CN104547021A - Compound motherwort herb mixture as well as preparation method and application thereof in treatment of gynecological diseases - Google Patents
Compound motherwort herb mixture as well as preparation method and application thereof in treatment of gynecological diseases Download PDFInfo
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- CN104547021A CN104547021A CN201410832720.4A CN201410832720A CN104547021A CN 104547021 A CN104547021 A CN 104547021A CN 201410832720 A CN201410832720 A CN 201410832720A CN 104547021 A CN104547021 A CN 104547021A
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- herba leonuri
- extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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Abstract
The invention relates to a compound motherwort herb preparation as well as a preparation method and application thereof in treatment of gynecological diseases. The traditional Chinese medicine compound preparation contains active ingredients of motherwort herb and astragalus that are extracted by atmospheric pressure microwave-assisted extraction, wherein active substances of motherwort herb and astragalus are extracted by an atmospheric pressure microwave-assisted extraction method. According to the invention, the compound motherwort herb preparation has good effect on the treatment of gynecological diseases; the preparation method has the advantages of high extraction efficiency, full extraction, good reproducibility and less solvent consumption.
Description
Technical field
The present invention relates to field of Chinese herbal, be specifically related to a kind of compound recipe Herba Leonuri mixture for the treatment of gynaecopathia and preparation method thereof quality gynaecopathia is applied.
Background technology
Herba Leonuri is gynecological's common medicine, has blood circulation promoting and blood stasis dispelling, and regulating menstruation, disappear the effects such as water.
The Radix Astragali is important resistance and supplementing qi medicine, has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.
The prescription that Herba Leonuri and the Radix Astragali share is more.Herba Leonuri and the Radix Astragali are mutual-assistance medicine pair, and phase envoy refer to based on Herba Leonuri, and the Radix Astragali is auxiliary, action compensating, to improve effect of principal agent Herba Leonuri.Herba Leonuri is pungent and can manage it, and micro-hardship can be let out, micro-cold prevailing over heat, and kind energy clots absorbing is stagnant, and clearing away heat from blood, the water that disappears wets, and is gynecological's good medicine." distinguishing medicine guide " carries " to be entered liver and clearing heat to evacuate, specially to control before tire all diseases in puerperal, therefore named Herba Leonuri.Before all tires, gas is easily stagnant, therefore malignant histocytosis and tire is uneasy.Puerperal, blood was easily stagnant, therefore bruise and suffering from abdominal pain.Do not push away with this blood-activating and qi-promoting and swing, vim and vigour being dredged with except stagnating, go a long way cloudy point, therefore cloud having the merit of nourishing YIN." Radix Astragali sweet in the mouth temperature yellow skin, soil in tonification, replenishing vital QI with drugs of warm nature taste, yang invigorating consolidating superficial resistance, all middle gas is depressed, and spleen soil is weak, and the person of sinking is the most suitable for clearing heat in QI system." solar corona all book on Chinese herbal medicine " carries " help gas, strengthening bone and muscle, put on flesh, enrich blood ... control metrorrhagia, leukorrhagia ".The mutual-assistance is matched, make Radix Astragali tonifying Qi and lifting yang and the fraud that helpless hear rate the moon is detained, all can use for all diseases of the deficiency of vital energy folder stasis of blood, especially the bad caused lochia of pure uterine contraction in puerperal is suitable for, reposition of the womb is incomplete, the disease such as bacteriological infection of prevention metrorrhagia, or the gynecopathy therapeutic such as menorrhagia, or women's general debility with deficiency of QI, all diseases of simulataneous insufficiency and excessive rehabilitation there is good effect.
The invention provides a kind of Chinese medicine compound Herba Leonuri mixture for the treatment of gynaecopathia, only comprise the compound recipe Herba Leonuri mixture of Herba Leonuri and the Radix Astragali two taste Chinese medicine, Herba Leonuri and the Radix Astragali feed intake in proportion, and apply normal pressure microwave auxiliary extraction method effective component extracting, then carry out vacuum concentration, vacuum drying, micronizing, then carry out formulation application.
Instant invention overcomes three outstanding problems containing Herba Leonuri prescription of clinical practice:
1. prescription Chinese medicine kind is many, and compatibility is complicated;
2. preparation method is simple, and active component is fuzzy, with low content of technology;
3. incapsulate use with decocting decoction or simple pulverizing, be unfavorable for giving full play to of active component drug effect in raw material.
Compound recipe Herba Leonuri mixture of the present invention is for puerpera's postpartum recovery and gynaecopathia.
Summary of the invention
The invention provides a kind of Chinese medicine compound Herba Leonuri mixture and preparation method thereof and the application at treatment gynaecopathia, compound recipe Herba Leonuri mixture of the present invention, material combination is simple, and be easy to get, drug effect is high.
The technical solution used in the present invention is as follows:
A kind of compound recipe Herba Leonuri mixture, it is characterized in that, its effective ingredient is made up of the superfine powder of Herba Leonuri extract and superfine powder two kinds of components of Radix Astragali extract, and the mass ratio of the two is
10:1 ~ 1:10.
The mass ratio of the superfine powder of described Herba Leonuri extract and the superfine powder of Radix Astragali extract is
3:1 ~ 1:3.
The preparation method of described compound recipe Herba Leonuri mixture, is characterized in that:
(1) superfine powder of Herba Leonuri extract is prepared: normal pressure microwave auxiliary extraction extracts Herba Leonuri active component → vacuum concentration, vacuum drying obtains Herba Leonuri dry extract → employing air-flow micronizing method, Herba Leonuri dry extract is ground into the superfine powder of Herba Leonuri extract, particle diameter≤20 μm;
(2) superfine powder of Radix Astragali extract is prepared: normal pressure microwave auxiliary extraction extracts Radix Astragali active component → vacuum concentration, vacuum drying obtains Radix Astragali dry extract → employing air-flow micronizing method, Radix Astragali Mongolici dry extractum powder is broken into the superfine powder of Radix Astragali extract, particle diameter≤20 μm;
(3) Herba Leonuri dry extract superfine powder and Radix Astragali dry extract superfine powder are mixed in proportion, technique makes the one in granule, capsule, tablet, oral liquid, unguentum routinely.
The application of compound recipe Herba Leonuri mixture in treatment gynaecopathia.
1) prescription of compound recipe Herba Leonuri mixture is Herba Leonuri and the Radix Astragali two taste Chinese medicine, both meets theory of Chinese medical science, and meet again modern pharmacy research, experimental index shows it and has definite therapeutical effect.
2) adopt normal pressure microwave auxiliary extraction method, extract Herba Leonuri and Radix Astragali active component.
This method tool has the following advantages:
1. extraction efficiency is high, extraction is abundant, favorable reproducibility, consumption solvent are few;
2. the device structure selected is tightly reasonable, and operation controls accurately, easily to reach the parameter designed;
3. environmental pollution is few.
3) when concentrated extracting solution, vacuum concentration technology is adopted.When preparing dry extract, have employed vacuum drying technique.Both improve production efficiency, and be conducive to again ensuring drug quality.
4) one of active component that Herba Leonuri is important is leonurine, be insoluble in water, dissolubility is only 1% ~ 2%, before being prepared into various preparation, micronization processes has been carried out to Herba Leonuri dry extract and Radix Astragali dry extract, micronization can improve dissolubility and the dissolution of insoluble medicine, and because specific surface area increases, moistening level strengthens.Micronization processes, is more conducive to the absorption of medicine.When carrying out micronizing, use the method for air-flow micronizing, successful is better than mill formula micronizing method, and can realize the particle diameter of less than 20 μm.
5) the present invention mainly applies three aspects:
1. gynaecopathia metrorrhagia, menorrhagia is treated, and rehabilitation after being ill.
2. treat puerpera's reposition of the womb in puerperal incomplete, prevent posthemorrhagic bacteriological infection and recovery of lying-in woman.
3. women's general debility with deficiency of QI, all diseases of simulataneous insufficiency and excessive is treated.
Compound recipe Herba Leonuri mixture of the present invention, only comprise the compound recipe Herba Leonuri mixture of Herba Leonuri and the Radix Astragali two taste Chinese medicine, Herba Leonuri and the Radix Astragali feed intake in proportion, and apply normal pressure microwave auxiliary extraction method effective component extracting, then carry out vacuum concentration, vacuum drying, micronizing, then carry out formulation application.
Instant invention overcomes three outstanding problems containing Herba Leonuri prescription of clinical practice:
1. prescription Chinese medicine kind is many, and compatibility is complicated;
2. preparation method is simple, and active component is fuzzy, with low content of technology;
3. incapsulate use with decocting decoction or simple pulverizing, be unfavorable for giving full play to of active component drug effect in raw material.
Compound recipe Herba Leonuri mixture of the present invention is for puerpera's postpartum recovery and gynaecopathia.
In micropowder preparation process, different micronizing methods, crushing effect is variant, and air-flow micronizing method is applicable to the micronizing being applied to Herba Leonuri and Radix Astragali extract, and its superfine powder has better mobility and result of extraction.
In vitro in Dissolution experiments, Herba Leonuri, Radix Astragali extract superfine powder (≤20 μm), under simulated gastric fluid condition, have better result of extraction than common flour (crossing 200 mesh sieves), with astragaloside and leonurine for index components, add up stripping at 60min and exceed
75%.
The present invention, in pharmacodynamic experiment, constructs different animal models, and carry out experimentation, result shows, the Radix Astragali and Herba Leonuri extract superfine powder share, and have good drug effect.The novelty of the present invention and novelty mainly contain following several respects.
(1) prescription of compound recipe Herba Leonuri mixture is Herba Leonuri and the Radix Astragali two taste Chinese medicine, both meets theory of Chinese medical science,
Meet again modern pharmacy research, experimental index shows it and has definite therapeutical effect.
(2) adopt normal pressure microwave auxiliary extraction method to the extraction of Herba Leonuri active substance and Radix Astragali active substance, this method tool has the following advantages: extraction efficiency is high, extraction is abundant, favorable reproducibility, consumption solvent are few; The device structure selected is tightly reasonable, and operation controls accurately, easily to reach the parameter designed; Environmental pollution is few.
(3) adopt vacuum concentration technology when concentrated extracting solution, have employed vacuum drying technology when preparing dry extract, both improve
Production efficiency, is conducive to again ensuring drug quality.
(4) before being prepared into various preparation, micronization processes has been carried out to Herba Leonuri dry extract and Radix Astragali dry extract, has more been conducive to
The absorption of medicine.When carrying out micronizing, the successful of air-flow micronizing method is used to be better than mill formula micronizing method,
And the particle diameter of less than 20 μm can be realized.
(5) the present invention mainly applies three aspects:
1. gynaecopathia metrorrhagia, menorrhagia is treated.
2. treating maternal uterine resets incomplete, prevents posthemorrhagic bacteriological infection and postpartum recovery etc.
3. women's general debility with deficiency of QI, all diseases of simulataneous insufficiency and excessive is treated.
Detailed description of the invention
embodiment 1.
The preparation method of compound recipe Herba Leonuri mixture
1) Herba Leonuri active component extracts: normal pressure microwave auxiliary extraction.
1. Herba Leonuri is crushed to
2 ~10 mm particle diameters, are immersed in the water 2h, after filtering water, add cyclohexane extraction-alcohol mixed solvent, adopt normal pressure microwave auxiliary extraction (microwave wavelength 1mm ~ 1m, frequency 300 ~ 300000MHZ).Extraction time 15 min.
2. be separated removing medicinal residues, obtain extracting solution, be the extractum of 1.21 ~ 1.25 by extracting solution vacuum concentration below 60 DEG C to relative density, then add Nulomoline, mix homogeneously, vacuum concentration obtains dry extract.
3. adopt air-flow micronizing method, Herba Leonuri dry extract is pulverized, particle diameter
≤20 μm.
2) Radix Astragali active component extracts: normal pressure microwave auxiliary extraction.
1. the Radix Astragali is crushed to 2 ~ 10 mm particle diameters, is immersed in the water 2h, after filtering water, add cyclohexane extraction-alcohol mixed solvent, adopt normal pressure microwave auxiliary extraction (microwave wavelength 1mm ~ 1m, frequency 300 ~ 300000MHZ).Extraction time 15 min.
2. be separated removing medicinal residues, obtain extracting solution, extracting solution vacuum concentration below 60 DEG C is greater than 1.2 to relative density, then adds Nulomoline in extractum, mix homogeneously, vacuum concentration obtains dry extract.
3. air-flow micronizing method is adopted, Radix Astragali Mongolici dry extractum powder is broken, particle diameter≤20 μm.
According to calculating ratio by Herba Leonuri dry extract micropowder and Radix Astragali dry extract micropowder mix homogeneously, make oral solid formulation: tablet or capsule or granule.Also can be made into syrup or oral liquid.
embodiment 2.
Microwave Assisted Extraction Technique and traditional extraction process comparative experiments are studied
Microwave Assisted Extraction Technique has carried out augmentation of heat transfer, mass transfer on traditional extraction technique basis, and experiment embodies microwave-assisted extraction technique and has the advantages such as extraction efficiency is high, favorable reproducibility, consumption solvent are few, equipment simple, processing ease, and extraction is abundant, pollution is few.
The extraction that Microwave Assisted Extraction Technique is applied to active substance in medium-height grass the effective elements of the medicine and plant cell is a new application.The experimental result that Microwave Assisted Extraction Technique compares with conventional extraction process sees the following form.
Table 1. Microwave Assisted Extraction Technique compares with conventional extraction process
Embodiment 3.
Compound recipe Herba Leonuri tablet dissolution determination
The particle diameter of medicine and surface area are the medicines of the key factor affecting solid orally ingestible dissolution, identical weight, and particle diameter is less, and surface area is larger, are more beneficial to stripping.
1. compound recipe Herba Leonuri tablet dissolution determination chooses the sample that two kinds of differences prepare dry extract method:
1) normal pressure microwave auxiliary extraction extraction Herba Leonuri and Radix Astragali active component → vacuum concentration, vacuum drying obtain dry extract → employing air-flow micronizing method, Herba Leonuri dry extract and Radix Astragali Mongolici dry extractum powder are broken into superfine powder, particle diameter≤20 μm.
2) Herba Leonuri of chopping and the Radix Astragali are infiltrated → use water as in water solvent decoction extraction to obtain extracting solution → vacuum concentration, vacuum drying 3 times, pulverized 200 mesh sieves, obtain Herba Leonuri and Radix Astragali dry extract.Particle diameter about 75 μm.
2. the sample that two kinds of differences prepare dry extract method makes tablet respectively
3. the dissolution of the compound recipe Herba Leonuri tablet that sample that two kinds of differences prepare dry extract method is made respectively is measured according to the dissolution determination method (first method) of States Pharmacopoeia specifications.The results are shown in Table 2.
The compound recipe YIMUCAO PIAN dissolution that table 2. adopts present invention process to prepare and prepared by employing traditional handicraft
(astragaloside and leonurine are index components accumulative dissolution)
Can obviously find out from table 2, the dissolution of the tablet that the tablet that present invention process obtains obtains than traditional method improves a lot.
Embodiment 4.
Compound recipe Herba Leonuri mixture pharmacological experiment study
1. zoopery obviously can find out that compound recipe Herba Leonuri mixture has a significant effect to uterus weight
(according to weight ratio, the weight proportion of Herba Leonuri dry extract superfine powder and Radix Astragali dry extract superfine powder is: 1:1)
With female adult mouse subcutaneous injection diethylstilbestrol oil preparation 1.65 μ g/10g, every day 1 time, continuous 3 days.Respectively gavage compound recipe Herba Leonuri mixture (weight proportion of Herba Leonuri dry extract superfine powder and Radix Astragali dry extract superfine powder is: 1:1), continuous 7 days, experiment show compound recipe Herba Leonuri mixture can make uterine wet weight and dry weight comparatively matched group obviously alleviate.Administration group uterine wet weight and dry weight are respectively 319 ± 29.3mg/100g body weight and 65.2 ± 3.4mg/100g body weight; Matched group is respectively 625 ± 86mg/100g body weight and 120.1 ± 23.1mg/100g body weight.
2. animal experiment study shows that compound recipe Herba Leonuri mixture strengthens uterine myometrium, and uterus vigor strengthens.
Table 3. Herba Leonuri mixture is on the impact of normal unpregnancy Mouse Uterus
(weight proportion of Herba Leonuri dry extract superfine powder and Radix Astragali dry extract superfine powder is experiment compound recipe Herba Leonuri mixture: 1:1), result shows that Herba Leonuri mixture makes normal unpregnancy Mouse Uterus smooth muscle contraction frequency accelerate, contraction intensity is without significant change, and uterine motility slightly strengthens; Postpartum mice uterine myometrium frequency is significantly accelerated, and contraction intensity is enhancing trend, thus makes uterine motility significantly strengthen.
Table 4. Herba Leonuri mixture is on the impact in postpartum mice uterus
Claims (4)
1. a compound recipe Herba Leonuri mixture, is characterized in that, its effective ingredient is made up of the superfine powder of Herba Leonuri extract and superfine powder two kinds of components of Radix Astragali extract, and the mass ratio of the two is 10:1 ~ 1:10.
2. compound recipe Herba Leonuri mixture according to claim 1, is characterized in that: the mass ratio of the superfine powder of described Herba Leonuri extract and the superfine powder of Radix Astragali extract is 3:1 ~ 1:3.
3. the preparation method of compound recipe Herba Leonuri mixture according to claim 1, is characterized in that:
(1) superfine powder of Herba Leonuri extract is prepared: normal pressure microwave auxiliary extraction extracts Herba Leonuri active component → vacuum concentration, vacuum drying obtains Herba Leonuri dry extract → employing air-flow micronizing method, Herba Leonuri dry extract is ground into the superfine powder of Herba Leonuri extract, particle diameter≤20 μm;
(2) superfine powder of Radix Astragali extract is prepared: normal pressure microwave auxiliary extraction extracts Radix Astragali active component → vacuum concentration, vacuum drying obtains Radix Astragali dry extract → employing air-flow micronizing method, Radix Astragali Mongolici dry extractum powder is broken into the superfine powder of Radix Astragali extract, particle diameter≤20 μm;
(3) Herba Leonuri dry extract superfine powder and Radix Astragali dry extract superfine powder are mixed in proportion, technique makes the one in granule, capsule, tablet, oral liquid, unguentum routinely.
4. the application of compound recipe Herba Leonuri mixture according to claim 1 in treatment gynaecopathia.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434199A (en) * | 2018-06-19 | 2018-08-24 | 泸州德高生物科技有限公司 | The preparation method of beneficial female red paste nourishing agent |
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| CN1857607A (en) * | 2006-03-02 | 2006-11-08 | 四川泰华堂制药有限公司 | Chinese medicine preparation for treating cardiac and cerebral vascular diseases and its preparing process |
| CN103816423A (en) * | 2014-03-12 | 2014-05-28 | 潘国栋 | Compound medicine composition for treating metrorrhagia |
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2014
- 2014-12-29 CN CN201410832720.4A patent/CN104547021A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1724000A (en) * | 2004-07-22 | 2006-01-25 | 孙毅 | Injection for treating cardiovascular and cerebrovascular diseases, and its prepn. method |
| CN1857607A (en) * | 2006-03-02 | 2006-11-08 | 四川泰华堂制药有限公司 | Chinese medicine preparation for treating cardiac and cerebral vascular diseases and its preparing process |
| CN103816423A (en) * | 2014-03-12 | 2014-05-28 | 潘国栋 | Compound medicine composition for treating metrorrhagia |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434199A (en) * | 2018-06-19 | 2018-08-24 | 泸州德高生物科技有限公司 | The preparation method of beneficial female red paste nourishing agent |
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