CN102614412A - Chinese medicinal composition for clearing heat, dispelling wind, relieving convulsion and soothing nerves - Google Patents
Chinese medicinal composition for clearing heat, dispelling wind, relieving convulsion and soothing nerves Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for clearing heat, dispelling wind, relieving convulsion and soothing nerves. The Chinese medicinal composition is characterized by comprising the following active ingredients in percentage by weight: 8-30 percent of amber, 5-20 percent of tabasheer, 5-20 percent of uncaria, 5-20 percent of codonopsis pilosula, 6-25 percent of large-head atractylodes rhizome (fried), 6-25 percent of tuckahoe, 5-20 percent of mint, 2-15 percent of stiff silkworm (fried) and 2-15 percent of seed of wild jujube. The Chinese medicinal composition can be prepared into any oral formulation of powder, granules, capsules, tablets or oral liquid. The Chinese medicinal composition has the effects of clearing heat, dispelling wind, relieving convulsion and soothing nerves, and is used for symptoms such as common cold and fever in children, panic and anxiety, weakness of spleen and stomach, vomiting, diarrhea and the like. Through pharmacological test and clinical curative effect observation, the Chinese medicinal composition has the various advantages of multiple effects, quick response, convenience for taking, easiness for absorption, safety, reliability, no gastrointestinal irritation and the like, and can be used as a clinical preferred medicament for treating syndromes such as common cold and fever in children, panic and night cry, weakness of spleen and stomach, vomiting and diarrhea.
Description
Technical field
The present invention relates to tcm field, be specifically a kind ofly analgesicly dispel the wind, the Chinese medicine composition of tranquillizing the mind by relieving convulsion, be used to treat infantile common cold heating, terrified uneasiness, weakness of the spleen and stomach, vomiting disease such as have loose bowels.
Background technology
The child has huge medication demand as a colony of medicine consumption.According to the appropriate authority preliminary forecasting, child's medicine of China has at least 500 hundred million yuan the market space.Yet alarming is that the medicine of domestic market 90% does not all have child's dosage form.Children does not have child's dosage form, and the pediatrician leans on the experience medication, and potential safety hazard is huge.Though all kinds of child health care article are seen everywhere on the market, the medicine that really is used to treat children disease is very limited.The shortage of children has caused the adult of department of pediatrics medication.The application method that the department of pediatrics medication is calculated according to child's body weight, age or body surface area and adult's ratio is to have treated as scaled adult to the child.Such administrated method is not considered children's's physiological characteristics, i.e. child's drug metabolism is different with the adult, and its liver, kidney etc. all in growth, cause adverse effect easily, children's health have been caused significant damage, science medication far from.Along with the growth of department of pediatrics dosage, be badly in need of the special medicament of exploitation to the child.
In children's that existing market the is sold treatment, its effect of western drug is often more single.And contain Cinnabaris in the prescription of existing this type of disease of treatment more, and Cinnabaris has toxicity, especially the child is had more hazardness, influences its using and promoting clinically.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art, provide a kind of department of pediatrics to use Chinese medicine, have analgesicly dispel the wind, the effect of tranquillizing the mind by relieving convulsion, be used for the infantile common cold heating, terrified uneasy, weakness of the spleen and stomach, vomiting and diarrhoea etc., its determined curative effect, safe without toxic side effect.
Children's is because body and physiogeny are all imperfect, and body constitution belongs to the inmature stage, and is relatively poor to the resistivity of disease, and pathogen is easy to infect, and digestive function of spleen and stomach is weak, so much more comparatively pediatric respiratory system disease, digestive system disease seen.Chinese medicine composition of the present invention has better therapeutic effect to these diseases.Go into conscience two warps with succinum in the side, relieving convulsion, sharp key promoting blood circulation, Concretio Silicea Bambusae, Ramulus Uncariae Cum Uncis are also gone into conscience two warps, can clear its heat and eliminate phlegm for resuscitation, to children's since expectorant heat stop up contain due to infantile convulsion particularly suitable, so be we's monarch drug altogether.The Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, the Poria that are aided with four gentleman are minister, Radix Codonopsis invigorating the spleen and replenishing QI, Rhizoma Atractylodis Macrocephalae invigorating the spleen to arrest diarrhea; Poria helps Rhizoma Atractylodis Macrocephalae spleen invigorating eliminating dampness by diuresis diuresis, and real stool, Bombyx Batryticatus dispels the wind and expels the heat-evil, relieving convulsion reduces phlegm; With the same usefulness of replenishing QI to invigorate the spleen such as Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, with controlling infantile spleen deficiency chronic diarrhea, intermittent infantile convulsion etc.Help the Semen Ziziphi Spinosae tranquilizing by nourishing the heart less, share with succinum, only the throb with fear merit of calming the nerves that it is relieving convulsion is good especially, disperses with the hot cold of Herba Menthae again, and dispelling wind and heat pathogens thinks that assistant makes.So the present invention can train tonifying the spleen and stomach to the gently catharsis clearly of children's wind-heat diseases caused by exogenous pathogenic factor to dysfunction of the spleen in transportation,, impel the peaceful good medicine of children's so be the enhancing body function.
The objective of the invention is to realize through following technical scheme:
Chinese medicine composition of the present invention is processed by following weight parts proportion raw material medicine:
Succinum 8-30%, Concretio Silicea Bambusae 5-20%, Ramulus Uncariae Cum Uncis 5-20%, Radix Codonopsis 5-20%, Rhizoma Atractylodis Macrocephalae 6-25%,
Poria 6-25%, Herba Menthae 5-20%, Bombyx Batryticatus 2-15%, Semen Ziziphi Spinosae 2-15 %
Chinese medicine composition of the present invention also can adopt the raw material of following preferred weight ratio to form:
Be succinum 10-25%, Concretio Silicea Bambusae 6-18%, Ramulus Uncariae Cum Uncis 6-18%, Radix Codonopsis 6-18%, Rhizoma Atractylodis Macrocephalae 8-20% Poria 8-20%, Herba Menthae 6-15%, Bombyx Batryticatus 3-12%, Semen Ziziphi Spinosae 3-12%
Most preferred weight proportion of the present invention is following:
Succinum 15-20%, Concretio Silicea Bambusae 8-12%, Ramulus Uncariae Cum Uncis 8-12%, Radix Codonopsis 8-12%, Rhizoma Atractylodis Macrocephalae 12-18% Poria 12-18%, Herba Menthae 8-12%, Bombyx Batryticatus 5-10%, Semen Ziziphi Spinosae 5-10%
The Rhizoma Atractylodis Macrocephalae described in the present invention, Bombyx Batryticatus preferably adopt frying production method to concoct.
Of the present inventionly be used to treat infantile common cold heating; Terrified uneasy; Weakness of the spleen and stomach, the Chinese medicine composition of diseases such as vomiting and diarrhoea can be processed through following technology and be fit to medicinal dosage form, and specifically said dosage form is peroral dosage forms commonly used such as powder, granule, capsule, tablet, oral liquid.Its preparation method can adopt following step to realize:
(1) by weight getting above-mentioned each component raw material, be ground into fine powder with high speed disintegrator, sieve, mixing obtains the medicated powder I;
(2) by weight getting succinum, Concretio Silicea Bambusae, Ramulus Uncariae Cum Uncis and Poria, be ground into fine powder with high speed disintegrator, sieve, mixing obtains the medicated powder II;
(3) by weight getting the Rhizoma Atractylodis Macrocephalae, Herba Menthae water distillating extracting oil, obtain volatile oil;
(4) Rhizoma Atractylodis Macrocephalae, Herba Menthae extract medicinal residues and Radix Codonopsis, Bombyx Batryticatus (stir-frys), the Semen Ziziphi Spinosae decocte with water 2 times behind the volatile oil, merge decoction liquor, consider, and it is concentrated to filtrate, and remove impurity obtains medicinal liquid A;
(5) Rhizoma Atractylodis Macrocephalae, Herba Menthae extract medicinal residues and Concretio Silicea Bambusae, Radix Codonopsis, Poria, Bombyx Batryticatus (stir-frys), the Semen Ziziphi Spinosae decocte with water (after waiting to boil, adding succinum and Ramulus Uncariae Cum Uncis again) 2 times behind the volatile oil, merge decoction liquor, consider, and it is concentrated to filtrate, and remove impurity obtains medical liquid B;
(6) directly get it filled powder I or in the medicated powder I, add pharmaceutically acceptable carrier is mixed, and processes powder, granule, capsule and tablet; Or, add pharmaceutically acceptable carrier with above-mentioned medicated powder II, volatile oil, medicinal liquid A mixing, process granule, tablet, capsule; Or, add pharmaceutically acceptable carrier with above-mentioned medical liquid B, volatile oil mixing, process oral liquid.
The efficacy effect of each raw material described in the Chinese medicine composition of the present invention is following:
Succinum, sweet, flat, it is relieving convulsion to calm the nerves, and diuresis of blood circulation promoting is used for palpitation and insomnia, convulsion with spasms, epilepsy, dysuria, hematuria, dysurea.The Concretio Silicea Bambusae clear heat and eliminate phlegm, cool heart arresting convulsion is used for the calentura coma, middle wind-phlegm fan, the hot infantile convulsion of children's's expectorant, tic, night cry.The Ramulus Uncariae Cum Uncis arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., the heat clearing away suppressing the hyperactive liver is used for liver-wind stirring up internally, and infantile convulsion is twitched, hyperpyrexia convulsion, dysphoric cold, children's's nights crying due to fright in infant etc. have calmness and anticonvulsant action.Radix Codonopsis spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid is used for deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood etc.The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, the dampness diuretic, and hidroschesis, antiabortive effect is used for insufficiency of the spleen lack of appetite, and abdominal distention is had loose bowels, the phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement, and can the enhancing human body immunity function.The Herba Menthae dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, soothing liver-QI circulation of qi promoting.Be used for anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast side of body feeling of distension and oppression.Bombyx Batryticatus endogenous wind stopping relieving convulsion, wind-expelling pain-stopping, dissipating phlegm and resolving masses, it is frightened to be used for the liver-wind folder, and infantile convulsion is twitched, acute infantile convulsion etc.The Semen Ziziphi Spinosae tonifying liver that nourishes heart, mind tranquilizing and the heart calming, arresting sweating promotes the production of body fluid.Be used for restlessness of asrhenia type and insomnia, the palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Advantage of the present invention and beneficial effect are:
The present invention is guidance with the theory of Chinese medical science, and compatibility is tight, and rationally each medicine is learnt from other's strong points to offset one's weaknesses, and takes into account comprehensively, gives full play to the synergism between each medicine.Have through this Chinese medicine composition of pharmacological testing and clinical observation on the therapeutic effect proof analgesicly dispel the wind, the function of tranquillizing the mind by relieving convulsion, to the common disease of children's, like weakness of the spleen and stomach, palpitation with fear is uneasy, diseases such as cold, fever and convulsion with spasms have definite curative effect.It is many that this invention has effect, instant effect, and taking convenience is prone to absorb, and is safe and reliable, do not have plurality of advantages such as any gastrointestinal irritation property, can be used as the clinical first-selected medication of comprehensive cards such as the heating of treatment infantile common cold, terrified night cry, weakness of the spleen and stomach, vomiting and diarrhoea.
The specific embodiment
To combine embodiment to further describe below the present invention; But the scheme of said embodiment does not limit the present invention; One of skill in the art can make improvements and change according to scheme of the present invention, and described these improvement and variation all should be regarded as within the scope of the invention.
Embodiment 1
The preparation technology of drug powder of the present invention is following:
By weight getting succinum 17%, Concretio Silicea Bambusae 10%, Ramulus Uncariae Cum Uncis 10%, Radix Codonopsis 10%, the Rhizoma Atractylodis Macrocephalae (stir-fry) 14.5 %, Poria 14.5%, Herba Menthae 10%, Bombyx Batryticatus (stir-fry) 7.5%, Semen Ziziphi Spinosae 7.5 %; Be ground into fine powder with high speed disintegrator, sieve, mixing; Packing promptly gets.
Embodiment 2
The preparation technology of drug powder of the present invention is following:
By weight getting succinum 10%, Concretio Silicea Bambusae 12%, Ramulus Uncariae Cum Uncis 12%, Radix Codonopsis 12%, the Rhizoma Atractylodis Macrocephalae (stir-fry) 16 %, Poria 16%, Herba Menthae 12%, Bombyx Batryticatus (stir-fry) 5%, Semen Ziziphi Spinosae 5 %, be ground into fine powder with high speed disintegrator, sieve, mixing, packing promptly gets.
Embodiment 3
The preparation technology of medicinal granule of the present invention is following:
By weight getting succinum 17%, Concretio Silicea Bambusae 10%, Ramulus Uncariae Cum Uncis 10%, Poria 14.5%, be ground into fine powder with high speed disintegrator, sieve, mixing obtains medicated powder, and is subsequent use; Get the Rhizoma Atractylodis Macrocephalae 14.5 %, Herba Menthae 10 % water distillating extracting oils, subsequent use; The Rhizoma Atractylodis Macrocephalae, Herba Menthae extract medicinal residues and Radix Codonopsis 10%, Bombyx Batryticatus (stir-frys) 7.5%, Semen Ziziphi Spinosae 7.5% decocte with water 2 times behind the volatile oil, merge decoction liquor, consider, and it is concentrated to filtrate, and obtains ointment; Adding suitable amount of sucrose and dextrin in the ointment are mixed with above-mentioned medicated powder, process granule, drying adds volatile oil, and mixing is processed 1000g, and packing promptly gets.
Embodiment 4
The preparation technology of medicine oral liquid of the present invention is following:
By weight getting the Rhizoma Atractylodis Macrocephalae 10%, Herba Menthae 7 % water distillating extracting oils, subsequent use; The Rhizoma Atractylodis Macrocephalae, Herba Menthae extract medicinal residues and Concretio Silicea Bambusae 15%, Radix Codonopsis 8%, Poria 12%, Bombyx Batryticatus (stir-frys) 10%, Semen Ziziphi Spinosae 10% decocte with water (after waiting to boil, adding succinum 20% and Ramulus Uncariae Cum Uncis 8%) 2 times behind the volatile oil, and the merging decoction liquor was considered; Filtrating concentrates, and remove impurity adds an amount of correctives and above-mentioned volatile oil, regulates pH value to 7.0 with 20% sodium hydroxide solution; Add water to 1000ml, stir, considered; Embedding, sterilization promptly gets.
Embodiment 5
The preparation technology of medicine capsule of the present invention is following:
By weight getting succinum 15%, Concretio Silicea Bambusae 6%, Ramulus Uncariae Cum Uncis 15%, Poria 10%, be ground into fine powder with high speed disintegrator, sieve, mixing obtains medicated powder, and is subsequent use; Get the Rhizoma Atractylodis Macrocephalae 16 %, Herba Menthae 8 % water distillating extracting oils, subsequent use; The Rhizoma Atractylodis Macrocephalae, Herba Menthae extract medicinal residues and Radix Codonopsis 16%, Bombyx Batryticatus (stir-frys) 6%, Semen Ziziphi Spinosae 8% decocte with water 2 times behind the volatile oil, merge decoction liquor, consider, and filtrating is concentrated in right amount; Be mixed and made into granule with above-mentioned medicated powder, drying sprays into volatile oil, and mixing incapsulates, and processes 1000, promptly gets.
Come further to embody excellent results of the present invention through concrete test data below.
One, pharmacodynamics test
1. the influence test of medicinal granule of the present invention to generating heat due to the yeast
Get 50 of rats, divide equally 5 groups at random, be respectively matched group; Medicinal granule of the present invention 7.04,3.52,1.76g/kg, five groups of peaceful powder 7.04 g/kg of doll, animal before pyrogenicity 48,24h is administered twice; Every Mus back subcutaneous injection 25% dried yeast powder suspension 20ml/kg pyrogenicity; 1h is administered once again after the pyrogenicity, and after the pyrogenicity 4,6,8,10h surveys the anus temperature, the result sees table 1.
Annotate: with matched group relatively * P 0.05, * * P < 0.01
The result shows, granule 7.04g/kg, 3.52g/kg, the peaceful 7.04g/kg of doll after pyrogenicity 4,6h has the obvious suppression effect to rat fever due to the yeast, granule 7.04g/kg is approaching with the peaceful 7.04g/kg effect of doll.
2. the pharmacodynamics test of spleen deficiency
Choose 120 of body weight 20 ± 2 g healthy mices, male and female half and half are divided and are carried out for 2 times, are divided into 6 groups at random, 10 every group at every turn.⑴ Radix Et Rhizoma Rhei is insufficiency of the spleen gives mice oral administration gavage 100% Radix Et Rhizoma Rhei decocting liquid 0. 5 ml/ group morning every day only 1 time, irritates clothes water 0. 5 ml/ afternoon only 1 time; ⑵ basic, normal, high three kinds of this medicinal granule of dosage treatment groups are only given 12. 5%, 25% and 50% medicinal granule aqueous solution 0. 5 ml/ of mouse gavaging morning every day; ⑶ positive control drug group: irritate clothes with the peaceful suspension of volume doll by 10. 56 g/ kg dosage; ⑷ blank group: give the same water by volume of mouse gavaging respectively in morning every day, afternoon.By above-mentioned dosage administration every day 1 time, continuous 10 days, tested after the last administration 1 hour at every turn; Do following test: 1) resisting fatigue: 6 groups of mices are put into water totally; The depth of water 30 cm, water temperature keeps 28 ~ 30 ℃, sinks to mice water-bedly unablely to be the time of being drowned towards time-out again; Record is its swimming time from entry to the time of being drowned, and the result sees table 2.2) to the influence of intestinal tympanites takes place: weigh after 1 hour in the last administration and to put to death mice; Dissecting inspection intestinal tympanites generation number rapidly, ileum and nearly ileum end are put into water, is small intestinal flatulence with the person of bubbling through the water column; Be flatulence not with its sinking person, its result sees table 3.
The result shows: medicine of the present invention is to the insufficiency of the spleen obvious therapeutic action that truly has of Radix Et Rhizoma Rhei induced mice.
Two, clinical observation on the therapeutic effect
Select this Chinese medicinal composition granules for use, the terrified night cry of children's, diarrhea due to hypofunction of the spleen are carried out 160 routine clinical observations altogether, wherein 120 examples, matched group 40 examples are organized in treatment.Observe the other drug of stopping using therebetween.The result is following:
1, total obvious effective rate of treatment terrified night cry of children's and diarrhea due to hypofunction of the spleen is 81.5%, and total effective rate is 93.26%.
2, the effective percentage of treatment terrified night cry of children's and diarrhea due to hypofunction of the spleen is respectively 92% and 95%, has the effect of tranquillizing the mind by relieving convulsion, invigorating the spleen to arrest diarrhea.
3, children's is twitched due to terrified, the effective percentage of heating paresthesia is respectively 72.24% and 86.36%.Infantile common cold is held under the arm frightened effective percentage with cold, fever be respectively 92% and 84.91%.
Claims (4)
- One kind analgesicly dispel the wind, the Chinese medicine composition of tranquillizing the mind by relieving convulsion, it is characterized in that: raw materials of effective components is formed and weight ratio is: succinum 8-30%, Concretio Silicea Bambusae 5-20%, Ramulus Uncariae Cum Uncis 5-20%, Radix Codonopsis 5-20%, Rhizoma Atractylodis Macrocephalae 6-25%, Poria 6-25%, Herba Menthae 5-20%, Bombyx Batryticatus 2-15%, Semen Ziziphi Spinosae 2-15% in this medicine.
- 2. according to claim 1ly analgesicly dispel the wind, the Chinese medicine composition of tranquillizing the mind by relieving convulsion, it is characterized in that: raw materials of effective components is formed and weight ratio is: succinum 10-25%, Concretio Silicea Bambusae 6-18%, Ramulus Uncariae Cum Uncis 6-18%, Radix Codonopsis 6-18%, Rhizoma Atractylodis Macrocephalae 8-20%, Poria 8-20%, Herba Menthae 6-15%, Bombyx Batryticatus 3-12%, Semen Ziziphi Spinosae 3-12% in this medicine.
- 3. according to claim 2ly analgesicly dispel the wind, the Chinese medicine composition of tranquillizing the mind by relieving convulsion, it is characterized in that: raw materials of effective components is formed and weight ratio is: succinum 15-20%, Concretio Silicea Bambusae 8-12%, Ramulus Uncariae Cum Uncis 8-12%, Radix Codonopsis 8-12%, Rhizoma Atractylodis Macrocephalae 12-18%, Poria 12-18% Herba Menthae 8-12%, Bombyx Batryticatus 5-10%, Semen Ziziphi Spinosae 5-10% in this medicine.
- According to claim 1 or 2 or 3 describedly analgesicly dispel the wind, the Chinese medicine composition of tranquillizing the mind by relieving convulsion, it is characterized in that: process any one peroral dosage form that is fit in medicinal powder, granule, capsule, tablet or the oral liquid by common process.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105853528A (en) * | 2016-06-03 | 2016-08-17 | 陈瑞 | Wild jujube extract for treating cold |
| CN107823483A (en) * | 2017-12-04 | 2018-03-23 | 黑龙江参鸽药业有限公司 | A kind of Chinese medicine composition and preparation method thereof |
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- 2012-04-27 CN CN201210126855XA patent/CN102614412A/en active Pending
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853528A (en) * | 2016-06-03 | 2016-08-17 | 陈瑞 | Wild jujube extract for treating cold |
| CN107823483A (en) * | 2017-12-04 | 2018-03-23 | 黑龙江参鸽药业有限公司 | A kind of Chinese medicine composition and preparation method thereof |
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Application publication date: 20120801 |