiratory tract and block symptom, expiratory dyspnea occurs, expiratory phase prolongs the companion and stridulates.Dyspnea can be the paroxysmal intermission expiration disappearance of stridulating.The serious attack person, pale complexion, dysphoria, mouthful week and lip cyanosis.The whole body poisoning symptom is lighter, can not have heat, low grade fever, moderate heating, rare hyperpyrexia.Health check-up is found to breathe shallow and fast, and 60～80 times/minute, even 100 times/minute, companion's flaring of alaenasi and three depressions sign; Heart rate is accelerated, and can reach 150～200 times/minute.Pulmonary's sign is mainly wheezing sound, and percussion can be tympanitic resonance, breathe heavily suppress the catabasis audible and in, fine crackles.

Auxiliary examination: total white blood cells and classification are normal or higher mostly.Visible emphysema or the pulmonary atelectasis in various degree of X line breast examination also can be seen peribronchitis and increased bronchovascular shadows.Blood gas analysis can be understood infant anoxia and CO ₂The degree of retention.

Its technical scheme is: get Cortex Mori 3 weight portions, Semen Ginkgo 1 weight portion, Flos Lonicerae 6 weight portions, Fructus Forsythiae 2 weight portions, Herba Violae 3 weight portions, Herba Taraxaci 3 weight portions, Folium Isatidis 3 weight portions, Radix Isatidis 1 weight portion, Herba Patriniae 1 weight portion, Herba Houttuyniae 1 weight portion, Rhizoma Paridis 1 weight portion, Herba Potentillae Discoloris 1 weight portion, Radix Berberidis 1 weight portion, Herba Bidentis Bipinnatae 1 weight portion, Herba Cayatiae Japonicae 1 weight portion, Radix Et Rhizoma Rhei (back down) 1 weight portion, Radix Scutellariae 6 weight portions, Rhizoma Coptidis 3 weight portions, Fructus Gardeniae 3 weight portions, Radix Platycodonis 3 weight portions and Radix Glycyrrhizae 3 weight portions, in above-mentioned prescription, except that Radix Et Rhizoma Rhei, other 20 flavor medicine places 660 ml waters, soaked 30 minutes, slow fire is fried 15 minutes then, putting into Radix Et Rhizoma Rhei fried in shallow oil 10 minutes again, fried medical filtration remove slag 100 milliliters of medicinal liquids, the medicinal liquid that makes is the Chinese medicine of treatment infantile bronchiolitis.

The advantage of this invention is: pharmaceutical technology is simple, and the herbal toxic effect of making is little, with this medicine oral after, the curative effect lasting stability is difficult for bounce-back, medicine has been avoided 1, has been adopted promethazine in the digestive tract good absorbing, causes 1. xerostomia easily, feels sick, drowsiness; 2. intramuscular injection can cause local pain; 3. quiet notes can make blood pressure drops; 4. mental excitation and even mad dry on the contrary after the minority medication.2, adopt chlorpromazine, local excitation is strong, suitable deep intramuscular injection.Quiet quiet property vasculitis can take place, also see xerostomia is arranged, drowsiness, unable, nasal obstruction, bradycardia, blurred vision etc.3, adopt the succinic acid hydrocortisone can cause that hypertension, hypokalemia, hypochloremic alkalosis, peptic ulcer perforation are hemorrhage etc.4, adopt alpha-interferon, can cause 1. influenza-like symptom: common, symptoms such as heating, tired, shiver with cold, anorexia are arranged, be more common in heavy dose, when using in early days, prolong with administration time, incidence rate reduces, but drug withdrawal symptom complete obiteration after 1～2 day.2. gastrointestinal reaction: feel sick, vomiting, minority has diarrhoea, stomachache.3. neurological symptom: 1/3 patient is taken place, and drowsiness, abalienation is arranged, the appearance myalgia that has.4. a few patients has cardiovascular symptom, as hypotension, tachycardia etc.5. other: (leukocyte lowers, and relevant with dosage, minority has thrombocytopenia, and hemoglobin lowers for erythra, liver function injury (transaminase increases), haematics toxicity.) and make infantile bronchiolitis obtain recovery from illness.Cortex Mori, Semen Ginkgo, Flos Lonicerae, Fructus Forsythiae, Herba Violae, Herba Taraxaci, Folium Isatidis, Radix Isatidis, Herba Patriniae, Herba Houttuyniae, Rhizoma Paridis, Herba Potentillae Discoloris, Radix Berberidis, Herba Bidentis Bipinnatae, Herba Cayatiae Japonicae.More than 15 flavor medical instruments have analgesicly eliminate the phlegm, the merit of antiasthmatic-antitussive, heat-clearing and toxic substances removing.Cortex Mori wherein: sweet cold falling, the long purte the white of merit is to relieving asthma, and the row diseases caused by retention of fluid is with detumescence, and experiment confirm: Cortex Mori has good analgesic phlegm-dispelling functions.Semen Ginkgo: lowering the adverse-rising QI to relieve dyspnea, specially go into lung meridian, the gas of astringing the lung is relievingd asthma and is coughed.The sweet cold clear virtue of Flos Lonicerae, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance reach thoroughly and do not hold back heresy, can dispelling wind-heat, and again can removing summer-heat blood poison.Modern medicine study confirms: Flos Lonicerae contains Saponin, tannic acid, inosite etc.Flos Lonicerae Saponin energy regulate body temperature maincenter has refrigeration function, and the effect of detoxifcation, antiinflammatory is arranged.The experiment in vitro proof has extensive antibacterial action: staphylococcus aureus, Hemolytic streptococcus, Diplococcus pneumoniae, dysentery bacterium, Bacillus typhi etc. are all had stronger antibacterial action; Influenza virus there is certain inhibitory action; The Fructus Forsythiae and the eliminating stagnation of relieving inflammation or internal heat, all diseases of pyretic toxicity, normal and Flos Lonicerae mutual reinforcement between adapteds controlled; Herba Violae is held concurrently and can be subsided a swelling; The double energy of Herba Taraxaci liver heat removing and eyesight improving; The cooling blood and dissolving purpura of the double energy of Folium Isatidis; The double energy of Radix Isatidis removing heat from blood; The evacuation of pus of the double energy of Herba Patriniae clots absorbing; The double energy of Herba Houttuyniae subduing inflammation, inducing diuresis for treating stranguria syndrome; The double energy of flea body mass dissipating and swelling eliminating, diuresis; The cooling blood for hemostasis of the double energy of Herba Potentillae Discoloris; The double energy of Radix Berberidis bowel relieving dysentery relieving; The double energy of Herba Bidentis Bipinnatae promoting blood circulation to remove blood stasis, bowel relieving antidiarrheal; Herba Cayatiae Japonicae is held concurrently, and the energy removing heat from blood is subsided a swelling, diuresis.More than 15 flavor medical instruments have analgesicly eliminate the phlegm, the effect of lowering the adverse-rising QI to relieve dyspnea, heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, removing heat from blood, in treatment infantile bronchiolitis process, play main therapeutical effect, so be monarch drug.Radix Et Rhizoma Rhei (back down), Radix Scutellariae, Rhizoma Coptidis, the equal bitter in the mouth of this 4 flavor medicine of Fructus Gardeniae are cold in nature, and the merit of clearing heat, purging intense-heat is all arranged.Wherein the sedimentation of Radix Et Rhizoma Rhei bitter cold, abnormal smells from the patient are all thick, and power is apt to away suddenly, and the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels that can go directly is cleansed gastrointestinal retention, rushes down the blood system excess-heat clearly.Lung and large intestine are shown reason mutually, and Radix Et Rhizoma Rhei bowel relieving relieving constipation, eliminating fire and detoxication have the meaning of " treating disease in the upper by managing the lower victory ".The double energy of Radix Scutellariae heat clearing and damp drying, clearing heat and preventing abortion, heat clearing away blood pressure lowering.Radix Scutellariae is longer than part of the body cavity above the diaphragm housing the heart and lungs heat clearly.Modern medicine study confirms: it is peaceful etc. that Radix Scutellariae contains baicalin, baicalein and Radix Scutellariae.Effects such as that Radix Scutellariae has is analgesic, diuresis, antibiotic, antiviral, antifungal, calmness and blood pressure lowering.In vitro tests: Radix Scutellariae has stronger antibacterial action to dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, staphylococcus, Hemolytic streptococcus, Diplococcus pneumoniae etc.The double energy of Rhizoma Coptidis heat clearing and damp drying, detoxifcation doctor skin ulcer; The relieving restlessness of the double energy of Fructus Gardeniae, dampness removing, cooling blood for hemostasis.Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis, this 4 flavor medical instrument of Fructus Gardeniae have the merit of clearing heat, purging intense-heat, bowel relieving relieving constipation, cooling blood for hemostasis, in the process of treatment infantile bronchiolitis, can assist principal agent performance therapeutical effect, so be ministerial drug.Radix Platycodonis: bitter, hot, flat.Go into lung meridian.Lung qi dispersing eliminates the phlegm, removing pus and relieving carbuncle.Radix Platycodonis is lung meridian edema caused by disorder of QI medicine, specially goes into lung meridian.Toil is flat, both rises and falls, and is good at the dispersing and elevation lung qi, the fast diaphragm of a surname's breast, expelling phlegm for arresting cough.Can treat the disease of infantile capillary tracheitis.Be good at the dispersing and elevation lung qi, all medicines of rate are up, and through focus is so be adjuvant drug.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.Can entangle the bias of all medicines, can alleviate the toxicity of all medicines again, so be messenger drug.Cortex Mori, Semen Ginkgo, Flos Lonicerae, Fructus Forsythiae, Herba Violae, Herba Taraxaci, Folium Isatidis, Radix Isatidis, Herba Patriniae, Herba Houttuyniae, Rhizoma Paridis, Herba Potentillae Discoloris, Radix Berberidis, Herba Bidentis Bipinnatae, Herba Cayatiae Japonicae, Radix Et Rhizoma Rhei (back down), Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Platycodonis, Radix Glycyrrhizae.More than 21 flavor medicine compatibilities use, play jointly analgesicly eliminate the phlegm, the effect of lowering the adverse-rising QI to relieve dyspnea, heat-clearing and toxic substances removing, clearing away heat-fire, dispersing swelling and dissipating binds, bowel relieving relieving constipation, monarch, compatibility is proper, is the optimum formula of treatment infantile bronchiolitis.Cortex Mori: sweet, cold.Go into lung meridian.Eliminating pathogen from the lung for relieving asthma, line water detumescence.Semen Ginkgo: sweet, bitter, puckery, flat, slightly poisonous.Go into lung meridian, fall the expectorant Dingchuan, the leukorrhagia stopping turbidity removal.Flos Lonicerae: sweet, cold.Go into lung, the heart, stomach warp.Heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.Fructus Forsythiae: hardship is slightly cold.Go into the heart, small intestine meridian.Heat-clearing and toxic substances removing, the eliminating stagnation of relieving inflammation or internal heat.Herba Violae: bitter, hot, cold.Go into the heart, Liver Channel.Heat-clearing and toxic substances removing.Herba Taraxaci: bitter, sweet, cold.Go into liver, stomach warp.Heat-clearing and toxic substances removing, liver heat removing and eyesight improving.Folium Isatidis: bitter, salty, Great Cold.Go into the heart, stomach warp.Heat-clearing and toxic substances removing, cooling blood and dissolving purpura.Radix Isatidis: hardship, cold.Go into the heart, stomach warp.Clearing away heat,cooling blood and removing toxin.Herba Patriniae: suffering, hardship is slightly cold.Go into stomach, large intestine, Liver Channel.Heat-clearing and toxic substances removing, the clots absorbing evacuation of pus.Herba Houttuyniae: suffering is slightly cold.Go into lung, kidney, urinary bladder channel.Separate pyretic toxicity, subduing inflammation, inducing diuresis for treating stranguria syndrome.Rhizoma Paridis: little hardship, cold, slightly poisonous.Go into Liver Channel.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Herba Potentillae Discoloris; Sweet, little hardship, flat.Go into liver, spleen, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis.Radix Berberidis: hardship, cold.Go into lung, liver, large intestine channel.Heat-clearing and toxic substances removing, the bowel relieving dysentery relieving.Herba Bidentis Bipinnatae: hardship is slightly cold.Go into lung, famous scenic spot, stomach, large intestine channel.Heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, bowel relieving antidiarrheal.Herba Cayatiae Japonicae: sour, bitter, cold.Go into liver, spleen, urinary bladder channel.Heat-clearing and toxic substances removing, removing heat from blood detumescence, diuresis.Radix Et Rhizoma Rhei (back is down): hardship, cold.Go into stomach, large intestine, spleen, liver, pericardium channel.The bowel relieving relieving constipation, eliminating fire and detoxication, eliminating blood stasis and inducing menstruation.Radix Scutellariae: bitter, cold.Go into lung, intestine and small intestine, spleen, gallbladder meridian.Clearing heat, purging intense-heat, heat clearing and damp drying, clearing heat and preventing abortion, heat clearing away blood pressure lowering.Rhizoma Coptidis: bitter, cold.Go into the heart, stomach, liver, gallbladder, large intestine channel.Clearing heat, purging intense-heat, heat clearing and damp drying, detoxifcation doctor skin ulcer.Fructus Gardeniae: hardship, cold.Go into the heart, liver, lung, stomach, tri-jiao channel.The pathogenic fire purging relieving restlessness, the dampness removing that expels the heat-evil, cooling blood for hemostasis.Radix Platycodonis: bitter, hot, flat.Go into lung meridian.Lung qi dispersing eliminates the phlegm, removing pus and relieving carbuncle.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.Spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.

The specific embodiment

Get Cortex Mori 3g, Semen Ginkgo 1g, Flos Lonicerae 6g, Fructus Forsythiae 2g, Herba Violae 3g, Herba Taraxaci 3g, Folium Isatidis 3g, Radix Isatidis 1g, Herba Patriniae 1g, Herba Houttuyniae 1g, Rhizoma Paridis 1g, Herba Potentillae Discoloris 1g, Radix Berberidis 1g, Herba Bidentis Bipinnatae 1g, Herba Cayatiae Japonicae 1g, Radix Et Rhizoma Rhei (back down) 1g, Radix Scutellariae 6g, Rhizoma Coptidis 3g, Fructus Gardeniae 3g, Radix Platycodonis 3g and Radix Glycyrrhizae 3g, in above 21 flavor medicines, except that Radix Et Rhizoma Rhei, place 660 ml waters, soaked 30 minutes, slow fire is fried 15 minutes then, putting into Radix Et Rhizoma Rhei fried in shallow oil 10 minutes again, fried medical filtration remove slag 100 milliliters of medicinal liquids, the medicinal liquid that makes is the Chinese medicine of treatment infantile bronchiolitis.Allow children's obey 5 milliliters, three times on the one, five is a course of treatment at every turn, if symptom is still deposited, obeys for second course of treatment again, until recovery from illness.

The range of age of table one, 335 routine infantile bronchiolitis patients

Age (moon)	6～10	11～15	16～20	21～24
					The example number	2	5	217	111
Percentage ratio %	0.60	1.49	64.78	33.13

Table two, 335 routine infantile bronchiolitis patient curative effect tables

	Cure	Take a turn for the better	Invalid
				The example number	332	3	0
Percentage ratio %	99.1	0.9	0

Table three, 335 routine infantile bronchiolitis patients show the course of treatment

The treatment natural law	2	3～5	6～9	10～14
					The example number	1	2	307	25
Percentage ratio %	0.3	0.6	91.64	7.46

Information slip before and after table four, the 335 routine infantile bronchiolitis patients

Claims

1. preparation method of Chinese medicine for the treatment of infantile bronchiolitis, it is characterized in that: get Cortex Mori 3 weight portions, Semen Ginkgo 1 weight portion, Flos Lonicerae 6 weight portions, Fructus Forsythiae 2 weight portions, Herba Violae 3 weight portions, Herba Taraxaci 3 weight portions, Folium Isatidis 3 weight portions, Radix Isatidis 1 weight portion, Herba Patriniae 1 weight portion, Herba Houttuyniae 1 weight portion, Rhizoma Paridis 1 weight portion, Herba Potentillae Discoloris 1 weight portion, Radix Berberidis 1 weight portion, Herba Bidentis Bipinnatae 1 weight portion, Herba Cayatiae Japonicae 1 weight portion, Radix Et Rhizoma Rhei 1 weight portion, Radix Scutellariae 6 weight portions, Rhizoma Coptidis 3 weight portions, Fructus Gardeniae 3 weight portions, Radix Platycodonis 3 weight portions and Radix Glycyrrhizae 3 weight portions, in above-mentioned prescription, except that Radix Et Rhizoma Rhei, other 20 flavor medicine places 660 ml waters, soaked 30 minutes, slow fire is fried 15 minutes then, putting into Radix Et Rhizoma Rhei fried in shallow oil 10 minutes again, fried medical filtration remove slag 100 milliliters of medicinal liquids, the medicinal liquid that makes is the Chinese medicine of treatment infantile bronchiolitis.