CN110755501A

CN110755501A - Traditional Chinese medicine composition for treating diabetic peripheral neuropathy

Info

Publication number: CN110755501A
Application number: CN201911202410.3A
Authority: CN
Inventors: 杨辰华
Original assignee: HENAN PROVINCE CHINESE MEDICINE RESEARCH INSTITUTE
Current assignee: HENAN PROVINCE CHINESE MEDICINE RESEARCH INSTITUTE
Priority date: 2019-11-29
Filing date: 2019-11-29
Publication date: 2020-02-07

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating diabetic peripheral neuropathy, which comprises the following raw materials in parts by weight: 13-18 parts of eucommia bark, 18-23 parts of parasitic loranthus, 18-23 parts of medicinal cyathula root, 4-8 parts of cassia twig, 2-5 parts of asarum, 18-23 parts of radix rehmanniae recen, 18-23 parts of astragalus root, 10-15 parts of angelica, 7-12 parts of red peony root, 4-8 parts of mix-fried ephedra herb, 23-27 parts of earthworm, 5-8 parts of liquorice and 8-12 parts of centipede. Under the guidance of the theory of traditional Chinese medicine, the kidney tonifying and collateral dredging medicine is added on the basis of the angelica sinensis Sini decoction by optimizing the prescription combination, the curative effect is obviously improved, the blood running condition of a patient can be effectively improved, and the recovery of the nerve function is promoted, wherein eucommia ulmoides, parasitic loranthus and radix cyathulae in the prescription are used for tonifying liver and kidney and strengthening bones and muscles; ramulus Cinnamomi, herba asari, and herba Ephedrae have effects of warming channel, expelling cold, and dredging channels and collaterals; radix rehmanniae has the effects of nourishing yin and cooling blood and restricting dryness of cassia twig and asarum; astragalus root, Chinese angelica root, red peony root for supplementing qi and activating blood circulation; the liquorice is used for harmonizing the medicines and has the effects of tonifying qi, tonifying the kidney, removing blood stasis and dredging collaterals.

Description

Traditional Chinese medicine composition for treating diabetic peripheral neuropathy

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating diabetic peripheral neuropathy.

Background

Diabetic Peripheral Neuropathy (DPN) is a neuropathy caused by metabolic and microvascular lesions due to chronic hyperglycemia, and is characterized clinically by symmetric or asymmetric numbness, tingling, burning, formication, hypoesthesia or loss of socks-like sensation in both lower limbs, and hyporeflexion or disappearance of achilles tendons and knee tendons. DPN has the characteristics of high morbidity, early appearance time, more clinical symptoms, difficult disease spreading and the like, and brings great mental and physical pains to patients. Because the pathogenesis is unclear, no specific treatment method exists at present. DPN is a common chronic complication of diabetics, the pathogenesis of the DPN is not completely clarified, the clinical manifestations mainly appear at the earliest in sensory neuropathy, and also involve other nervous systems of motor nerves and vegetative nerves, the main symptoms are pain, numbness, nerve dysfunction and dyskinesia of limbs, and the quality of life and the life span of the diabetics are seriously influenced. The main pathological basis of DPN is hyperglycemia caused by diabetes, and is currently believed to be mainly associated with factors such as metabolic abnormal mechanisms, microangiopathy, advanced glycosylation endproducts, nitration reaction, endoplasmic reticulum stress, oxidative stress and mitochondrial dysfunction, deficiency of growth factors (N F), inflammatory response, and the like. The Western medicine mainly treats DPN according to symptoms such as blood sugar control, risk factor control, neuropathy blockage, microcirculation improvement, pain control and the like.

Clinically, the fact that DPN is mostly seen in the middle and later stages of disease development is observed, and the theory accords with the traditional Chinese medicine theory of 'chronic disease and kidney' and 'chronic disease and stasis', although the clinical manifestations of DPN are complex and changeable, the affected parts of DPN are mainly lower limbs, except common symptoms such as numbness, pain and muscular atrophy, the DPN also has the kidney deficiency manifestations such as soreness and weakness of waist and knees, intolerance of cold and cold limbs, impotence of men and female hyposexuality, and the theory accords with the theory of 'house of waist and kidney of people', 'below waist and knee and kidney qi of traditional Chinese medicine'. DPN is mostly caused by long course of disease, or poor disease control, prolonged course of disease, gradual aggravation of kidney deficiency, insufficient functions of various organs, incapability of promoting blood circulation, slow blood flow, blood stasis in veins and pain caused by obstruction of collaterals; laboratory examination finds that the rheological property of the blood of a patient is abnormal, the blood is viscous, the deformability of red blood cells is reduced, the platelet aggregation is enhanced, the microcirculation perfusion is insufficient, and the like, namely invisible stasis. In conclusion, the modern pharmacological research results are combined, the prescription combination is optimized under the guidance of the above thought, and the kidney tonifying and collateral dredging medicine is added on the basis of the angelica sinensis Sini decoction, so that the curative effect is obviously improved. The results of the invention show that the hemorheological indexes, TCSS scores and the conduction speeds of the peroneal nerve and the tibial nerve of the patients in the traditional Chinese medicine group after treatment are all superior to those in the conventional group (P is less than 0.05)), and the traditional Chinese medicine composition has a good curative effect on treating diabetic peripheral neuropathy, can effectively improve the blood running condition of the patients, promotes the recovery of nerve functions, improves the symptoms and physical signs of the patients, and is worthy of popularization and application.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide a traditional Chinese medicine composition for treating diabetic peripheral neuropathy, which is characterized in that under the guidance of the theory of traditional Chinese medicine, the modern pharmacological research results are combined, and the kidney tonifying and collateral dredging medicine is added on the basis of the angelica Sini decoction by optimizing the prescription combination, so that the curative effect is obviously improved, the blood running condition of a patient can be effectively improved, the recovery of nerve function is promoted, and the symptoms and physical signs of the patient are improved.

The invention aims to provide a traditional Chinese medicine composition for treating diabetic peripheral neuropathy, which comprises the following raw materials in parts by weight: 13-18 parts of eucommia bark, 18-23 parts of parasitic loranthus, 18-23 parts of medicinal cyathula root, 4-8 parts of cassia twig, 2-5 parts of asarum, 18-23 parts of radix rehmanniae recen, 18-23 parts of astragalus root, 10-15 parts of angelica, 7-12 parts of red peony root, 4-8 parts of mix-fried ephedra herb, 23-27 parts of earthworm, 5-8 parts of liquorice and 8-12 parts of centipede.

Preferably, the traditional Chinese medicine composition for treating diabetic peripheral neuropathy comprises the following raw materials in parts by weight: 15 parts of eucommia bark, 20 parts of parasitic loranthus, 20 parts of medicinal cyathula root, 6 parts of cassia twig, 3 parts of asarum, 20 parts of radix rehmanniae recen, 20 parts of astragalus, 12 parts of angelica, 9 parts of red paeony root, 6 parts of mix-fried ephedra herb, 25 parts of earthworm, 6 parts of liquorice and 10 parts of centipede.

Preferably, the medicinal dosage form of the traditional Chinese medicine composition for treating diabetic peripheral neuropathy is granules.

The effects and pharmacological actions of the raw material medicines are as follows:

1. eucommia ulmoides: pungent and mild in flavor and entering kidney meridian. The Shennong Ben Cao Jing records that the Chinese herbal medicine has the effects of relieving pain in the loins and back, invigorating spleen and replenishing vital essence, strengthening muscles and bones, strengthening the mind, eliminating pruritus and dampness under yin and residual urine. The compendium of materia Medica records: eucommia bark.

2. Parasitic loranthus: bitter, sweet and neutral in nature, enter liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, remove wind-damp, dredge meridians, nourish blood, prevent abortion. It is used to treat soreness of waist and knees, atrophy and weakness of tendons and bones, hemiplegia, tinea pedis, arthralgia due to wind-cold-dampness, fetal leakage, metrorrhagia, and puerperal agalactia. Has effects in nourishing liver and kidney, strengthening muscle and bone, and dredging channels and collaterals.

3. Radix cyathulae: it enters liver and kidney meridians with mild flavor and sour taste. Shen nong Ben Cao Jing: "bitter in taste". It can be used for treating arthralgia due to cold-dampness, spasm of limbs, and pain of knee joint; the materia Medica is in the future: "tonify liver and kidney, purge blood and cause various herbs to descend". It has effects in nourishing liver and kidney, and strengthening tendons and bones; ramulus Euonymi, bitter and cold in flavor, enters liver meridian and has the effects of breaking blood and dredging meridians.

4. Cassia twig: pungent and sweet in flavor, warm in nature, entering lung, heart and bladder meridians. To warm and dredge meridians, Ben Cao Xin (renewal of materia Medica): the Chinese medicinal composition has the effects of warming middle energizer, promoting blood circulation, invigorating spleen, drying stomach, relieving swelling, promoting diuresis, inducing sweat, expelling pathogenic factors from muscles, warming and activating meridians, supporting yang, regulating qi, and calming the adverse-rising energy.

5. Asarum: pungent and warm in nature and taste; the efficacy is as follows: dispel wind, dispel cold, move water and induce resuscitation. The asarum herb can not only disperse wind-cold externally, but also dispel yin-cold internally and relieve pain at the same time.

6. Dried rehmannia root: sweet, bitter and cold in nature and taste. It enters heart, liver and kidney meridians. Has the effects of clearing heat, cooling blood, nourishing yin and promoting the production of body fluid. Shen nong Ben Cao Jing: "mainly turn over and fall down the tendon, hurt the middle, dispel blood arthralgia, fill in bone marrow, grow muscle, as decoction to remove cold and heat accumulation, remove arthralgia. Good for the life.

7. Astragalus root: modern pharmacology proves that astragalus membranaceus can dilate blood vessels, improve blood circulation and enhance immunity of organisms.

8. Chinese angelica: sweet, pungent and warm in nature. It enters liver, heart and spleen meridians. Has effects in replenishing blood, regulating menstruation, promoting blood circulation, relieving pain, and loosening bowel to relieve constipation.

9. Red peony root: bitter and slightly cold in flavor, entering liver meridian. Shen nong Ben Cao Jing: peony, radix Paeoniae, is bitter and neutral in taste. It is mainly used for treating abdominal pain due to pathogenic qi, removing blood stagnation, resolving hard mass, eliminating cold and heat, relieving hernia, and relieving pain … … Shengchuangu. The herbal Zhenzhen: red peony root, radix Paeoniae Rubra is specialized in liver and has the effect of dispersing pathogenic factors and promoting blood circulation. Has the effects of clearing heat, cooling blood, promoting blood circulation and removing blood stasis.

10. Roasting ephedra: pungent, slightly bitter and warm in nature. It enters lung and bladder meridians. It has effects of inducing sweat, dispelling cold, dispersing lung qi, relieving asthma, inducing diuresis, and relieving swelling.

11. Earthworm: salty in nature and cold in flavor. It enters liver, spleen and bladder meridians. Has effects of clearing heat, arresting convulsion, dredging collaterals, relieving asthma, and promoting urination.

12. Licorice root: neutral in nature and sweet in flavor, it enters twelve meridians. Tonify spleen and qi, nourish cough and moisten lung, relieve urgency and detoxify, and harmonize various medicines. Unprocessed can be used for mainly treating swollen sore throat, deep-rooted carbuncle, pyocutaneous disease, gastrointestinal ulcer, drug toxicity removal, food poisoning and the like; stir-baked with honey is mainly indicated for hypofunction of spleen and stomach, loose stool, weakness, fever, cough, palpitation, etc. Modern pharmacological research shows that the honey-fried licorice root has the similar adrenocortical hormone-like effect and has the inhibition effect on hyperacidity caused by histamine; has effects in resisting acid and relieving spasm of smooth muscle of stomach and intestine; radix Glycyrrhizae Preparata has antiinflammatory and antiallergic effects, and can protect inflamed throat and trachea mucosa; the honey-fried licorice root contains roasted liquiritigenin, which is helpful for balancing the hormone content in the female body; the hypo-acid contained in radix Glycyrrhizae Preparata can block carcinogen from inducing tumor growth. The invention can harmonize the medicines to achieve mild medicine property.

13. Centipede: warm in nature, pungent and salty in flavor, toxic in flavor, entering liver, spleen and lung meridians, and has the effects of extinguishing wind, relieving spasm, counteracting toxic pathogen, dissipating nodulation, dredging collaterals and relieving pain.

The kidney tonifying and blood circulation activating are important methods for treating DPN, the DPN is mostly seen in the middle and later stages of disease development, and accords with the traditional Chinese medicine theory of chronic disease involving the kidney and chronic disease involving the stasis, although the clinical manifestations of DPN are complex and changeable, the affected parts of DPN are mostly dominated by the lower limbs, except common symptoms such as numbness, pain, muscular atrophy and the like, the DPN also has the kidney deficiency manifestations such as soreness and weakness of waist and knees, intolerance of cold and cold limbs, impotence in men, female hyposexuality and the like, and accords with the theory of the traditional Chinese medicine theory of kidney house of waist sufferers, below waist and knees, and kidney qi governs. DPN is mostly caused by long course of disease, or poor disease control, prolonged course of disease, gradual aggravation of kidney deficiency, insufficient functions of various organs, incapability of promoting blood circulation, slow blood flow, blood stasis in veins and pain caused by obstruction of collaterals; laboratory examination finds that the rheological property of the blood of a patient is abnormal, the blood is viscous, the deformability of red blood cells is reduced, the platelet aggregation is enhanced, the microcirculation perfusion is insufficient, and the like, namely invisible stasis.

Compared with the prior art, the invention has the beneficial effects that:

1. the invention provides a traditional Chinese medicine composition for treating diabetic peripheral neuropathy, which breaks through the traditional theory of deficiency of both qi and yin, considers that kidney deficiency and blood stasis are common pathological bases of diabetes and nerve complications thereof, and obviously improves the curative effect by optimizing the combination of the prescription and adding a kidney-tonifying and collateral-dredging medicine on the basis of the angelica sinensis Sini decoction in the Shanghai treatise on typhoid fever.

2. Under the guidance of the theory of traditional Chinese medicine, the invention combines with the modern pharmacological research result, and by optimizing the prescription combination, the kidney tonifying and meridian dredging medicine is added on the basis of the angelica Sini decoction, so that the curative effect is obviously improved, the blood running condition of a patient can be effectively improved, the recovery of nerve function is promoted, and the symptoms and physical signs of the patient are improved, and the invention is worthy of popularization and application.

3. The invention selects eucommia bark, parasitic loranthus, medicinal cyathula root, manchurian wildginger, cassia twig, astragalus root, Chinese angelica, red paeony root, dried rehmannia root, ephedra herb, earthworm and liquoric root to prepare a kidney tonifying and blood circulation promoting formula for treating DPN, wherein the eucommia bark, the parasitic loranthus and the medicinal cyathula root in the formula have the functions of nourishing liver and kidney and strengthening bones and muscles; ramulus Cinnamomi, herba asari, and herba Ephedrae have effects of warming channel, expelling cold, and dredging channels and collaterals; radix rehmanniae has the effects of nourishing yin and cooling blood and restricting dryness of cassia twig and asarum; astragalus root, Chinese angelica root, red peony root for supplementing qi and activating blood circulation; the liquorice is used for harmonizing the medicines and has the effects of tonifying qi, tonifying the kidney, removing blood stasis and dredging collaterals.

4. The traditional Chinese medicine composition has the effects of tonifying kidney, removing blood stasis and dredging collaterals, can effectively improve symptoms and signs of DPN treatment, is rich in raw materials, scientific and reasonable in formula, easy to prepare, convenient to take, good in effect and free of side effect, and is an innovation of DPN treatment medicines.

Detailed Description

In order to make the technical solutions of the present invention better understood and enable those skilled in the art to practice the present invention, the following embodiments are further described, but the present invention is not limited to the following embodiments.

The preparation method of the traditional Chinese medicine composition for treating diabetic peripheral neuropathy in the following examples is as follows: pulverizing the above materials, extracting with water, filtering, adding starch paste adjuvant into the filtrate, concentrating, drying to obtain granule, and packaging.

The preparation method of the traditional Chinese medicine composition for treating diabetic peripheral neuropathy of the following examples 1 to 3 is as follows: weighing raw material components of the traditional Chinese medicine composition, washing with water, drying, pulverizing, adding the powder into water, adding water, decocting for 3 times at 100 ℃, adding water 8 times of the weight of the raw material each time, decocting for 2 hours each time, mixing decoctions, filtering, discarding filter residue, taking filtrate, concentrating the filtrate to obtain an extract with a relative density of 1.25(70 ℃), drying under reduced pressure, and pulverizing into fine powder to obtain the traditional Chinese medicine extract.

Adding 250g of soluble starch and 250g of dextrin into 500g of the traditional Chinese medicine extract, mixing uniformly, granulating with 80% ethanol water solution, drying, granulating, preparing into 1000g of granules, and packaging, wherein each bag is 9 g.

Example 1

The embodiment of the invention relates to a traditional Chinese medicine composition for treating diabetic peripheral neuropathy, which is prepared from the following components in parts by weight: 15g of eucommia bark, 20g of Chinese taxillus twig, 20g of medicinal cyathula root, 6g of cassia twig, 3g of asarum, 20g of radix rehmanniae recen, 20g of astragalus root, 12g of angelica, 9g of red paeony root, 6g of mix-fried ephedra herb, 5g of earthworm, 6g of liquorice and 10g of centipede.

Example 2

The embodiment of the invention relates to a traditional Chinese medicine composition for treating diabetic peripheral neuropathy, which is prepared from the following components in parts by weight: 13g of eucommia bark, 18g of Chinese taxillus twig, 23g of medicinal cyathula root, 4g of cassia twig, 5g of asarum, 18g of radix rehmanniae recen, 18g of astragalus, 15g of angelica, 7g of red paeony root, 8g of mix-fried ephedra herb, 4g of earthworm, 5g of liquorice and 8g of centipede.

Example 3

The embodiment of the invention relates to a traditional Chinese medicine composition for treating diabetic peripheral neuropathy, which is prepared from the following components in parts by weight: 18g of eucommia bark, 23g of Chinese taxillus twig, 18g of medicinal cyathula root, 8g of cassia twig, 2g of asarum, 23g of radix rehmanniae recen, 23g of astragalus root, 10g of angelica, 12g of red paeony root, 4g of mix-fried ephedra herb, 6g of earthworm, 8g of liquorice and 12g of centipede.

The clinical effects of the above-mentioned Chinese medicinal compositions for treating diabetic neuropathy of examples 1 to 3 were similar, and thus, the clinical effects of the Chinese medicinal composition for treating diabetic peripheral neuropathy were observed and tested in example 1

1. Data and method

1.1 general data

110 cases of diabetic peripheral neuropathy patients treated in the endocrinology department in 2015 6-2018 and 12 are selected and are averagely divided into a control group (55 cases) and a treatment group (55 cases) according to the sequence of the treatment time of the patients. In the conventional group, 30 male patients and 25 female patients are aged 45-71 years, the average (59.36 +/-3.57) years, the course of disease is 5-10 years, and the average course of disease is (5.79 +/-1.26) years. 31 male patients and 24 female patients in the traditional Chinese medicine are aged 42-72 years, the average (59.58 +/-3.42) years, the course of disease is 1-14 years, and the average course of disease is (5.64 +/-1.33) years. The general data of the patients were compared and the differences between the groups were found to be statistically insignificant (P > 0.05).

1.2 inclusion and exclusion criteria

Patients are admitted to the system and are diagnosed according to relevant diagnosis standards proposed by WHO in 1999, and the patients know the information and agree to participate in the study, and have signed informed consent, patients with mental or intellectual abnormality, patients allergic to western medicines and Chinese medicines used in the invention, and patients with malignant tumor or cardiovascular and cerebrovascular diseases.

1.3 methods of treatment

The patients are treated by conventional blood sugar control treatment including diet control and exercise, and the conventional group is administered with mecobalamin (Wei material (China) pharmaceutical industry Co., Ltd., national Standard H20030812, specification: 0.5mg × 20s) orally 1 tablet at a time 3 times a day. The traditional Chinese medicine is treated by using the hebetor granules on the basis of conventional blood sugar control measures, the oral administration dosage is 9g per day, and the traditional Chinese medicine is taken warm in the morning, at noon and at night in 3 times. Treatment was continued for 1 month in all 2 groups.

1.4, observation index

Post-treatment hemorheological indices including Plasma Viscosity (PV), Hematocrit (HCT), whole blood high-shear viscosity (HBV), whole blood high-shear viscosity (LBV) were determined and compared for 2 groups of patients. The severity of peripheral neuropathy after treatment of the patients is compared, and the TCSS scoring system is adopted for scoring, wherein the TCSS scoring system comprises 3 dimensions of symptoms (6 points), feelings (5 points) and reflexes (8 points), the total score is 19 points, and the higher the score of the patients is, the more serious the disease condition is. The sensory nerve conduction velocity (MCV) and motor nerve conduction velocity (SCV) of the peroneal nerve and the tibial nerve of 2 groups of patients after treatment were measured using an electromyogram evoked potential apparatus and compared.

1.5 statistical methods

The data from this study were analyzed using SPSS 20.0 statistical software, and the counts and measures were expressed as rates (%) and means. + -. standard deviations ( X. + -.s), respectively, and as χ²And (5) checking and t-checking. If the test result is that P is less than 0.05, the difference is statistically significant.

2. Results

2.1, 2 groups of patients have lower indexes of PV, HCT, HBV and LBV than the indexes of conventional groups after treatment compared with the indexes of the hemorheology indexes of the traditional Chinese medicine group patients, and the difference has statistical significance (P is less than 0.05), which is shown in Table 1.

2.2 and 2 groups of patients have TCSS scores after treatment, and TCSS symptom scores, feeling scores and reflex scores after treatment of traditional Chinese medicine group patients are all obviously lower than those of the conventional group, and the differences have statistical significance (P is less than 0.05), which is shown in Table 2.

2.3 and 2 groups of patients suffered from the traditional Chinese medicine group after nerve conduction velocity comparison treatment, the MCV and SCV of the peroneal nerve and the tibial nerve of the patients are obviously larger than those of the conventional group, and the difference has statistical significance (P is less than 0.05), which is shown in Table 3.

The clinical curative effect of 2.4 and 2 groups of patients is obviously better than that of a control group in comparison with the overall curative effect of a treatment group, and the clinical curative effect is better. The total effective rate of the treatment group is obviously higher than that of the control group, and the effective rate and the effective number of the treatment group are both higher than those of the control group, which is shown in table 4.

Table 1 comparison of the hemorheological indices of patients in the control and treatment groups (example,

)

table 2 comparison of TCSS scores after treatment for the conventional and traditional chinese patients (example,

)

table 3 comparison of nerve conduction velocities in conventional and traditional chinese patients (example,)

TABLE 42 comparison of clinical efficacy in the patients

In conclusion, the invention selects eucommia bark, parasitic loranthus, medicinal cyathula root, asarum, cassia twig, astragalus, angelica, red peony root, radix rehmanniae, ephedra, earthworm and liquorice as the prescription for tonifying the kidney and activating blood circulation to treat DPN, and the eucommia bark, the parasitic loranthus and the medicinal cyathula root in the prescription have the functions of tonifying the liver and the kidney and strengthening the bones and muscles; ramulus Cinnamomi, herba asari, and herba Ephedrae have effects of warming channel, expelling cold, and dredging channels and collaterals; radix rehmanniae has the effects of nourishing yin and cooling blood and restricting dryness of cassia twig and asarum; astragalus root, Chinese angelica root, red peony root for supplementing qi and activating blood circulation; the liquorice is used for harmonizing the medicines and has the effects of tonifying qi, tonifying the kidney, removing blood stasis and dredging collaterals.

It should be noted that when the following claims refer to numerical ranges, it should be understood that both ends of each numerical range and any value between the two ends can be selected, and since the steps and methods used are the same as those in embodiments 1-3, the present invention describes preferred embodiments in order to prevent redundancy, but once the basic inventive concept is known, those skilled in the art can make other changes and modifications to these embodiments. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

Claims

1. The traditional Chinese medicine composition for treating diabetic peripheral neuropathy is characterized by comprising the following raw materials in parts by weight: 13-18 parts of eucommia bark, 18-23 parts of parasitic loranthus, 18-23 parts of medicinal cyathula root, 4-8 parts of cassia twig, 2-5 parts of asarum, 18-23 parts of radix rehmanniae recen, 18-23 parts of astragalus root, 10-15 parts of angelica, 7-12 parts of red peony root, 4-8 parts of mix-fried ephedra herb, 23-27 parts of earthworm, 5-8 parts of liquorice and 8-12 parts of centipede.

2. The traditional Chinese medicine composition for treating diabetic peripheral neuropathy is characterized by comprising the following raw materials in parts by weight: 15 parts of eucommia bark, 20 parts of parasitic loranthus, 20 parts of medicinal cyathula root, 6 parts of cassia twig, 3 parts of asarum, 20 parts of radix rehmanniae recen, 20 parts of astragalus, 12 parts of angelica, 9 parts of red paeony root, 6 parts of mix-fried ephedra herb, 25 parts of earthworm, 6 parts of liquorice and 10 parts of centipede.

3. The traditional Chinese medicine composition for treating diabetic peripheral neuropathy according to claim 1 or 2, wherein the pharmaceutical dosage form of the traditional Chinese medicine composition is granules.