CN101278965A - Soft capsule of humifuse spurge and preparing method thereof - Google Patents
Soft capsule of humifuse spurge and preparing method thereof Download PDFInfo
- Publication number
- CN101278965A CN101278965A CNA2008101126798A CN200810112679A CN101278965A CN 101278965 A CN101278965 A CN 101278965A CN A2008101126798 A CNA2008101126798 A CN A2008101126798A CN 200810112679 A CN200810112679 A CN 200810112679A CN 101278965 A CN101278965 A CN 101278965A
- Authority
- CN
- China
- Prior art keywords
- soft capsule
- humifuse
- spurge
- herba euphorbiae
- euphorbiae humifusae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to a humifuse euphorbia extract humifuse euphorbia soft capsule and processes for preparing the soft capsule. The humifuse euphorbia soft capsule consists of total flavonoid extract, antioxidant, encapsulation stabilizer and diluent. The humifuse euphorbia soft capsule has good appearance and stability. Compared with the existing humifuse euphorbia preparation, the humifuse euphorbia soft capsule has the characteristics of more homogeneous content and higher bioavailability and absorption rate, etc.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of Herba Euphorbiae Humifusae extract soft capsule and preparation method thereof.
Background technology
Herba Euphorbiae Humifusae is the ground herb of Euphorbiaceae euphorbia Herba Euphorbiae Humifusae (Euphorbia himifusa Willd.), has another name called Herba Chenopodii Hybridi, red shank grass, Herba euphorbiae prostratae, milk grass etc., is born in wasteland, open country, roadside, field, and aboundresources is distributed more widely.Herba Euphorbiae Humifusae belongs to antipyretic and antidotal type Chinese medicine, effect with heat-clearing and toxic substances removing, promoting blood circulation and hemostasis, dampness removing lactogenesis, be usually used in treatment and let out dysentery, too fat to move furuncle, hemorrhage, jaundice due to damp-heat and galactostasis etc., be widely used in clinically, its water decoction, tincture have better curative effect to bacillary dysentery, enteritis etc.Its composition mainly contains flavonoid and tannin class, and the tannin composition is more in its middle period.Existing Herba Euphorbiae Humifusae preparation is conventional capsule and tablet, but used extract is a Herba Euphorbiae Humifusae ethanol crude extract in the existing dosage form, and composition is assorted, and dosage is big, and ordinary preparation drug release rate is slow in vivo, easy disintegrating absorbs.
Summary of the invention
The object of the invention is to provide a kind of taking convenience, absorbs fast, that bioavailability is high Herba Euphorbiae Humifusae extract oral soft capsule preparation and preparation technology thereof.
Herba Euphorbiae Humifusae extract of the present invention prepares through degree of depth purification, general flavone content height in the extract, and effective ingredient is comparatively clear and definite, and dose is few.
The present invention improves absorption and the bioavailability of human body to the Herba Euphorbiae Humifusae total flavones to shorten in vivo disintegration time of tablet, to improve its dissolution and start with.Solution of the present invention is high-load Herba Euphorbiae Humifusae extract micronization, is mixed with a kind of stablizing, and the solid-liquid suspendible system of homogeneous is made soft capsule again.This product have content accurately, characteristics such as good dispersion, bioavailability and absorbance height.
Herba Euphorbiae Humifusae extract of the present invention can prepare in the following way:
Herba Euphorbiae Humifusae medical material 1000g, the alcohol reflux with 60% three times filters, merge each time extracting solution, be evaporated to into the extractum shape, NaOH aqueous solution dissolving extractum with 5%, filter, get the NaOH clear liquid, the hydrochloric acid with 10% transfers pH to about 3, leave standstill, filter, precipitation is washed till water lotion with distilled water and becomes neutral, the dissolve with ethanol of insoluble matter reuse 10% disperses, with polyamide adsorption resin column on the dispersion liquid, resin is earlier with 10% ethanol elution, and is thin out to the eluent color, use 65% ethanol elution instead, thin out to the eluent color, essentially no flavone reaction, the ethanol elution part of collection 65%, merge, concentrating under reduced pressure, drying promptly gets Herba Euphorbiae Humifusae extract.
In the soft capsule of humifuse spurge of the present invention, contain the Herba Euphorbiae Humifusae extract for preparing as above-mentioned mode, antioxidant, capsulation stabilizer, diluent.
Above-mentioned antioxidant is one or more in tea polyphenols, tertiarybutylhydroquinone, propyl gallate, the dibenzylatiooluene, is preferably propyl gallate;
Above-mentioned capsulation stabilizer is one or more in Cera Flava, Adeps caprae seu ovis, soybean phospholipid, methylcellulose, ethyl cellulose, Polyethylene Glycol monostearate, tween 80, Macrogol 4000, the polyethylene glycol 6000, is preferably tween 80;
Above-mentioned diluent is one or more in Semen Maydis oil, soybean oil, safflower oil, Oleum Arachidis hypogaeae semen, perilla oil, Oleum sesami, Oleum Helianthi, the walnut oil, is preferably soybean oil.
Particularly, in the soft capsule of humifuse spurge prescription of the present invention, each ingredient is by weight percentage: 10%～50% Herba Euphorbiae Humifusae extract, 0.1～1% propyl gallate, 3%～20% tween 80,28%～87% soybean oil.
Preferably, in the present invention prescription, each ingredient by weight percentage, 15%～25% Herba Euphorbiae Humifusae extract, 0.1～0.15% propyl gallate, 10%～20% tween 80,55%～75% soybean oil.
The technology of preparation soft capsule of the present invention can realize in the following way:
(1) get the Herba Euphorbiae Humifusae medical material, the alcohol reflux with 60% three times filters, merge each time extracting solution, be evaporated to into the extractum shape, NaOH aqueous solution dissolving extractum with 10%, filter, get the NaOH clear liquid, the hydrochloric acid with 15% transfers pH to about 3.5, leave standstill, filter, precipitation is washed till water lotion with distilled water and becomes neutral, the dissolve with ethanol of insoluble matter reuse 5% disperses, with polyamide adsorption resin column on the dispersion liquid, resin is earlier with 5% ethanol elution, and is thin out to the eluent color, use 45% ethanol elution instead, thin out to the eluent color, essentially no flavone reaction, the ethanol elution part of collection 45%, merge, concentrating under reduced pressure, drying gets extract.
(2) Herba Euphorbiae Humifusae extract is pulverized, crossed 200 purposes sieve, standby.
(3) get the part soybean oil, present in an amount at least sufficient to fully moistening all medicated powder, add propyl gallate and tween 80, mix thoroughly, medicated powder is poured in this mixture, the limit edged stirs, up to complete mixing.And then the soybean oil of adding surplus, the limit edged stirs, up to complete mixing, and the degassing, standby.
(4) above-mentioned substance is made soft capsule with the soft capsule packer, clean, dry, promptly.
For showing progressive of the present invention, we have done the disintegration time and the dissolution experiment of soft capsule of the present invention, and contrast with the Herba Euphorbiae Humifusae tablet.Dissolution determination method adopts an appendix XIIA of Chinese Pharmacopoeia version in 2005 inspection technique disintegration, and experimental result sees Table 1 and table 2
Table 1 soft capsule of humifuse spurge and ordinary tablet disintegration time are relatively
Table 2 soft capsule of humifuse spurge and conventional tablet dissolution are relatively
As can be seen from Table 1, the disintegration time of soft capsule has improved 2～3 times than conventional tablet.
As can be seen from Table 2, the dissolution of soft capsule is about 20 times of ordinary tablet in 5 minutes.
Specific embodiment
The invention will be further described with embodiment below, provides implementation detail of the present invention, but be not intended to limit protection scope of the present invention.
Embodiment 1
Herba Euphorbiae Humifusae extract (obtaining) 60g according to the description method
Propyl gallate 0.3g
Tween 80 40g
Soybean oil 200g
Preparation technology:
Herba Euphorbiae Humifusae extract is pulverized, crossed 200 purposes sieve, standby.
Get the part soybean oil, present in an amount at least sufficient to fully moistening all Herba Euphorbiae Humifusae extract medicated powder, add propyl gallate and tween 80, mix thoroughly, medicated powder is poured in this mixture, the limit edged stirs, up to complete mixing.
And then the soybean oil of adding surplus, the limit edged stirs, up to complete mixing, and the degassing, standby.
Above-mentioned substance is made soft capsule with the soft capsule packer, clean, dry, be pressed into 1000 soft capsule of humifuse spurge, the mensuration disintegration time is 10`30``, dissolution was 80.6% in 5 minutes.
Following examples provide the soft capsule prescription to be formed, and preparation technology is with embodiment 1
Embodiment 2
Prescription (1000 recipe quantities)
Herba Euphorbiae Humifusae extract 75g
Propyl gallate 0.4g
Tween 80 35g
Soybean oil 190g
The mensuration disintegration time is 11`27``, and dissolution was 79.9% in 5 minutes.
Embodiment 3
Prescription (1000 recipe quantities)
Herba Euphorbiae Humifusae extract 45g
Propyl gallate 0.45g
Tween 80 45g
Soybean oil 210g
The mensuration disintegration time is 12`47``, and dissolution was 80.1% in 5 minutes.
Embodiment 4
Prescription (1000 recipe quantities)
Herba Euphorbiae Humifusae extract 150g
Propyl gallate 0.45g
Tween 80 30g
Soybean oil 120g
The mensuration disintegration time is 13`54``, and dissolution was 78.7% in 5 minutes.
Claims (10)
1, a kind of soft capsule of humifuse spurge comprises capsule core material and softgel shell, it is characterized in that capsule core material contains 10%～50% Herba Euphorbiae Humifusae extract by weight percentage, 0.1%～1% antioxidant, 3%～20% capsulation stabilizer and the diluent of surplus.
2, soft capsule of humifuse spurge as claimed in claim 1 is characterized in that the proportioning of each component, by weight percentage, contain 15%～25% Herba Euphorbiae Humifusae extract, 0.1～0.15% antioxidant, 10%～20% capsulation stabilizer, 55%～75% diluent.
3, soft capsule of humifuse spurge as claimed in claim 1 or 2 is characterized in that described Herba Euphorbiae Humifusae extract is a Herba Euphorbiae Humifusae flavones ingredient extract.
4, soft capsule of humifuse spurge as claimed in claim 1 or 2 is characterized in that described antioxidant is one or more in tea polyphenols, tertiarybutylhydroquinone, propyl gallate, the dibenzylatiooluene.
5, antioxidant as claimed in claim 4 is characterized in that antioxidant is preferably propyl gallate.
6, as claimed in claim 1 or 2, it is characterized in that described capsulation stabilizer is one or more in Cera Flava, Adeps caprae seu ovis, soybean phospholipid, methylcellulose, ethyl cellulose, Polyethylene Glycol monostearate, tween 80, Macrogol 4000, the polyethylene glycol 6000.
7, capsulation stabilizer as claimed in claim 6 is characterized in that capsulation stabilizer is preferably tween 80.
8, soft capsule of humifuse spurge as claimed in claim 1 or 2 is characterized in that described diluent is one or more in Semen Maydis oil, soybean oil, safflower oil, Oleum Arachidis hypogaeae semen, perilla oil, Oleum sesami, Oleum Helianthi, the walnut oil.
9, as right 8 described diluent, it is characterized in that diluent is preferably soybean oil.
10, a kind of method for preparing soft capsule of humifuse spurge as claimed in claim 1 or 2 is characterized in that following processing step:
(1) get the Herba Euphorbiae Humifusae medical material, the alcohol reflux with 60% three times filters, merge each time extracting solution, be evaporated to into the extractum shape, NaOH aqueous solution dissolving extractum with 10%, filter, get the NaOH clear liquid, the hydrochloric acid with 15% transfers pH to about 3.5, leave standstill, filter, precipitation is washed till water lotion with distilled water and becomes neutral, the dissolve with ethanol of insoluble matter reuse 5% disperses, with polyamide adsorption resin column on the dispersion liquid, resin is earlier with 5% ethanol elution, and is thin out to the eluent color, use 45% ethanol elution instead, thin out to the eluent color, essentially no flavone reaction, the ethanol elution part of collection 45%, merge, concentrating under reduced pressure, drying gets extract.
(2) Herba Euphorbiae Humifusae extract is pulverized, crossed 200 purposes sieve, standby.
(3) get the part diluent, present in an amount at least sufficient to fully moistening all medicated powder, add antioxidant and capsulation stabilizer, mix thoroughly, medicated powder is poured in this mixture, the limit edged stirs, up to complete mixing.And then the diluent of adding surplus, the limit edged stirs, up to complete mixing, and the degassing, standby.
(4) above-mentioned substance is made soft capsule with the soft capsule packer, clean, dry, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101126798A CN101278965A (en) | 2008-05-26 | 2008-05-26 | Soft capsule of humifuse spurge and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101126798A CN101278965A (en) | 2008-05-26 | 2008-05-26 | Soft capsule of humifuse spurge and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101278965A true CN101278965A (en) | 2008-10-08 |
Family
ID=40011752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101126798A Pending CN101278965A (en) | 2008-05-26 | 2008-05-26 | Soft capsule of humifuse spurge and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101278965A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302538A (en) * | 2011-09-01 | 2012-01-04 | 山东华尔康兽药有限公司 | Humifuse euphorbia herb extract, preparation process and application thereof |
| CN103142685A (en) * | 2013-02-07 | 2013-06-12 | 浙江中医药大学 | Method for extraction of total flavonoid aglycones from hickory leaves |
| CN104255988A (en) * | 2014-08-29 | 2015-01-07 | 广西大学 | Tea type capsules and production method thereof |
| CN105476020A (en) * | 2015-11-30 | 2016-04-13 | 广州市富诺生物科技有限公司 | Vitamin D3 soft capsule and preparation method thereof |
| CN107536848A (en) * | 2017-08-31 | 2018-01-05 | 新疆奇康哈博维医药研究院（有限公司） | Herba Euphorbiae Humifusae extract is preparing the application of Induces Autophagy medicine |
-
2008
- 2008-05-26 CN CNA2008101126798A patent/CN101278965A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302538A (en) * | 2011-09-01 | 2012-01-04 | 山东华尔康兽药有限公司 | Humifuse euphorbia herb extract, preparation process and application thereof |
| CN103142685A (en) * | 2013-02-07 | 2013-06-12 | 浙江中医药大学 | Method for extraction of total flavonoid aglycones from hickory leaves |
| CN104255988A (en) * | 2014-08-29 | 2015-01-07 | 广西大学 | Tea type capsules and production method thereof |
| CN105476020A (en) * | 2015-11-30 | 2016-04-13 | 广州市富诺生物科技有限公司 | Vitamin D3 soft capsule and preparation method thereof |
| CN105476020B (en) * | 2015-11-30 | 2018-05-15 | 广州富诺健康科技股份有限公司 | A kind of vitamin D3Soft capsule and preparation method thereof |
| CN107536848A (en) * | 2017-08-31 | 2018-01-05 | 新疆奇康哈博维医药研究院（有限公司） | Herba Euphorbiae Humifusae extract is preparing the application of Induces Autophagy medicine |
| CN107536848B (en) * | 2017-08-31 | 2020-08-04 | 新疆奇沐医药研究院（有限公司） | Application of humifuse euphorbia herb extract in preparation of cell autophagy induction medicine |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104383123A (en) | Method for preparing golden camellia lipid-lowering blood sugar-reducing preparation | |
| KR20150096798A (en) | Pharmaceutical composition for treating headache, and preparation method thereof | |
| CN103385903A (en) | Stevia rebaudiana phenol extract and application thereof in preparing lipid-lowering products | |
| CN101278965A (en) | Soft capsule of humifuse spurge and preparing method thereof | |
| CN102614281A (en) | Chinese medicinal composition for improving anoxia endurance and preparation method and application thereof | |
| CN102085344B (en) | Aplotaxis carminative sustained-release preparation and preparation method thereof | |
| CN101849950A (en) | Application of rotundic acid in preparing blood lipid regulating medicines | |
| CN103211957B (en) | Alcohol relieving and liver protecting composition and application thereof | |
| CN100534524C (en) | Compound Chinese medicine Anxuekang and preparation method thereof | |
| CN100512796C (en) | Medicinal composition containing scutellaria glucoside and bupleurum and its preparation method | |
| CN1857385B (en) | Medicine composition for treating cervical spondylosis and its preparing method | |
| CN100420471C (en) | Oral taking preparation of Chinese traditional medicine for nourishing the kidney and the lung | |
| CN100542548C (en) | A kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof | |
| CN101579396A (en) | Euphorbia humifusa dispersing tablet and preparation process thereof | |
| CN104474040A (en) | Medicine composition for preventing and treating migraine disease, as well as preparation method and application thereof | |
| CN100453073C (en) | Compound radical lobelia dripping pill and its preparing method | |
| CN1321632C (en) | Compound saussurea involucrata capsule and its preparation process | |
| CN103705571B (en) | A kind of hemostatic analgesia capsule and preparation method thereof | |
| CN102430029B (en) | A kind of nano microcapsule for six ingredients with rehmannia and preparation technology thereof | |
| CN101167796B (en) | Monascus and red sage root composition for preventing and treating cardiovascular and cerebrovascular diseases | |
| CN108743800A (en) | A kind of traditional Chinese medicine powder for treating cardiovascular and cerebrovascular | |
| CN103285110B (en) | Traditional Chinese medicine for treating hyperlipidemia and preparation method thereof | |
| CN102526387A (en) | Medicinal composition for treating early-stage diabetic foot and preparation method thereof | |
| CN101850037B (en) | Medicinal composition for adjuvant therapy hepatitis | |
| CN105816473B (en) | A kind of flavonoid glycoside composition and its preparation and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20081008 |