JP2005002057A - Material for beauty and health, containing extract of geranium robertianum - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a safe polyfunctional material for beauty and health, having excellent stability, and further having bleaching activities, antioxidant activities, activities for preventing the aging of the skin, antiinflammatory activities, and the like. <P>SOLUTION: A bleaching agent, an antioxidant agent, an agent for preventing and ameliorating the aging of the skin, an antiinflammatory agent and a cosmetic composition contain an extract obtained from Geranium robertianum. The material of this invention has the polyfunctional beautifying activities such as melanin formation-inhibiting activities, lipid peroxide formation-inhibiting activities, collagenase production-inhibiting activities, hyaluronidase-inhibiting activities and histamine release-inhibiting activities. The cosmetic composition obtained by applying them has extremely superior effects on the prevention of the aging of the skin and the amelioration of atopic dermatitis such as amelioration of liver spot, freckle and dark complexion, and amelioration of eczema, rough skin, wrinkle, tenseness and slackening of the skin, and an antiinflammatory and antiallergic action such as the prevention and amelioration of itching. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

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〔試験８〕使用試験１
前記実施例の化粧料組成物の使用テストを行った。すなわちシミ・ソバカス、色黒で悩む人（１０名）、湿疹等で悩むアトピー性皮膚炎の人（６名）、肌荒れ（４名）、皺・肌のたるみで悩む人（１１名）をパネラーとし、毎日、朝と夜の２回、洗顔後に処方例１の乳液（乳液１）の適量を顔面に１ヶ月間塗布することにより行った。対照品（乳液２）には、乳液から本発明のヒメフウロ抽出液を精製水に置き換え同様な方法にて処方したものを用いた。尚、パネラーには乳液の内容を知らせることなく、摘要箇所を２カ所決定し、それぞれ乳液１、乳液２を間違いなく塗布し比較評価する方法で行った。結果は表１の通りで表中の数値は有効と答えた人数を表す。
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【表１】

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〔試験９〕使用試験２
前記実施例の顆粒浴用剤Ａの使用テストを行った。すなわち肌に張りのない人（６名）、浴後背中のカサツキやかゆみを感じる人（１５名）をパネラーとし、１ヶ月間毎日浴用剤入りの入浴を試み、アンケートを求めた。結果は表２の通りで表中の数値は人数を表す。
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【表２】

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表１，２のとおり本発明のヒメフウロ抽出物を配合した各化粧料組成物はシミ・ソバカス，色黒の改善といった美白作用、肌荒れ、シワ・ハリ・肌のたるみの改善といった皮膚の老化防止及び湿疹等のアトピー性皮膚炎の改善、カユミの防止・改善といった抗炎症・抗アレルギー作用に極めて顕著な効果を有することが確認された。
【０１４３】
【発明の効果】
本発明によるヒメフウロ抽出物には、メラニン生成抑制作用、過酸化脂質生成抑制作用、コラゲナーゼ産生抑制作用、ヒアルロニダーゼ阻害作用、ヒスタミン遊離抑制作用といった、多機能な美容的作用を有する素材であり、安全かつ安定性にも優れている。これを応用した本発明の美白剤，抗酸化剤，皮膚老化防止・改善剤，抗炎症剤，化粧料組成物は、シミ・ソバカス，色黒の改善、湿疹、肌荒れ、シワ・ハリ・肌のたるみの改善といった皮膚の老化防止及びアトピー性皮膚炎の改善、カユミの防止・改善といった抗炎症・抗アレルギー作用に極めて顕著な効果を有する。
【図面の簡単な説明】
【図１】本発明のヒメフウロ抽出物のチロシナーゼ活性阻害作用を示す図である。
【図２】本発明のヒメフウロ抽出物のメラニン生成量を示す図である。
【図３】本発明のヒメフウロ抽出物の過酸化脂質生成抑制作用を示す図である。
【図４】本発明のヒメフウロ抽出物のコラゲナーゼ（ＭＭＰ−１）産生量を示す図である。
【図５】本発明のヒメフウロ抽出物のヒアルロニダーゼ活性阻害作用を示す図である。
【図６】本発明のヒメフウロ抽出物のヒスタミン遊離抑制作用を示す図である。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to the development of a beauty / health material having excellent effects on whitening, antioxidation, prevention of skin aging, anti-inflammation, and the like, and its application. More specifically, it contains a safe and stable extract obtained from Himefuuro, which is excellent in melanin production inhibitory action, lipid peroxide production inhibitory action, collagenase production inhibitory action, hyaluronidase inhibitory action, and histamine release inhibitory action. The present invention relates to the development of beauty and health materials for the purpose of whitening with oxidation, skin firmness and elasticity, anti-inflammatory action, and application to cosmetic compositions.
[0002]
[Prior art]
Traditionally, whitening agents that can control skin pigmentation such as spots (liver spots), buckwheat (sparrow eggs spots) or skin blackening caused by UV exposure have been developed as wrinkles, sagging, keratinization This is one of the most important issues in the cosmetics field, along with prevention and improvement of skin aging and hair growth, etc., and active studies have been continued.
[0003]
Skin pigmentation is simply caused by the high accumulation of melanin pigments globally or locally in the skin as a result of the production of melanin pigments in the skin by various external factors. That is, it has been considered that skin pigmentation can be controlled by inhibiting or controlling this in vivo reaction in some form, and conventionally, for example, inhibition of melanin producing enzyme activity, Lightening due to degradation, etc., and more recently, regulation and suppression of gene expression of melanogenesis-related enzymes, suppression of intracellular or intercellular signaling that controls melanogenesis, suppression of activation of melanocytes themselves, which are melanocytes Molecular biological studies have also been studied.
[0004]
In the cosmetic field, based on the above-mentioned knowledge, for example, ascorbic acid or its derivative, kojic acid or its derivative, cinnamic acid derivative or chromone derivative, resorcin glycoside, amine derivative, chlorogenic acid or its derivative, unsaturated Compounds such as fatty acids, flavanones, catechin derivatives, arbutin, leguminous plants such as licorice and kudzu root, liliaceae plants such as enchanting beetle, janohige, asteraceae plants such as crab ears, dianthus and chamomile, and gramineae such as rice Plants, myrtaceae plants such as clove, cucurbitaceae plants such as vines, hangae, aloe, camellia plants such as tea, various plant extracts such as algae, and animal / microbe-related components such as lactoferrin and lactoferrin degradation products Various whitening agents have been developed so far (see, for example, Non-Patent Document 1). However, with regard to these whitening agents, neither the stability of the whitening effect over time in the cosmetic preparation nor the strength of the whitening effect itself has been satisfactory for the demands of consumers and the like.
[Non-Patent Document 1] Noriyuki Omori, FRAGRANJO JOURNAL Special Issue, No. 14, 1995, 118-126
[0005]
In recent years, causal relationships with free radicals and active oxygen have been taken up as factors that oxidize biological components, and the unfavorable effects caused by these have been emphasized. For example, free radicals and active oxygen are generated in the body, which degrades or cross-links biological tissues such as collagen, and oxidizes skin lipid squalane and cell membrane lipids to reduce the function of cells, causing wrinkles, tarmi and rough skin. It is pointed out that it exacerbates etc.
[0006]
It is known that hyaluronidase is activated during inflammation and lowers the molecular weight of hyaluronic acid, thereby reducing skin elasticity and causing aging such as wrinkles.
[0007]
The ultraviolet rays that cause the generation of reactive oxygen species also activate the action of elastase that specifically acts on elastin and collagenase that acts on collagen, such as MMP-1, thereby promoting the degradation of elastin and collagen, It is said that it will weaken its elasticity and elasticity. The action of elastase and collagenase is activated by aging and brings about similar results. That is, if the amount of new collagen or elastin supplemented with aging decreases or the degradation of elastin is accelerated by UV stimulation, it becomes difficult to maintain the structure involved in maintaining the elasticity of the skin. It is thought to be in an aging state.
[0008]
Therefore, for the purpose of use for the prevention and improvement of skin aging, substances having lipid peroxide production inhibitory action, collagenase production inhibitory action, hyaluronidase inhibitory action, etc. were searched, and with regard to lipid peroxide production inhibitory action, tocopherols As well as those using ascorbic acid and its derivatives and SOD, rosemary, salvia, allspice, peony, mugwort, asenya, abalone, peach leaves, etc. have been found (for example, see Patent Document 1, Patent Document 2, etc.) However, their application as a cosmetic agent has been proposed, however, none of them were satisfactory when blended in cosmetics because of problems in stability and safety.
[Patent Document 1] Japanese Patent Laid-Open No. 61-24522
[Patent Document 2] Japanese Patent Laid-Open No. 02-243632
[0009]
Furthermore, regarding the collagenase production inhibitory action, extracts of Thymus plants, Acacia yak, cocoon, walnut and peppermint extracts (see, for example, Patent Document 3, Patent Document 4 and the like), and for the hyaluronidase inhibitory action, peonies, aurens, Genokosho, Efficacy has been found in Jiuyu, Ages, Asenyaku, Pinrouji, black tea, green tea, Mimsopus elenge, Eugenia jambonara, Sakhaline deca, chicken blood wisteria, sasen crane grass, tablina, etc. (for example, Patent Document 5, These extracts are also unsatisfactory because of their stability and feeling of use.
[Patent Document 3] JP-A-11-79970
[Patent Document 4] Japanese Patent Application Laid-Open No. 2000-159631
[Patent Document 5] Japanese Patent Application Laid-Open No. 01-128933
[Patent Document 6] Japanese Patent Laid-Open No. 02-11520
[Patent Document 7] Japanese Patent Laid-Open No. 06-80553
[0010]
In addition, skin inflammation caused by ultraviolet rays is a cause of rough skin, and an external preparation for skin that reduces the inflammation and improves rough skin is desired. As one of the treatment methods, there is a method of suppressing the release of histamine, which is a inflammatory substance that occurs during inflammation, and steroids are used, but the risk of side effects cannot be denied.
[0011]
In view of the above, a multifunctional beauty / health material such as whitening, antioxidant, prevention of skin aging and anti-inflammatory action, which is safe and excellent in stability, is desired.
[0012]
[Problems to be solved by the invention]
In view of such circumstances, the present inventors have whitening action, antioxidant action, skin aging prevention / improvement action, anti-inflammatory action (melanin production inhibitory action, lipid peroxide production inhibitory action, collagenase production inhibitory action, hyaluronidase inhibitory action, It is an object of the present invention to provide a multifunctional beauty / health material having a high safety and stability, which has both a histamine release inhibitory action and a substantially high utility value, and to provide a cosmetic composition to which it is applied.
[0013]
[Means for Solving the Problems]
The inventors of the present invention have conducted screening on various plant extracts for various evaluation systems relating to beauty and health as described above. In the process, the extract obtained from Himefuuro, which is a new ingredient in the cosmetics field, is effective for any action, is safe, and has very little occurrence of starch, precipitation, discoloration and odor. We found that it could be a multifunctional beauty and health material with stable properties.
[0014]
That is, the present invention provides a whitening agent, an antioxidant, a skin aging preventive / ameliorating agent, an anti-inflammatory agent, and a cosmetic composition containing a himefuuro extract. Furthermore, by containing these whitening agents, antioxidants, skin aging prevention / improving agents, and anti-inflammatory agents, a cosmetic composition excellent in skin-beautifying action for maintaining healthy skin or scalp is provided.
[0015]
DETAILED DESCRIPTION OF THE INVENTION
Himefuuro used in the present invention is a plant belonging to the genus Fusoso, Geranium robertianum L. (herbal medicine name: blue caquine (cat leg mark)), flower, ear, stem, leaf, branch, branch leaf, rhizome, Roots, seeds or whole plants are used, but preferably whole plants are used. In addition, G. carolinianum L., G. erianthum DC, G. eristemon Fisch. Var. Reinii Maxim. wilfordii Maxim. G. sibiricum L. In addition, G. shikokunumum Matsuura, Ezo fuuro (G. yesense Fr. et Sav.), Hakusan Fuuro (Var. Nupponicum Nakai), etc. can also be used.
[0016]
Examples of the method for producing the extract of himefuuro according to the present invention include, for example, pulverizing a dried product of himefuuro, adding 5 to 20 times the amount of the extraction solvent (water, organic solvent or a mixture thereof), and at least 3 days at room temperature. The extract obtained by allowing to stand and filtering is used, or the extract is concentrated (may be dried).
[0017]
Another production method was obtained by adding an extraction solvent (water, an organic solvent or a mixture thereof) to Himefuro as described above and digesting for a certain period of time, or performing warm extraction at the boiling point of the solvent and then filtering. The extract is used or the extract is concentrated (may be dried). Extraction conditions include normal pressure, normal temperature, high pressure and low pressure. In addition, it is possible to use a supercritical extraction method using a supercritical fluid using carbon dioxide, carbon dioxide gas, or the like.
[0018]
As an extraction solvent, water, lower alcohol such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or the like, hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4 -Butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight 100 to 10 Polyhydric alcohol or water-containing polyhydric alcohol, acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, In various organic solvents such as ruene, acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.) prepared as appropriate It is desirable to use one or a mixture of two or more selected from. However, when it is not preferable to contain a solvent depending on the application, water alone may be used, or ethanol that can be easily removed after extraction may be used alone or in any mixture with water.
[0019]
The extract may be subjected to a simple purification treatment by activated carbon treatment, adsorption resin treatment, ion exchange resin treatment or the like as long as it does not cause a significant decrease in these effects as required. Furthermore, the above extract and dried extract can be used as they are, or any auxiliary agent, for example, various excipients such as starch and lactose can be added, and mixed with a solvent such as ethanol. Needless to say.
[0020]
In addition, the above-mentioned extract can be used as a whitening agent, an antioxidant, a skin aging preventive / ameliorating agent, and an anti-inflammatory agent.
[0021]
In the product of the present invention, the Japanese black extract is contained in a concentration range of 0.0001 to 10% by mass, preferably 0.001 to 5.0% by mass (hereinafter referred to as%) as a solid content. In the case of an extract, it is used in an amount equivalent to this dry matter. Moreover, in the case of a bath agent, the addition amount may be set so that it is poured into 200 to 300 L of bath water to obtain a similar concentration.
[0022]
The cosmetic composition according to the present invention is 1) topical or systemic skin cleanser or skin cosmetic, 2) medicinal and / or cosmetic preparations applied to the scalp and hair, and 3) pour into bath water. 4) Deodorant / deodorant for human body, 5) Skin sticking sheet, cosmetic sheet, cosmetic cotton, sanitary goods, sanitary cotton, wet tissue, etc. , Capsules, powders, granules, solids, solutions, gels, bubbles, emulsions, sheets, mists, sprays, etc.
[0023]
Specifically, basic cosmetics such as lotion, emulsion, cream, ointment, gel, lotion, oil, pack, mist, facial cosmetic sheet, shaving agent, facial cleanser, skin cleanser, shampoo, rinse , Hair treatments, hair preparations, perms, hair arts, hair dyes, hair cosmetics such as hair growth and nourishing hair, makeup cosmetics such as foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, skin Deodorant, antiperspirant, bathing agent etc. are raised.
[0024]
In addition, it means beauty and health-oriented foods, beverages, and oral preparations in general. Ampoule, capsule, pill, tablet (pellet), powder, granule, solid, liquid, jelly (gel) or air bubble And so on. Specifically, nutrition supplementation, nourishing tonic, recovery from fatigue, improvement of body structure, whitening, skin beautification, anti-acne, beauty hair, hair growth / hair growth, anti-allergy and other beauty / health-oriented foods and beverages, gums, candy, Taste foods or beverages such as yogurt and soft drinks are raised.
[0025]
In addition to the above essential components, the product of the present invention can be produced by arbitrarily selecting and using the components and additives exemplified below within the range not impairing the effects of the present invention. The content in the preparation is not particularly limited, but is usually preferably 0.0001 to 50%.
[0026]
(1) Various fats and oils
Avocado oil, almond oil, fennel oil, egoma oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea Fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard , Squalene, squalane, pristane or hydrogenated products of these oils and fats (hardened oil, etc.).
[0027]
(2) Wax
Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, etc.
[0028]
(3) Mineral oil
Liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax, etc.
[0029]
(4) Fatty acids
Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, Synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.
[0030]
(5) Alcohols
Synthetic alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and other natural alcohols, 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.
[0031]
(6) Polyhydric alcohols
Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol Pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.
[0032]
(7) Esters
Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate Dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.
[0033]
(8) Metal soap
Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, etc.
[0034]
(9) Gums, sugars or water-soluble polymer compounds
Gum arabic, benzoin gum, danmar gum, guaiac gum, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or esters thereof, trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, Carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan to which alkylene (C2-C4) oxide such as ethylene oxide is added, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorus Oxidized chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, potassium Boxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethyleneimine and the like.
[0035]
(10) Surfactant
Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkylamine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid Type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Agent, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants (natural surfactant, protein Hydrolyzed derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants Etc..
[0036]
(11) Various vitamins
Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), Pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2 ), Cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin 3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.
[0037]
(12) Various amino acids
Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine And amino acid derivatives such as sulfate, phosphate, nitrate, citrate, or pyrrolidone carboxylic acid.
[0038]
(13) Various additives derived from plant or animal materials
These are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, washing, hydrolysis, fermentation, purification, pressing, extraction, fractionation, filtration, drying, pulverization) , Granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization and the like are arbitrarily selected and combined), and may be arbitrarily selected from various materials.
[0039]
The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol , One kind selected from various organic solvents such as lower alcohols such as isobutanol or hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or hydrous polyhydric alcohols, acetone and ethyl acetate Alternatively, it is desirable to use a mixture of two or more. However, when it is not preferable to contain an organic solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.
[0040]
In addition, when using additives derived from plant or animal-based ingredients for systemic or topical external preparations and cosmetics, it protects skin and hair, moisturizes, improves touch and texture, imparts flexibility, and stimulates Relaxation, stress relief by fragrance, cell activation (cell aging prevention), suppression of inflammation, improvement of skin and hair quality, prevention of rough skin and its improvement, hair growth, hair growth, hair loss prevention, imparting gloss, cleansing effect, In addition to cosmetic effects such as fatigue relief, blood flow promotion, and warm bath effects, effects such as flavoring, deodorization, thickening, antiseptic, and buffering can also be expected.
[0041]
In addition, in food and drink, nutritional supplementation, fatigue recovery, tonicity, cell activation (cell aging prevention) and other healthy and cosmetic effects, as well as improved taste, color tone, aroma, gloss, stabilization, thickening, It can be used for antiseptic purposes. In addition to this, various cosmetic and pharmaceutical effects of each of the known raw materials are expected, and by combining these, the intended effect can be promoted or multifunctional. It is also possible to make the product expected to be effective.
[0042]
Specific plants (herbal medicines) used as raw materials include, for example, almonds (Peach), Ai (Aiba), Aokazura (Seifu Fuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Akatsuki), Aotsu Rafuji , Aotenma, acacia, red ginger, red spruce “fruit”, red clover, red grape, red ginseng (logwood), red wrinkle (red buds), red crested or red crested or reddish (root), red crested or reddish (ground yellow), Agi (Aoi), Aki larch, Akinire (crusted skin), Aguay Guassou, Aguahe (Omiten coconut palm), Akebei (Kitsu), Asa (Asakojin), Marubaasagao or morning glory (Chicken), Hydrangea (hydrangea), Ashitaba (Tomorrow), Azuki (red bean), Asunaro, Acerola, Asen Ku (Asen Yaku), Athira (Shokuyo Kanna), Anise, Abiu, Abiurana, Brassica, Abemaki "Fruits", Avocado, Ama, Achacha (Amacha), Achacharu, Amadokoro (Tamatake), Amana (Kojiko), Amaranthus (Ayuyu, Hagateto, Higegateto, Senninkoku, Sugimorigateto, Hosoaogeito, Aogateto, Haribiyu, Aozulan, Amaranthus hippochondriax), Amigasayuri or Baimo (shellfish mother), Aristolomeria (Yurizuisen), Alcana (Arrouna) , Altea, Arnica, Alpinia or Katsudai (Suzukuku), Aloe (蘆薈), Aloe Vera, Angelica, Apricot or Honanzu (Anzujin), Ansokkou (benzoic incense), Yellow support, Igakozorina (Gall head) , Ikarisou or Yatsuma Taikiso (Japanese Yakukaku), rush (Ginseng grass), Japanese knotweed (Tiger root), Yew (first place), Strawberry, Fig (no flower "fruit, leaf"), Ichihatsu (first), Ichibibi (winter lion) ), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo "seed, leaves"), Itohimehagi (dianthus), Carob, Tuna (Telexi), Inubiyu (Honagainubiyu), Rice "Seeds, seed coat", Inondo "seed", Ibukizasou, Nettle, Ylang Ylang, Iwa Tobacco (Iwabuchi), Iwahiba or Iwamatsu (Makimochi), common bean, oolong tea, fennel (mud), wheat (Chibusanoki), Ukiyara (three-ridges), Uguisukagura "fruit", Japanese fennel, turmeric ( Ugly), Duckweed, Usubasaicin or Keirinsaishin or Oshii Ryusaishin (thin spicy), Usbunia mushrooms, Usbenitachia mallow, phalaenopsis, crabs (summer hay), Udo or Shishido (Alive, Independent, Tang Dynasty), Unyadegato (Uncaria, Cat's Claw), Uba tea, Ume (Umecha "seed, pulp" ”), Vulgaris, Rumors (Culps), Unsumikan (Chelsea), Unboku, Estragon, Ezoukogi (蝦 夷 5ka), Ezo-sulan-ran, Echinashi (Horaxa barrengiku), Enishida, Enokitake (Samurai), Ebisugusa or Cassia Toshiaki ), El Campre, Elderberry “fruit”, Elemi, Elingi or Pre-Lotus Elinji, Enju (Summer, Satsuma Rice), Pea, Ogi or Kibanaogi (Yellow Twilight), Naruko Yuri or Kagakuruma Naruko Yuri (Yellow), Ohisanoyuki Is Sasanoyuki, Oren (Huangren), Ogata Houken, Okarasuuri (Karokon), Oguruma (Civil), Otsutsu Rafuji (Prevention of Self), Psyllium (Vehicles, Precarious Grass), Great White Thistle (Luzhou Leak, Bald Eagle), Toucan (Lion), toucan cactus, large-scale okera or pokera (white moth), large-scale beetle (banaba), large-scaled shrub "fruit", large-sized bamboo shoot, large-scaled shrimp (cereal essence), large-sized catechu, large-scale hawthorn or large-scale moth (Barley), Oka, Okazeri (snake bed), Okra "fruit", Oguruma (turnover), Oguri higotai (Zhengzhou leakage, indigo head), Panax ginseng or Tochibaninjin (carrot), Hypericum pertussis Hypericum (brother cut grass), Odorikoso (Continued), Onamomi (Bird), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Onino Yagara (Tempa), Onyuri or Sasayuri or Hakatayuri (Yuri), Onoelan, Ononis, Halibut Soy sauce), Oyuko, Dutch mustard (watercress), Dutch jellies, Dutch ville, Dutch honey bees, Olives “fruits, seeds, leaves”, oregano, orange “fruits, peels”, silkworms (ripening yellow), cacao “fruits, peels” , Seeds ", Oysters (Kaki" Leaf "), Oyster Kazura (Kyoto Kaoru), Kakidoshi or Kantorisou (Lotus), Kakiran, Gaku Hydrangea, Cassia, Casino oyster (Salmon" Fruit "), Gajutsu (Kaki), Oak wrinkles, oak leaves, cascarilla, cascara grada, gypsophila, gypsophila, crab Kaniwa, carnation, valerian, hippopotamus, birch bamboo, birch or fern birch (white birch), gerbera, pumpkin, kapokonyoki "seed", kahoku sansho (蜀椒), gama (cage yellow), chamomile or roman chamomile, chamomile ( Tsutsumushi), Cam Kam (camo duck), Carraguwa or Yamaguwa (mulberry camellia), Collar, Karaku salmon man, Calla cucumber or Chinese cinnamon (Wang mackerel), Crows bichaku (half summer), Oats, Guarana "seed", Calahoo (Kohpak), Karaya, Garyu , Karin (Kiso), Garcinia, Kawamidori, Kawara Psycho (Delung rape, tranquilized white grass), Kawajisha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawara Nadeshiko (Soba, buckwheat), Kawaraninjin (blue strawberry), Kawara mugwort (茵?蒿), kansui (sweet candy), licorice (licorice), cantalara, candelilla, kanto, canna, kanran, raspberry (Ezo strawberry, Dutch strawberry, shrimp strawberry, nava white strawberry, maple strawberry, European raspberry), kiwi "fruit, leaf", kikarasuuri (Korone), Kyokyo (Kikyo, Kikyo-root), Chrysanthemum, Chrysanthemum, Chrysanthemum, Kikutaniku, Kisage (Kashimi), Gishigishi (Yotei), Kijitsu (Kakimi), Kizuta, Kidachi Aloe, Kidachihakka, Kina , Kinona (Cincona, Red cypress), Quinoa (Quinoa), Yellowfin, Yellowfin, Gymnema sylvestre, Kimenkaku, Cabbage, Cabbage "Immature fruit", Caraway, Cucumber, Gyoryu (Nishikawa willow, Taiyanagi), Kiraja Saponaria, Kiraya, Kiransu (Kinza Kosaku), Kumquat "fruit", Kinkiju, Ginseikai, Kimbusen, Kimma, Kimizukiki (Sentsukakusa), Kinran, Ginlan, Kinryohen, Guapaba Vermelha, Guava "Fruit", Guayule, Quercus Infectria (Cured) , Kugenumaran, wolfberry (bamboo shoots, coconut leaves, cocoon leaves, ground bones), Kusasugikazura (Tenmon winter), kudu (kudzu), camphor, gooseberry "fruit", carrot carrot (yellow flower bud), cutiti river, gardenia ( Yamakiko), Kunugi (Kusou Sou), Kupuas, Kubeba, Kumazasa, Kumatsura (horse whip grass), Clara (bitter), Cranberry "fruit", Chestnut "seed, fruit, astringent skin", Kurukurigo Ratifolia "Fruit", Grapefruit " Fruits and leaves ", buckthorn, black spider (required) Kameba Hiki Koshi or Kurobana Hiki Koshi or Hiki Koshi (prolonging grass), cloves (clove, clove), gumbai nazuna (sekimei, budgerigar), keigai (butterfly, cocoon), celosia (chicken flower, hen crown), gekkavidin, bay bay Sartorii roses (Soil, mountain return), Gentiana, Gennoshouko (Oldgrass grass), Kemponashi (Kigushi), Kokisekoku, Kushimikan (Koji, Tachibana, Obenimikan, Fukurican, Sagamikouji, Ponkan, Santara (Tachibana bark)) Moon flower), Kousuihakka, Kozo "fruit", Kocha (tea), Kouhone (riverbone), Kohon (Tsubakimoto, Karasumoto), Koryang, Koryokukyo (Kora), Cilantro "fruit", Koouren (Huo Ren), Koganebana (Huang Gong), Cowberry (Etsutachibana), Coco "fruit", Goshuyu (Kureo), Gosho strawberry (Golden bonsai), Pepper (Pepper), Cosmos, Copaiba balsam, Coffee "Seeds, leaves", Kofukisarokoshikake (plum infestation), Kobushi or magnolia (Spicy rice cake), burdock (beef bowl, beef eggplant), kobotan eel, sesame (sesame seeds), sesame seedling (genus ginseng), trash beet (gomiko), sakanekazura or binankazura or matsubusa, wheat (wheat), rice or rice koji "red rice cake, white rice cake" , Rice oil, cola acuminata “seed”, cola bella “seed”, coleus forskori, colony llya, fenugreek “fruit”, colombo, conzurango, kombu, konjac, comfrey (candid grass), sisal (sisal asa), Cyhailan, Sakakaneran (Ezosakakaneran), Sasima button button or Sina button button Cinnamon ginseng, cherry (Oshima cherry, Yamazakura, Oyama cherry, Edhigashi, bean cherry, Miyaza cherry, Yoshino cherry, Takanezakura, Kasami cherry, Kohigan, Satozakura, Kanzakura "leaves, flowers, fruits, bark (cherry bark)"), Cherry, Pomegranate, Sasa, Sababaginran, Sasanka, Saddle Moda (Sawamata), Sweet Potato, Sugarcane, Sugar beet, Sunflower jujube (Acanthoni), Saffron (Sanban Flower, Western Safflower), Sapodilla, Sapotea Marillo, Zabon "Fruit", Sabon Sou, Salmon "Fruit", Sarah Sashima (Sesame), Salamander (sand sashimi sashimi), Salvia (Sage), Sagaki Kyo (mountain vegetables), Sawagurumi (Yamamoko), Sangaku cactus, Sangre de Grado (croton), Sangikuyoso, Sun Ginseng (37 ginseng), Sanshuyu (Yamamuro), Sansho (Yamamuro), Sandskon (Yamadone), Shia (Kalite), Shiyanaki (fruit), Shiitake (Shizushi), Zion (purple potato), Sikakuma, Jikitaris, Shikunshi (Amiko), Perilla or Aojiso, Chilemiso or Katamenjiso (Shiso leaf, Shiso), Rosewood, Shinanoki, Shinohonoki, Shirarenyo (ream), Shimeji (Hinshimeji, Shakashimeji, Hatake-Shimeji, Oshiro-Shimeji, Boshi-shigeji, Honjimeshishi , Shimoklen (Powder), Shimotsuke, Potato, Peonies (Shakuyaku), Shajin (Shasan), Jasmine (Matsurika), Janohige (Marimon Winter), Dwarf Cowpea, Shukukonkasamisou, Shukushamitsu (Sanjin, Shredded Sand) , Juzdama, Shurro "fruit", Shunra Ginger, ginger, ginger (Ginger), ginger hydrangea (Tsuneyama), ginger (Sardine, Sone), Shozu "fruit", shirakashi "seed", silane (Bikkyu), rosy butterfly "seed", white clover (clover), white cherry (Chicken bone grass), white squirrels (scented squirrels), Shirobanatsuta "flower", Shirobanarupin, Shirominanten (southern Tenshin), Cinchona sill bra, zinchoge (Mizuka, Suzuka flowers, Shichohana), cinnamon, cinnamum cassia (cinnamon) , Watermelon (Sairan), honeysuckle (gold and silver flowers, Shinobu), sorrel (acid mimic), swimberry "fruit", star apple, stevia, strawberry "fruit", succulent (Xulong), sugina (question), purslane (horse teeth) Ken, horse tooth candy), plum "fruit", sulgaran (Oran) , Japanese larch, Japanese larch, Japanese lizard, Japanese walnut, Japanese hawthorn, Japanese cypress, Japanese dandelion, Japanese horse chestnut (maronier), European pear "fruit", Japanese yellow snow, American elder, Japanese juniper , Juniper), Achillea millefolium (milfoil), Rose rose, Papilio butterfly, Mistletoe spruce, Atlantic mint or Atlantic mint Hondokukoku, Butterflies, Derbybium, Ishibuchi), Cedron, Blossoms, Hirosanega, Se Moth, celery, celery, nematode (river cucumber), sensinren (centripetal ream), sendan, sennin cactus, senna "fruit, leaf", sennin (Otsuka), senburi (medication), senboku, soka (grass) , Elephant chow, buckwheat, buckwheat “seed”, some potato, broad bean, daiou (daihuang), radish, soy, daidai (orange peel, fruit), takasagorurihigotai (southeast indigo sashimi), takasaburo (song lotus), takatodai ( Daegu), Takara-babi (dark spine), dark sweet cherry “fruit”, hollyhock, red-headed pearl millet (thyme, perilla), tachidokoro (hikai), tachiyanagi, tamarind “seed”, onion, ramshiba (hot pepper), taranoki “fruit, Leaf, root bark ", Tarayo (Ooba Fuyu-blue, Ichiha tea, bitter tea, bitter tea), Dahlia (tenji button), Tarwi, Tankimi, Tanshichiwa, Tanjin, Dandelion or Shirobana Dandelion or Moco Dandelion, Danmaru, Cherry "fruit", Chigaya "fruit, root, bud", Chikusetuninjin (Bamboo Ginseng), Chicory, Chancapiedra (Kantachi Kumiso), tulip, chocolate knot, darts thistle (artichoke), ginkgo biloba (daihuang), ginseng (蕪 夷), ginseng (艾艾), choreimaitake (猪苓), chorogi, tsukimisakane, tsukushikananeran, Tsukuritake (mushroom), Tsuchiakebi, camellia, camellia, clover (lacquered weed), camellia (duck-weed), Tsuruzuki (red bean), Tsurutsukichibi, Tsurudukudami (what neck rice cake), Tsuruna (Apricot), Tsuruninjin (four leaf ginseng), Turtle bean Tsuwabuki, Deiko, Teuchigurumi, Duberry "fruit", Tengusa, Tencha (glazed tea), Tendai Yaku (glaze), Toga (winter coconut), Toka moth, Todashi (banban), Touki (Toyaki), Tokinsenka (Marigold) ), Horned beetle, tounabena (river cut), corn or corn hair (southern cocoon), red scabbard (woman Sadako), turpentine or ginseng (dragon gall), toksa (wood bandits), dokudami (ten drugs), tokon ), Toshishi or mamedaoshi or pear quail, eucommia (bark "bark, leaf, root"), ash (crust), tomato, tragacanth, triacanthus "seed", truffle (agaric), turkey kyoto, tormentilla, dronoki, troloioi Ton bean, Neiseria berry "fruit", Potato or yam (mountain medicine), nagii kada (butcher bloom), naginata kouju, nazuna, rapeseed, jujube or vertical bean (sword bean), jujube, jujube (large potato), naniwaibara (gold cherry tree), navena (continuous), nameko , Peanut (peanut), Nanten (southern berries), namban karamushi (snacks), scented mire, nygaki (bitter tree), sagebrush (bitter melon), nikuzuku, kei or nikkei or ceylon nikkei or yabuni kei (cinnamon) or keishi (katsura) Branch), Flyingbird, leek, elderberry (bone, fruit, flower, stem, leaf), garlic (large cocoon), nurde (penta), leek, nemkin or nebu or nevi or nemurokin or digokubana (cheer) , Noazami (Daisetsu), Neubara (National), Nozenkazura (Rinka Hana), Nogateto, Noko Girizo, Nodake (frontal cucumber), Novara, Peach, Pineapple “fruit”, Hibiscus (Busouge, Furibususouge, Roselle), Hilindo, Hauchiwa, Pau Dorse, Hakama Labosi (bone crushing), Hakkayumatou, Hakusantori, Hakusen Ringworm skin), hakuru berry "fruit", chickweed (breeding), hazelnut (coconut), ashridokoro (roth root), basil, lotus (lotus, lotus meat, lotus), parsley (holland jellied), hadakamigi, batata, wasp or mushroom (Bamboo camellia), patchouli, mint (thin load, light leaf), yellow peas, yellow barley (Yokuinin), Hanasuge (knowing mother), bananas, hana hakka, hanabishi (shitsurishi, shitsutsuri), vanilla bins, papaya, hakogusa (bamboo grass), Pahalobobo, hub “whole plant, stem, leaf”, paprika, anemone , Hamago or honey bee moth (bamboo lion), hamasuge (katsukiko), terrestris (satsuma lion), hamanas (maikai flower), kingfisher (beach windbreak), hamamelis, palm, rose (rose), balata, balata rubber tree, agaric bamboo ( Agaric, White-faced Agaric, Usukimori no Kasa), Haran, Pariurus (Prunus vulgaris), Parietalia, Harcanlan, Balsamina (Turureishi, Nigauri), Haruni (Chibern, white-skinned, green-leafed), Barbasco, Harlindou, Handaikai ), Breadfruit, halibut (splashing), tiger carrot (participant), pecan nuts, ganbana (stone wall, vine pearl flower), walrus madaharia, higotai, hishi (hishin), pistachio, beet, human head (stone wall), Hitosumidae, Daisies, Daisies Wild boar, cowpea, cypress, cypress, hiba, castor, sunflower, bell pepper, himeuzu (Tianyu), Himematsu (Kaori), Himematsutake (Harimatsutake), Himemuyoran, Pimenta "fruit", beak, cypress "Fruits", chickpeas, Japanese lentils, betel oysters, white-bellied oysters (bald eagle), loquat "fruits, leaves, stems", betel nuts (large clothes skin, coconuts), puer tea (common? Tea), Japanese quail (southern wicker), Japanese cypress, Japanese cypress poppo (Japanese winter flower, Japanese winter lobster), Japanese peach (Orchid), Japanese bean (Japanese peas), Japanese red bean (Chrysanthemum communis, Japanese cypress), Grape "fruit, pericarp, seeds, leaves", beech , Fuyumushinatsutake (Cycium Cordyceps), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant "fruit", Blackberry, Branjen, Plum "fruit", Fruceraria, Blueberry (Prunus japonica), Prunes , Floral blanka, blond psyllium, bundo (mung bean), hazelnut, loofah, hetsukaran, safflower (safflower), heneken, belladonna, berry "fruit", persea, pervianburg, pereschia grandifolia, benzeiso or ixusa (scenic sky), Boy Berries “fruit”, scallop or sardine or nendo or hahagigi kokia (silk), spinach, spinach (saccharus, acute pupa, teleost), pouteria sapota, pouteria lucuma, cypress, spinach, physalis ), Honoki (Japanese Kobak, Pak), Bokeh (Kiso), Hosoba Aburagiku (Painful), Hosobao Guruma, Hosobana Okera (蒼朮), Hosobarakirin (Keiten Sanchi), Hosobabarengiku, Bodaiju (Ogi), Button ( Peony "flowers, leaves, stems, bark"), button pi (peony skin), hops, jojoba, borage (borage), Bordeaux, whittle berries "fruit", hononiku (meat juju, large art), honsekkok (iron skin) Sarcophagus, sparrow mountain spear), Mizurutennansho (Tennansei), Maitake (maiko), maou (mao), maca, Cademia nuts, Margaret (Mokushungiku), Makuri (Marine grass), Magwa (mulberry white bark "bark, leaf"), Magnolia splengeri, Mazaran saba, Masaransuba de Cearer, Masheila de Boy, Mashua (Tamanowen) Halen, Kyukonkinrenka), Matatabi (Midden Tendon), Matsukasa, Pine “Leaf, Bark, Root”, Matta Orillo, Matsutake (Matsutake), Matsuhodo (茯苓), Matico (Cordon Sillo), Mayoram (Hanahakka), Malvano Jazine (Bitter), mulberry "fruit", quince, malein (biloud mud squid), mango, mangosteen, manzanya (andesca mitsule), manshu gurumi, mandarin "fruit", garlic mushroom (reishi), pheasant (fruit "fruit") , Mishima Psycho Or Japanese morning glory (Dragon grass), Mizokakushi (half-sided lotus), Misohagi (Chikuma), Michiyanagi or Niwayanagi (Henshu), Mitsugashi, Mitsuba, Midorisapote, Green mint, Mimosa, Mioga, Miracle fruit "fruit", Myrrh, Mirobaran, Wheat Waragiku, Mukuge (Kiso), Mukunoki, Mukuroji (life extension leather), Munya, Murasaki (purple), Murasakikib or Omurasakikibu (purple pearl), Murasaki corn, Murasaki Kinafuji (Kunming chicken blood wisteria), Megakansa Opuntika, Meshimakobu (Mulberry Yellow), Mehajiki (beneficial mother grass), Mebogi, Japanese evening primrose (Evening primrose), Melaroica, Melissa, Melilot, Melon "fruit", Moukomugi, Mosouchiku, Mokukirin, Moje (Pepper), Mochinoki, Mokkomoji (wood incense) Badaiou, Mo (Peach “leaves, seeds, flowers, fruits”), bean sprouts, morello cherry “fruits”, Morohaya (Hemp), Yakawa Murasakiimo, Yakuchi (Masatoshi), Yakuyo Garega, Yagurumasaku (Yamagagiku), Yam Mahaka, Yacon, Yaba Santa , Yashabushi (Yagari) or Himeyashabushi or Obayayashabushi "fruit, pericarp, fruit ear", pear willow, starfish (octagonal gold plate), mistletoe (willow parasite), willow (kawayanagi, tachiyanagi, weeping willow) , Unryu willow, Miyama willow, palm, willow willow, weeping willow, Tairikuki no willow, fox willow, dronoki), willow tree "leaves, stem", Yaba Santa, Yabgarashi, Yabukouji (purple gold beef), Yab tobacco (crane spider, Tenno Seigo), (Trade land), boletus edulis (porcini, cep, steinpilz), yamanohanki (yamamochi), yamamomo (plum husk), sagebrush, eucalyptus, yukinoshita (tiger ear grass), yucca or flavifolia, yuzu "fruit", lily, yorogusa , Mugwort (carp leaves), ligan (Raimaru), lime "fruit", rye, lacanka "fruit", raspberry "leaves, fruit", latania (chlamelia), rakkyo or shallot (lavender), lavender, longan Agave (Aonu Agave, Fukurin Agave), Ryokucha (Green Tea), Apple "Fruits, Seeds, Leaves, Roots", Gentian, Lubas or Suavisimus (Luo Ryu), Ruritama Thistle (Vulgaria chintai, Xinjiang Lantern), Reishi , Toothpick nucleus), lettuce (chisha), red curl "Fruit", Red Pitaya, Lemon "Fruit", Lemongrass, Forsythia or Syren Forsythia (Regular), Forsythia, Wintersweet, Wacoal, Lokon (Yoshi, Sone), Loganberry "Fruit", Rosemary (Mannenrou) , Rosehip (Novara), Wasabi, Watafujitsugi (Mitsumona), Waremokkou (earthen) and the like.
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As seaweeds, seaweed [Green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usba aonori, Sugiaonori, Hiraaoori, Boaonori, Hosoeda Aonori), Anaaosa (Aosa)] (Macombu, Resilibu, Hosocome, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis Integrifolia, Macrosistis Integrifolia, Neocites Ruetkeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchichiwa Umiuchiwa, Akaba Umiuchiwa, Konami Uchiwa, Okinawa Uchiwa, Usuki Uchiwa, Etsumi Uchiwa], seaweed [Red Algae: Hijirimen, Maca (Tengusa), Hiluxa, Syria, Occasus , Kata-bucka, Yatabegusa, Yuukiri, Shimatengusa, Tosakanori, Togekirinsai, Amakusakirinsai, Giraffe, Juniper-Kinkisai, Tsunomata, Otsutsunomata, Tocha-ka-no-no-Tama, Togetu-no-Tata Typical examples include Kainori, Yaleus banori, Kagios banori, Susius banori, Haius banori, Akamominori.
[0044]
In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kuwanomimo: Kuwanomimo, Volbox: Ohigegawa, Volbox, Palmera, Yotsumeo, Aomido: Chrysanthemum, Aoumidro, Tirgimidro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa Magama genus: Magamata, Iwagata: Fusaikawa, Surichogata, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibutimil, Nagamil, Hira Lemon, Casanori genus: Casanori, Jusmo genus: Jujusmo, Tamajusmo, Mizojuzumo, Mika ヅ kimo, Korekaete, Tsutsumimo genus: Kyukougusa, Homogusa genus: Human esca Sumiremo: Sumiremo, Hoshimamidro, Fushinashimidoro etc.).
[0045]
Cyanobacteria (Suizenjinori: Suizinori, Aoko, Nenju: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Aiacacio), etc.).
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Brown alga Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigamushisa: Jigmygusa, Umichiwagusa, Umamisakugura, Hiramusa : Navarimo, Chasomen genus: Motsuki Chasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawa mozuku: Okinawa mozuku, fake Tomozuku: Niseft Mozuku, Futomozuku: Futomozuku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozuku, Mozuku: Mozuku, Ishige: Ishige, Iroro, Ichimosa: Ichimegasa Umibosu, Urushigusu: Urushigusa, Keurushigusa, Tobacco gussa, Compositae: Compositinum, Habasmodoki: Haberodoki, Habanori: Habanori, Habanori: Common Haburori, Commonbukuro, Ezobukuro, Ezobukuro Chishima fukuronori genus: Chishima fukuronori, Kagomenori genus: Kagomenori, Muraridori genus: Murachidori, shark genus: shark zusa, genus genus: lobster, genus genus: yokojimamanori, Ganoderma genus: cynomolgus, fennel spider: fennel spider, genus cirrus: turmo, turtle genus: shark, genus genus: sujime, misjikonbu genus: misjikonbu, atsuba misjikonbu, konbu genus: tsutsugarakonbu, kakijima konbu, onikombu, gakonbubu Barracuda, Trolocomb, Anthrome, Antokume, Antarctic, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikombu, Kikuishikonbu, Nejirumubu: Nejirebubu, Kuroshiome: Kuroshiome, Nekoshikonbu, Aramei Genus: Ainuwakame, Chigaiso, Oniwakame Ezoi Shige: Ezoi Shige, Yabane Moku: Yabane Moku, Rappa Moku: Rappa Moku, Joromoku: Ugano Moku, Jo Lomoku, Hiemoku, Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumata Moku, Umitranoo, Obamoku, Fushishimoku, Hahamokumoku , Ukimo: Ouokimo, Burukimo: Burukimo, Kayamonori: Kayamonori, etc.).
[0047]
Red algae Genus: Sea urchin, Tsukumonori, Anemone crispula, Astragalus serrata Genus: Tamaitadaki, Kaikekenori Genus: Kaginori, Kaikekenori, Tengusa: Himetengususa, Hytengususa, Oobusa, Nambugu , Kohira, Yohira, Kinukusa, Hibiro, Genus: Hibirodo, Himebiro, Isommedo: Isommedo, Aedes: Rhizome, Ryumons: Ryumon, Ranunculaceae Naminohana: Hosobanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwakawa, Kainokawa Kyono Shiro, Sakuranori, Nikumukade, Tambanori, Tsurutsuru, Fudarak, Marubahdarak, Isonohana: Nurakusa, Ronulaksa, Oomkadenori, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Rice, Tokamatsu, Hitomatsu, Fusikintoki, Tsunomude, Nagakintoki, Toss Nagaobane: Naganobane, Funori genus: Hanafnori, Fukurofunori, Mafunori, Karekigusa: Karekigusa, Tosakamodoki: Hosobatanosakamodoki, Hirohatosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodokiza, Zotosodomo Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Tacarimenia, Hoonoo: Houno, Hikagenoit: Hikagenoit, Usuginu, Nikuhounoo: Nikuhounoo, Venus nago, Venetian nago, Suskakebeni: Susukabeni, Okaramusa: Yamadagusa, Mirin: Mirin, Hosokamizoe, Ezochosto , Isomocca genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagibaranori, Kizinomo: Kizinoo, Isodantsu: Isodantsu, Atsubanori: Atsubanori, Ogonori, Ogonori Mizo-okonori, birch, beniogonori, fukureshinori, purple birch, shinkaibanori, spruce birch, kataogonori, ryukyuogono Li, Atlantic scorpion, Japanese cypress, Nymphalus Itagususa, Saimi, Spirella, Lotus Jigusa: Lotus Jigusa, Sugi nori: Ikanoashi, Hosobonori, Nobonori, Black Haginansou: Black Haginansou Genus: gourd, cherries, octopus: octopus, sedge, genus: genus, genus: goat, dals : Dulse, Scorpiona, Anadalus, Weibusa spp. , Egonori: Egonori, Futogigi, Saeda: Saeda, Chirimomidae: Chilemomiji, Shiranogi Family: Habutaenori, Konohanori, Suzuronori, Usbeni genus: Genus: Kagios banori, Yareus banori, Susius banori, Heius banori, Usubanorimodoki: Usubanorimodoki, Ayanishiki genus: Ayani Genus: Aeginu, Dadia: Enasidadia, Shimadadia: Isohagi, Shimadadia, Dajimodoki: Dajimodoki, Euglena: Mourotogususa, Fuyugusa, Makuri: Makri, Yanaginogi, Yuna, Yukinagina , Sasabayanaginori, Sozo genus: Kurosozo, Kobsozo, Hanesozo, Sozonohana, Hanegusa genus: Hananegusa, Hananegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosozozanemo, Himegoshigusu, Hoshidokugu Isomagusa, Suginasugusa: Suginasusa, Isobashou: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed: Haeshinosakiba, Kawamoku : Kawamoku, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome: Ideyugogome, Okichimozuku: Okimozu, Otosa, Chinomo: Chinomo, Chisujinori, Chisujinori, etc.).
[0048]
Axial algae (Shajikumo, Shiratamamo, Hoshitsurimo: Hoshitsurimo, Rikunotumusu, Flaskmo: Himebumo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo, etc.), etc.
[0049]
In addition, the materials derived from animal materials include chicken crown extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposition product thereof, cow or pig brain tissue Extracts, cattle / pigs / fish collagen hydrolyzate (acid, alkali, enzyme etc.) degradation products, water-soluble collagen or collagen derivatives such as acylated collagen, cattle / pigs / fish elastin or elastin hydrolyzate (acid, Alkaline, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or cow blood cell protein degradation product (globin peptide), cow or pig hemoglobin Degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its degradation products or derivatives thereof, skim milk powder and its degradation products or it Derivatives, lactoferrin or decomposed product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.
[0050]
In addition, as a material derived from a plant or animal material, any site, cell, tissue, organ, metabolite, etc. derived from a gene recombinant or a cell fusion can be used. Furthermore, for example, an undifferentiated cell group, a cell group in the middle of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can also be used.
[0051]
(14) Marine components
Seawater such as deep seawater, for example, sea salt, dried seawater, dead sea or Atlantic or Pacific sea water (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango), for example Sea mud or mud from various locations such as Italy, Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, black meteorite, etc.
[0052]
(15) Microbial culture metabolites
Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermented extract, rice bran (red rice cake, birch ) Fermented extract, Euglena extract or decomposition product thereof or water-soluble derivative thereof, trehalose or derivative thereof, lactic acid fermentation product of raw milk or skim milk powder, lactic acid bacteria fermentation product of legumes, lactic acid bacteria fermentation product of coconut genus plant, etc.
[0053]
(16) α-hydroxy acids
Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.
[0054]
(17) Inorganic pigment
Silica, magnesium silicate, talc, kaolin, bentonite, mica, mica titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.
[0055]
(18) UV absorption / blocking agent
Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sulfone Acid sodium, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.) , Methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, paramethoxycinnamon 2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl mono-2-ethylcinnamate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, Myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives , Dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives , Vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, thorisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, Talc, kaolin, etc.
[0056]
(19) Whitening agent
Paraaminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives Nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein , Berberine, placenta extract, ellagic acid, lucinol etc.
[0057]
(20) Tyrosinase activity inhibitor
Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E or a derivative thereof, N-acetyltyrosine or a derivative thereof , Glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camille, mulberry, gardenia, touki, firewood, clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhod, Pearl barley, nettle, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankei, hamamelis, carraguwa or yamagwa, life-grass, bellflower, toshishi, sequel, shooting dry, mao, senkyu, dokatsu, psycho, Ufuu, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.
[0058]
(21) Melanin pigment reduction / degradation substance
Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivatives (hydroquinone benzyl ether).
[0059]
(22) Turnover promoting action / cell activator
Hydroquinone, Lactic acid bacteria extract, Placenta extract, Ganoderma extract, Vitamin A, Vitamin E, Allantoin, Spleen extract, Thymus extract, Yeast extract, Fermented milk extract, Plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock, Shikon, Carrot, Hamamelis, Hop, Yokuinin, Odori Sou, Assembly, Toki, Toki Senko, Achacha, Hypericum, Cucumber, Ginger, Mannenrou, Parsley).
[0060]
(23) Astringent
Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds), etc.
[0061]
(24) Active oxygen scavenger
SOD, catalase, glutathione peroxidase and the like.
[0062]
(25) Antioxidants
Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol , Sesamorin, gossypol, propolis, etc.
[0063]
(26) Lipid peroxide production inhibitor
β-carotene, plant extract (sesame cultured cells, amacha, hypericum, clams, clove, melissa, enamel, birch, salvia, mannenrou, nanzenji, ages, ginkgo, green tea).
[0064]
(27) Anti-inflammatory agent
Itamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof Salt, licorice extract, sicon extract, age extract, propolis, etc.
[0065]
(28) Antibacterial / disinfectant / disinfectant
Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salicy powder, iodine compound, iodoform, sorbin Acid or salt thereof, propionic acid or salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m -Xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidi , Ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether) , Polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzaza chloride) (Luconium, Benzethonium chloride, Methylrosaniline chloride), Formaldehyde, Hexamine, Brilliant green, Malachite green Star Le violet, Jamaru photosensitive No. 101-containing, photosensitizer No. 201, photosensitizer No. 401, N- long chain acyl basic amino acid derivative and its acid shark salts, zinc oxide, hinokitiol, Sophora root, propolis, and the like.
[0066]
(29) Moisturizer
Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprycapric acid, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative Pyrrolidonecarboxylic acid or a salt thereof, sodium lactate, urea, sorbitol, amino acid or derivative thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, Tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and their sulfates, Acid salt, nitrate salt, citrate salt or pyrrolidone carboxylic acid), oils and fats “Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, Cucumber oil, beef tallow fatty acid, quince seed oil, cucumber nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, Peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, molasses, coconut oil, eucalyptus oil, beef tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (hardened) Oil), waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanoli , Hard lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), natto bacteria metabolite, natto extract, silk fiber extract, plant extract (Akamatsu sap, aloe, kudzu, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or birch sap, assembly, mulberry white skin, birch leaf, loofah, peony skin, persimmon) and the like.
[0067]
(30) Elastase activity inhibitor
Fluorophosphate diisopropyl, plant extract (Ogon, Hypericum, Clara, Mulberry leaves, Keihi, Gennosho, Comfrey, Salvia, Elderberry, Bodaige, Buttonpi), seaweed extract, etc.
[0068]
(31) Hair preparation
Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, red pepper tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, thioglycolic acid and the like.
[0069]
(32) Antiandrogen
Follicular hormone (estrone, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.
[0070]
(33) Peripheral blood flow promoter
Vitamin E or its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.
[0071]
(34) Stimulant
Pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.
[0072]
(35) Metabolic active agent
Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.
[0073]
(36) Antiseborrheic agent
Pyridoxine or its derivatives, sulfur, vitamin B6 and the like.
[0074]
(37) Keratolytic agent
Resorcin, salicylic acid, lactic acid, urea, etc.
[0075]
(38) Oxidizing agent
Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate Sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.
[0076]
(39) Hair remover
Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) etc.
[0077]
(40) Hair swelling agent
Ethanolamine, urea, guanidine, etc.
[0078]
(41) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol Paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- ( 2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorcresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, sulfuric acid Orthochloroparaphenylenediamine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitrosulfate sulfate Triphenylenediamine, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcinol Tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.
[0079]
(42) Fragrance
Natural animal fragrances such as musk, civet, castrium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, dairy perfume essential oil, Tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, troubalsum essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, pel Vegetable flavors such as balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannenrou) essential oil, Japanese mint mint essential oil, etc. Synthetic fragrance etc.
[0080]
(43) Dyes / colorants
Red cabbage dye, red rice dye, red dye, anato dye, squid dye, turmeric dye, enju dye, krill dye, amber dye, caramel, gold, silver, gardenia dye, corn dye, onion dye, tamarind dye, spirulina dye, Buckwheat whole pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin etc.
[0081]
(44) Sweetener
Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract, etc.
[0082]
(45) Nutrition enhancer
Shell-calcined calcium, cyanocolabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron, etc.
[0083]
(46) Dairy products
Milk, cheese, fresh cream, butter, margarine, powdered milk, whey, condensed milk, etc.
[0084]
(44) Other
Hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animal and plant polysaccharides and their degradation products , Animal / vegetable glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound treatment agents, foam enhancers, thickeners, enzymes, purified water (electronic water, small clusters) ), Oral preparations, deodorants / deodorants, bitterings, seasonings, etc., and the combined use with these is expected to improve the effects of the present invention or other cosmetic effects. it can.
[0085]
【Example】
Hereinafter, the present invention will be described in more detail by showing production examples, test examples, and formulation examples. However, the present invention is not limited to these.
[0086]
[Production Example 1]
About 100 kg of the above-ground portion of dried Japanese black sprouts is heated and extracted with 10 times the amount of purified water (about 80 ° C.) for about 5 hours and filtered to obtain about 1.0 kg of the extract (dry solid content: about 1.0%). Obtained.
[0087]
[Production Example 2]
Immerse 100 g of the dried plant of the Japanese black-and-white plant in a 10-fold amount of 30% ethanol solution, extract it at room temperature for 5 days and nights, and filter to extract about 1.0 kg of the extract (dry solid content: about 1.4%). Obtained.
[0088]
[Production Example 3]
100 g of the above ground portion of dried himefuuro is immersed in 10 times the amount of 30% 1,3-butylene glycol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain an extract (dry solid content: about 1.2%) About 1.0 kg of was obtained.
[0089]
[Production Example 4]
Transfer 100g of dried Japanese black sprouts to an extraction container and extract pressure 150kg / cm ² , Separation pressure 40 kg / cm ² Then, supercritical extraction was performed by supplying carbon dioxide in a supercritical state at a temperature of 45 ° C. to obtain 0.92 g of a supercritical extract.
[0090]
[Test 1] Tyrosinase activity inhibitory action test
"Method"
A tyrosine solution (L-tyrosine 0.3 mg / mL) 1.0 mL, a mucklevine buffer solution (pH 6.5) 2.0 mL, and a sample solution 0.2 mL were mixed, and the mixture was maintained in a 37 ° C. constant temperature bath for about 10 minutes. After standing, 0.1 mL of tyrosinase solution (derived from mushrooms, 2500 unit / mL) was added thereto, and then the absorbance at 475 nm was measured (A), and then the reaction solution was left in a 37 ° C. constant temperature bath for 20 minutes. Thereafter, the absorbance at 475 nm is measured in the same manner (A ′). At the same time, as a blank, instead of the sample solution, the absorbance was measured with purified water in the same manner (a) and (a ′), and the tyrosinase activity inhibition rate was determined by Equation 1. FIG. 1 shows the result.
"sample"
As the sample solution, the products of the present invention obtained in Production Examples 1 to 3 were adjusted with purified water so as to have a solid content concentration of 0.1%, and were subjected to the test.
[0091]
<Equation 1>
Tyrosinase activity inhibition rate (%) = {(a′−a) − (A′−A)} / (a′−a) × 100
[0092]
"result"
From FIG. 1, it was confirmed that the product of the present invention has a tyrosinase activity inhibitory action and is useful as a whitening agent.
[0093]
[Test 2] Melanin production test
The present inventor decided to evaluate the melanin producing action based on B16 melanoma cells.
"Method"
B16 melanoma cells pre-cultured for 24 hours are transferred to a fresh medium, to which 0.5% of a sample is added and cultured for 3 days. Next, the cultured cells are treated with trypsin, heated and dissolved in 1N-NaOH, 10% DMSO solution, and the absorbance at 420 nm is measured. In addition, distilled water was used as a blank instead of the sample, and the activity of the cells to which the sample was simultaneously added was measured by the MTT reduction method (Tim Mosmann; Journal of Immunological Methods p55-63 (1983) reference). The MTT reduction activity of the sample-loaded cells was calculated with the MTT reduction activity of the cells as 1 unit. The results are shown in FIG.
"sample"
The sample was subjected to the test using the extract obtained in Production Example 1 of the present invention (solid content concentration: adjusted to 0.5%). A 30% ethanol solution was prepared as a blank sample, and arbutin (0.5%) was prepared as a comparative sample under the same conditions and used in the test.
[0094]
"result"
As shown in FIG. 2, the Japanese black extract of the present invention produced less melanin than arbutin, as well as a blank 30% ethanol solution. Therefore, it was confirmed that it has a strong melanin production inhibitory effect. Therefore, it can be effectively used as a whitening agent.
[0095]
[Test 3] Lipid peroxide production inhibitory action
"sample"
A dried product of the extract of the yellow spider obtained in Extraction Example 1 was dissolved in purified water so as to have a solid content concentration of 0.1%, and tested. As a comparative sample, tocopherol (0.1%) was prepared under the same conditions and used for the test.
[0096]
"Method"
0.1 mL of a test sample is added to 4.9 mL of a solution obtained by dissolving 0.1% linolenic acid in 0.8% sodium lauryl sulfate, and ultraviolet rays are irradiated for 1 hour. Take 1.0 mL of this reaction solution in a centrifuge tube containing 4.5% dibutylhydroxytoluene as a reaction terminator, add 1.0 mL of thiobarbituric acid solution, and heat at 95 ° C. for 1 hour. After cooling, 4.0 mL of butanol solution was added, shaken well, and then centrifuged, and the absorbance of the butanol layer at 532 nm was measured. In addition, the thing which added the solvent instead of the sample was used as a control, and a blank which was not irradiated with ultraviolet rays was set for each sample and control, and the lipid peroxide production inhibition rate (%) was determined by Equation 2. The result was as shown in FIG.
[0097]
<Equation 2>
Lipid peroxide production inhibition rate (%) = {1− (sample OD value−blank (sample) OD value) / (control OD value−blank (control) OD value) } × 100
[0098]
"result"
As shown in FIG. 3, the superior extract of lipid peroxidation was recognized in the extract of Japanese black spider of the present invention, and it was recognized that it was useful as a lipid peroxide production inhibitor.
[0099]
[Test 4] Collagenase (MMP-1) production test
"sample"
A dried product of the extract of the yellow spider obtained in Extraction Example 1 was dissolved and adjusted in a 30% ethanol solution so as to have a solid content concentration of 1000 ppm, and was tested. Further, as a blank sample, a 30% ethanol solution was prepared under the same conditions and used for the test.
[0100]
"Method"
The culture supernatant of fibroblasts cultured with 5% FBS-DMEM was removed, and the cells were washed twice with 25 mM HEPES buffer. Add Trypsine-EDTA solution, 37 ° C, 5% CO ₂ And left for 10 minutes. After 10% FBS-25 mM HEPES buffer was added to stop the reaction, the cell was collected by centrifugation at 1000 rpm for 5 minutes. 6x10 each in 24 well plates for cell culture (Corning 3526) ⁴ cell / well seeded, 1% 5% FBS-DMEM at 37 ° C., 5% CO ₂ Cultured under conditions. After 24 hours, the medium was changed to 0.02% LAH-DMEM containing IL-1α, and 10 μL of a sample was added. 37 ° C, 5% CO ₂ After culturing under conditions for 48 hours, the culture supernatant was centrifuged at 10,000 rpm for 10 minutes, and the amount of MMP-1 in the supernatant was determined using Matrix Metalloproteinase-1 (MMP-1), Human, ELISA System (Amersham Pharmacia Biotech UK Limited, RPN2610). ) And measured.
The amount of MMP-1 produced was calculated by preparing a calibration curve from any MMP-1 concentration at the same time during ELISA. The result was as shown in FIG.
[0101]
"result"
As shown in FIG. 4, the extract of Japanese black spider of the present invention was found to have an effect of significantly suppressing MMP-1 production and was useful as a collagen degradation inhibitor.
[0102]
[Test 5] Hyaluronidase activity inhibitory action
"sample"
The dried product of the extract of the yellow spider obtained in Extraction Examples 1 to 3 was dissolved and adjusted in purified water so as to have a solid content concentration of 0.5%, and was tested.
[0103]
"Method"
Add 0.1 mL of the hyaluronidase solution (final concentration: 0.4 mg / mL) to 0.1 mL of the sample, leave it at 37 ° C. for 20 minutes, add the Compound 48/80 solution (final concentration: 0.1 mg / mL), and then add 37 After standing at 20 ° C. for 20 minutes, 0.25 mL of a hyaluronic acid solution (final concentration 0.4 mg / mL) was added, and the mixture was allowed to stand at 37 ° C. for 40 minutes. Next, after 0.1 mL of 0.4N sodium hydroxide solution was added to stop the reaction, 0.1 mL of 0.8 M potassium borate solution was added and heated in boiling water for 3 minutes. After cooling to room temperature, 3 mL of 1% p-dimethylaminobenzaldehyde acetic acid solution was added, and the mixture was allowed to stand at 37 ° C. for 20 minutes, and then the absorbance at 585 nm was measured. In addition, as a control, a blind test in which the enzyme was replaced with purified water was used as a solvent for the sample, and the hyaluronidase activity inhibition rate was determined from the following formula (Equation 3) from the difference in absorbance between the test sample and the test sample. The result was as shown in FIG.
[0104]
<Equation 3>
Hyaluronidase activity inhibition rate (%) = 100 − {(sample specimen absorbance−sample blind absorbance) / (control specimen absorbance−control blind absorbance)} × 100
[0105]
"result"
As shown in FIG. 5, the extract of Himefuuro of the present invention was found to be effective as a hyaluronidase inhibitor because of its significant inhibitory effect on hyaluronidase activity.
[0106]
[Test 6] Inhibition of histamine release
In an immediate allergic reaction, chemical mediators such as histamine are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic action. In this test, a test method (J. Soc. Cosmet. Japan, Vol. 25, No. 4, P246 (1992)) for releasing histamine from rat mast cells with compound 48/80, which is a histamine release reagent, was used. The extract obtained in (1) was examined.
[0107]
"sample"
A dried product of the extract of Japanese yellow sprouts obtained in Extraction Examples 1 and 2 was dissolved in purified water so as to have a solid content concentration of 0.01%, and then tested.
[0108]
"Method"
In a 1.2 mL mast cell suspension collected from the abdominal cavity of a rat (Slc: Wistar male rat, about 4-9 weeks old), 0.2 mL of the sample and compound 48/80 are adjusted to a final concentration of 1.0 μg / mL. And incubated at 37 ° C. for 15 minutes. After stopping the reaction by cooling with ice, the reaction solution is centrifuged, and histamine released from the supernatant is extracted and purified, colored with o-phthaldialdehyde, and the fluorescence absorbance at an excitation wavelength of 360 nm and a fluorescence wavelength of 450 nm is measured. The histamine release inhibition rate was determined by the following formula <Equation 4>. The result was as shown in FIG.
[0109]
<Equation 4>
Histamine release inhibition rate (%) = {1− (A−C) / (B−C)} × 100
A: Fluorescence intensity of histamine released when a sample was coexisted with mast cells and a histamine releasing agent was added.
B: Fluorescence intensity of histamine released when histamine releaser was added to mast cells
C: Fluorescence intensity of histamine naturally released from mast cells
(A, B, and C are the measured values minus the blind values.)
[0110]
"result"
As shown in FIG. 6, the extract of Himefuuro of the present invention was confirmed to have a histamine release inhibitory action, and was found to be useful as a histamine release inhibitor and an anti-inflammatory agent.
[0111]
[Test 7] Safety test
(1) Skin primary irritation test
Hartley guinea pigs (female, 3 per group, body weight) prepared by preparing an aqueous solution so that the solid content concentration was about 1.0%, and extracting the extract of Japanese black spider obtained in Extraction Examples 1 to 4 Skin around 2 × 2cm) ² A 0.03 mL was applied to each animal. Judgment was performed 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indices. As a result, in all animals, no erythema and edema were observed, and it was judged negative.
[0112]
(2) Cumulative skin irritation test
An aqueous solution was prepared so that the solid content concentration was about 2.0%, and the flank was shaved (2 × 2 cm). ² ) Hartley guinea pig skin (female, 3 animals per group, weight around 320 g) 2 × 2 cm ² Per animal, 0.03 mL was applied to each animal once a day, 5 times a week. Application was performed over 2 weeks, and shaving was performed in a timely manner. Judgment was made on the day of each application and the day after the last application by the scoring method of primary irritation using erythema and edema as indices. As a result, in all the animals, no erythema and edema were observed for 2 weeks after application, and the animals were judged negative.
[0113]
(3) Single dose toxicity study
An aqueous solution was prepared so that the solids concentration was about 1.0% from the extract of the yellow spider obtained in Extraction Examples 1 to 4, and 16 ml / kg of each was fasted for 16 hours before the test. Systemic mice (male and female, 1 group, 5 animals, 5 weeks of age) were orally administered with a sonde, and the onset, degree, etc. of toxic symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and no abnormalities were found in the anatomy. Therefore, LD ₅₀ Was 2,000 mg / kg or more, and judged to be a safe substance.
[0114]
EXAMPLES Production of various cosmetic compositions
Various cosmetic compositions according to the present invention were prepared. The prescription example is shown below.
[0115]

[0116]

[0117]

[0118]

[0119]

[0120]

[0121]

[0122]

[0123]

[0124]

[0125]

[0126]

[0127]

[0128]

[0129]

[0130]

[0131]

[0132]

[0133]

[0134]

[0135]

[0136]

[0137]

[0138]
[Test 8] Use test 1
The use test of the cosmetic composition of the above example was conducted. In other words, panelists for stains and freckles, people who suffer from darkness (10 people), people with atopic dermatitis who suffer from eczema, etc. (6 people), rough skin (4 people), and people who suffer from wrinkles and sagging skin (11 people) Each day, twice a day in the morning and at night, after applying a face wash, an appropriate amount of the emulsion of Prescription Example 1 (Emulsion 1) was applied to the face for 1 month. As a control product (milky lotion 2), a formula prepared in the same manner by replacing the milky extract of the present invention with purified water from the milky lotion was used. In addition, without notifying the panelist of the contents of the emulsion, two points were determined, and the emulsion 1 and the emulsion 2 were applied without fail, respectively, and subjected to comparative evaluation. The results are shown in Table 1. The numbers in the table represent the number of people who answered that they were valid.
[0139]
[Table 1]

[0140]
[Test 9] Use test 2
The use test of the granule bath preparation A of the above Example was conducted. In other words, a panel was composed of people with no skin tension (6 people) and people who feel itchiness and itching on the back after bathing (15 people), and they tried bathing with bathing agents every day for one month and asked for a questionnaire. The results are as shown in Table 2, and the numbers in the table represent the number of people.
[0141]
[Table 2]

[0142]
As shown in Tables 1 and 2, each cosmetic composition containing the extract of the present invention is a whitening effect such as blemishes, freckles, and improvement of skin darkness, skin aging prevention such as improvement of rough skin, wrinkles, firmness, and sagging skin, and It has been confirmed that it has extremely remarkable effects on anti-inflammatory and anti-allergic effects such as improvement of atopic dermatitis such as eczema and prevention / improvement of Kayumi.
[0143]
【The invention's effect】
The extract of himefuuro according to the present invention is a material having a multifunctional cosmetic action such as melanin production inhibitory action, lipid peroxide production inhibitory action, collagenase production inhibitory action, hyaluronidase inhibitory action, histamine release inhibitory action, and safe and Excellent stability. Applying this, the whitening agent, antioxidant, skin aging prevention / improving agent, anti-inflammatory agent, and cosmetic composition of the present invention are spots, freckles, darkness improvement, eczema, rough skin, wrinkles, firmness and skin. It has extremely remarkable effects on anti-inflammatory and anti-allergic effects such as prevention of skin aging such as improvement of sagging, improvement of atopic dermatitis, prevention and improvement of Kayumi.
[Brief description of the drawings]
BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a graph showing the tyrosinase activity inhibitory action of the extract of the urine of the present invention.
FIG. 2 is a diagram showing the amount of melanin produced by the extract of the Japanese black spider of the present invention.
FIG. 3 is a diagram showing the lipid peroxide production-inhibiting action of the Japanese black-and-white extract of the present invention.
FIG. 4 is a graph showing the amount of collagenase (MMP-1) produced by the extract of Japanese black spider of the present invention.
FIG. 5 is a diagram showing the hyaluronidase activity inhibitory action of the extract of Japanese yellow turf of the present invention.
FIG. 6 is a graph showing the histamine release-inhibiting action of the extract of the urine of the present invention.

Claims (5)

Whitening agent characterized by containing Himefuuro extract. Antioxidant characterized by containing Himefuuro extract. A skin aging preventive / improving agent characterized by containing a Himefuuro extract. An anti-inflammatory agent characterized by containing a himefuuro extract. A cosmetic composition comprising a himefuuro extract.

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