CN107029111B - Traditional Chinese medicine compound preparation for treating leukemia caused by vital qi deficiency and pathogenic factor latent and preparation method thereof - Google Patents

Abstract

A Chinese medicinal compound preparation for treating leukemia caused by deficiency of vital qi and pathogenic factors and its preparation method are provided. The preparation is prepared from the following medicinal raw materials in parts by weight: 6-15 parts of radix pseudostellariae, 9-24 parts of fried bighead atractylodes rhizome, 9-24 parts of poria cocos, 6-15 parts of lucid ganoderma, 6-15 parts of rhizoma polygonati, 9-24 parts of fried white peony root, 6-15 parts of pseudo-ginseng, 9-24 parts of barbed skullcap herb, 9-24 parts of oldenlandia diffusa, 6-15 parts of Indian iphigenia bulb, 6-15 parts of selaginella tamariscina, 9-24 parts of ternate buttercup root, 9-24 parts of greater celandine herb, 6-15 parts of platycodon grandiflorum, 6-. The preparation of the invention adopts a water boiling extraction method to extract the effective components in the raw material medicaments and keep the activity of the effective components, thus not only greatly improving the dissolution rate of the effective components in the medicaments, but also being beneficial to the absorption of the medicaments, thereby improving the bioavailability of the medicaments. In addition, the medicine is a pure Chinese herbal compound preparation, so that the medicine does not generate toxic or side effect after being taken by a patient for a long time, and has good safety. In addition, the preparation method of the invention has simple process and convenient operation.

Description

Traditional Chinese medicine compound preparation for treating leukemia caused by vital qi deficiency and pathogenic factor latent and preparation method thereof

Technical Field

The invention relates to a Chinese medicinal preparation and a preparation method thereof, in particular to a Chinese medicinal compound preparation which is prepared from Chinese medicaments serving as raw materials and is used for treating leukemia caused by vital qi deficiency and pathogenic factor latent and a preparation method thereof.

Background

Leukemia is also called as leukemia, which is a malignant tumor of hematopoietic system caused by deficiency of vital qi and invasion of warm-heat toxin pathogen, which is caused by the mutual connection of heat toxin, blood stasis and phlegm turbidity, and the basic pathogenesis of blood injury of human body, and the main clinical manifestations of fever, hemorrhage, anemia and enlargement of liver, spleen and lymph nodes. Although the medicines clinically used for treating leukemia at present have a plurality of varieties, the pertinence is not strong, and part of the medicines have large toxic and side effects, so the effect of treating the leukemia caused by the deficiency of vital qi and pathogenic factors is not obvious after the medicines are taken.

Disclosure of Invention

In order to solve the problems, the invention aims to provide a traditional Chinese medicine compound preparation for treating leukemia caused by vital qi deficiency and pathogenic factor latent and a preparation method thereof.

In order to achieve the aim, the traditional Chinese medicine compound preparation for treating the leukemia caused by vital qi deficiency and pathogenic factor prostration provided by the invention is prepared from the following raw materials in parts by weight:

6-15 parts of radix pseudostellariae, 9-24 parts of fried bighead atractylodes rhizome, 9-24 parts of poria cocos, 9-24 parts of lucid ganoderma, 6-15 parts of rhizoma polygonati

Stir-fried white peony root 9-24 notoginseng 6-15 barbed skullcap herb 9-24 oldenlandia 9-24

Pseudobulbus Cremastrae Seu pleiones 6-15 herba Selaginellae Doederleinii 6-15 radix Ranunculi Ternati 9-24 herba Chelidonii 9-24 radix Platycodi 6-15

6-15 parts of charred schizonepeta and 4-10 parts of divaricate saposhnikovia root

The preparation method of the traditional Chinese medicine compound preparation for treating the leukemia caused by vital qi deficiency and pathogenic factor latent is carried out according to the following steps in sequence

(a) Weighing and mixing the other medicinal raw materials except the pseudo-ginseng according to the proportion, then adding water to soak for 25 minutes, then decocting for 30 minutes, and filtering to remove residues to prepare liquid medicine;

(b) pulverizing Notoginseng radix into fine powder, and taking together with the above medicinal liquid as the compound Chinese medicinal preparation.

The Chinese medicinal compound preparation can be prepared into granules, tablets, capsules, syrups, oral liquids, pills and paste together with common pharmaceutic adjuvants.

The traditional Chinese medicine compound preparation for treating the leukemia caused by vital qi deficiency and pathogenic factor prostration provided by the invention adopts a water boiling extraction method to extract the effective components in the raw material medicines and keep the activity of the effective components, so that the dissolution rate of the effective components in the medicines is greatly improved, the absorption of the medicines is facilitated, and the bioavailability of the medicines is improved. In addition, the medicine is a pure Chinese herbal compound preparation, so that the medicine does not generate toxic or side effect after being taken by a patient for a long time, and has good safety. In addition, the preparation method of the invention has simple process and convenient operation.

Detailed Description

Leukemia has complex symptoms, prolonged course of disease and more complications. Clinically, deficiency syndrome, excess syndrome and syndrome of intermingled deficiency and excess are common. The method is used for strengthening body resistance and removing toxic substances. In the formula, radix pseudostellariae is sweet and slightly bitter, has the effects of tonifying qi and spleen, promoting the production of body fluid and moistening lung, and is a monarch drug. The fried rhizoma atractylodis macrocephalae is sweet, bitter and warm, has the effects of tonifying qi and strengthening spleen, eliminating dampness and promoting urination, and is the first important medicine for tonifying qi and strengthening spleen; glossy ganoderma is sweet and neutral, and has the effects of tonifying qi and soothing nerves; parched radix Paeoniae alba is slightly cold in bitter acid, and has effects of nourishing blood, astringing yin, softening liver, relieving pain, and suppressing liver yang; the barbed skullcap herb is pungent and cool, and has the effects of clearing away heat and toxic materials, promoting urination, reducing swelling, relieving pain and resisting cancer; the edible tulip is sweet, slightly pungent and cool, and has the effects of clearing away heat and toxic materials, eliminating carbuncles and dissipating stagnation; radix Ranunculi Ternati is sweet and pungent, and has mild temperature, and has effects of eliminating phlegm and resolving masses, removing toxic substance and relieving swelling; the platycodon root is bitter and pungent, can eliminate phlegm and discharge pus, has the effects of benefiting qi and nourishing blood, clearing heat and removing toxicity, eliminating phlegm and resolving masses and is used as a ministerial drug together. Poria is sweet and mild, and has effects of promoting diuresis, eliminating dampness, invigorating spleen, eliminating phlegm, calming heart, and tranquilizing mind; rhizoma Polygonati is sweet and neutral, and has effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney; notoginseng radix is sweet, slightly bitter and warm, and has effects of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain; the oldenlandia diffusa is slightly bitter, sweet and cold, clears away heat and toxic materials, and promotes diuresis for treating stranguria; the selaginella doederleinii hieron is sweet, slightly bitter and cool, and has the effects of clearing away heat and toxic materials, resisting cancer and stopping bleeding; the celandine is bitter and cold, and has the effects of clearing heat, removing toxicity and relieving pain; the schizonepeta herb is pungent and warm in flavor and mild in property, has the effects of dispelling wind and relieving exterior syndrome, promoting eruption and eliminating sore, and stopping bleeding, is an adjuvant drug for clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, and inducing diuresis to alleviate edema. Ledebouriella root, radix Saposhnikoviae, pungent, sweet and slightly warm in property, dispels wind and relieves exterior syndrome, excels in dampness and relieves pain, and relieves spasm, and is used as a guiding drug. The formula has the effects of tonifying qi and nourishing blood, promoting qi and activating blood circulation, inducing diuresis and excreting dampness, and has the effects of relieving swelling, alleviating pain and resisting cancer, so the formula is suitable for the leukemia caused by vital qi deficiency and pathogenic factor prostration.

The following will explain the compound Chinese medicine preparation for treating leukemia and its preparation method in detail by combining the examples.

Example 1:

the compound traditional Chinese medicine preparation for treating leukemia caused by vital qi deficiency and pathogenic factor prostration provided by the embodiment is prepared from the following raw materials in parts by weight:

the preparation method of the traditional Chinese medicine compound preparation for treating the leukemia caused by vital qi deficiency and pathogenic factor latent is carried out according to the following steps in sequence

(a) Weighing and mixing the other medicinal raw materials except the pseudo-ginseng according to the proportion, then adding water to soak for 25 minutes, then decocting for 30 minutes, and filtering to remove residues to prepare liquid medicine;

(b) pulverizing Notoginseng radix into fine powder, and taking together with the above medicinal liquid as the compound Chinese medicinal preparation.

In addition, the traditional Chinese medicine compound preparation can be prepared into granules, tablets, capsules, syrups, oral liquids, pills and paste together with common pharmaceutical excipients.

Example 2:

the compound traditional Chinese medicine preparation for treating leukemia caused by vital qi deficiency and pathogenic factor prostration provided by the embodiment is prepared from the following raw materials in parts by weight:

the preparation method is the same as example 1.

Example 3:

the compound traditional Chinese medicine preparation for treating leukemia caused by vital qi deficiency and pathogenic factor prostration provided by the embodiment is prepared from the following raw materials in parts by weight:

the preparation method is the same as example 1.

The traditional Chinese medicine compound preparation for treating the leukemia caused by vital qi deficiency and pathogenic factor prostration provided by the invention is brown to tan; light smell, slightly bitter taste. In order to verify the treatment effect of the traditional Chinese medicine compound preparation, the inventor carries out systematic clinical observation on 306 patients with vital-qi deficiency and pathogenic-pathogen latent leukemia by using the traditional Chinese medicine compound preparation, wherein 82 patients with 21-30 years old, 116 patients with 31-40 years old and 108 patients with 41-50 years old take 150ml of the traditional Chinese medicine compound preparation every time, 3 times are taken every day, and 1 treatment course is 120 days. After 1 treatment course, 7 cases of the traditional Chinese medicine are cured (blood is normally checked by routine examination, bone marrow is normally checked, chromosome is normally checked, and main symptoms are obviously improved) and account for 2.3 percent; 144 effective cases (obviously improving each test examination and improving main symptoms) account for 47.1 percent; 155 cases of ineffectiveness (no change in each test examination, no improvement in chief symptoms) account for 50.7%; the total effective rate is 49.3%. 13 cases are cured after 2 courses of treatment, accounting for 4.2 percent; 222 effective cases account for 72.5%; 71 cases of ineffectiveness, accounting for 23.2%; the total effective rate is 76.8%.

Meanwhile, the inventor analyzes the relationship between the treatment effect and the age and the relationship between the treatment effect and the treatment course, and the analysis results are respectively shown in tables 1 and 2.

Table 1: the relation table between the treatment effect and the age of the traditional Chinese medicine compound preparation provided by the invention

The data in Table 1 above are expressed as x²The test method calculates that the result is 0.050 > P > 0.025, so that the traditional Chinese medicine compound preparation provided by the invention can be proved to be taken to treat the leukemia with vital qi deficiency and pathogenic factor deficiency, and the treatment effect on all age groups is not changed along with the age.

Table 2: the relation table of the treatment effect and the treatment course of the traditional Chinese medicine compound preparation provided by the invention

The data in Table 2 above are expressed as x²The test method calculates that the result is that P is less than 0.005, so that the curative rate and the effective rate are obviously improved along with the deep treatment when the traditional Chinese medicine compound preparation provided by the invention is taken to treat the leukemia with vital qi deficiency and pathogenic factor deficiency.

Claims (3)

1. A traditional Chinese medicine compound preparation for treating leukemia caused by vital qi deficiency and pathogenic factor prostration is characterized in that: the traditional Chinese medicine compound preparation for treating the leukemia caused by vital qi deficiency and pathogenic factor latent is prepared from the following raw materials in parts by weight:

6-15 parts of radix pseudostellariae, 9-24 parts of fried bighead atractylodes rhizome, 9-24 parts of poria cocos, 9-24 parts of lucid ganoderma, 6-15 parts of rhizoma polygonati

Stir-fried white peony root 9-24 notoginseng 6-15 barbed skullcap herb 9-24 spreading hedyotis herb 9-24

Pseudobulbus Cremastrae Seu pleiones 6-15 herba Selaginellae Doederleinii 6-15 radix Ranunculi Ternati 9-24 herba Chelidonii 9-24 radix Platycodi 6-15

6-15 parts of charred schizonepeta and 4-10 parts of divaricate saposhnikovia root.

2. A method for preparing the compound traditional Chinese medicine preparation for treating leukemia caused by vital qi deficiency and pathogenic factor of the body as claimed in claim 1, which is characterized in that: the preparation method comprises the following steps of

(a) Weighing and mixing the other medicinal raw materials except the pseudo-ginseng according to the proportion, then adding water to soak for 25 minutes, then decocting for 30 minutes, and filtering to remove residues to prepare liquid medicine;

(b) pulverizing Notoginseng radix into fine powder, and taking together with the above medicinal liquid as the compound Chinese medicinal preparation.

3. The method of claim 2, wherein: the Chinese medicinal compound preparation and common pharmaceutical excipients are prepared into granules, tablets, capsules, syrups, oral liquid, pills or paste.