CN102008643B - Mixture for treating panasthenia - Google Patents
Mixture for treating panasthenia Download PDFInfo
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- CN102008643B CN102008643B CN2010105804063A CN201010580406A CN102008643B CN 102008643 B CN102008643 B CN 102008643B CN 2010105804063 A CN2010105804063 A CN 2010105804063A CN 201010580406 A CN201010580406 A CN 201010580406A CN 102008643 B CN102008643 B CN 102008643B
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Abstract
The invention relates to a mixture for treating panasthenia, which comprises the following raw material medicaments in part by weight: 13 to 17 parts of tuber fleeceflower stem, 13 to 17 parts of silktree albizzia bark, 1 to 5 parts of grassleaf sweelflag rhizome, 13 to 17 parts of hairyvein agrimonia herb and bud, 13 to 17 parts of coral ardisia root, 13 to 17 parts of fragrant solomonseal rhizome, 13 to 17 parts of young leonurus and 13 to 17 parts of spanishneedles herb. The invention also provides the application of the mixture for treating the panasthenia. The mixture has the advantages that: the compatibility is based on the principle of 'monarch, minister, assistant and guide' of traditional Chinese medicine; pharmacodynamic experiments prove that the mixture has the obvious effect of nourishing heart blood, tranquilizing mind, relieving dysphoria, dispelling melancholy and inducing resuscitation; the mixture is mainly used for the neurasthenia, insomnia, dreaminess, dysphoria and amnesia; and the mixture has no obvious adverse effect, small toxic and side effect, a small medicament number and a good curative effect, is suitable for long-term administration, and is safe and effective.
Description
Technical field
The present invention relates to neurasthenic mixture of a kind of treatment and application thereof, specifically, is to be the Chinese patent medicine of feedstock production with the Chinese herbal medicine.
Background technology
The neurasthenia mainly shows as the imbalance of brain higher nervous activity, and be characterized in normal sensation mentality and be short of physical strength, fatiguability, work efficiency is low, exists but there is organic disease.Various incompatibility symptoms can appear clinically, as dizzy, feel dizzy, sore waist and aching in the waist and the back, irritated irritability, difficulty falling asleep, dreaming often and waking easily, insomnia forgetfulness, premature ejaculation sexual impotence, can be with slight depression or anxiety.Data shows that work, study hypertonicity are acted hurriedly in a messy situation, and it is irregular to have a rest and sleep, and operating pressure is big, and health is in subhealth state, and feels to have burden and offending emotion etc., is to cause neurasthenic principal element.
The western medical treatment neurasthenia mainly relies on to stabilize and waits the tranquilizer symptomatic treatment of sleeping peacefully, but there is defective in these medicines aspect safety and the dependency, and side effect is bigger, forms addiction property, drug resistance easily, so should not take for a long time.
Chinese medicine thinks, diseases such as insomnia, forgetful, dizzy, spiritlessness and weakness, soreness of the waist and knees appear in neurastheniac, surely belong to " being insomnia " disease category.It is often can not obtain a kind of disease that ortho sleep is a characteristic.Be insomnia with the passing of time visceral dysfunction.Its concentrated reflection is on the heart, liver, spleen, lung, all dirty functional disorders of kidney.So the five internal organs are become estranged, the vital essence blood deficiency is its main etiology and pathogenesis, and is wherein close with heart kidney relation especially.Clinically, though the neurasthenia has the branch of deficiency and excess, see so that deficient syndrome more.The neurasthenia is normally with reinforce insufficiency and reduce excessiveness in the Chinese medicine treatment, regulating YIN and YANG, the calm principle that is of calming the nerves.Be used to treat neurasthenic Chinese patent medicine at present clinically Cinnabaris repose ball, nourishing blood to tranquillize the mind sheet, ZAOREN ANSHEN YE or the like are arranged.These medicines all have certain curative effect to the neurasthenia, but also have some problems, and slow like some drug effect, flavour of a drug are more, are not easy to preparation and use, and effect is not fairly obvious, and Time of Administration is long, and curative effect is unstable or the like.
Summary of the invention
The objective of the invention is provides a kind of treatment neurasthenic mixture to deficiency of the prior art.
One purpose more of the present invention is that a kind of purposes of treating neurasthenic mixture is provided.
For realizing above-mentioned purpose; The technical scheme that the present invention takes is: the neurasthenic mixture of a kind of treatment, described mixture is processed by following bulk drugs: Caulis Polygoni Multiflori 13-17 part, Cortex Albiziae 13-17 part, Rhizoma Acori Graminei 1-5 part, Herba Agrimoniae 13-17 part, PINGDIMU 13-17 part, Rhizoma Polygonati Odorati 13-17 part, boy's Herba Leonuri 13-17 part, Herba Bidentis Bipinnatae 13-17 part.
Described mixture is processed by following bulk drugs: Caulis Polygoni Multiflori 14-16 part, Cortex Albiziae 14-16 part, Rhizoma Acori Graminei 2-4 part, Herba Agrimoniae 14-16 part, PINGDIMU 14-16 part, Rhizoma Polygonati Odorati 14-16 part, boy's Herba Leonuri 14-16 part, Herba Bidentis Bipinnatae 14-16 part.
Described mixture is processed by following bulk drugs: 15 parts of Caulis Polygoni Multiflori, 15 parts of Cortex Albiziaes, 3 parts of Rhizoma Acori Graminei, 15 parts of Herba Agrimoniaes, 15 parts of PINGDIMU, 15 parts of Rhizoma Polygonati Odorati, 15 parts of boy's Herba Leonuris, 15 parts of Herba Bidentis Bipinnatae.
Described mixture also comprises sucrose 33-37 part, ethyl hydroxybenzoate 0.03-0.07 part.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is: the application of described mixture in the forgetful disease medicament of preparation treatment neurasthenia, insomnia and dreamful sleep, anxiety.
The invention has the advantages that: treat neurasthenic mixture, its compatibility meets Chinese medicine " monarch " principle, through pharmacodynamic experiment checking, the effect of have the blood that nourishes heart significantly, tranquilizing mind, fall fidgets due to deficiency, resolving depression being had one's ideas straightened out.It is forgetful to be mainly used in neurasthenia, insomnia and dreamful sleep, anxiety.Do not see obvious adverse reaction is arranged.Toxic and side effects is little, has less flavour of a drug number and curative effect preferably, be suitable for taking for a long time, and be a kind of mixture of treating neurasthenia safely and effectively.
The specific embodiment
Below in conjunction with form the specific embodiment provided by the invention is elaborated.
Embodiment 1
A kind of preparation () of treating neurasthenic mixture
Caulis Polygoni Multiflori 130 grams, Cortex Albiziae 130 grams, Rhizoma Acori Graminei 10 grams, Herba Agrimoniae 130 grams, PINGDIMU 130 grams, Rhizoma Polygonati Odorati 130 grams, boy's Herba Leonuri 130 grams, the Herba Bidentis Bipinnatae 130 gram prepared slices of Chinese crude drugs, the decocte with water secondary adds 5 times of water gagings for the first time and boils; Kept 60 minutes after boiling, medicine juice is crossed 120 mesh sieves, adds 3 times of water gagings for the second time and boils; Kept 45 minutes after boiling, medicine juice is crossed 120 mesh sieves, merges the secondary medicine juice; Be concentrated into 2000ml, leave standstill.Get supernatant and cross 120 mesh sieves, be concentrated into 1000ml.Get sucrose 330 grams with boiling water 180ml heating for dissolving, cross 120 mesh sieves, add in the medicinal liquid, continue to be concentrated into 1000ml; Taking ethylparaben 0.3 gram with an amount of 95% dissolve with ethanol, adds in the medicinal liquid, stirs, boil, and hot filling, sterilization promptly gets.
Embodiment 2
A kind of preparation (two) of treating neurasthenic mixture
Caulis Polygoni Multiflori 170 grams, Cortex Albiziae 170 grams, Rhizoma Acori Graminei 50 grams, Herba Agrimoniae 170 grams, PINGDIMU 170 grams, Rhizoma Polygonati Odorati 170 grams, boy's Herba Leonuri 170 grams, the Herba Bidentis Bipinnatae 170 gram prepared slices of Chinese crude drugs, the decocte with water secondary adds 5 times of water gagings for the first time and boils; Kept 60 minutes after boiling, medicine juice is crossed 120 mesh sieves, adds 3 times of water gagings for the second time and boils; Kept 45 minutes after boiling, medicine juice is crossed 120 mesh sieves, merges the secondary medicine juice; Be concentrated into 2000ml, leave standstill.Get supernatant and cross 120 mesh sieves, be concentrated into 1000ml.Get sucrose 370 grams with boiling water 180ml heating for dissolving, cross 120 mesh sieves, add in the medicinal liquid, continue to be concentrated into 1000ml; Taking ethylparaben 0.7 gram with an amount of 95% dissolve with ethanol, adds in the medicinal liquid, stirs, boil, and hot filling, sterilization promptly gets.
Embodiment 3
A kind of preparation (three) of treating neurasthenic mixture
Caulis Polygoni Multiflori 150 grams, Cortex Albiziae 150 grams, Rhizoma Acori Graminei 30 grams, Herba Agrimoniae 150 grams, PINGDIMU 150 grams, Rhizoma Polygonati Odorati 150 grams, boy's Herba Leonuri 150 grams, the Herba Bidentis Bipinnatae 150 gram prepared slices of Chinese crude drugs, the decocte with water secondary adds 5 times of water gagings for the first time and boils; Kept 60 minutes after boiling, medicine juice is crossed 120 mesh sieves, adds 3 times of water gagings for the second time and boils; Kept 45 minutes after boiling, medicine juice is crossed 120 mesh sieves, merges the secondary medicine juice; Be concentrated into 2000ml, leave standstill.Get supernatant and cross 120 mesh sieves, be concentrated into 1000ml.Get sucrose 350 grams with boiling water 180ml heating for dissolving, cross 120 mesh sieves, add in the medicinal liquid, continue to be concentrated into 1000ml; Taking ethylparaben 0.5 gram with an amount of 95% dissolve with ethanol, adds in the medicinal liquid, stirs, boil, and hot filling, sterilization promptly gets.
Embodiment 4
A kind of preparation (four) of treating neurasthenic mixture
Caulis Polygoni Multiflori 140 grams, Cortex Albiziae 140 grams, Rhizoma Acori Graminei 30 grams, Herba Agrimoniae 140 grams, PINGDIMU 140 grams, Rhizoma Polygonati Odorati 140 grams, boy's Herba Leonuri 140 grams, the Herba Bidentis Bipinnatae 140 gram prepared slices of Chinese crude drugs, the decocte with water secondary adds 5 times of water gagings for the first time and boils; Kept 60 minutes after boiling, medicine juice is crossed 120 mesh sieves, adds 3 times of water gagings for the second time and boils; Kept 45 minutes after boiling, medicine juice is crossed 120 mesh sieves, merges the secondary medicine juice; Be concentrated into 2000ml, leave standstill.Get supernatant and cross 120 mesh sieves, be concentrated into 1000ml.Get sucrose 350 grams with boiling water 180ml heating for dissolving, cross 120 mesh sieves, add in the medicinal liquid, continue to be concentrated into 1000ml; Taking ethylparaben 0.3 gram with an amount of 95% dissolve with ethanol, adds in the medicinal liquid, stirs, boil, and hot filling, sterilization promptly gets.
Embodiment 5
A kind of preparation (five) of treating neurasthenic mixture
Caulis Polygoni Multiflori 150 grams, Cortex Albiziae 140 grams, Rhizoma Acori Graminei 30 grams, Herba Agrimoniae 160 grams, PINGDIMU 150 grams, Rhizoma Polygonati Odorati 170 grams, boy's Herba Leonuri 140 grams, the Herba Bidentis Bipinnatae 160 gram prepared slices of Chinese crude drugs, the decocte with water secondary adds 5 times of water gagings for the first time and boils; Kept 60 minutes after boiling, medicine juice is crossed 120 mesh sieves, adds 3 times of water gagings for the second time and boils; Kept 45 minutes after boiling, medicine juice is crossed 120 mesh sieves, merges the secondary medicine juice; Be concentrated into 2000ml, leave standstill.Get supernatant and cross 120 mesh sieves, be concentrated into 1000ml.Get sucrose 370 grams with boiling water 180ml heating for dissolving, cross 120 mesh sieves, add in the medicinal liquid, continue to be concentrated into 1000ml; Taking ethylparaben 0.5 gram with an amount of 95% dissolve with ethanol, adds in the medicinal liquid, stirs, boil, and hot filling, sterilization promptly gets.
Embodiment 6
The preparation of No. 1 side of neurasthenia
Radix Ginseng 100 grams, Radix Angelicae Sinensis 150 grams, Poria 100 grams, Cortex Moutan 100 grams, Radix Ophiopogonis 100 grams, Radix Glycyrrhizae 50 grams, Rhizoma Acori Graminei 50 grams, Fructus Schisandrae Chinensis 50 grams, ripe Semen Ziziphi Spinosae 150 grams, Cortex Albiziae 100 grams, Caulis Polygoni Multiflori 50 grams; Manufacture method by Chinese medicine oral liquid; Add water dense fry in shallow oil to remove slag get 600 milliliters of liquid, packing is subsequent use.
Embodiment 7
The preparation of No. 2 sides of neurasthenia
Caulis Polygoni Multiflori 150 grams, Semen Ziziphi Spinosae 90 grams, Cortex Albiziae 60 grams, Radix Salviae Miltiorrhizae 90 grams, Fructus Schisandrae Chinensis 30 grams, by the conventional manufacture method of Chinese medicine decoction, decocte with water becomes the 500ml decoction, and packing is subsequent use.
Embodiment 8
The preparation of No. 3 sides of neurasthenia
Huai wheat 15 grams, Rhizoma Polygonati (processed) 10 grams, Rhizoma Chuanxiong 10 grams, Ramulus Uncariae Cum Uncis 10 grams, Bulbus Lilii 10 grams, QINGLONGCHI 9 grams, Os Draconis 11 grams, Radix Glycyrrhizae Preparata 6 grams, Radix Codonopsis 10 grams, 5 pieces in Fructus Jujubae, Caulis Polygoni Multiflori 10 grams, Cortex Albiziae 12 grams, Fructus Lycii 10 grams; By the conventional manufacture method of Chinese medicine decoction; Decocte with water becomes the 500ml decoction, and packing is subsequent use.
Embodiment 9
A kind of pharmacological evaluation of treating neurasthenic mixture
1. experiment material
Laboratory animal: Kunming kind white mice, body weight 20-23g, male and female half and half.
No. 1 side of neurasthenia: Radix Ginseng, Radix Angelicae Sinensis, Poria, Cortex Moutan, Radix Ophiopogonis, Radix Glycyrrhizae, Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, ripe Semen Ziziphi Spinosae, Cortex Albiziae, Caulis Polygoni Multiflori (mixture that adopts embodiment 6 to prepare);
No. 2 sides of neurasthenia: Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Albiziae, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis (mixture that adopts embodiment 7 to prepare);
No. 3 sides of neurasthenia: Huai wheat, Rhizoma Polygonati (processed), Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis, Bulbus Lilii, QINGLONGCHI, Os Draconis, Radix Glycyrrhizae Preparata, Radix Codonopsis, Fructus Jujubae, Caulis Polygoni Multiflori, Cortex Albiziae, Fructus Lycii (mixture that adopts embodiment 8 to prepare);
No. 4 sides of neurasthenia: Caulis Polygoni Multiflori, Cortex Albiziae, Rhizoma Acori Graminei, Herba Agrimoniae, PINGDIMU, Rhizoma Polygonati Odorati, boy's Herba Leonuri, Herba Bidentis Bipinnatae (mixture that adopts embodiment 3 to prepare).
Route of administration: gastric infusion (consistent) with the clinical application approach, successive administration 8 days, once a day, the administration volume is 0.3mL/10g.
2. experimental technique
(1) mixture is to the influence of mice spatial resolution and memory
Experimental technique: choose 50 of mices, be divided into 5 groups at random, 10 every group, establish matched group (normal saline); No. 1 side's group of neurasthenia (being called for short side's group No. 1), No. 2 side's groups of neurasthenia (being called for short side's group No. 2), No. 3 side's groups of neurasthenia (being called for short side's group No. 3); No. 4 side's groups of neurasthenia (being called for short side's group No. 4), gastric infusion, once a day; After administration on the 7th, carrying out Y labyrinth behavioral experiment in 1 hour, correctly serves as association's index to reach continuous quadratic, measures school grade; Test next day and be administered once again in preceding 1 hour, measure after the study test 24 hours memory achievement, and calculate and remember conservation rate.Experimental result: see table 1, table 1 is the influence of mixture to mice spatial resolution and memory.Visible by table 1 data; Compare with blank; No. 1 square group can significantly improve learning ability of mice (P＜0.05), No. 3 side's groups of No. 2 side combinations are not obvious with the raising effect of memory conservation rate to learning ability of mice, but No. 4 side's group highly significants improve learning ability of mice (P＜0.01); And can significantly improve mouse memory conservation rate (P＜0.05) simultaneously, this shows the square group of school grade and the memory that can improve mice No. 4.
Table 1 mixture is to the influence of mice spatial resolution and memory (X ± SD)
| Group | Number of animals (only) | School grade (inferior) | Memory conservation rate (%) |
| Matched group | 10 | 8.7±4.0 | 68.5±26.6 |
| No. 1 side's group | 10 | 5.1±4.50** | 60.5±13.3 |
| No. 2 side's groups | 10 | 6.4±3.10 | 68.6±41.0 |
| No. 3 side's groups | 10 | 8.6±2.92 | 53.4±51.0 |
| No. 4 side's groups | 10 | 3.6±3.10*** | 90.5±13.0** |
* P＜0.05 * * * P＜0.01 compares with blank
(2) mixture is to the influence of mice autonomic activities
Experimental technique: get 50 of mices, measure the spontaneous activity number of its 10min, reject defective mice; Be divided into 5 groups at random by movable number, 10 every group, establish matched group (normal saline); No. 1 side's group of neurasthenia (being called for short side's group No. 1); No. 2 side's groups of neurasthenia (being called for short side's group No. 2), No. 3 side's groups of neurasthenia (being called for short side's group No. 3), No. 4 side's groups of neurasthenia (being called for short side's group No. 4); Measure autonomic activities number in preceding each the treated animal 10min of administration, 1h measures autonomic activities number in the 10min once more behind gastric infusion.Experimental result is seen table 2, and table 2 is mixture influences to the mice autonomic activities.Visible by table 2 data; Compare with the blank group; No. 1 square group of autonomic activities (P＜0.05) that can significantly suppress mice, No. 3 side's groups of No. 2 side's combinations are not obvious to the inhibitory action of mice autonomic activities, and No. 4 side's groups have the inhibitory action (P＜0.01) of highly significant to the mice autonomic activities.
Table 2 mixture is to the influence of mice autonomic activities (X ± SD)
* P＜0.05 * * * P＜0.01 compares with blank
(3) mixture is to the influence of the length of one's sleep of pentobarbital sodium
Experimental technique: choose 50 of mices, be divided into 5 groups at random, 10 every group; If matched group (normal saline), No. 1 side's group of neurasthenia (being called for short side's group No. 1), No. 2 side's groups of neurasthenia (being called for short side's group No. 2); No. 3 side's groups of neurasthenia (being called for short side's group No. 3), No. 4 side's groups of neurasthenia (being called for short side's group No. 4), gastric infusion; Behind the 1h by lumbar injection pentobarbital sodium 40mg/kg; After giving pentobarbital sodium, as the animal sleep index, the length of one's sleep of mice respectively organized in record from righting reflex loss.Experimental result is seen table 3, and table 3 is mixture influences to the length of one's sleep of pentobarbital sodium.Visible by table 3 data; Compare with the blank group; No. 3 square group of lengths of one's sleep (P＜0.05) that can obviously prolong mice, No. 1 side group is not obvious to the prolongation effect of the length of one's sleep of mice with No. 2 side's groups, No. 4 square group can highly significant length of one's sleep (P＜0.01) of prolongation mice.
Table 3 mixture is to the influence of the length of one's sleep of pentobarbital sodium (X ± SD)
| Group | Number of animals (only) | The length of one's sleep (min) |
| Matched group | 10 | 40.4±19.8 |
| No. 1 side's group | 10 | 39.2±8.15 |
| No. 2 side's groups | 10 | 42.6±12.2 |
| No. 3 side's groups | 10 | 55.8±15.4** |
| No. 4 side's groups | 10 | 97.3±40.5*** |
* P＜0.05 * * * P＜0.01 compares with blank
(4) mixture is to the influence of mice hypoxia-bearing capability
Experimental technique: choose 50 of mices, be divided into 5 groups at random, 10 every group; If matched group (normal saline), No. 1 side's group of neurasthenia (being called for short side's group No. 1), No. 2 side's groups of neurasthenia (being called for short side's group No. 2); No. 3 side's groups of neurasthenia (being called for short side's group No. 3), No. 4 side's groups of neurasthenia (being called for short side's group No. 4), every group of gastric infusion; Behind the 40min mice is put into the airtight wide mouthed bottle of the 125mL that fills sodica calx respectively, the record mice time-to-live.Experimental result is seen table 4, and table 4 is mixture influences to the mice hypoxia-bearing capability.Visible by table 4 data; Compare with the blank group; No. 1 square group can significantly prolong the mice time-to-live (P＜0.05); No. 2 side group is not obvious to the prolongation effect of mice time-to-live with No. 3 side's groups, No. 4 square group can highly significant time-to-live (P＜0.01) of prolongation mice, it is thus clear that No. 4 Fang Zuneng significantly improve the hypoxia-bearing capability of mice.
Table 4 mixture is to the influence of mice hypoxia-bearing capability (X ± SD)
| Group | Number of animals (only) | Mean survival time (min) | Survival rate elongation (%) |
| Matched group | 10 | 18.31±3.12 | ? |
| No. 1 side's group | 10 | 22.74±3.81** | 24.2 |
| No. 2 side's groups | 10 | 20.66±3.26 | 12.8 |
| No. 3 side's groups | 10 | 19.74±3.81 | 7.8 |
| No. 4 side's groups | 10 | 27.66±3.26*** | 51.1 |
* P＜0.05 * * * P＜0.01 compares with blank
3. experiment conclusion
(1) No. 1 side's group of neurasthenia and No. 4 sides of the neurasthenia continuous gastric infusion of group can significantly improve the school grade (P＜0.05, P＜0.01) of mice in 7 days, and No. 4 side's group significantly improves mouse memory conservation rate (P＜0.05) simultaneously; 1h can significantly suppress the autonomic activities (P＜0.05, P＜0.01) of mice behind No. 1 side group and No. 4 side's group gastric infusions; No. 3 side's groups and No. 4 side's group gastric infusions can obviously prolong the length of one's sleep (P＜0.05, P＜0.01) of mice; No. 1 side's group and No. 4 side's group gastric infusions can prolong the hypoxia-bearing capability (P＜0.05, P＜0.01) of mice significantly.
In sum, No. 4 square group of school grade and memory that can significantly improve mice of neurasthenia, the autonomic activities of inhibition mice obviously prolongs the length of one's sleep and the hypoxia-bearing capability of mice.In 4 prescriptions Caulis Polygoni Multiflori and Cortex Albiziae are arranged all, point out this two flavors medicine in the treatment neurasthenia, to play an important role.
(2) No. 1 side in No. 4 sides of neurasthenia and neurasthenia compares the flavour of a drug number still less, better efficacy with No. 3 sides; No. 2 sides compare better efficacy with neurasthenia.
(3) No. 4 sides of neurasthenia have used better effect clinically.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; Can also make some improvement and replenish, these improvement and replenish and also should be regarded as protection scope of the present invention.
Claims (5)
1. treat neurasthenic mixture for one kind; It is characterized in that described mixture is processed by following bulk drugs: Caulis Polygoni Multiflori 13-17 part, Cortex Albiziae 13-17 part, Rhizoma Acori Graminei 1-5 part, Herba Agrimoniae 13-17 part, PINGDIMU 13-17 part, Rhizoma Polygonati Odorati 13-17 part, boy's Herba Leonuri 13-17 part, Herba Bidentis Bipinnatae 13-17 part.
2. mixture according to claim 1; It is characterized in that described mixture is processed by following bulk drugs: Caulis Polygoni Multiflori 14-16 part, Cortex Albiziae 14-16 part, Rhizoma Acori Graminei 2-4 part, Herba Agrimoniae 14-16 part, PINGDIMU 14-16 part, Rhizoma Polygonati Odorati 14-16 part, boy's Herba Leonuri 14-16 part, Herba Bidentis Bipinnatae 14-16 part.
3. mixture according to claim 2; It is characterized in that described mixture is processed by following bulk drugs: 15 parts of Caulis Polygoni Multiflori, 15 parts of Cortex Albiziaes, 3 parts of Rhizoma Acori Graminei, 15 parts of Herba Agrimoniaes, 15 parts of PINGDIMU, 15 parts of Rhizoma Polygonati Odorati, 15 parts of boy's Herba Leonuris, 15 parts of Herba Bidentis Bipinnatae.
4. mixture according to claim 3 is characterized in that, described mixture also comprises sucrose 33-37 part, ethyl hydroxybenzoate 0.03-0.07 part.
5. according to the arbitrary described mixture of claim 1-4, it is characterized in that the application of described mixture in preparation treatment neurasthenia, insomnia and dreamful sleep, forgetful disease medicament.
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| CN103191302A (en) * | 2013-04-11 | 2013-07-10 | 太仓市胜舟生物技术有限公司 | Use of seven medicinal herbs containing radix polygonati officinalis |
| CN103169879A (en) * | 2013-04-11 | 2013-06-26 | 太仓市胜舟生物技术有限公司 | Traditional Chinese medicine composition for treating tic disorder disease |
| CN103169873A (en) * | 2013-04-11 | 2013-06-26 | 太仓市胜舟生物技术有限公司 | Effective medicament for treating liver wind |
| CN103169874A (en) * | 2013-04-11 | 2013-06-26 | 太仓市胜舟生物技术有限公司 | Use of traditional Chinese medicine composition containing cortex albiziae |
| CN103169871A (en) * | 2013-04-11 | 2013-06-26 | 太仓市胜舟生物技术有限公司 | Medicament for treating tic disorder disease |
| CN103169878A (en) * | 2013-04-11 | 2013-06-26 | 太仓市胜舟生物技术有限公司 | Application of gastrodia elata in pharmacy |
| CN103169872A (en) * | 2013-04-11 | 2013-06-26 | 太仓市胜舟生物技术有限公司 | Application of traditional Chinese medicine composition |
| CN105327095A (en) * | 2015-10-29 | 2016-02-17 | 赵卫国 | Medicine for treating neurasthenia and preparing method thereof |
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| CN100546599C (en) * | 2007-05-29 | 2009-10-07 | 沈信堂 | The neurasthenic Chinese medicine of a kind of treatment |
| CN101129633B (en) * | 2007-09-19 | 2010-05-19 | 吉林省辉南天宇药业股份有限公司 | Medicine for neurasthenia and its preparation |
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