CN107569421A - A kind of soluble nti-freckle micropin - Google Patents
A kind of soluble nti-freckle micropin Download PDFInfo
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Abstract
The invention discloses a kind of soluble nti-freckle micropin, including active ingredient, in parts by weight, the active ingredient includes：Tranexamic acid, urea, citric acid, soluble collagen, xanthans, Argireline 2, nonapeptide 1, Scutellaria galerioulata L extract, Ou Jing certain herbaceous plants with big flowers extracts, peppery mint extract, cowslip extract, garment or robe made of feathers leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil extract.Soluble nti-freckle micropin provided by the invention has advantages below：By selecting the height of various medicine for removing speckle and carrying out best of breed, so as to reduce the dosage of every kind of medicine and toxic side effect, expand its safe range and use range；The metabolism of skin can be improved, improve the microenvironment around skin, fundamentally nti-freckle, no longer recurs, and is readily produced, transports and stores, and reduces cost.
Description
Technical field
The invention belongs to cosmetic technical field, and in particular to a kind of soluble nti-freckle micropin.
Background technology
Color spot, refer to the spot different with ambient color.Including freckle, blackspot, chloasma and senile plaque expelling etc., category pigment barrier
Impenetrability skin disease.A kind of common face formed due to the increase of dermal melanin is brown or melanin pigmentation, damage are held
The disease of skin of property, is mainly in cheek and forehead position, women is more common in Exposure to Sunlight postemphasis, is had with pregnant, long-term paramenia
Close.The treatment of color spot is extremely difficult, and prevention and controls common at present include common prevention measure and drug therapy.Drug therapy is again
Including systemic drug treatment and topical medications.Specifically there are following several ways.
1st, common prevention measure
(1) Exposure to Sunlight is avoided：Due to having confirmed that ultraviolet irradiation can cause melanin to increase, so avoiding Exposure to Sunlight from keeping away
Exempt from the exacerbation of chloasma, ensure the therapeutic effect of chloasma.When movable out of doors, it is necessary to use sunshade tool or suncream.
(2) reducing stimulates：The stimulation to skin of face, the especially rubbing energetically to color spot position are reduced as far as possible, are washed one's face
Shi Bixu is soft, reduces the massage to face and nurses.Many color spot patients often carry out cosmetic repeatedly and unloaded to lesion region
Adornment, it is a kind of stimulation to color spot, causes the further deterioration of color spot.
(3) cosmetics are reduced：The use of cosmetics is reduced as far as possible, it is especially desirable to is avoided using savory and excitatory
Cosmetics.
(4) contraceptive is disabled：Some patients color spot after contraceptive is disabled can mitigate.
2nd, systemic drug is treated
(1) vitamin c：Vitamin c can suppress the formation of melanin, often as ancillary drug application.In order to promote
Hypopigmentation, vitamin C can be used, is preferably injected intravenously.
(2) plant extracts：Such as Asiaticoside, greenweed extract, husky fir extract, liquiritin, rhizome of chuanxiong piperazine etc., have
Suppress the effect that melanin is formed.
(3) traditional Chinese medicine：The traditional Chinese medical science is typically soothing the liver by kidney tonifying using prescription such as Taohong Siwu Tang etc., and the regulation of qi and blood reaches
The effect of resolving sputum ecchymose removing, is treated to color spot.
3rd, topical medications
Various decolorising agents, most commonly hydroquinones (quinhydrones), it is always the preferred local application for treating chloasma, but
Concentration is difficult to grasp, and easily the Secondary cases pigmentation after generation medication, especially yellow easily occur this concurrent
Disease.Other topical medications are more unstable to Asian curative effect, easily produce dermatitis, atrophoderma, color spot exacerbation etc.
Adverse consequences.
The equal therapeutic effect unobvious of various nti-freckle methods above, healing time length, recurrence rate are higher.Up to now, also
There is no a kind of method or medicine that can fundamentally remove color spot.
In addition, nti-freckle product on the market is transported, stored in fluid form mostly at present, liquid storage time is short, no
Beneficial to transport, easily go mouldy or aoxidize.
The content of the invention
The present invention provides a kind of soluble nti-freckle micropin for defect present in prior art, and the micropin can be effective
Nti-freckle, utilization rate of active components is high, has no toxic side effect, easy to use, quick.
The purpose of the present invention is achieved through the following technical solutions：
A kind of soluble nti-freckle micropin, including active ingredient, in parts by weight, the active ingredient includes：
Tranexamic acid 1.5-32 parts, urea 3-10 parts, citric acid 0.2-1.5 parts, soluble collagen 10-33 parts, xanthans 15-
40 parts, the 16-67 parts of Argireline -2, the 8-56 parts of nonapeptide -1, Scutellaria galerioulata L extract 2-14 parts, Ou Jing certain herbaceous plants with big flowers extract 5-18 parts,
Peppery mint extract 7-30 parts, cowslip extract 16-43 parts, garment or robe made of feathers leaf extract 0.5-5 parts, veronica officinalis carry
Take thing 0.5-5 parts, sweet mary leaf extract 15-36 parts, common milfoil extract 13-53 parts.
Further, in parts by weight, the active ingredient includes：Tranexamic acid 5-26 parts, urea 5-8 parts, citric acid
0.5-1.3 parts, soluble collagen 14-26 parts, xanthans 19-27 parts, the 24-53 parts of Argireline -2, the 17-33 parts of nonapeptide -1, helmet
Shape Baical Skullcap root P.E 5-13 parts, Ou Jing certain herbaceous plants with big flowers extract 8-14 parts, peppery mint extract 13-24 parts, cowslip extract 23-
37 parts, garment or robe made of feathers leaf extract 0.5-3 parts, veronica officinalis extract 1-4 parts, sweet mary leaf extract 22-30 parts, common milfoil
Extract 19-47 parts.
Further, in parts by weight, the active ingredient includes：16 parts of tranexamic acid, 5 parts of urea, 1 part of citric acid,
20 parts of soluble collagen, 23 parts of xanthans, 35 parts of Argireline -2,27 parts of nonapeptide -1,9 parts of Scutellaria galerioulata L extract, Ou Jingkui
12 parts of extract, peppery 18 parts of mint extract, 32 parts of cowslip extract, 1.8 parts of garment or robe made of feathers leaf extract, medicinal grandmother
Receive 2 parts of extract, 26 parts of sweet mary leaf extract, 29 parts of common milfoil extract.
In addition to Duyun Maojian Tea extract 8-22 parts further, in parts by weight,.
Further, in addition to decoyl salicylic acid 7-30 parts, sodium hydroxide 0.2-1.8 parts, mandelic acid 50-75 parts, 1,2-
Hexylene glycol 3-8 parts, pungent glycol 1-3 parts.
Further, in addition to surrounding layer, the material for forming surrounding layer is selected from vinyl pyrrolidone and its derivative
Monomer-polymer or copolymer, ethyl cellulose, hyaluronic acid, glucan, soluplus (Polyvinylcaprolactames-poly- acetic acid
Vinyl acetate-polyethyleneglycol-graft copolymer), hydroxypropyl methylcellulose, methacrylic acid copolymer, the copolymerization of quaternary amine methacrylic acid
Thing, PLA, polyglycolic acid, peptides chondroitin, collagen, chitosan, amylopectin, one kind in polysaccharide polymer or more
Kind.
Further, the material for forming surrounding layer is hyaluronic acid, the mass concentration of the hyaluronic acid for 15%~
20%.Exemplary, the mass concentration of hyaluronic acid is 18%.
The invention also discloses the preparation method of soluble nti-freckle micropin, comprise the following steps：
S1：Prepare Scutellaria galerioulata L extract, Ou Jing certain herbaceous plants with big flowers extracts, peppery mint extract, cowslip extract, the garment or robe made of feathers
Leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil extract and Duyun Maojian Tea extract, it is standby
With；
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Ou Jing certain herbaceous plants with big flowers extracts, peppery peppermint are weighed respectively
Extract, cowslip extract, garment or robe made of feathers leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil
Extract and Duyun Maojian Tea extract, deionized water 300-400 parts are added, is mixed evenly, filters to take filtrate；
S3：According to parts by weight weigh tranexamic acid, urea, citric acid, soluble collagen, xanthans, Argireline -2, nonapeptide -
1st, decoyl salicylic acid, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, the filtrate described in step S2 is added it to
In, it is well mixed, low temperature (less than 40 DEG C) rotary evaporation removes moisture, forms the active ingredient of soluble nti-freckle micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made；
S5：Hyaluronic acid solution is added in micropin mould, the horizontal centrifugal 5min under 1000rpm；Mould is taken out,
Turn clockwise 90 ° and place, 2min is rotated with 100rpm；Mould is taken out into 90 ° of rotate counterclockwise, again the water under 1000rpm
Flat centrifugation 5min；So it is repeated 2 times；Mould is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble nti-freckle micropin in step S3 is added to the mould containing surrounding layer in step S5
In, dry again, be stripped after drying and produce soluble nti-freckle micropin.
Further, the soluble nti-freckle micropin is cone or triangle.
Further, the height of the soluble nti-freckle micropin is 50-500 μm, and preferably ground level is 75-300 μm, more excellent
Selection of land is 100-200 μm.
Compared with prior art, the present invention at least has advantages below：
1. the active ingredient in the present invention, by selecting the height of various medicine for removing speckle and carrying out best of breed, so as to
The dosage and toxic side effect of every kind of medicine are reduced, expands its safe range and use range.
2. the Scutellaria galerioulata L extract in active ingredient of the present invention, Ou Jing certain herbaceous plants with big flowers extracts, peppery mint extract, chrysanthemum nine are taken turns
Careless extract, garment or robe made of feathers leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil extract and all even hair
The Chinese medical extracts such as sharp tea extraction, then it is equipped with tranexamic acid, urea, citric acid, soluble collagen, xanthans, Argireline -2, nine
Peptide -1, the metabolism of skin can be improved while nti-freckle, improve the microenvironment around color spot skin, fundamentally dispel
Spot so that color spot no longer recurs.
3. soluble nti-freckle micropin provided by the invention has biodegradable, it can be completely dissolved or drop in skin
Solution.Prepare surrounding layer using hyaluronic acid, on the one hand can protect active ingredient, avoid active ingredient contact external environment and by
Oxidation is rotten etc.；On the other hand, hyaluronic acid can dissolve rapidly, discharge the active ingredient of the inside, and the soluble nti-freckle is micro-
Needle set has certain slow release effect.
4. soluble nti-freckle micropin provided by the invention can dissolve rapidly inside skin, reach " focus "-color spot skin
It near skin, compared with oral conditioning, can significantly shorten treatment time, avoid medicine from being absorbed through gastrointestinal disturbances and lower active ingredient
Content, or because the dosage of big active ingredient must not be not added with ensureing the content of active ingredient, improve cost；With being directly coated with skin
Conditioning is compared, and soluble nti-freckle micropin provided by the invention can directly reach " focus ", avoid resistance of the skin to active ingredient
Gear, and because skin absorption is slower, active ingredient is oxidized destruction and failed etc..
5. soluble nti-freckle micropin provided by the invention can be completely dissolved so that active ingredient free of losses, be improved effective
The utilization rate of composition, directly applied to near color spot skin, directly improve the metabolism with color spot skin,
Efficiency high, cost is low, can avoid active ingredient that other positions are caused with unnecessary stimulation.
6. nti-freckle micropin provided by the invention is readily produced, transports and stored, cost is reduced.
7. nti-freckle micropin provided by the invention coordinates corresponding instrument, or without instrument, be in can Self-operating, nothing
Beauty parlor need to be gone to.Both safety, but it is time saving, economical.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, below to the technical side in the embodiment of the present invention
Case is clearly and completely described, it is clear that described embodiment is part of the embodiment of the present invention, rather than whole realities
Apply example.Therefore, the scope of claimed invention is not intended to limit to the detailed description of embodiments of the invention below, and
It is the selected embodiment for being merely representative of the present invention.Based on the embodiment in the present invention, those of ordinary skill in the art are not making
Go out under the premise of creative work the every other embodiment obtained, belong to the scope of protection of the invention.
Below by specific embodiment, the present invention is further illustrated.
Extract in the present invention：Refer to a kind of by soaking or being mixed in solvent the material of extract to be obtained
The solution for extracting and obtaining.Extraction process can be carried out with the help of the suitable solvent of selection, such as：Water, ethanol, ethanol/water
Mixture, methanol, propyl alcohol, butanol, chloroform, acetone or other organic solvents, and by isolating, being percolated, decocting, counter-current extraction,
Ultrasonic wave, microwave, the method for supercritical fluid extraction obtain extract, and extract is further concentrated by evaporation, and obtain medicinal extract and do
Dry extract.
In the formula of the present invention, the characteristics of each component and function is as follows：
Scutellaria galerioulata L (scutellaria galericulata)：For a kind under lamiaceae labiatae scutellaria.Effect：Heat-clearing
Eliminating dampness.Cure mainly：Control it is damp and hot, such as damp-warm syndrome, jaundice, rush down dysentery, heat gonorrhea, carbuncle sore tumefacting virus etc.；Also it is used for cough with lung heat, caused by the interior high Sheng of heat
Spitting of blood, haematemesis, bleeding from five sense organs or subcutaneous tissue etc..Nature and flavor：Hardship, tremble with fear.Return lung, stomach, large intestine three pass through.
Radix Malvae sylvestris (malva sylvestris)：Perennial herb plant, for coughing with a lot of sputum or cough up phlegm it is not well,
The cards such as chest diaphragm ruffian is vexed, pharyngalgia sound is mute.Nature and flavor：It is pungent, put down.Enter lung channel.
Cowslip (primula veris) is Ofthe Primulaceae.For the Huang used as extraction raw material
Nine wheel grass positions are spent, are not particularly limited, can suitably be selected according to purpose, such as can be enumerated, flower, bud, fruit, fruit
Skin, seed, kind skin, stem, leaf, branch, branches and leaves, trunk, bark, root, rhizome, root skin or their mixture etc..Wherein, especially
It is preferred that leaf.
Garment or robe made of feathers grass (Alchemilla japonica) is the plant of rose family Alchemilla Linn.From Alps plant plumage
The elite thing being obtained by extraction in clothing grass, in vitro, in vitro with show to suppress in experiment in vivo to participate in melanin biology
The activity of the tyrosinase of synthesis, from source prevention, barrier pigment color spot formed, can more make most obstinate age spot it is thin out, become
It is small, whitening while anti-aging.
Veronica officinalis (Veronica didyma Tenore) 1 year is to biennial herb plant.Major function：Cool blood
Hemostasis, regulating qi-flowing for relieving pain.For spitting blood, hernia, orchitis, leukorrhea.Main Ingredients and Appearance is：Forulic acid, 3-O- acetyloleanolic acids, 3,
4- dimethyl cinnamic acid, daucosterol, cupreol, mannitol etc..
Sweet mary (Melissa officinalis) perennial herb, herb can make stimulant or laxative；It is used for head
Pain and toothache.Chemical composition is containing citral (Citral), linalool (linalool), geraniol (geraniol), citronellal
(citronellal), terpene sour (terpenic acid), tannin, polymerized polyphenolic class, class flavine and triterpene (triterpenes) etc.
Composition.Its pharmacological action includes eliminating cat fever and cough, tool wind dispelling, anti-spasm, stomachache, sweating and sedation etc..
Common milfoil (achillea millefolium) belongs to Achillea.With purify the blood, diuresis, sweating, improve chilly,
Hypertension, vegetative dystonie, climacteric obstacle, blackspot and other effects.
Peppery peppermint (mentha piperita)：Acrid flavour；It is cool in nature.Channel tropism：Lung；Liver Channel.Major function：Dispelling wind and heat from the body；Removing toxic substances
Dissipating bind.Peppery Herba Menthae Haplocalycis volatile oil has killing or inhibiting effect to staphylococcus, streptococcus and sarcine etc..
All equal high-quality green tea tea extraction：Contain abundant protein, amino acid, alkaloid, Tea Polyphenols, sugared point, organic acid, virtue
Studies of The Aromatic Substances and vitamin A, B1, B2, C, K, P, PP etc. and water-soluble minerals.
Other materials or product in the present invention, be it is commercially available, unless otherwise indicated.
The present invention provides a kind of soluble nti-freckle micropin, including active ingredient, and in parts by weight, active ingredient includes：
Tranexamic acid 1.5-32 parts, urea 3-10 parts, citric acid 0.2-1.5 parts, soluble collagen 10-33 parts, xanthans 15-40 parts, six
Victory 16-67 parts of peptide -2, the 8-56 parts of nonapeptide -1, Scutellaria galerioulata L extract 2-14 parts, Ou Jing certain herbaceous plants with big flowers extract 5-18 parts, peppery peppermint carry
Take thing 7-30 parts, cowslip extract 16-43 parts, garment or robe made of feathers leaf extract 0.5-5 parts, veronica officinalis extract 0.5-
5 parts, sweet mary leaf extract 15-36 parts, common milfoil extract 13-53 parts.
Preferably, in parts by weight, active ingredient includes：Tranexamic acid 5-26 parts, urea 5-8 parts, citric acid 0.5-1.3
Part, soluble collagen 14-26 parts, xanthans 19-27 parts, the 24-53 parts of Argireline -2, the 17-33 parts of nonapeptide -1, Scutellaria galerioulata L carry
Take thing 5-13 parts, Ou Jing certain herbaceous plants with big flowers extract 8-14 parts, peppery mint extract 13-24 parts, cowslip extract 23-37 parts, plumage
Clothing leaf extract 0.5-3 parts, veronica officinalis extract 1-4 parts, sweet mary leaf extract 22-30 parts, common milfoil extract
19-47 parts.
It is highly preferred that in parts by weight, in addition to Duyun Maojian Tea extract 8-22 parts.
Soluble nti-freckle micropin provided by the invention also includes surrounding layer.Surrounding layer mainly uses hyaluronic acid.Hyalomitome
Acid shows a variety of important physiological functions with its unique molecular structure and physicochemical property in body, such as lubricating joint, adjusts
Save the permeability of vascular wall, regulatory protein matter, Water-Electrolyte diffusion and operating, promotion, acceleration of wound healing etc..Certain surrounding layer
Other high polymer materials can be used, as vinyl pyrrolidone and its monomer-polymer or copolymer of derivative, ethyl are fine
Dimension element, hyaluronic acid, glucan, soluplus (Polyvinylcaprolactames-polyvinyl acetate-polyethylene glycol graft copolymerization
Thing), hydroxypropyl methylcellulose, methacrylic acid copolymer, quaternary amine methacrylic acid copolymer, PLA, polyglycolic acid, peptides
One or more in chondroitin, collagen, chitosan, amylopectin, polysaccharide polymer etc..
The preparation method of above-mentioned soluble nti-freckle micropin, is mainly included the following steps that：
S1：Prepare Scutellaria galerioulata L extract, Ou Jing certain herbaceous plants with big flowers extracts, peppery mint extract, cowslip extract, the garment or robe made of feathers
Leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil extract and Duyun Maojian Tea extract, it is standby
With.
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Ou Jing certain herbaceous plants with big flowers extracts, peppery peppermint are weighed respectively
Extract, cowslip extract, garment or robe made of feathers leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil
Extract and Duyun Maojian Tea extract, deionized water 300-400 parts are added, is mixed evenly, filters to take filtrate.
S3：According to parts by weight weigh tranexamic acid, urea, citric acid, soluble collagen, xanthans, Argireline -2, nonapeptide -
1st, decoyl salicylic acid, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, the filtrate described in step S2 is added it to
In, it is well mixed, low temperature (less than 40 DEG C) rotary evaporation removes moisture, forms the active ingredient of soluble nti-freckle micropin.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made, preferably
The hyaluronic acid solution of 18% mass concentration.
S5：Hyaluronic acid solution is added in micropin mould, 1000rpm horizontal centrifugals 5min；Mould is taken out, up time
Pin is rotated by 90 ° placement, and 2min is rotated with 100rpm；Mould is taken out into 90 ° of rotate counterclockwise, again 1000rpm horizontal centrifugals
5min；So it is repeated 2 times；Mould is taken out, is dried, completes the preparation of surrounding layer.
S6：The active ingredient of soluble nti-freckle micropin in step S3 is added to the mould containing surrounding layer in step S5
In, dry again, be stripped after drying and produce soluble nti-freckle micropin.
Soluble micropin can be cone or triangle, preferably cone, more conducively through skin.It is and soluble micro-
The height of pin is 50-500 μm.
Embodiment 1
The present embodiment provides a kind of soluble nti-freckle micropin, and in parts by weight, active ingredient includes：1.5 parts of tranexamic acid,
3 parts of urea, 0.2 part of citric acid, 10 parts of soluble collagen, 40 parts of xanthans, -216 parts of Argireline, 56 parts of nonapeptide -1, helmet shape are yellow
14 parts of a kind of reed mentioned in ancient books extract, 18 parts of Ou Jing certain herbaceous plants with big flowers extract, peppery 7 parts of mint extract, 16 parts of cowslip extract, garment or robe made of feathers blade of grass carries
Take 0.5 part of thing, 0.5 part of veronica officinalis extract, 15 parts of sweet mary leaf extract, 53 parts of common milfoil extract, decoyl bigcatkin willow
7 parts of acid, 0.2 part of sodium hydroxide, 50 parts of mandelic acid, 1,2- 3 parts of hexylene glycol, pungent 1 part of glycol.
The preparation method of above-mentioned soluble nti-freckle micropin, comprises the following steps：
S1：Prepare Scutellaria galerioulata L extract, Ou Jing certain herbaceous plants with big flowers extracts, peppery mint extract, cowslip extract, the garment or robe made of feathers
Leaf extract, veronica officinalis extract, sweet mary leaf extract and common milfoil extract, it is standby；
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Ou Jing certain herbaceous plants with big flowers extracts, peppery peppermint are weighed respectively
Extract, cowslip extract, garment or robe made of feathers leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil
Extract, 300 parts of deionized water is added, is mixed evenly, filters to take filtrate；
S3：According to parts by weight weigh tranexamic acid, urea, citric acid, soluble collagen, xanthans, Argireline -2, nonapeptide -
1st, decoyl salicylic acid, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, the filtrate described in step S2 is added it to
In, it is well mixed, 35 DEG C of rotary evaporations remove moisture, form the active ingredient of soluble nti-freckle micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15% mass concentration is made；
S5：Hyaluronic acid solution is added in micropin mould, the horizontal centrifugal 5min under 1000rpm；Mould is taken out,
Turn clockwise 90 ° and place, 2min is rotated with 100rpm；Mould is taken out into 90 ° of rotate counterclockwise, again the water under 1000rpm
Flat centrifugation 5min；So it is repeated 2 times；Mould is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble nti-freckle micropin in step S3 is added to the mould containing surrounding layer in step S5
In, dry again, be stripped after drying and produce soluble nti-freckle micropin.The soluble nti-freckle micropin is cone, is highly 50 μm.
Embodiment 2
The present embodiment provides a kind of soluble nti-freckle micropin, and in parts by weight, active ingredient includes：32 parts of tranexamic acid,
10 parts of urea, 1.5 parts of citric acid, 33 parts of soluble collagen, 15 parts of xanthans, -216 parts of Argireline, 8 parts of nonapeptide -1, helmet shape are yellow
2 parts of a kind of reed mentioned in ancient books extract, 5 parts of Ou Jing certain herbaceous plants with big flowers extract, peppery 30 parts of mint extract, 43 parts of cowslip extract, garment or robe made of feathers blade of grass carries
Take 5 parts of thing, 0.5 part of veronica officinalis extract, 36 parts of sweet mary leaf extract, 13 parts of common milfoil extract, Duyun Maojian Tea
8 parts of extract, 30 parts of decoyl salicylic acid, 1.8 parts of sodium hydroxide, 75 parts of mandelic acid, 1,2- 8 parts of hexylene glycol, pungent 3 parts of glycol.
The preparation method of above-mentioned soluble nti-freckle micropin, comprises the following steps：
S1：Prepare Scutellaria galerioulata L extract, Ou Jing certain herbaceous plants with big flowers extracts, peppery mint extract, cowslip extract, the garment or robe made of feathers
Leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil extract and Duyun Maojian Tea extract, it is standby
With；
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Ou Jing certain herbaceous plants with big flowers extracts, peppery peppermint are weighed respectively
Extract, cowslip extract, garment or robe made of feathers leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil
Extract and Duyun Maojian Tea extract, 400 parts of deionized water is added, is mixed evenly, filters to take filtrate；
S3：According to parts by weight weigh tranexamic acid, urea, citric acid, soluble collagen, xanthans, Argireline -2, nonapeptide -
1st, decoyl salicylic acid, sodium hydroxide, mandelic acid, 1,2- hexylene glycol and pungent glycol, add it to the filtrate described in step S2
In, it is well mixed, 36 DEG C of rotary evaporations remove moisture, form the active ingredient of soluble nti-freckle micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 18% mass concentration is made；
S5：Hyaluronic acid solution is added in micropin mould, the horizontal centrifugal 5min under 1000rpm；Mould is taken out,
Turn clockwise 90 ° and place, 2min is rotated with 100rpm；Mould is taken out into 90 ° of rotate counterclockwise, again the water under 1000rpm
Flat centrifugation 5min；So it is repeated 2 times；Mould is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble nti-freckle micropin in step S3 is added to the mould containing surrounding layer in step S5
In, dry again, be stripped after drying and produce soluble nti-freckle micropin.The soluble nti-freckle micropin is triangle, is highly 300 μ
m。
Embodiment 3
The present embodiment provides a kind of soluble nti-freckle micropin, and in parts by weight, active ingredient includes：5 parts of tranexamic acid, urine
5 parts of element, 0.5 part of citric acid, 14 parts of soluble collagen, 19 parts of xanthans, 24 parts of Argireline -2,17 parts of nonapeptide -1, helmet shape are yellow
5 parts of a kind of reed mentioned in ancient books extract, 8 parts of Ou Jing certain herbaceous plants with big flowers extract, peppery 13 parts of mint extract, 23 parts of cowslip extract, garment or robe made of feathers blade of grass carries
Take 0.5 part of thing, 1 part of veronica officinalis extract, 22 parts of sweet mary leaf extract, 19 parts of common milfoil extract, tippy tea extraction
12 parts of thing, 9 parts of decoyl salicylic acid, 0.8 part of sodium hydroxide, 53 parts of mandelic acid, 1,2- 4 parts of hexylene glycol, and 2 parts of pungent glycol.
The preparation method of above-mentioned soluble nti-freckle micropin, comprises the following steps：
S1：Prepare Scutellaria galerioulata L extract, Ou Jing certain herbaceous plants with big flowers extracts, peppery mint extract, cowslip extract, the garment or robe made of feathers
Leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil extract and Duyun Maojian Tea extract, it is standby
With；
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Ou Jing certain herbaceous plants with big flowers extracts, peppery peppermint are weighed respectively
Extract, cowslip extract, garment or robe made of feathers leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil
Extract and Duyun Maojian Tea extract, 330 parts of deionized water is added, is mixed evenly, filters to take filtrate；
S3：According to parts by weight weigh tranexamic acid, urea, citric acid, soluble collagen, xanthans, Argireline -2, nonapeptide -
1st, decoyl salicylic acid, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, the filtrate described in step S2 is added it to
In, it is well mixed, 37 DEG C of rotary evaporations remove moisture, form the active ingredient of soluble nti-freckle micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15% mass concentration is made；
S5：Hyaluronic acid solution is added in micropin mould, the horizontal centrifugal 5min under 1000rpm；Mould is taken out,
Turn clockwise 90 ° and place, 2min is rotated with 100rpm；Mould is taken out into 90 ° of rotate counterclockwise, again the water under 1000rpm
Flat centrifugation 5min；So it is repeated 2 times；Mould is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble nti-freckle micropin in step S3 is added to the mould containing surrounding layer in step S5
In, dry again, be stripped after drying and produce soluble nti-freckle micropin.The soluble nti-freckle micropin is cone, is highly 100 μ
m。
Embodiment 4
The present embodiment provides a kind of soluble nti-freckle micropin, and in parts by weight, the active ingredient includes：Tranexamic acid 26
Part, 8 parts of urea, 1.3 parts of citric acid, 26 parts of soluble collagen, 27 parts of xanthans, 53 parts of Argireline -2,33 parts of nonapeptide -1, helmet
13 parts of shape Baical Skullcap root P.E, 14 parts of Ou Jing certain herbaceous plants with big flowers extract, peppery 24 parts of mint extract, 37 parts of cowslip extract, the garment or robe made of feathers
3 parts of leaf extract, 4 parts of veronica officinalis extract, 30 parts of sweet mary leaf extract, 47 parts of common milfoil extract, all even hair
Sharp 22 parts of tea extraction, 30 parts of decoyl salicylic acid, 1.8 parts of sodium hydroxide, 75 parts of mandelic acid, 1,2- 8 parts of hexylene glycol, pungent glycol 3
Part.
The preparation method of above-mentioned soluble nti-freckle micropin, comprises the following steps：
S1：Prepare Scutellaria galerioulata L extract, Ou Jing certain herbaceous plants with big flowers extracts, peppery mint extract, cowslip extract, the garment or robe made of feathers
Leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil extract and Duyun Maojian Tea extract, it is standby
With；
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Ou Jing certain herbaceous plants with big flowers extracts, peppery peppermint are weighed respectively
Extract, cowslip extract, garment or robe made of feathers leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil
Extract and Duyun Maojian Tea extract, 380 parts of deionized water is added, is mixed evenly, filters to take filtrate；
S3：According to parts by weight weigh tranexamic acid, urea, citric acid, soluble collagen, xanthans, Argireline -2, nonapeptide -
1st, decoyl salicylic acid, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, the filtrate described in step S2 is added it to
In, it is well mixed, 37 DEG C of rotary evaporations remove moisture, form the active ingredient of soluble nti-freckle micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 20% mass concentration is made；
S5：Hyaluronic acid solution is added in micropin mould, the horizontal centrifugal 5min under 1000rpm；Mould is taken out,
Turn clockwise 90 ° and place, 2min is rotated with 100rpm；Mould is taken out into 90 ° of rotate counterclockwise, again the water under 1000rpm
Flat centrifugation 5min；So it is repeated 2 times；Mould is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble nti-freckle micropin in step S3 is added to the mould containing surrounding layer in step S5
In, dry again, be stripped after drying and produce soluble nti-freckle micropin.The soluble nti-freckle micropin is cone, is highly 500 μ
m。
Embodiment 5
The present embodiment provides a kind of soluble nti-freckle micropin, and in parts by weight, active ingredient includes：16 parts of tranexamic acid,
5 parts of urea, 1 part of citric acid, 20 parts of soluble collagen, 23 parts of xanthans, 35 parts of Argireline -2,27 parts of nonapeptide -1, helmet shape are yellow
9 parts of a kind of reed mentioned in ancient books extract, 12 parts of Ou Jing certain herbaceous plants with big flowers extract, peppery 18 parts of mint extract, 32 parts of cowslip extract, garment or robe made of feathers blade of grass carries
Take 1.8 parts of thing, 2 parts of veronica officinalis extract, 26 parts of sweet mary leaf extract, 29 parts of common milfoil extract, Duyun Maojian Tea
22 parts of extract, 26 parts of decoyl salicylic acid, 1.5 parts of sodium hydroxide, 66 parts of mandelic acid, 1,2- 7 parts of hexylene glycol, pungent 3 parts of glycol.
The preparation method of above-mentioned soluble nti-freckle micropin, comprises the following steps：
S1：Prepare Scutellaria galerioulata L extract, Ou Jing certain herbaceous plants with big flowers extracts, peppery mint extract, cowslip extract, the garment or robe made of feathers
Leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil extract and Duyun Maojian Tea extract, it is standby
With；
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Ou Jing certain herbaceous plants with big flowers extracts, peppery peppermint are weighed respectively
Extract, cowslip extract, garment or robe made of feathers leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil
Extract and Duyun Maojian Tea extract, 400 parts of deionized water is added, is mixed evenly, filters to take filtrate；
S3：According to parts by weight weigh tranexamic acid, urea, citric acid, soluble collagen, xanthans, Argireline -2, nonapeptide -
1st, decoyl salicylic acid, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, the filtrate described in step S2 is added it to
In, it is well mixed, 38 DEG C of rotary evaporations remove moisture, form the active ingredient of soluble nti-freckle micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 18% mass concentration is made；
S5：Hyaluronic acid solution is added in micropin mould, the horizontal centrifugal 5min under 1000rpm；Mould is taken out,
Turn clockwise 90 ° and place, 2min is rotated with 100rpm；Mould is taken out into 90 ° of rotate counterclockwise, again the water under 1000rpm
Flat centrifugation 5min；So it is repeated 2 times；Mould is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble nti-freckle micropin in step S3 is added to the mould containing surrounding layer in step S5
In, dry again, be stripped after drying and produce soluble nti-freckle micropin.The soluble nti-freckle micropin is cone, is highly 200 μ
m。
Below with the exemplary application example for introducing product of the present invention of the product prepared in embodiment 5.The present invention other
Product in embodiment has similar effect.
The present invention have selected age bracket as 25-55 year, face suffers from different degrees of color spot from numerous volunteers
300 volunteers, color spot include freckle, and chloasma, butterfly macules, sunburn, cyasma, rebound spot, hereditary spot, chloasma hepaticum, and acne are dark
Sore etc., wherein M-F respectively account for half and carry out contrast test.300 volunteers are randomly divided into three groups, A groups, B groups and C groups,
Men and women volunteer's number in every group is identical, and the number of each age group is essentially identical.Volunteer in A groups is real using the present invention
The product prepared in example 5 is applied, weekly using once, is only washed one's face daily with clear water；Volunteer in B groups uses whitening and spot eliminating cream
(it is commercially available, there is the effect of desalination color spot, unisex), washed one's face with clear water, used before sleeping at night daily；Aspiration in C groups
Person is washed one's face using clear water, without other any skin-protection products.After tracking 6 months, its result is as follows：
Product Piglet s colibacillosis in the embodiment of the present invention 5 of table 1
Wherein, criterion of therapeutical effect is：Recovery from illness：Face's spot disappears substantially；It is effective：Face's spot regression more than 50%；Effectively：
Face's spot regression more than 10% or spot colors turn light；It is invalid：It is unchanged or more serious before and after treatment.
The product that the offer of the embodiment of the present invention 5 is can be seen that from the experimental result in table 1 is substantially better than commercially available prod.With
After track six months, in A groups, the product that is provided using the embodiment of the present invention 5 can effective nti-freckle, cure rate reaches
93%, the volunteer not cured, it is obviously improved, and it is longer that it cures the time needed.In B groups, use is commercially available
Whitening and freckle-removing product, color spot can cure than thin and shorter time of occurrence volunteer, and color spot is serious, time of occurrence
Long volunteer is substantially without obvious effect.
Soluble nti-freckle micropin provided by the invention, freckle effect is obvious, efficiency high, and is capable of the new old of conditioning skin
Metabolism so that skin recovers normal physiological function, and fundamentally nti-freckle, no longer recurs.During tracking, the present invention is used
The volunteer of the product provided in embodiment 5, its whole skin, which all has, to improve significantly, and skin is more smooth thin than before
It is greasy, more glossy, high resilience.
More than, it is only the preferable embodiment of the present invention, but the protection domain invented is not limited thereto, and it is any ripe
Know those skilled in the art the invention discloses technical scope in, the change or replacement that can readily occur in should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention should be defined by the protection domain of claims.
Claims (10)
1. a kind of soluble nti-freckle micropin, it is characterised in that including active ingredient, in parts by weight, the active ingredient bag
Include：
Tranexamic acid 1.5-32 parts, urea 3-10 parts, citric acid 0.2-1.5 parts, soluble collagen 10-33 parts, xanthans 15-40
Part, the 16-67 parts of Argireline -2, the 8-56 parts of nonapeptide -1, Scutellaria galerioulata L extract 2-14 parts, Ou Jing certain herbaceous plants with big flowers extract 5-18 parts are peppery
Mint extract 7-30 parts, cowslip extract 16-43 parts, garment or robe made of feathers leaf extract 0.5-5 parts, veronica officinalis extraction
Thing 0.5-5 parts, sweet mary leaf extract 15-36 parts, common milfoil extract 13-53 parts.
2. soluble nti-freckle micropin according to claim 1, it is characterised in that in parts by weight, the active ingredient
Including：Tranexamic acid 5-26 parts, urea 5-8 parts, citric acid 0.5-1.3 parts, soluble collagen 14-26 parts, xanthans 19-27 parts,
The 24-53 parts of Argireline -2, the 17-33 parts of nonapeptide -1, Scutellaria galerioulata L extract 5-13 parts, Ou Jing certain herbaceous plants with big flowers extract 8-14 parts are peppery thin
Lotus extract 13-24 parts, cowslip extract 23-37 parts, garment or robe made of feathers leaf extract 0.5-3 parts, veronica officinalis extraction
Thing 1-4 parts, sweet mary leaf extract 22-30 parts, common milfoil extract 19-47 parts.
3. soluble nti-freckle micropin according to claim 2, it is characterised in that in parts by weight, the active ingredient
Including：16 parts of tranexamic acid, 5 parts of urea, 1 part of citric acid, 20 parts of soluble collagen, 23 parts of xanthans, 35 parts of Argireline -2, nine
27 parts of peptide -1,9 parts of Scutellaria galerioulata L extract, 12 parts of Ou Jing certain herbaceous plants with big flowers extract, peppery 18 parts of mint extract, cowslip extraction
32 parts of thing, 1.8 parts of garment or robe made of feathers leaf extract, 2 parts of veronica officinalis extract, 26 parts of sweet mary leaf extract, common milfoil extraction
29 parts of thing.
4. the soluble nti-freckle micropin according to any one of claim 1-3, it is characterised in that in parts by weight, also
Including Duyun Maojian Tea extract 8-22 parts.
5. the soluble nti-freckle micropin according to any one of claim 1-3, it is characterised in that also including decoyl salicylic acid
7-30 parts, sodium hydroxide 0.2-1.8 parts, mandelic acid 50-75 parts, 1,2- hexylene glycol 3-8 parts, pungent glycol 1-3 parts.
6. the soluble nti-freckle micropin according to any one of claim 1-3, it is characterised in that also including surrounding layer, group
Material into surrounding layer is selected from the monomer-polymer or copolymer of vinyl pyrrolidone and its derivative, ethyl cellulose, thoroughly
Bright matter acid, glucan, soluplus, hydroxypropyl methylcellulose, methacrylic acid copolymer, quaternary amine methacrylic acid copolymer,
One or more in PLA, polyglycolic acid, peptides chondroitin, collagen, chitosan, amylopectin, polysaccharide polymer.
7. soluble nti-freckle micropin according to claim 6, it is characterised in that the material for forming surrounding layer is hyalomitome
Acid, the mass concentration of the hyaluronic acid is 15% ~ 20%.
8. the preparation method of the soluble nti-freckle micropin described in a kind of claim 1, it is characterised in that comprise the following steps：
S1：Prepare Scutellaria galerioulata L extract, Ou Jing certain herbaceous plants with big flowers extracts, peppery mint extract, cowslip extract, garment or robe made of feathers blade of grass
Extract, veronica officinalis extract, sweet mary leaf extract, common milfoil extract and Duyun Maojian Tea extract, it is standby；
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Ou Jing certain herbaceous plants with big flowers extracts, peppery peppermint extraction are weighed respectively
Thing, cowslip extract, garment or robe made of feathers leaf extract, veronica officinalis extract, sweet mary leaf extract, common milfoil extraction
Thing and Duyun Maojian Tea extract, deionized water 300-400 parts are added, is mixed evenly, filters to take filtrate；
S3：Tranexamic acid, urea, citric acid, soluble collagen, xanthans, Argireline -2, nonapeptide -1, pungent is weighed according to parts by weight
Acyl salicylic acid, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, pungent glycol, add it in the filtrate described in step S2, mix
Close uniform, low temperature（Less than 40 DEG C）Rotary evaporation removes moisture, forms the active ingredient of soluble nti-freckle micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made；
S5：Hyaluronic acid solution is added in micropin mould, the horizontal centrifugal 5min under 1000rpm；Mould is taken out, up time
Pin is rotated by 90 ° placement, and 2min is rotated with 100rpm；By mould take out 90 ° of rotate counterclockwise, again under 1000rpm level from
Heart 5min；So it is repeated 2 times；Mould is taken out, is dried, completes the preparation of surrounding layer；
S6：The active ingredient of soluble nti-freckle micropin in step S3 is added in step S5 in the mould containing surrounding layer,
Dry again, be stripped after drying and produce soluble nti-freckle micropin.
9. soluble nti-freckle micropin according to claim 8, it is characterised in that the soluble nti-freckle micropin is circular cone
Shape or triangle.
10. soluble nti-freckle micropin according to claim 8, it is characterised in that the height of the soluble nti-freckle micropin
Spend for 50-500 μm.
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| CN201710842626.0A CN107569421A (en) | 2017-09-18 | 2017-09-18 | A kind of soluble nti-freckle micropin |
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