CN106975050B - Chinese medicinal compound preparation for treating leukemia caused by consumptive disease and abdominal mass and preparation method thereof - Google Patents
Chinese medicinal compound preparation for treating leukemia caused by consumptive disease and abdominal mass and preparation method thereof Download PDFInfo
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Abstract
A Chinese medicinal compound preparation for treating leukemia caused by asthenia and abdominal mass, and its preparation method are provided. The preparation is prepared from the following medicinal raw materials in parts by weight: 18-48 parts of raw astragalus membranaceus, 6-15 parts of sweet wormwood herb, 6-15 parts of large-leaved gentian, 18-48 parts of roasted turtle shell, 18-48 parts of raw oyster, 9-24 parts of rhizoma sparganii, 9-24 parts of curcuma zedoary, 9-24 parts of sculellaria barbata, 9-24 parts of oldenlandia diffusa, 6-15 parts of edible tulip, 6-15 parts of folium cycas revolute, 18-48 parts of selfheal, 9-24 parts of ternate buttercup root and 4-10 parts of starwort. The preparation of the invention adopts a water boiling extraction method to extract the effective components in the raw material medicaments and keep the activity of the effective components, thus not only greatly improving the dissolution rate of the effective components in the medicaments, but also being beneficial to the absorption of the medicaments, thereby improving the bioavailability of the medicaments. In addition, the medicine is a pure Chinese herbal compound preparation, so that no toxic or side effect is generated after the medicine is taken by a patient for a long time, and the safety is good. In addition, the preparation method has simple process and convenient operation.
Description
Technical Field
The invention relates to a Chinese medicinal preparation and a preparation method thereof, in particular to a Chinese medicinal compound preparation which is prepared from Chinese medicaments serving as raw materials and is used for treating leukemia caused by consumptive disease and abdominal mass and a preparation method thereof.
Background
Leukemia is also called as leukemia, which is a malignant tumor of hematopoietic system caused by deficiency of vital qi and invasion of warm-heat toxin pathogen, which is caused by the mutual connection of heat toxin, blood stasis and phlegm turbidity, and the basic pathogenesis of blood injury of human body, and the main clinical manifestations of fever, hemorrhage, anemia and enlargement of liver, spleen and lymph nodes. Although the medicines clinically used for treating leukemia at present have a plurality of varieties, the pertinence is not strong, and the toxic and side effects of part of the medicines are large, so the effect of treating the leukemia caused by consumptive disease and abdominal mass after being taken is not obvious.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a traditional Chinese medicine compound preparation for treating leukemia caused by consumptive disease and abdominal mass and a preparation method thereof.
In order to achieve the purpose, the traditional Chinese medicine compound preparation for treating leukemia caused by consumptive disease and abdominal mass provided by the invention is prepared from the following raw materials in parts by weight:
radix astragali 18-48 sweet wormwood 6-15 large-leaf gentian root 6-15 roasted turtle shell 18-48 raw oyster 18-48 common burreed rhizome 9-24 zedoary 9-24 barbat skullcap 9-24 spreading hedyotis herb 9-24 edible tulip 6-15 iron leaf 6-15 common selfheal fruit-spike 18-48 ternate buttercup root 9-24 starwort root 4-10
The preparation method of the traditional Chinese medicine compound preparation for treating leukemia caused by consumptive disease and mass comprises the following steps of
(a) Weighing and mixing the roasted turtle shell and the raw oyster according to the proportion, and then adding water to decoct for 30 minutes once to prepare a decoction of the roasted turtle shell and the raw oyster;
(b) weighing and mixing the other medicinal raw materials except the roasted turtle shell and the raw oyster according to the proportion, then adding water for soaking for 25 minutes, then adding and mixing the roasted turtle shell, the raw oyster and decoction liquid thereof in the step (a), decocting for 30 minutes, and filtering to remove residues to prepare the traditional Chinese medicine compound preparation for treating the leukemia caused by consumptive disease and abdominal mass.
The Chinese medicinal compound preparation can be prepared into granules, tablets, capsules, syrups, oral liquids, pills and paste together with common pharmaceutic adjuvants.
The traditional Chinese medicine compound preparation for treating leukemia caused by consumptive disease and abdominal mass provided by the invention adopts a water boiling extraction method to extract the effective components in the raw material medicines and keeps the activity of the effective components, so that the dissolution rate of the effective components in the medicines is greatly improved, the absorption of the medicines is facilitated, and the bioavailability of the medicines is improved. In addition, the medicine is a pure Chinese herbal compound preparation, so that the medicine does not generate toxic or side effect after being taken by a patient for a long time, and has good safety. In addition, the preparation method of the invention has simple process and convenient operation.
Detailed Description
Leukemia has complex symptoms, prolonged course of disease and more complications. Clinically, deficiency syndrome, excess syndrome and syndrome of intermingled deficiency and excess are common. The method is based on nourishing yin essence, removing blood stasis and removing toxic substance. In the formula, raw astragalus membranaceus is sweet and slightly warm, has the effects of tonifying spleen and middle energizer, lifting yang and sinking, tonifying defensive qi and consolidating superficial resistance, promoting urination, expelling toxin and promoting granulation, and is a key medicine for tonifying middle-jiao and Qi, and is a monarch medicine. Sweet wormwood herb, herba artemisiae annuae, with pungent, bitter and cold properties, clears deficiency heat, cools blood and removes steaming; carapax Trionycis preparata with sweet and salty taste and cold property, has effects of nourishing yin, suppressing yang, relieving fever, removing dampness, softening hardness and resolving hard mass; the rhizoma sparganii is pungent and bitter, can break blood and promote qi circulation, and can remove food retention and relieve pain; the barbed skullcap herb is pungent and cool, and has the effects of clearing away heat and toxic materials, promoting urination, reducing swelling, relieving pain and resisting cancer; the edible tulip is sweet, slightly pungent and cool, and has the effects of clearing away heat and toxic materials, eliminating carbuncles and dissipating stagnation; the selfheal is pungent, bitter and cold, has the effects of clearing heat and purging fire, improving eyesight, eliminating stagnation and reducing swelling, and the medicines for clearing deficiency heat, cooling blood and detoxifying, inducing diuresis and reducing swelling are used as ministerial medicines together. Large-leaved gentian is pungent and bitter in flavor and mild in nature, and has the effects of expelling wind-damp, dredging collaterals and relieving pain, and clearing away deficiency heat and damp-heat; raw oysters are salty and slightly cold, subdue yang and tonify yin, soften hardness and dissipate stagnation; the zedoary is pungent, bitter and warm, breaks blood and promotes qi circulation, and removes food retention and relieves pain; the oldenlandia diffusa is slightly bitter, sweet and cold, clears away heat and toxic materials, and promotes diuresis for treating stranguria; folium fici, sweet and sour, has effects of removing blood stasis, relieving swelling, regulating stomach function and resolving hard mass; the radix ranunculi ternati is sweet and pungent and is slightly warm, can reduce phlegm and eliminate stagnation, and can remove toxicity and reduce swelling, and the traditional Chinese medicines can be used as adjuvant medicines for dispelling wind and dredging collaterals, promoting diuresis and excreting dampness, clearing deficiency heat, and removing toxicity, reducing phlegm and reducing swelling. Bupleurum root, radix Stellariae, with sweet and slightly cold properties, clears deficiency heat, removes malnutritional fever, and introduces herbs into the channels as guiding drugs. The recipe has the effects of nourishing yin, clearing heat, removing toxicity, relieving swelling, relieving pain and resisting cancer, so the recipe is suitable for the leukemia caused by consumptive disease and abdominal mass.
The following will explain the compound Chinese medicine preparation for treating leukemia and its preparation method in detail by combining the examples.
Example 1:
the compound traditional Chinese medicine preparation for treating leukemia caused by consumptive disease and abdominal mass provided by the embodiment is prepared from the following raw materials in parts by weight:
the preparation method of the traditional Chinese medicine compound preparation for treating leukemia caused by consumptive disease and mass comprises the following steps of
(a) Weighing and mixing the roasted turtle shell and the raw oyster according to the proportion, and then adding water to decoct for 30 minutes once to prepare a decoction of the roasted turtle shell and the raw oyster;
(b) weighing and mixing the other medicinal raw materials except the roasted turtle shell and the raw oyster according to the proportion, then adding water for soaking for 25 minutes, then adding and mixing the roasted turtle shell, the raw oyster and decoction liquid thereof in the step (a), decocting for 30 minutes, and filtering to remove residues to prepare the traditional Chinese medicine compound preparation for treating the leukemia caused by consumptive disease and abdominal mass.
The Chinese medicinal compound preparation can be prepared into granules, tablets, capsules, syrups, oral liquids, pills and paste together with common pharmaceutic adjuvants.
Example 2:
the compound traditional Chinese medicine preparation for treating leukemia caused by consumptive disease and abdominal mass provided by the embodiment is prepared from the following raw materials in parts by weight:
the preparation method is the same as example 1.
Example 3:
the compound traditional Chinese medicine preparation for treating leukemia caused by consumptive disease and abdominal mass provided by the embodiment is prepared from the following raw materials in parts by weight:
the preparation method is the same as example 1.
The traditional Chinese medicine compound preparation for treating leukemia caused by consumptive disease and abdominal mass provided by the invention is brown to tan; light smell, slightly bitter taste. In order to verify the treatment effect of the traditional Chinese medicine compound preparation, the inventor carries out systematic clinical observation on 301 patients with consumptive disease and abdominal mass type leukemia by using the traditional Chinese medicine compound preparation, wherein 80 patients with 21-30 years old, 115 patients with 31-40 years old and 106 patients with 41-50 years old take 150ml of the traditional Chinese medicine compound preparation every time, 3 times are taken every day, and 1 treatment course is 120 days. After 1 treatment course, 7 cases of the traditional Chinese medicine are cured (blood is normally checked by routine examination, bone marrow is normally checked, chromosome is normally checked, and main symptoms are obviously improved) and account for 2.3 percent; 133 effective (each test is obviously improved, and the main symptoms are improved) cases account for 44.2 percent; 161 cases of ineffectiveness (no change in each test examination, no improvement in chief symptoms) accounted for 53.5%; the total effective rate is 46.5%. 13 cases are cured after 2 courses of treatment, accounting for 4.3 percent; 211 effective cases account for 70.1%; 77 cases with no effect account for 25.6%; the total effective rate is 74.4%.
Meanwhile, the inventor analyzes the relationship between the treatment effect and the age and the relationship between the treatment effect and the treatment course, and the analysis results are respectively shown in tables 1 and 2.
Table 1: the relation table between the treatment effect and the age of the traditional Chinese medicine compound preparation provided by the invention
The data in Table 1 above are expressed as x2The test method calculates that the result is 0.050 > P > 0.025, thereby proving that the treatment effect of the traditional Chinese medicine compound preparation for treating consumptive disease and abdominal mass type leukemia provided by the invention on all age groups does not change with age.
Table 2: the relation table of the treatment effect and the treatment course of the traditional Chinese medicine compound preparation provided by the invention
The data in Table 2 above are expressed as x2The result of calculation by the inspection method is that P is less than 0.005, so that the treatment of consumptive disease and abdominal mass type leukemia by taking the traditional Chinese medicine compound preparation provided by the invention can be proved, and the cure rate and the effective rate are obviously improved along with the deep treatment.
Claims (3)
1. A traditional Chinese medicine compound preparation for treating leukemia caused by consumptive disease and abdominal mass is characterized in that: the traditional Chinese medicine compound preparation for treating leukemia caused by consumptive disease and abdominal mass is prepared from the following raw materials in parts by weight:
18-48 of raw astragalus root, 6-15 of sweet wormwood, 6-15 of large-leaf gentian root, 18-48 of roasted turtle shell, 18-48 of raw oyster
9-24 zedoary of rhizoma sparganii, 9-24 barbed skullcap herb, 9-24 spreading hedyotis herb, 9-24 Indian iphigenia bulb, 6-15
6-15 parts of folium cycas, 18-48 parts of selfheal, 9-24 parts of ternate buttercup root and 4-10 parts of starwort root.
2. A method for preparing the compound traditional Chinese medicine preparation for treating leukemia caused by consumptive disease and abdominal mass as claimed in claim 1, which is characterized in that: the preparation method comprises the following steps of
(a) Weighing and mixing the roasted turtle shell and the raw oyster according to the proportion, and then adding water to decoct for 30 minutes once to prepare a decoction of the roasted turtle shell and the raw oyster;
(b) weighing and mixing the other medicinal raw materials except the roasted turtle shell and the raw oyster according to the proportion, then adding water for soaking for 25 minutes, then adding and mixing the roasted turtle shell, the raw oyster and decoction liquid thereof in the step (a), decocting for 30 minutes, and filtering to remove residues to prepare the traditional Chinese medicine compound preparation for treating the leukemia caused by consumptive disease and abdominal mass.
3. The method of claim 2, wherein: the Chinese medicinal compound preparation and common pharmaceutical excipients are prepared into granules, tablets, capsules, syrups, oral liquid, pills or paste.
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