CN105853528A - Wild jujube extract for treating cold - Google Patents
Wild jujube extract for treating cold Download PDFInfo
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- CN105853528A CN105853528A CN201610385969.4A CN201610385969A CN105853528A CN 105853528 A CN105853528 A CN 105853528A CN 201610385969 A CN201610385969 A CN 201610385969A CN 105853528 A CN105853528 A CN 105853528A
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- wild jujube
- extract
- jujube extract
- thick paste
- flu
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- 240000008866 Ziziphus nummularia Species 0.000 title claims abstract description 49
- 239000000843 powder Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000006228 supernatant Substances 0.000 claims abstract description 8
- 229930013930 alkaloid Natural products 0.000 claims abstract description 4
- 239000012153 distilled water Substances 0.000 claims abstract description 4
- 238000000605 extraction Methods 0.000 claims abstract description 4
- 150000004676 glycans Chemical class 0.000 claims abstract description 4
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 4
- 239000005017 polysaccharide Substances 0.000 claims abstract description 4
- 238000010992 reflux Methods 0.000 claims abstract description 4
- 150000003648 triterpenes Chemical class 0.000 claims abstract description 4
- 206010022000 influenza Diseases 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 13
- 239000002775 capsule Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000002002 slurry Substances 0.000 claims description 6
- RHAXKFFKGZJUOE-UHFFFAOYSA-N 7-acetyl-6-ethyl-3,5,8-trihydroxy-9,10-dioxoanthracene-1,2-dicarboxylic acid Chemical compound O=C1C2=CC(O)=C(C(O)=O)C(C(O)=O)=C2C(=O)C2=C1C(O)=C(CC)C(C(C)=O)=C2O RHAXKFFKGZJUOE-UHFFFAOYSA-N 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 3
- 150000003797 alkaloid derivatives Chemical class 0.000 claims description 3
- 206010037660 Pyrexia Diseases 0.000 abstract description 5
- 206010011224 Cough Diseases 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 238000001291 vacuum drying Methods 0.000 abstract description 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 2
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 abstract 1
- 230000002155 anti-virotic effect Effects 0.000 abstract 1
- 238000000227 grinding Methods 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 230000036760 body temperature Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000004356 Hysteria Diseases 0.000 description 1
- 230000001539 anorectic effect Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 208000012839 conversion disease Diseases 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000015096 spirit Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of medicine and particularly relates to a wild jujube extract for treating cold. The extract is prepared by the following steps: removing pits of wild jujubes, grinding the wild jujubes into pulp, adding distilled water of which the volume is 2 times of that of the pulp for carrying out microwave extraction, carrying out standing, taking supernatant liquor, retaining residues, concentrating the supernatant liquor into thick paste by a rotary evaporator, carrying out vacuum drying on the thick paste, and smashing the dried thick paste to obtain powder A; adding 70% ethanol of which the volume is 8 times of that of the residues into the residues, carrying out reflux extraction at 80 DEG C for 2 hours, concentrating the extract into the thick paste by the rotary evaporator until the water content of the thick paste is 8%, carrying out vacuum drying on the thick paste, and smashing the dried thick paste to obtain powder B; and mixing the powder A and the powder B to obtain the wild jujube extract for treating cold. The wild jujube extract for treating cold contains 138mg/g of wild jujube polysaccharide, 0.16mg/g of cyclic adenosine monophosphate, 0.19mg/g of triterpenes and 0.12mg/g of alkaloids. The wild jujube extract for treating cold has obvious anti-inflammatory, fever-reducing, cough-relieving and anti-virus effects, is safe in medication, and is free of toxic or side effect.
Description
Technical field
The present invention relates to pharmaceutical technology field, be specifically related to a kind of wild jujube extract treating flu.
Background technology
The nutritive value of wild jujube is the highest, as the application in TCM history of existing more than 2000 year, it is mainly used in the treatment of the card such as the deficiency of qi in middle-jiao, weakness of the spleen and the stomach, fatigue and asthenia, anorexia and loose stool, the deficiency of blood are sallow, women's hysteria, there is the effects such as qi-restoratives benefit gas, nourishing blood and tranquilization, strengthening the spleen and stomach, it it is the good health nutrient of the patients such as weakness of the spleen and the stomach, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep, from clinical practice, wild jujube extract has preferable therapeutic efficiency to insomnia and dreamful sleep, there are no at present with the report in terms of its extract for treating flu.
Summary of the invention
It is an object of the invention to provide a kind of wild jujube extract treating flu.
A kind of wild jujube extract treating flu, prepares by the following method:
Slurries are worn in fresh wild jujube stoning, the distilled water adding slurry volume 2 times processes 58 minutes under the microwave that power is 22W, standing takes supernatant liquid, retain residue, being 0.098mpa by supernatant liquid in vacuum, the speed of rotation is 100rpm, and temperature is to be concentrated into, under the Rotary Evaporators of 80-85 DEG C, the thick paste that water content is 8%, thick paste is vacuum dried, is ground into powder thing A；
In residue, add the ethanol of residue volume 8 times 70%, refluxing extraction 2 hours at 80 DEG C, be 0.098mpa by extract in vacuum, the speed of rotation is 100rpm, temperature is to be concentrated into, under the Rotary Evaporators of 65-70 DEG C, the thick paste that water content is 8%, is vacuum dried by thick paste, is ground into powder thing B；
Powder thing A and powder thing B is mixed to get the wild jujube extract for the treatment of flu.
Containing wild jujube polysaccharide 138mg/g, CAMP 0.16mg/g, triterpenes 0.19mg/g, alkaloid 0.12mg/g in the wild jujube extract of described treatment flu.
The wild jujube extract of described treatment flu is used for being prepared as tablet, granule, oral liquid, capsule as sole active ingredient, wherein, every tablet is containing described wild jujube extract 0.2g, often bag granule contains described wild jujube extract 0.2g, containing described wild jujube extract 0.2g in every 15ml oral liquid, containing described wild jujube extract 0.2g in every seed lac capsule.
The present invention treats the wild jujube extract anti-inflammatory of flu, cooling, cough-relieving, antiviral effect substantially, and drug safety has no side effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be described,
Embodiment 1,
A kind of wild jujube extract treating flu, prepares by the following method:
Slurries are worn in fresh wild jujube stoning, the distilled water adding slurry volume 2 times processes 58 minutes under the microwave that power is 22W, standing takes supernatant liquid, retain residue, being 0.098mpa by supernatant liquid in vacuum, the speed of rotation is 100rpm, and temperature is to be concentrated into, under the Rotary Evaporators of 80-85 DEG C, the thick paste that water content is 8%, thick paste is vacuum dried, is ground into powder thing A；
In residue, add the ethanol of residue volume 8 times 70%, refluxing extraction 2 hours at 80 DEG C, be 0.098mpa by extract in vacuum, the speed of rotation is 100rpm, temperature is to be concentrated into, under the Rotary Evaporators of 65-70 DEG C, the thick paste that water content is 8%, is vacuum dried by thick paste, is ground into powder thing B；
Powder thing A and powder thing B is mixed to get the wild jujube extract for the treatment of flu.
Containing wild jujube polysaccharide 138mg/g, CAMP 0.16mg/g, triterpenes 0.19mg/g, alkaloid 0.12mg/g in the wild jujube extract of described treatment flu.
The wild jujube extract of described treatment flu is used for being prepared as tablet, granule, oral liquid, capsule as sole active ingredient, wherein, every tablet is containing described wild jujube extract 0.2g, often bag granule contains described wild jujube extract 0.2g, containing described wild jujube extract 0.2g in every 15ml oral liquid, containing described wild jujube extract 0.2g in every seed lac capsule.
Use the rat fever of LPS induction, take male, the rat of body weight 150-200g 100,
Water is can't help in 6 h fasting, then lumbar injection LPS (50 μ g/kg), induction rat fever, 1 body temperature is surveyed every 0.5 h after injection LPS, monitoring 8 h continuously, stay body temperature more than 38.5 °, One's spirits are drooping, anorectic rat (totally 72, 72 have merely hit 28 there is typical case's cough symptom), it is divided into A at random, B two groups, the wild jujube extract that A body temperature rat every/each 0.2g present invention of giving more than 38.5 ° treats flu is made, the wild jujube extract of the B body temperature rat every more than 38.5 °/every time prepare according to a conventional method to 0.2g is made that (preparation method is, wild jujube is mixed by the weight ratio of 1:10 with water, heating and cooking 30 minutes, take boiling liquid and concentrate cream processed, final vacuum drying, it is ground into powder thing).
Wherein 3 medicines, successive administration 2 days are given in two groups of homogeneous skies of rat of A, B.
After administration terminates, monitor rat temperature for three days on end,
A group rat temperature all recovers normal, and bringing down a fever efficient reaches 100%, and rat mental restoration is normal, and transference cure of coughing, appetite is gradually recovered, and has no toxicity.
B group rat temperature has no recovery, and bringing down a fever efficient is 0, and rat cold symptoms increases the weight of.
Claims (3)
1. the wild jujube extract treating flu, it is characterised in that this extract prepares by the following method:
Slurries are worn in fresh wild jujube stoning, the distilled water adding slurry volume 2 times processes 58 minutes under the microwave that power is 22W, standing takes supernatant liquid, retain residue, being 0.098mpa by supernatant liquid in vacuum, the speed of rotation is 100rpm, and temperature is to be concentrated into, under the Rotary Evaporators of 80-85 DEG C, the thick paste that water content is 8%, thick paste is vacuum dried, is ground into powder thing A；
In residue, add the ethanol of residue volume 8 times 70%, refluxing extraction 2 hours at 80 DEG C, be 0.098mpa by extract in vacuum, the speed of rotation is 100rpm, temperature is to be concentrated into, under the Rotary Evaporators of 65-70 DEG C, the thick paste that water content is 8%, is vacuum dried by thick paste, is ground into powder thing B；
Powder thing A and powder thing B is mixed to get the wild jujube extract for the treatment of flu.
A kind of wild jujube extract treating flu the most according to claim 1, it is characterised in that
Containing wild jujube polysaccharide 138mg/g, CAMP 0.16mg/g, triterpenes 0.19mg/g, alkaloid 0.12mg/g in the wild jujube extract of described treatment flu.
A kind of wild jujube extract treating flu the most according to claim 1, it is characterised in that
The wild jujube extract of described treatment flu is used for being prepared as tablet, granule, oral liquid, capsule as sole active ingredient, wherein, every tablet is containing described wild jujube extract 0.2g, often bag granule contains described wild jujube extract 0.2g, containing described wild jujube extract 0.2g in every 15ml oral liquid, containing described wild jujube extract 0.2g in every seed lac capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610385969.4A CN105853528A (en) | 2016-06-03 | 2016-06-03 | Wild jujube extract for treating cold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610385969.4A CN105853528A (en) | 2016-06-03 | 2016-06-03 | Wild jujube extract for treating cold |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105853528A true CN105853528A (en) | 2016-08-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610385969.4A Pending CN105853528A (en) | 2016-06-03 | 2016-06-03 | Wild jujube extract for treating cold |
Country Status (1)
| Country | Link |
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| CN (1) | CN105853528A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108514583A (en) * | 2018-02-27 | 2018-09-11 | 磐安县派普特生物科技有限公司 | The preparation method of zizyphus jujube extract |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614412A (en) * | 2012-04-27 | 2012-08-01 | 河南太龙药业股份有限公司 | Chinese medicinal composition for clearing heat, dispelling wind, relieving convulsion and soothing nerves |
| CN102670764A (en) * | 2012-05-07 | 2012-09-19 | 南京中医药大学 | Active parts of wild jujube as well as preparation method and application thereof |
| CN103623270A (en) * | 2013-12-08 | 2014-03-12 | 潘健 | Traditional Chinese medicine for treating spleen deficiency type fever |
-
2016
- 2016-06-03 CN CN201610385969.4A patent/CN105853528A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614412A (en) * | 2012-04-27 | 2012-08-01 | 河南太龙药业股份有限公司 | Chinese medicinal composition for clearing heat, dispelling wind, relieving convulsion and soothing nerves |
| CN102670764A (en) * | 2012-05-07 | 2012-09-19 | 南京中医药大学 | Active parts of wild jujube as well as preparation method and application thereof |
| CN103623270A (en) * | 2013-12-08 | 2014-03-12 | 潘健 | Traditional Chinese medicine for treating spleen deficiency type fever |
Non-Patent Citations (3)
| Title |
|---|
| 叶勇: "《制药工艺学》", 28 February 2014, 华南理工大学出版社 * |
| 朱亚民: "《内蒙古植物药志》", 30 September 1993, 内蒙古人民出版社 * |
| 谭云龙 等: "酸枣仁化学成分及其药理作用研究进展", 《时珍国医国药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108514583A (en) * | 2018-02-27 | 2018-09-11 | 磐安县派普特生物科技有限公司 | The preparation method of zizyphus jujube extract |
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20160817 |