CN102008644B - Drug for treating neurasthenia and application thereof - Google Patents
Drug for treating neurasthenia and application thereof Download PDFInfo
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- CN102008644B CN102008644B CN2010105804523A CN201010580452A CN102008644B CN 102008644 B CN102008644 B CN 102008644B CN 2010105804523 A CN2010105804523 A CN 2010105804523A CN 201010580452 A CN201010580452 A CN 201010580452A CN 102008644 B CN102008644 B CN 102008644B
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Abstract
The invention relates to an application of a drug in the preparation of the drugs for treating diseases of neurasthenia, insomnia, dreaminess, anxiety and forgetfulness, and the drug is prepared from the following pharmaceutical raw materials in parts by weight: 18-22 parts of tuber fleeceflower stem, 18-22 parts of silktree albizzia bark, 3-7 parts of grassleaf sweelflag rhizome, 18-22 parts of hairyvein agrimonia herb and bud, 18-22 parts of Japanese ardisia herb, 18-22 parts of fragrant solomonseal rhizome, 18-22 parts of shoots of motherwort herb and 18-22 parts of bidens bipinnata. The compatibility of the drug is in line with the principle of monarch, minister, assistant and guide of traditional Chinese medicine, and the experimental verification of pharmacodynamics proves that the drug has the significant effects of nourishing heart blood, tranquilization, reducing dysphoria, resolving stagnation and inducing resuscitation. The drug has no obvious adverse reactions, a small number of medicines, better efficacy and low toxicity and side effects, and is applicable to long-term administration, thereby being the safe and effective drug for treating the neurasthenia.
Description
Technical field
The present invention relates to neurasthenic medicine of a kind of treatment and application thereof, specifically, is to be the Chinese medicine liquor of feedstock production with the Chinese herbal medicine.
Background technology
The neurasthenia is a kind of commonly encountered diseases, frequently-occurring disease; Mainly show as sleep disorder; Like " sleeping difficulty, early awakening, sleep unreal, lie awake all night " etc., weight person's giddy, headache, cardiopalmus, irritability, agitation, absent minded, hypomnesis and autonomic nervous dysfunction etc., the lighter influences work and study; Weight person loses interest in to surrounding, and world-weary thought is arranged.Epidemiological study should disease sickness rate in developed country, account for 20% of normal population, account for 10% of normal population at developing country's sickness rate.Data shows that work, study hypertonicity are acted hurriedly in a messy situation, and it is irregular to have a rest and sleep, and operating pressure is big, and health is in subhealth state, and feels to have burden and offending emotion etc., is to cause neurasthenic principal element.
The western medical treatment neurasthenia mainly relies on to stabilize and waits the tranquilizer symptomatic treatment of sleeping peacefully, but there is defective in these medicines aspect safety and the dependency, and side effect is bigger, forms addiction property, drug resistance easily, so should not take for a long time.
Chinese medicine thinks, diseases such as insomnia, forgetful, dizzy, spiritlessness and weakness, soreness of the waist and knees appear in neurastheniac, surely belong to " being insomnia " disease category.It is often can not obtain a kind of disease that ortho sleep is a characteristic.Be insomnia with the passing of time visceral dysfunction.Its concentrated reflection is on the heart, liver, spleen, lung, all dirty functional disorders of kidney.So the five internal organs are become estranged, the vital essence blood deficiency is its main etiology and pathogenesis, and is wherein close with heart kidney relation especially.Clinically, though the neurasthenia has the branch of deficiency and excess, see so that deficient syndrome more.The neurasthenia is normally with reinforce insufficiency and reduce excessiveness in the Chinese medicine treatment, regulating YIN and YANG, the calm principle that is of calming the nerves.Be used to treat neurasthenic Chinese patent medicine at present clinically Cinnabaris repose ball, nourishing blood to tranquillize the mind sheet, ZAOREN ANSHEN YE or the like are arranged.These medicines all have certain curative effect to the neurasthenia, but also have some problems, and slow like some drug effect, flavour of a drug are more, are not easy to preparation and use, and effect is not fairly obvious, and Time of Administration is long, and curative effect is unstable or the like.
Summary of the invention
The objective of the invention is to deficiency of the prior art; The application of a kind of medicine in the forgetful disease medicament of preparation treatment neurasthenia, insomnia and dreamful sleep, anxiety is provided, and described medicine is processed by following bulk drugs: Caulis Polygoni Multiflori 18-22 part, Cortex Albiziae 18-22 part, Rhizoma Acori Graminei 3-7 part, Herba Agrimoniae 18-22 part, PINGDIMU 18-22 part, Rhizoma Polygonati Odorati 18-22 part, boy's Herba Leonuri 18-22 part, Herba Bidentis Bipinnatae 18-22 part.
Described medicine is processed by following bulk drugs: Caulis Polygoni Multiflori 19-21 part, Cortex Albiziae 19-21 part, Rhizoma Acori Graminei 4-6 part, Herba Agrimoniae 19-21 part, PINGDIMU 19-21 part, Rhizoma Polygonati Odorati 19-21 part, boy's Herba Leonuri 19-21 part, Herba Bidentis Bipinnatae 19-21 part.
Described medicine is processed by following bulk drugs: 20 parts of Caulis Polygoni Multiflori, 20 parts in Herba Albiziae, 5 parts of Rhizoma Acori Graminei, 20 parts of Herba Agrimoniaes, 20 parts of PINGDIMU, 20 parts of Rhizoma Polygonati Odorati, 20 parts of boy's Herba Leonuris, 20 parts of Herba Bidentis Bipinnatae.
Described medicine also comprises cyclamate 0.3-0.7 part, simple syrup 8-12 part.
The neurasthenic medicine of a kind of treatment; It is characterized in that described medicine is processed by following bulk drugs: Caulis Polygoni Multiflori 18-22 part, Cortex Albiziae 18-22 part, Rhizoma Acori Graminei 3-7 part, Herba Agrimoniae 18-22 part, PINGDIMU 18-22 part, Rhizoma Polygonati Odorati 18-22 part, boy's Herba Leonuri 18-22 part, Herba Bidentis Bipinnatae 18-22 part.
Described medicine is processed by following bulk drugs: Caulis Polygoni Multiflori 19-21 part, Cortex Albiziae 19-21 part, Rhizoma Acori Graminei 4-6 part, Herba Agrimoniae 19-21 part, PINGDIMU 19-21 part, Rhizoma Polygonati Odorati 19-21 part, boy's Herba Leonuri 19-21 part, Herba Bidentis Bipinnatae 19-21 part.
Described medicine is processed by following bulk drugs: 20 parts of Caulis Polygoni Multiflori, 20 parts in Herba Albiziae, 5 parts of Rhizoma Acori Graminei, 20 parts of Herba Agrimoniaes, 20 parts of PINGDIMU, 20 parts of Rhizoma Polygonati Odorati, 20 parts of boy's Herba Leonuris, 20 parts of Herba Bidentis Bipinnatae.
Described medicine also comprises cyclamate 0.3-0.7 part, simple syrup 8-12 part.
The invention has the advantages that: the compatibility of this medicine meets Chinese medicine " monarch " principle, through pharmacodynamic experiment checking, the effect of have the blood that nourishes heart significantly, tranquilizing mind, fall fidgets due to deficiency, resolving depression being had one's ideas straightened out.Do not see obvious adverse reaction is arranged.The flavour of a drug number is less, and curative effect is better, and toxic and side effects is little, is suitable for taking for a long time, is a kind of medicine of treating neurasthenia safely and effectively.
The specific embodiment
Below in conjunction with form the specific embodiment provided by the invention is elaborated.
Embodiment 1
A kind of preparation () of treating neurasthenic medicine
80 milliliters of Caulis Polygoni Multiflori 180 grams, Cortex Albiziae 180 grams, Rhizoma Acori Graminei 30 grams, Herba Agrimoniae 180 grams, PINGDIMU 180 grams, Rhizoma Polygonati Odorati 180 grams, boy's Herba Leonuri 180 grams, Herba Bidentis Bipinnatae 180 grams, cyclamate 3 grams, simple syrup.
Get Rhizoma Acori Graminei 25 grams, add 10 times of water gagings, distillation extraction Aromatic water 75ml, subsequent use.
Distillation back medicinal residues are with all the other prepared slices of Chinese crude drugs, and water is carried secondary, adds 5 times of water gagings for the first time and boils, and the back of boiling kept 45 minutes, and medicine juice is crossed 120 mesh sieves; For the second time add 3 times of water gagings and boil, the back of boiling kept 30 minutes, and medicine juice is crossed 120 mesh sieves, merges medicinal liquid, is concentrated into 1100ml; Supernatant 1000ml is got in cooling, and precipitate with ethanol adds 95% ethanol 3000ml, and the limit edged stirs; Deposition is gone in cold preservation (under 4 ℃ of conditions), and decompression recycling ethanol is concentrated into 650ml, and other deposits.
Get the Rhizoma Acori Graminei Aromatic water, merge above-mentioned medicinal liquid, add simple syrup, cyclamate (dissolving with proper amount of boiling water) stirs, and adds water to 1000ml, filters with plate frame filter, and fill is sealed, and sterilization promptly gets.
Embodiment 2
A kind of preparation (two) of treating neurasthenic medicine
120 milliliters of Caulis Polygoni Multiflori 220 grams, Cortex Albiziae 220 grams, Rhizoma Acori Graminei 70 grams, Herba Agrimoniae 220 grams, PINGDIMU 220 grams, Rhizoma Polygonati Odorati 220 grams, boy's Herba Leonuri 220 grams, Herba Bidentis Bipinnatae 220 grams, cyclamate 7 grams, simple syrup.
Get Rhizoma Acori Graminei 25 grams, add 10 times of water gagings, distillation extraction Aromatic water 75ml, subsequent use.
Distillation back medicinal residues are with all the other prepared slices of Chinese crude drugs, and water is carried secondary, adds 5 times of water gagings for the first time and boils, and the back of boiling kept 45 minutes, and medicine juice is crossed 120 mesh sieves; For the second time add 3 times of water gagings and boil, the back of boiling kept 30 minutes, and medicine juice is crossed 120 mesh sieves, merges medicinal liquid, is concentrated into 1100ml; Supernatant 1000ml is got in cooling, and precipitate with ethanol adds 95% ethanol 3000ml, and the limit edged stirs; Deposition is gone in cold preservation (under 4 ℃ of conditions), and decompression recycling ethanol is concentrated into 650ml, and other deposits.
Get the Rhizoma Acori Graminei Aromatic water, merge above-mentioned medicinal liquid, add simple syrup, cyclamate (dissolving with proper amount of boiling water) stirs, and adds water to 1000ml, filters with plate frame filter, and fill is sealed, and sterilization promptly gets.
Embodiment 3
A kind of preparation (three) of treating neurasthenic medicine
100 milliliters of Caulis Polygoni Multiflori 200 grams, Cortex Albiziae 200 grams, Rhizoma Acori Graminei 50 grams, Herba Agrimoniae 200 grams, PINGDIMU 200 grams, Rhizoma Polygonati Odorati 200 grams, boy's Herba Leonuri 200 grams, Herba Bidentis Bipinnatae 200 grams, cyclamate 5 grams, simple syrup.
Get Rhizoma Acori Graminei 25 grams, add 10 times of water gagings, distillation extraction Aromatic water 75ml, subsequent use.
Distillation back medicinal residues are with all the other prepared slices of Chinese crude drugs, and water is carried secondary, adds 5 times of water gagings for the first time and boils, and the back of boiling kept 45 minutes, and medicine juice is crossed 120 mesh sieves; For the second time add 3 times of water gagings and boil, the back of boiling kept 30 minutes, and medicine juice is crossed 120 mesh sieves, merges medicinal liquid, is concentrated into 1100ml; Supernatant 1000ml is got in cooling, and precipitate with ethanol adds 95% ethanol 3000ml, and the limit edged stirs; Deposition is gone in cold preservation (under 4 ℃ of conditions), and decompression recycling ethanol is concentrated into 650ml, and other deposits.
Get the Rhizoma Acori Graminei Aromatic water, merge above-mentioned medicinal liquid, add simple syrup, cyclamate (dissolving with proper amount of boiling water) stirs, and adds water to 1000ml, filters with plate frame filter, and fill is sealed, and sterilization promptly gets.
Embodiment 4
A kind of preparation (four) of treating neurasthenic medicine
90 milliliters of Caulis Polygoni Multiflori 190 grams, Cortex Albiziae 190 grams, Rhizoma Acori Graminei 40 grams, Herba Agrimoniae 190 grams, PINGDIMU 190 grams, Rhizoma Polygonati Odorati 190 grams, boy's Herba Leonuri 190 grams, Herba Bidentis Bipinnatae 190 grams, cyclamate 4 grams, simple syrup.
Get Rhizoma Acori Graminei 25 grams, add 10 times of water gagings, distillation extraction Aromatic water 75ml, subsequent use.
Distillation back medicinal residues are with all the other prepared slices of Chinese crude drugs, and water is carried secondary, adds 5 times of water gagings for the first time and boils, and the back of boiling kept 45 minutes, and medicine juice is crossed 120 mesh sieves; For the second time add 3 times of water gagings and boil, the back of boiling kept 30 minutes, and medicine juice is crossed 120 mesh sieves, merges medicinal liquid, is concentrated into 1100ml; Supernatant 1000ml is got in cooling, and precipitate with ethanol adds 95% ethanol 3000ml, and the limit edged stirs; Deposition is gone in cold preservation (under 4 ℃ of conditions), and decompression recycling ethanol is concentrated into 650ml, and other deposits.
Get the Rhizoma Acori Graminei Aromatic water, merge above-mentioned medicinal liquid, add simple syrup, cyclamate (dissolving with proper amount of boiling water) stirs, and adds water to 1000ml, filters with plate frame filter, and fill is sealed, and sterilization promptly gets.
Embodiment 5
A kind of preparation (five) of treating neurasthenic medicine
110 milliliters of Caulis Polygoni Multiflori 210 grams, Cortex Albiziae 210 grams, Rhizoma Acori Graminei 60 grams, Herba Agrimoniae 210 grams, PINGDIMU 210 grams, Rhizoma Polygonati Odorati 210 grams, boy's Herba Leonuri 210 grams, Herba Bidentis Bipinnatae 210 grams, cyclamate 6 grams, simple syrup.
Get Rhizoma Acori Graminei 25 grams, add 10 times of water gagings, distillation extraction Aromatic water 75ml, subsequent use.
Distillation back medicinal residues are with all the other prepared slices of Chinese crude drugs, and water is carried secondary, adds 5 times of water gagings for the first time and boils, and the back of boiling kept 45 minutes, and medicine juice is crossed 120 mesh sieves; For the second time add 3 times of water gagings and boil, the back of boiling kept 30 minutes, and medicine juice is crossed 120 mesh sieves, merges medicinal liquid, is concentrated into 1100ml; Supernatant 1000ml is got in cooling, and precipitate with ethanol adds 95% ethanol 3000ml, and the limit edged stirs; Deposition is gone in cold preservation (under 4 ℃ of conditions), and decompression recycling ethanol is concentrated into 650ml, and other deposits.
Get the Rhizoma Acori Graminei Aromatic water, merge above-mentioned medicinal liquid, add simple syrup, cyclamate (dissolving with proper amount of boiling water) stirs, and adds water to 1000ml, filters with plate frame filter, and fill is sealed, and sterilization promptly gets.
Embodiment 6
The preparation of No. 1 side of neurasthenia
Radix Ginseng 100 grams, Radix Angelicae Sinensis 150 grams, Poria 100 grams, Cortex Moutan 100 grams, Radix Ophiopogonis 100 grams, Radix Glycyrrhizae 50 grams, Rhizoma Acori Graminei 50 grams, Fructus Schisandrae Chinensis 50 grams, ripe Semen Ziziphi Spinosae 150 grams, Cortex Albiziae 100 grams, Caulis Polygoni Multiflori 50 grams; Manufacture method by Chinese medicine oral liquid; Add water dense fry in shallow oil to remove slag get 600 milliliters of liquid, packing is subsequent use.
Embodiment 7
The preparation of No. 2 sides of neurasthenia
Caulis Polygoni Multiflori 150 grams, Semen Ziziphi Spinosae 90 grams, Cortex Albiziae 60 grams, Radix Salviae Miltiorrhizae 90 grams, Fructus Schisandrae Chinensis 30 grams, by the conventional manufacture method of Chinese medicine decoction, decocte with water becomes the 500ml decoction, and packing is subsequent use.
Embodiment 8
The preparation of No. 3 sides of neurasthenia
Huai wheat 15 grams, Rhizoma Polygonati (processed) 10 grams, Rhizoma Chuanxiong 10 grams, Ramulus Uncariae Cum Uncis 10 grams, Bulbus Lilii 10 grams, QINGLONGCHI 9 grams, Os Draconis 11 grams, Radix Glycyrrhizae Preparata 6 grams, Radix Codonopsis 10 grams, 5 pieces in Fructus Jujubae, Caulis Polygoni Multiflori 10 grams, Cortex Albiziae 12 grams, Fructus Lycii 10 grams; By the conventional manufacture method of Chinese medicine decoction; Decocte with water becomes the 500ml decoction, and packing is subsequent use.
Embodiment 9
A kind of pharmacological evaluation of treating neurasthenic medicine
1. experiment material
Laboratory animal: Kunming kind white mice, body weight 20-23g, male and female half and half.
No. 1 side of neurasthenia: Radix Ginseng, Radix Angelicae Sinensis, Poria, Cortex Moutan, Radix Ophiopogonis, Radix Glycyrrhizae, Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, ripe Semen Ziziphi Spinosae, Cortex Albiziae, Caulis Polygoni Multiflori (medicine that adopts embodiment 6 to prepare);
No. 2 sides of neurasthenia: Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Albiziae, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis (medicine that adopts embodiment 7 to prepare);
No. 3 sides of neurasthenia: Huai wheat, Rhizoma Polygonati (processed), Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis, Bulbus Lilii, QINGLONGCHI, Os Draconis, Radix Glycyrrhizae Preparata, Radix Codonopsis, Fructus Jujubae, Caulis Polygoni Multiflori, Cortex Albiziae, Fructus Lycii (medicine that adopts embodiment 8 to prepare);
No. 4 sides of neurasthenia: Caulis Polygoni Multiflori, Cortex Albiziae, Rhizoma Acori Graminei, Herba Agrimoniae, PINGDIMU, Rhizoma Polygonati Odorati, boy's Herba Leonuri, Herba Bidentis Bipinnatae (medicine that adopts embodiment 3 to prepare).
Route of administration: gastric infusion (consistent) with the clinical application approach, successive administration 8 days, once a day, the administration volume is 0.3mL/10g.
2. experimental technique
(1) medicine is to the influence of mice spatial resolution and memory
Experimental technique: choose 50 of mices, be divided into 5 groups at random, 10 every group, establish matched group (normal saline); No. 1 side's group of neurasthenia (being called for short side's group No. 1), No. 2 side's groups of neurasthenia (being called for short side's group No. 2), No. 3 side's groups of neurasthenia (being called for short side's group No. 3); No. 4 side's groups of neurasthenia (being called for short side's group No. 4), gastric infusion, once a day; After administration on the 7th, carrying out Y labyrinth behavioral experiment in 1 hour, correctly serves as association's index to reach continuous quadratic, measures school grade; Test next day and be administered once again in preceding 1 hour, measure after the study test 24 hours memory achievement, and calculate and remember conservation rate.Experimental result: see table 1, table 1 is the influence of medicine to mice spatial resolution and memory.Visible by table 1 data; Compare with blank; No. 1 square group can significantly improve learning ability of mice (P＜0.05), No. 3 side's groups of No. 2 side combinations are not obvious with the raising effect of memory conservation rate to learning ability of mice, but No. 4 side's group highly significants improve learning ability of mice (P＜0.01); And can significantly improve mouse memory conservation rate (P＜0.05) simultaneously, this shows the square group of school grade and the memory that can improve mice No. 4.
Table 1 medicine is to the influence of mice spatial resolution and memory (X ± SD)
| Group | Number of animals (only) | School grade (inferior) | Memory conservation rate (%) |
| Matched group | 10 | 8.7±4.0 | 68.5±26.6 |
| No. 1 side's group | 10 | 5.1±4.50** | 60.5±13.3 |
| No. 2 side's groups | 10 | 6.4±3.10 | 68.6±41.0 |
| No. 3 side's groups | 10 | 8.6±2.92 | 53.4±51.0 |
| No. 4 side's groups | 10 | 3.8±3.10*** | 89.6±13.0** |
* P＜0.05 * * * P＜0.01 compares with blank
(2) medicine is to the influence of mice autonomic activities
Experimental technique: get 50 of mices, measure the spontaneous activity number of its 10min, reject defective mice; Be divided into 5 groups at random by movable number, 10 every group, establish matched group (normal saline); No. 1 side's group of neurasthenia (being called for short side's group No. 1); No. 2 side's groups of neurasthenia (being called for short side's group No. 2), No. 3 side's groups of neurasthenia (being called for short side's group No. 3), No. 4 side's groups of neurasthenia (being called for short side's group No. 4); Measure autonomic activities number in preceding each the treated animal 10min of administration, 1h measures autonomic activities number in the 10min once more behind gastric infusion.Experimental result is seen table 2, and table 2 is medicine influences to the mice autonomic activities.Visible by table 2 data; Compare with the blank group; No. 1 square group of autonomic activities (P＜0.05) that can significantly suppress mice, No. 3 side's groups of No. 2 side's combinations are not obvious to the inhibitory action of mice autonomic activities, and No. 4 side's groups have the inhibitory action (P＜0.01) of highly significant to the mice autonomic activities.
Table 2 medicine is to the influence of mice autonomic activities (X ± SD)
* P＜0.05 * * * P＜0.01 compares with blank
(3) medicine is to the influence of the length of one's sleep of pentobarbital sodium
Experimental technique: choose 50 of mices, be divided into 5 groups at random, 10 every group; If matched group (normal saline), No. 1 side's group of neurasthenia (being called for short side's group No. 1), No. 2 side's groups of neurasthenia (being called for short side's group No. 2); No. 3 side's groups of neurasthenia (being called for short side's group No. 3), No. 4 side's groups of neurasthenia (being called for short side's group No. 4), gastric infusion; Behind the 1h by lumbar injection pentobarbital sodium 40mg/kg; After giving pentobarbital sodium, as the animal sleep index, the length of one's sleep of mice respectively organized in record from righting reflex loss.Experimental result is seen table 3, and table 3 is medicine influences to the length of one's sleep of pentobarbital sodium.Visible by table 3 data; Compare with the blank group; No. 3 square group of lengths of one's sleep (P＜0.05) that can obviously prolong mice, No. 1 side group is not obvious to the prolongation effect of the length of one's sleep of mice with No. 2 side's groups, No. 4 square group can highly significant length of one's sleep (P＜0.01) of prolongation mice.
Table 3 medicine is to the influence of the length of one's sleep of pentobarbital sodium (X ± SD)
| Group | Number of animals (only) | The length of one's sleep (min) |
| Matched group | 10 | 40.4±19.8 |
| No. 1 side's group | 10 | 39.2±8.15 |
| No. 2 side's groups | 10 | 42.6±12.2 |
| No. 3 side's groups | 10 | 55.8±15.4** |
| No. 4 side's groups | 10 | 89.3±30.5*** |
* P＜0.05 * * * P＜0.01 compares with blank
(4) medicine is to the influence of mice hypoxia-bearing capability
Experimental technique: choose 50 of mices, be divided into 5 groups at random, 10 every group; If matched group (normal saline), No. 1 side's group of neurasthenia (being called for short side's group No. 1), No. 2 side's groups of neurasthenia (being called for short side's group No. 2); No. 3 side's groups of neurasthenia (being called for short side's group No. 3), No. 4 side's groups of neurasthenia (being called for short side's group No. 4), every group of gastric infusion; Behind the 40min mice is put into the airtight wide mouthed bottle of the 125mL that fills sodica calx respectively, the record mice time-to-live.Experimental result is seen table 4, and table 4 is medicine influences to the mice hypoxia-bearing capability.Visible by table 4 data; Compare with the blank group; No. 1 square group can significantly prolong the mice time-to-live (P＜0.05); No. 2 side group is not obvious to the prolongation effect of mice time-to-live with No. 3 side's groups, No. 4 square group can highly significant time-to-live (P＜0.01) of prolongation mice, it is thus clear that No. 4 Fang Zuneng significantly improve the hypoxia-bearing capability of mice.
Table 4 medicine is to the influence of mice hypoxia-bearing capability (X ± SD)
| Group | Number of animals (only) | Mean survival time (min) | Survival rate elongation (%) |
| Matched group | 10 | 18.31±3.12 | ? |
| No. 1 side's group | 10 | 22.74±3.81** | 24.2 |
| No. 2 side's groups | 10 | 20.66±3.26 | 12.8 |
| No. 3 side's groups | 10 | 19.74±3.81 | 7.8 |
| No. 4 side's groups | 10 | 26.52±3.26*** | 44.8 |
* P＜0.05 * * * P＜0.01 compares with blank
3. experiment conclusion
(1) No. 1 side's group of neurasthenia and No. 4 sides of the neurasthenia continuous gastric infusion of group can significantly improve the school grade (P＜0.05, P＜0.01) of mice in 7 days, and No. 4 side's group significantly improves mouse memory conservation rate (P＜0.05) simultaneously; 1h can significantly suppress the autonomic activities (P＜0.05, P＜0.01) of mice behind No. 1 side group and No. 4 side's group gastric infusions; No. 3 side's groups and No. 4 side's group gastric infusions can obviously prolong the length of one's sleep (P＜0.05, P＜0.01) of mice; No. 1 side's group and No. 4 side's group gastric infusions can prolong the hypoxia-bearing capability (P＜0.05, P＜0.01) of mice significantly.
In sum, No. 4 square group of school grade and memory that can significantly improve mice of neurasthenia, the autonomic activities of inhibition mice obviously prolongs the length of one's sleep and the hypoxia-bearing capability of mice.Caulis Polygoni Multiflori and Cortex Albiziae two flavor medicines are all arranged in 4 prescriptions, point out this two flavors medicine in the treatment neurasthenia, to play an important role.
(2) No. 1 side in No. 4 sides of neurasthenia and neurasthenia compares the flavour of a drug number still less, better efficacy with No. 3 sides; No. 2 sides compare better efficacy with neurasthenia.
(3) No. 4 sides of neurasthenia have used better effect clinically.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; Can also make some improvement and replenish, these improvement and replenish and also should be regarded as protection scope of the present invention.
Claims (8)
1. the medicine application in the forgetful disease medicament of preparation treatment neurasthenia, insomnia and dreamful sleep, anxiety, described medicine is processed by following bulk drugs: Caulis Polygoni Multiflori 18-22 part, Cortex Albiziae 18-22 part, Rhizoma Acori Graminei 3-7 part, Herba Agrimoniae 18-22 part, PINGDIMU 18-22 part, Rhizoma Polygonati Odorati 18-22 part, boy's Herba Leonuri 18-22 part, Herba Bidentis Bipinnatae 18-22 part.
2. application according to claim 1; It is characterized in that described medicine is processed by following bulk drugs: Caulis Polygoni Multiflori 19-21 part, Cortex Albiziae 19-21 part, Rhizoma Acori Graminei 4-6 part, Herba Agrimoniae 19-21 part, PINGDIMU 19-21 part, Rhizoma Polygonati Odorati 19-21 part, boy's Herba Leonuri 19-21 part, Herba Bidentis Bipinnatae 19-21 part.
3. application according to claim 2; It is characterized in that described medicine is processed by following bulk drugs: 20 parts of Caulis Polygoni Multiflori, 20 parts in Herba Albiziae, 5 parts of Rhizoma Acori Graminei, 20 parts of Herba Agrimoniaes, 20 parts of PINGDIMU, 20 parts of Rhizoma Polygonati Odorati, 20 parts of boy's Herba Leonuris, 20 parts of Herba Bidentis Bipinnatae.
4. application according to claim 3 is characterized in that, described medicine also comprises cyclamate 0.3-0.7 part, simple syrup 8-12 part.
5. treat neurasthenic medicine for one kind; It is characterized in that described medicine is processed by following bulk drugs: Caulis Polygoni Multiflori 18-22 part, Cortex Albiziae 18-22 part, Rhizoma Acori Graminei 3-7 part, Herba Agrimoniae 18-22 part, PINGDIMU 18-22 part, Rhizoma Polygonati Odorati 18-22 part, boy's Herba Leonuri 18-22 part, Herba Bidentis Bipinnatae 18-22 part.
6. medicine according to claim 5; It is characterized in that described medicine is processed by following bulk drugs: Caulis Polygoni Multiflori 19-21 part, Cortex Albiziae 19-21 part, Rhizoma Acori Graminei 4-6 part, Herba Agrimoniae 19-21 part, PINGDIMU 19-21 part, Rhizoma Polygonati Odorati 19-21 part, boy's Herba Leonuri 19-21 part, Herba Bidentis Bipinnatae 19-21 part.
7. medicine according to claim 6; It is characterized in that described medicine is processed by following bulk drugs: 20 parts of Caulis Polygoni Multiflori, 20 parts in Herba Albiziae, 5 parts of Rhizoma Acori Graminei, 20 parts of Herba Agrimoniaes, 20 parts of PINGDIMU, 20 parts of Rhizoma Polygonati Odorati, 20 parts of boy's Herba Leonuris, 20 parts of Herba Bidentis Bipinnatae.
8. medicine according to claim 7 is characterized in that, described medicine also comprises cyclamate 0.3-0.7 part, simple syrup 8-12 part.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105804523A CN102008644B (en) | 2010-12-09 | 2010-12-09 | Drug for treating neurasthenia and application thereof |
Applications Claiming Priority (1)
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| CN101401906A (en) * | 2008-10-23 | 2009-04-08 | 宋兆普 | Anshen oral liquid for treating aypnia |
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