CN107029116B - Traditional Chinese medicine compound preparation for treating leukemia caused by spleen deficiency and stomach heat and preparation method - Google Patents
Traditional Chinese medicine compound preparation for treating leukemia caused by spleen deficiency and stomach heat and preparation method Download PDFInfo
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Abstract
A Chinese medicinal compound preparation for treating leukemia caused by spleen deficiency and stomach heat and its preparation method are provided. The preparation is prepared from the following medicinal raw materials in parts by weight: 6-15 parts of lucid ganoderma, 9-24 parts of fried bighead atractylodes rhizome, 9-24 parts of poria cocos, 6-15 parts of dendrobium, 6-15 parts of scorched gardenia, 9-24 parts of calcined concha arcae, 6-15 parts of thunberg fritillary bulb, 9-24 parts of barbed skullcap herb, 9-24 parts of spreading hedyotis herb, 6-15 parts of Indian iphigenia bulb, 9-24 parts of black nightshade herb and 4-10 parts of raw liquorice. The preparation of the invention adopts a water boiling extraction method to extract the effective components in the raw material medicaments and keep the activity of the effective components, thus not only greatly improving the dissolution rate of the effective components in the medicaments, but also being beneficial to the absorption of the medicaments, thereby improving the bioavailability of the medicaments. In addition, the medicine is a pure Chinese herbal compound preparation, so that no toxic or side effect is generated after the medicine is taken by a patient for a long time, and the safety is good. In addition, the preparation method of the invention has simple process and convenient operation.
Description
Technical Field
The invention relates to a Chinese medicinal preparation and a preparation method thereof, in particular to a Chinese medicinal compound preparation which is prepared from Chinese medicaments serving as raw materials and is used for treating leukemia caused by spleen deficiency and stomach heat and a preparation method thereof.
Background
Leukemia is also called as leukemia, which is a malignant tumor of hematopoietic system caused by deficiency of vital qi and invasion of warm-heat toxin pathogen, which is caused by the mutual connection of heat toxin, blood stasis and phlegm turbidity, and the basic pathogenesis of blood injury of human body, and the main clinical manifestations of fever, hemorrhage, anemia and enlargement of liver, spleen and lymph nodes. Although the medicines clinically used for treating leukemia at present have a plurality of varieties, the pertinence is not strong, and the toxic and side effects of part of the medicines are large, so the effect of treating the leukemia caused by spleen deficiency and stomach heat after taking is not obvious.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a traditional Chinese medicine compound preparation for treating leukemia caused by spleen deficiency and stomach heat and a preparation method thereof.
In order to achieve the purpose, the traditional Chinese medicine compound preparation for treating leukemia caused by spleen deficiency and stomach heat provided by the invention is prepared from the following raw materials in parts by weight:
6-15 parts of ganoderma lucidum, 9-24 parts of roasted rhizoma atractylodis macrocephalae, 9-24 parts of poria cocos, 9-24 parts of dendrobium nobile, 6-15 parts of scorched gardenia jasminoides, 6-15 parts of fructus gardeniae
9-24 of calcined concha arcae, 6-15 of thunberg fritillary bulb, 9-24 of barbed skullcap herb, 9-24 of spreading hedyotis herb
Edible tulip 6-15 black nightshade 9-24 raw licorice root 4-10
The preparation method of the traditional Chinese medicine compound preparation for treating the leukemia caused by spleen deficiency and stomach heat is carried out according to the following steps in sequence
(a) Weighing calcined concha arcae according to the proportion, and adding water for decocting for 30 minutes;
(b) weighing and mixing the raw materials except the calcined concha arcae in proportion, then adding water to soak for 25 minutes, then adding and mixing the calcined concha arcae in the step (a) and decoction thereof, decocting for 30 minutes, and filtering to remove residues to prepare the traditional Chinese medicine compound preparation for treating the leukemia caused by spleen deficiency and stomach heat.
The Chinese medicinal compound preparation can be prepared into granules, tablets, capsules, syrups, oral liquids, pills and paste together with common pharmaceutic adjuvants.
The traditional Chinese medicine compound preparation for treating the leukemia caused by spleen deficiency and stomach heat provided by the invention adopts a water boiling extraction method to extract the effective components in the raw material medicines and keep the activity of the effective components, so that the dissolution rate of the effective components in the medicines is greatly improved, the absorption of the medicines is facilitated, and the bioavailability of the medicines is improved. In addition, the medicine is a pure Chinese herbal compound preparation, so that the medicine does not generate toxic or side effect after being taken by a patient for a long time, and has good safety. In addition, the preparation method of the invention has simple process and convenient operation.
Detailed Description
Leukemia has complex symptoms, prolonged course of disease and more complications. Clinically, deficiency syndrome, excess syndrome and syndrome of intermingled deficiency and excess are common. The method is based on the principle of replenishing qi, invigorating spleen, and clearing away stomach fire. Ganoderma lucidum is sweet and neutral in nature, and is used as a monarch drug for invigorating qi and tranquilizing mind. The fried rhizoma atractylodis macrocephalae is sweet, bitter and warm, has the effects of tonifying qi and strengthening spleen, eliminating dampness and promoting urination, and is the first important medicine for tonifying qi and strengthening spleen; the dendrobium nobile is sweet and slightly cold, can tonify stomach and promote fluid production, nourish yin and clear heat; calcined concha arcae is salty and flat, and has the effects of eliminating phlegm, softening hardness, removing blood stasis, resolving masses, relieving hyperacidity and relieving pain; the barbed skullcap herb is pungent and cool, and has the effects of clearing away heat and toxic materials, promoting urination, reducing swelling, relieving pain and resisting cancer; the edible tulip is sweet, slightly pungent and cool, and has the effects of clearing away heat and toxic materials, eliminating carbuncles and dissipating stagnation; the medicines have the effects of tonifying qi and strengthening spleen, inducing diuresis and drying dampness, and reducing swelling and dissipating stagnation, and are used as ministerial medicines. Poria is sweet and mild, and has effects of promoting diuresis, eliminating dampness, invigorating spleen, eliminating phlegm, calming heart, and tranquilizing mind; the charred gardenia is bitter and cold, has the effects of purging fire and relieving restlessness, clearing heat and promoting diuresis, cooling blood and removing toxicity and stopping bleeding; zhejiang fritillaria is bitter and cold, clears heat and reduces phlegm, and eliminates stagnation and abscess; the oldenlandia diffusa is slightly bitter, sweet and cold, clears away heat and toxic materials, and promotes diuresis for treating stranguria; the black nightshade herb is bitter and cold in property, has the effects of clearing heat and removing toxicity, and activating blood and relieving swelling, and the medicaments have the effects of inducing diuresis and tonifying spleen, clearing heat and removing toxicity, and cooling blood and relieving swelling, and are used as adjuvant medicaments together. Raw licorice root, radix Glycyrrhizae Praeparata, is sweet and neutral in nature, and has the effects of invigorating the spleen, replenishing qi, clearing away heat and toxic material, relieving pain, and harmonizing the effects of the other drugs in the recipe. The formula has the effects of tonifying qi, activating blood circulation, clearing away heat and toxic materials, inducing diuresis, invigorating spleen, reducing swelling and resisting cancer, and is suitable for leukemia caused by spleen deficiency and stomach heat.
The following will explain the compound Chinese medicine preparation for treating leukemia and its preparation method in detail by combining the examples.
Example 1:
the compound traditional Chinese medicine preparation for treating leukemia caused by spleen deficiency and stomach heat is prepared from the following raw materials in parts by weight:
the preparation method of the traditional Chinese medicine compound preparation for treating the leukemia caused by spleen deficiency and stomach heat is carried out according to the following steps in sequence
(a) Weighing calcined concha arcae according to the proportion, and adding water for decocting for 30 minutes;
(b) weighing and mixing the raw materials except the calcined concha arcae in proportion, then adding water to soak for 25 minutes, then adding and mixing the calcined concha arcae in the step (a) and decoction thereof, decocting for 30 minutes, and filtering to remove residues to prepare the traditional Chinese medicine compound preparation for treating the leukemia caused by spleen deficiency and stomach heat.
In addition, the traditional Chinese medicine compound preparation can be prepared into granules, tablets, capsules, syrups, oral liquids, pills and paste together with common pharmaceutical excipients.
Example 2:
the compound traditional Chinese medicine preparation for treating leukemia caused by spleen deficiency and stomach heat is prepared from the following raw materials in parts by weight:
the preparation method is the same as example 1.
Example 3:
the compound traditional Chinese medicine preparation for treating leukemia caused by spleen deficiency and stomach heat is prepared from the following raw materials in parts by weight:
the preparation method is the same as example 1.
The traditional Chinese medicine compound preparation for treating leukemia caused by spleen deficiency and stomach heat provided by the invention is brown to tan; light smell, slightly bitter taste. In order to verify the treatment effect of the traditional Chinese medicine compound preparation, the inventor carries out systematic clinical observation on 320 patients suffering from spleen deficiency and stomach heat type leukemia by using the traditional Chinese medicine compound preparation, wherein 91 patients of 21-30 years old, 116 patients of 31-40 years old and 113 patients of 41-50 years old take 150ml of the traditional Chinese medicine compound preparation every time, 3 times are taken every day, and 1 treatment course is 120 days. After 1 treatment course, 7 cases of the traditional Chinese medicine are cured (blood is normally checked by routine examination, bone marrow is normally checked, chromosome is normally checked, and main symptoms are obviously improved) and account for 2.2 percent; 140 effective (obviously improving each test examination and improving the main symptoms) cases account for 43.8 percent; 173 cases of no effect (no change in each test, no improvement in chief symptoms) account for 54.1%; the total effective rate is 45.9%. After 2 treatment courses, 12 cases are cured, accounting for 3.8 percent; 215 effective cases account for 67.2%; 93 cases with no effect, accounting for 29.0%; the total effective rate is 71.0%.
Meanwhile, the inventor analyzes the relationship between the treatment effect and the age and the relationship between the treatment effect and the treatment course, and the analysis results are respectively shown in tables 1 and 2.
Table 1: the relation table between the treatment effect and the age of the traditional Chinese medicine compound preparation provided by the invention
The data in Table 1 above are expressed as x2The test method carries out calculation, and the result is 0.050 > P > 0.025, so that the traditional Chinese medicine compound preparation provided by the invention can be proved to be taken to treat spleen deficiency and stomach heat type leukemia, and the treatment effect on all age groups is not changed along with the age.
Table 2: the relation table of the treatment effect and the treatment course of the traditional Chinese medicine compound preparation provided by the invention
The data in Table 2 above are expressed as x2The test method calculates that the result is that P is less than 0.005, so that the traditional Chinese medicine compound preparation provided by the invention is proved to be taken to treat spleen deficiency and stomach heat type leukemia, and the cure rate and the effective rate are obviously improved along with the deep treatment.
Claims (3)
1. A traditional Chinese medicine compound preparation for treating leukemia caused by spleen deficiency and stomach heat is characterized in that: the traditional Chinese medicine compound preparation is prepared from the following raw materials in parts by weight:
6-15 parts of ganoderma lucidum, 9-24 parts of roasted rhizoma atractylodis macrocephalae, 9-24 parts of poria cocos, 9-24 parts of dendrobium nobile, 6-15 parts of scorched gardenia jasminoides, 6-15 parts of fructus gardeniae
9-24 of calcined concha arcae, 6-15 of thunberg fritillary bulb, 9-24 of barbed skullcap herb, 9-24 of spreading hedyotis herb
6-15 of edible tulip, 9-24 of black nightshade and 4-10 of raw liquorice.
2. A method for preparing the compound traditional Chinese medicine preparation for treating leukemia caused by spleen deficiency and stomach heat according to claim 1, which is characterized in that: the preparation method comprises the following steps:
(a) weighing calcined concha arcae according to the proportion, and adding water for decocting for 30 minutes;
(b) weighing and mixing the raw materials except the calcined concha arcae in proportion, then adding water to soak for 25 minutes, then adding and mixing the calcined concha arcae in the step (a) and decoction thereof, decocting for 30 minutes, and filtering to remove residues to prepare the traditional Chinese medicine compound preparation for treating the leukemia caused by spleen deficiency and stomach heat.
3. The method of claim 2, wherein: the Chinese medicinal compound preparation and common pharmaceutical excipients are prepared into granules, tablets, capsules, syrups, oral liquid, pills or paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710207604.7A CN107029116B (en) | 2017-03-31 | 2017-03-31 | Traditional Chinese medicine compound preparation for treating leukemia caused by spleen deficiency and stomach heat and preparation method |
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