CN103860827B

CN103860827B - One treats migrainous Chinese medicine preparation

Info

Publication number: CN103860827B
Application number: CN201410112341.8A
Authority: CN
Inventors: 苏秀峰; 李娜
Original assignee: Individual
Current assignee: Su Xiufeng
Priority date: 2014-03-14
Filing date: 2014-03-14
Publication date: 2016-08-17
Anticipated expiration: 2034-03-14
Also published as: CN103860827A

Abstract

The invention discloses one and treat migrainous Chinese medicine preparation.Modern medicine is thought, migraine is that intracranial vessel is releived dysfunction, blood obstacle, involves pain sensation fiber nerve and the severe headache that causes, belong to motherland's medical science " have a headache ", the category such as " migraine ".To this end, the present invention selects Chinese medicine dysosma auranticocaulis (Hand. Mazz.) Hu, Rhizoma Tupistrae Chinensis, Flos Caraganae intermediae, Herba Agrimoniae, Radix seu Caulis Kadsurae Heteroclitae, Fructus Citri, Herba Swertiae heteranthae, Radix violae delavayi, Caulis Polygoni Multiflori, Herba Salviae Cavaleriei, Radix Glycyrrhizae 5.Being made decoction by I institute Drug Manufacturing Room, through clinical trial, be 73.8%% to migrainous obvious effective rate, total effective rate is 96.2%, and toxic and side effects is little.

Description

One treats migrainous Chinese medicine preparation

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to one and treat migrainous Chinese medicine Preparation.

Background technology

Migraine is one of common clinical disease, is the common sympton of department of neurology, and the cause of disease is a lot, Disease outside including intracranial, cranium, all over the body etc. tens kinds.Migraine is the one of vascular headache, Primary disease is the syndrome caused by the outer tremulous pulse systolic and diastolic function disorder of intracranial, and sickness rate is higher, It is about 5%.Age of onset was at 14 years old-48 years old, and female is the maleest.Ache with side frontal temporal part Pain is its feature, aggravates based on jumping pain, severe pain or paroxysmal；Often break out, typically Continue 4h-72h, rarely exceed 72 hours；Mostly being unilateral headache, bilateral headache occurs Rate is relatively low, accounts for 25%～60%；Its morbidity and inherited genetic factors, Nervous and Mental Factors, endocrine The factor such as factor and diet is relevant, and risk factor mostly is nervous, worried, tired, flu or Wound.Finding through clinical experience in recent years, Chinese medicine has relatively in terms for the treatment of migraine Good curative effect.

Summary of the invention

It is an object of the invention to provide one and treat migrainous Chinese medicine preparation.Modern medicine is recognized It is that intracranial vessel is releived dysfunction for, migraine, blood obstacle, involves pain sensation fiber god Through and the severe headache that causes.Belong to motherland medical science " have a headache ", the category such as " migraine ".

It is an object of the invention to be achieved through the following technical solutions, during this treatment is migrainous Medicine preparation is made up of the Chinese medicine of following weight portion: dysosma auranticocaulis (Hand. Mazz.) Hu 15 20 parts, Rhizoma Tupistrae Chinensis 10 15 parts, Flos Caraganae intermediae 16 22 parts, Herba Agrimoniae 20 25 parts, Radix seu Caulis Kadsurae Heteroclitae 9 17 parts, fragrant Rafter 58 parts, Herba Swertiae heteranthae 13 18 parts, Radix violae delavayi 48 parts, Caulis Polygoni Multiflori 15 25 parts, Herba Salviae Cavaleriei 25 30 parts, 46 parts of Radix Glycyrrhizae.

Preferably, dysosma auranticocaulis (Hand. Mazz.) Hu 18 parts, Rhizoma Tupistrae Chinensis 13 parts, Flos Caraganae intermediae 19 parts, red crowned crane Grass 23 parts, Radix seu Caulis Kadsurae Heteroclitae 13 parts, Fructus Citri 6.5 parts, Herba Swertiae heteranthae 16 parts, Radix violae delavayi 6 parts, Caulis Polygoni Multiflori 20 parts, Herba Salviae Cavaleriei 27 parts, 5 parts of Radix Glycyrrhizae.

Above-mentioned Chinese medicine decocting is made decoction by traditional method by preparation method.

Fang Zhong: dysosma auranticocaulis (Hand. Mazz.) Hu, Rhizoma Tupistrae Chinensis, Flos Caraganae intermediae, Herba Agrimoniae eliminating stagnation are invigorated blood circulation, detumescence Pain relieving, heat clearing away of detoxifying, nourishing yin and purging fire, nourishing blood to tranquillize the mind；Radix seu Caulis Kadsurae Heteroclitae: expelling wind and removing dampness, circulation of qi promoting Invigorate blood circulation；Fructus Citri, Herba Swertiae heteranthae dispersing the stagnated live-QI to relieve the stagnation of QI regulating the flow of QI to ease the stomach, suppressing the hyperactive liver to relieve the wind syndrome, heart tonifying nourishes blood；Yellow Flower common violet, Caulis Polygoni Multiflori removing obstruction in the collateral to relieve pain, tranquilizing by nourishing the heart；Herba Salviae Cavaleriei: hemostasis removing heat from blood；Radix Glycyrrhizae benefit Gas invigorating middle warmer heat-clearing and toxic substances removing, alleviates pain relieving, the mediation property of medicine.

Clinical data

1, physical data 130 example all for being diagnosed as the patient of " migraine " by my Out-patient Department, The maleest 55 examples, female 75 example；Age of onset 20～75 years old；The shortest person of the course of disease 2 days, Elder 20 years.All cases is the most all arranged through cerebral CT or cranium brain magnetic resonance imaging inspection Have a headache caused by organic disease, and do " rheoencephalogram " the most afterwards and " through cranium coloured silk Color Doppler " check to observe curative effect.Inducement person 29 relevant with menstrual cycle example, tired mistake Degree person 50 example, feelings will impassable patient 36 example, without obvious inducement person 15 example.

2, the headache of diagnostic criteria repeated relapsing, the intermission is completely normal, gets rid of other The headache that organic disease causes；Possess 3 in following 6 the most diagnosable: 1. have a headache With Nausea and vomiting during outbreak, time or have ictal stomachache；2. side headache partially；3. beat Property headache；4. short-term is had a rest or alleviates after sleep；5. visual abnormality；6. there is migrainous family Race's history.

3 Therapeutic Method this group patients take Chinese medicine preparation of the present invention, weigh many Flower Radix et Rhizoma Dysosmatis 18g, Rhizoma Tupistrae Chinensis 13g, Flos Caraganae intermediae 19 parts, Herba Agrimoniae 23g, Radix seu Caulis Kadsurae Heteroclitae 13g, Fructus Citri 6.5g, Herba Swertiae heteranthae 16g, Radix violae delavayi 6g, Caulis Polygoni Multiflori 20g, Herba Salviae Cavaleriei 27g, sweet Grass 5g, makes decoction by traditional method decocting, every day 1 dose, early, 2 sub-services in evening, It within 7 days, it is a course for the treatment of.

4, efficacy assessment standard: the curative effect after (1) treatment.Effective: transference cure, brain blood Flow graph, cranium brain color Doppler inspection recover normal, follow up a case by regular visits to 2 years not recur；Effective: disease Shape disappears, and rheoencephalogram, cranium brain color Doppler inspection still have exception, in following up a case by regular visits to 2 years still Having outbreak, attack times reduces 2/3, and the symptom of outbreak the most substantially alleviates；Invalid: symptom Though having alleviated, attack times does not subtracts, and rheoencephalogram, cranium brain color Doppler inspection are without changing Kind.

5, therapeutic outcome (1) this group patient treatment adds up curative effect after 3 courses for the treatment of, wherein Effective: 96 examples (73.8%)；Effective: 29 examples (22.3%)；Invalid: 5 examples (3.8%)； Total effective rate reaches 96.2%.

(2) cerebral blood flow Indexes Comparison before and after treatment.Move before middle cerebral artery (MCA), brain Significantly reduction is all had after the treatment of arteries and veins (ACA) flow velocity.See table 1.

Cerebral blood flow Indexes Comparison (cm/s, x ± s) before and after table 1. treatment

5, model case Lee so-and-so, female, 30 years old, office worker.June calendar year 2001 First visit on the 20th.Migraine 7 years, through integrative therapy poor effect for many years.Recently headache is sent out Make frequently, weekly outbreak 2～4 times, and have sleep poor, vexed, irritability, have concurrently hypochondriac pain, Bitter taste, flushing, red tongue, yellow and thin fur, stringy pulse, inappetence, it is diagnosed as migraine.Clothes Use Chinese medicine preparation of the present invention, 7 doses.15 days 2 January in 2010 examines, and patient has a headache Alleviate, sleep improvement.Appetite increases, and examines its light red tongue, white and thin fur, moderate pulse slightly string.Continue Take 3 doses.10 days 3 February in 2010 examines, and patient states headache heals, and other simultaneous phenomenon disappears Lose, follow up a case by regular visits to 2 years, recur the most again.

Detailed description of the invention

Embodiment one: weigh dysosma auranticocaulis (Hand. Mazz.) Hu 18g, Rhizoma Tupistrae Chinensis 13g, Flos Caraganae intermediae 19 parts, Herba Agrimoniae 23g, Radix seu Caulis Kadsurae Heteroclitae 13g, Fructus Citri 6.5g, Herba Swertiae heteranthae 16g, Radix violae delavayi 6g, night Hand over rattan 20g, Herba Salviae Cavaleriei 27g, Radix Glycyrrhizae 5g, become decoction by traditional preparation methods decocting.

Embodiment two: weigh dysosma auranticocaulis (Hand. Mazz.) Hu 20g, Rhizoma Tupistrae Chinensis 15g, Flos Caraganae intermediae 22 parts, Herba Agrimoniae 25g, Radix seu Caulis Kadsurae Heteroclitae 17g, Fructus Citri 8g, Herba Swertiae heteranthae 13g, Radix violae delavayi 8g, Polygonm multiflorum Thunb Rattan 25g, Herba Salviae Cavaleriei 30g, Radix Glycyrrhizae 6g, become decoction by traditional preparation methods decocting.

Embodiment three: weigh dysosma auranticocaulis (Hand. Mazz.) Hu 15g, Rhizoma Tupistrae Chinensis 10g, Flos Caraganae intermediae 16 parts, Herba Agrimoniae 20g, Radix seu Caulis Kadsurae Heteroclitae 9g, Fructus Citri 5g, Herba Swertiae heteranthae 18g, Radix violae delavayi 4g, Polygonm multiflorum Thunb Rattan 15g, Herba Salviae Cavaleriei 25g, Radix Glycyrrhizae 4g, become decoction by traditional preparation methods decocting.

Claims

1. treat migrainous Chinese medicine preparation for one kind, it is characterised in that this Chinese medicine preparation is by lower heavy The Chinese medicine of amount part is made: dysosma auranticocaulis (Hand. Mazz.) Hu 15-20 part, Rhizoma Tupistrae Chinensis 10-15 part, Flos Caraganae intermediae 16-22 part, Herba Agrimoniae 20-25 part, Radix seu Caulis Kadsurae Heteroclitae 9-17 part, Fructus Citri 5-8 part, Herba Swertiae heteranthae 13-18 part, Radix violae delavayi 4-8 part, Caulis Polygoni Multiflori 15-25 part, Herba Salviae Cavaleriei 25-30 part, sweet Grass 4-6 part.

One the most according to claim 1 treats migrainous Chinese medicine preparation, its feature It is that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: dysosma auranticocaulis (Hand. Mazz.) Hu 18 parts, bamboo root 7 13 parts, Flos Caraganae intermediae 19 parts, Herba Agrimoniae 23 parts, Radix seu Caulis Kadsurae Heteroclitae 13 parts, Fructus Citri 6.5 parts, Herba Swertiae heteranthae 16 parts, Radix violae delavayi 6 parts, Caulis Polygoni Multiflori 20 parts, Herba Salviae Cavaleriei 27 parts, Radix Glycyrrhizae 5 Part.