CN108310620A - A kind of solubility Whitening, spot micropin and preparation method thereof - Google Patents
A kind of solubility Whitening, spot micropin and preparation method thereof Download PDFInfo
- Publication number
- CN108310620A CN108310620A CN201810166369.8A CN201810166369A CN108310620A CN 108310620 A CN108310620 A CN 108310620A CN 201810166369 A CN201810166369 A CN 201810166369A CN 108310620 A CN108310620 A CN 108310620A
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- spot
- whitening
- micropin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of soluble Whitening, spot micropins, including needle point (1), and the needle point (1) includes active ingredient, and in parts by weight, the active ingredient includes：25 35 parts of angelica extract, 10 18 parts of Semen Persicae extract, 13 18 parts of Salvia root P.E, 25 35 parts of Rhizoma Typhonii extract, 25 35 parts of Margarita powder extract, 10 25 parts of Angelica Dahurica extract, 10 20 parts of rose extract, 20 42 parts of scutellaria root extract, 8 30 parts of peony root extractive, 10 50 parts of Radix Rubiae Yunnanensis extract, 10 30 parts of Rocket ram jet extract, 20 40 parts of mulberries extract, 20 40 parts of Herba Saxifragae extract, 10 15 parts of Fructus Gleditsiae Abnormalis extract, 20 40 parts of Radix Mirabilis extract, 10 20 parts of Fructus Rosae Normalis extract.This micropin Whitening, spot is with obvious effects.
Description
Technical field
The invention belongs to beauty appliance fields, and in particular to a kind of solubility Whitening, spot micropin and preparation method thereof.
Background technology
Existing Whitening, spot product mainly has medicine shaping and beauty, whitening spot-relieving cream, Whitening, spot lotion etc., however existing
There is also many disadvantages for some Whitening, spot products, and traditional Chinese medicine shaping and beauty is although quick, but somewhat expensive, and whitening
The material and preparation of light spot still remain defect, are easy to bring complication to consumer；And existing whitening spot-relieving cream, whitening are light
Spot lotion, since skin barrier acts on, functional component tends not to effectively absorb, and effect is limited.
Invention content
The main object of the present invention is to provide for a kind of soluble Whitening, spot micropin and preparation method thereof, existing to solve
The problem for having Whitening, spot product Whitening, spot effect bad.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of solubility Whitening, spot micropin, including needle point 1, the needle point 1 include active ingredient, in parts by weight,
The active ingredient includes：
25-35 parts of angelica extract, 10-18 parts of Semen Persicae extract, 13-18 parts of Salvia root P.E, Rhizoma Typhonii extract 25-
35 parts, 25-35 parts of Margarita powder extract, 10-25 parts of Angelica Dahurica extract, 10-20 parts of rose extract, scutellaria root extract 20-
42 parts, 8-30 parts of peony root extractive, 10-50 parts of Radix Rubiae Yunnanensis extract, 10-30 parts of Rocket ram jet extract, mulberries extract
20-40 parts, 20-40 parts of Herba Saxifragae extract, 10-15 parts of Fructus Gleditsiae Abnormalis extract, 20-40 parts of Radix Mirabilis extract, Fructus Rosae Normalis extract
10-20 parts.
Preferably, in parts by weight, the active ingredient includes：28-32 parts of angelica extract, Semen Persicae extract 11-
17 parts, 14-18 parts of Salvia root P.E, 28-32 parts of Rhizoma Typhonii extract, 28-32 parts of Margarita powder extract, Angelica Dahurica extract 15-
22 parts, 12-18 parts of rose extract, 25-40 parts of scutellaria root extract, 10-25 parts of peony root extractive, Radix Rubiae Yunnanensis extract
15-40 parts, 15-28 parts of Rocket ram jet extract, 25-35 parts of mulberries extract, 25-40 parts of Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract
11-15 parts, 25-35 parts of Radix Mirabilis extract, 12-18 parts of Fructus Rosae Normalis extract.
Preferably, in parts by weight, the active ingredient includes：30 parts of angelica extract, 15 parts of Semen Persicae extract are red
16 parts of conopsea extraction, 30 parts of Rhizoma Typhonii extract, 30 parts of Margarita powder extract, 20 parts of Angelica Dahurica extract, 15 parts of rose extract,
35 parts of scutellaria root extract, 20 parts of peony root extractive, 35 parts of Radix Rubiae Yunnanensis extract, 20 parts of Rocket ram jet extract, mulberries extraction
30 parts of object, 30 parts of Herba Saxifragae extract, 12 parts of Fructus Gleditsiae Abnormalis extract, 30 parts of Radix Mirabilis extract, 15 parts of Fructus Rosae Normalis extract.
Preferably, in parts by weight, further include 8-22 parts of Duyun Maojian Tea extract.
Preferably, further include 7-30 parts of decoyl salicylic acid, 0.2-1.8 parts of sodium hydroxide, 50-75 parts of mandelic acid, 1,2- oneself
3-8 parts of glycol, pungent glycol 1-3 parts.
Preferably, further include surrounding layer, the material for forming surrounding layer is selected from the list of vinyl pyrrolidone and its derivative
Body polymer or copolymer, ethyl cellulose, hyaluronic acid, glucan, soluplus, hydroxypropyl methylcellulose, methacrylic acid
Copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides chondroitin, collagen, chitosan, branch
It is one or more in starch, polysaccharide polymer.
Preferably, the material for forming surrounding layer is hyaluronic acid, the mass concentration of the hyaluronic acid is 15%~
20%.
A kind of preparation method of soluble Whitening, spot micropin described in claim 1, includes the following steps：
S1：Prepare angelica extract, Semen Persicae extract, Salvia root P.E, Rhizoma Typhonii extract, Margarita powder extract, in vain
Root of Dahurian angelica extract, rose extract, scutellaria root extract, peony root extractive, Radix Rubiae Yunnanensis extract, Rocket ram jet extract, mulberries
Extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract are spare；
S2：By weight, the angelica extract obtained by weighing respectively in step S1, Semen Persicae extract, Salvia root P.E, in vain
Monkshood extract, Margarita powder extract, Angelica Dahurica extract, rose extract, scutellaria root extract, peony root extractive are small red
Conopsea extraction, Rocket ram jet extract, mulberries extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Rosa roxburghii Tratt carry
Take object, Duyun Maojian Tea extract that 300-400 parts of deionized water is added, is mixed evenly, filters to take filtrate；
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble Whitening, spot
The active ingredient of micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made；
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal minute；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble Whitening, spot micropin in step S3 is added in step S5 containing surrounding layer
It in mold, dries, demoulds after dry up to soluble Whitening, spot micropin again.
A kind of microneedle configuration of solubility Whitening, spot, the microneedle configuration of the solubility Whitening, spot includes needle point 1, needle
Base 2, ice sheet 5 and articulamentum 4, the needle point 1 are connect with the needle base 2, and 2 outer layer of needle base is provided with surrounding layer 3；It is described
Needle base 2 is connect with the articulamentum 4, and the ice sheet 5 is connect with described with the needle point 1.
Preferably, the height of the needle point 1 is 50-500 microns.
Compared with prior art, soluble Whitening, spot micropin of the present invention and preparation method thereof at least has following
Advantageous effect：
1) active ingredient in the present invention, selects by the height to various Whitening, spot drugs and carries out optimal combination,
To reduce the dosage and toxic side effect of each drug, expand its safe range and use scope.
2) angelica extract in active ingredient of the present invention, Semen Persicae extract, Salvia root P.E, Rhizoma Typhonii extract are precious
Pearl powder extracts, Angelica Dahurica extract, rose extract, scutellaria root extract, peony root extractive, Radix Rubiae Yunnanensis extract, fiery spine
Berry extract, mulberries extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Fructus Rosae Normalis extract and all even high-quality green tea
The Chinese medical extracts such as tea extraction can improve the metabolism of skin while Whitening, spot, improve micro- around spot
Environment, fundamentally Whitening, spot.
3) soluble Whitening, spot micropin provided by the invention has biodegradable, can be completely dissolved in skin or
Degradation.Prepare surrounding layer using hyaluronic acid, on the one hand can protect active ingredient, avoid active ingredient contact external environment and
Aoxidized or gone bad etc.；On the other hand, hyaluronic acid can dissolve rapidly, discharge the active ingredient of the inside, and the solubility whitening
Light spot micropin has certain slow release effect.
4) soluble Whitening, spot micropin provided by the invention can rapidly dissolve inside skin, reach speckle or skin
It at skin dull, compared with oral conditioning, can substantially shorten treatment time, avoid drug from being absorbed through gastrointestinal disturbances and lower effectively
The content of ingredient, or the dosage of big active ingredient must not be not added with because ensureing the content of active ingredient, improve cost；With directly painting
Deposited skin condition is compared, and solubility Whitening, spot micropin provided by the invention can be reached directly at spot, avoid skin to having
The blocking of ingredient is imitated, and because skin absorption is slower, active ingredient is failed by Oxidative demage.
5) soluble Whitening, spot micropin provided by the invention can be completely dissolved so that active ingredient free of losses improves
The utilization rate of active ingredient is directly applied to affected part, directly improves the metabolism having in affected part, efficient, cost
It is low, active ingredient can be avoided to cause unnecessary stimulation to other positions.
6) Whitening, spot micropin provided by the invention is readily produced, transports and stores, and reduces cost.
7) Whitening, spot micropin provided by the invention coordinates corresponding instrument, or does not have to instrument, and being in voluntarily to grasp
Make, without going to beauty parlor.Not only safety, but it is time saving, economical.
Description of the drawings
Fig. 1 is the structural schematic diagram of the soluble Whitening, spot micropin of the present invention.
Specific implementation mode
The invention will be further described with reference to the accompanying drawings and examples, and following embodiment is descriptive, is not
Limited, protection scope of the present invention cannot be limited with this.
Keep the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction in the embodiment of the present invention
Attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is this
Invention a part of the embodiment, instead of all the embodiments.Embodiments of the present invention, which are generally described and illustrated herein in the accompanying drawings
Component can arrange and design with a variety of different configurations.Therefore, the implementation to the present invention provided in the accompanying drawings below
The detailed description of example is not intended to limit the range of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end
Same or similar label indicates same or similar element or element with the same or similar functions.Below with reference to attached
The embodiment of figure description is exemplary, it is intended to for explaining the present invention, and is not considered as limiting the invention.
Extract in the present invention：Refer to a kind of by impregnating or being mixed in solvent by the substance of extract to be obtained
The solution for extracting and obtaining.Extraction process can carry out with the help of selection suitable solvent, such as：Water, ethyl alcohol, ethanol/water
Mixture, methanol, propyl alcohol, butanol, chloroform, acetone or other organic solvents, and by isolation, diafiltration, decoction, counter-current extraction,
Ultrasonic wave, microwave, supercritical fluid extraction method obtain extract, extract is further concentrated by evaporation, and obtains medicinal extract and dry
Dry extract.
The present invention provides a kind of soluble Whitening, spot micropin, including needle point 1, and the needle point 1 includes active ingredient, according to
Parts by weight meter, active ingredient include：25-35 parts of angelica extract, 10-18 parts of Semen Persicae extract, 13-18 parts of Salvia root P.E,
25-35 parts of Rhizoma Typhonii extract, 25-35 parts of Margarita powder extract, 10-25 parts of Angelica Dahurica extract, 10-20 parts of rose extract,
20-42 parts of scutellaria root extract, 8-30 parts of peony root extractive, 10-50 parts of Radix Rubiae Yunnanensis extract, Rocket ram jet extract 10-30
Part, 20-40 parts of mulberries extract, 20-40 parts of Herba Saxifragae extract, 10-15 parts of Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract 20-40
Part, 10-20 parts of Fructus Rosae Normalis extract, 8-22 parts of Duyun Maojian Tea extract, 7-30 parts of decoyl salicylic acid, sodium hydroxide 0.2-1.8
Part, 50-75 parts of mandelic acid, 1,2- 3-8 parts of hexylene glycol, pungent glycol 1-3 parts.
Solubility Whitening, spot micropin provided by the invention further includes surrounding layer.Surrounding layer mainly uses hyaluronic acid.Thoroughly
Bright matter acid shows a variety of important physiological functions with its unique molecular structure and physicochemical property in body, and such as lubrication is closed
Section adjusts the permeability of vascular wall, regulatory protein matter, Water-Electrolyte diffusion and operating, promotion, acceleration of wound healing etc..Certainly
Other high molecular materials may be used in surrounding layer, such as vinyl pyrrolidone and its monomer-polymer or copolymer of derivative,
Ethyl cellulose, hyaluronic acid, glucan, soluplus (Polyvinylcaprolactames-polyvinyl acetate-polyethylene glycol grafting
Copolymer), hydroxypropyl methylcellulose, methacrylic acid copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid,
One or more of peptides chondroitin, collagen, chitosan, amylopectin, polysaccharide polymer etc..
The preparation method of above-mentioned solubility Whitening, spot micropin, mainly includes the following steps that：
S1：Prepare angelica extract, Semen Persicae extract, Salvia root P.E, Rhizoma Typhonii extract, Margarita powder extract, in vain
Root of Dahurian angelica extract, rose extract, scutellaria root extract, peony root extractive, Radix Rubiae Yunnanensis extract, Rocket ram jet extract, mulberries
Extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract are spare.
S2：By weight, the angelica extract obtained by weighing respectively in step S1, Semen Persicae extract, Salvia root P.E, in vain
Monkshood extract, Margarita powder extract, Angelica Dahurica extract, rose extract, scutellaria root extract, peony root extractive are small red
Conopsea extraction, Rocket ram jet extract, mulberries extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Rosa roxburghii Tratt carry
Take object, Duyun Maojian Tea extract that 300-400 parts of deionized water is added, is mixed evenly, filters to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble Whitening, spot
The active ingredient of micropin.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble Whitening, spot micropin in step S3 is added in step S5 containing surrounding layer
It in mold, dries, demoulds after dry up to soluble Whitening, spot micropin again.
The microneedle configuration of soluble Whitening, spot includes needle point 1, needle base 2, and the needle point 1 is connect with the needle base 2, institute
It states 2 outer layer of needle base and is provided with surrounding layer 3；The needle point 1 is cone or triangle.The height of the needle point 1 is that 50-500 is micro-
Rice.
Embodiment 1
The present embodiment provides a kind of soluble Whitening, spot micropins, including needle point 1, the needle point 1 include active ingredient, are pressed
According to parts by weight meter, active ingredient includes：28 parts of angelica extract, 10 parts of Semen Persicae extract, 13 parts of Salvia root P.E, rhizoma typhonii carries
Take 25 parts of object, 25 parts of Margarita powder extract, 10 parts of Angelica Dahurica extract, 10 parts of rose extract, 20 parts of scutellaria root extract is male
10 parts of red root extract, 20 parts of Radix Rubiae Yunnanensis extract, 15 parts of Rocket ram jet extract, 40 parts of mulberries extract, Herba Saxifragae extract
25 parts, 10 parts of Fructus Gleditsiae Abnormalis extract, 20 parts of Radix Mirabilis extract, 12 parts of Fructus Rosae Normalis extract, 10 parts of Duyun Maojian Tea extract is pungent
7 parts of acyl salicylic acid, 0.2 part of sodium hydroxide, 50 parts of mandelic acid, 1,2- 3 parts of hexylene glycol, 1 part of pungent glycol.
The preparation method of above-mentioned solubility Whitening, spot micropin, includes the following steps：
S1：Prepare angelica extract, Semen Persicae extract, Salvia root P.E, Rhizoma Typhonii extract, Margarita powder extract, in vain
Root of Dahurian angelica extract, rose extract, scutellaria root extract, peony root extractive, Radix Rubiae Yunnanensis extract, Rocket ram jet extract, mulberries
Extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract are spare.
S2：By weight, the angelica extract obtained by weighing respectively in step S1, Semen Persicae extract, Salvia root P.E, in vain
Monkshood extract, Margarita powder extract, Angelica Dahurica extract, rose extract, scutellaria root extract, peony root extractive are small red
Conopsea extraction, Rocket ram jet extract, mulberries extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Rosa roxburghii Tratt carry
Take object, Duyun Maojian Tea extract that 300 parts of deionized water is added, is mixed evenly, filters to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble Whitening, spot
The active ingredient of micropin.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble Whitening, spot micropin in step S3 is added in step S5 containing surrounding layer
It in mold, dries, demoulds after dry up to soluble Whitening, spot micropin again.The microneedle configuration of soluble Whitening, spot includes
Needle point 1, needle base 2, the needle point 1 are connect with the needle base 2, and 2 outer layer of needle base is provided with surrounding layer 3；The needle point 1 is circle
Taper or triangle are highly 50 microns.Micropin is connect by articulamentum 4 with external device.
Embodiment 2
The present embodiment provides a kind of soluble Whitening, spot micropins, including needle point 1, the needle point 1 include active ingredient, are pressed
According to parts by weight meter, active ingredient includes：32 parts of angelica extract, 18 parts of Semen Persicae extract, 18 parts of Salvia root P.E, rhizoma typhonii carries
Take 35 parts of object, 35 parts of Margarita powder extract, 15 parts of Angelica Dahurica extract, 20 parts of rose extract, 25 parts of scutellaria root extract is male
15 parts of red root extract, 25 parts of Radix Rubiae Yunnanensis extract, 25 parts of Rocket ram jet extract, 20 parts of mulberries extract, Herba Saxifragae extract
40 parts, 15 parts of Fructus Gleditsiae Abnormalis extract, 40 parts of Radix Mirabilis extract, 18 parts of Fructus Rosae Normalis extract, 12 parts of Duyun Maojian Tea extract is pungent
20 parts of acyl salicylic acid, 0.5 part of sodium hydroxide, 60 parts of mandelic acid, 1,2- 5 parts of hexylene glycol, 1.5 parts of pungent glycol.
The preparation method of above-mentioned solubility Whitening, spot micropin, includes the following steps：
S1：Prepare angelica extract, Semen Persicae extract, Salvia root P.E, Rhizoma Typhonii extract, Margarita powder extract, in vain
Root of Dahurian angelica extract, rose extract, scutellaria root extract, peony root extractive, Radix Rubiae Yunnanensis extract, Rocket ram jet extract, mulberries
Extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract are spare.
S2：By weight, the angelica extract obtained by weighing respectively in step S1, Semen Persicae extract, Salvia root P.E, in vain
Monkshood extract, Margarita powder extract, Angelica Dahurica extract, rose extract, scutellaria root extract, peony root extractive are small red
Conopsea extraction, Rocket ram jet extract, mulberries extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Rosa roxburghii Tratt carry
Take object, Duyun Maojian Tea extract that 350 parts of deionized water is added, is mixed evenly, filters to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble Whitening, spot
The active ingredient of micropin.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 18% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble Whitening, spot micropin in step S3 is added in step S5 containing surrounding layer
It in mold, dries, demoulds after dry up to soluble Whitening, spot micropin again.The microneedle configuration of soluble Whitening, spot includes
Needle point 1, needle base 2, the needle point 1 are connect with the needle base 2, and 2 outer layer of needle base is provided with surrounding layer 3；The needle point 1 is circle
Taper or triangle are highly 100 microns.Micropin is connect by articulamentum 4 with external device.
Embodiment 3
The present embodiment provides a kind of soluble Whitening, spot micropins, including needle point 1, the needle point 1 include active ingredient, are pressed
According to parts by weight meter, active ingredient includes：35 parts of angelica extract, 12 parts of Semen Persicae extract, 15 parts of Salvia root P.E, rhizoma typhonii carries
Take 34 parts of object, 32 parts of Margarita powder extract, 25 parts of Angelica Dahurica extract, 18 parts of rose extract, 40 parts of scutellaria root extract is male
25 parts of red root extract, 140 parts of Radix Rubiae Yunnanensis extract, 30 parts of Rocket ram jet extract, 25 parts of mulberries extract, Herba Saxifragae extract
35 parts, 14 parts of Fructus Gleditsiae Abnormalis extract, 25 parts of Radix Mirabilis extract, 16 parts of Fructus Rosae Normalis extract, 20 parts of Duyun Maojian Tea extract is pungent
2 parts of 15 parts of acyl salicylic acid, 1 part of sodium hydroxide, 70 parts of mandelic acid, 1,2- 4 parts of hexylene glycol and pungent glycol.
The preparation method of above-mentioned solubility Whitening, spot micropin, includes the following steps：
S1：Prepare angelica extract, Semen Persicae extract, Salvia root P.E, Rhizoma Typhonii extract, Margarita powder extract, in vain
Root of Dahurian angelica extract, rose extract, scutellaria root extract, peony root extractive, Radix Rubiae Yunnanensis extract, Rocket ram jet extract, mulberries
Extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract are spare.
S2：By weight, the angelica extract obtained by weighing respectively in step S1, Semen Persicae extract, Salvia root P.E, in vain
Monkshood extract, Margarita powder extract, Angelica Dahurica extract, rose extract, scutellaria root extract, peony root extractive are small red
Conopsea extraction, Rocket ram jet extract, mulberries extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Rosa roxburghii Tratt carry
Take object, Duyun Maojian Tea extract that 380 parts of deionized water is added, is mixed evenly, filters to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble Whitening, spot
The active ingredient of micropin.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 16% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble Whitening, spot micropin in step S3 is added in step S5 containing surrounding layer
It in mold, dries, demoulds after dry up to soluble Whitening, spot micropin again.The microneedle configuration of soluble Whitening, spot includes
Needle point 1, needle base 2, the needle point 1 are connect with the needle base 2, and 2 outer layer of needle base is provided with surrounding layer 3；The needle point 1 is circle
Taper or triangle are highly 200 microns.Micropin is connect by articulamentum 4 with external device.
Embodiment 4
The present embodiment provides a kind of soluble Whitening, spot micropins, including needle point 1, the needle point 1 include active ingredient, are pressed
According to parts by weight meter, the active ingredient includes：30 parts of angelica extract, 15 parts of Semen Persicae extract, 16 parts of Salvia root P.E, in vain
30 parts of monkshood extract, 30 parts of Margarita powder extract, 20 parts of Angelica Dahurica extract, 15 parts of rose extract, scutellaria root extract 35
Part, 20 parts of peony root extractive, 35 parts of Radix Rubiae Yunnanensis extract, 20 parts of Rocket ram jet extract, 30 parts of mulberries extract, kiss-me carries
Take 30 parts of object, 12 parts of Fructus Gleditsiae Abnormalis extract, 30 parts of Radix Mirabilis extract, 15 parts of Fructus Rosae Normalis extract, Duyun Maojian Tea extract 15
2.5 parts of part, 25 parts of decoyl salicylic acid, 0.8 part of sodium hydroxide, 55 parts of mandelic acid, 1,2- 6 parts of hexylene glycol and pungent glycol.
The preparation method of above-mentioned solubility Whitening, spot micropin, includes the following steps：
S1：Prepare angelica extract, Semen Persicae extract, Salvia root P.E, Rhizoma Typhonii extract, Margarita powder extract, in vain
Root of Dahurian angelica extract, rose extract, scutellaria root extract, peony root extractive, Radix Rubiae Yunnanensis extract, Rocket ram jet extract, mulberries
Extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract are spare.
S2：By weight, the angelica extract obtained by weighing respectively in step S1, Semen Persicae extract, Salvia root P.E, in vain
Monkshood extract, Margarita powder extract, Angelica Dahurica extract, rose extract, scutellaria root extract, peony root extractive are small red
Conopsea extraction, Rocket ram jet extract, mulberries extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Rosa roxburghii Tratt carry
Take object, Duyun Maojian Tea extract that 320 parts of deionized water is added, is mixed evenly, filters to take filtrate.
S3：Weigh decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, by itself plus
Enter into the filtrate described in step S2, be uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble Whitening, spot
The active ingredient of micropin.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 20% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken
Go out, rotate clockwise 90 ° of placements, is rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm
Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble Whitening, spot micropin in step S3 is added in step S5 containing surrounding layer
It in mold, dries, demoulds after dry up to soluble Whitening, spot micropin again.The microneedle configuration of soluble Whitening, spot includes
Needle point 1, needle base 2, the needle point 1 are connect with the needle base 2, and 2 outer layer of needle base is provided with surrounding layer 3；The needle point 1 is circle
Taper or triangle are highly 400 microns.Micropin is connect by articulamentum 4 with external device.
The formula of micropin needle point in above-described embodiment may also be fabricated which drink (such as effervescent tablet etc.), while using micropin
Drink is taken, it is better.
The application example of product of the present invention is illustratively introduced with the product prepared in embodiment 4 below.The present invention other
Product in embodiment has the effect of similar.
For the present invention from numerous volunteers, it is 25-55 Sui to have selected age bracket, suffers from brindled 300 women aspiration
Person.300 volunteers are randomly divided into three groups, A groups, B groups and C groups, and the number of each age group is essentially identical.Will in A groups
Hope person uses the product prepared in the embodiment of the present invention 4, daily using primary；Volunteer in B groups uses Whitening, spot drug
(commercially available), takes daily, twice a day；Volunteer in C groups is by moving Whitening, spot.After tracking 1 year, result is such as
Under：
Following table is the product Piglet s colibacillosis result in the embodiment of the present invention 4：
Wherein, criterion of therapeutical effect is：Recovery from illness：Speckle or the intensely dark place of skin are dispelled completely；It is effective：Whitening, spot rate reaches
50% or more；Effectively：Whitening, spot rate is up to 10% or more；In vain：It is unchanged before and after treatment.
The product that the embodiment of the present invention 4 provides, which is can be seen that, from the experimental result in table 1 is substantially better than commercial product.With
After track 1 year, in A groups, the product that is provided using the embodiment of the present invention 4 can effective Whitening, spot, cure rate reaches
93%, the volunteer not cured is obviously improved, and it is longer to cure the time needed.In B groups, use is commercially available
Whitening, spot medicine, Whitening, spot effect is not apparent.In C groups, by movement Whitening, spot almost without effect.
Solubility Whitening, spot micropin provided by the invention, Whitening, spot is with obvious effects, efficient, and can improve spot
The metabolism in portion so that skin restores normal physiological function, fundamentally Whitening, spot.
In conjunction with Fig. 1, invention is further explained.
As shown in Figure 1, for the structural schematic diagram of the soluble Whitening, spot micropin of the present invention, including needle point 1, needle base 2, ice sheet
5 and articulamentum 4, the needle point 1 connect with the needle base 2,2 outer layer of needle base is provided with surrounding layer 3；The needle base 2 and institute
The connection of articulamentum 4 is stated, the ice sheet 5 is connect with described with the needle point 1.The needle point 1 is cone or triangle.It is described
The height of needle point 1 is 300 microns -500 microns.Needle point 1 is equally spaced, and the distance between needle point 1 is 0.4 millimeter -0.8 millimeter.
The base diameter of needle point 1 is 100 microns -200 microns.2 height of needle base is 100 microns -200 microns.Ice sheet 5 is arranged in needle
Point 1 enters one end of skin, and when needle point 1 is pierced into skin, ice sheet 5 can play the role of skin ice compress, and then needle point 1 is being pierced into
There is no feeling of pain when skin.
The material of surrounding layer 3 mainly uses hyaluronic acid in the present embodiment.Hyaluronic acid with its unique molecular structure and
Physicochemical property shows that a variety of important physiological functions, such as lubricating joint adjust the permeability of vascular wall in body, adjusts egg
White matter, Water-Electrolyte diffusion and operating, promotion, acceleration of wound healing etc..Micropin, which is pierced into skin, forms pin hole, and surrounding layer can be with
So that pin hole is faster healed and drug absorption can be promoted.Other macromolecule materials may be used in the material of certain surrounding layer 3, such as
The monomer-polymer or copolymer of vinyl pyrrolidone and its derivative, ethyl cellulose, hyaluronic acid, glucan,
Soluplus (Polyvinylcaprolactame-polyvinyl acetate-polyethyleneglycol-graft copolymer), hydroxypropyl methylcellulose, methyl-prop
Olefin(e) acid copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides chondroitin, collagen, chitosan,
One or more of amylopectin, polysaccharide polymer etc..
Needle point 1 is set on needle base 2, and after micropin is pierced into skin, needle point 1 is pierced into deep skin, and needle base 2 stays in shallow-layer
Skin.Since needle point 1 is that cone or triangle and needle point 1 are set on needle base 2, when extracting micropin, needle point 1 and
Needle base 2 detaches, and needle point 1, which stays in skin, continues to play drug effect, and needle base 2 is extracted.Surrounding layer 3 promotes pin hole healing.
More than, it is merely preferred embodiments of the present invention, but the protection domain invented is not limited thereto, it is any ripe
Know those skilled in the art in the technical scope disclosed by the present invention, the change or replacement that can be readily occurred in should all be contained
Lid is within protection scope of the present invention.Therefore, the scope of protection of the invention shall be subject to the scope of protection specified in the patent claim.
Claims (10)
1. a kind of solubility Whitening, spot micropin, including needle point (1), which is characterized in that the needle point (1) includes active ingredient,
In parts by weight, the active ingredient includes：
25-35 parts of angelica extract, 10-18 parts of Semen Persicae extract, 13-18 parts of Salvia root P.E, Rhizoma Typhonii extract 25-35
Part, 25-35 parts of Margarita powder extract, 10-25 parts of Angelica Dahurica extract, 10-20 parts of rose extract, scutellaria root extract 20-42
Part, 8-30 parts of peony root extractive, 10-50 parts of Radix Rubiae Yunnanensis extract, 10-30 parts of Rocket ram jet extract, mulberries extract 20-40
Part, 20-40 parts of Herba Saxifragae extract, 10-15 parts of Fructus Gleditsiae Abnormalis extract, 20-40 parts of Radix Mirabilis extract, Fructus Rosae Normalis extract 10-20
Part.
2. solubility Whitening, spot micropin according to claim 1, which is characterized in that in parts by weight, described effective
Ingredient includes：28-32 parts of angelica extract, 11-17 parts of Semen Persicae extract, 14-18 parts of Salvia root P.E, Rhizoma Typhonii extract
28-32 parts, 28-32 parts of Margarita powder extract, 15-22 parts of Angelica Dahurica extract, 12-18 parts of rose extract, scutellaria root extract
25-40 parts, 10-25 parts of peony root extractive, 15-40 parts of Radix Rubiae Yunnanensis extract, 15-28 parts of Rocket ram jet extract, mulberries extraction
25-35 parts of object, 25-40 parts of Herba Saxifragae extract, 11-15 parts of Fructus Gleditsiae Abnormalis extract, 25-35 parts of Radix Mirabilis extract, Rosa roxburghii Tratt extraction
12-18 parts of object.
3. solubility Whitening, spot micropin according to claim 2, which is characterized in that in parts by weight, described effective
Ingredient includes：30 parts of angelica extract, 15 parts of Semen Persicae extract, 16 parts of Salvia root P.E, 30 parts of Rhizoma Typhonii extract, pearl powder
30 parts of extract, 20 parts of Angelica Dahurica extract, 15 parts of rose extract, 35 parts of scutellaria root extract, 20 parts of peony root extractive are small
35 parts of red ginseng extract, 20 parts of Rocket ram jet extract, 30 parts of mulberries extract, 30 parts of Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract 12
Part, 30 parts of Radix Mirabilis extract, 15 parts of Fructus Rosae Normalis extract.
4. solubility Whitening, spot micropin according to any one of claim 1-3, which is characterized in that according to parts by weight
Meter, further includes 8-22 parts of Duyun Maojian Tea extract.
5. solubility Whitening, spot micropin according to any one of claim 1-3, which is characterized in that further include decoyl water
7-30 parts of poplar acid, 0.2-1.8 parts of sodium hydroxide, 50-75 parts of mandelic acid, 1,2- 3-8 parts of hexylene glycol, pungent glycol 1-3 parts.
6. solubility Whitening, spot micropin according to any one of claim 1-3, which is characterized in that further include outsourcing
Layer, the material for forming surrounding layer are selected from monomer-polymer or copolymer, the ethyl cellulose of vinyl pyrrolidone and its derivative
Element, hyaluronic acid, glucan, Polyvinylcaprolactame-polyvinyl acetate-polyethyleneglycol-graft copolymer, hypromellose
Element, methacrylic acid copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides chondroitin, collagen egg
In vain, one or more in chitosan, amylopectin, polysaccharide polymer.
7. solubility Whitening, spot micropin according to claim 6, which is characterized in that the material for forming surrounding layer is transparent
The mass concentration of matter acid, the hyaluronic acid is 15%~20%.
8. a kind of preparation method of soluble Whitening, spot micropin described in claim 1, which is characterized in that including walking as follows
Suddenly：
S1：Prepare angelica extract, Semen Persicae extract, Salvia root P.E, Rhizoma Typhonii extract, Margarita powder extract, the root of Dahurain angelica carries
Take object, rose extract, scutellaria root extract, peony root extractive, Radix Rubiae Yunnanensis extract, Rocket ram jet extract, mulberries extraction
Object, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Fructus Rosae Normalis extract, Duyun Maojian Tea extract are spare；
S2：By weight, the angelica extract of gained in step S1, Semen Persicae extract, Salvia root P.E, rhizoma typhonii are weighed respectively
Extract, Margarita powder extract, Angelica Dahurica extract, rose extract, scutellaria root extract, peony root extractive, rubia yunnanensis carry
Take object, Rocket ram jet extract, mulberries extract, Herba Saxifragae extract, Fructus Gleditsiae Abnormalis extract, Radix Mirabilis extract, Fructus Rosae Normalis extract,
Duyun Maojian Tea extract is added 300-400 parts of deionized water, is mixed evenly, filters to take filtrate；
S3：Decoyl salicylic acid is weighed according to parts by weight, and sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol adds it to
It in filtrate described in step S2, is uniformly mixed, 40 DEG C or less rotary evaporations remove moisture, form soluble Whitening, spot micropin
Active ingredient；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made；
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken out, it is suitable
Hour hands are rotated by 90 ° placement, are rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, it is horizontal under 1000rpm again
Centrifugation 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble Whitening, spot micropin in step S3 is added to the mold containing surrounding layer in step S5
In, it dries, demoulds after dry up to soluble Whitening, spot micropin again.
9. a kind of microneedle configuration of solubility Whitening, spot, which is characterized in that the microneedle configuration packet of the solubility Whitening, spot
Needle point (1), needle base (2), ice sheet (5) and articulamentum (4) are included, the needle point (1) connect with the needle base (2), the needle base (2)
Outer layer is provided with surrounding layer (3)；The needle base (2) connect with the articulamentum (4), the ice sheet (5) and the described and needle
Sharp (1) connection.
10. the microneedle configuration of solubility Whitening, spot according to claim 9, which is characterized in that the height of the needle point (1)
Degree is 50-500 microns.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810166369.8A CN108310620A (en) | 2018-02-28 | 2018-02-28 | A kind of solubility Whitening, spot micropin and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810166369.8A CN108310620A (en) | 2018-02-28 | 2018-02-28 | A kind of solubility Whitening, spot micropin and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108310620A true CN108310620A (en) | 2018-07-24 |
Family
ID=62901668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810166369.8A Withdrawn CN108310620A (en) | 2018-02-28 | 2018-02-28 | A kind of solubility Whitening, spot micropin and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108310620A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109620776A (en) * | 2019-02-02 | 2019-04-16 | 广州市禾基生物科技有限公司 | Composition, gel and its preparation method and application |
| CN109846785A (en) * | 2019-03-20 | 2019-06-07 | 广州纳丽生物科技有限公司 | A kind of solvable micropin and preparation method thereof with spot-removing function |
| CN109846808A (en) * | 2019-03-20 | 2019-06-07 | 广州纳丽生物科技有限公司 | Crystallite injection liquid cosmetics, preparation method and skin makeup rifle with spot-removing function |
| CN110870943A (en) * | 2018-08-31 | 2020-03-10 | 中科微针（北京）科技有限公司 | Implantable two-section type microneedle patch and preparation method thereof |
-
2018
- 2018-02-28 CN CN201810166369.8A patent/CN108310620A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110870943A (en) * | 2018-08-31 | 2020-03-10 | 中科微针（北京）科技有限公司 | Implantable two-section type microneedle patch and preparation method thereof |
| CN109620776A (en) * | 2019-02-02 | 2019-04-16 | 广州市禾基生物科技有限公司 | Composition, gel and its preparation method and application |
| CN109620776B (en) * | 2019-02-02 | 2022-02-01 | 广东省禾基生物科技有限公司 | Composition, gel and preparation method and application thereof |
| CN109846785A (en) * | 2019-03-20 | 2019-06-07 | 广州纳丽生物科技有限公司 | A kind of solvable micropin and preparation method thereof with spot-removing function |
| CN109846808A (en) * | 2019-03-20 | 2019-06-07 | 广州纳丽生物科技有限公司 | Crystallite injection liquid cosmetics, preparation method and skin makeup rifle with spot-removing function |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20160136224A1 (en) | Method for preparing a camellia nitidissima chi lipid-lowering and hypoglycemic agent | |
| CN108310620A (en) | A kind of solubility Whitening, spot micropin and preparation method thereof | |
| CN107007477B (en) | Preparation process of modified membrane cloth by multilayer modification method and product thereof | |
| CN102284012B (en) | Gel plaster containing curcumin and bletilla hyacinthina gum and preparation method thereof | |
| CN104784235A (en) | Method for preparing fresh ginsengfreeze-dried oral instant preparation | |
| CN101297867B (en) | Cigarette for quitting drug and preparation thereof | |
| CN108210434A (en) | A kind of soluble reparation scar micropin and preparation method thereof | |
| CN108451844A (en) | A kind of solubility chest enlarge micropin and preparation method thereof | |
| CN103251716B (en) | Swelling-diminishing pain-erasing ointment and preparation method thereof | |
| CN107569421A (en) | A kind of soluble nti-freckle micropin | |
| CA2916423C (en) | Formulation of a micro drop pill and the preparation method thereof | |
| CN108186522A (en) | A kind of solubility is dispelled striae of pregnancy micropin and preparation method thereof | |
| CN101278965A (en) | Soft capsule of humifuse spurge and preparing method thereof | |
| CN101428050B (en) | Active composition for treating thrombus, cardio-cerebrovascular system diseases | |
| CN100544738C (en) | A kind of antineoplastic Chinese medicine preparation | |
| CN103566282A (en) | Traditional Chinese medicine composition with anti-tumor effect and preparation method thereof | |
| CN103099803B (en) | Method for solubilization and synchronous dissolution of bilobalide | |
| CN102283947B (en) | The application of a kind of pharmaceutical composition in preparation iatrotechnics posterior synechiae medicine | |
| CN102475736B (en) | Application of mongolian milkvetch root extract | |
| CN101693073B (en) | Compound caesalpinia pulcherrima spraying agent and preparation method thereof | |
| CN107982484A (en) | Treat Chinese medicinal compound extract of diabetic retinopathy and its preparation method and application | |
| CN107496510B (en) | Cyclocarya paliurus capsule and preparation method thereof | |
| CN101856357A (en) | Application of rotundic acid in preparing medicines for preventing and treating cardiovascular and cerebrovascular diseases | |
| CN1872230B (en) | A medication for treating coronary heart disease and preparation method | |
| CN103550340A (en) | Medicine for treating burns and scalds and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180724 |