CN108236758A - A kind of solubility anti-wrinkle micropin and preparation method thereof - Google Patents
A kind of solubility anti-wrinkle micropin and preparation method thereof Download PDFInfo
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- CN108236758A CN108236758A CN201810166379.1A CN201810166379A CN108236758A CN 108236758 A CN108236758 A CN 108236758A CN 201810166379 A CN201810166379 A CN 201810166379A CN 108236758 A CN108236758 A CN 108236758A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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Abstract
The invention discloses a kind of soluble anti-wrinkle micropins, and including needle point (1), the needle point (1) includes active ingredient, and in parts by weight, the active ingredient includes：7 10 parts of gadol extract, 68 parts of siberian Ginseng P.E, 57 parts of Herb Gynostemmae Pentaphylli extract, 57 parts of Fructus Monordicae extract, 58 parts of Borneolum Syntheticum extract, 5 20 parts of rose extract, 10 20 parts of Notogineng Extract, 5 10 parts of Salvia root P.E, 10 20 parts of Scutellaria baicalensis extract, 20 30 parts of angelica extract, 38 parts of Rhizoma Smilacis Glabrae extract, 35 parts of dandelion extract, 25 parts of Herba Lysimachiae foenumgraeci extract, 25 parts of Angelica Dahurica extract.This micropin anti-wrinkle is with obvious effects.
Description
Technical field
The invention belongs to beauty appliance fields, and in particular to a kind of solubility anti-wrinkle micropin and preparation method thereof.
Background technology
Wrinkle refers to that skin is influenced by external environment, forms free free radical, and free radical destroys normal cell membrane tissue
Interior collagen, active material, oxidative cell and the small microgroove, the wrinkle that are formed.Wrinkle occurs gradually.The sequence of appearance is general
It is forehead, upper palpebra inferior, paropia, ear proparea, cheek, neck, lower chin, mouth week.Facial wrinkles are divided into atrophy wrinkle and loose wrinkle
Line two types.Atrophy wrinkle refers to appear in the wrinkle on thin, easy jackknifing and dry skin, and such as circumference of eyes, those are countless
Tiny wrinkle；Loose wrinkle refers to appear in the wrinkle in Oily, and quantity is few, and texture is close and deep, such as forehead, lip week
It encloses, the latest find that the wrinkle wrinkle at lower jaw is formed.Existing anti-wrinkle product mainly has medicine shaping and beauty, anti-wrinkle frost, dispels
Lotion of wrinkling etc., however also there are many disadvantages for existing anti-wrinkle product, traditional Chinese medicine shaping and beauty is although quick, but expense
Costliness, and the material of anti-wrinkle and preparation still remain defect, easily bring complication to consumer；And existing anti-wrinkle is white, dispels
Wrinkle lotion, since skin barrier acts on, functional component tends not to effectively absorb, and effect is limited.
Invention content
The main object of the present invention is to provide for a kind of soluble anti-wrinkle micropin and preparation method thereof, to solve existing dispel
The problem of product anti-wrinkle effect of wrinkling is bad.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of solubility anti-wrinkle micropin, including needle point 1, the needle point 1 includes active ingredient, in parts by weight, described
Active ingredient includes：
7-10 parts of gadol extract, 6-8 parts of siberian Ginseng P.E, 5-7 parts of Herb Gynostemmae Pentaphylli extract, Fructus Monordicae extract 5-
7 parts, 5-8 parts of Borneolum Syntheticum extract, 5-20 parts of rose extract, 10-20 parts of Notogineng Extract, 5-10 parts of Salvia root P.E, scutellaria
10-20 parts of extract, 20-30 parts of angelica extract, 3-8 parts of Rhizoma Smilacis Glabrae extract, 3-5 parts of dandelion extract, lavender carries
Take 2-5 parts of object, 2-5 parts of Angelica Dahurica extract.
Preferably, in parts by weight, the active ingredient includes：8-9 parts of gadol extract, siberian Ginseng P.E 6-
8 parts, 5-7 parts of Herb Gynostemmae Pentaphylli extract, 5-7 parts of Fructus Monordicae extract, 5-8 parts of Borneolum Syntheticum extract, 10-15 parts of rose extract, three
Seven 12-15 parts of extracts, 6-8 parts of Salvia root P.E, 12-18 parts of Scutellaria baicalensis extract, 24-28 parts of angelica extract, smilax carries
Take 5-6 parts of object, 3-5 parts of dandelion extract, 2-5 parts of Herba Lysimachiae foenumgraeci extract, 2-5 parts of Angelica Dahurica extract.
Preferably, in parts by weight, the active ingredient includes：8.5 parts of gadol extract, siberian Ginseng P.E 7
Part, 6 parts of Herb Gynostemmae Pentaphylli extract, 6 parts of Fructus Monordicae extract, 7 parts of Borneolum Syntheticum extract, 12 parts of rose extract, Notogineng Extract 13
Part, 7 parts of Salvia root P.E, 15 parts of Scutellaria baicalensis extract, 25 parts of angelica extract, 5.5 parts of Rhizoma Smilacis Glabrae extract, dandelion extract
4 parts, 4 parts of Herba Lysimachiae foenumgraeci extract, 4 parts of Angelica Dahurica extract
Preferably, in parts by weight, 8-22 parts of Duyun Maojian Tea extract is further included.
Preferably, further include 7-30 parts of decoyl salicylic acid, 0.2-1.8 parts of sodium hydroxide, 50-75 parts of mandelic acid, 1,2- oneself
3-8 parts of glycol, pungent glycol 1-3 parts.
Preferably, surrounding layer is further included, the material for forming surrounding layer is selected from the list of vinyl pyrrolidone and its derivative
Body polymer or copolymer, ethyl cellulose, hyaluronic acid, glucan, soluplus, hydroxypropyl methylcellulose, methacrylic acid
Copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides chondroitin, collagen, chitosan, branch
It is one or more in starch, polysaccharide polymer.
Preferably, form the material of surrounding layer as hyaluronic acid, the mass concentration of the hyaluronic acid for 15%~
20%.
A kind of preparation method of soluble anti-wrinkle micropin described in claim 1, includes the following steps：
S1：Prepare gadol extract, siberian Ginseng P.E, Herb Gynostemmae Pentaphylli extract, Fructus Monordicae extract, borneol extraction
Object, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, angelica extract, Rhizoma Smilacis Glabrae extract, dandelion
Extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract are spare；
S2：By weight, the gadol extract of gained in step S1, siberian Ginseng P.E are weighed respectively, and gynostemma pentaphylla carries
Take object, Fructus Monordicae extract, Borneolum Syntheticum extract, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, Radix Angelicae Sinensis
Extract, Rhizoma Smilacis Glabrae extract, dandelion extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract add
Enter 300-400 parts of deionized water, be mixed evenly, filter to take filtrate；
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, less than 40 DEG C rotary evaporations remove moisture, form soluble anti-wrinkle micropin
Active ingredient；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made；
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal minute；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble anti-wrinkle micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble anti-wrinkle micropin again.
A kind of microneedle configuration of solubility anti-wrinkle, the microneedle configuration of the solubility anti-wrinkle include needle point 1, needle base 2, institute
It states needle point 1 to connect with the needle base 2,2 outer layer of needle base is provided with surrounding layer 3；The needle point 1 is cone or triangle.
Preferably, the height of the needle point 1 is 50-500 microns.
Compared with prior art, soluble anti-wrinkle micropin of the present invention and preparation method thereof at least has the advantages that：
1) active ingredient in the present invention, is selected by the height to various anti-wrinkle drugs and carries out optimal combination, so as to
The dosage and toxic side effect of each drug are reduced, expands its safe range and use scope.
2) gadol extract in active ingredient of the present invention, siberian Ginseng P.E, Herb Gynostemmae Pentaphylli extract, Siraitia grosvenorii extraction
Object, Borneolum Syntheticum extract, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, angelica extract, smilax carry
Object is taken, dandelion extract, Herba Lysimachiae foenumgraeci extract, the Chinese medical extracts such as Angelica Dahurica extract and Duyun Maojian Tea extract can
Improve the metabolism of skin while anti-wrinkle, improve the microenvironment around wrinkle, fundamentally anti-wrinkle.
3) soluble anti-wrinkle micropin provided by the invention has biodegradable, can be completely dissolved or drop in skin
Solution.Prepare surrounding layer using hyaluronic acid, on the one hand can protect active ingredient, avoid active ingredient contact external environment and by
Oxidation is rotten etc.；On the other hand, hyaluronic acid can dissolve rapidly, discharge the active ingredient of the inside, and the solubility anti-wrinkle is micro-
Needle set has certain slow release effect.
4) soluble anti-wrinkle micropin provided by the invention can rapidly dissolve inside skin, reach at wrinkle, with taking orally
Conditioning is compared, and can substantially shorten treatment time, and drug is avoided to absorb the content of attenuating active ingredient or because ensureing through gastrointestinal disturbances
The content of active ingredient and the dosage that must not be not added with big active ingredient improve cost；Compared with being directly coated with skin condition, this hair
The soluble anti-wrinkle micropin of bright offer can be reached directly at wrinkle, avoid skin to the blocking of active ingredient and because of skin
Absorption is slower, and active ingredient is failed by Oxidative demage.
5) soluble anti-wrinkle micropin provided by the invention can be completely dissolved so that active ingredient free of losses improves effective
The utilization rate of ingredient, is directly applied at tool wrinkle, directly improves the metabolism at wrinkle, efficient, at low cost, energy
Active ingredient is enough avoided to cause unnecessary stimulation to other positions.
6) anti-wrinkle micropin provided by the invention is readily produced, transports and stores, and reduces cost.
7) anti-wrinkle micropin provided by the invention coordinates corresponding instrument or without instrument, be in can Self-operating, nothing
It need to go to beauty parlor.Not only safety, but it is time saving, economical.
Description of the drawings
Fig. 1 is the structure diagram of the soluble anti-wrinkle micropin of the present invention.
Specific embodiment
The invention will be further described with reference to the accompanying drawings and examples, and following embodiment is descriptive, is not
Limited, it is impossible to protection scope of the present invention is limited with this.
The purpose, technical scheme and advantage for making the embodiment of the present invention are clearer, below in conjunction in the embodiment of the present invention
Attached drawing, the technical solution in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is this
Invention part of the embodiment, instead of all the embodiments.Embodiments of the present invention, which are generally described and illustrated herein in the accompanying drawings
Component can arrange and design with a variety of different configurations.Therefore, the implementation of the present invention to providing in the accompanying drawings below
The detailed description of example is not intended to limit the range of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
The embodiment of the present invention is described below in detail, the example of the embodiment is shown in the drawings, wherein from beginning to end
Same or similar label represents same or similar element or the element with same or like function.Below with reference to attached
The embodiment of figure description is exemplary, it is intended to for explaining the present invention, and is not considered as limiting the invention.
Extract in the present invention：Refer to a kind of by impregnating or being mixed in solvent by the substance of extract to be obtained
The solution for extracting and obtaining.Extraction process can carry out with the help of the suitable solvent of selection, such as：Water, ethyl alcohol, ethanol/water
Mixture, methanol, propyl alcohol, butanol, chloroform, acetone or other organic solvents, and pass through isolation, diafiltration, decoction, counter-current extraction,
Ultrasonic wave, microwave, supercritical fluid extraction method obtain extract, extract is further concentrated by evaporation, and obtains medicinal extract and dry
Dry extract.
In the formula of the present invention, the characteristics of each component and function is as follows：
Rhodiola root：Qi and activate blood circulation, antiasthmatic-antitussive, anti-aging.
Wilsonii：Damp-clearing pain-relieving, promoting blood circulation arteries and veins, helps sleep at strengthening the bones and muscles.
Gynostemma pentaphylla：It is stomach strengthening and digestion promoting, relieving cough and reducing sputum, clearing heat and detoxicating.
Siraitia grosvenorii：Removing heat from the lung and relieving sorethroat, relaxes bowel at preventing phlegm from forming and stopping coughing.
Borneol：For red eye, swell pain, larynx numbness aphtha, for sore swell and ache curative is not held back after bursting.
Rose：It can chill out, balance endocrine, replenishing blood and vital energy, U.S. face skin care plays the role of conditioning and can to liver and stomach
Dispelling fatigue improves constitution, and the fragrant taste of rose tea is quiet and tastefully laid out, can make us chilling out, relieve depression.
Radix Notoginseng：Strengthening by means of tonics, anti-aging, reducing blood lipid, blood pressure lowering, improves body's immunity etc. at antifatigue, resist oxygen lack.
Radix Salviae Miltiorrhizae：For chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea warp
It closes, sore swell and ache curative.
Scutellaria：There are heat-clearing and damp-drying drug, cool blood tocolysis, detoxicating functions.
Radix Angelicae Sinensis：It relaxes bowel, is promoting blood circulation and removing blood stasis, menstruction regulating and pain relieving.
Smilax：Removing toxic substances, analgesia, diuresis.
Dandelion：Clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia.
Lavender：Tranquilizing soporific, antibacterial anti-inflammatory, spasmolysis and analgesia.
The root of Dahurain angelica：Get rid of illness the functions such as dehumidifying, apocenosis myogenic, promoting blood circulation and stopping pain.
All equal high-quality green tea tea extraction：Contain abundant protein, amino acid, alkaloid, tea polyphenols, sugared point, organic acid, virtue
Studies of The Aromatic Substances and vitamin A, B1, B2, C, K, P, PP etc. and water-soluble minerals.
Other materials or product in the present invention, be it is commercially available, unless otherwise indicated.
The present invention provides a kind of soluble anti-wrinkle micropin, and including needle point 1, the needle point 1 includes active ingredient, according to weight
Part meter, active ingredient include：7-10 parts of gadol extract, 6-8 parts of siberian Ginseng P.E, 5-7 parts of Herb Gynostemmae Pentaphylli extract, arhat
5-7 parts of berry extract, 5-8 parts of Borneolum Syntheticum extract, 5-20 parts of rose extract, 10-20 parts of Notogineng Extract, Salvia root P.E
5-10 parts, 10-20 parts of Scutellaria baicalensis extract, 20-30 parts of angelica extract, 3-8 parts of Rhizoma Smilacis Glabrae extract, dandelion extract 3-5
Part, 2-5 parts of Herba Lysimachiae foenumgraeci extract, 2-5 parts of Angelica Dahurica extract, 8-22 parts of Duyun Maojian Tea extract, decoyl salicylic acid 7-30
Part, 0.2-1.8 parts of sodium hydroxide, 50-75 parts of mandelic acid, 1,2- 3-8 parts of hexylene glycol, pungent glycol 1-3 parts.
Solubility anti-wrinkle micropin provided by the invention further includes surrounding layer.Surrounding layer mainly uses hyaluronic acid.Hyalomitome
Acid shows a variety of important physiological functions with its unique molecular structure and physicochemical property in body, and such as lubricating joint is adjusted
Save the permeability of vascular wall, regulatory protein matter, Water-Electrolyte diffusion and operating, promotion, acceleration of wound healing etc..Certain surrounding layer
Other high molecular materials may be used, such as vinyl pyrrolidone and its monomer-polymer or copolymer of derivative, ethyl is fine
Dimension element, hyaluronic acid, glucan, soluplus (Polyvinylcaprolactames-polyvinyl acetate-polyethylene glycol graft copolymerization
Object), hydroxypropyl methylcellulose, methacrylic acid copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides
One or more of chondroitin, collagen, chitosan, amylopectin, polysaccharide polymer etc..
The preparation method of above-mentioned solubility anti-wrinkle micropin, mainly includes the following steps that：
S1：Prepare gadol extract, siberian Ginseng P.E, Herb Gynostemmae Pentaphylli extract, Fructus Monordicae extract, borneol extraction
Object, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, angelica extract, Rhizoma Smilacis Glabrae extract, dandelion
Extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract are spare.
S2：By weight, the gadol extract of gained in step S1, siberian Ginseng P.E are weighed respectively, and gynostemma pentaphylla carries
Take object, Fructus Monordicae extract, Borneolum Syntheticum extract, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, Radix Angelicae Sinensis
Extract, Rhizoma Smilacis Glabrae extract, dandelion extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract add
Enter 300-400 parts of deionized water, be mixed evenly, filter to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, less than 40 DEG C rotary evaporations remove moisture, form soluble anti-wrinkle micropin
Active ingredient.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble anti-wrinkle micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble anti-wrinkle micropin again.
The microneedle configuration of the solubility anti-wrinkle includes needle point 1, needle base 2, and the needle point 1 is connect with the needle base 2, institute
It states 2 outer layer of needle base and is provided with surrounding layer 3；The needle point 1 is cone or triangle.The height of the needle point 1 is micro- for 50-500
Rice.
Embodiment 1
The present embodiment provides a kind of soluble anti-wrinkle micropins, and including needle point 1, the needle point 1 includes active ingredient, according to weight
Part meter is measured, active ingredient includes：7 parts of gadol extract, 6 parts of siberian Ginseng P.E, 5.5 parts of Herb Gynostemmae Pentaphylli extract, Siraitia grosvenorii
6 parts of extract, 7 parts of Borneolum Syntheticum extract, 6 parts of rose extract, 20 parts of Notogineng Extract, 8 parts of Salvia root P.E, Scutellaria baicalensis extract
18 parts, 28 parts of angelica extract, 8 parts of Rhizoma Smilacis Glabrae extract, 3 parts of dandelion extract, 5 parts of Herba Lysimachiae foenumgraeci extract, root of Dahurain angelica extraction
2 parts of object, 10 parts of Duyun Maojian Tea extract, 7 parts of decoyl salicylic acid, 0.2 part of sodium hydroxide, 50 parts of mandelic acid, 1,2- hexylene glycol
3 parts, pungent 1 part of glycol.
The preparation method of above-mentioned solubility anti-wrinkle micropin, includes the following steps：
S1：Prepare gadol extract, siberian Ginseng P.E, Herb Gynostemmae Pentaphylli extract, Fructus Monordicae extract, borneol extraction
Object, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, angelica extract, Rhizoma Smilacis Glabrae extract, dandelion
Extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract are spare.
S2：By weight, the gadol extract of gained in step S1, siberian Ginseng P.E are weighed respectively, and gynostemma pentaphylla carries
Take object, Fructus Monordicae extract, Borneolum Syntheticum extract, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, Radix Angelicae Sinensis
Extract, Rhizoma Smilacis Glabrae extract, dandelion extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract add
Enter 300 parts of deionized water, be mixed evenly, filter to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, less than 40 DEG C rotary evaporations remove moisture, form soluble anti-wrinkle micropin
Active ingredient.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble anti-wrinkle micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble anti-wrinkle micropin again.The micro- needle construction of the solubility anti-wrinkle includes needle point 1, needle base
2, the needle point 1 is connect with the needle base 2, and 2 outer layer of needle base is provided with surrounding layer 3；The needle point 1 is cone or triangle
Shape is highly 50 microns.Micropin is connect by articulamentum 4 with external device.
Embodiment 2
The present embodiment provides a kind of soluble anti-wrinkle micropins, and including needle point 1, the needle point 1 includes active ingredient, according to weight
Part meter is measured, active ingredient includes：10 parts of gadol extract, 8 parts of siberian Ginseng P.E, 7 parts of Herb Gynostemmae Pentaphylli extract, Siraitia grosvenorii carries
Take 7 parts of object, 8 parts of Borneolum Syntheticum extract, 20 parts of rose extract, 10 parts of Notogineng Extract, 5 parts of Salvia root P.E, Scutellaria baicalensis extract
20 parts, 30 parts of angelica extract, 7 parts of Rhizoma Smilacis Glabrae extract, 5 parts of dandelion extract, 2 parts of Herba Lysimachiae foenumgraeci extract, root of Dahurain angelica extraction
4 parts of object, 12 parts of Duyun Maojian Tea extract, 20 parts of decoyl salicylic acid, 0.5 part of sodium hydroxide, 60 parts of mandelic acid, 1,2- oneself two
5 parts of alcohol, pungent 1.5 parts of glycol.
The preparation method of above-mentioned solubility anti-wrinkle micropin, includes the following steps：
S1：Prepare gadol extract, siberian Ginseng P.E, Herb Gynostemmae Pentaphylli extract, Fructus Monordicae extract, borneol extraction
Object, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, angelica extract, Rhizoma Smilacis Glabrae extract, dandelion
Extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract are spare.
S2：By weight, the gadol extract of gained in step S1, siberian Ginseng P.E are weighed respectively, and gynostemma pentaphylla carries
Take object, Fructus Monordicae extract, Borneolum Syntheticum extract, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, Radix Angelicae Sinensis
Extract, Rhizoma Smilacis Glabrae extract, dandelion extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract add
Enter 350 parts of deionized water, be mixed evenly, filter to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, less than 40 DEG C rotary evaporations remove moisture, form soluble anti-wrinkle micropin
Active ingredient.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 18% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble anti-wrinkle micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble anti-wrinkle micropin again.The microneedle configuration of the solubility anti-wrinkle includes needle point 1, needle base
2, the needle point 1 is connect with the needle base 2, and 2 outer layer of needle base is provided with surrounding layer 3；The needle point 1 is cone or triangle
Shape is highly 100 microns.Micropin is connect by articulamentum 4 with external device.
Embodiment 3
The present embodiment provides a kind of soluble anti-wrinkle micropins, and including needle point 1, the needle point 1 includes active ingredient, according to weight
Part meter is measured, active ingredient includes：8 parts of gadol extract, 7 parts of siberian Ginseng P.E, 5 parts of Herb Gynostemmae Pentaphylli extract, Siraitia grosvenorii carries
Take 5 parts of object, 5 parts of Borneolum Syntheticum extract, 15 parts of rose extract, 16 parts of Notogineng Extract, 10 parts of Salvia root P.E, Scutellaria baicalensis extract
10 parts, 20 parts of angelica extract, 4 parts of Rhizoma Smilacis Glabrae extract, 4 parts of dandelion extract, 4 parts of Herba Lysimachiae foenumgraeci extract, root of Dahurain angelica extraction
4 parts of object, 20 parts of Duyun Maojian Tea extract, 15 parts of decoyl salicylic acid, 1 part of sodium hydroxide, 70 parts of mandelic acid, 1,2- hexylene glycol 4
2 parts of part and pungent glycol.
The preparation method of above-mentioned solubility anti-wrinkle micropin, includes the following steps：
S1：Prepare gadol extract, siberian Ginseng P.E, Herb Gynostemmae Pentaphylli extract, Fructus Monordicae extract, borneol extraction
Object, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, angelica extract, Rhizoma Smilacis Glabrae extract, dandelion
Extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract are spare.
S2：By weight, the gadol extract of gained in step S1, siberian Ginseng P.E are weighed respectively, and gynostemma pentaphylla carries
Take object, Fructus Monordicae extract, Borneolum Syntheticum extract, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, Radix Angelicae Sinensis
Extract, Rhizoma Smilacis Glabrae extract, dandelion extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract add
Enter 380 parts of deionized water, be mixed evenly, filter to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, less than 40 DEG C rotary evaporations remove moisture, form soluble anti-wrinkle micropin
Active ingredient.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 16% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble anti-wrinkle micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble anti-wrinkle micropin again.The microneedle configuration of the solubility anti-wrinkle includes needle point 1, needle base
2, the needle point 1 is connect with the needle base 2, and 2 outer layer of needle base is provided with surrounding layer 3；The needle point 1 is cone or triangle
Shape is highly 200 microns.Micropin is connect by articulamentum 4 with external device.
Embodiment 4
The present embodiment provides a kind of soluble anti-wrinkle micropins, and including needle point 1, the needle point 1 includes active ingredient, according to weight
Part meter is measured, the active ingredient includes：8.5 parts of gadol extract, 7 parts of siberian Ginseng P.E, 6 parts of Herb Gynostemmae Pentaphylli extract, sieve
6 parts of Chinese berry extract, 7 parts of Borneolum Syntheticum extract, 12 parts of rose extract, 13 parts of Notogineng Extract, 7 parts of Salvia root P.E, scutellaria
15 parts of extract, 25 parts of angelica extract, 5.5 parts of Rhizoma Smilacis Glabrae extract, 4 parts of dandelion extract, 4 parts of Herba Lysimachiae foenumgraeci extract,
4 parts of Angelica Dahurica extract, 15 parts of Duyun Maojian Tea extract, 25 parts of decoyl salicylic acid, 0.8 part of sodium hydroxide, 55 parts of mandelic acid,
2.5 parts of 1,2- 6 parts of hexylene glycol and pungent glycol.
The preparation method of above-mentioned solubility anti-wrinkle micropin, includes the following steps：
S1：Prepare gadol extract, siberian Ginseng P.E, Herb Gynostemmae Pentaphylli extract, Fructus Monordicae extract, borneol extraction
Object, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, angelica extract, Rhizoma Smilacis Glabrae extract, dandelion
Extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract are spare.
S2：By weight, the gadol extract of gained in step S1, siberian Ginseng P.E are weighed respectively, and gynostemma pentaphylla carries
Take object, Fructus Monordicae extract, Borneolum Syntheticum extract, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, Radix Angelicae Sinensis
Extract, Rhizoma Smilacis Glabrae extract, dandelion extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract add
Enter 320 parts of deionized water, be mixed evenly, filter to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, less than 40 DEG C rotary evaporations remove moisture, form soluble anti-wrinkle micropin
Active ingredient.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 20% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble anti-wrinkle micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble anti-wrinkle micropin again.The microneedle configuration of the solubility anti-wrinkle includes needle point 1, needle base
2, the needle point 1 is connect with the needle base 2, and 2 outer layer of needle base is provided with surrounding layer 3；The needle point 1 is cone or triangle
Shape is highly 400 microns.Micropin is connect by articulamentum 4 with external device.
The application example of product of the present invention is illustratively introduced with the product prepared in embodiment 4 below.The present invention other
Product in embodiment has similar effect.
For the present invention from numerous volunteers, it is 25-55 Sui to have selected age bracket, suffers from 300 volunteers wrinkly,
Middle men and women is fifty-fifty.300 volunteers are randomly divided into three groups, A groups, B groups and C groups, and the number of each age group is essentially identical.A
Volunteer in group is using the product prepared in the embodiment of the present invention 4, daily using primary；Volunteer in B groups uses anti-wrinkle
Drug (commercially available), takes, twice a day daily；Volunteer in C groups is by moving anti-wrinkle.After tracking 1 year, result is such as
Under：
Following table is the product Piglet s colibacillosis result in the embodiment of the present invention 4：
Wherein, criterion of therapeutical effect is：Recovery from illness：Wrinkle is dispelled completely；It is effective：Anti-wrinkle rate is up to more than 50%；Effectively：Anti-wrinkle rate reaches
More than 10%；In vain：It is unchanged before and after treatment.
The product that can be seen that the offer of the embodiment of the present invention 4 from the experimental result in table 1 is substantially better than commercial product.With
After track 1 year, in A groups, the product that is provided using the embodiment of the present invention 4 can effective anti-wrinkle, cure rate reached 93%,
The volunteer not cured, is obviously improved, and it is longer to cure the time needed.In B groups, commercially available anti-wrinkle is used
Medicine, anti-wrinkle effect are not apparent.In C groups, by move anti-wrinkle almost without effect.
Solubility anti-wrinkle micropin provided by the invention, anti-wrinkle is with obvious effects, efficient, and can improve new at wrinkle
Old metabolism so that skin restores normal physiological function, fundamentally anti-wrinkle.During tracking, the embodiment of the present invention 4 is used
The volunteer of the product of middle offer restores very good, skin high resilience at wrinkle.
As shown in Figure 1, the structure diagram for soluble anti-wrinkle micropin of the invention, including needle point 1, needle base 2, the needle point
1 is set on needle base 2, and 2 outer layer of needle base is provided with surrounding layer 3.The needle point 1 is cone or triangle.The needle point 1
Height be 300 microns -500 microns.Needle point 1 is equally spaced, and the distance between needle point 1 is 0.4 millimeter -0.8 millimeter.Needle point 1
Base diameter be 100 microns -200 microns.2 height of needle base is 100 microns -200 microns.
3 material of surrounding layer mainly uses hyaluronic acid in the present embodiment.Hyaluronic acid is with its unique molecular structure and reason
Change property and show a variety of important physiological functions in body, such as lubricating joint adjusts the permeability of vascular wall, regulatory protein
Matter, Water-Electrolyte diffusion and operating, promotion, acceleration of wound healing etc..Micropin, which is pierced into skin, forms pin hole, and surrounding layer can make
Pin hole faster heals and can promote drug absorption.Other macromolecule materials, such as ethylene may be used in certain 3 material of surrounding layer
The monomer-polymer or copolymer of base pyrrolidones and its derivative, ethyl cellulose, hyaluronic acid, glucan, soluplus
(Polyvinylcaprolactame-polyvinyl acetate-polyethyleneglycol-graft copolymer), hydroxypropyl methylcellulose, methacrylic acid copolymer
Object, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides chondroitin, collagen, chitosan, branch form sediment
One or more of powder, polysaccharide polymer etc..
Needle point 1 is set on needle base 2, and after micropin is pierced into skin, needle point 1 is pierced into deep skin, and needle base 2 stays in shallow-layer
Skin.Since needle point 1 is set in for cone or triangle and needle point 1 on needle base 2, when extracting micropin, needle point 1 and
Needle base 2 detaches, and needle point 1, which is stayed in skin, to be continued to play drug effect, and needle base 2 is extracted.Surrounding layer 3 promotes pin hole healing.
More than, it is merely preferred embodiments of the present invention, but the protection domain invented is not limited thereto, it is any ripe
Know those skilled in the art in the technical scope disclosed by the present invention, the change or replacement that can be readily occurred in should all be contained
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be subject to the protection domain of claims.
Claims (10)
1. a kind of solubility anti-wrinkle micropin, including needle point (1), which is characterized in that the needle point (1) includes active ingredient, according to
Parts by weight meter, the active ingredient include：
7-10 parts of gadol extract, 6-8 parts of siberian Ginseng P.E, 5-7 parts of Herb Gynostemmae Pentaphylli extract, 5-7 parts of Fructus Monordicae extract,
5-8 parts of Borneolum Syntheticum extract, 5-20 parts of rose extract, 10-20 parts of Notogineng Extract, 5-10 parts of Salvia root P.E, scutellaria extraction
10-20 parts of object, 20-30 parts of angelica extract, 3-8 parts of Rhizoma Smilacis Glabrae extract, 3-5 parts of dandelion extract, Herba Lysimachiae foenumgraeci extract
2-5 parts, 2-5 parts of Angelica Dahurica extract.
2. solubility anti-wrinkle micropin according to claim 1, which is characterized in that in parts by weight, the active ingredient
Including：8-9 parts of gadol extract, 6-8 parts of siberian Ginseng P.E, 5-7 parts of Herb Gynostemmae Pentaphylli extract, 5-7 parts of Fructus Monordicae extract,
5-8 parts of Borneolum Syntheticum extract, 10-15 parts of rose extract, 12-15 parts of Notogineng Extract, 6-8 parts of Salvia root P.E, scutellaria extraction
12-18 parts of object, 24-28 parts of angelica extract, 5-6 parts of Rhizoma Smilacis Glabrae extract, 3-5 parts of dandelion extract, Herba Lysimachiae foenumgraeci extract
2-5 parts, 2-5 parts of Angelica Dahurica extract.
3. solubility anti-wrinkle micropin according to claim 2, which is characterized in that in parts by weight, the active ingredient
Including：8.5 parts of gadol extract, 7 parts of siberian Ginseng P.E, 6 parts of Herb Gynostemmae Pentaphylli extract, 6 parts of Fructus Monordicae extract, borneol carries
Take 7 parts of object, 12 parts of rose extract, 13 parts of Notogineng Extract, 7 parts of Salvia root P.E, 15 parts of Scutellaria baicalensis extract, angelica extract
25 parts, 5.5 parts of Rhizoma Smilacis Glabrae extract, 4 parts of dandelion extract, 4 parts of Herba Lysimachiae foenumgraeci extract, 4 parts of Angelica Dahurica extract.
4. solubility anti-wrinkle micropin according to any one of claim 1-3, which is characterized in that in parts by weight, also
Including 8-22 parts of Duyun Maojian Tea extract.
5. solubility anti-wrinkle micropin according to any one of claim 1-3, which is characterized in that further include decoyl salicylic acid
7-30 parts, 0.2-1.8 parts of sodium hydroxide, 50-75 parts of mandelic acid, 1,2- 3-8 parts of hexylene glycol, pungent glycol 1-3 parts.
6. solubility anti-wrinkle micropin according to any one of claim 1-3, which is characterized in that further include surrounding layer, group
Material into surrounding layer is selected from the monomer-polymer or copolymer of vinyl pyrrolidone and its derivative, ethyl cellulose, thoroughly
Bright matter acid, glucan, Polyvinylcaprolactame-polyvinyl acetate-polyethyleneglycol-graft copolymer, hydroxypropyl methylcellulose, first
Base acrylic copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides chondroitin, collagen, shell
It is one or more in glycan, amylopectin, polysaccharide polymer.
7. solubility anti-wrinkle micropin according to claim 6, which is characterized in that the material for forming surrounding layer is hyalomitome
Acid, the mass concentration of the hyaluronic acid is 15%~20%.
8. a kind of preparation method of soluble anti-wrinkle micropin described in claim 1, which is characterized in that include the following steps：
S1：Prepare gadol extract, siberian Ginseng P.E, Herb Gynostemmae Pentaphylli extract, Fructus Monordicae extract, Borneolum Syntheticum extract, rose
Rare extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, angelica extract, Rhizoma Smilacis Glabrae extract, dandelion extraction
Object, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract are spare；
S2：By weight, the gadol extract obtained by weighing respectively in step S1, siberian Ginseng P.E, Herb Gynostemmae Pentaphylli extract,
Fructus Monordicae extract, Borneolum Syntheticum extract, rose extract, Notogineng Extract, Salvia root P.E, Scutellaria baicalensis extract, Radix Angelicae Sinensis extraction
Object, Rhizoma Smilacis Glabrae extract, dandelion extract, Herba Lysimachiae foenumgraeci extract, Angelica Dahurica extract, Duyun Maojian Tea extract, addition are gone
300-400 parts of ionized water, is mixed evenly, filters to take filtrate；
S3：Decoyl salicylic acid is weighed according to parts by weight, and sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol adds it to
It in filtrate described in step S2, is uniformly mixed, less than 40 DEG C rotary evaporations remove moisture, form having for soluble anti-wrinkle micropin
Imitate ingredient；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made；
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken out, it is suitable
Hour hands are rotated by 90 ° placement, are rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, it is horizontal under 1000rpm again
Centrifugation 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble anti-wrinkle micropin in step S3 is added in step S5 in the mold containing surrounding layer,
It dries, demoulds after dry up to soluble anti-wrinkle micropin again.
9. a kind of microneedle configuration of solubility anti-wrinkle, which is characterized in that the microneedle configuration of the solubility anti-wrinkle includes needle point
(1), needle base (2), the needle point (1) are set on the needle on base (2), and needle base (2) outer layer is provided with surrounding layer (3).
10. the microneedle configuration of solubility anti-wrinkle according to claim 9, which is characterized in that the height of the needle point (1) is
50-500 microns.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846808A (en) * | 2019-03-20 | 2019-06-07 | 广州纳丽生物科技有限公司 | Crystallite injection liquid cosmetics, preparation method and skin makeup rifle with spot-removing function |
| CN109846785A (en) * | 2019-03-20 | 2019-06-07 | 广州纳丽生物科技有限公司 | A kind of solvable micropin and preparation method thereof with spot-removing function |
| CN111053715A (en) * | 2019-10-22 | 2020-04-24 | 广东雅姿精化有限公司 | High-molecular soluble microneedle and production method thereof |
| CN111297806A (en) * | 2020-01-17 | 2020-06-19 | 浙江大学 | Salidroside transdermal whitening preparation based on vesicle carrier and preparation method and application thereof |
-
2018
- 2018-02-28 CN CN201810166379.1A patent/CN108236758A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846808A (en) * | 2019-03-20 | 2019-06-07 | 广州纳丽生物科技有限公司 | Crystallite injection liquid cosmetics, preparation method and skin makeup rifle with spot-removing function |
| CN109846785A (en) * | 2019-03-20 | 2019-06-07 | 广州纳丽生物科技有限公司 | A kind of solvable micropin and preparation method thereof with spot-removing function |
| CN111053715A (en) * | 2019-10-22 | 2020-04-24 | 广东雅姿精化有限公司 | High-molecular soluble microneedle and production method thereof |
| CN111297806A (en) * | 2020-01-17 | 2020-06-19 | 浙江大学 | Salidroside transdermal whitening preparation based on vesicle carrier and preparation method and application thereof |
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