CN103893383A - Traditional Chinese medicine composition for treating chronic fatigue syndrome and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chronic fatigue syndrome and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating chronic fatigue syndrome and a preparation method thereof. The traditional Chinese medicine composition comprises the following crude medicaments in parts by weight: 100-300 parts of ginseng, 200-400 parts of medlar, 100-200 parts of rhodiola rosea, and 200-400 parts of semen trigonellae. The traditional Chinese medicine composition has an excellent curative effect on a sufferer with the chronic fatigue syndrome, especially, a male patient. The traditional Chinese medicine composition is good in mouthfeel, quick to absorb, scientific and reasonable in formula, and simple and feasible in preparation method.
Description
Technical field
The present invention relates to a kind of compositions for the treatment of chronic fatigue syndrome, belong to the field of Chinese medicines.
Background technology
Chronic fatigue syndrome (Chronic Fatigue Syndrome), claim again chronic class Monocyte increase disease, complicated symptoms, mainly comprise lymphadenectasis, extremely tired, lose that appetite, upper respiratory tract infection are shown effect repeatedly, memory is low, muscle and arthralgia etc., therefore on diagnosing, be easy to obscure mutually with flu, depression.The underactivity being caused by chronic fatigue syndrome, immune system to human body, blood circulation, digestive system, nervous system, reproductive system etc. bring obvious side effect, have greatly increased ill probability.In addition, due to the reason such as traditional view, the division of labor in society, huge pressure is all being born in body & mind two aspects of being everlasting when male; Under the impact of the unfavorable factors such as social rhythm's quickening, mental pressure increasing, environmental pollution, male suffers from chronic fatigue syndrome and is just presenting the trend rising year by year simultaneously.By chronic fatigue syndrome cause that a large amount of male's energy is long-term not enough, memory low, arrhythmia, unstable blood pressure, sexual dysfunction, have a strong impact on life weight.At present, develop part for fatigue preparation, as " a kind of anti-fatigue Chinese medicinal composition and lagehead atractylodes paste " (application number is 201010128061.8), mainly formed by the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati Odorati, Pericarpium Citri Reticulatae, improved fatigue from the angle of adjusting taste, digestion promoting." application of a kind of compositions in the medicine of preparation resisting fatigue " (application number is 200510136455.7) is mainly that raw material forms by Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae, Fructus Hippophae, Rhizoma Zingiberis Recens, Herba Cichorii, Fructus Lycii." anti-fatigue medicament and preparation method thereof " (03109331.0), is made up of raw materials such as Radix Panacis Quinquefolii, Semen Cassiae, Fructus Lycii, the Radix Astragali, Radix Polygoni Multiflori Preparata, Fructus Crataegis.
Summary of the invention
The present invention relates to a kind of Chinese medicine composition for the treatment of chronic fatigue syndrome and preparation method thereof.
Implementation of the present invention is:
Described compositions comprises the crude drug of following weight proportion:
100～300 parts of Radix Ginsengs;
200～400 parts of Fructus Lyciis;
100～200 parts of Radix Rhodiolaes;
200～400 parts of Semen Trigonellae.
Preferred: described composition weight proportioning is as follows:
120 parts of Radix Ginsengs;
300 parts of Fructus Lyciis;
150～160 parts of Radix Rhodiolaes;
200 parts of Semen Trigonellae.
Preferred: described composition weight proportioning is as follows:
120 parts of Radix Ginsengs;
300 parts of Fructus Lyciis;
150 parts of Radix Rhodiolaes;
200 parts of Semen Trigonellae.
Or described composition weight proportioning is as follows:
120 parts of Radix Ginsengs;
300 parts of Fructus Lyciis;
200 parts of Radix Rhodiolaes;
200 parts of Semen Trigonellae.
The invention still further relates to a kind of preparation method of composition for the treatment of chronic fatigue syndrome, Radix Ginseng extract, wolfberry fruit extract, Radix Rhodiolae extract, Semen Trigonellae extract are added in boiling water and dissolved, add sugar, stabilizing agent to allocate to obtain solution simultaneously.
Concrete, the preparation method of described compositions comprises the steps:
(1) allotment: get Radix Ginseng, Fructus Lycii, Radix Rhodiolae, Semen Trigonellae extract by formula, add and be equivalent to fully dissolve in extract gross weight 5-20 boiling water doubly, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring;
(2) filter: seasoning liquid is crossed 2-10 μ m filter plate under 0.2-0.3 MPa;
(3) subsequent process: filtrate is cooled to 30-50 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12-0.15 MPa.
The invention still further relates to a kind of preparation method of Chinese medicine composition for the treatment of chronic fatigue syndrome.Preparation method of the present invention comprises the steps:
Getting Radix Ginseng, Fructus Lycii, Radix Rhodiolae, Semen Trigonellae decoction pieces decocts with water, filters; Merge twice and decoct gained filtrate, the extractum of concentrated proportion 1.1-1.2, adds dissolve with ethanol extractum to remove insoluble polysaccharide, and after plate-and-frame filtration, low-temperature reduced-pressure reclaims ethanol; Extract dissolves under the state of continuous heating in boiling water, adds sugar, stabilizing agent to allocate to obtain solution simultaneously.
Concrete, described compositions prepares by the following method:
(1) extract: get Radix Ginseng, Fructus Lycii, Radix Rhodiolae, Semen Trigonellae decoction pieces by formula and add and be equivalent to the decocting that decoction pieces gross weight 5-10 doubly measures and boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merge twice and decoct gained filtrate, the extractum of concentrated proportion 1.1-1.2, add extractum weight 5-10 ethanol doubly to dissolve extractum to remove insoluble polysaccharide at 65 ℃ of 60-, after 50-100 μ m filter plate filters, low-temperature reduced-pressure reclaims ethanol;
(3) allotment, to obtain final product.
Preferably, the described allotment of step (3) is: get the extract that step (2) makes, join and be equivalent to fully dissolve in extract gross weight 5-20 boiling water doubly, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring; Seasoning liquid is crossed 2-10 μ m filter plate under 0.2-0.3 MPa; Filtrate is cooled to 30-50 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12-0.15 MPa.
Described sugar is one or more in high fructose syrup, maltitol syrup or Mel; Described stabilizing agent is one or more in arabic gum, xanthan gum or Tragacanth.
Radix Ginseng is famous tonification class Chinese medicine, has strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promotes the production of body fluid and nourish blood, calm the nerves the function of Fructus Alpiniae Oxyphyllae.Modern pharmacology studies have shown that, ginsenoside and polysaccharide composition have significant antifatigue effect.Fructus Lycii has the function of nourishing the liver and kidney, replenishing vital essence to improve eyesight, and verified lycium barbarum polysaccharide has the effect that improves male's fatigue state.Chinese medical theory thinks, Semen Trigonellae has warming the kidney to activate YANG, the function of the pain relieving of dispeling cold, and part pharmacology of Chinese materia medica studies have shown that, the Chinese medicine preparation that contains Semen Trigonellae has the effect of resisting fatigue more.Radix Rhodiolae is famous acrophyta, is all bringing into play significant effect at aspects such as resisting fatigue, anoxia enduring, antioxidation.
The present invention has splendid curative effect, especially male patient to suffering from the patient of chronic fatigue syndrome.This product mouthfeel is good, absorption is rapid, and scientific formulation is reasonable, and preparation method is simple.
In addition, the method of checking by enhancing immunity function assessment, the compositions that further checking the present invention relates to and the effect of preparation thereof, the method for " health food check and assessment technique standard (version in 2003) " that test method is promulgated with reference to Ministry of Health of the People's Republic of China operates.Concrete experimental technique and result are as follows:
The method of checking by enhancing immunity function assessment, further verifies effect of the present invention, and the method for " health food check and assessment technique standard (version in 2003) " that test method is promulgated with reference to Ministry of Health of the People's Republic of China operates.
60 of the male SD mices of clean level of laboratory animal selection quality (18-22g), are divided into four groups, 15 every group at random.Take human body day dose (40g/60kg body weight) as reference, three dosage groups (be equivalent to respectively human body recommended dose 5 times, 10 times, 20 times) are set: 3.5g/kg, 7g/kg, 14g/kg, and a negative control group.Prepare sample according to the embodiment of the present invention 1, before every day gavage 12 hours on an empty stomach, every day gavage once, continue 30 days.
Last is fed after sample after 30min, and load 1g sheet lead mice is placed in to swimming trunk went swimming.Found that, the swimming time that gives the middle high dose group mice of present composition preparation all obviously extends, and is respectively 2.5 times of negative control group and 3.5 times.Prove thus, compositions involved in the present invention and preparation thereof are obvious to improving fatigue effect.
The specific embodiment
embodiment 1
(1) allotment: take by weight 100 parts of Radix Ginsengs, 200 parts of Fructus Lyciis, 200 parts of Radix Rhodiolaes, 400 parts of extracts of Semen Trigonellae, add in the boiling water that is equivalent to 5 times of extract gross weights and fully dissolve, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring;
(2) filter: seasoning liquid is crossed 2 μ m filter plates under 0.2MPa;
(3) subsequent process: filtrate is cooled to 30 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12 MPa.
embodiment 2
(1) allotment: take by weight 150 parts of Radix Ginsengs, 240 parts of Fructus Lyciis, 180 parts of Radix Rhodiolaes, 380 parts of extracts of Semen Trigonellae, add in the boiling water that is equivalent to 5 times of extract gross weights and fully dissolve, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring;
(2) filter: seasoning liquid is crossed 4 μ m filter plates under 0.3MPa;
(3) subsequent process: filtrate is cooled to 40 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.14MPa.
embodiment 3
(1) allotment: take by weight 180 parts of Radix Ginsengs, 280 parts of Fructus Lyciis, 180 parts of Radix Rhodiolaes, 380 parts of extracts of Semen Trigonellae, add in the boiling water that is equivalent to 5 times of extract gross weights and fully dissolve, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring;
(2) filter: seasoning liquid is crossed 2 μ m filter plates under 0.2MPa;
(3) subsequent process: filtrate is cooled to 50 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12 MPa.
embodiment 4
(1) allotment: take by weight 120 parts of Radix Ginsengs, 300 parts of Fructus Lyciis, 200 parts of Radix Rhodiolaes, 200 parts of extracts of Semen Trigonellae, add in the boiling water that is equivalent to 8 times of extract gross weights and fully dissolve, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring;
(2) filter: seasoning liquid is crossed 10 μ m filter plates under 0.2MPa;
(3) subsequent process: filtrate is cooled to 40 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.15MPa.
embodiment 5
(1) allotment: take by weight 120 parts of Radix Ginsengs, 300 parts of Fructus Lyciis, 150 parts of Radix Rhodiolaes, 200 parts of extracts of Semen Trigonellae, add in the boiling water that is equivalent to 8 times of extract gross weights and fully dissolve, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring;
(2) filter: seasoning liquid is crossed 6 μ m filter plates under 0.2MPa;
(3) subsequent process: filtrate is cooled to 30 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12 MPa.
embodiment 6
(1) allotment: take by weight 200 parts of Radix Ginsengs, 320 parts of Fructus Lyciis, 140 parts of Radix Rhodiolaes, 180 parts of extracts of Semen Trigonellae, add in the boiling water that is equivalent to 10 times of extract gross weights and fully dissolve, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring;
(2) filter: seasoning liquid is crossed 8 μ m filter plates under 0.2MPa;
(3) subsequent process: filtrate is cooled to 30 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.15MPa.
embodiment 7
(1) allotment: take by weight 230 parts of Radix Ginsengs, 340 parts of Fructus Lyciis, 140 parts of Radix Rhodiolaes, 180 parts of extracts of Semen Trigonellae, add in the boiling water that is equivalent to 10 times of extract gross weights and fully dissolve, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring;
(2) filter: seasoning liquid is crossed 2 μ m filter plates under 0.2MPa;
(3) subsequent process: filtrate is cooled to 30 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12 MPa.
embodiment 8
(1) allotment: take by weight 250 parts of Radix Ginsengs, 370 parts of Fructus Lyciis, 150 parts of Radix Rhodiolaes, 180 parts of extracts of Semen Trigonellae, add in the boiling water that is equivalent to 5 times of extract gross weights and fully dissolve, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring;
(2) filter: seasoning liquid is crossed 6 μ m filter plates under 0.3MPa;
(3) subsequent process: filtrate is cooled to 40 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.15MPa.
embodiment 9
(1) allotment: take by weight 250 parts of Radix Ginsengs, 320 parts of Fructus Lyciis, 140 parts of Radix Rhodiolaes, 280 parts of extracts of Semen Trigonellae, add in the boiling water that is equivalent to 5 times of extract gross weights and fully dissolve, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring;
(2) filter: seasoning liquid is crossed 2 μ m filter plates under 0.2MPa;
(3) subsequent process: filtrate is cooled to 30 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12 MPa.
embodiment 10
(1) allotment: take by weight 270 parts of Radix Ginsengs, 350 parts of Fructus Lyciis, 120 parts of Radix Rhodiolaes, 380 parts of extracts of Semen Trigonellae, add in the boiling water that is equivalent to 5 times of extract gross weights and fully dissolve, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring;
(2) filter: seasoning liquid is crossed 8 μ m filter plates under 0.2MPa;
(3) subsequent process: filtrate is cooled to 30 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.15MPa.
embodiment 11
(1) extract: take by weight 300 parts of Radix Ginsengs, 200 parts of Fructus Lyciis, 140 parts of Radix Rhodiolaes, 400 parts of extracts of Semen Trigonellae, add the decocting that is equivalent to 5 times of amounts of crude drug gross weight to boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merges twice and decoct gained filtrate, the extractum of concentrated proportion 1.1, adds the ethanol of 5 times of extractum weight to dissolve extractum to remove insoluble polysaccharide at 60 ℃, after 50 μ m filter plates filter, low-temperature reduced-pressure recovery ethanol;
(3) allotment: extract dissolves under the state of continuous heating in boiling water, adds sugar, stabilizing agent to allocate simultaneously, and continues to stir.
(4) filter: seasoning liquid is crossed 2 μ m filter plates under 0.2MPa;
(5) subsequent process: filtrate is cooled to 30 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12MPa.
embodiment 12
(1) extract: take by weight 300 parts of Radix Ginsengs, 320 parts of Fructus Lyciis, 140 parts of Radix Rhodiolaes, 200 parts of extracts of Semen Trigonellae, add the decocting that is equivalent to 8 times of amounts of crude drug gross weight to boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merges twice and decoct gained filtrate, the extractum of concentrated proportion 1.1, adds the ethanol of 5 times of extractum weight to dissolve extractum to remove insoluble polysaccharide at 65 ℃, after 70 μ m filter plates filter, low-temperature reduced-pressure recovery ethanol;
(3) allotment: extract dissolves under the state of continuous heating in boiling water, adds sugar, stabilizing agent to allocate simultaneously, and continues to stir.
(4) filter: seasoning liquid is crossed 2 μ m filter plates under 0.2MPa;
(5) subsequent process: filtrate is cooled to 30 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12MPa.
embodiment 13
(1) extract: take by weight 240 parts of Radix Ginsengs, 300 parts of Fructus Lyciis, 170 parts of Radix Rhodiolaes, 210 parts of extracts of Semen Trigonellae, add the decocting that is equivalent to 10 times of amounts of crude drug gross weight to boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merges twice and decoct gained filtrate, the extractum of concentrated proportion 1.2, adds the ethanol of 8 times of extractum weight to dissolve extractum to remove insoluble polysaccharide at 65 ℃, after 80 μ m filter plates filter, low-temperature reduced-pressure recovery ethanol;
(3) allotment: extract dissolves under the state of continuous heating in boiling water, adds sugar, stabilizing agent to allocate simultaneously, and continues to stir.
(4) filter: seasoning liquid is crossed 6 μ m filter plates under 0.3MPa;
(5) subsequent process: filtrate is cooled to 40 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12MPa.
embodiment 14
(1) extract: take by weight 120 parts of Radix Ginsengs, 370 parts of Fructus Lyciis, 160 parts of Radix Rhodiolaes, 240 parts of extracts of Semen Trigonellae, add the decocting that is equivalent to 10 times of amounts of crude drug gross weight to boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merges twice and decoct gained filtrate, the extractum of concentrated proportion 1.1, adds the ethanol of 5 times of extractum weight to dissolve extractum to remove insoluble polysaccharide at 60 ℃, after 50 μ m filter plates filter, low-temperature reduced-pressure recovery ethanol;
(3) allotment: extract dissolves under the state of continuous heating in boiling water, adds sugar, stabilizing agent to allocate simultaneously, and continues to stir.
(4) filter: seasoning liquid is crossed 2 μ m filter plates under 0.2MPa;
(5) subsequent process: filtrate is cooled to 50 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.15 MPa.
embodiment 15
(1) extract: take by weight 150 parts of Radix Ginsengs, 260 parts of Fructus Lyciis, 140 parts of Radix Rhodiolaes, 180 parts of extracts of Semen Trigonellae, add the decocting that is equivalent to 5 times of amounts of crude drug gross weight to boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merges twice and decoct gained filtrate, the extractum of concentrated proportion 1.1, adds the ethanol of 5 times of extractum weight to dissolve extractum to remove insoluble polysaccharide at 60 ℃, after 100 μ m filter plates filter, low-temperature reduced-pressure recovery ethanol;
(3) allotment: extract dissolves under the state of continuous heating in boiling water, adds sugar, stabilizing agent to allocate simultaneously, and continues to stir.
(4) filter: seasoning liquid is crossed 10 μ m filter plates under 0.2MPa;
(5) subsequent process: filtrate is cooled to 50 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12MPa.
embodiment 16
(1) extract: take by weight 160 parts of Radix Ginsengs, 320 parts of Fructus Lyciis, 190 parts of Radix Rhodiolaes, 180 parts of extracts of Semen Trigonellae, add the decocting that is equivalent to 10 times of amounts of crude drug gross weight to boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merges twice and decoct gained filtrate, the extractum of concentrated proportion 1.1, adds the ethanol of 5 times of extractum weight to dissolve extractum to remove insoluble polysaccharide at 60 ℃, after 80 μ m filter plates filter, low-temperature reduced-pressure recovery ethanol;
(3) allotment: extract dissolves under the state of continuous heating in boiling water, adds sugar, stabilizing agent to allocate simultaneously, and continues to stir.
(4) filter: seasoning liquid is crossed 2 μ m filter plates under 0.3MPa;
(5) subsequent process: filtrate is cooled to 40 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12MPa.
embodiment 17
(1) extract: take by weight 180 parts of Radix Ginsengs, 300 parts of Fructus Lyciis, 140 parts of Radix Rhodiolaes, 200 parts of extracts of Semen Trigonellae, add the decocting that is equivalent to 5 times of amounts of crude drug gross weight to boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merges twice and decoct gained filtrate, the extractum of concentrated proportion 1.1, adds the ethanol of 5 times of extractum weight to dissolve extractum to remove insoluble polysaccharide at 60 ℃, after 50 μ m filter plates filter, low-temperature reduced-pressure recovery ethanol;
(3) allotment: extract dissolves under the state of continuous heating in boiling water, adds sugar, stabilizing agent to allocate simultaneously, and continues to stir.
(4) filter: seasoning liquid is crossed 2 μ m filter plates under 0.2MPa;
(5) subsequent process: filtrate is cooled to 30 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12MPa.
embodiment 18
(1) extract: take by weight 200 parts of Radix Ginsengs, 220 parts of Fructus Lyciis, 200 parts of Radix Rhodiolaes, 280 parts of extracts of Semen Trigonellae, add the decocting that is equivalent to 10 times of amounts of crude drug gross weight to boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merges twice and decoct gained filtrate, the extractum of concentrated proportion 1.2, adds the ethanol of 10 times of extractum weight to dissolve extractum to remove insoluble polysaccharide at 60 ℃, after 80 μ m filter plates filter, low-temperature reduced-pressure recovery ethanol;
(3) allotment: extract dissolves under the state of continuous heating in boiling water, adds sugar, stabilizing agent to allocate simultaneously, and continues to stir.
(4) filter: seasoning liquid is crossed 10 μ m filter plates under 0.3MPa;
(5) subsequent process: filtrate is cooled to 50 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12MPa.
embodiment 19
(1) extract: take by weight 220 parts of Radix Ginsengs, 390 parts of Fructus Lyciis, 190 parts of Radix Rhodiolaes, 250 parts of extracts of Semen Trigonellae, add the decocting that is equivalent to 8 times of amounts of crude drug gross weight to boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merges twice and decoct gained filtrate, the extractum of concentrated proportion 1.1, adds the ethanol of 5 times of extractum weight to dissolve extractum to remove insoluble polysaccharide at 60 ℃, after 50 μ m filter plates filter, low-temperature reduced-pressure recovery ethanol;
(3) allotment: extract dissolves under the state of continuous heating in boiling water, adds sugar, stabilizing agent to allocate simultaneously, and continues to stir.
(4) filter: seasoning liquid is crossed 2 μ m filter plates under 0.2MPa;
(5) subsequent process: filtrate is cooled to 30 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12MPa.
embodiment 20
(1) extract: take by weight 240 parts of Radix Ginsengs, 280 parts of Fructus Lyciis, 150 parts of Radix Rhodiolaes, 180 parts of extracts of Semen Trigonellae, add the decocting that is equivalent to 10 times of amounts of crude drug gross weight to boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merges twice and decoct gained filtrate, the extractum of concentrated proportion 1.1, adds the ethanol of 5 times of extractum weight to dissolve extractum to remove insoluble polysaccharide at 60 ℃, after 100 μ m filter plates filter, low-temperature reduced-pressure recovery ethanol;
(3) allotment: extract dissolves under the state of continuous heating in boiling water, adds sugar, stabilizing agent to allocate simultaneously, and continues to stir.
(4) filter: seasoning liquid is crossed 2 μ m filter plates under 0.3MPa;
(5) subsequent process: filtrate is cooled to 50 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12MPa.
Claims (8)
1. treat a Chinese medicine composition for chronic fatigue syndrome, comprise the crude drug of following weight proportion: 100～300 parts of Radix Ginsengs, 200～400 parts of Fructus Lyciis, 100～200 parts of Radix Rhodiolaes, 200～400 parts of Semen Trigonellae.
2. Chinese medicine composition according to claim 1, is characterized in that, comprises the crude drug of following weight proportion: 120 parts of Radix Ginsengs, 300 parts of Fructus Lyciis, Radix Rhodiolae 150-200 part, 200 parts of Semen Trigonellae.
3. Chinese medicine composition according to claim 1 and 2, is characterized in that, comprises the crude drug of following weight proportion: 120 parts of Radix Ginsengs, 300 parts of Fructus Lyciis, 150 parts of Radix Rhodiolaes, 200 parts of Semen Trigonellae.
4. Chinese medicine composition according to claim 1 and 2, is characterized in that, comprises the crude drug of following weight proportion: 120 parts of Radix Ginsengs, 300 parts of Fructus Lyciis, 200 parts of Radix Rhodiolaes, 200 parts of Semen Trigonellae.
5. the preparation method of Chinese medicine composition described in the arbitrary claim of claim 1-4, comprises the steps:
(1) extract: get Radix Ginseng, Fructus Lycii, Radix Rhodiolae, Semen Trigonellae by formula, add to be equivalent to the decocting that crude drug gross weight 5-10 doubly measures and to boil 2 times, each approximately 1 hour, through plate-and-frame filtration;
(2) except polysaccharide: merge twice and decoct gained filtrate, the extractum of concentrated proportion 1.1-1.2, add extractum weight 5-10 ethanol doubly to dissolve extractum to remove insoluble polysaccharide at 65 ℃ of 60-, after 50-100 μ m filter plate filters, low-temperature reduced-pressure reclaims ethanol;
(3) allotment, to obtain final product.
6. preparation method according to claim 5, it is characterized in that, the described allotment of step (3) is: get the extract that step (2) makes, add and be equivalent to fully dissolve in extract gross weight 5-20 boiling water doubly, add the sugar of water weight 20% and 10% stabilizing agent to allocate 20 minutes simultaneously, keep fluidized state therebetween and continue stirring; Seasoning liquid is crossed 2-10 μ m filter plate under 0.2-0.3 MPa; Filtrate is cooled to 30-50 ℃, fill, sealing, finished product sterilizing 20 minutes under 121 ℃, 0.12-0.15 MPa.
7. preparation method according to claim 6, is characterized in that, described sugar is one or more in high fructose syrup, maltitol syrup or Mel.
8. want the preparation method described in 6 according to right, it is characterized in that, described stabilizing agent is one or more in arabic gum, xanthan gum or Tragacanth.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106690A (en) * | 2015-08-31 | 2015-12-02 | 济南骄泰信息技术有限公司 | Traditional Chinese medicine composition for treating chronic fatigue syndrome |
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| CN105106690A (en) * | 2015-08-31 | 2015-12-02 | 济南骄泰信息技术有限公司 | Traditional Chinese medicine composition for treating chronic fatigue syndrome |
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| CN105641456A (en) * | 2016-03-12 | 2016-06-08 | 梁立周 | Traditional Chinese medicine combination for treating hepatic and renal yin deficiency type chronic fatigue syndrome |
| CN105617114A (en) * | 2016-03-14 | 2016-06-01 | 孙振玲 | Traditional Chinese medicine composition for treating qi-yin deficiency type chronic fatigue syndrome |
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