CN108514583A - The preparation method of zizyphus jujube extract - Google Patents
The preparation method of zizyphus jujube extract Download PDFInfo
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Abstract
The invention discloses a kind of preparation methods of zizyphus jujube extract, and 10 ~ 20 parts of modified dietary fibers, the precipitation drying that centrifuges, and will obtain after being sufficiently stirred are added in 50 parts of wild jujube extracting solutions；6 ~ 15 portions of disintegrants and 2 ~ 8 parts of diluents are added in the precipitation of the drying, after mixing, 1 ~ 2 part of binder is added and constantly mediates, softwood is made, then utilizes extruder and spheronizator, pellet is made in softwood, obtains zizyphus jujube extract.It has the beneficial effect that：The zizyphus jujube extract that the present invention is prepared is big in intestines and stomach distribution area, small to gastrointestinal irritation, and blood concentration favorable reproducibility, is influenced by gastric emptying small.The skeleton structure of MCC formation is broken in pellet water swelling after eating, and forms hole and active ingredient is promoted to dissolve out.Dietary fiber has specific adsorption and its good hydrophilic property to wild jujube, and residence time is long in enteron aisle, can greatly improve absorptivity of the human body to wild jujube.
Description
Technical field
The present invention relates to plant extracts technical field, the preparation method of specifically a kind of zizyphus jujube extract.
Background technology
Wild jujube alias mountain jujube, wild jujube, spine etc., Rhamnaceae（Rhamnaceae）Zizyphus（Ziziphus）Plant, wild jujube are jujubes
Initial species, it is distributed more widely in China, be wild fruit tree and the Wild Medicinal Plants Resources abounded in northern China.Wild jujube is for I
One of 35 kinds of precious Chinese medicines of state, the classic of TCM《Sheng Nong's herbal classic》It records, and wild jujube " it is sour flat, it cures mainly trusted subordinate and trembles with fear, heat evil knot
Gas, painful limbs, arthritis with fixed pain caused by dampness, long term usage five viscera settling are made light of one's life by commiting suicide macrobiosis ".Studies have shown that spina date seed sweet in flavor and neutral in nature, has calm make of calming the nerves
With, can be extracted in Wild Jujube Leaf sour leaf ketone as treatment coronary heart disease good medicine, wild jujube root can treat insomnia and acute dysentery
Disease, Cortex Ziziphi spinosae Radicis have the effect of antidiarrheal and prevention skin burn, scald.In recent years, British scholar is in the sight to weak disease patient
Examine middle discovery, it is every it is continuous eat wild jujube on time, rehabilitation speed than take multivitamin class merely fast 6 times or more, because
This, wild jujube be proved to have the function of anti-disease, anti-aging always with face nursing and life prolonging.It is more studies have shown that flavone compound is in wild jujube
The polyphenols of generally existing, as that studies it gos deep into, it is anti-inflammatory, disease-resistant that people gradually have found that flavone compound has
Poison, cholagogic, cardiac stimulant, sedation and analgesia, immunological regulation and it is antitumor the effects that, meanwhile, the ortho position phenol pole in wild jujube polyphenol phenolic hydroxyl group
It is easily aoxidized, the ability with very strong inoxidizability and removing free radical.
Invention content
It is small to gastrointestinal irritation that the purpose of the present invention is to provide a kind of, and residence time is long in enteron aisle, absorbs profit
With the preparation method of the high zizyphus jujube extract of rate.
To achieve the above object, technical solution provided by the invention is：The preparation method of zizyphus jujube extract, including pellet system
It is standby：10 ~ 20 parts of modified dietary fibers are added in 50 parts of wild jujube extracting solutions, are centrifuged after being sufficiently stirred, and obtained precipitation is done
It is dry；6 ~ 15 portions of disintegrants and 2 ~ 8 parts of diluents are added in the precipitation of the drying, after mixing, 1 ~ 2 part of binder are added
It constantly mediates, softwood is made, then utilize extruder and spheronizator, pellet is made in softwood, obtains zizyphus jujube extract.Above-mentioned system
Standby obtained zizyphus jujube extract is big in intestines and stomach distribution area, small to gastrointestinal irritation, and blood concentration favorable reproducibility, by
Gastric emptying influences small.The skeleton structure of MCC formation is broken in pellet water swelling after eating, and forms hole and promotes active ingredient molten
Go out.The good hydrophilic property of dietary fiber, residence time is long in enteron aisle, and human body is high to the absorptivity of wild jujube.
Disintegrant is L-HPC；Diluent is MCC；Binder is second alcohol and water.
The preparation method of zizyphus jujube extract further includes the preparation of wild jujube extracting solution：2 ~ 5 times of volumes 60 are added in kudzu-vine root powder
~ 70% ethanol solution, 4 ~ 15 DEG C of constant-temperature ultrasonics extract 30 ~ 40min, and decompression filters, and 60 ~ 70% are continuously added in filter residue
Ethanol solution repeats 1 ~ 4 time, merging filtrate；The saturation butanol solution of 1 ~ 3 times of dropwise addition kudzu-vine root powder volume in filtrate, and
Constant temperature stirs 1.5 ~ 2.8h at 50 ~ 70 DEG C, stands 1 ~ 3h, takes supernatant, continue the saturation n-butanol of 1 ~ 2 times of dropwise addition in precipitation
Solution repeats 2 ~ 4 times, merges supernatant；1/10 ~ 1/8,65 ~ 75% ethanol solutions of concentrated supernatant to original volume are elution
Agent carries out adsorption and enrichment using D101 macroporous absorbent resins, and low temperature drying obtains wild jujube crude product, and weight is carried out by solvent of glacial acetic acid
Crystallization, obtains zizyphus jujube extract.Impurity content is few in zizyphus jujube extract obtained above, and quality is good, have anti-disease, anti-aging always with
Face nursing and life prolonging, anti-inflammatory, antiviral, cholagogic, cardiac stimulant, sedation and analgesia, immunological regulation and it is antitumor the effects that, and with very strong
Inoxidizability and the ability for removing free radical.
The preparation method of zizyphus jujube extract further includes the preparation of modified dietary fiber：In solid-liquid ratio 1:6 ~ 9 dietary fiber
0.05 ~ 0.07% β-is added in solution and dredges base ethyl alcohol and 0.2 ~ 0.6% cellulase degradation, enzymatic hydrolysis condition is pH4.5 ~ 5.8, temperature
It it is 45 ~ 55 DEG C, enzymolysis time is 3 ~ 4h.It centrifuges and is dried to obtain enzymolysis modified dietary fiber, then use ion sputtering film coating method
Surface gold-plating is carried out, extruding obtains modified dietary fiber.The long-chain of dietary fiber molecule is broken after enzymolysis, microcrystalline cellulose
Destructurized, the hydrogen bond between cellulosic molecule is opened, and more hydroxyls is made to be exposed, and apparent hole occurs in fiber surface
Shape structure, forms more cavity, has specific adsorption to wild jujube.The thin base ethyl alcohol of β-is added in digesting substrate to be significantly improved
Dietary fiber makes wild jujube be evenly distributed in fiber surface the adsorption capacity of wild jujube.
Dietary fiber is that 20 ~ 30% common oats fibres, lemon fiber 10 ~ 20%, Semen Tritici aestivi fiber 40 ~ 50% and surplus cactus are fine
Dimension.The ingredient collocation of above-mentioned dietary fiber is not only good to the adsorption capacity of wild jujube, moreover it is possible to preferably to promote stomach for most preferably
It wriggles, accelerates absorption of the human body to wild jujube.
Compared with the prior art, the advantages of the present invention are as follows：The zizyphus jujube extract that the present invention is prepared is in intestines and stomach point
Cloth area is big, small to gastrointestinal irritation, and blood concentration favorable reproducibility, is influenced by gastric emptying small.Pellet absorbs water after eating
The skeleton structure of MCC formation is broken in expansion, forms hole and active ingredient is promoted to dissolve out.Dietary fiber has specific suction to wild jujube
Attached and its good hydrophilic property, residence time is long in enteron aisle, can greatly improve absorptivity of the human body to wild jujube.Acid obtained above
Impurity content is few in jujube extract, and quality is good, has anti-disease, anti-aging always and face nursing and life prolonging, anti-inflammatory, antiviral, cholagogic, cardiac stimulant, town
It is quiet analgesia, immunological regulation and it is antitumor the effects that, and with very strong inoxidizability and remove free radical ability.
Specific implementation mode
The present invention program is described further below by embodiment：
Embodiment 1：
The preparation method of zizyphus jujube extract, includes the following steps：
1) preparation method of zizyphus jujube extract further includes the preparation of wild jujube extracting solution：3 times of volumes 65% of addition in kudzu-vine root powder
Ethanol solution, 8 DEG C of constant-temperature ultrasonics extract 34min, and decompression filters, and 65% ethanol solution is continuously added in filter residue, repeats 3
It is secondary, merging filtrate；The saturation butanol solution of 1 ~ 3 times of kudzu-vine root powder volume is added dropwise in filtrate, and constant temperature stirs 2h at 60 DEG C,
2h is stood, supernatant is taken, continues that 1.8 times of saturation butanol solution is added dropwise in precipitation, is repeated 3 times, merges supernatant；Concentration
Supernatant to the 1/8 of original volume, 70% ethanol solution is eluant, eluent, and adsorption and enrichment is carried out using D101 macroporous absorbent resins, low
Temperature is dried to obtain wild jujube crude product, is recrystallized by solvent of glacial acetic acid, and zizyphus jujube extract is obtained.Wild jujube extraction obtained above
Impurity content is few in object, and quality is good, has anti-disease, anti-aging always and face nursing and life prolonging, anti-inflammatory, antiviral, cholagogic, cardiac stimulant, calm town
Bitterly, immunological regulation and it is antitumor the effects that, and with very strong inoxidizability and remove free radical ability；
2）The preparation of modified dietary fiber：In solid-liquid ratio 1:0.06% β-is added in 7 dietary fiber solution and dredges base ethyl alcohol and 0.5%
Cellulase degradation, enzymatic hydrolysis condition pH5.0, temperature are 50 DEG C, enzymolysis time 3.6h.It centrifuges and is dried to obtain enzymolysis modified
Dietary fiber, then carries out surface gold-plating with ion sputtering film coating method, and extruding obtains modified dietary fiber.Dietary fiber after enzymolysis
The long-chain of molecule is broken, and microcrystalline cellulose is destructurized, and the hydrogen bond between cellulosic molecule is opened, and makes more hydroxyls
It is exposed, apparent cavernous structure occurs in fiber surface, forms more cavity, has specific adsorption to wild jujube.It is digesting
The thin base ethyl alcohol of β-is added in substrate can significantly improve dietary fiber to the adsorption capacity of wild jujube, and wild jujube is made to be evenly distributed in fiber
Surface.Dietary fiber is 26% common oats fibre, lemon fiber 18%, Semen Tritici aestivi fiber 45% and 11% cactus fiber.Above-mentioned diet is fine
The ingredient collocation of dimension is not only good to the adsorption capacity of wild jujube for most preferably, moreover it is possible to preferably promote the wriggling of stomach, accelerate human body
Absorption to wild jujube；
3）The preparation of pellet：16 parts of modified dietary fibers are added in 50 parts of wild jujube extracting solutions, are centrifuged after being sufficiently stirred, and will
The precipitation drying arrived；13 parts of disintegrant L-HPC and 5 parts of diluent MCC are added in the precipitation of the drying, after mixing,
1.4 parts of binder second alcohol and waters are added constantly to mediate, softwood is made, then utilizes extruder and spheronizator, softwood is made micro-
Ball obtains zizyphus jujube extract.The above-mentioned zizyphus jujube extract being prepared is big in intestines and stomach distribution area, to gastrointestinal irritation
It is small, and blood concentration favorable reproducibility, it is influenced by gastric emptying small.The skeleton knot of MCC formation is broken in pellet water swelling after eating
Structure forms hole and active ingredient is promoted to dissolve out.The good hydrophilic property of dietary fiber, residence time is long in enteron aisle, and human body is to acid
The absorptivity of jujube is high.
Embodiment 2：
The preparation method of zizyphus jujube extract, includes the following steps：
1) preparation method of zizyphus jujube extract further includes the preparation of wild jujube extracting solution：3.6 times of volumes 65% are added in kudzu-vine root powder
Ethanol solution, 5 DEG C of constant-temperature ultrasonics extract 39min, and decompression filters, and 65% ethanol solution is continuously added in filter residue, repeats
3 times, merging filtrate；The saturation butanol solution of 1 ~ 3 times of kudzu-vine root powder volume is added dropwise in filtrate, and constant temperature stirs at 55 DEG C
2.6h stands 2h, takes supernatant, continues that 1.8 times of saturation butanol solution is added dropwise in precipitation, is repeated 3 times, merges supernatant
Liquid；Concentrated supernatant to the 1/8 of original volume, 70% ethanol solution is eluant, eluent, is adsorbed using D101 macroporous absorbent resins
Enrichment, low temperature drying obtain wild jujube crude product, are recrystallized by solvent of glacial acetic acid, obtain zizyphus jujube extract.It is obtained above
Impurity content is few in zizyphus jujube extract, and quality is good, has anti-disease, anti-aging always and face nursing and life prolonging, anti-inflammatory, antiviral, cholagogic, cardiac stimulant,
Sedation and analgesia, immunological regulation and it is antitumor the effects that, and with very strong inoxidizability and remove free radical ability；
2）The preparation of modified dietary fiber：In solid-liquid ratio 1:0.06% β-is added in 7 dietary fiber solution and dredges base ethyl alcohol and 0.5%
Cellulase degradation, enzymatic hydrolysis condition pH5.0, temperature are 50 DEG C, enzymolysis time 3.6h.It centrifuges and is dried to obtain enzymolysis modified
Dietary fiber, then carries out surface gold-plating with ion sputtering film coating method, and extruding obtains modified dietary fiber.Dietary fiber after enzymolysis
The long-chain of molecule is broken, and microcrystalline cellulose is destructurized, and the hydrogen bond between cellulosic molecule is opened, and makes more hydroxyls
It is exposed, apparent cavernous structure occurs in fiber surface, forms more cavity, has specific adsorption to wild jujube.It is digesting
The thin base ethyl alcohol of β-is added in substrate can significantly improve dietary fiber to the adsorption capacity of wild jujube, and wild jujube is made to be evenly distributed in fiber
Surface.Dietary fiber is 26% common oats fibre, lemon fiber 18%, Semen Tritici aestivi fiber 45% and 11% cactus fiber.Above-mentioned diet is fine
The ingredient collocation of dimension is not only good to the adsorption capacity of wild jujube for most preferably, moreover it is possible to preferably promote the wriggling of stomach, accelerate human body
Absorption to wild jujube；
3）The preparation of pellet：13 parts of modified dietary fibers are added in 50 parts of wild jujube extracting solutions, are centrifuged after being sufficiently stirred, and will
The precipitation drying arrived；13 parts of disintegrant L-HPC and 5 parts of diluent MCC are added in the precipitation of the drying, after mixing,
1.2 parts of binder second alcohol and waters are added constantly to mediate, softwood is made, then utilizes extruder and spheronizator, softwood is made micro-
Ball obtains zizyphus jujube extract.The above-mentioned zizyphus jujube extract being prepared is big in intestines and stomach distribution area, to gastrointestinal irritation
It is small, and blood concentration favorable reproducibility, it is influenced by gastric emptying small.The skeleton knot of MCC formation is broken in pellet water swelling after eating
Structure forms hole and active ingredient is promoted to dissolve out.The good hydrophilic property of dietary fiber, residence time is long in enteron aisle, and human body is to acid
The absorptivity of jujube is high.
Embodiment 3：
The preparation method of zizyphus jujube extract, includes the following steps：
1) preparation method of zizyphus jujube extract further includes the preparation of wild jujube extracting solution：3 times of volumes 65% of addition in kudzu-vine root powder
Ethanol solution, 8 DEG C of constant-temperature ultrasonics extract 34min, and decompression filters, and 65% ethanol solution is continuously added in filter residue, repeats 3
It is secondary, merging filtrate；The saturation butanol solution of 1 ~ 3 times of kudzu-vine root powder volume is added dropwise in filtrate, and constant temperature stirs 2h at 60 DEG C,
2h is stood, supernatant is taken, continues that 1.8 times of saturation butanol solution is added dropwise in precipitation, is repeated 3 times, merges supernatant；Concentration
Supernatant to the 1/8 of original volume, 70% ethanol solution is eluant, eluent, and adsorption and enrichment is carried out using D101 macroporous absorbent resins, low
Temperature is dried to obtain wild jujube crude product, is recrystallized by solvent of glacial acetic acid, and zizyphus jujube extract is obtained.Wild jujube extraction obtained above
Impurity content is few in object, and quality is good, has anti-disease, anti-aging always and face nursing and life prolonging, anti-inflammatory, antiviral, cholagogic, cardiac stimulant, calm town
Bitterly, immunological regulation and it is antitumor the effects that, and with very strong inoxidizability and remove free radical ability；
2）The preparation of modified dietary fiber：In solid-liquid ratio 1:0.04% β-is added in 4 dietary fiber solution and dredges base ethyl alcohol and 0.3%
Cellulase degradation, enzymatic hydrolysis condition pH5.0, temperature are 55 DEG C, enzymolysis time 3.6h.It centrifuges and is dried to obtain enzymolysis modified
Dietary fiber, then carries out surface gold-plating with ion sputtering film coating method, and extruding obtains modified dietary fiber.Dietary fiber after enzymolysis
The long-chain of molecule is broken, and microcrystalline cellulose is destructurized, and the hydrogen bond between cellulosic molecule is opened, and makes more hydroxyls
It is exposed, apparent cavernous structure occurs in fiber surface, forms more cavity, has specific adsorption to wild jujube.It is digesting
The thin base ethyl alcohol of β-is added in substrate can significantly improve dietary fiber to the adsorption capacity of wild jujube, and wild jujube is made to be evenly distributed in fiber
Surface.Dietary fiber is 26% common oats fibre, lemon fiber 18%, Semen Tritici aestivi fiber 45% and 11% cactus fiber.Above-mentioned diet is fine
The ingredient collocation of dimension is not only good to the adsorption capacity of wild jujube for most preferably, moreover it is possible to preferably promote the wriggling of stomach, accelerate human body
Absorption to wild jujube；
3）The preparation of pellet：12 parts of modified dietary fibers are added in 50 parts of wild jujube extracting solutions, are centrifuged after being sufficiently stirred, and will
The precipitation drying arrived；13 parts of disintegrant L-HPC and 5 parts of diluent MCC are added in the precipitation of the drying, after mixing,
1.4 parts of binder second alcohol and waters are added constantly to mediate, softwood is made, then utilizes extruder and spheronizator, softwood is made micro-
Ball obtains zizyphus jujube extract.The above-mentioned zizyphus jujube extract being prepared is big in intestines and stomach distribution area, to gastrointestinal irritation
It is small, and blood concentration favorable reproducibility, it is influenced by gastric emptying small.The skeleton knot of MCC formation is broken in pellet water swelling after eating
Structure forms hole and active ingredient is promoted to dissolve out.The good hydrophilic property of dietary fiber, residence time is long in enteron aisle, and human body is to acid
The absorptivity of jujube is high.
Routine operation in the operating procedure of the present invention is well known to those skilled in the art, herein without repeating.
Technical scheme of the present invention is described in detail in embodiment described above, it should be understood that the above is only
For specific embodiments of the present invention, it is not intended to restrict the invention, all any modifications made in the spirit of the present invention,
Supplement or similar fashion replacement etc., should all be included in the protection scope of the present invention.
Claims (8)
1. the preparation method of zizyphus jujube extract, it is characterised in that prepared including pellet：10 ~ 20 are added in 50 parts of wild jujube extracting solutions
Part modified dietary fiber, the precipitation drying that centrifuges, and will obtain after being sufficiently stirred；6 ~ 15 parts are added in the precipitation of the drying
Disintegrant and 2 ~ 8 parts of diluents are added 1 ~ 2 part of binder and constantly mediate, softwood is made after mixing, then utilize extrusion
Softwood is made pellet, obtains zizyphus jujube extract by machine and spheronizator.
2. the preparation method of zizyphus jujube extract according to claim 1, it is characterised in that：The disintegrant is L-HPC.
3. the preparation method of zizyphus jujube extract according to claim 1, it is characterised in that：The diluent is MCC.
4. the preparation method of zizyphus jujube extract according to claim 1, it is characterised in that：The binder be ethyl alcohol and
Water.
5. the preparation method of zizyphus jujube extract according to claim 1, it is characterised in that：The preparation method further includes
The preparation of wild jujube extracting solution：The ethanol solution of 2 ~ 5 times of volumes 60 ~ 70%, 4 ~ 15 DEG C of constant-temperature ultrasonic extractions are added in kudzu-vine root powder
30 ~ 40min, decompression filter, and 60 ~ 70% ethanol solution is continuously added in filter residue, repeat 1 ~ 4 time, merging filtrate；In filtrate
The middle saturation butanol solution that 1 ~ 3 times of kudzu-vine root powder volume is added dropwise, and constant temperature stirs 1.5 ~ 2.8h at 50 ~ 70 DEG C, stands 1 ~ 3h,
Supernatant is taken, continues the saturation butanol solution of 1 ~ 2 times of dropwise addition in precipitation, is repeated 2 ~ 4 times, supernatant is merged；Concentrate supernatant
1/10 ~ 1/8,65 ~ 75% ethanol solutions of liquid to original volume are eluant, eluent, and it is rich to carry out absorption using D101 macroporous absorbent resins
Collection, low temperature drying obtain wild jujube crude product, are recrystallized by solvent of glacial acetic acid, obtain zizyphus jujube extract.
6. the preparation method of zizyphus jujube extract according to claim 1, it is characterised in that：The preparation method further includes
The preparation of modified dietary fiber：In solid-liquid ratio 1:0.05 ~ 0.07% β-is added in 6 ~ 9 dietary fiber solution and dredges base ethyl alcohol and 0.2
~ 0.6% cellulase degradation centrifuges and is dried to obtain enzymolysis modified dietary fiber, then carries out surface with ion sputtering film coating method
Gold-plated, extruding obtains modified dietary fiber.
7. the preparation method of zizyphus jujube extract according to claim 6, it is characterised in that：The dietary fiber be 20 ~
30% common oats fibre, lemon fiber 10 ~ 20%, Semen Tritici aestivi fiber 40 ~ 50% and surplus cactus fiber.
8. the preparation method of zizyphus jujube extract according to claim 6, it is characterised in that：The enzymatic hydrolysis condition is
PH4.5 ~ 5.8, temperature are 45 ~ 55 DEG C, and enzymolysis time is 3 ~ 4h.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670764A (en) * | 2012-05-07 | 2012-09-19 | 南京中医药大学 | Active parts of wild jujube as well as preparation method and application thereof |
| CN105853528A (en) * | 2016-06-03 | 2016-08-17 | 陈瑞 | Wild jujube extract for treating cold |
| CN106857825A (en) * | 2015-12-10 | 2017-06-20 | 青岛宏致复合织造有限公司 | Improve the sour milk powder of sleep quality |
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2018
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670764A (en) * | 2012-05-07 | 2012-09-19 | 南京中医药大学 | Active parts of wild jujube as well as preparation method and application thereof |
| CN106857825A (en) * | 2015-12-10 | 2017-06-20 | 青岛宏致复合织造有限公司 | Improve the sour milk powder of sleep quality |
| CN105853528A (en) * | 2016-06-03 | 2016-08-17 | 陈瑞 | Wild jujube extract for treating cold |
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