CN108310338A - A kind of soluble micropin and preparation method thereof of losing weight - Google Patents
A kind of soluble micropin and preparation method thereof of losing weight Download PDFInfo
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- CN108310338A CN108310338A CN201810167836.9A CN201810167836A CN108310338A CN 108310338 A CN108310338 A CN 108310338A CN 201810167836 A CN201810167836 A CN 201810167836A CN 108310338 A CN108310338 A CN 108310338A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
- A61F5/0003—Apparatus for the treatment of obesity; Anti-eating devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
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Abstract
The invention discloses a kind of soluble weight-reducing micropins, including needle point (1), and the needle point (1) includes active ingredient, and in parts by weight, the active ingredient includes：10 15 parts of Astragalus Root P.E, 38 parts of Rhizoma Atractylodis Macrocephalae extract, 25 parts of rhizome of chuanxiong extract, 5 12 parts of radix-polygoni multiflori extract, 4 10 parts of papaya extractives, 10 20 parts of Honegsukle flower P.E, 13 parts of Alisma extract, 26 parts of dried orange peel extracts, 15 20 parts of cassia seed, 14 parts of licorice, 36 parts of Ginger P.E, 10 15 parts of Fructus Monordicae extract, 15 20 parts of Lotus Leafextract, 40 50 parts of wax gourd extract, 10 20 parts of red rose extract, 28 parts of chrysanthemum extract, 3 10 parts of Fructus Rosae Normalis extract.This micropin fat-reducing effect is apparent.
Description
Technical field
The invention belongs to medical instruments fields, and in particular to a kind of soluble micropin and preparation method thereof of losing weight.
Background technology
Obesity refers to a degree of apparent overweight blocked up with fat deposit, is body fat, especially triglycerides gathers
A kind of state caused by excessive.Body fat accumulation is caused excessively to be made since food intake is excessive or the change of organism metabolism
Increase and cause human pathology, physiological change or latent at excess weight.Obesity is a kind of generation chronic caused by many factors
Thanking property disease is increased with the volume of body fat cell and cell number and the percentage of body fat percentage of liveweight is caused to increase extremely and certain
With the characteristics of the excessive deposition fat in part.
Edema type obesity, pressure-type obesity, anemic obesity, fatigue type obesity, engorgement obesity etc..Obesity is not only
Health is influenced, and has an effect on mental health.
There are many weight-reducing modes, including changes lifestyles, drug therapy, surgical operation therapy etc..For have it is powerful from
For the people of my restraining force, change obesity by changing lifestyles, to realize weight-reducing, not all people can be real
It is existing, and the obesity symptom having can not be lost weight by changing lifestyles, in other words almost without effect.Drug therapy for
Effect is obvious for most people, but there are prodigious side effects, and for somebody's effect nor apparent.
Surgical operation is come to treat obesity be most effective means, and mainly for severe simple obesity patient, the people for generally requiring weight-reducing is not suitable for
Operative treatment.
Invention content
The main object of the present invention is to provide for a kind of soluble micropin and preparation method thereof of losing weight, to solve existing subtract
Fertile drug or weight-reducing mode fat-reducing effect are bad, have the problem of side effect.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of soluble weight-reducing micropin, including needle point 1, the needle point 1 includes active ingredient, in parts by weight, described
Active ingredient includes：
10-15 parts of Astragalus Root P.E, 3-8 parts of Rhizoma Atractylodis Macrocephalae extract, 2-5 parts of rhizome of chuanxiong extract, 5-12 parts of radix-polygoni multiflori extract,
4-10 parts of papaya extractives, 10-20 parts of Honegsukle flower P.E, 1-3 parts of Alisma extract, 2-6 parts of dried orange peel extracts, cassia seed
15-20 parts, 1-4 parts of licorice, 3-6 parts of Ginger P.E, 10-15 parts of Fructus Monordicae extract, Lotus Leafextract 15-20
Part, 40-50 parts of wax gourd extract, 10-20 parts of red rose extract, 2-8 parts of chrysanthemum extract, 3-10 parts of Fructus Rosae Normalis extract.
Preferably, in parts by weight, the active ingredient includes：11-13 parts of Astragalus Root P.E, Rhizoma Atractylodis Macrocephalae extract 4-6
Part, 3-4 parts of rhizome of chuanxiong extract, 6-10 parts of radix-polygoni multiflori extract, 6-8 parts of papaya extractives, 15-18 parts of Honegsukle flower P.E, pool
Rush down 1-3 parts of extract, 3-5 parts of dried orange peel extracts, 16-18 parts of cassia seed, 2-3 parts of licorice, 4-5 parts of Ginger P.E,
11-14 parts of Fructus Monordicae extract, 16-18 parts of Lotus Leafextract, 42-49 parts of wax gourd extract, 14-18 parts of red rose extract,
4-6 parts of chrysanthemum extract, 4-8 parts of Fructus Rosae Normalis extract.
Preferably, in parts by weight, the active ingredient includes：12 parts of Astragalus Root P.E, 5 parts of Rhizoma Atractylodis Macrocephalae extract, river
3.5 parts of vault extract, 9 parts of radix-polygoni multiflori extract, 8 parts of papaya extractives, 15 parts of Honegsukle flower P.E, 2 parts of Alisma extract are old
4 parts of bark extract, 18 parts of cassia seed, 3 parts of licorice, 5 parts of Ginger P.E, 13 parts of Fructus Monordicae extract, lotus leaf extraction
18 parts of object, 45 parts of wax gourd extract, 15 parts of red rose extract, 5 parts of chrysanthemum extract, 6 parts of Fructus Rosae Normalis extract.
Preferably, in parts by weight, further include 8-22 parts of Duyun Maojian Tea extract.
Preferably, further include 7-30 parts of decoyl salicylic acid, 0.2-1.8 parts of sodium hydroxide, 50-75 parts of mandelic acid, 1,2- oneself
3-8 parts of glycol, pungent glycol 1-3 parts.
Preferably, further include surrounding layer, the material for forming surrounding layer is selected from the list of vinyl pyrrolidone and its derivative
Body polymer or copolymer, ethyl cellulose, hyaluronic acid, glucan, soluplus, hydroxypropyl methylcellulose, methacrylic acid
Copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides chondroitin, collagen, chitosan, branch
It is one or more in starch, polysaccharide polymer.
Preferably, the material for forming surrounding layer is hyaluronic acid, and the mass concentration of the hyaluronic acid is 15%~20%.
A kind of preparation method of soluble weight-reducing micropin described in claim 1, includes the following steps：
S1：Prepare Astragalus Root P.E, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, radix-polygoni multiflori extract, papaya extractives, gold and silver
Flower extract, Alisma extract, dried orange peel extracts, cassia seed, licorice, Ginger P.E, Fructus Monordicae extract, lotus leaf
Extract, wax gourd extract, red rose extract, chrysanthemum extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract is spare；
S2：By weight, the Astragalus Root P.E obtained by weighing respectively in step S1, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, what
Tuber of multiflower knotweed extract, papaya extractives, Honegsukle flower P.E, Alisma extract, dried orange peel extracts, cassia seed, licorice are raw
Ginger extract, Fructus Monordicae extract, Lotus Leafextract, wax gourd extract, red rose extract, chrysanthemum extract, Rosa roxburghii Tratt extraction
Object, Duyun Maojian Tea extract are added 300-400 parts of deionized water, are mixed evenly, filter to take filtrate；
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble weight-reducing micropin
Active ingredient；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made；
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble weight-reducing micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble weight-reducing micropin again.
A kind of microneedle configuration of soluble weight-reducing, the microneedle configuration of the soluble weight-reducing include needle point 1, surrounding layer 2, connect
Layer 3 and substrate 4 are connect, the surrounding layer 2 is coated on 1 outside of the needle point, and 1 outside of the needle point is zigzag；The needle point 1,
Surrounding layer 2 is connect by the articulamentum 3 with the substrate 4.
Preferably, the height of the needle point 1 is 50-500 microns.
Compared with prior art, soluble weight-reducing micropin of the present invention and preparation method thereof at least has the advantages that：
1) active ingredient in the present invention, selects by the height to various slimming medicines and carries out optimal combination, to
The dosage and toxic side effect for reducing each drug, expand its safe range and use scope.
2) Astragalus Root P.E in active ingredient of the present invention, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, radix-polygoni multiflori extract, wood
Melon extract, Honegsukle flower P.E, Alisma extract, dried orange peel extracts, cassia seed, licorice, Ginger P.E, arhat
Berry extract, Lotus Leafextract, wax gourd extract, red rose extract, chrysanthemum extract, Fructus Rosae Normalis extract, Duyun Maojian Tea
Extract can improve the metabolism of skin while weight-reducing, fundamentally lose weight.
3) soluble weight-reducing micropin provided by the invention has biodegradable, can be completely dissolved or drop in skin
Solution.Prepare surrounding layer using hyaluronic acid, on the one hand can protect active ingredient, avoid active ingredient contact external environment and by
Aoxidize or go bad etc.；On the other hand, hyaluronic acid can dissolve rapidly, discharge the active ingredient of the inside, and solubility weight-reducing is micro-
Needle set has certain slow release effect.
4) soluble weight-reducing micropin provided by the invention can rapidly dissolve inside skin, can compared with oral conditioning
Substantially shorten treatment time, avoids drug from absorbing the content for lowering active ingredient through gastrointestinal disturbances, or because ensureing active ingredient
Content and the dosage that must not be not added with big active ingredient improve cost.
5) soluble weight-reducing micropin provided by the invention can be completely dissolved so that active ingredient free of losses improves effective
The utilization rate of ingredient is directly applied to the metabolism of treated region cortex, efficient, at low cost, can have been avoided
Effect ingredient causes unnecessary stimulation to other positions.
6) weight-reducing micropin provided by the invention is readily produced, transports and stores, and reduces cost.
7) weight-reducing micropin provided by the invention coordinates corresponding instrument, or does not have to instrument, be in can Self-operating, nothing
It need to go to beauty parlor.Not only safety, but it is time saving, economical.
Description of the drawings
Fig. 1 is the structural schematic diagram of the soluble micropin of losing weight of the present invention.
Specific implementation mode
The invention will be further described with reference to the accompanying drawings and examples, and following embodiment is descriptive, is not
Limited, protection scope of the present invention cannot be limited with this.
Keep the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction in the embodiment of the present invention
Attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is this
Invention a part of the embodiment, instead of all the embodiments.Embodiments of the present invention, which are generally described and illustrated herein in the accompanying drawings
Component can arrange and design with a variety of different configurations.Therefore, the implementation to the present invention provided in the accompanying drawings below
The detailed description of example is not intended to limit the range of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end
Same or similar label indicates same or similar element or element with the same or similar functions.Below with reference to attached
The embodiment of figure description is exemplary, it is intended to for explaining the present invention, and is not considered as limiting the invention.
Extract in the present invention：Refer to a kind of by impregnating or being mixed in solvent by the substance of extract to be obtained
The solution for extracting and obtaining.Extraction process can carry out with the help of selection suitable solvent, such as：Water, ethyl alcohol, ethanol/water
Mixture, methanol, propyl alcohol, butanol, chloroform, acetone or other organic solvents, and by isolation, diafiltration, decoction, counter-current extraction,
Ultrasonic wave, microwave, supercritical fluid extraction method obtain extract, extract is further concentrated by evaporation, and obtains medicinal extract and dry
Dry extract.
In the formula of the present invention, the characteristics of each component and function is as follows：
Radix Astragali：It has enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial
Effect.
Rhizoma Atractylodis Macrocephalae：With strengthening the spleen and replenishing qi, the effect of eliminate dampness and have diuretic effect, hidroschesis, tocolysis, it to be used for spleen eating less, abdominal distention diarrhea, phlegm and retained fluid
Feel dizzy and heart palpitations, oedema, spontaneous perspiration, fetal irritability.
Rhizome of chuanxiong：Blood-activating and qi-promoting, wind-expelling pain-stopping, promote breath and open depression.
The fleece-flower root：Nourishing the blood and yin；It relaxes bowel；Preventing malaria；Wind-dispelling；Removing toxic substances.Main deficiency of blood Light-headedness；Palpitaition；Insomnia；Liver kidney
The soreness and weakness of waist and knees of the deficiency of Yin；Poliosis；Tinnitus；Seminal emission；Dry constipation of intestines；Chronic malaria body void；Rubella itch；Sore carbuncle；Scrofula；Hemorrhoid.
Pawpaw：With prevention hypertension, ephritis, constipation and it is aid digestion, control stomach trouble, have the new section metabolism of promotion and anti-to human body
The effect of effect of aging, also beauty and skin care beauty treatment.
Honeysuckle：It is clearing heat and detoxicating.
Rhizoma alismatis：For difficult urination, oedema turgor, oliguria of having loose bowels, phlegmatic vertigo, puckery pain of heat gonorrhea, hyperlipidemia.
Dried orange peel：For abdominal fullness and distention, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Cassia seed：It relaxes bowel, constipation and hyperlipidemia, hypertension are treated in lipid-loweringing improving eyesight.It clears liver and improve vision, sharp water defaecation has
Laxative action, reducing blood pressure and blood fat.
Radix Glycyrrhizae：Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc..
Ginger：For deficiency-cold in spleen and stomach, disorder of stomach-energy, anorexia, nausea and vomiting, chill or cough and anemofrigid cold,
Fever with aversion to wind etc..
Siraitia grosvenorii：Anti-aging, beauty benefit skin, reducing blood lipid, weight-reducing.
Lotus leaf：The effect of clearing away summerheat, sending up the lucid yang, dissipate stasis of blood hemostasis.
Wax gourd：There is the effect of anti-inflammatory, diuresis, detumescence.
Red rose：Enter liver, the spleen channel, can promoting qi circulation and removing obstruction in the collateral and blood removing blood stasis and analgesics, Bearberry Extract dissipates stasis of blood effect, anti-to skin care
Wrinkle, wound healing, ulcerative carbuncle swelling and pain are all effective.Modern study finds that rose contains abundant vitamin, also tannic acid, can improve interior
Dyssecretosis problem.
Chrysanthemum：Anemopyretic cold, dizziness of having a headache, red eye, swell pain, eyes is dim-sighted, sore and toxic.
Rosa roxburghii Tratt：Have the function of to adjust body's immunity, anti-aging, antiatherosclerosis and antitumor etc..
Other materials or product in the present invention, be it is commercially available, unless otherwise indicated.
The present invention provides a kind of soluble weight-reducing micropin, including needle point 1, and the needle point 1 includes active ingredient, according to weight
Part meter, active ingredient include：10-15 parts of Astragalus Root P.E, 3-8 parts of Rhizoma Atractylodis Macrocephalae extract, 2-5 parts of rhizome of chuanxiong extract, the fleece-flower root carries
Take 5-12 parts of object, 4-10 parts of papaya extractives, 10-20 parts of Honegsukle flower P.E, 1-3 parts of Alisma extract, dried orange peel extracts 2-6
Part, 15-20 parts of cassia seed, 1-4 parts of licorice, 3-6 parts of Ginger P.E, 10-15 parts of Fructus Monordicae extract, lotus leaf extraction
15-20 parts of object, 40-50 parts of wax gourd extract, 10-20 parts of red rose extract, 2-8 parts of chrysanthemum extract, Fructus Rosae Normalis extract 3-
10 parts, 8-22 parts of Duyun Maojian Tea extract, 7-30 parts of decoyl salicylic acid, 0.2-1.8 parts of sodium hydroxide, 50-75 parts of mandelic acid,
1,2- 3-8 parts of hexylene glycol, pungent glycol 1-3 parts.
Soluble weight-reducing micropin provided by the invention further includes surrounding layer.Surrounding layer mainly uses hyaluronic acid.Hyalomitome
Acid shows that a variety of important physiological functions, such as lubricating joint are adjusted with its unique molecular structure and physicochemical property in body
Save the permeability of vascular wall, regulatory protein matter, Water-Electrolyte diffusion and operating, promotion, acceleration of wound healing etc..Certain surrounding layer
Other high molecular materials may be used, such as vinyl pyrrolidone and its monomer-polymer or copolymer of derivative, ethyl is fine
Dimension element, hyaluronic acid, glucan, soluplus (Polyvinylcaprolactames-polyvinyl acetate-polyethylene glycol graft copolymerization
Object), hydroxypropyl methylcellulose, methacrylic acid copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides
One or more of chondroitin, collagen, chitosan, amylopectin, polysaccharide polymer etc..
The preparation method of above-mentioned soluble weight-reducing micropin, mainly includes the following steps that：
S1：Prepare Astragalus Root P.E, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, radix-polygoni multiflori extract, papaya extractives, gold and silver
Flower extract, Alisma extract, dried orange peel extracts, cassia seed, licorice, Ginger P.E, Fructus Monordicae extract, lotus leaf
Extract, wax gourd extract, red rose extract, chrysanthemum extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract are spare；
S2：By weight, the Astragalus Root P.E obtained by weighing respectively in step S1, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, what
Tuber of multiflower knotweed extract, papaya extractives, Honegsukle flower P.E, Alisma extract, dried orange peel extracts, cassia seed, licorice are raw
Ginger extract, Fructus Monordicae extract, Lotus Leafextract, wax gourd extract, red rose extract, chrysanthemum extract, Rosa roxburghii Tratt extraction
Object, Duyun Maojian Tea extract are added 300-400 parts of deionized water, are mixed evenly, filter to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble weight-reducing micropin
Active ingredient.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble weight-reducing micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble weight-reducing micropin again.
The microneedle configuration of solubility weight-reducing includes needle point 1, surrounding layer 2, articulamentum 3 and substrate 4, and the surrounding layer 2 coats
In 1 outside of the needle point, 1 outside of the needle point is zigzag；The needle point 1, surrounding layer 2 by the articulamentum 3 with it is described
Substrate 4 connects；1 global shape of the needle point is cone or triangle.The height of the needle point 1 is 50-500 microns.
Embodiment 1
The present embodiment provides a kind of soluble weight-reducing micropins, including needle point 1, and the needle point 1 includes active ingredient, according to weight
Part meter is measured, active ingredient includes：10 parts of Astragalus Root P.E, 4 parts of Rhizoma Atractylodis Macrocephalae extract, 2 parts of rhizome of chuanxiong extract, radix-polygoni multiflori extract 6
Part, 4 parts of papaya extractives, 20 parts of Honegsukle flower P.E, 2.5 parts of Alisma extract, 2 parts of dried orange peel extracts, 16 parts of cassia seed are sweet
1 part of careless extract, 6 parts of Ginger P.E, 11 parts of Fructus Monordicae extract, 16 parts of Lotus Leafextract, 42 parts of wax gourd extract, red rose
18 parts of rare extract, 4 parts of chrysanthemum extract, 5 parts of Fructus Rosae Normalis extract, 10 parts of Duyun Maojian Tea extract, 7 parts of decoyl salicylic acid,
0.2 part of sodium hydroxide, 50 parts of mandelic acid, 1,2- 3 parts of hexylene glycol, 1 part of pungent glycol.
The preparation method of above-mentioned soluble weight-reducing micropin, includes the following steps：
S1：Prepare Astragalus Root P.E, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, radix-polygoni multiflori extract, papaya extractives, gold and silver
Flower extract, Alisma extract, dried orange peel extracts, cassia seed, licorice, Ginger P.E, Fructus Monordicae extract, lotus leaf
Extract, wax gourd extract, red rose extract, chrysanthemum extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract, spare
S2：By weight, the Astragalus Root P.E obtained by weighing respectively in step S1, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, what
Tuber of multiflower knotweed extract, papaya extractives, Honegsukle flower P.E, Alisma extract, dried orange peel extracts, cassia seed, licorice are raw
Ginger extract, Fructus Monordicae extract, Lotus Leafextract, wax gourd extract, red rose extract, chrysanthemum extract, Rosa roxburghii Tratt extraction
Object, Duyun Maojian Tea extract are added 390 parts of deionized water, are mixed evenly, filter to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble weight-reducing micropin
Active ingredient.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble weight-reducing micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble weight-reducing micropin again.The microneedle configuration of solubility weight-reducing includes needle point 1, outsourcing
Layer 2, articulamentum 3 and substrate 4, the surrounding layer 2 are coated on 1 outside of the needle point, and 1 outside of the needle point is zigzag；It is described
Needle point 1, surrounding layer 2 are connect by the articulamentum 3 with the substrate 4；1 global shape of the needle point is cone or triangle
Shape is highly 50 microns.
Embodiment 2
The present embodiment provides a kind of soluble weight-reducing micropins, including needle point 1, and the needle point 1 includes active ingredient, according to weight
Part meter is measured, active ingredient includes：11 parts of Astragalus Root P.E, 6 parts of Rhizoma Atractylodis Macrocephalae extract, 4 parts of rhizome of chuanxiong extract, radix-polygoni multiflori extract 7
Part, 5 parts of papaya extractives, 12 parts of Honegsukle flower P.E, 3 parts of Alisma extract, 5 parts of dried orange peel extracts, 20 parts of cassia seed, Radix Glycyrrhizae
2 parts of extract, 4 parts of Ginger P.E, 12 parts of Fructus Monordicae extract, 20 parts of Lotus Leafextract, 50 parts of wax gourd extract, red rose
12 parts of extract, 6 parts of chrysanthemum extract, 8 parts of Fructus Rosae Normalis extract, 12 parts of Duyun Maojian Tea extract, 20 parts of decoyl salicylic acid, hydrogen
0.5 part of sodium oxide molybdena, 60 parts of mandelic acid, 1,2- 5 parts of hexylene glycol, 1.5 parts of pungent glycol.
The preparation method of above-mentioned soluble weight-reducing micropin, includes the following steps：
S1：Prepare Astragalus Root P.E, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, radix-polygoni multiflori extract, papaya extractives, gold and silver
Flower extract, Alisma extract, dried orange peel extracts, cassia seed, licorice, Ginger P.E, Fructus Monordicae extract, lotus leaf
Extract, wax gourd extract, red rose extract, chrysanthemum extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract are spare.
S2：By weight, the Astragalus Root P.E obtained by weighing respectively in step S1, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, what
Tuber of multiflower knotweed extract, papaya extractives, Honegsukle flower P.E, Alisma extract, dried orange peel extracts, cassia seed, licorice are raw
Ginger extract, Fructus Monordicae extract, Lotus Leafextract, wax gourd extract, red rose extract, chrysanthemum extract, Rosa roxburghii Tratt extraction
Object, Duyun Maojian Tea extract are added 360 parts of deionized water, are mixed evenly, filter to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble weight-reducing micropin
Active ingredient.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 18% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble weight-reducing micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble weight-reducing micropin again.The microneedle configuration of solubility weight-reducing includes needle point 1, outsourcing
Layer 2, articulamentum 3 and substrate 4, the surrounding layer 2 are coated on 1 outside of the needle point, and 1 outside of the needle point is zigzag；It is described
Needle point 1, surrounding layer 2 are connect by the articulamentum 3 with the substrate 4；1 global shape of the needle point is cone or triangle
Shape is highly 100 microns.
Embodiment 3
The present embodiment provides a kind of soluble weight-reducing micropins, including needle point 1, and the needle point 1 includes active ingredient, according to weight
Part meter is measured, active ingredient includes：15 parts of Astragalus Root P.E, 7 parts of Rhizoma Atractylodis Macrocephalae extract, 5 parts of rhizome of chuanxiong extract, radix-polygoni multiflori extract 10
Part, 6 parts of papaya extractives, 18 parts of Honegsukle flower P.E, 1.5 parts of Alisma extract, 6 parts of dried orange peel extracts, 15 parts of cassia seed are sweet
4 parts of careless extract, 3 parts of Ginger P.E, 15 parts of Fructus Monordicae extract, 15 parts of Lotus Leafextract, 40 parts of wax gourd extract, red rose
20 parts of rare extract, 7 parts of chrysanthemum extract, 4 parts of Fructus Rosae Normalis extract, 20 parts of Duyun Maojian Tea extract, 15 parts of decoyl salicylic acid,
2 parts of 1 part of sodium hydroxide, 70 parts of mandelic acid, 1,2- 4 parts of hexylene glycol and pungent glycol.
The preparation method of above-mentioned soluble weight-reducing micropin, includes the following steps：
S1：Prepare Astragalus Root P.E, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, radix-polygoni multiflori extract, papaya extractives, gold and silver
Flower extract, Alisma extract, dried orange peel extracts, cassia seed, licorice, Ginger P.E, Fructus Monordicae extract, lotus leaf
Extract, wax gourd extract, red rose extract, chrysanthemum extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract are spare；
S2：By weight, the Astragalus Root P.E obtained by weighing respectively in step S1, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, what
Tuber of multiflower knotweed extract, papaya extractives, Honegsukle flower P.E, Alisma extract, dried orange peel extracts, cassia seed, licorice are raw
Ginger extract, Fructus Monordicae extract, Lotus Leafextract, wax gourd extract, red rose extract, chrysanthemum extract, Rosa roxburghii Tratt extraction
Object, Duyun Maojian Tea extract are added 350 parts of deionized water, are mixed evenly, filter to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble weight-reducing micropin
Active ingredient.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 16% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm.Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble weight-reducing micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble weight-reducing micropin again.The microneedle configuration of solubility weight-reducing includes needle point 1, outsourcing
Layer 2, articulamentum 3 and substrate 4, the surrounding layer 2 are coated on 1 outside of the needle point, and 1 outside of the needle point is zigzag；It is described
Needle point 1, surrounding layer 2 are connect by the articulamentum 3 with the substrate 4；1 global shape of the needle point is cone or triangle
Shape is highly 200 microns.
Embodiment 4
The present embodiment provides a kind of soluble weight-reducing micropins, including needle point 1, and the needle point 1 includes active ingredient, according to weight
Part meter is measured, the active ingredient includes：12 parts of Astragalus Root P.E, 5 parts of Rhizoma Atractylodis Macrocephalae extract, 3.5 parts of rhizome of chuanxiong extract, the fleece-flower root carries
Take 9 parts of object, 8 parts of papaya extractives, 15 parts of Honegsukle flower P.E, 2 parts of Alisma extract, 4 parts of dried orange peel extracts, cassia seed 18
Part, 3 parts of licorice, 5 parts of Ginger P.E, 13 parts of Fructus Monordicae extract, 18 parts of Lotus Leafextract, wax gourd extract 45
Part, 15 parts of red rose extract, 5 parts of chrysanthemum extract, 6 parts of Fructus Rosae Normalis extract, 15 parts of Duyun Maojian Tea extract, decoyl water
2.5 parts of 25 parts of poplar acid, 0.8 part of sodium hydroxide, 55 parts of mandelic acid, 1,2- 6 parts of hexylene glycol and pungent glycol.
The preparation method of above-mentioned soluble weight-reducing micropin, includes the following steps：
S1：Prepare Astragalus Root P.E, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, radix-polygoni multiflori extract, papaya extractives, gold and silver
Flower extract, Alisma extract, dried orange peel extracts, cassia seed, licorice, Ginger P.E, Fructus Monordicae extract, lotus leaf
Extract, wax gourd extract, red rose extract, chrysanthemum extract, Duyun Maojian Tea extract are spare.
S2：By weight, the Astragalus Root P.E obtained by weighing respectively in step S1, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, what
Tuber of multiflower knotweed extract, papaya extractives, Honegsukle flower P.E, Alisma extract, dried orange peel extracts, cassia seed, licorice are raw
Ginger extract, Fructus Monordicae extract, Lotus Leafextract, wax gourd extract, red rose extract, chrysanthemum extract, all even high-quality green tea
Tea extraction is added 380 parts of deionized water, is mixed evenly, filters to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble weight-reducing micropin
Active ingredient.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 20% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble weight-reducing micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble weight-reducing micropin again.The microneedle configuration of solubility weight-reducing includes needle point 1, outsourcing
Layer 2, articulamentum 3 and substrate 4, the surrounding layer 2 are coated on 1 outside of the needle point, and 1 outside of the needle point is zigzag；It is described
Needle point 1, surrounding layer 2 are connect by the articulamentum 3 with the substrate 4；1 global shape of the needle point is cone or triangle
Shape is highly 400 microns.
Drink (such as effervescent tablet etc.) can also be made in the formula of micropin needle point in above-described embodiment, use the same of micropin
When combine it is oral, it is better.
The application example of product of the present invention is illustratively introduced with the product prepared in embodiment 4 below.The present invention other
Product in embodiment has the effect of similar.
For the present invention from numerous volunteers, it is 25-55 Sui to have selected age bracket, all suffers from different degrees of obesity
300 volunteers, including edema type obesity, pressure-type obesity, anemic obesity, fatigue type obesity, engorgement obesity etc.,
Wherein male to female ratio respectively accounts for half and carries out contrast test.300 volunteers are randomly divided into three groups, A groups, B groups and C groups, every group
In men and women volunteer's number it is identical, and the number of each age group is essentially identical.Volunteer in A groups uses the embodiment of the present invention
The product prepared in 4 uses weekly three times；Volunteer in B groups uses slimming drugs (commercially available), twice a day；Aspiration in C groups
Person keeps on a diet or moves.After tracking 2 years, result is as follows：
Following table is the product Piglet s colibacillosis result in the embodiment of the present invention 4：
Wherein, criterion of therapeutical effect is：Recovery from illness：Body fat is back to normal；It is effective：Body fat is reduced；Effectively：Body fat reduces apparent；Nothing
Effect：It is unchanged or more serious before and after treatment.
The product that the embodiment of the present invention 4 provides, which is can be seen that, from the experimental result in table 1 is substantially better than commercial product.With
After track six months, in A groups, the product provided using the embodiment of the present invention 4 can effectively be lost weight, and cure rate reaches
93%, the volunteer not cured is obviously improved, and it is longer to cure the time needed.In B groups, take commercially available
Slimming drugs, fat-reducing effect is apparent, but has side effect, and is easy rebound after not taking and (is no longer taken after a year and a half
With).In C groups, fat-reducing effect unobvious and need for a long time adhere to.
Soluble weight-reducing micropin provided by the invention, fat-reducing effect is apparent, efficient, and is capable of the new old of conditioning skin
Metabolism, fundamentally loses weight.During tracking, the volunteer of the product provided in the embodiment of the present invention 4, entire fat are used
Fat crosses multizone and all has improving significantly, skin more smooth exquisiteness than before, more glossy, high resilience.
In conjunction with Fig. 1, invention is further explained, and Fig. 1 is the structural schematic diagram of the microneedle configuration of soluble weight-reducing,
Including needle point 1, surrounding layer 2, articulamentum 3 and substrate 4, the surrounding layer 2 is coated on 1 outside of the needle point, 1 outside of the needle point
For zigzag.The needle point 1, surrounding layer 2 are connect by the articulamentum 3 with the substrate 4.
The needle point 1 is cone or triangle.The height of the needle point 1 is 50 microns -500 microns.Described needle point 1 etc.
Away from distribution, the distance between needle point 1 is 0.4 millimeter -0.8 millimeter.3 thickness of the articulamentum is 400 microns -600 microns.Needle point
1 base diameter is 100 microns -200 microns.
2 material of surrounding layer mainly uses hyaluronic acid in the present embodiment.Hyaluronic acid is with its unique molecular structure and reason
Change property and shows that a variety of important physiological functions, such as lubricating joint adjust the permeability of vascular wall, regulatory protein in body
Matter, Water-Electrolyte diffusion and operating, promotion, acceleration of wound healing etc..Micropin, which is pierced into skin, forms pin hole, and surrounding layer can make
Pin hole faster heals and can promote drug absorption.Other macromolecule materials, such as ethylene may be used in certain surrounding layer material
The monomer-polymer or copolymer of base pyrrolidones and its derivative, ethyl cellulose, hyaluronic acid, glucan, soluplus
(Polyvinylcaprolactame-polyvinyl acetate-polyethyleneglycol-graft copolymer), hydroxypropyl methylcellulose, methacrylic acid copolymer
Object, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides chondroitin, collagen, chitosan, branch form sediment
One or more of powder, polysaccharide polymer etc..
3 material of articulamentum is large hydrophilic molecular material, and it is fine that the large hydrophilic molecular material is selected from carbomer, methylol
One or more of the plain sodium of dimension, hydroxypropyl methyl cellulose, pectin, gelatin, alginic acid, poloxamer.Micropin when in use,
Articulamentum 3 touches the tissue fluid overflowed in the moisture and a small amount of skin of skin surface, and articulamentum 3 dissolves, needle point 1 can actively with
Substrate 4 detaches, and stays in skin, and suitable tip height enables needle point 1 completely through skin epidermis, reaches corium
Layer simultaneously releases medicine in cuticula skin below.Needle point 1 can be detached with substrate 4 and be fallen completely substantially in 15 seconds,
After needle point 1 is fallen, substrate surface is slightly smooth, is returned to gel state after the material hydrophilic of articulamentum 3 again, and the root of needle point 1
Portion is trimly fallen, and the form of needle point 1 keeps complete, does not remain the incomplete needle point of form, thus illustrates that complete needle point 1 is
It detaches with substrate 4 and to fall, rather than dissolve in water, the dissolution time of needle point 1 is much larger than the dissolution time of articulamentum 3.
The outside of needle point 1 is zigzag, and surrounding layer 2 is coated on the outside of needle point, and needle point starts to connect after surrounding layer 2 dissolves
Skin is touched, the saw tooth profile being arranged on needle point 1 increases the contact area of needle point and skin, can preferably be carried out with skin
Contact, to faster act on skin.
After needle point 1 is detached with substrate 4, needle point is stayed in the body, solve traditional soluble micropin without flexible substrate with
The fitting problem of skin and anaphylaxis injury, intradermal fracture and waste are secondary caused by avoiding patch type substrate micropin
Injure equivalent risk；The features such as it is convenient to be prepared with production, fast quantification drug release, no secondary injury.
More than, it is merely preferred embodiments of the present invention, but the protection domain invented is not limited thereto, it is any ripe
Know those skilled in the art in the technical scope disclosed by the present invention, the change or replacement that can be readily occurred in should all be contained
Lid is within protection scope of the present invention.Therefore, the scope of protection of the invention shall be subject to the scope of protection specified in the patent claim.
Claims (10)
1. a kind of soluble weight-reducing micropin, including needle point (1), which is characterized in that the needle point (1) includes active ingredient, according to
Parts by weight meter, the active ingredient include：
10-15 parts of Astragalus Root P.E, 3-8 parts of Rhizoma Atractylodis Macrocephalae extract, 2-5 parts of rhizome of chuanxiong extract, 5-12 parts of radix-polygoni multiflori extract, pawpaw
4-10 parts of extract, 10-20 parts of Honegsukle flower P.E, 1-3 parts of Alisma extract, 2-6 parts of dried orange peel extracts, cassia seed 15-20
Part, 1-4 parts of licorice, 3-6 parts of Ginger P.E, 10-15 parts of Fructus Monordicae extract, 15-20 parts of Lotus Leafextract, wax gourd
40-50 parts of extract, 10-20 parts of red rose extract, 2-8 parts of chrysanthemum extract, 3-10 parts of Fructus Rosae Normalis extract.
2. soluble weight-reducing micropin according to claim 1, which is characterized in that in parts by weight, the active ingredient
Including：11-13 parts of Astragalus Root P.E, 4-6 parts of Rhizoma Atractylodis Macrocephalae extract, 3-4 parts of rhizome of chuanxiong extract, 6-10 parts of radix-polygoni multiflori extract, wood
6-8 parts of melon extract, 15-18 parts of Honegsukle flower P.E, 1-3 parts of Alisma extract, 3-5 parts of dried orange peel extracts, cassia seed 16-18
Part, 2-3 parts of licorice, 4-5 parts of Ginger P.E, 11-14 parts of Fructus Monordicae extract, 16-18 parts of Lotus Leafextract, wax gourd
42-49 parts of extract, 14-18 parts of red rose extract, 4-6 parts of chrysanthemum extract, 4-8 parts of Fructus Rosae Normalis extract.
3. soluble weight-reducing micropin according to claim 2, which is characterized in that in parts by weight, the active ingredient
Including：12 parts of Astragalus Root P.E, 5 parts of Rhizoma Atractylodis Macrocephalae extract, 3.5 parts of rhizome of chuanxiong extract, 9 parts of radix-polygoni multiflori extract, papaya extractives 8
Part, 15 parts of Honegsukle flower P.E, 2 parts of Alisma extract, 4 parts of dried orange peel extracts, 18 parts of cassia seed, 3 parts of licorice, ginger
5 parts of extract, 13 parts of Fructus Monordicae extract, 18 parts of Lotus Leafextract, 45 parts of wax gourd extract, 15 parts of red rose extract, chrysanthemum
5 parts of flower extract, 6 parts of Fructus Rosae Normalis extract.
4. soluble weight-reducing micropin according to any one of claim 1-3, which is characterized in that in parts by weight, also
Including 8-22 parts of Duyun Maojian Tea extract.
5. soluble weight-reducing micropin according to any one of claim 1-3, which is characterized in that further include decoyl salicylic acid
7-30 parts, 0.2-1.8 parts of sodium hydroxide, 50-75 parts of mandelic acid, 1,2- 3-8 parts of hexylene glycol, pungent glycol 1-3 parts.
6. soluble weight-reducing micropin according to any one of claim 1-3, which is characterized in that further include surrounding layer, group
It is selected from the monomer-polymer or copolymer of vinyl pyrrolidone and its derivative, ethyl cellulose, thoroughly at the material of surrounding layer
Bright matter acid, glucan, Polyvinylcaprolactame-polyvinyl acetate-polyethyleneglycol-graft copolymer, hydroxypropyl methylcellulose, first
Base acrylic copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides chondroitin, collagen, shell
It is one or more in glycan, amylopectin, polysaccharide polymer.
7. soluble weight-reducing micropin according to claim 6, which is characterized in that the material for forming surrounding layer is hyalomitome
The mass concentration of acid, the hyaluronic acid is 15%~20%.
8. a kind of preparation method of soluble weight-reducing micropin described in claim 1, which is characterized in that include the following steps：
S1：Prepare Astragalus Root P.E, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, radix-polygoni multiflori extract, papaya extractives, honeysuckle carries
Take object, Alisma extract, dried orange peel extracts, cassia seed, licorice, Ginger P.E, Fructus Monordicae extract, lotus leaf extraction
Object, wax gourd extract, red rose extract, chrysanthemum extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract are spare；
S2：By weight, the Astragalus Root P.E of gained in step S1, Rhizoma Atractylodis Macrocephalae extract, rhizome of chuanxiong extract, the fleece-flower root are weighed respectively
Extract, papaya extractives, Honegsukle flower P.E, Alisma extract, dried orange peel extracts, cassia seed, licorice, ginger carry
Take object, Fructus Monordicae extract, Lotus Leafextract, wax gourd extract, red rose extract, chrysanthemum extract, Fructus Rosae Normalis extract, all
Even high-quality green tea tea extraction is added 300-400 parts of deionized water, is mixed evenly, filters to take filtrate；
S3：Claim decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol adds it to step
It in filtrate described in rapid S2, is uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form the effective of soluble weight-reducing micropin
Ingredient；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made；
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken out, it is suitable
Hour hands are rotated by 90 ° placement, are rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, it is horizontal under 1000rpm again
Centrifugation 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble weight-reducing micropin in step S3 is added in step S5 in the mold containing surrounding layer,
It dries, demoulds after dry up to soluble weight-reducing micropin again.
9. a kind of microneedle configuration of soluble weight-reducing, which is characterized in that the microneedle configuration of the soluble weight-reducing includes needle point
(1), surrounding layer (2), articulamentum (3) and substrate (4), the surrounding layer (2) are coated on the outside of the needle point (1), the needle point
(1) outside is zigzag；The needle point (1), surrounding layer (2) are connect by the articulamentum (3) with the substrate (4).
10. the microneedle configuration of soluble weight-reducing according to claim 9, which is characterized in that the height of the needle point (1) is
50-500 microns.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846785A (en) * | 2019-03-20 | 2019-06-07 | 广州纳丽生物科技有限公司 | A kind of solvable micropin and preparation method thereof with spot-removing function |
| CN110974891A (en) * | 2019-12-23 | 2020-04-10 | 广州新济薇娜生物科技有限公司 | Microneedle patch for losing weight and preparation method thereof |
| CN112316292A (en) * | 2020-07-26 | 2021-02-05 | 浙江工业大学 | Bionic microneedle patch for transdermal drug delivery |
-
2018
- 2018-02-28 CN CN201810167836.9A patent/CN108310338A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846785A (en) * | 2019-03-20 | 2019-06-07 | 广州纳丽生物科技有限公司 | A kind of solvable micropin and preparation method thereof with spot-removing function |
| CN110974891A (en) * | 2019-12-23 | 2020-04-10 | 广州新济薇娜生物科技有限公司 | Microneedle patch for losing weight and preparation method thereof |
| CN110974891B (en) * | 2019-12-23 | 2022-10-04 | 广州新济薇娜生物科技有限公司 | Microneedle patch for losing weight and preparation method thereof |
| CN112316292A (en) * | 2020-07-26 | 2021-02-05 | 浙江工业大学 | Bionic microneedle patch for transdermal drug delivery |
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