CN105194299A - Application of traditional Chinese medicine composition in preparation of medicines for treating cerebral thrombosis - Google Patents
Application of traditional Chinese medicine composition in preparation of medicines for treating cerebral thrombosis Download PDFInfo
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Abstract
The invention discloses an application of a traditional Chinese medicine composition in preparation of medicines for treating cerebral thrombosis, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials: radix ophiopogonis, angelica sinensis, notopterygium, pseudo-ginseng, flos carthami, poria cocos, white peony root, ligusticum wallichii, artemisia anomala, earthworms and liquorice. The traditional Chinese medicine composition has the efficacies of nourishing yin, tonifying the kidneys, replenishing essence, benefiting blood, breaking stagnation and eliminating blood stasis, and also has the advantages of being simple in preparation technology, good in curative effect, low in side effect, convenient to take, easy to popularize and apply and the like.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to the purposes of a kind of Chinese medicine composition in preparation treatment cerebral thrombosis medicine.
Background technology
The traditional Chinese medical science is thought: the formation of cerebral thrombosis belongs to " apoplexy " category, its sick position of cerebral thrombosis at brain, its cause of disease roughly nothing more than " wind, fire, expectorant, void, the stasis of blood " for suffer from.According to relevant record, the differentiation of symptoms and signs for classification of syndrome of clinical treatment primary disease roughly can be controlled from following four type opinions:
1, Qi deficiency blood stasis type: how because positive QI-insufficiency, the deficiency of vital energy can not transport blood, system blood, causes blood must not be flourish, and blood stasis venation, brain is become homeless and supported and thrombosis.Disease sees hemiplegia, disabled wilted limbs, or single limb need not, facial hemiparalysis, stiff tongue language be puckery, and have dizzy, shortness of breath and palpitation, uncomfortable in chest, face is dark or sallow, limb is soft weak, enlarged tongue and purple, or has ecchymosis point, and stringy and thready pulse is unable or heavy thin and puckery;
2, phlegm and blood stasis, numbness resistance venation type: the expectorant stasis of blood is the core pathogenesis forming apoplexy, covers fertile people's excessive phlegm, the strongly fragrant and heat-dissipating of phlegm-damp, hear rate body fluid, gradually hinders venation.Or spleen deficiency generating phlegm, or water general be expectorant, or phlegm-fire in contain.The lid stasis of blood is the key of hemiplegia, have blood stasis due to qi deficiency be subject to cold coagulation puckery or be heated decoct into the stasis of blood point, clinical all should examine card and control.Clinical common hemiplegia, numb limbs and tense tendons, facial hemiparalysis, headache agitation, Light-headedness, cough up phlegm not well, tongue be dark red, tongue greasy, stringy and thready pulse and slide, control and work as eleminating phlegm and freeing channels in vain;
3, the hepatic and renal YIN deficiency, liver-Yang sthenia type: clinical common hemiplegia, facial hemiparalysis, aphasia, have that dizzy, headache, flushed face with red ears, bitter taste in the mouth and dry throat, susceptible to lose temper due to restlessness, dark coloured urine dry stool, pale tongue with thin fur are yellow, stringy and thready pulse concurrently.Controlling suppressing the hyperactive liver and subsiding YANG, calming wind and dredging collateral to be method, and side selects Zhengan Xifeng Tang add and subtract, see as double irritated insomnia, vertigo and tinnitus, feverish sensation in the palms and soles, time have night sweat, crimson tongue red or dark red, lack tongue or no fur, thready and stringy pulse or stringy and thready pulse number, control when nourishing YIN relieves dizziness, high fever, infantile convulsions, epilepsy, etc.;
4, the empty damage of essence of marrow, the hollow type of venation: lid deficiency of the liver and kindey then marrow Tianjin blood can not on give in brain, brain is become homeless department, for a long time then dizzy vertigo, one's ears rang and spots danced before one's eyes, even amaurosis or blind; Or emit mind dusk, limbs contracture; Or numb hemiplegia, the askew language of mouth is not smoothgoing, soreness of waist and knee, and flushed complexion cold foot, deep red tongue, yellow fur dry mouth, deep pulse are counted accurately, controls when nourishing YIN and supplementing the kidney, replenishing essence benefit blood.
The medicine of current western medical treatment cerebral thrombosis mainly contains the medicines such as blood vessel dilating agent, depressor and anti-platelet aggregation agent, and these side effects of pharmaceutical drugs are comparatively large, and life-time service can bring injury in various degree to human organ.Traditional Chinese medical science thrombolytic therapy energy blood circulation promoting and blood stasis dispelling, dredging brain arteries and veins, and toxic and side effects is little, not easily recurs after controlling, accept by most patient, but also there is the problem that curative effect is slow, the course for the treatment of is long.
Chinese patent application 200810079760.0 discloses a kind of Chinese medicine composition for cerebral thrombosis, comprises following raw materials: Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, the Radix Angelicae Dahuricae, Poria, Radix Rehmanniae, Radix Scutellariae, Eupolyphaga Seu Steleophaga, Flos Carthami, Pheretima, Scorpio, Herba Asari and Radix Glycyrrhizae Preparata.Though this Chinese medicine composition has certain curative effect to cerebral thrombosis, but required taste of Chinese medicine number is more, and preparation technology is more complicated.
Summary of the invention
The technical problem to be solved in the present invention is to provide the purposes of a kind of Chinese medicine composition in preparation treatment cerebral thrombosis medicine, and this Chinese medicine composition has significant blood stasis dispelling blood effect, can be used for treating cerebral thrombosis.In addition, the present invention also provides the corresponding preparation method of described Chinese medicine composition.
The Chinese medicine composition that the present invention relates to is prepared from by the raw material of following parts by weight:
Radix Ophiopogonis 10-15 part, Radix Angelicae Sinensis 6-12 part, Rhizoma Et Radix Notopterygii 3-10 part, Radix Notoginseng 3-10 part, Flos Carthami 3-10 part, Poria 10-15 part, Radix Paeoniae Alba 6-15 part, Rhizoma Chuanxiong 3-10 part, Herba Artemisiae Anomalae 5-10 part, Pheretima 4-10 part and Radix Glycyrrhizae 1-10 part.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight:
Radix Ophiopogonis 10 parts, Radix Angelicae Sinensis 6 parts, Rhizoma Et Radix Notopterygii 3 parts, Radix Notoginseng 3 parts, 3 parts, Flos Carthami, 10 parts, Poria, the Radix Paeoniae Alba 6 parts, Rhizoma Chuanxiong 3 parts, Herba Artemisiae Anomalae 5 parts, Pheretima 4 parts and 1 part, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight:
Radix Ophiopogonis 15 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Notoginseng 10 parts, 10 parts, Flos Carthami, 15 parts, Poria, the Radix Paeoniae Alba 15 parts, Rhizoma Chuanxiong 10 parts, Herba Artemisiae Anomalae 10 parts, Pheretima 10 parts and 10 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight:
Radix Ophiopogonis 12 parts, Radix Angelicae Sinensis 8 parts, Rhizoma Et Radix Notopterygii 6 parts, Radix Notoginseng 6 parts, 6 parts, Flos Carthami, 12 parts, Poria, the Radix Paeoniae Alba 10 parts, Rhizoma Chuanxiong 6 parts, Herba Artemisiae Anomalae 8 parts, Pheretima 6 parts and 6 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is made into capsule, granule, tablet or drop pill.
Accordingly, the present invention also provides the preparation method of described Chinese medicine composition, comprises following step:
(1): take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40-50% is the alcoholic solution of 60-85%, and regulation and control carbon dioxide flow is 15-20L/h, and extracting pressure is 15-20MPa, extraction temperature is 40-60 DEG C, extraction time is 1-3h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
(2): take Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Notoginseng, Flos Carthami, Poria, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Artemisiae Anomalae, Pheretima and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, add the alcoholic solution of the 60-85% of medical material 4-8 times weight, reflux, extract, 2 times, each 6-12h, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60-70 DEG C of relative density be the concentrated solution of 1.15-1.25, obtain alcohol extraction concentrated solution;
(3): by described Radix Ophiopogonis extract and the mixing of described alcohol extraction concentrated solution, vacuum belt type drying is carried out at 50-60 DEG C of temperature, drying pressure is-0.09MPa, charging rate is 12-18L/h, material strip transfer rate is 20-28cm/min, after drying, dry extract is pulverized, cross 100-200 mesh sieve, obtain Chinese medicine composition of the present invention.
Source, the nature and flavor of Chinese medicine composition of the present invention component used, return through and effect:
Radix Ophiopogonis: this product is the tuber of liliaceous plant Radix Ophiopogonis, Hubei Radix Ophiopogonis, short Roripa mountain wheat or Radix Liriopes, dwarf lilyturf etc.; Sweet in the mouth, micro-hardship, cold in nature; GUIXIN, lung, stomach warp; YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and improves immunity, blood sugar lowering.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving.
Rhizoma Et Radix Notopterygii: this product is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii; Acrid in the mouth, hardship; Warm in nature; Return bladder, kidney channel; Cold expelling, dispels the wind, dehumidifying, pain relieving.
Radix Notoginseng: this product is the dry root of panax araliaceae plant; Sweet in the mouth, micro-hardship, warm in nature; Return liver, stomach warp; Dissipating blood stasis stops blooding, subduing swelling and relieving pain.
Flos Carthami: this product is the dried floral of feverfew Flos Carthami; Acrid in the mouth, warm in nature; GUIXIN, Liver Channel; Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.
Poria: this product is the dry sclerotia of On Polyporaceae Poria; Sweet in the mouth, light, property is put down; GUIXIN, lung, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae; Bitter in the mouth, acid, cold nature; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation.
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.
Herba Artemisiae Anomalae: this product is the herb of feverfew artemisia anomalas; Acrid in the mouth, micro-hardship; GUIXIN, liver, spleen channel; Dissipating blood stasis to promote menstruationg, hemostasia and detumescence.
Pheretima: this product is the dry body of Ju Yin section animal Pheretima aspergillum, popular Pheretimatschiliensis, power simulation or the blind Pheretimatschiliensis of comb; Salty in the mouth, cold in nature; Return liver, spleen, urinary bladder channel; Heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, Chinese medicine composition provided by the invention has following beneficial effect:
1, the invention provides the purposes of a kind of Chinese medicine composition in preparation treatment cerebral thrombosis medicine, involved Chinese medicine composition significantly can reduce the liver coefficient of blood stasis model rat, the whole blood that can also reduce blood stasis model rat is high cuts relative indices, the low cut index of whole blood, erythrocyte aggregation index and plasma viscosity, effective blood stasis symptom improving rat, has significant blood stasis dispelling blood effect.
2, compared with the chemotherapeutic agent of Current therapeutic cerebral thrombosis, Chinese medicine composition provided by the invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and Chinese medicine composition effect provided by the invention is comprehensive, and medication effect is better.
3, Chinese medicine composition provided by the invention also has that compatibility science, preparation technology are simple, good effect, side effect are low, taking convenience and be easy to advantages such as applying.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
the preparation of embodiment 1 Chinese medicinal composition capsules agent of the present invention
The embodiment of the present invention 1 Chinese medicine composition is prepared from by the raw material of following parts by weight:
Radix Ophiopogonis 10 parts, Radix Angelicae Sinensis 6 parts, Rhizoma Et Radix Notopterygii 3 parts, Radix Notoginseng 3 parts, 3 parts, Flos Carthami, 10 parts, Poria, the Radix Paeoniae Alba 6 parts, Rhizoma Chuanxiong 3 parts, Herba Artemisiae Anomalae 5 parts, Pheretima 4 parts and 1 part, Radix Glycyrrhizae.
Preparation method is as follows:
(1): take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40% is the alcoholic solution of 75%, and regulation and control carbon dioxide flow is 15L/h, and extracting pressure is 15MPa, extraction temperature is 40 DEG C, extraction time is 1h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
(2): take Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Notoginseng, Flos Carthami, Poria, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Artemisiae Anomalae, Pheretima and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, add the alcoholic solution of 75% of medical material 4 times of weight, reflux, extract, 2 times, each 6h, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.15, obtain alcohol extraction concentrated solution;
(3): by described Radix Ophiopogonis extract and the mixing of described alcohol extraction concentrated solution, vacuum belt type drying is carried out at 50 DEG C of temperature, drying pressure is-0.09MPa, charging rate is 12L/h, material strip transfer rate is 20cm/min, after drying, dry extract is pulverized, cross 200 mesh sieves, obtain Chinese medicine composition of the present invention;
(4): in the Chinese medicine composition of gained, add adjuvant wetting agent distilled water and binding agent carmethose, the amount ratio of fine powder and wetting agent, binding agent is 1:0.3:0.5, prepare soft material processed, cross nylon mesh to granulate, dry at 70 DEG C, in incapsulating, obtain the capsule of Chinese medicine composition of the present invention.
the preparation of embodiment 2 Chinese medicine composition pill agent of the present invention
The embodiment of the present invention 2 Chinese medicine composition is prepared from by the raw material of following parts by weight:
Radix Ophiopogonis 15 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Notoginseng 10 parts, 10 parts, Flos Carthami, 15 parts, Poria, the Radix Paeoniae Alba 15 parts, Rhizoma Chuanxiong 10 parts, Herba Artemisiae Anomalae 10 parts, Pheretima 10 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is as follows:
(1): take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40% is the alcoholic solution of 75%, and regulation and control carbon dioxide flow is 15L/h, and extracting pressure is 15MPa, extraction temperature is 40 DEG C, extraction time is 1h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
(2): take Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Notoginseng, Flos Carthami, Poria, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Artemisiae Anomalae, Pheretima and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, add the alcoholic solution of 75% of medical material 4 times of weight, reflux, extract, 2 times, each 6h, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.15, obtain alcohol extraction concentrated solution;
(3): by described Radix Ophiopogonis extract and the mixing of described alcohol extraction concentrated solution, vacuum belt type drying is carried out at 50 DEG C of temperature, drying pressure is-0.09MPa, charging rate is 12L/h, material strip transfer rate is 20cm/min, after drying, dry extract is pulverized, cross 200 mesh sieves, obtain Chinese medicine composition of the present invention;
(4): the water-soluble base Macrogol 2000 adding Chinese medicine composition weight 6 times in the Chinese medicine composition of gained, mix homogeneously, heating, emulsifying obtains medicinal liquid, puts into pill dripping machine and makes drop, adds the condensed fluid liquid paraffin of fine powder weight 1/5, obtained pellet, wherein, condensed fluid and substrate are not miscible, after drop pill molding, removing liquid paraffin, and dry arrangement, carry out quality inspection, after qualified on inspection, packaging, obtains the drop pill of Chinese medicine composition of the present invention.
the preparation of embodiment 3 Chinese medicinal composition capsules agent of the present invention
The embodiment of the present invention 3 Chinese medicine composition is prepared from by the raw material of following parts by weight:
Radix Ophiopogonis 12 parts, Radix Angelicae Sinensis 8 parts, Rhizoma Et Radix Notopterygii 6 parts, Radix Notoginseng 6 parts, 6 parts, Flos Carthami, 12 parts, Poria, the Radix Paeoniae Alba 10 parts, Rhizoma Chuanxiong 6 parts, Herba Artemisiae Anomalae 8 parts, Pheretima 6 parts and 6 parts, Radix Glycyrrhizae.
Preparation method is as follows:
(1): take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 45% is the alcoholic solution of 75%, and regulation and control carbon dioxide flow is 18L/h, and extracting pressure is 18MPa, extraction temperature is 50 DEG C, extraction time is 2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
(2): take Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Notoginseng, Flos Carthami, Poria, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Artemisiae Anomalae, Pheretima and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, add the alcoholic solution of 75% of medical material 6 times of weight, reflux, extract, 2 times, each 10h, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.20, obtain alcohol extraction concentrated solution;
(3): by described Radix Ophiopogonis extract and the mixing of described alcohol extraction concentrated solution, at 50 DEG C of temperature, carry out vacuum belt type drying, drying pressure is-0.09MPa, charging rate is 15L/h, and material strip transfer rate is 22cm/min, is pulverized by dry extract after drying, cross 200 mesh sieves, obtain Chinese medicine composition;
(4): in the Chinese medicine composition of gained, add adjuvant wetting agent distilled water and binding agent carmethose, the amount ratio of fine powder and wetting agent, binding agent is 1:0.3:0.5, prepare soft material processed, cross nylon mesh to granulate, dry at 70 DEG C, in incapsulating, obtain the capsule of Chinese medicine composition of the present invention.
chinese medicine composition of the present invention is to the improvement result of rat blood stasis models
1, laboratory animal and grouping: get 72 female SPF SD rats, 18-20 week age, body weight 250-300g, is divided into 9 groups at random, often organize 8.
2, Experimental agents:
Blank group: gavage gives isopyknic normal saline;
Model group: gavage gives isopyknic normal saline;
Positive controls: XUESAITONG PIAN (Kunming Pharmaceutical Group Jintaide Pharmaceutical Co., Ltd., the accurate word Z53021554 of traditional Chinese medicines), grinds, with the suspension of water furnishing 60%, for subsequent use; By the dosage gastric infusion of 8.0g/kg;
Treatment A group: the Chinese medicinal composition capsules agent that the embodiment of the present invention 1 is obtained, is deployed into water the suspension that concentration is 60%, 40% and 20%, for subsequent use; Get 3 groups of mices, be labeled as high dose group (12.0g/kg), middle dosage group (8.0g/kg) and low dose group (4.0g/kg) respectively;
Treatment B group: the Chinese medicinal composition capsules agent that the embodiment of the present invention 3 is obtained, is deployed into water the suspension that concentration is 60%, 40% and 20%, for subsequent use; Get 3 groups of mices, be labeled as high dose group (12.0g/kg), middle dosage group (8.0g/kg) and low dose group (4.0g/kg).
3, experimental technique: to each group of rat gastric infusion respectively, once a day, administration the 13rd day, 14 days, except Normal group, all the other treated animals press 1mg/kg subcutaneous injection adrenalin hydrochloride, 2 times/day, interval 6h, after first time injection, animal is put into 15min in 0-4 DEG C of frozen water by 2h.Administration is got 4-5ml blood anticoagulant heparin on the 15th day and is measured blood rheology parameter, gets liver and to weigh conversion organ coefficient.
4, experimental result: as shown in table 1, table 2.
Table 1 is on the impact of rat blood stasis models liver coefficient
Note: compared with model group,
*p < 0.01; Compared with positive controls,
#p < 0.05,
##p < 0.01.
Liver coefficient result statistics display, compared with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high significantly reduce liver coefficient (
p< 0.01), positive controls compared with model group, also can reduce significantly liver coefficient (
p< 0.01).Compared with positive controls, the high dose group for the treatment of B group and middle dosage group have significant difference (
p< 0.05), the high dose group for the treatment of A group have significant difference (
p< 0.05).
Table 2 is on the impact of rat blood stasis models lectin from hemolymph
Note: compared with model group,
*p < 0.01; Compared with positive controls
#p < 0.05,
##p < 0.01.
As shown in Table 2, compared with model group, high relative indices, the low cut index of whole blood, erythrocyte aggregation index and the plasma viscosity cut of the whole blood of Chinese medicine composition of the present invention high, medium and low dosage group all significantly reduces, have pole significance difference (
p< 0.01), the whole blood of positive controls is high cut relative indices, the low cut index of whole blood, erythrocyte aggregation index and plasma viscosity also all significantly reduce (
p< 0.01); Compare with positive controls, rat whole blood is high cuts better effects if in relative indices, the low cut index of whole blood, erythrocyte aggregation index and plasma viscosity in reduction for Chinese medicine composition object height of the present invention, middle dosage group.
Visible, Chinese medicine composition of the present invention in blood stasis removing with more excellent compared with existing medicine in reduction liver coefficient.Can not transport blood and logical blood because cerebral thrombosis is many because of positive QI-insufficiency, the deficiency of vital energy, cause blood must not be molten, blood stasis venation, brain be become homeless and is supported and thrombosis, is therefore one of primary treatment principle according to theory of Chinese medical science blood circulation promoting and blood stasis dispelling.This experiment adopts the method establishment of subcutaneous injection adrenalin hydrochloride animal model with blood stasis, the symptom of simulation human body cerebral thrombosis, and by research Chinese medicine composition of the present invention to the improvement result of rat blood stasis models, draws its effect in blood stasis dispelling.Found by research, Chinese medicine composition of the present invention has good therapeutical effect for the blood stasis situation of rat, visible, and Chinese medicine composition of the present invention has significant effect in treatment cerebral thrombosis.
clinical observation on the therapeutic effect
1, case selection: in 300 routine cerebral thrombosis clinical volunteers patients, male volunteers patient 180 example, female volunteers patient 120 example, age bracket is 40-69 year, mean age is 53 years old, all patients all has typical cerebral thrombosis symptom, and in sex, age, the course of disease no difference of science of statistics.
2, efficacy assessment standard:
Cure--sign recovers normal, and clinical symptoms disappears substantially, can independent ambulation, takes care of oneself;
Effective--sign recovers normal substantially, and clinical symptoms major part disappears, can independent walking, and living section is taken care of oneself;
Effectively--clinical symptoms and sign partial disappearance, support can be stood, and can't take care of oneself;
Invalid--clinical symptoms and sign, without improvement, also have the trend worsened;
Total effective rate=(cure+effective+effectively)/total number of cases × 100%.
3, instructions of taking: 300 volunteer patients are divided into 3 groups at random, often organize 100 people, be respectively treatment A group, treatment B group and matched group, treatment A group and the treatment capsule that B component does not take the embodiment of the present invention 1, embodiment 3 prepares, every day 3 times, each 4; Matched group takes Xueshuan xinmaining Tablet (the accurate word Z20030145 of traditional Chinese medicines), every day 3 times, each 2, serve on 3 months.
4, therapeutic outcome: as shown in table 3.
Table 3 therapeutic outcome
This test adopts Xueshuan xinmaining Tablet as a control group, Xueshuan xinmaining Tablet has benefiting QI for activating blood circulation, pain relieving of having one's ideas straightened out, blood circulation promoting and blood stasis dispelling, causing resuscitation with aromatic drugs, blood fat reducing anticoagulant effect, for ischemic cardio cerebrovascular diseases such as cerebral infarction (cerebral thrombosis, cerebral embolism, multiple cerebral infarction, lacunar infarction), by comparing with the therapeutic effect of Chinese medicine composition of the present invention, can find out that the curative effect of traditional Chinese medicine composition for treating cerebral thrombosis aspect of the present invention is more remarkable.As shown in Table 3, the cure rate more than 75% of Chinese medicine composition of the present invention, total effective rate reaches 90%, higher than cure rate and the total effective rate of matched group, wherein best with the therapeutic effect for the treatment of B group, visible, the good effect of Chinese medicine composition of the present invention, cure rate is high, can be used as the drug use for the treatment of cerebral thrombosis.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (6)
1. the purposes of a Chinese medicine composition in preparation treatment cerebral thrombosis medicine, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Radix Ophiopogonis 10-15 part, Radix Angelicae Sinensis 6-12 part, Rhizoma Et Radix Notopterygii 3-10 part, Radix Notoginseng 3-10 part, Flos Carthami 3-10 part, Poria 10-15 part, Radix Paeoniae Alba 6-15 part, Rhizoma Chuanxiong 3-10 part, Herba Artemisiae Anomalae 5-10 part, Pheretima 4-10 part and Radix Glycyrrhizae 1-10 part.
2. the purposes of Chinese medicine composition as claimed in claim 1 in preparation treatment cerebral thrombosis medicine, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Radix Ophiopogonis 10 parts, Radix Angelicae Sinensis 6 parts, Rhizoma Et Radix Notopterygii 3 parts, Radix Notoginseng 3 parts, 3 parts, Flos Carthami, 10 parts, Poria, the Radix Paeoniae Alba 6 parts, Rhizoma Chuanxiong 3 parts, Herba Artemisiae Anomalae 5 parts, Pheretima 4 parts and 1 part, Radix Glycyrrhizae.
3. the purposes of Chinese medicine composition as claimed in claim 1 in preparation treatment cerebral thrombosis medicine, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Radix Ophiopogonis 15 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Notoginseng 10 parts, 10 parts, Flos Carthami, 15 parts, Poria, the Radix Paeoniae Alba 15 parts, Rhizoma Chuanxiong 10 parts, Herba Artemisiae Anomalae 10 parts, Pheretima 10 parts and 10 parts, Radix Glycyrrhizae.
4. the purposes of Chinese medicine composition as claimed in claim 1 in preparation treatment cerebral thrombosis medicine, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Radix Ophiopogonis 12 parts, Radix Angelicae Sinensis 8 parts, Rhizoma Et Radix Notopterygii 6 parts, Radix Notoginseng 6 parts, 6 parts, Flos Carthami, 12 parts, Poria, the Radix Paeoniae Alba 10 parts, Rhizoma Chuanxiong 6 parts, Herba Artemisiae Anomalae 8 parts, Pheretima 6 parts and 6 parts, Radix Glycyrrhizae.
5. the purposes of Chinese medicine composition as claimed in claim 1 in preparation treatment cerebral thrombosis medicine, is characterized in that: described Chinese medicine composition is made into capsule, granule, tablet or drop pill.
6. the purposes of the Chinese medicine composition as described in any one of claim 1-4 in preparation treatment cerebral thrombosis medicine, it is characterized in that, the preparation method of described Chinese medicine composition comprises following step:
(1): take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40-50% is the alcoholic solution of 60-85%, and regulation and control carbon dioxide flow is 15-20L/h, and extracting pressure is 15-20MPa, extraction temperature is 40-60 DEG C, extraction time is 1-3h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
(2): take Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Notoginseng, Flos Carthami, Poria, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Artemisiae Anomalae, Pheretima and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, add the alcoholic solution of the 60-85% of medical material 4-8 times weight, reflux, extract, 2 times, each 6-12h, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60-70 DEG C of relative density be the concentrated solution of 1.15-1.25, obtain alcohol extraction concentrated solution;
(3): by described Radix Ophiopogonis extract and the mixing of described alcohol extraction concentrated solution, vacuum belt type drying is carried out at 50-60 DEG C of temperature, drying pressure is-0.09MPa, charging rate is 12-18L/h, material strip transfer rate is 20-28cm/min, after drying, dry extract is pulverized, cross 100-200 mesh sieve, obtain Chinese medicine composition of the present invention.
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Application publication date: 20151230 |