CN109620776A

CN109620776A - Composition, gel and its preparation method and application

Info

Publication number: CN109620776A
Application number: CN201910106321.2A
Authority: CN
Inventors: 张文环; 张兵; 张炽坚; 艾勇; 何廷刚; 胡丽云
Original assignee: Guangzhou Heji Biotechnology Co Ltd
Current assignee: Guangzhou Heji Biotechnology Co Ltd
Priority date: 2019-02-02
Filing date: 2019-02-02
Publication date: 2019-04-16
Anticipated expiration: 2039-02-02
Also published as: CN109620776B

Abstract

The present invention relates to traditional Chinese medicine or daily use chemicals technical field, a kind of composition, gel and its preparation method and application are disclosed.The composition contains the first extract, the second extract and water；Wherein, on the basis of the total amount of composition, the content of first extract is 60-90 weight %, and the content of second extract is 0.05-0.3 weight %, and the content of water is 5-40 weight %；First extract is magnolia extract and/or jasmine extract；Second extract is peony root extractive.The gel of composition provided by the invention preparation, Material is pure natural, and appearance transparent is in light green, crystal grain containing pearly-lustre, and has effects that moisturizing, anti-scytitis, anti-dandruff and itching-relieving, antipollution, oxidation resistant.

Description

Composition, gel and its preparation method and application

Technical field

The present invention relates to traditional Chinese medicine or daily use chemicals technical fields, and in particular to a kind of composition, gel and preparation method thereof and Using.

Background technique

With the development of economy, people are no longer strange to cosmetics, in recent years, as caused by the fast development of industry Environmental pollution increasingly aggravates, and various pollutants and particulate matter can weaken the immune system of skin itself and accelerate the aging of skin, Pollution can be generated free radicals in each layer of skin and oxidative stress, causes DNA damage, lipid and protein oxidation, causes lipid It is lacked with stability in protein, is easy that skin is allowed to suffocate；Pollution also easily causes skin barrier to become fragile and sensitive, so as to cause The various defects of skin: inflammation, red capillary, skin relaxation generate wrinkle etc..Therefore the skin care of people protects skin consciousness increasingly By force, skin care item are more and more important in daily life.Requirement of the people to cosmetics in addition to the moisturizing on basis, other than anti-inflammatory efficacy, More and more serious environmental pollution, light aging, ultraviolet damage can be fought, and there is stronger antioxidant activity, removes body Interior free radical is that people are badly in need of, and most important can to treat or mitigate some skin symptoms be even more that people are thought, as most common The symptoms such as dandruff, scalp pruritus.

Plant is rich in many kinds of substance such as protein, amino acid, polysaccharide, polyphenol, flavones, alkaloid, the certain tools of these substances There is very high bioactivity, such as tea polyphenols inoxidizability with higher, blocks peroxidatic reaction of lipid, 1mg tea polyphenols resist Oxidisability is equivalent to 9 μ g superoxide dismutases, is much higher than other allied substances；Berberine from Cortex Phellodendri Chinensis has very strong antibacterial function Effect, to staphylococcus aureus, Escherichia coli, pseudomonas aeruginosa, acne acidfast bacilli and chlosma and white Candida albicans, aspergillus niger minimum inhibitory concentration respectively down to 0.02%, 0.03%, 0.05%, 0.018%, 0.008%, 0.3%, 0.35%.Therefore filtered out from multifarious kind of plant it is some have both effectiveness plant, be applied in cosmetics, be mesh The important link of preceding exploitation cosmetics.

Simultaneously in addition to the promotion that cosmetic industry requires, fashion, fashion, the elements such as attract eyeball are also people to makeup The requirement of product Material form, no longer meets the transparent system of common white emulsion system and dullness, colorful, dazzle cruel, pearly-lustre Crystal grain increasingly becomes the fashion of people's pursuit, and especially pure natural color, pure natural form gain great popularity.

Summary of the invention

It is of the existing technology the purpose of the invention is to overcome the problems, such as, a kind of composition, gel and its preparation are provided Methods and applications, the gel of composition preparation provided by the invention, Material is pure natural, and appearance transparent is in light green, brilliant containing pearly-lustre Grain, and have effects that moisturizing, anti-scytitis, anti-dandruff and itching-relieving, antipollution, oxidation resistant.

To achieve the goals above, first aspect present invention provides a kind of composition, and the composition contains the first extraction Object, the second extract and water；Wherein, on the basis of the total amount of composition, the content of first extract is 60-90 weight % is measured, the content of second extract is 0.05-0.3 weight %, and the content of water is 5-40 weight %；First extract For magnolia extract and/or jasmine extract；Second extract is peony root extractive.

Preferably, the mass ratio of first extract and second extract is (700-1800): 1.

Second aspect of the present invention provides a kind of gel, the gel contain lower alcohol, thickener, acid-base modifier, it is non-from Composition described in sub- surfactant and first aspect present invention.

Third aspect present invention provides a kind of method for preparing gel described in second aspect of the present invention, this method packet It includes:

1) acid-base modifier is dispersed in water, is completely dissolved to obtain mixture a；

2) the second extract is dispersed in nonionic surfactant and obtains mixture b；

3) thickener is dispersed in water, is completely dissolved to obtain mixture c；

4) the first extract, lower alcohol are sequentially added into mixture c, is stirred evenly, then sequentially add mixture B, mixture a is to get the gel.

Fourth aspect present invention provides composition and second aspect of the present invention institute described in a kind of first aspect present invention Application of the gel stated in cosmetics, hair shampoo article.

Through the above technical solutions, the Material of gel provided by the invention is pure natural, appearance transparent is in light green, contains pearly-lustre Crystal grain, and have effects that moisturizing, anti-scytitis, anti-dandruff and itching-relieving, antipollution, oxidation resistant.

Detailed description of the invention

Fig. 1 (a) is the micro- sem observation pearly-lustre crystal grain figure of gel Z1, and Fig. 1 (b) is the micro- sem observation pearly-lustre crystal grain of gel D1 Figure, Fig. 1 (c) is the micro- sem observation pearly-lustre crystal grain figure of gel D4；

Fig. 2 (a) is the anti-dandruff Evaluation results of gel Z1, and Fig. 2 (b) is the anti-dandruff Evaluation results of gel D1；

Fig. 3 (a) is to test preceding itching of the scalp situation self-appraisal as a result, Fig. 3 (b) is using itching of the scalp after gel Z1 mono- month Situation self-appraisal result.

Specific embodiment

The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more New numberical range, these numberical ranges should be considered as specific open herein.

First aspect present invention provides a kind of composition, and the composition contains the first extract, the second extract and water； Wherein, on the basis of the total amount of composition, the content of first extract is 60-90 weight %, second extract Content is 0.05-0.3 weight %, and the content of water is 5-40 weight %；First extract is magnolia extract and/or jasmine Extract；Second extract is peony root extractive.

In the present invention, it is preferable that on the basis of the total amount of the composition, the content of first extract is 70-85 Weight %, the content of second extract are 0.05-0.2 weight %.In the composition, the first extract, second are extracted The weight summation of object and water is 100%.

The present inventor has found, by the way that the first extract and the second extract to be used cooperatively, have under study for action The effect of preferable moisturizing, anti-scytitis, and have effects that preferably anti-dandruff, antipruritic, antipollution, oxidation resistant.It is preferred that In the case of, the mass ratio of first extract and second extract is (700-1800): 1, institute can be further increased State moisturizing, anti-scytitis and the anti-dandruff effect of composition.

In the present invention, the magnolia extract, jasmine extract and peony root extractive can be commercially available, can also basis Prepared by method in the prior art, the present invention is not limited thereto.For example, the preparation method of the magnolia extract can be with It include: that fresh yulan is ground into slurries；The ethyl alcohol that volume fraction is 50-75% is added, is heated to 60-80 DEG C, stirring mentions 1-3h is taken, is filtered；Filtrate is decolourized, is concentrated, the magnolia extract is obtained.Jasmine extract and peony root extractive It can be prepared using similar method, this will not be repeated here by the present invention.

Preferably, the magnolia extract is in yulan flower extract, yulan leaf extract and yulan stem extraction It is at least one；The jasmine extract is selected from jasmine flower extract and/or jasmine leaf extract.

In the present invention, the gel refers to the transparency emulsion quality that can be applied at face, neck, hair or scalp Substance, be referred to as gel.

Preferably, on the basis of the total amount of the gel, the content of the lower alcohol is 1-8 weight %, the thickener Content be 0.05-3 weight %, the content of the acid-base modifier is 0.3-1.8 weight %, the nonionic surfactant Content be 0.1-3 weight %.

In the present invention, lower alcohol, thickener, acid-base modifier, nonionic surfactant and the present invention in the gel The weight summation of the composition is 100%.

Preferably, the lower alcohol in glycerol, 1,3-BDO, propylene glycol, sorbierite, pentanediol at least one Kind；The thickener is selected from least one of Carbomer981, carbomer 380, xanthan gum, carrageenan, tamarind seed glue；Institute It states acid-base modifier and is selected from least one of arginine, sodium citrate, sodium hydroxide, triethanolamine, monoethanolamine；It is described non- Ionic surface active agent is selected from Cremophor RH40, PEG-60 rilanit special, PEG-7 glyceryl cocoate, PEG-400 At least one of.

Preferably, the gel crystal grain containing pearly-lustre, and be transparent light green.Wherein, pearly-lustre crystal grain is to mention through the invention The composition of confession is aided with lower alcohol, thickener, acid-base modifier, nonionic surfactant and reacts the macroscopic of generation The natural particulate substance with pearly-lustre, not needing chemical pearling agent is added can generate.In the present invention, pass through by Magnolia extract and/or jasmine extract and peony root extractive and water are compounded according to specific dosage, and are aided with low Grade alcohol, thickener, acid-base modifier, nonionic surfactant, pearly-lustre crystalline substance can be obtained by not needing to be added chemical pearling agent Grain.

In the present invention, by by magnolia extract and/or jasmine extract and peony root extractive and water according to spy Fixed dosage is compounded, and is aided with lower alcohol, thickener, acid-base modifier, nonionic surfactant, divides it by each group Between coordinated, the gel being prepared has effects that moisturizing, anti-scytitis, anti-dandruff and itching-relieving, antipollution, oxidation resistant, And be pure natural, crystal grain containing pearly-lustre, appearance is transparent light green, can be applied to cosmetics, in hair shampoo article.

The present invention will be described in detail by way of examples below.In following embodiment,

The manufacturer of each raw material is shown in Table 1.

Table 1

The basic performance of gel is evaluated by following parameter:

Pearly-lustre feature: it is not natural that chemical pearling agent, which is added,.

Pearly-lustre stability: being placed under 50 DEG C of high temperature, 4 DEG C of low temperature, room temperature and different illumination conditions, using naked eyes and Micro- sem observation pearly-lustre stability.

Material color: changed using visual color and recorded.

The test method of color change: the weight Material such as weighing, and chromascope is used to carry out the measurement of Lab value.Color is different, Lab Value Data is inconsistent, Δ E < 1 and Δ E value is smaller, and parallel laboratory test Δ E variation less, is considered as the lotion of colour stable three times.

Colour stability: being placed under 50 DEG C of high temperature, 4 DEG C of low temperature, room temperature and different illumination conditions, is seen using naked eyes It examines color change and records.

Fragrance: different proportion Materials provides after senior news perfume Shi Pinxiang as a result, and marking.

Embodiment 1

1) in deionized water by acid-base modifier dispersion, it is completely dissolved to obtain mixture a；

4) the first extract, lower alcohol are sequentially added into mixture c, is stirred evenly, then sequentially add mixture B, mixture a obtains gel Z1；

Wherein, the additional amount of deionized water makes the total amount of gel be 100 parts by weight, the type and proportion of other each components (parts by weight) are shown in Table 2.

Micro- sem observation pearly-lustre crystal grain: being made tabletting for gel, is observed, is seen under 400 times of amplification using microscope It examines shown in result such as Fig. 1 (a).

Basic performance evaluation result is shown in Table 3.

Embodiment 2-5

Gel is prepared according to the method for embodiment 1, and the type and proportion of each component are adjusted, gel Z2-Z5 is obtained, Specific adjustment is shown in Table 2.

Basic performance evaluation result is shown in Table 3.

Comparative example 1-10

Gel is prepared according to the method for embodiment 1, and the type and proportion of each component are adjusted, gel D1- is obtained D10, specific adjustment are shown in Table 2.

Micro- sem observation pearly-lustre crystal grain: being made tabletting for gel, is observed under 400 times of amplification using microscope, right Shown in observation result such as Fig. 1 (b) and Fig. 1 (c) of ratio 1 and comparative example 4.

As seen in Figure 1, pearly-lustre crystal grain distribution is uniform in the gel being prepared in embodiment 1, crystal grain is tiny；And Pearly-lustre crystal grain distribution is uniform in the gel being prepared in comparative example 1, crystal grain is slightly larger, in the gel being prepared in comparative example 4 Pearly-lustre crystal grain distribution is uneven, crystal grain is larger.

Basic performance evaluation result is shown in Table 3.

Table 2

Table 3

Can be seen that by the data of table 2 uses gel provided by the invention to be pure natural, pearly-lustre crystal grain distribution uniformly, Crystal grain is tiny, and pearly-lustre has good stability, and appearance transparent is in light green, and colour stability is good, and fragrance is neither too strong nor too light.

Test case 1

Moisture-keeping efficacy evaluation

Made in specific region on the inside of forearm by test request using German CK keratoderma moisture content tester After the gel in comparative example and preparation example, moisture content of skin is measured respectively after 0h, 1h, 2h and 4h, the results are shown in Table 4, wherein Blank is that the test result of gel is not used.

Table 4

It can be seen that magnolia extract and/or jasmine extract in composition provided by the invention by the data in table 4 With peony root extractive with the use of synergistic effect can be played, the moistening effect of gel is improved.

By comparing gel Z1 and gel Z4 and gel Z1 and gel Z5 can be seen that by the first extract with it is described The mass ratio of second extract is (700-1800): 1, the moistening effect of gel can be further increased.

Test case 2

Antiphlogistic effects evaluation

Lipopolysaccharides is the main component of gram-negative bacteria cell wall, and it is thin that it can discharge a variety of inflammatories with activating macrophage Intracellular cytokine, therefore external inflammatory response model is established using lipopolysaccharides (LPS) stimulation mouse monokaryon-macrophage, sample carries out Intervene, and use dexamethasone for positive control, inflammatory factor IL-6 and TNF-α are measured using enzyme-linked immunization (ELISA) Horizontal variation, to inquire into the extracorporeal anti-inflammatory effect and anti-inflammatory mechanisms of sample.

It is tested using gel obtained in embodiment and comparative example as sample, test result is shown in Table 5, wherein blank For the test result that gel is not used.

Table 5

It can be seen that cell after the effect of LPS stimulant by the data in table 5, inflammatory factor IL-6 and TNF-α secretion Apparent increase, after gel effect provided by the invention, the decline degree that can reduce the secretory volume of inflammatory factor IL-6 and TNF-α is bright Aobvious to be greater than dexamethasone, and after the gel effect in comparative example, effect only quite or is not so good as positive control with positive control, Show that magnolia extract and/or jasmine extract are used cooperatively with peony root extractive and can rise in composition provided by the invention To synergistic effect, the antiphlogistic effects of gel are improved.

By comparing gel Z1 and gel Z4 and gel Z1 and gel Z5 can be seen that by the first extract with it is described The mass ratio of second extract is (700-1800): 1, the antiphlogistic effects of gel can be further increased.

Test case 3

Anti-dandruff and itching-relieving efficacies evaluation

Different degrees of dandruff, scalp pruritus subject eluted that (period is without using any using blank shampoo one week Other products relevant to anti-dandruff and itching-relieving), after the completion of the elution phase, different samples hair washing moisture or so half a head is used to have one's hair wash one month (wash within three days one, and at night have one's hair wash), daytime on day 1 respectively, the 7th day daytime, the 14th day daytime, the 21st day daytime, the 28th Its daytime carries out evaluation test.Anti-dandruff evaluation carries out the acquisition of dermoscopy mirror image using Denmark DermLab DOC-HR dermoscopy, As a result see Fig. 2, wherein Fig. 2 (a) is the anti-dandruff Evaluation results of gel Z1, and Fig. 2 (b) is the anti-dandruff performance evaluation knot of gel D1 Fruit；Referring concurrently to ten grades of point system ASFA of clinical medicine adherence dandruff, entire scalp is averagely divided into 6 regions (left and right Each 3 regions), it scores each region, total score is the sum of 6 region score values, tracks and records the situation of change of score value, comments Minute mark standard the results are shown in Table 7 referring to table 6；As a result antipruritic effect evaluation is shown in Fig. 3, wherein scheming using adjusting poor questionnaire form to be evaluated 3 (a) be to test preceding itching of the scalp situation self-appraisal as a result, Fig. 3 (b) is using itching of the scalp situation self-appraisal knot after gel Z1 mono- month Fruit.

Table 6

0 grade	Without dandruff
		1-2 grades	For the greyish white rough scales of small flakes
3-4 grades	As low as median size chip
		5-6 grades	With the loose big and thin chip being connected of scalp
7-8 grades	Big tackness chip
		9-10 grades	With the white thicker scales of skin that peel off to yellow of scalp close attachment

Table 7

Gel	1st day	7th day	14th day	21st day	28th day
						Z1	13.8	8.9	3.5	1.5	0.2
Z2	13.7	9	3.4	1.6	0.3
						Z3	13.6	8.8	3.5	1.4	0.2
Z4	13.5	9.3	4	2	0.5
						Z5	13.6	9.5	4.1	2.1	0.6
D1	13.6	10.4	6	3.4	1.2
						D2	13.7	10.6	6.3	3.5	1.3
D3	13.5	10.7	6.5	3.7	1.4
						D4	13.5	10.8	6.2	3.6	1.1
D7	13.6	10.5	6.1	3.4	1.2
						D8	13.3	12.8	9	6.6	4
D9	13.8	13	10	6	3.6
						D10	13.5	10	8.1	4.1	2.3

It can be seen that by the data in table 7 and mentioned using magnolia extract in composition provided by the invention and/or jasmine It takes object and peony root extractive with the use of synergistic effect can be played, improves the anti-dandruff effect of gel.

By comparing gel Z1 and gel Z4 and gel Z1 and gel Z5 can be seen that by the first extract with it is described The mass ratio of second extract is (700-1800): 1, the anti-dandruff effect of gel can be further increased.

As seen in Figure 3, gel provided by the invention has preferable antipruritic effect.

Test case 4

Antipollution efficacy assessments

By skin explant at 37 DEG C, the CO containing 5 volume %₂Sample is locally applied to skin to stabilization by culture in environment Skin explant, then at 37 DEG C, the CO containing 5 volume %₂It is cultivated 24 hours in environment, skin explant is dirty in 24 hours later (20 μm) of object BaP pollutions of dye, are then locally applied to explant for sample again, at 37 DEG C, containing 5% CO₂It is trained in environment It supports 24 hours, retains the immunostained for analysis that explant carries out gram labor fourth 1 and Ke Lao fourth 4, use the fluorescent optics of × 40 object lens Microscope and product dyed thereby filter carry out sections observation, describe slice state in detail, analyze result.It the results are shown in Table 8.

Table 8

Test case 5

Anti-oxidation efficacy evaluation

Using DPPH radicals scavenging method, stablize nitrogen free radical according to present in DPPH molecule, alcoholic solution is in dark purple Color, and have strong absorption near 520nm.In the presence of having free radical scavenger, the single electron in molecule makes its suction because of pairing Receipts fade away, and the electron amount that fading extent receives with it is at quantitative relationship, therefore, can be by measuring its maximum absorption wave Reducing for absorbance at long 520nm carrys out the anti-oxidation efficacy that quantitative analysis free radical scavenging ability measures sample.It the results are shown in Table 9。

Table 9

It can be seen that gel provided by the invention with preferable anti-oxidation efficacy by the data in table 9.

Test case 6

The test method of preservation challenge: sample is taken to dispense each 100g, one bottle of addition mixed cell, one bottle of addition mixing is very Bacterium is respectively placed in corresponding incubator, i.e. the sample of addition bacterial suspension is placed in 30-35 DEG C of incubator, and addition fungi is outstanding The sample of liquid is placed in 20-25 DEG C of incubator.Sample after inoculation is living by certain time interval sample detection in challenge process Bacterium number.Sample time is set to: (0 day), 7 days, 14 days, 21 days, 28 days immediately after inoculation.Corresponding culture medium is selected when sample detection It is detected.Detection method can refer to " checked operation regulation (yeast and mold) " and " checked operation regulation (total plate count) " It carries out.Gel Z1 is tested according to the method described above, test result is shown in Table 10.

Table 10

The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to Protection scope of the present invention.

Claims

1. a kind of composition, the composition contains the first extract, the second extract and water；Wherein, it is with the total amount of composition Benchmark, the content of first extract are 60-90 weight %, and the content of second extract is 0.05-0.3 weight %, The content of water is 5-40 weight %；First extract is magnolia extract and/or jasmine extract；Second extract For peony root extractive.

2. composition according to claim 1, wherein on the basis of the total amount of the composition, first extract Content be 70-85 weight %, the content of second extract is 0.05-0.2 weight %.

3. composition according to claim 1 or 2, wherein the quality of first extract and second extract Than for (700-1800): 1.

4. composition according to claim 1 or 2, wherein the magnolia extract is selected from yulan flower extract, yulan leaf At least one of extract and yulan stem extraction；The jasmine extract is selected from jasmine flower extract and/or arabian jasmine leaf mentions Take object.

5. a kind of gel, which contains lower alcohol, thickener, acid-base modifier, nonionic surfactant and claim Composition described in any one of 1-4.

6. gel according to claim 5, wherein on the basis of the total amount of the gel, the content of the lower alcohol is 1-8 weight %, the content of the thickener are 0.05-3 weight %, and the content of the acid-base modifier is 0.3-1.8 weight %, The content of the nonionic surfactant is 0.1-3 weight %.

7. gel according to claim 5 or 6, wherein the lower alcohol is selected from glycerol, 1,3-BDO, propylene glycol, mountain At least one of pears alcohol, pentanediol；The thickener is selected from Carbomer981, carbomer 380, xanthan gum, carrageenan, acid At least one of beans seed glue；The acid-base modifier is selected from arginine, sodium citrate, sodium hydroxide, triethanolamine, monoethanol At least one of amine；The nonionic surfactant is selected from Cremophor RH40, PEG-60 rilanit special, PEG- At least one of 7 glyceryl cocoates, PEG-400.

8. the gel according to any one of claim 5-7, wherein the gel crystal grain containing pearly-lustre, and be transparent light Green.

9. a kind of method for preparing gel described in any one of claim 5-8, this method comprises:

4) the first extract, lower alcohol are sequentially added into mixture c, is stirred evenly, then sequentially added mixture b, mix Object a is closed to get the gel.

10. gel described in any one of composition and claim 5-8 described in any one of claim 1-4 Application in cosmetics, hair shampoo article.