CN104825563B - A kind of Chinese medicine preparation treating cervical spondylosis and preparation method thereof - Google Patents

Abstract

The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating cervical spondylosis and preparation method thereof.The preparation of the present invention includes the weight proportion of following raw material of Chinese medicine and each raw material and is respectively as follows: Radix Astragali 10-40g, Radix Puerariae 10-40g, Rhizoma Corydalis 10-40g, Rhizoma Et Radix Notopterygii 10-40g, Radix Saposhnikoviae 10-40g, Herba Asari 3-6g, Radix Angelicae Dahuricae 10-40g, Agkistrodon 10-40g, Squama Manis 10-40g, Scorpio 10-40g, Scolopendra 10-40g, Radix Angelicae Sinensis 10-40g, Radix Paeoniae Alba 10-40g, Rhizoma Chuanxiong 10-40g, Radix Notoginseng 10-40g, Flos Carthami 10-40g, Radix Salviae Miltiorrhizae 10-40g, Cortex Eucommiae (parched) 10-40g, Rhizoma Drynariae 10-40g, Cornu Cervi Pantotrichum 10-40g, Carapax et Plastrum Testudinis 10-40g, Cortex Cinnamomi 10-40g, Radix Glycyrrhizae 10-40g.The preparation process of medicament of the present invention is: step 1, medicine oven drying at low temperature；Step 2, medicine mix after pulverizing and sieving；Step 3, to hybrid medicine sterilization, be packaged into bag.The invention have benefit that, fundamentally the recurrence for the treatment of cervical spondylosis and pre-preventing cervical spondylosis, has promoting blood circulation, dredging meridian and relieving pain concurrently, the merit of liver and kidney tonifying.

Description

A kind of Chinese medicine preparation treating cervical spondylosis and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating cervical spondylosis and preparation method thereof.

Background technology

Cervical intervertebral disk degenerative changes and secondary pathological change involves organizational structure (nerve root, spinal cord, vertebral artery, sympathetic nerve etc.) about, and occurs that corresponding clinical manifestation person is called cervical spondylosis.Cervical spondylosis is Orthopedic Clinical commonly encountered diseases, frequently-occurring disease.Patient's the lighter's neck and shoulder brachialgia, dizziness and headache, severe one hurt like hell or myasthenia of limbs, notably suddenly faint, and has had a strong impact on the healthy living of people.Western medicine diagnose pathological: 1, local type: pillow cervical pain, neck limitation of activity, cervical muscle is stiff, and head and neck is limited in certain position, cervical region both sides tenderness significance.X mating plate shows that cervical vertebrae physiological radian changes.2, spondylotic radiculopathy: neck-shoulder pain, occipitalia and rear cervical region are ached, and radiate to upper limb, and pain the lighter is distending pain, and severe one such as acupuncture is lancinated, and innervation district dermal sensation of getting involved is gone down, and cervical muscle is nervous, has significance pressure pain point, lead arm and the pressure head experiment positive.X line sheet shows that pathological interspinal gap is narrow or hypertrophy, and intervertebral foramina diminishes.Vegetation and nerve root canal is had to narrow after the visible vertebral body of MRI.3, myeloid form: be mainly in 40～60 years old, neck takes on not necessarily pain, can slightly feel uncomfortable, and the tiny action of hand is malfunctioning, instability of gait, may occur in which that pathologic reflex, severe one may occur in which difficulty in walking, incontinence of urination and defecation or urine retention.X line sheet shows that pathological interspinal dish is narrow, hyperosteogeny.MRI shows spinal canal narrows, the more serious and prominent people's canalis spinalis of vertebral body trailing edge hypertrophy.4, vertebral artery type: headache and dizzy, tinnitus dim eyesight, hypomnesis, occasionally there are face and eye symptom, damping off even head rotation causes dizziness may occur in which.The visible uncovertebral joint of x line oblique film is laterally projecting, vertebral arteriography display distortion or narrow.5, adrenergic type: having sympathetic activation or suppress symptom, X-ray film shows hook vertebra hypertrophy, and intervertebral foramina narrows, and cervical vertebrae physiological radian changes, and vertebral arteriography has pressurized phenomenon.6, mixed type: the two or more pressure symptom persons of existence.

For cervical spondylosis, there is multiple therapy at present.Physiotherapy has and utilizes the traction treatment of various machinery, massotherapy, thermotherapy, magnetic therapy etc., simply local treatment, and can not be adjusted on the whole, and effect is not ideal enough；And the medicine treating hyperosteogeny mostly is medicine for external use, generally can only relief of symptoms；Although also there being oral medicine, but toxicity is big, should not take for a long time.Operative therapy, wound is big, and dangerous high, patient is not easily accepted by；Western medicine therapy, mainly nonsteroidal anti-inflammatory analgesic, because side effect is big, patient is not also easily accepted by.So, in the urgent need to determined curative effect, toxic and side effects is little, is suitable for the medicine of long-term taking.

Summary of the invention

For the deficiencies in the prior art, the present invention provides Chinese medicine preparation for the treatment of cervical spondylosis that a kind of instant effect, cure rate are high, have no side effect and preparation method thereof.

The present invention provides a kind of Chinese medicine preparation treating cervical spondylosis, weight proportion including following raw material of Chinese medicine and each raw material is respectively as follows: Radix Astragali 10-40g, Radix Puerariae 10-40g, Rhizoma Corydalis 10-40g, Rhizoma Et Radix Notopterygii 10-40g, Radix Saposhnikoviae 10-40g, Herba Asari 3-6g, Radix Angelicae Dahuricae 10-40g, Agkistrodon 10-40g, Squama Manis 10-40g, Scorpio 10-40g, Scolopendra 10-40g, Radix Angelicae Sinensis 10-40g, Radix Paeoniae Alba 10-40g, Rhizoma Chuanxiong 10-40g, Radix Notoginseng 10-40g, Flos Carthami 10-40g, Radix Salviae Miltiorrhizae 10-40g, Cortex Eucommiae (parched) 10-40g, Rhizoma Drynariae 10-40g, Cornu Cervi Pantotrichum 10-40g, Carapax et Plastrum Testudinis 10-40g, Cortex Cinnamomi 10-40g, Radix Glycyrrhizae 10-40g.

Further, it is respectively as follows: Radix Astragali 20-40g, Radix Puerariae 20-40g, Rhizoma Corydalis 20-40g, Rhizoma Et Radix Notopterygii 20-40g, Radix Saposhnikoviae 20-40g, Herba Asari 3-5g, Radix Angelicae Dahuricae 20-40g, Agkistrodon 20-40g, Squama Manis 20-40g, Scorpio 20-40g, Scolopendra 20-40g, Radix Angelicae Sinensis 20-40g, Radix Paeoniae Alba 20-40g, Rhizoma Chuanxiong 20-40g, Radix Notoginseng 20-40g, Flos Carthami 20-40g, Radix Salviae Miltiorrhizae 20-40g, Cortex Eucommiae (parched) 20-40g, Rhizoma Drynariae 20-40g, Cornu Cervi Pantotrichum 20-40g, Carapax et Plastrum Testudinis 20-40g, Cortex Cinnamomi 20-40g, Radix Glycyrrhizae 20-40g including the weight proportion of following raw material of Chinese medicine and each raw material.

Further, it is respectively as follows: Radix Astragali 20-30g, Radix Puerariae 20-30g, Rhizoma Corydalis 20-30g, Rhizoma Et Radix Notopterygii 20-30g, Radix Saposhnikoviae 20-30g, Herba Asari 3-4g, Radix Angelicae Dahuricae 20-30g, Agkistrodon 20-30g, Squama Manis 20-30g, Scorpio 20-30g, Scolopendra 20-30g, Radix Angelicae Sinensis 20-30g, Radix Paeoniae Alba 20-30g, Rhizoma Chuanxiong 20-30g, Radix Notoginseng 20-30g, Flos Carthami 20-30g, Radix Salviae Miltiorrhizae 20-30g, Cortex Eucommiae (parched) 20-30g, Rhizoma Drynariae 20-30g, Cornu Cervi Pantotrichum 20-30g, Carapax et Plastrum Testudinis 20-30g, Cortex Cinnamomi 20-30g, Radix Glycyrrhizae 20-30g including the weight proportion of following raw material of Chinese medicine and each raw material.

Further, the parts by weight of described each raw material are preferably: Radix Astragali 20g, Radix Puerariae 20g, Rhizoma Corydalis 20g, Rhizoma Et Radix Notopterygii 20g, Radix Saposhnikoviae 20g, Herba Asari 3g, Radix Angelicae Dahuricae 20g, Agkistrodon 20g, Squama Manis 20g, Scorpio 20g, Scolopendra 20g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 20g, Rhizoma Chuanxiong 20g, Radix Notoginseng 20g, Flos Carthami 20g, Radix Salviae Miltiorrhizae 20g, Cortex Eucommiae (parched) 20g, Rhizoma Drynariae 20g, Cornu Cervi Pantotrichum 20g, Carapax et Plastrum Testudinis 20, Cortex Cinnamomi 20g, Radix Glycyrrhizae 20g.

The form of Chinese drug of the present invention makes any acceptable preparation clinically according to a conventional method, can be such as powder, pill, tablet, capsule, granule, patch or ointment.According to the needs of different preparations, the corresponding customary adjuvant of interpolation can be chosen.

The preparation method that the present invention also provides for a kind of Chinese medicine preparation treating cervical spondylosis, adopts the raw material of weight proportion provided by the invention, and preparation process is:

Step 1, by above-mentioned raw materials respectively oven drying at low temperature；

Step 2, step 1 is dried after raw material, be crushed to respectively with pulverizer can cross 300 mesh sieves, by all pulverize after raw material mix homogeneously；

Step 3, the raw material sterilization that will mix in step 2, average mark dresses up bag afterwards.Dose that the several evidence of bag of subpackage specifically adopts and different, be typically between 40-120 bag.

The administrated method of Chinese medicine preparation provided by the present invention, sooner or later respectively takes 1 bag after meal in every day, takes after mixing it with water with yellow wine, within 1 month, be 1 course for the treatment of, withdraw 7 days between each course for the treatment of, avoid peppery, cool during medication.

Cervical spondylosis is generally taken 1-2 the course for the treatment of and can be fully recovered, and the cervical spondylosis of especially severe is generally taken 3 courses for the treatment of and can fully recover.

The medicament of the present invention forms according to theory of Chinese medical science: kidney governing bones, liver governing tendons, in combination with long-term clinical practice preparation.Medical knowledge thinks caused by liver and kidney deficiency, insufficiency of vital energy and blood, and be affected by the cold damp simultaneously, causes that blockage of meridian is the basic pathogenesis that development occurs cervical spondylosis.The medicine composition of the present invention is what to complete on the basis to Etiology of Cervical Spondylosis pathogenesis heightened awareness:

In side Agkistrodon dispel the wind, dredging collateral, relieving convulsion；

Squama Manis invigorate blood circulation disappear, stimulate the menstrual flow, stimulating milk secretion, detumescence and apocenosis；

Scorpio, Scolopendra endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain；

Above four medicines share, and play the merit of blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain altogether, meet YE Tian shi and are said: pathogen usually intruding into collateral in protracted disease, must, by the reason of insect medicine dredging collateral promoting blood circulation and stopping pain, be monarch drug in side altogether.

Pseudo-ginseng blood-circulation-invigovating blood stasis dispelling and subduing swelling and relieving pain, for controlling the good merchantable brand of all cards of blood stasis, for the key medicine of traumatology, pharmacy man Li Shizhen (1518-1593 A.D.) claims Radix Notoginseng to be " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) "；

Flos Carthami, Radix Salviae Miltiorrhizae promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing；

Chinese angelica blood supplementing regulating menstruation, promoting blood circulation and stopping pain；

The Radix Paeoniae Alba is nourished blood yin fluid astringing, easing the affected liver to relieve pain, suppressing liver-YANG；

Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping；

Rhizoma Corydalis blood-activating and qi-promoting pain relieving,

Above seven medicines share the merit of the promoting blood circulation, dredging meridian and relieving pain to strengthen monarch drug, are ministerial drug altogether.

Radix Astragali invigorating the spleen and benefiting QI invigorating middle warmer, benefit defend consolidating superficial resistance；

Radix Puerariae expelling pathogenic factors from muscles is delivered, promoting the production of body fluid to quench thirst, is good at treatment neck pain；

Rhizoma Et Radix Notopterygii is induced sweat cold expelling, expelling wind and dampness, pain relieving, Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion；

Herba Asari induces sweat cold expelling, wind-expelling pain-stopping；

The Radix Angelicae Dahuricae induces sweat cold expelling, wind-expelling pain-stopping；

Above six medicines share, and play expelling pathogenic wind from the body surface cold expelling altogether and do not hinder the merit of table, for adjuvant drug in side.

Cortex Eucommiae (parched) invigorating the liver and kidney, bone and muscle strengthening；

Rhizoma Drynariae is invigorated blood circulation and is continued wound, the kidney invigorating bone strengthening；

Cornu Cervi Pantotrichum kidney-replenishing, benefiting essence-blood, bone and muscle strengthening；

Carapax et Plastrum Testudinis nourishing YIN for suppressing the hyperactive YANG, replenishing kidney and strengthening bone；

Cortex Cinnamomi mends fire supporing yang, dispersing cold for relieving pain, warming the meridian and promoting blood circulation；

Above five kinds of Chinese medicine phase 5, plays the effect of invigorating the liver and kidney, bone and muscle strengthening, dispelling cold by warming the meridian, altogether for adjuvant drug in side.

Radix Glycyrrhizae relieving spasm to stop pain, replenishing QI to invigorate the spleen, be adjuvant in side.

Modern pharmacological research shows:

The Radix Astragali can promote the renewal of organism metabolism, resisting fatigue, promotion serum and hepatic protein；Anemia animal phenomenon can be improved；Hypoglycemia can be raised, reduce hyperglycemia；Can excited breathe；Can strengthen and regulate body's immunity, interferon system being had facilitation, the premunition of body can be improved；The multiple viral institute such as infected by influenza cytopathogenic effect has slight inhibitory action, and influenza virus infected has protective effect；There is wide antibacterial action；The Radix Astragali, in cell is cultivated, can make cell showed increased, and Growth of Cells is vigorous, life；Myocardial contraction can be strengthened, protect cardiovascular system, arrhythmia, coronary artery dilator and peripheral blood vessel, reduce blood pressure, platelet adhesion power can be reduced, reduce thrombosis；Also have blood fat reducing, defying age, anti-hypoxia, radioprotective, protect the liver etc. acts on.

Pueraria lobata, alcohol preserved material, total flavones, daiazi, puerarin all can resist the acute myocardial ischemia that pituitrin causes；Radix Puerariae total flavones energy dilating coronary blood vessel and cerebrovascular, increase coronary flow and cerebral blood flow, reduces myocardial oxygen consumption, increases oxygen supply；Radix Puerariae can directly expand blood vessel, makes Peripheral resistance decline, and has obvious hypotensive effect, can better alleviate " item is tight " symptom of hypertensive patient；Puerarin can improve microcirculation, improves the micro-blood flow in local, it is suppressed that platelet aggregation.

Tetrahydropalmatine has significant analgesia, hypnosis, calm and stable effect, and the analgesic activity of A prime and Chou prime is also comparatively obvious, and has certain hypnosis, calm and stable effect；Ethanol extract energy coronary artery dilating, reduction coronary resistance, increase coronary flow, improve hypoxia-bearing capability；Total alkali to arrhythmia, can resist myocardial ischemia, and expands peripheral blood vessel, reduces blood pressure, decreased heart rate, and full alkali has antiulcer, suppresses the effect of stomachial secretion；B prime and Chou prime have the effect of relaxed muscle.

Rhizoma Et Radix Notopterygii injection has analgesia and refrigeration function, and dermatophytes, Brucella are had inhibitory action；Rhizoma Et Radix Notopterygii water portion has Antiarrhythmic Effect；Volatile oil also has antiinflammatory, analgesia, refrigeration function, and can resist myocardial ischemia and the increase cardiac muscle nutritional blood flow that pituitrin causes；Mice delayed hypersensitivity reaction there is inhibitory action.

Radix Saposhnikoviae has antipyretic, antiinflammatory, calmness, analgesia, convulsion, anti-allergic effects.Dysentery bacterium, Hemolytic streptococcus etc. are had inhibitory action in various degree by Radix Saposhnikoviae decoct；And have the effect strengthening Phagocytosis By The Peritoneal Macrophages In Mice.

Herba Asari volatile oil, water and alcohol extract are respectively provided with antipyretic, antiinflammatory, calmness, convulsion and local anesthetic action；Heavy dose of volatile oil suppresses after can making the excitement of central nervous system elder generation, shows certain toxic and side effects；China's kakuol preserved material can to the respiration inhibition caused by anti-morphine ab；Contained higenamine has heart tonifying, expansion blood vessel, relaxing smooth muscle, enhancing lipid metabolism and raises the effects such as blood glucose；Contained safrole toxicity is relatively strong, is carcinogen, high temperature destructible.

Angelicotoxin has stimulating central nervous system, raising blood pressure effect in a small amount, and sialorrhea can be caused to vomit；Tonic spasm can be caused in a large number, continue with general paralysis；The Radix Angelicae Dahuricae can to the central nervous system impression caused by venom；There are antipyretic, antiinflammatory, analgesia, spasmolytic, antitumaous effect.

Agkistrodon has calmness, hypnosis and analgesic activity；Injection has notable hypotensive effect；Water extract can activate fibrinolytic system；Ethanol extract can strengthen macrophages phagocytic capacity, dramatically increases Carbon clearance rate.

Squama Manis decocting liquid can be obviously prolonged mice and rat clotting time, reduces blood viscosity；Water extract-alcohol precipitation agent has directly expansion blood vessel wall to reduce Peripheral resistance, dramatically increases the effect of femoral artery blood flow；Aqueous extracts and alcohol extract have antiinflammatory action, and Aqueous extracts still has the effect of anti-myocardial ischemia, leukocyte increasing.

Scorpio, containing scorpion venom, is a kind of Neurotoxic protein of similar snake venom.Scorpion Venom of Buthus Martensii Karsch and the antiepilepsy peptide (AEP) that purification obtains from thick poison have obvious antiepileptic action；The convulsions that strychnine, nicotine, pentetrazole etc. are caused by Scorpio has antagonism；Scorpion extraction liquid has suppression animal thrombosis to be formed and anticoagulation；Animal body pain or Encelialgia are all had obvious analgesic activity by scorpion body and scorpion tail preparation；Scorpion tail analgesic activity is than scorpion stiffness of the body about 5 times.

The convulsions that strychnine is caused by Scolopendra Aqueous extracts has obvious antagonism；Scolopendra decoct can improve the microcirculation of mice, extends clotting time, reduces blood viscosity, and has obvious analgesia, antiinflammatory action.

Radix Angelicae Sinensis volatile oil can the excitation to uterus to antiadrenergic drug pituitrin or histamine；Radix Angelicae Sinensis water or alcohol-soluble nonvolatile confrontation isolated uterine have excitation, make uterine contraction strengthen, and during a large amount of or multiple dosing, even may occur in which tetanic contraction, and alcohol-soluble material effect is stronger than water-soluble substances effect.In vitro Venenum Bufonis cardiac perfusion is tested, and this product decoct can substantially suppress shrinkage amplitude and contraction frequency containing volatile oil；Eumenol has notable expansion isolated guinea pig coronary effect, increases coronary flow；Anesthetized dog intravenous this product, heart rate declines without obvious change, coronary resistance and total peripheral resistance, and coronary flow dramatically increases, and myocardial oxygen consumption is remarkably decreased, and heart output and SI have increase trend；Expeirmental myocardial ischemia is also had obvious protective function by Radix Angelicae Sinensis neutral oil；Radix Angelicae Sinensis and sodium ferulate thereof have obvious anti thrombotic action；To Mouse oral Radix Angelicae Sinensis infusion, hemoglobin and erythrocytic generation can be remarkably promoted.

Radix Paeoniae Alba water decoction bites percentage rate and phagocytic index all relatively matched group is significantly improved to mice feed abdominal cavity is huge；The Radix Paeoniae Alba can promote the phagocytic function of Turnover of Mouse Peritoneal Macrophages；Radix Paeoniae Alba water decoction can the antagonism cyclophosphamide inhibitory action to mice peripheral T lymphocyte, so as to recover normal level, it was shown that the Radix Paeoniae Alba can make to be in the cellular immune function of low state and recover normal；Rat Ovum Gallus domesticus album acute inflammation edema is had obvious inhibiting effect by Radix Paeoniae Alba extract, and granuloma induced by implantation of cotton pellets has Inhibiting proliferation effect；The writhing response that Radix Paeoniae Alba Dichlorodiphenyl Acetate causes has obvious analgesic effect, share with the methanol complex of Radix Glycyrrhizae, and the two Dichlorodiphenyl Acetate writhing response has synergic antalgic effect；Main component peoniflorin in Radix Paeoniae has good spasmolysis.

Ligustrazine energy coronary artery dilator, increases coronary artery blood flow, improves the blood oxygen supply of cardiac muscle, and reduces the oxygen consumption of cardiac muscle；The expansible cerebrovascular of ligustrazine, reduces vascular resistance, dramatically increases brain and LBF amount, improve microcirculation；Surface activity of blood platelet can be reduced, it is suppressed that platelet aggregation, the formation of pre-preventing thrombosis；Animal central nervous systems is had sedation by water decoction, and has obvious and lasting hypotensive effect；The absorption of fracture local hematoma can be accelerated, promote callus formation；There is vitamin antagonist E shortage effect；Multiple bacillus can be suppressed；There are antihistaminic and choleretic effect.

Radix Notoginseng can shorten hemorrhage and clotting time, has antiplatelet aggregation and thrombolytic effect；Humoral immune function can be improved, there is analgesia, antiinflammatory, the anti-ageing effect of waiting for a long time.

Flos Carthami decoct, Aqueous extracts, Carthamus yellow etc. can be expanded peripheral vessels, reduce blood pressure；Can suppress that blood is little pulls gathering, fortifying fibre protein dissolution, reduces whole blood viscosity；Injection, ethanol extract, saffloside can significantly improve hypoxia-bearing capability, and the weary oxygen encephalopathy of ischemia is had protective effect；There is excitation in uterus and intestinal smooth by decoct；Central nervous system is had analgesia, calmness and anticonvulsant action by Carthamus yellow；Additionally, Safflower extract and water extract have antiinflammatory action；Carthamus yellow has immunosuppressive action.

Radix Salviae Miltiorrhizae energy coronary artery dilating, increases coronary flow, improves myocardial ischemia, promotes the recovery of myocardial ischemia or damage, reduces myocardial infarct size；Hypoxia-bearing capability can be improved, hypoxic cardiac muscle is had protective effect；Microcirculation can be improved, promote velocity of blood flow；Blood vessel can be expanded, reduce blood pressure；Hemorheological property can be improved, reduce blood viscosity, it is suppressed that platelet and coagulation function, activate fibrinolytic, to antithrombus formation；Erythrocyte membrane can be protected；Blood fat can be regulated, it is suppressed that the formation of atheromatous plaque；Hepatocyte injury can be protected, promote liver cell regeneration, have effect of anti hepatic fibrosis；The healing of fracture and skin incision can be promoted；Gastric mucosa, anti-gastric-ulcer can be protected；Nervus centralis is had calmness and analgesic activity；There is the effect improving renal function, protection Ischemic kieney injury；There is antiinflammatory, antianaphylactic effect.

Cortex Eucommiae can suppress DNCB induced mice delayed hypersensitivity；To the immunosuppressive action of antioxidation cortisone, can have the function regulating cell immune balance.Rabbit and Canis familiaris L. are had obvious hypotensive effect by the water decoction of Cortex Eucommiae, Cortex Eucommiae (parched) and the stir-baking in sand Cortex Eucommiae, but Cortex Eucommiae hypotensive effect is more weak, and the effect of Cortex Eucommiae (parched) and the stir-baking in sand Cortex Eucommiae is nearly identical, and the absolute value of its blood pressure lowering is equivalent to the twice of Cortex Eucommiae.

Rhizoma Drynariae water decoction-alcohol sedimentation liquid has prophylactic serum cholesterol, triglyceride to raise, and prevents the effect that Aorta atheromatous plague formed；Rhizoma Drynariae polysaccharide and Rhizoma Drynariae flavanone glycosides have the effect of blood fat reducing and arteriosclerosis；Osteomiosis complementary energy promotes the bone absorption to calcium, improves blood calcium and serum phosphorus levels, is conducive to the healing of fracture；Improve chondrocyte, postpone the degeneration of osteocyte；Additionally, Rhizoma Drynariae flavanone glycosides has obvious calmness, analgesic activity.

Heavy dose of pantocrine makes heart contracting amplitude reduce, decreased heart rate, and makes peripheral blood vessel expand, and blood pressure reduces.Median dose pantocrine causes isolated heart activity to be remarkably reinforced, and heart contracting amplitude increases, and increased heart rate, result makes heart pulse output and percentage output all increase.Cornu Cervi Pantotrichum has obvious lipoid peroxidization resistant and anti-stress effect.

Carapax et Plastrum Testudinis can improve animal " deficiency of YIN " and demonstrate,prove pathology animal functional status, so as to recover normal；Immunologic function can be strengthened；There is the effect of two-ways regulation DNA synthetic ratio；In vitro and Uterus in vivo all there is excitation；Have antipyretic, enrich blood, sedation；Still there is anticoagulation, increase coronary flow and improve the effects such as hypoxia-bearing capability；Colla Plastri Testudinis has certain effect promoting leukocyte count.

Cortex Cinnamomi has expansion blood vessel, blood circulation promoting, enhancing arteria coronaria and cerebral blood flow, makes degradation effect under vascular resistance；In vitro, its methanolic extract and cinnamic aldehyde have anti-platelet aggregation, antithrombase effect；Oleum Cinnamomi, cinnamic aldehyde, Fortificar have the effects such as calmness, analgesia, antipyretic, convulsion；Oleum Cinnamomi can promote bowel movement, makes digestive secretion increase, and strengthens digestive function, gets rid of digestive tract pneumatosis, alleviates crampy gastrointestinal pain, and can cause metremia；Cortex Cinnamomi water extract, ether extract are formed with inhibitory action to zoopery gastric ulcer.

Radix Glycyrrhizae has antibacterial, antiviral, antiinflammatory, anti-allergic effects；Some poisonous substance is had the Detoxication of similar glucuronic acid；There is similar adrenocortical hormone sample effect；Also have diuresis, blood fat reducing, protect the liver etc. acts on.

The present invention compared with prior art has the beneficial effect that

1, promoting blood circulation, dredging meridian and relieving pain, has the merit of liver and kidney tonifying concurrently.

2, the medicine used by the present invention is divided into four groups, and one group is insect medicine: Agkistrodon, Squama Manis, Scorpio, Scolopendra, meets YE Tian shi and is said: pathogen usually intruding into collateral in protracted disease, must by the reason of insect medicine dredging collateral promoting blood circulation and stopping pain；One group is promoting blood flow and remove blood stasis drug: Radix Notoginseng, Flos Carthami, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Rhizoma Corydalis, it is possible to strengthen the dredging collateral promoting blood circulation and stopping pain effect of insect medicine；One group is expelling wind and cold diaphoretic medicine: Radix Puerariae, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Herba Asari, the Radix Angelicae Dahuricae, and Compatibility with Radix Astragali can reach expelling wind and cold and induce sweat and the effect of not hindering table；One group is the strong bone medicine of Kidney-invigorating and tendon-reinforcing: Cortex Eucommiae (parched), Rhizoma Drynariae, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Cortex Cinnamomi, it is possible to Kidney-invigorating and tendon-reinforcing is good for bone, the fundamentally recurrence for the treatment of cervical spondylosis and pre-preventing cervical spondylosis.The first three groups medicine medicine for taking stopgap measures, the 4th group of medicine medicine for effecting a permanent cure, all medicines share, and reach the purpose for the treatment of both the principal and secondary aspects of a disease.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is described in further detail,

Embodiment 1:

The Chinese medicinal components of the present embodiment is by the preparation of following weight ratio: Radix Astragali 20g, Radix Puerariae 20g, Rhizoma Corydalis 20g, Rhizoma Et Radix Notopterygii 20g, Radix Saposhnikoviae 20g, Herba Asari 3g, Radix Angelicae Dahuricae 20g, Agkistrodon 20g, Squama Manis 20g, Scorpio 20g, Scolopendra 20g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 20g, Rhizoma Chuanxiong 20g, Radix Notoginseng 20g, Flos Carthami 20g, Radix Salviae Miltiorrhizae 20g, Cortex Eucommiae (parched) 20g, Rhizoma Drynariae 20g, Cornu Cervi Pantotrichum 20g, Carapax et Plastrum Testudinis 20, Cortex Cinnamomi 20g, Radix Glycyrrhizae 20g.

The manufacture method of the medicine of this weight proportion is by the present embodiment: first by said medicine oven drying at low temperature, then above 13 taste medical materials, be crushed to pulverizer and can cross 300 mesh sieves, mix homogeneously, after sterilization, powder is divided into 60 bags.

The present embodiment form of Chinese drug makes any acceptable preparation clinically according to a conventional method, can be such as powder, pill, tablet, capsule, granule, patch or ointment.According to the needs of different preparations, the corresponding customary adjuvant of interpolation can be chosen.

The administrated method of the Chinese medicine preparation that the present embodiment provides, sooner or later respectively takes 1 bag after meal in every day, takes after mixing it with water with yellow wine, within 1 month, be 1 course for the treatment of, withdraw 7 days between each course for the treatment of, avoid peppery, cool during medication.Cervical spondylosis is generally taken 1-2 the course for the treatment of and can be fully recovered, and the cervical spondylosis of especially severe is generally taken 3 courses for the treatment of and can fully recover.

Embodiment 2:

The Chinese medicinal components of the present embodiment is by the preparation of following weight ratio: Radix Astragali 40g, Radix Puerariae 40g, Rhizoma Corydalis 40g, Rhizoma Et Radix Notopterygii 40g, Radix Saposhnikoviae 40g, Herba Asari 6g, Radix Angelicae Dahuricae 40g, Agkistrodon 40g, Squama Manis 40g, Scorpio 40g, Scolopendra 40g, Radix Angelicae Sinensis 40g, Radix Paeoniae Alba 40g, Rhizoma Chuanxiong 40g, Radix Notoginseng 40g, Flos Carthami 40g, Radix Salviae Miltiorrhizae 40g, Cortex Eucommiae (parched) 40g, Rhizoma Drynariae 40g, Cornu Cervi Pantotrichum 40g, Carapax et Plastrum Testudinis 40, Cortex Cinnamomi 40g, Radix Glycyrrhizae 40g.

The manufacture method of the medicine of this weight proportion is by the present embodiment: first by said medicine oven drying at low temperature, then above 13 taste medical materials, be crushed to pulverizer and can cross 300 mesh sieves, mix homogeneously, after sterilization, powder is divided into 120 bags.

Embodiment 3:

The Chinese medicinal components of the present embodiment is by the preparation of following weight ratio: Radix Astragali 10g, Radix Puerariae 10g, Rhizoma Corydalis 10g, Rhizoma Et Radix Notopterygii 10g, Radix Saposhnikoviae 10g, Herba Asari 3g, Radix Angelicae Dahuricae 10g, Agkistrodon 10g, Squama Manis 10g, Scorpio 10g, Scolopendra 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Alba 10g, Rhizoma Chuanxiong 10g, Radix Notoginseng 10g, Flos Carthami 10g, Radix Salviae Miltiorrhizae 10g, Cortex Eucommiae (parched) 10g, Rhizoma Drynariae 10g, Cornu Cervi Pantotrichum 10g, Carapax et Plastrum Testudinis 10, Cortex Cinnamomi 10g, Radix Glycyrrhizae 10g.

The manufacture method of the medicine of this weight proportion is by the present embodiment: first by said medicine oven drying at low temperature, then above 13 taste medical materials, be crushed to pulverizer and can cross 300 mesh sieves, mix homogeneously, after sterilization, powder is divided into 40 bags.

Embodiment 4:

The Chinese medicinal components of the present embodiment is by the preparation of following weight ratio: Radix Astragali 23g, Radix Puerariae 26g, Rhizoma Corydalis 27g, Rhizoma Et Radix Notopterygii 25g, Radix Saposhnikoviae 23g, Herba Asari 4g, Radix Angelicae Dahuricae 22g, Agkistrodon 26g, Squama Manis 25g, Scorpio 26g, Scolopendra 24g, Radix Angelicae Sinensis 28g, Radix Paeoniae Alba 25g, Rhizoma Chuanxiong 22g, Radix Notoginseng 30g, Flos Carthami 24g, Radix Salviae Miltiorrhizae 23g, Cortex Eucommiae (parched) 25g, Rhizoma Drynariae 22g, Cornu Cervi Pantotrichum 30g, Carapax et Plastrum Testudinis 24, Cortex Cinnamomi 30g, Radix Glycyrrhizae 25g.

The manufacture method of the medicine of this weight proportion is by the present embodiment: first by said medicine oven drying at low temperature, then above 13 taste medical materials, be crushed to pulverizer and can cross 300 mesh sieves, mix homogeneously, after sterilization, powder is divided into 80 bags.

Embodiment 5:

The Chinese medicinal components of the present embodiment is by the preparation of following weight ratio: Radix Astragali 37g, Radix Puerariae 36g, Rhizoma Corydalis 33g, Rhizoma Et Radix Notopterygii 35g, Radix Saposhnikoviae 30g, Herba Asari 5g, Radix Angelicae Dahuricae 32g, Agkistrodon 36g, Squama Manis 35g, Scorpio 35g, Scolopendra 36g, Radix Angelicae Sinensis 36g, Radix Paeoniae Alba 35g, Rhizoma Chuanxiong 32g, Radix Notoginseng 38g, Flos Carthami 36g, Radix Salviae Miltiorrhizae 32g, Cortex Eucommiae (parched) 30g, Rhizoma Drynariae 32g, Cornu Cervi Pantotrichum 38g, Carapax et Plastrum Testudinis 33, Cortex Cinnamomi 37g, Radix Glycyrrhizae 36g.

The manufacture method of the medicine of this weight proportion is by the present embodiment: first by said medicine oven drying at low temperature, then above 13 taste medical materials, be crushed to pulverizer and can cross 300 mesh sieves, mix homogeneously, after sterilization, powder is divided into 100 bags.

The form of Chinese drug of embodiment 2-5 and the interpolation of adjuvant are all identical with embodiment 1.

The administrated method of the Chinese medicine preparation that embodiment 2-5 provides is all identical with embodiment 1.

In above example, in inventive formulation, Herba Asari, Agkistrodon, Scorpio, Scolopendra are all poisonous product.But due to the collaborative of drug matching and antagonism, its toxicity can be made to reduce.

Embodiment provided by the invention is carried out respectively animal toxicity test and clinical practice, find in animal toxicity test Chinese medicine avirulence, each embodiment proportioning all plays good therapeutic effect clinically, only the treatment utilizing embodiment 1 proportioning is described in detail below:

(1) animal toxicity test

1, acute toxicity test, adopts mouth medication

(1) take medicine 12g of the present invention to add water to grind and make full dose become the suspension (concentration is 300mg/ml) of 40ml standby.

(2) Kunming mouse 20 (each 10 of male and female) is taken, body weight (20 ± 2) g, every mice gives sample suspension 40ml/kg gavage (being equivalent to 60 times of people's consumption), once a day, observing 10 days, all healthy existence of mice, without any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding compares zero difference with matched group.Medicine of the present invention to the dosis tolerata of Mouse oral at more than 12g/kg.

(3) Kunming mouse 20 (each 10 of male and female) is taken, body weight (20 ± 2) g, every mice is grouped (often group 10) respectively and gives sample suspension 60ml/kg and 80ml/kg gavage (being respectively equivalent to 90 times of people's consumption, 120 times), once a day, observing 10 days, all healthy existence of two groups of mices of result, without toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding compares zero difference with matched group.The maximum tolerated dose of mice is at more than 24g/kg by visible medicine of the present invention.

2, accumulation toxicity test, adopts mouth medication

(1) take medicine 6g of the present invention to add water to grind and make full dose become the suspension (concentration is 150mg/ml) of 40ml standby.

(2) Kunming mouse 40 (each 20 of male and female) is taken, body weight (20 ± 2) g, every mice gives sample suspension 40ml/kg gavage (being equivalent to 30 times of people's consumption), once a day, observing three months, all healthy existence of mice, without any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding compares zero difference with matched group.Internal substantially without accumulation.

Show through acute toxicity test: the maximum tolerated dose of mice is at more than 24g/kg by this medicine；The accumulation toxicity test of mice is shown: the oral dose of 4g/kg, without accumulation, is 0.20g/kg higher than clinic adult's intended use.Patient is safe by this medicine.

(2) clinical practice

1, clinical criteria

All of patient all makes a definite diagnosis through X-ray photograph or CT examination, and makes a definite diagnosis in conjunction with patients symptomatic's analysis.

2, clinical data

600 examples are out-patient, all cases all meet cervical spondylosis in " practical combination of Chinese and Western medicine diagnoses and treatment " criterion (Chen Guiyan, Yang Sipeng. practicality combination of Chinese and Western medicine diagnoses and treatment).Patient is randomly divided into 2 groups, treatment group 300 example, male 180 examples, female 120 example；Minimum 25 years old of age, maximum 65 years old, the course of disease 3 months～10 years.Matched group 300 example, male 190 examples, female 110 example；Minimum 24 years old of age, maximum 66 years old, the course of disease 4 months～10 years；Two groups of patient's equal not statistically significants of difference (P > 0.05) in sex, age, the course of disease etc., have comparability.

3, Therapeutic Method

Treatment group gives drug oral of the present invention, and every day respectively takes a bag sooner or later after meal, takes after mixing it with water with yellow wine.Matched group gives JINGFUKANG KELI and is administered orally, one time 2 bags, 2 times on the one, sooner or later warm water delivery service after meal.2 groups equal 1 month is 1 course for the treatment of, observes curative effect after 2 courses for the treatment of.

4, efficacy assessment standard

With reference to People's Republic of China's traditional Chinese medical science industry standard " disease of tcm Standardization of diagnosis and curative effect ".

Curing: original various disease disappears, muscular strength is normal, and neck, limb functional recover are normal, can participate in normal work and work；

Taking a turn for the better: original various disease alleviates, muscular strength is normal, and neck, shoulder and back ache alleviate, and neck, limb function are improved；

Do not heal: symptom is not improved.

5, therapeutic outcome

Group	n	Cure	Effectively	Invalid	Total effective rate %
						Treatment group	300	260*	30	10	96.67*
Matched group	300	40	90	200	43.33

In table, * represents through χ²Inspection treatment group P < 0.01 compared with matched group.

As can be seen from the above table, the curative effect of medicine of the present invention is substantially better than JINGFUKANG KELI.

6, to the discussion of above technical scheme it can be seen that pharmic function of the present invention is promoting blood circulation, dredging meridian and relieving pain, have the merit of liver and kidney tonifying concurrently.Medicine used by the present invention is divided into four groups, and one group is insect medicine: Agkistrodon, Squama Manis, Scorpio, Scolopendra, meets YE Tian shi and is said: pathogen usually intruding into collateral in protracted disease, must by the reason of insect medicine dredging collateral promoting blood circulation and stopping pain；One group is promoting blood flow and remove blood stasis drug: Radix Notoginseng, Flos Carthami, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Rhizoma Corydalis, it is possible to strengthen the dredging collateral promoting blood circulation and stopping pain effect of insect medicine；One group is expelling wind and cold diaphoretic medicine: Radix Puerariae, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Herba Asari, the Radix Angelicae Dahuricae, and Compatibility with Radix Astragali can reach expelling wind and cold and induce sweat and the effect of not hindering table；One group is the strong bone medicine of Kidney-invigorating and tendon-reinforcing: Cortex Eucommiae (parched), Rhizoma Drynariae, Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Cortex Cinnamomi, it is possible to Kidney-invigorating and tendon-reinforcing is good for bone, the fundamentally recurrence for the treatment of cervical spondylosis and pre-preventing cervical spondylosis.The first three groups medicine medicine for taking stopgap measures, the 4th group of medicine medicine for effecting a permanent cure, all medicines share, and reach the purpose for the treatment of both the principal and secondary aspects of a disease, have significant curative effect.And there is the features such as treatment cost is low, curative effect is fast, patient suffering is little, there is good popularizing application prospect.

7, model case:

Example 1 Cai, man, 28 years old, people from LaiShan District, Yintai City, Shandong Province.Symptom is: extremity flaccidity is soft unable, can't take care of oneself more than 1 year, is diagnosed as C4～C7 through hospital's CT examination and saves hypertrophy, and pressuring nerve institute is extremely.On August 26th, 2006 examines, and fully recovers after Drug therapy of the present invention, 2 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 2 clock, man, 42 years old, people from Jinan City, Shandong Province.Suffering from cervical spondylosis 2 years, cervical region is ached, and right hand numbness is unable, dizziness headache.Chuckle during twisting neck and make a sound.On April 6th, 2002 examines, and fully recovers after Drug therapy of the present invention, 2 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 3 grandson, female, 40 years old, people from LaiShan District, Yintai City, Shandong Province.Cervical region is ached, dizziness headache, blurred vision.It is diagnosed as C3～C7 through hospital's CT examination and saves hypertrophy, spinal canal stenosis, cerebral blood supply insufficiency.On March 5th, 2004 examines, and fully recovers after Drug therapy of the present invention, 3 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 4 Zhao, female, 38 years old, people from Zhifu District, Yantai City.Neck, shoulder, backache, both hands torpor and swelling 7 wheat harvesting period, once took a large amount of Western medicine invalid.The proximal segment time, the pain increased, becoming severe at night, uneasy in either sitting or lying, restriction of neck motion.Left neck is stiff, and during cervical region activity, pain increases the weight of, and 4-7 cervical vertebra tenderness is obvious, pressure measurement by compression of neck (+), brachial plexus nerve distraction test (+).X-ray film shows: C4, C7 vertebral body hyperosteogeny, and bilateral uncovertebral joint gap is not wide.August 9 calendar year 2001 examines, and fully recovers after Drug therapy of the present invention, 2 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 5 Cao, man, 56 years old, Shandong Province Qufu City Dong Zhuan village people.Patient's neck, shoulder, occipitalia pain is more than 3 years, dizzy 1 year of headache.Proximal segment time aggravation, rigidity of the neck, change one's position ineffective, blurring of vision, often there is positional vertigo, through western medicines in treatment poor effect.Within 2002, JIUYUE is examined on the 12nd, checks diagnosis: 3～7 cervical spine tenderness are obvious, pressure measurement by compression of neck (+), brachial plexus nerve distraction test (+).X-ray shows that cervical curvature straightens, and C4, C5, C6 anterior margin of vertebral body is lips and teeth sample hypertrophy, C5～C6 stenosis of disc space.After Drug therapy of the present invention, 2 courses for the treatment of, all symptoms all eliminate, and neck and limb function activity full recovery are normal.Follow up a case by regular visits to and do not recur so far.

Example 6 Yuan, man, 48 years old, people from Accessories during Binzhou, Shandong Province.Suffer from cervical spondylosis 2 years, treat 3 months in institute of traditional Chinese medicine of Yantai City, without being clearly better.On October 9th, 2004 examines, and fully recovers after Drug therapy of the present invention, 2 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 7 Wang, female, 43 years old, Shandong Province Qufu City Dong Zhuan village people.Persistence nape pain companion's paroxysmal increases the weight of 1 year, once accepted multiple treatment and has no positive effect.On July 9th, 2005 examines, and haves a medical check-up and sees neck stiffness, and during cervical region activity, pain increases the weight of and activity is substantially limited, the spinous process position of C4～C7 all have in various degree by tenderness.Fully recover after Drug therapy of the present invention, 2 courses for the treatment of.Taking the photograph again the change of cervical part of esophagus X-ray film comparison iconography, cervical part of esophagus physiologic radian slightly rear convex deformation before treatment, after treatment, physiologic radian recovers normal.Follow up a case by regular visits to and do not recur so far.

Example 8 hole, man, 40 years old, Shandong Province Qufu City Dong Zhuan village people.Suffering from cervical spondylosis more than 2 years, shoulder is ached, dizziness, and have a stiff neck pain, double; two upper limb numbness pain.Once did the treatments such as neck brace traction, massage, but symptom had no and substantially alleviates.On June 7th, 2008 examines, and fully recovers after Drug therapy of the present invention, 2 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 9 river, man, 58 years old, people from Zhifu District, Yantai City.Patient's neck, shoulder and back ache, headache, dizziness, neck board is hard, upper limb numbness, has had a strong impact on work and life.Hospital's x-ray takes the photograph sheet, is diagnosed as: cervical spondylosis.Once having taken various kinds of drug, and still do not felt any better, the state of an illness constantly increases the weight of.On April 7th, 2010 examines, and fully recovers after Drug therapy of the present invention, 3 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 10 Zhang, man, 29 years old, people from LaiShan District, Yintai City, Shandong Province.Patient CT diagnosis for spinal canal stenosis, neck distending pain unbearably, upper limb numbness pain, dizzy, head can not twist, it is impossible to works, ill 2 years, draw through neck brace, massage, the therapeutic effect such as take medicine inconspicuous.On June 9th, 2011 examines, and fully recovers after Drug therapy of the present invention, 3 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 11 Shen, man, 49 years old, people from LaiShan District, Yintai City, Shandong Province.Patient's neck-shoulder pain 2 days, postemphasis can not turn to head or askew to side, and musculi colli is nervous, has obvious tenderness, and on X-ray film, visible cervical vertebra curve disappears and straightens.Within 2012, JIUYUE is examined on the 11st, fully recovers after Drug therapy of the present invention, 1 course for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 12 Lee, female, 50 years old, people from LaiShan District, Yintai City, Shandong Province.Long-term cervical region is ached, and with symptoms such as headache, dizziness, insomnia, Nausea and vomiting, examines as vertebral artery type of cervical spondylosis before 2 years.Multi-treatment is invalid.On November 9th, 2010 examines, and fully recovers after Drug therapy of the present invention, 2 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 13 Zhao, man, 62 years old, people from Zhifu District, Yantai City.Because triking dizziness, neck deadlock pain, precordial fullness pain are hospitalized for treatment, and film making checks that diagnosis is for cervical spinal stenosis, joint, cartilage, ligament, muscle damage.Main cause is for bending over one's desk working for a long time and caused by head, neck be once heavily hit.On March 11st, 2011 examines, and fully recovers after Drug therapy of the present invention, 3 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 14 Wang, female, 57 years old, Shandong Province Qufu City Wang Zhuan village people.Patient's neck, shoulder and back ache, restriction of neck motion, suffering limb feel obstacle, muscular strength weaken, amyotrophy, brachial plexus distraction test (+), pressure measurement by compression of neck (+), diagnose as cervical spondylotic radiculopathy, the course of disease 3 years, draw through neck brace, massage, the therapeutic effect such as take medicine inconspicuous.Within 2012, JIUYUE is examined on the 8th, fully recovers after Drug therapy of the present invention, 2 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 15 Zhao, female, 36 years old, Shandong Province Qufu City Dong Zhuan village people.Bilateral weakness of the lower extremities, numb, gradually instability of gait, difficulty in walking, limb hypermyotonia, tendon hyperreflexia, also have the symptom of headache, dizziness simultaneously, diagnose the Mixed Cervical Spondylosis into myeloid form and sympathetic type, the course of disease 2 years.On February 28th, 2010 examines, and fully recovers after Drug therapy of the present invention, 3 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 16 Korea Spro, man, 44 years old, people from LaiShan District, Yintai City, Shandong Province.Morbidity February, neck pain, occasionally there is a spinning sensation, dynamic then aggravate, double; two upper limb numbness discomfort, pressure measurement by compression of neck (+).Look into X-ray to show: C4-5, C5-6, C6-7 intervertebral disk hernia.Diagnosis is " cervical spondylosis ".On October 6th, 2009 examines, and fully recovers after Drug therapy of the present invention, 2 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 17 Lee, female, 46 years old, people from Accessories during Binzhou, Shandong Province.Falling ill 10 years, neck and left shoulder pain, tired postemphasis, rest can be alleviated, left upper extremity pain, and in companion's left hand, articulations digitorum manus and remote articulations digitorum manus are numb, and Hoffmann sign bilateral is positive.Look into MRI to show: C5-6 intervertebral disc is left back prominent.Looking into X-ray to show: cervical curvature shoals, bilateral part intervertebral foramina has hyperosteogeny slightly to protrude into.Diagnosis is " cervical spondylosis ".On June 7th, 2008 examines, and fully recovers after Drug therapy of the present invention, 2 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 18 Dong, man, 42 years old, people from From Shijiazhuang City of Hebei Province.Fall ill 13 years, neck deadlock pain, occasionally there is dizziness, numb limbs and tense tendons is unable, tired aggravation, alleviates after rest, pressure measurement by compression of neck (+), cervical spine tenderness.Looking into X-ray to show: cervical curvature straightens, left part intervertebral foramina has hyperosteogeny slightly to highlight.Diagnosis is " cervical spondylosis ".Within 2009, JIUYUE is examined on the 16th, fully recovers after Drug therapy of the present invention, 3 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 19 Zheng, man, 61 years old, Hangzhou, Zhejiang province people from city.Suffer from cervical spondylotic radiculopathy 2 years, the spinous process position of C3～C7 all have in various degree by tenderness, after when stretching cervicodynia increase the weight of, having neck sound during neck rotation, have pain during right and left shoulders joint motion, finger tip is numb sometimes, pressure measurement by compression of neck (+), brachial plexus nerve distraction test (+).On July 18th, 2009 examines, and fully recovers after Drug therapy of the present invention, 1 course for the treatment of.Follow up a case by regular visits to and do not recur so far.

Example 20 Zhang, man, 45 years old, Shandong Province Qufu City people.Suffering from cervical spondylopathy, cervicodynia is radiated to shoulder, upper limb numbness, unable, activity postemphasis, and integrative therapy more than 2 years is without positive effect.On March 18th, 2006 examines, and fully recovers after Drug therapy of the present invention, 2 courses for the treatment of.Follow up a case by regular visits to and do not recur so far.

It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when without departing substantially from the spirit of the present invention or basic feature, it is possible to realize the present invention in other specific forms.Therefore, no matter from which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the invention rather than described above limits, it is intended that all changes in the implication of the equivalency dropping on claim and scope included in the present invention.

In addition, it is to be understood that, although this specification is been described by according to embodiment, but not each embodiment comprises an independent technical scheme, this narrating mode of description is only for clarity sake, description should be made as a whole by those skilled in the art, and the technical scheme in each embodiment through appropriately combined, can also form other embodiments that it will be appreciated by those skilled in the art that.

Claims (7)

1. the Chinese medicine preparation treating cervical spondylosis, it is characterized in that, it is made up of following raw material of Chinese medicine, and the weight proportion of each raw material of Chinese medicine is respectively as follows: Radix Astragali 10-40g, Radix Puerariae 10-40g, Rhizoma Corydalis 10-40g, Rhizoma Et Radix Notopterygii 10-40g, Radix Saposhnikoviae 10-40g, Herba Asari 3-6g, Radix Angelicae Dahuricae 10-40g, Agkistrodon 10-40g, Squama Manis 10-40g, Scorpio 10-40g, Scolopendra 10-40g, Radix Angelicae Sinensis 10-40g, Radix Paeoniae Alba 10-40g, Rhizoma Chuanxiong 10-40g, Radix Notoginseng 10-40g, Flos Carthami 10-40g, Radix Salviae Miltiorrhizae 10-40g, Cortex Eucommiae (parched) 10-40g, Rhizoma Drynariae 10-40g, Cornu Cervi Pantotrichum 10-40g, Carapax et Plastrum Testudinis 10-40g, Cortex Cinnamomi 10-40g, Radix Glycyrrhizae 10-40g.

null2. a kind of Chinese medicine preparation treating cervical spondylosis according to claim 1，It is characterized in that，It is made up of following raw material of Chinese medicine，And the weight proportion of each raw material of Chinese medicine is respectively as follows: Radix Astragali 20-40g、Radix Puerariae 20-40g、Rhizoma Corydalis 20-40g、Rhizoma Et Radix Notopterygii 20-40g、Radix Saposhnikoviae 20-40g、Herba Asari 3-5g、Radix Angelicae Dahuricae 20-40g、Agkistrodon 20-40g、Squama Manis 20-40g、Scorpio 20-40g、Scolopendra 20-40g、Radix Angelicae Sinensis 20-40g、Radix Paeoniae Alba 20-40g、Rhizoma Chuanxiong 20-40g、Radix Notoginseng 20-40g、Flos Carthami 20-40g、Radix Salviae Miltiorrhizae 20-40g、Cortex Eucommiae (parched) 20-40g、Rhizoma Drynariae 20-40g、Cornu Cervi Pantotrichum 20-40g、Carapax et Plastrum Testudinis 20-40g、Cortex Cinnamomi 20-40g、Radix Glycyrrhizae 20-40g.

null3. a kind of Chinese medicine preparation treating cervical spondylosis according to claim 1，It is characterized in that，It is made up of following raw material of Chinese medicine，And the weight proportion of each raw material of Chinese medicine is respectively as follows: Radix Astragali 20-30g、Radix Puerariae 20-30g、Rhizoma Corydalis 20-30g、Rhizoma Et Radix Notopterygii 20-30g、Radix Saposhnikoviae 20-30g、Herba Asari 3-4g、Radix Angelicae Dahuricae 20-30g、Agkistrodon 20-30g、Squama Manis 20-30g、Scorpio 20-30g、Scolopendra 20-30g、Radix Angelicae Sinensis 20-30g、Radix Paeoniae Alba 20-30g、Rhizoma Chuanxiong 20-30g、Radix Notoginseng 20-30g、Flos Carthami 20-30g、Radix Salviae Miltiorrhizae 20-30g、Cortex Eucommiae (parched) 20-30g、Rhizoma Drynariae 20-30g、Cornu Cervi Pantotrichum 20-30g、Carapax et Plastrum Testudinis 20-30g、Cortex Cinnamomi 20-30g、Radix Glycyrrhizae 20-30g.

4. a kind of Chinese medicine preparation treating cervical spondylosis according to any one of claim 1-3, it is characterized in that, it is made up of following raw material of Chinese medicine, and the weight proportion of each raw material of Chinese medicine is respectively as follows: Radix Astragali 20g, Radix Puerariae 20g, Rhizoma Corydalis 20g, Rhizoma Et Radix Notopterygii 20g, Radix Saposhnikoviae 20g, Herba Asari 3g, Radix Angelicae Dahuricae 20g, Agkistrodon 20g, Squama Manis 20g, Scorpio 20g, Scolopendra 20g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 20g, Rhizoma Chuanxiong 20g, Radix Notoginseng 20g, Flos Carthami 20g, Radix Salviae Miltiorrhizae 20g, Cortex Eucommiae (parched) 20g, Rhizoma Drynariae 20g, Cornu Cervi Pantotrichum 20g, Carapax et Plastrum Testudinis 20, Cortex Cinnamomi 20g, Radix Glycyrrhizae 20g.

5. a kind of Chinese medicine preparation treating cervical spondylosis according to claim 4, it is characterised in that: the dosage form that described Chinese medicine adopts is pharmaceutically acceptable dosage form.

6. a kind of Chinese medicine preparation treating cervical spondylosis according to claim 5, it is characterised in that: the dosage form that described Chinese medicine adopts is powder, pill, tablet, capsule, granule, patch or ointment.

7. the preparation method of the Chinese medicine preparation of a treatment cervical spondylosis as claimed in claim 1, it is characterised in that concrete preparation process is:

Step 1, by the raw material oven drying at low temperature described in claim 1；

Step 2, step 1 is dried after raw material, be crushed to respectively with pulverizer can cross 300 mesh sieves, by all pulverize after raw material mix homogeneously；

Step 3, the raw material sterilization that will mix in step 2, average mark dresses up bag afterwards.