CN108210434A - A kind of soluble reparation scar micropin and preparation method thereof - Google Patents

A kind of soluble reparation scar micropin and preparation method thereof Download PDF

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Publication number
CN108210434A
CN108210434A CN201810167837.3A CN201810167837A CN108210434A CN 108210434 A CN108210434 A CN 108210434A CN 201810167837 A CN201810167837 A CN 201810167837A CN 108210434 A CN108210434 A CN 108210434A
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parts
extract
scar
soluble
micropin
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陈彦彪
唐骢
陈家骊
王锦涛
陈御钗
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

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Abstract

The invention discloses a kind of soluble reparation scar micropins, and including active ingredient, in parts by weight, the active ingredient includes：0.2 1.5 parts of citric acid, 10 33 parts of soluble collagen, 2 14 parts of Scutellaria galerioulata L extract, 5 18 parts of Radix Malvae sylvestris extract, peppery 7 30 parts of mint extract, 0.5 5 parts of veronica officinalis extract, 13 53 parts of common milfoil extract, 50 130 parts of purslane extract, 50 100 parts of Radix Arnebiae extract, 50 100 parts of nutgall extractive, 70 90 parts of Myrrha extract, 15 20 parts of Borneolum Syntheticum extract, 12 15 parts of aloe extract, 36 parts of yam extract, 12 15 parts of chamomile extract, 12 parts of glycine betaine, 36 parts of Burdok root P.E, 13 parts of mung bean powder extracts, 48 parts of Radix Codonopsis extract, 89 parts of carrot seed essential oil, 67 parts of Lavender.This micropin is repaired scar and was repaiied significantly.

Description

A kind of soluble reparation scar micropin and preparation method thereof
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of soluble reparation scar micropin and preparation method thereof.
Background technology
" scar " be the detrimental effect of the factors such as physics, biology, chemistry in human skin soft tissue, lead to skin soft tissue Major injury and completely voluntarily normal cannot repair, the i.e. influence appearance for turning to be left by fibrous tissue replacement reparation influences work(again The local symptom of energy.What " scar " was brought to patient is huge human body pain and mental suffering, especially burns, scalds, is tight The scar left after weight wound.Several years of scar hyperplasia phase almost allow patient to suffer untold misery.The atrophy phase then makes trouble again Person is changed beyond recognition, dysfunction, causes the great body of patient, heart double combination obstacle.
Scar mainly includes following several：
1) face is located at the scar near face, and causes face deformation or function limitation system, such as canthus, the corners of the mouth.
2) in the scar of extremities joint, active receiving is caused to limit.
3) long and wide scar.
4) scar of plump protuberance.
5) scar of recess crape folding.
6) pigmentation or color highlight and can not be with the matched scars of neighbouring skin color.
7) the disproportionate scar of dermatoglyph with arround.
8) there is the apparent scar for making us malaise symptoms, such as very itch, is scorching hot, pain or superficial ulcer.
At present, the cosmetics for the treatment of scar are added to chemical bactericide, hormone, astringent, anti-inflammatory agent etc. more in the market, right Skin irritation is big, serious or even cause skin allergy, and since pathogen easily generates drug resistance, ineffective.Therefore, Developing the cosmetics that a kind of safer, mild, lasting and effect comprehensively repairs scar has become the active demand in market.
The cosmetics of scar are repaired at present mainly coated in skin surface, need to absorb active ingredient by skin.Skin The factors such as active ingredient bulk of molecule, solubility are related in the absorption of skin and product, and significant portion active ingredient is not in product It can adequately be utilized or be failed in absorption process by other substances oxidation etc..This is also current cosmetic treatment effect One main cause of fruit difference.
In addition, scar product of dispelling on the market is transported, stored in fluid form mostly at present, liquid storage time is short, no Conducive to transport, easily go mouldy or aoxidize.
Invention content
The main object of the present invention is to provide for a kind of soluble reparation scar micropin and preparation method thereof, existing to solve There is scar to repair product and repair the problem of scar effect is bad.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of soluble reparation scar micropin, including active ingredient, in parts by weight, the active ingredient includes：
0.2-1.5 parts of citric acid, 10-33 parts of soluble collagen, 2-14 parts of Scutellaria galerioulata L extract, Radix Malvae sylvestris extract 5- 18 parts, peppery mint extract 7-30 parts, 0.5-5 parts of veronica officinalis extract, 13-53 parts of common milfoil extract, purslane carries 50-130 parts of object is taken, 50-100 parts of Radix Arnebiae extract, 50-100 parts of nutgall extractive, 70-90 parts of Myrrha extract, borneol carries Take 15-20 parts of object, 12-15 parts of aloe extract, 3-6 parts of yam extract, 12-15 parts of chamomile extract, glycine betaine 1-2 Part, 3-6 parts of Burdok root P.E, 1-3 parts of mung bean powder extracts, Radix Codonopsis extract 4-8 parts, 8-9 parts of carrot seed essential oil smokes clothing Careless essential oil 6-7 parts.
Preferably, in parts by weight, the active ingredient includes：0.5-1 parts of citric acid, 18-25 parts of soluble collagen, 5-10 parts of Scutellaria galerioulata L extract, 10-15 parts of Radix Malvae sylvestris extract, peppery mint extract 18-26 parts, veronica officinalis extract 2-4 parts, 25-40 parts of common milfoil extract, 70-100 parts of purslane extract, 60-85 parts of Radix Arnebiae extract, nutgall extractive 70-80 parts, 75-85 parts of Myrrha extract, 16-18 parts of Borneolum Syntheticum extract, 13-14 parts of aloe extract, yam extract 4-5 Part, 13-14 parts of chamomile extract, 1-2 parts of glycine betaine, 4-5 parts of Burdok root P.E, 1-3 parts of mung bean powder extracts, Radix Codonopsis carries Take 5-6 parts of object, 8-9 parts of carrot seed essential oil, 6-7 parts of Lavender.
Preferably, in parts by weight, the active ingredient includes：0.8 part of citric acid, 20 parts of soluble collagen, helmet shape 8 parts of Baical Skullcap root P.E, 12 parts of Radix Malvae sylvestris extract, peppery 22 parts of mint extract, 3 parts of veronica officinalis extract, common milfoil carries Take 35 parts of object, 85 parts of purslane, 75 parts of Asian puccoon, 75 parts of Chinese gall, 80 parts of myrrh, 17 parts of borneol, 13 parts of aloe, 4.5 parts of Chinese yam, 13.5 parts of chamomile extract, 1.5 parts of glycine betaine, 4.5 parts of radix bardanae, 2 parts of mung bean flour, 5.5 parts of Radix Codonopsis, carrot seed essential oil 8.5 Part, 6.5 parts of Lavender.
Preferably, in parts by weight, 8-22 parts of Duyun Maojian Tea extract is further included.
Preferably, further include 7-30 parts of decoyl salicylic acid, 0.2-1.8 parts of sodium hydroxide, 50-75 parts of mandelic acid, 1,2- oneself 3-8 parts of glycol, pungent glycol 1-3 parts.
Preferably, surrounding layer is further included, the material for forming surrounding layer is selected from the list of vinyl pyrrolidone and its derivative Body polymer or copolymer, ethyl cellulose, hyaluronic acid, glucan, soluplus, hydroxypropyl methylcellulose, methacrylic acid Copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides chondroitin, collagen, chitosan, branch It is one or more in starch, polysaccharide polymer.
Preferably, the material for forming surrounding layer is hyaluronic acid, and the mass concentration of the hyaluronic acid is 15%~20%.
A kind of soluble preparation method for repairing scar micropin described in claim 1, includes the following steps：
S1：Prepare Scutellaria galerioulata L extract, Radix Malvae sylvestris extract, peppery mint extract, veronica officinalis extract, Europe alpine yarrow Careless extract, purslane extract, Radix Arnebiae extract, nutgall extractive, Myrrha extract, Borneolum Syntheticum extract, chamomile extraction Object, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe extract, yam extract and Duyun Maojian Tea is taken to carry Object is taken, it is spare；
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Radix Malvae sylvestris extract, peppery peppermint are weighed respectively Extract, veronica officinalis extract, common milfoil extract, Radix Arnebiae extract, nutgall extractive, do not have purslane extract Medicament extract, Borneolum Syntheticum extract, chamomile extract, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe carry Object, yam extract, Duyun Maojian Tea extract, carrot seed essential oil and Lavender are taken, adds in deionized water 300-400 Part, it is mixed evenly, filters to take filtrate；
S3：Weigh citric acid, soluble collagen, decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- oneself Glycol, pungent glycol are added it in the filtrate described in step S2, are uniformly mixed, and less than 40 DEG C rotary evaporations remove moisture, Form the soluble active ingredient for repairing scar micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made；
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer；
S6：The soluble active ingredient for repairing scar micropin in step S3 is added in step S5 containing surrounding layer It in mold, dries again, is demoulded after dry and repair scar micropin up to soluble.
A kind of solubility repairs the microneedle configuration of scar, and the soluble microneedle configuration for repairing scar includes needle point 1, connects Layer 2 is connect, the needle point 1 is arranged on the articulamentum 2, and 1 outer layer of needle point is provided with surrounding layer 3；The needle point 1 is circular cone Shape or triangle.
Preferably, the height of the needle point 1 is 50-500 microns.
Compared with prior art, the present invention is soluble repairs scar micropin and preparation method thereof at least with following
Advantageous effect：
1) active ingredient in the present invention, by selecting the various height for dispelling scar drug and carrying out optimal combination, so as to The dosage and toxic side effect of each drug are reduced, expands its safe range and use scope.
2) the Scutellaria galerioulata L extract in active ingredient of the present invention, Radix Malvae sylvestris extract, peppery mint extract, medicinal grandmother Receiving extract, common milfoil extract, purslane extract, Radix Arnebiae extract, nutgall extractive, Myrrha extract, borneol carries Take object, chamomile extract, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe extract, yam extract With the Chinese medical extracts such as Duyun Maojian Tea extract, then citric acid, soluble collagen are equipped with, can changed while scar is repaired The metabolism of kind skin, improves the microenvironment around scar skin, fundamentally repairs scar.
3) soluble scar micropin of repairing provided by the invention has biodegradable, can be completely dissolved in skin or Degradation.Prepare surrounding layer using hyaluronic acid, on the one hand can protect active ingredient, avoid active ingredient contact external environment and It is aoxidized or rotten etc.；On the other hand, hyaluronic acid can dissolve rapidly, discharge the active ingredient of the inside, and the solubility is repaired Scar micropin has certain slow release effect.
4) soluble scar micropin of repairing provided by the invention can rapidly dissolve inside skin, reach " lesion "-scar Near trace skin, with it is oral conditioning compared with, can substantially shorten treatment time, avoid drug through gastrointestinal disturbances absorb lower effectively into The dosage of big active ingredient must not be not added with when the content divided or the content because guarantee active ingredient, improves cost；With being directly coated with Skin condition is compared, and soluble scar micropin of repairing provided by the invention can directly reach " lesion ", avoid skin to effective The blocking of ingredient and because skin absorb it is slower, active ingredient is failed by Oxidative demage.
5) soluble scar micropin of repairing provided by the invention can be completely dissolved so that active ingredient free of losses improves The utilization rate of active ingredient is directly applied to near scarred skin, is directly improved new old with scarred skin Metabolism, it is efficient, it is at low cost, active ingredient can be avoided to cause unnecessary stimulation to other positions.
6) reparation scar micropin provided by the invention is readily produced, transports and stores, and reduces cost.
7) reparation scar micropin provided by the invention coordinates corresponding instrument or without instrument, and being in voluntarily to grasp Make, without going to beauty parlor.Not only safety, but it is time saving, economical.
Description of the drawings
Fig. 1 is the soluble structure diagram for repairing scar micropin of the present invention.
Specific embodiment
The invention will be further described with reference to the accompanying drawings and examples, and following embodiment is descriptive, is not Limited, it is impossible to protection scope of the present invention is limited with this.
The purpose, technical scheme and advantage for making the embodiment of the present invention are clearer, below in conjunction in the embodiment of the present invention Attached drawing, the technical solution in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is this Invention part of the embodiment, instead of all the embodiments.Embodiments of the present invention, which are generally described and illustrated herein in the accompanying drawings Component can arrange and design with a variety of different configurations.Therefore, the implementation of the present invention to providing in the accompanying drawings below The detailed description of example is not intended to limit the range of claimed invention, but is merely representative of the selected implementation of the present invention Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts Every other embodiment, shall fall within the protection scope of the present invention.
The embodiment of the present invention is described below in detail, the example of the embodiment is shown in the drawings, wherein from beginning to end Same or similar label represents same or similar element or the element with same or like function.Below with reference to attached The embodiment of figure description is exemplary, it is intended to for explaining the present invention, and is not considered as limiting the invention.
Extract in the present invention：Refer to a kind of by impregnating or being mixed in solvent by the substance of extract to be obtained The solution for extracting and obtaining.Extraction process can carry out with the help of the suitable solvent of selection, such as：Water, ethyl alcohol, ethanol/water Mixture, methanol, propyl alcohol, butanol, chloroform, acetone or other organic solvents, and pass through isolation, diafiltration, decoction, counter-current extraction, Ultrasonic wave, microwave, supercritical fluid extraction method obtain extract, extract is further concentrated by evaporation, and obtains medicinal extract and dry Dry extract.
In the formula of the present invention, the characteristics of each component and function is as follows：
Scutellaria galerioulata L (scutellaria galericulata)：For one kind under lamiaceae labiatae scutellaria.Effect：Heat-clearing Eliminating dampness.It cures mainly：Control it is damp and hot, such as damp-warm syndrome, jaundice, rush down dysentery, heat gonorrhea, carbuncle sore tumefacting virus etc.；Also for cough with lung heat, caused by the interior high Sheng of heat Spitting of blood, haematemesis, bleeding from five sense organs or subcutaneous tissue etc..Nature and flavor：Hardship is trembled with fear.Return lung, stomach, large intestine three pass through.
Radix Malvae sylvestris (malva sylvestris)：Perennial herb plant, for coughing with a lot of sputum or cough up phlegm it is not well, The cards such as chest diaphragm ruffian is bored, pharyngalgia hoarse voice.Nature and flavor：It is pungent, it puts down.Enter lung channel.
Veronica officinalis (Veronica didyma Tenore) 1 year is to biennial herb plant.Major function：Cool blood Hemostasis, regulating qi-flowing for relieving pain.For spitting blood, hernia, orchitis, leukorrhea.Main ingredient is：Ferulic acid, 3-O- acetyloleanolic acids, 3, 4- dimethyl cinnamic acid, daucosterol, cupreol, mannitol etc..
Common milfoil (achillea millefolium) belongs to Achillea.With purify the blood, diuresis, sweating, improve chilly, Hypertension, vegetative dystonie, climacteric obstacle, blackspot and other effects.
Peppery peppermint (mentha piperita)：Acrid flavour；It is cool in nature.Channel tropism：Lung；Liver Channel.Major function：Dispelling wind and heat from the body；Removing toxic substances Dissipating bind.Peppery Herba Menthae Haplocalycis volatile oil has killing or inhibiting effect to staphylococcus, streptococcus and sarcine etc..
All equal high-quality green tea tea extraction：Contain abundant protein, amino acid, alkaloid, tea polyphenols, sugared point, organic acid, virtue Studies of The Aromatic Substances and vitamin A, B1, B2, C, K, P, PP etc. and water-soluble minerals.
Purslane：Nature and flavor acid, trembles with fear, and primary efficacy is clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body.
Asian puccoon：Nature and flavor are sweet, salty, tremble with fear, and primary efficacy is cool blood, promoting blood circulation, promoting eruption of detoxifying.
Chinese gall：It is nature and flavor acid, puckery, it trembles with fear, primary efficacy is astringes the lung fall fire, relieving diarrhea with astringents, arrest sweating hemostasis, hygroscopic sore.
Myrrh：It is bitter in taste, it puts down, primary efficacy is removing blood stasis and analgesics, externally used detumescence myogenic.
Borneol：Nature and flavor are pungent, bitter, cool, and primary efficacy is to lead to all keys, dissipates stagnated fire, removes screen improving eyesight, swelling and pain relieving.
Chamomile：Chamomile is rich in flavones active component, which has anti-oxidant, anti-inflammatory and other effects, can play very Good anti-sensitization.
Radix bardanae：Radix bardanae is rich in protein and calcium and plant fiber, carrotene etc., and the synergistic effect between each component makes Scar cream of dispelling of the invention is obtained with good scar effect of dispelling, while has whitening function, good biocompatibility, to skin irritation It is small.
Radix Codonopsis：Radix Codonopsis has strengthen immunity, expansion blood vessel, decompression, improves the effects that microcirculation, enhancing hematopoiesis function, tool There is the effect of tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung.
Aloe：Bactericidal effect, anti-inflammatory effect, moisten beautification function, letting out effect under stomach invigorating, cardiac stimulant promoting blood circulation effect, be immunized with Palingenesis, is immunized and antitumor action, detoxication, anti-aging effects ease pain, sedation, anti-sunlight function.
Chinese yam：Chinese yam have nourish it is strong, it is aid digestion, abnormal sweating is held back, the effect of antidiarrheal.
Carrot seed essential oil：Carrot seed seed oil can strengthen red blood cell, it is possible to improve the colour of skin, skin more consolidation is made to have bullet Property.Skin after use youthens vibrant, can also desalinate age spot, be the liberator of early ageing skin.The life of pre- anti-wrinkle Into -- perhaps this is because carrot seed seed oil can facilitate reepithelialization, similarly, this function can also promote wound knot Scar.It is said that other skin problems can also be improved, such as the stream wound of soup and ulcer, hickie, itching, fool, eczema, chronic eczema. The wound of inflammation and skin and the corn of thick and stiff drying can be treated.
Lavender can be clearing heat and detoxicating, cleaning skin, controls oil, repairs scar whitening, and the tender skin of anti-wrinkle dispels eye Bag livid ring around eye may additionally facilitate the skin-protecting functions such as regeneration of damaged tissue recovery.It can purify, pacify soul, mitigate indignation and essence is tired The feeling that power exhausts, making one can be even-tempered and good-humouredly in face of life.
Other materials or product in the present invention, be it is commercially available, unless otherwise indicated.
The present invention provides a kind of soluble reparation scar micropin, including active ingredient, in parts by weight, active ingredient packet It includes：0.2-1.5 parts of citric acid, 10-33 parts of soluble collagen, 2-14 parts of Scutellaria galerioulata L extract, 5-18 parts of Radix Malvae sylvestris extract, Peppery mint extract 7-30 parts, 0.5-5 parts of veronica officinalis extract, 13-53 parts of common milfoil extract, purslane extract 50-130 parts, 50-100 parts of Radix Arnebiae extract, 50-100 parts of nutgall extractive, 70-90 parts of Myrrha extract, Borneolum Syntheticum extract 15-20 parts, 12-15 parts of aloe extract, 3-6 parts of yam extract, 12-15 parts of chamomile extract, 1-2 parts of glycine betaine, ox 3-6 parts of burdock root extract, 1-3 parts of mung bean powder extracts, Radix Codonopsis extract 4-8 parts, 8-9 parts of carrot seed essential oil, Lavender 6-7 parts, 8-22 parts of Duyun Maojian Tea extract, 7-30 parts of decoyl salicylic acid, 0.2-1.8 parts of sodium hydroxide, mandelic acid 50-75 Part, 1,2- 3-8 parts of hexylene glycol, pungent glycol 1-3 parts.
Soluble scar micropin of repairing provided by the invention further includes surrounding layer.Surrounding layer mainly uses hyaluronic acid.Thoroughly Bright matter acid shows a variety of important physiological functions with its unique molecular structure and physicochemical property in body, and such as lubrication is closed Section adjusts the permeability of vascular wall, regulatory protein matter, Water-Electrolyte diffusion and operating, promotion, acceleration of wound healing etc..Certainly Other high molecular materials may be used in surrounding layer, such as vinyl pyrrolidone and its monomer-polymer or copolymer of derivative, Ethyl cellulose, hyaluronic acid, glucan, soluplus (Polyvinylcaprolactames-polyvinyl acetate-polyethylene glycol grafting Copolymer), hydroxypropyl methylcellulose, methacrylic acid copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, One or more of peptides chondroitin, collagen, chitosan, amylopectin, polysaccharide polymer etc..
The above-mentioned soluble preparation method for repairing scar micropin, mainly includes the following steps that：
S1：Prepare Scutellaria galerioulata L extract, Radix Malvae sylvestris extract, peppery mint extract, veronica officinalis extract, Europe alpine yarrow Careless extract, purslane extract, Radix Arnebiae extract, nutgall extractive, Myrrha extract, Borneolum Syntheticum extract, chamomile extraction Object, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe extract, yam extract and Duyun Maojian Tea is taken to carry Object is taken, it is spare.
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Radix Malvae sylvestris extract, peppery peppermint are weighed respectively Extract, veronica officinalis extract, common milfoil extract, Radix Arnebiae extract, nutgall extractive, do not have purslane extract Medicament extract, Borneolum Syntheticum extract, chamomile extract, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe carry Object, yam extract, Duyun Maojian Tea extract, carrot seed essential oil and Lavender are taken, adds in deionized water 300-400 Part, it is mixed evenly, filters to take filtrate.
S3：Weigh citric acid, soluble collagen, decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- oneself Glycol, pungent glycol are added it in the filtrate described in step S2, are uniformly mixed, and less than 40 DEG C rotary evaporations remove moisture, Form the soluble active ingredient for repairing scar micropin.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The soluble active ingredient for repairing scar micropin in step S3 is added in step S5 containing surrounding layer It in mold, dries again, is demoulded after dry and repair scar micropin up to soluble.
A kind of soluble microneedle configuration for repairing scar, including needle point 1, articulamentum 2, the needle point 1 is arranged on the company It connects on layer 2,1 outer layer of needle point is provided with surrounding layer 3；The needle point 1 is cone or triangle.The height of the needle point 1 It is 50-500 microns.
Embodiment 1
The present embodiment provides a kind of soluble reparation scar micropins, and in parts by weight, active ingredient includes：Citric acid 0.8 part, 20 parts of soluble collagen, 8 parts of Scutellaria galerioulata L extract, 12 parts of Radix Malvae sylvestris extract, peppery 22 parts of mint extract is medicinal 3 parts of Veronica extract, 35 parts of common milfoil extract, 85 parts of purslane, 75 parts of Asian puccoon, 75 parts of Chinese gall, 80 parts of myrrh, borneol 17 parts, 13 parts of aloe, 4.5 parts of Chinese yam, 13.5 parts of chamomile extract, 1.5 parts of glycine betaine, 4.5 parts of radix bardanae, 2 parts of mung bean flour, 5.5 parts of Radix Codonopsis, 8.5 parts of carrot seed essential oil, 6.5 parts of Lavender, 10 parts of Duyun Maojian Tea extract, decoyl salicylic acid 7 Part, 0.2 part of sodium hydroxide, 50 parts of mandelic acid, 1,2- 3 parts of hexylene glycol, pungent 1 part of glycol.
The above-mentioned soluble preparation method for repairing scar micropin, includes the following steps：
S1：Prepare Scutellaria galerioulata L extract, Radix Malvae sylvestris extract, peppery mint extract, veronica officinalis extract, Europe alpine yarrow Careless extract, purslane extract, Radix Arnebiae extract, nutgall extractive, Myrrha extract, Borneolum Syntheticum extract, chamomile extraction Object, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe extract, yam extract and Duyun Maojian Tea is taken to carry Object is taken, it is spare.
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Radix Malvae sylvestris extract, peppery peppermint are weighed respectively Extract, veronica officinalis extract, common milfoil extract, Radix Arnebiae extract, nutgall extractive, do not have purslane extract Medicament extract, Borneolum Syntheticum extract, chamomile extract, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe carry Object, yam extract, Duyun Maojian Tea extract, carrot seed essential oil and Lavender are taken, adds in 300 parts of deionized water, is mixed Conjunction stirs evenly, and filters to take filtrate.
S3：Weigh citric acid, soluble collagen, decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- oneself Glycol, pungent glycol are added it in the filtrate described in step S2, are uniformly mixed, and less than 40 DEG C rotary evaporations remove moisture, Form the soluble active ingredient for repairing scar micropin.
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15% mass concentration is made.
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer.
S6：The soluble active ingredient for repairing scar micropin in step S3 is added in step S5 containing surrounding layer It in mold, dries again, is demoulded after dry and repair scar micropin up to soluble.The solubility repairs the microneedle configuration of scar, Including needle point 1, articulamentum 2, the needle point 1 is arranged on the articulamentum 2, and 1 outer layer of needle point is provided with surrounding layer 3；Institute Needle point 1 is stated as cone or triangle, is highly 50 microns.Needle point 1 is connect by articulamentum 2 with external device 4.
Embodiment 2
The present embodiment provides a kind of soluble reparation scar micropins, and in parts by weight, active ingredient includes：Citric acid 1 Part, 15 parts of soluble collagen, 10 parts of Scutellaria galerioulata L extract, 15 parts of Radix Malvae sylvestris extract, peppery 10 parts of mint extract, medicinal mother-in-law 2 parts of procumbent speedwell extract, 20 parts of common milfoil extract, 60 parts of purslane extract, 80 parts of Radix Arnebiae extract, nutgall extractive 80 Part, 75 parts of Myrrha extract, 18 parts of Borneolum Syntheticum extract, 14 parts of aloe extract, 5 parts of yam extract, chamomile extract 13 Part, 1.6 parts of glycine betaine, 5 parts of Burdok root P.E, 1.5 parts of mung bean powder extracts, 5 parts of Radix Codonopsis extract, carrot seed essential oil 8 Part, 6 parts of Lavender, 12 parts of Duyun Maojian Tea extract, 20 parts of decoyl salicylic acid, 0.5 part of sodium hydroxide, mandelic acid 60 Part, 1,2- 5 parts of hexylene glycol, pungent 1.5 parts of glycol.
The above-mentioned soluble preparation method for repairing scar micropin, includes the following steps：
S1：Prepare Scutellaria galerioulata L extract, Radix Malvae sylvestris extract, peppery mint extract, veronica officinalis extract, Europe alpine yarrow Careless extract, purslane extract, Radix Arnebiae extract, nutgall extractive, Myrrha extract, Borneolum Syntheticum extract, chamomile extraction Object, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe extract, yam extract and Duyun Maojian Tea is taken to carry Object is taken, it is spare；
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Radix Malvae sylvestris extract, peppery peppermint are weighed respectively Extract, veronica officinalis extract, common milfoil extract, Radix Arnebiae extract, nutgall extractive, do not have purslane extract Medicament extract, Borneolum Syntheticum extract, chamomile extract, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe carry Object, yam extract, Duyun Maojian Tea extract, carrot seed essential oil and Lavender are taken, adds in 350 parts of deionized water, is mixed Conjunction stirs evenly, and filters to take filtrate；
S3：Weigh citric acid, soluble collagen, decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- oneself Glycol, pungent glycol are added it in the filtrate described in step S2, are uniformly mixed, and less than 40 DEG C rotary evaporations remove moisture, Form the soluble active ingredient for repairing scar micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 18% mass concentration is made；
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer；
S6：The soluble active ingredient for repairing scar micropin in step S3 is added in step S5 containing surrounding layer It in mold, dries again, is demoulded after dry and repair scar micropin up to soluble.The solubility repairs the microneedle configuration of scar, Including needle point 1, articulamentum 2, the needle point 1 is arranged on the articulamentum 2, and 1 outer layer of needle point is provided with surrounding layer 3；Institute Needle point 1 is stated as cone or triangle, is highly 100 microns.Needle point 1 is connect by articulamentum 2 with external device 4.
Embodiment 3
The present embodiment provides a kind of soluble reparation scar micropins, and in parts by weight, active ingredient includes：Citric acid 1.4 parts, 30 parts of soluble collagen, 12 parts of Scutellaria galerioulata L extract, 10 parts of Radix Malvae sylvestris extract, peppery 20 parts of mint extract, medicine With 5 parts of Veronica extract, 50 parts of common milfoil extract, 100 parts of purslane extract, 90 parts of Radix Arnebiae extract, Chinese gall carries Take 100 parts of object, 70 parts of Myrrha extract, 15 parts of Borneolum Syntheticum extract, 12 parts of aloe extract, 6 parts of yam extract, chamomile extraction Take 14 parts of object, 1 part of glycine betaine, 3 parts of Burdok root P.E, 3 parts of mung bean powder extracts, 7 parts of Radix Codonopsis extract, carrot seed essential oil 9 Part, 6 parts of Lavender, 20 parts of Duyun Maojian Tea extract, 15 parts of decoyl salicylic acid, 1 part of sodium hydroxide, 70 parts of mandelic acid, 2 parts of 1,2- 4 parts of hexylene glycol and pungent glycol.
The above-mentioned soluble preparation method for repairing scar micropin, includes the following steps：
S1：Prepare Scutellaria galerioulata L extract, Radix Malvae sylvestris extract, peppery mint extract, veronica officinalis extract, Europe alpine yarrow Careless extract, purslane extract, Radix Arnebiae extract, nutgall extractive, Myrrha extract, Borneolum Syntheticum extract, chamomile extraction Object, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe extract, yam extract and Duyun Maojian Tea is taken to carry Object is taken, it is spare；
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Radix Malvae sylvestris extract, peppery peppermint are weighed respectively Extract, veronica officinalis extract, common milfoil extract, Radix Arnebiae extract, nutgall extractive, do not have purslane extract Medicament extract, Borneolum Syntheticum extract, chamomile extract, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe carry Object, yam extract, Duyun Maojian Tea extract, carrot seed essential oil and Lavender are taken, adds in 380 parts of deionized water, is mixed Conjunction stirs evenly, and filters to take filtrate；
S3：Weigh citric acid, soluble collagen, decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- oneself Glycol, pungent glycol are added it in the filtrate described in step S2, are uniformly mixed, and less than 40 DEG C rotary evaporations remove moisture, Form the soluble active ingredient for repairing scar micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 16% mass concentration is made；
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer；
S6：The soluble active ingredient for repairing scar micropin in step S3 is added in step S5 containing surrounding layer It in mold, dries again, is demoulded after dry and repair scar micropin up to soluble.The solubility repairs the microneedle configuration of scar, Including needle point 1, articulamentum 2, the needle point 1 is arranged on the articulamentum 2, and 1 outer layer of needle point is provided with surrounding layer 3；Institute Needle point 1 is stated as cone or triangle, is highly 200 microns.Needle point 1 is connect by articulamentum 2 with external device 4.
Embodiment 4
The present embodiment provides a kind of soluble reparation scar micropins, and in parts by weight, the active ingredient includes：Lemon 1.2 parts of acid, 25 parts of soluble collagen, 6 parts of Scutellaria galerioulata L extract, 9 parts of Radix Malvae sylvestris extract, peppery 18 parts of mint extract, medicine With 4 parts of Veronica extract, 40 parts of common milfoil extract, 90 parts of purslane extract, 85 parts of Radix Arnebiae extract, Chinese gall extraction 60 parts of object, 85 parts of Myrrha extract, 16 parts of Borneolum Syntheticum extract, 15 parts of aloe extract, 4 parts of yam extract, chamomile extraction 15 parts of object, 2 parts of glycine betaine, 5.5 parts of Burdok root P.E, 1 part of mung bean powder extracts, 6 parts of Radix Codonopsis extract, carrot seed essential oil 8.2 parts, 7 parts of Lavender, 15 parts of Duyun Maojian Tea extract, 25 parts of decoyl salicylic acid, 0.8 part of sodium hydroxide, mandelic acid 55 parts, 2.5 parts of 1,2- 6 parts of hexylene glycol and pungent glycol.
The above-mentioned soluble preparation method for repairing scar micropin, includes the following steps：
S1：Prepare Scutellaria galerioulata L extract, Radix Malvae sylvestris extract, peppery mint extract, veronica officinalis extract, Europe alpine yarrow Careless extract, purslane extract, Radix Arnebiae extract, nutgall extractive, Myrrha extract, Borneolum Syntheticum extract, chamomile extraction Object, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe extract, yam extract and Duyun Maojian Tea is taken to carry Object is taken, it is spare；
S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Radix Malvae sylvestris extract, peppery peppermint are weighed respectively Extract, veronica officinalis extract, common milfoil extract, Radix Arnebiae extract, nutgall extractive, do not have purslane extract Medicament extract, Borneolum Syntheticum extract, chamomile extract, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe carry Object, yam extract, Duyun Maojian Tea extract, carrot seed essential oil and Lavender are taken, adds in 320 parts of deionized water, is mixed Conjunction stirs evenly, and filters to take filtrate；
S3：Weigh citric acid, soluble collagen, decoyl salicylic acid according to parts by weight, sodium hydroxide, mandelic acid, 1,2- oneself Glycol, pungent glycol are added it in the filtrate described in step S2, are uniformly mixed, and less than 40 DEG C rotary evaporations remove moisture, Form the soluble active ingredient for repairing scar micropin；
S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 20% mass concentration is made；
S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken Go out, rotate clockwise 90 ° of placements, rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, again in 1000rpm Lower horizontal centrifugal 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer；
S6：The soluble active ingredient for repairing scar micropin in step S3 is added in step S5 containing surrounding layer It in mold, dries again, is demoulded after dry and repair scar micropin up to soluble.The solubility repairs the microneedle configuration of scar, Including needle point 1, articulamentum 2, the needle point 1 is arranged on the articulamentum 2, and 1 outer layer of needle point is provided with surrounding layer 3；Institute Needle point 1 is stated as cone or triangle, is highly 400 microns.Needle point 1 is connect by articulamentum 2 with external device 4.
The application example of product of the present invention is illustratively introduced with the product prepared in embodiment 4 below.The present invention other Product in embodiment has similar effect.
For the present invention from numerous volunteers, it is 25-55 Sui to have selected age bracket, and face suffers from different degrees of scar 300 volunteers, scar include hyperplastic scar, keloid, superficial scars, atrophic scar, depressed scar, operation Scar etc., wherein male to female ratio respectively account for half and carry out contrast test.300 volunteers are randomly divided into three groups, A groups, B groups and C Group, men and women volunteer's number in every group is identical, and the number of each age group is essentially identical.Volunteer in A groups uses this hair The product prepared in bright embodiment 4 weekly using once, is smeared at scar, twice a day daily；Volunteer in B groups uses Scar of dispelling frost (it is commercially available, have effects that desalinate scar, unisex), it smears at scar daily, twice a day；Aspiration in C groups Person eats scar drug (commercially available) of dispelling.After tracking 6 months, result is as follows：
Following table is the product Piglet s colibacillosis result in the embodiment of the present invention 4：
Wherein, criterion of therapeutical effect is：Recovery from illness：Scar disappears；It is effective：Scar repairs more than 50%；Effectively：Scar repairs 10% More than；In vain：It is unchanged before and after treatment or more serious.
The product that can be seen that the offer of the embodiment of the present invention 4 from the experimental result in table 1 is substantially better than commercial product.With After track six months, in A groups, the product provided using the embodiment of the present invention 4 can effectively repair scar, and cure rate reaches 93%, the volunteer not cured is obviously improved, and it is longer to cure the time needed.In B groups, use is commercially available Scar frost of dispelling, the volunteer that scar is relatively light and time of occurrence is shorter can cure；And scar is serious, the will of time of occurrence length Hope person is substantially without apparent effect.
Soluble reparation scar micropin provided by the invention, reparation scar is with obvious effects, efficient, and can improve skin The metabolism of skin so that skin restores normal physiological function, fundamentally repairs scar.During tracking, this is used The volunteer of the product provided in inventive embodiments 4, the skin around entire scar, which all has, to improve significantly, skin compared with Preceding more smooth exquisiteness, more glossy, high resilience.
The present invention is further described with reference to Fig. 1.
Fig. 1 is the structure diagram of the soluble microneedle configuration for repairing scar, including needle point 1, articulamentum 2, the needle point 1 It is arranged on the articulamentum 2,1 outer layer of needle point is provided with surrounding layer 3.Further include substrate 4, the needle point 1, articulamentum 2, Substrate 4 is sequentially connected.The needle point 1 is cone or triangle.The height of the needle point 1 is 50 microns -500 microns.It is described Needle point is equally spaced, and the distance between needle point is 0.4 millimeter -0.8 millimeter.2 thickness of articulamentum is micro- for 400 micron -600 Rice.The base diameter of the needle point 1 is 100 microns -200 microns.
The material of surrounding layer 3 mainly uses hyaluronic acid in the present embodiment.Hyaluronic acid with its unique molecular structure and Physicochemical property shows a variety of important physiological functions in body, and such as lubricating joint adjusts the permeability of vascular wall, adjusts egg White matter, Water-Electrolyte diffusion and operating, promotion, acceleration of wound healing etc..Micropin, which is pierced into skin, forms pin hole, and surrounding layer can be with Pin hole is made faster to heal and drug absorption can be promoted.Other macromolecule materials may be used in the material of certain surrounding layer 3, such as The monomer-polymer or copolymer of vinyl pyrrolidone and its derivative, ethyl cellulose, hyaluronic acid, glucan, Soluplus (Polyvinylcaprolactame-polyvinyl acetate-polyethyleneglycol-graft copolymer), hydroxypropyl methylcellulose, methyl-prop Olefin(e) acid copolymer, quaternary amine methacrylic acid copolymer, polylactic acid, polyglycolic acid, peptides chondroitin, collagen, chitosan, One or more of amylopectin, polysaccharide polymer etc..
The material of articulamentum 2 is large hydrophilic molecular material, and the large hydrophilic molecular material is selected from carbomer, methylol One or more of sodium cellulosate, hydroxypropyl methyl cellulose, pectin, gelatin, alginic acid, poloxamer.Micropin is using When, articulamentum 2 touches the tissue fluid overflowed in the moisture and a small amount of skin of skin surface, and articulamentum 2 dissolves, and needle point 1 can be led It is dynamic to be detached with substrate 4, and stay in skin, and suitable tip height enables needle point 1 to be reached completely through skin epidermis Skin corium is simultaneously released medicine in the skin below cuticula.Needle point 1 can be detached with substrate 4 and be fallen completely substantially in 15 seconds It falling, after needle point 1 is fallen, substrate surface is slightly smooth, is returned to gel state after the material hydrophilic of articulamentum 2 again, and needle point 1 Root is trimly fallen, and the form of needle point 1 keeps complete, does not remain the incomplete needle point of form, thus illustrates complete needle point 1 Detach what is fallen rather than dissolve in water with substrate 4, the dissolution time of needle point 1 is much larger than the dissolution time of articulamentum 2.
After needle point 1 is detached with substrate 4, needle point is stayed in the body, solve traditional soluble micropin without flexible substrate with The fitting problem of skin and anaphylaxis injury, intradermal fracture and waste are secondary caused by avoiding patch type substrate micropin Injure equivalent risk；The features such as it is convenient to be prepared with production, fast quantification drug release, no secondary injury.
More than, it is merely preferred embodiments of the present invention, but the protection domain invented is not limited thereto, it is any ripe Know those skilled in the art in the technical scope disclosed by the present invention, the change or replacement that can be readily occurred in should all be contained Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be subject to the protection domain of claims.

Claims (10)

  1. Soluble repair scar micropin 1. a kind of, which is characterized in that including active ingredient, in parts by weight, it is described effectively into Divide and include：
    0.2-1.5 parts of citric acid, 10-33 parts of soluble collagen, 2-14 parts of Scutellaria galerioulata L extract, Radix Malvae sylvestris extract 5-18 Part, peppery mint extract 7-30 parts, 0.5-5 parts of veronica officinalis extract, 13-53 parts of common milfoil extract, purslane extraction 50-130 parts of object, 50-100 parts of Radix Arnebiae extract, 50-100 parts of nutgall extractive, 70-90 parts of Myrrha extract, borneol extraction 15-20 parts of object, 12-15 parts of aloe extract, 3-6 parts of yam extract, 12-15 parts of chamomile extract, 1-2 parts of glycine betaine, 3-6 parts of Burdok root P.E, 1-3 parts of mung bean powder extracts, Radix Codonopsis extract 4-8 parts, 8-9 parts of carrot seed essential oil, lavender essence It is 6-7 parts oily.
  2. 2. soluble reparation scar micropin according to claim 1, which is characterized in that in parts by weight, described effective Ingredient includes：0.5-1 parts of citric acid, 18-25 parts of soluble collagen, 5-10 parts of Scutellaria galerioulata L extract, Radix Malvae sylvestris extract 10- 15 parts, peppery mint extract 18-26 parts, 2-4 parts of veronica officinalis extract, 25-40 parts of common milfoil extract, purslane extraction 70-100 parts of object, 60-85 parts of Radix Arnebiae extract, 70-80 parts of nutgall extractive, 75-85 parts of Myrrha extract, Borneolum Syntheticum extract 16-18 parts, 13-14 parts of aloe extract, 4-5 parts of yam extract, 13-14 parts of chamomile extract, 1-2 parts of glycine betaine, ox 4-5 parts of burdock root extract, 1-3 parts of mung bean powder extracts, Radix Codonopsis extract 5-6 parts, 8-9 parts of carrot seed essential oil, Lavender 6-7 parts.
  3. 3. soluble reparation scar micropin according to claim 2, which is characterized in that in parts by weight, described effective Ingredient includes：0.8 part of citric acid, 20 parts of soluble collagen, 8 parts of Scutellaria galerioulata L extract, 12 parts of Radix Malvae sylvestris extract, peppery peppermint 22 parts of extract, 3 parts of veronica officinalis extract, 35 parts of common milfoil extract, 85 parts of purslane, 75 parts of Asian puccoon, Chinese gall 75 Part, 80 parts of myrrh, 17 parts of borneol, 13 parts of aloe, 4.5 parts of Chinese yam, 13.5 parts of chamomile extract, 1.5 parts of glycine betaine, radix bardanae 4.5 parts, 2 parts of mung bean flour, 5.5 parts of Radix Codonopsis, 8.5 parts of carrot seed essential oil, 6.5 parts of Lavender.
  4. 4. soluble reparation scar micropin according to any one of claim 1-3, which is characterized in that according to parts by weight Meter, further includes 8-22 parts of Duyun Maojian Tea extract.
  5. 5. soluble reparation scar micropin according to any one of claim 1-3, which is characterized in that further include decoyl water 7-30 parts of poplar acid, 0.2-1.8 parts of sodium hydroxide, 50-75 parts of mandelic acid, 1,2- 3-8 parts of hexylene glycol, pungent glycol 1-3 parts.
  6. 6. soluble reparation scar micropin according to any one of claim 1-3, which is characterized in that further include outsourcing Layer, the material for forming surrounding layer are selected from monomer-polymer or copolymer, the ethyl cellulose of vinyl pyrrolidone and its derivative Element, hyaluronic acid, glucan, soluplus, hydroxypropyl methylcellulose, methacrylic acid copolymer, quaternary amine methacrylic acid are total to Polymers, polylactic acid, polyglycolic acid, peptides chondroitin, collagen, chitosan, amylopectin, one kind in polysaccharide polymer or It is a variety of.
  7. 7. soluble reparation scar micropin according to claim 6, which is characterized in that the material for forming surrounding layer is transparent Matter acid, the mass concentration of the hyaluronic acid is 15%~20%.
  8. 8. a kind of soluble preparation method for repairing scar micropin described in claim 1, which is characterized in that including walking as follows Suddenly：
    S1：Prepare Scutellaria galerioulata L extract, Radix Malvae sylvestris extract, peppery mint extract, veronica officinalis extract, common milfoil carries Take object, purslane extract, Radix Arnebiae extract, nutgall extractive, Myrrha extract, Borneolum Syntheticum extract, chamomile extract, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe extract, yam extract and Duyun Maojian Tea extract, It is spare；
    S2：By weight, the Scutellaria galerioulata L extract of gained in step S1, Radix Malvae sylvestris extract, peppery peppermint extraction are weighed respectively Object, veronica officinalis extract, common milfoil extract, purslane extract, Radix Arnebiae extract, nutgall extractive, myrrh carry Take object, Borneolum Syntheticum extract, chamomile extract, Burdok root P.E, mung bean powder extracts, Radix Codonopsis extract, aloe extract, Yam extract, Duyun Maojian Tea extract, carrot seed essential oil and Lavender add in 300-400 parts of deionized water, mix Conjunction stirs evenly, and filters to take filtrate；
    S3：Citric acid, soluble collagen, decoyl salicylic acid are weighed according to parts by weight, sodium hydroxide, mandelic acid, 1,2- hexylene glycol, Pungent glycol is added it in the filtrate described in step S2, is uniformly mixed, and less than 40 DEG C rotary evaporations remove moisture, is formed Solubility repairs the active ingredient of scar micropin；
    S4：Hyaluronic acid is dissolved in distilled water, the hyaluronic acid solution of 15%-20% mass concentrations is made；
    S5：Hyaluronic acid solution is added in micropin mold, horizontal centrifugal 5 minutes under 1000rpm；Mold is taken out, it is suitable Hour hands are rotated by 90 ° placement, are rotated 2 minutes with 100rpm；Mold taking-up is rotated by 90 ° counterclockwise, it is horizontal under 1000rpm again Centrifugation 2 minutes；So it is repeated 2 times；Mold is taken out, is dried, completes the preparation of surrounding layer；
    S6：The soluble active ingredient for repairing scar micropin in step S3 is added to the mold containing surrounding layer in step S5 In, it dries again, is demoulded after dry and repair scar micropin up to soluble.
  9. A kind of 9. soluble microneedle configuration for repairing scar, which is characterized in that the soluble microneedle configuration packet for repairing scar Needle point (1), articulamentum (2) are included, the needle point (1) is arranged on the articulamentum (2), and needle point (1) outer layer is provided with outer Covering (3)；The needle point (1) is cone or triangle.
  10. 10. the soluble microneedle configuration for repairing scar according to claim 9, which is characterized in that the height of the needle point (1) Spend is 50-500 microns.
CN201810167837.3A 2018-02-28 2018-02-28 A kind of soluble reparation scar micropin and preparation method thereof Withdrawn CN108210434A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109846808A (en) * 2019-03-20 2019-06-07 广州纳丽生物科技有限公司 Crystallite injection liquid cosmetics, preparation method and skin makeup rifle with spot-removing function
CN109846785A (en) * 2019-03-20 2019-06-07 广州纳丽生物科技有限公司 A kind of solvable micropin and preparation method thereof with spot-removing function
CN110935097A (en) * 2019-12-03 2020-03-31 广州新济薇娜生物科技有限公司 Microneedle patch for improving skin hypertrophic scar and preparation method thereof
CN111558128A (en) * 2019-03-26 2020-08-21 华中科技大学同济医学院附属协和医院 A kind of soluble microneedle array carrying scar repairing drug and preparation method

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109846808A (en) * 2019-03-20 2019-06-07 广州纳丽生物科技有限公司 Crystallite injection liquid cosmetics, preparation method and skin makeup rifle with spot-removing function
CN109846785A (en) * 2019-03-20 2019-06-07 广州纳丽生物科技有限公司 A kind of solvable micropin and preparation method thereof with spot-removing function
CN111558128A (en) * 2019-03-26 2020-08-21 华中科技大学同济医学院附属协和医院 A kind of soluble microneedle array carrying scar repairing drug and preparation method
CN110935097A (en) * 2019-12-03 2020-03-31 广州新济薇娜生物科技有限公司 Microneedle patch for improving skin hypertrophic scar and preparation method thereof
CN110935097B (en) * 2019-12-03 2021-10-29 广州新济薇娜生物科技有限公司 Microneedle patch for improving skin hypertrophic scar and preparation method thereof

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