CN105476020B - A kind of vitamin D3Soft capsule and preparation method thereof - Google Patents
A kind of vitamin D3Soft capsule and preparation method thereof Download PDFInfo
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- CN105476020B CN105476020B CN201510859340.4A CN201510859340A CN105476020B CN 105476020 B CN105476020 B CN 105476020B CN 201510859340 A CN201510859340 A CN 201510859340A CN 105476020 B CN105476020 B CN 105476020B
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- seed oil
- oil
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention belongs to field of health care food, more particularly to a kind of vitamin D3Soft capsule and preparation method thereof.The vitamin D3Soft capsule includes content and softgel shell, and the content includes the component of following parts by weight：Vitamin D3, vitamin D2, walnut oil, eucommia ulmoides seed oil, granada seed oil, amino acid, calcium citrate, antioxidant and stabilizer；The softgel shell includes the component of following parts by weight：Gelatin, glycerine, titanium dioxide and purified water.Vitamin D provided by the invention3Soft capsule contains multivitamin and vegetable oil, promote the absorption of calcium phosphorus while supplementing enough vitamin Ds for human body, and multiple nutritional components can be provided for human body, with enhancing cerebral function, enhancing immune function of human body, promote brain and nervous system development, interior free yl is removed, prevents a variety of chronic diseases generations and other effects.
Description
Technical field
The invention belongs to field of health care food, more particularly to a kind of vitamin D3Soft capsule and preparation method thereof.
Background technology
Vitamin D3Be it is a kind of to the mankind and growth of animal, development, breed, sustain life and ensure that health is indispensable
Liposoluble vitamin.Its main function is to adjust Ca,P metabolism, promotes calcium, the absorption of phosphorus and sclerotin calcification in field, maintains blood calcium
With the balance of serium inorganic phosphorus.Vitamin D3Shortage can cause the diseases such as rickets, osteomalacia, osteoporosis, the decline of thyroid gland technical ability.2001
The popular sex investigation for the vitamin D deficiency that Nian Duxue celerys carry out Chinese 1248 12 ~ 14 years old Pubertal girls in Beijing area
It has been shown that, the people for having 45.2% in sunshine weaker winter are in vitamin D clinic deficiency state.The synthesis dimension life of another aspect skin
The ability of plain D precursors is gradually reduced with the stingy of age, reduces outdoor activity because mobility is limited plus the elderly,
It may infer that the shortage of vitamin D is generally deposited in healthy elderly.It can be seen from the above that vitamin d insufficiency is still common existing
Problem.
Chinese patent application 201010032463.8 provides a kind of dimension D calcium soft capsules and preparation method thereof, including：Carbonic acid
Calcium powder, vitamine D3, soybean salad oil, soybean lecithin, beeswax, dimension D calcium soft capsules can supplement a certain amount of vitamin D3
And calcium, but the vitamin D of dimension D calcium soft capsules3Content is few, and stability is poor, easy photodissociation, and its nutritional ingredient is more single.
Therefore, it is necessary to provide it is a kind of have good stability, be not oxidizable, nutritional ingredient diversification vitamin D3Flexible glue
Capsule.
The content of the invention
In order to compensate for the shortcomings of the prior art, the present invention provides a kind of nutritional ingredient diversification, is supplemented for human body enough
Promote the absorption of calcium phosphorus, the vitamin D while vitamin D3Soft capsule is with good stability, not oxidizable and photodissociation.
Inventor adjusts the amount and species of each component, it is polynary finally to have invented a nutritional ingredient by the verification repeatedly of clinical practice
The vitamin D of change3Soft capsule.
To achieve these goals, technical scheme is as follows：
A kind of vitamin D3Soft capsule, including content and softgel shell, the content include the group of following parts by weight
Point：Vitamin D3 10 ~ 30 parts, vitamin D2 1 ~ 6 part, 3 ~ 10 parts of walnut oil, 2 ~ 6 parts of eucommia ulmoides seed oil, 2 ~ 6 parts of granada seed oil,
0.2 ~ 3 part of 6 ~ 15 parts of amino acid, 0.5 ~ 3 part of calcium citrate, 3 ~ 6 parts of antioxidant and stabilizer；The softgel shell includes following heavy
Measure the component of number：10 ~ 20 parts of 25 ~ 50 parts of gelatin, 15 ~ 20 parts of glycerine, 2 ~ 3 parts of titanium dioxide and purified water.
Preferably, the content includes the component of following parts by weight：Vitamin D3 10 parts, vitamin D2 1 part, core
1 part of 3 parts of peach oil, 2 parts of eucommia ulmoides seed oil, 2 parts of granada seed oil, 6 parts of amino acid, 1 part of calcium citrate, 3 parts of antioxidant and stabilizer.
Preferably, the content includes the component of following parts by weight：Vitamin D3 20 parts, vitamin D2 4 parts, core
6 parts of peach oil, 4 parts of eucommia ulmoides seed oil, 4 parts of granada seed oil, 9 parts of amino acid, 2 parts of calcium citrate, 4.5 parts of antioxidant and stabilizer 2
Part.
Preferably, the content includes the component of following parts by weight：Vitamin D3 30 parts, vitamin D2 6 parts, core
10 parts of peach oil, 6 parts of eucommia ulmoides seed oil, 6 parts of granada seed oil, 2 parts of amino acid/11,3 parts of calcium citrate, 6 parts of antioxidant and stabilizer 3
Part.
Preferably, the antioxidant presses 2 ~ 4 by vitamin C and vitamin E：1 ~ 2 weight ratio composition.
Preferably, the stabilizer is selected from beeswax, suet and soybean lecithin.
Preferably, the amino acid is at least one of lysine, threonine, glutamic acid and isoleucine.
Preferably, the softgel shell further includes 0.1 ~ 1 part of 1 ~ 3 part of iron oxide and preservative.
Correspondingly, present invention also offers the vitamin D3The preparation method of soft capsule, it comprises the following steps：
S1：Purified water and glycerine are weighed respectively in being mixed evenly in stainless-steel pan, add the gelatin, temperature control
Stirring is depressurized at 30 ~ 40 DEG C, 50 ~ 80 DEG C are warming up to after gelatin expansion, stirring is completely dissolved above-mentioned gelatin particle；
The titanium dioxide is added, decompression stirring is allowed to dissolve completely uniformly, and filtering, 50 ~ 60 DEG C of insulations of filtrate are stood, up to softgel shell glue
Liquid, it is stand-by；
S2：The stabilizer, antioxidant, vitamin D are weighed respectively3And vitamin D2, it is mixed evenly；Add institute
Walnut oil, eucommia ulmoides seed oil, granada seed oil, amino acid and calcium citrate are stated, is stirred evenly, crosses colloid mill homogeneous 3 ~ 5 times, often
Secondary 15 ~ 30min of homogeneous, that is, be made the suspension of appearance uniform, and suspension is placed in 60 ~ 100min of stirring in material-compound tank, that is, is made
Obtain the content；
S3：Temperature is controlled at 20 ~ 25 DEG C, by above-mentioned softgel shell glue and content automatic rotary transformation of ownership ball mechanism ball, softgel shell
Thickness control is 0.8 ~ 1.0mm, and capsule and pill surface oil stain is washed away with ethanol, when drying 10 ~ 20 is small at 30 ~ 35 DEG C, is packed to obtain the final product
The vitamine D3 soft capsule.
Preferably, preservative and iron oxide are added in the S1 steps.
Heretofore described vitamin D3Absorption of the human body to calcium, phosphorus can be improved, reaches plasma calcium and the level of blood plasma phosphorus
To degree of saturation, promote growth and bone calcification, promote tooth to perfect；Increase the absorption of phosphorus by intestinal wall, and pass through renal tubule
Increase the absorption of phosphorus；Maintain the normal level of citrate in blood：Prevent amino acid from being lost by kidney.For rickets,
The prevention of malacosteon and infantile tetany.
For the walnut oil rich in up to 90% or so a variety of unsaturated acids, wherein linoleic acid content is more, is common vegetable seed
3 to 4 times of oil content, especially be adapted to pregnant woman, infant, student, white collar and with brain overwork crowd eat, by numerous people
Scholar is known as " melatonin " in food.
Unsaturated fatty acid content is 91.18% in the eucommia ulmoides seed oil, and aliphatic acid composition is leukotrienes 67.38%, sub- oil
Acid 9.97%, oleic acid 15.81%, stearic acid 2.15%.Palmitic acid 4.68%, leukotrienes are mainly deposited in the form of DHA and EPA in vivo
.With lowering blood pressure and blood fat, memory and vision are improved, promotes infant brain development, the work(such as antiallergy, anticancer, antitumor
Can, all there is positive effect to enhancing memory function, analgesia, antifatigue, anti-aging, antitumor, adjusting immune function etc., especially
It is the bidirectional modulation immune function of uniqueness to safeguarding that it is vital that the health of human body plays the role of.
The granada seed oil is the how unsaturated conjugated fatty acid of unique plant source, its main component is punicic acid, content
Up to 70-80%.Because of the structure and conjugated linoleic acid of punicic acid（CLA）It is closest and be referred to as " super conjugated linoleic acid ",
Its feature exceedes conjugated linoleic acid in general sense.Granada seed oil is also rich in Antioxidative Factors, has very strong removing people
Body free radical and the ability to slow down aging, granada seed oil can protect human immune system, and prevention of arterial atherosis, reduces cancer
Become, help human body resistance cancer, obesity, diabetes and heart disease, there is very strong removing human free radical and anti-aging
Ability, while also contain the similar plant female hormone of female hormone structure produced to human body natural in granada seed oil, have
Help alleviate women's climacteric syndrome.
The calcium citrate is compared with calcium carbonate, and hydrochloric acid in gastric juice activated absorption is not required in calcium citrate, and absorptivity is good, in vivo not
It can cause gaseous distention as calcium carbonate produces carbon dioxide, it is harmless to alimentary canal mucous membrane, while calcium citrate is occasionally stronger to calcium
Complexing, during the concentration increase of calcium citrate in vivo, it can combine free calcium ion, and replace such as oxalic acid
Calcium in calcium, calcium phosphate, forms stable complex compound soluble easily in water, from internal discharge, it is suppressed that calcium salt（Calcium oxalate etc.）By
The lithogenous process of crystal shape is separated out in over-saturation state.
Compared with prior art, the present invention has following technical advantage：
1st, vitamin D provided by the invention3Soft capsule contains multivitamin and various plants oil, is tieed up being supplemented for human body
Promote the absorption of calcium phosphorus while raw element D, and multiple nutritional components can be provided for human body, there is enhancing cerebral function, enhancing people
Body immunity function, promotes brain and nervous system development, removes interior free yl, prevents a variety of chronic diseases generations and other effects.
2nd, vitamin D provided by the invention3Soft capsule can also play whitening, moisturizing, crease-resistant work as the outer used time
With.
3rd, vitamin D provided by the invention3Stability of Soft Capsules is good, has the advantages that to be not easy photodissociation, not oxidizable.
4th, vitamin D of the present invention3Soft capsule preparation process is simple, easy to industrial mass production.
Embodiment
It will be understood by those skilled in the art that technology disclosed in following embodiments represent the inventors discovered that in this hair
The technology of good action is played in bright practice.However, many changes can be made in disclosed specific embodiment, and
Still obtain the same or similar as a result, without departing from the spirit and scope of the present invention.
Vitamin D described in the embodiment of the present invention3The information such as the producer of constituent part and article No. is as follows in soft capsule：
Embodiment 1：Vitamin D3Soft capsule.
The vitamin D of the embodiment of the present invention 13Soft capsule includes content and softgel shell, and the content includes following heavy
Measure the component of number：Vitamin D310 parts, vitamin D21 part, 3 parts of walnut oil, 2 parts of eucommia ulmoides seed oil, 2 parts of granada seed oil, amino acid
1 part of 6 parts, 1 part of calcium citrate, 3 parts of antioxidant and stabilizer；The softgel shell includes the component of following parts by weight：Gelatin 25
Part, 15 parts of glycerine, 2 parts of titanium dioxide and 10 parts of purified water.
Wherein, the antioxidant is made of 1 part of 2 parts of vitamin C and vitamin E, and the stabilizer is by beeswax 0.2
0.5 part of part, 0.3 part of suet and soybean lecithin composition.
Preparation method：
S1：Purified water and glycerine is taken to add gelatin, temperature control subtracts at 30 DEG C in being mixed evenly in stainless-steel pan
Pressure stirring, is warming up to 60 DEG C, stirring is completely dissolved gelatin particle after gelatin expansion；Titanium dioxide is added, decompression is stirred
Mix and be allowed to dissolve completely uniformly, filtering, 50 DEG C of insulations of filtrate are stood, stand-by up to softgel shell glue；
S2：Take beeswax, suet, soybean lecithin, vitamin C, vitamin E, vitamin D3And vitamin D2, it is mixed equal
It is even；The walnut oil, eucommia ulmoides seed oil, granada seed oil, amino acid and calcium citrate are added, is stirred evenly, crosses colloid mill homogeneous 3
Secondary, each homogeneous 20min, that is, be made the suspension of appearance uniform, suspension be placed in material-compound tank and stirs 60min, that is, is made
The content；
S3：Temperature is controlled at 20 DEG C, by above-mentioned softgel shell glue and content automatic rotary transformation of ownership ball mechanism ball, shell thickness
Control as 0.8mm, capsule and pill surface oil stain washed away with ethanol, at 35 DEG C it is dry 15 it is small when, pack up to the vitamin D3It is soft
Capsule.
Embodiment 2：Vitamin D3Soft capsule.
The vitamin D of the embodiment of the present invention 23Soft capsule includes content and softgel shell, and the content includes following weight
The component of number：Vitamin D320 parts, vitamin D24 parts, 6 parts of walnut oil, 4 parts of eucommia ulmoides seed oil, 4 parts of granada seed oil, amino acid 9
Part, 2 parts of calcium citrate, 4.5 parts of antioxidant and 2 parts of stabilizer；The softgel shell includes the component of following parts by weight：Gelatin 35
Part, 15 parts of glycerine, 2 parts of titanium dioxide, 2 parts of iron oxide, 0.5 part of preservative and 15 parts of purified water.
Wherein, the antioxidant is made of 1.5 parts of 3 parts of vitamin C and vitamin E, and the stabilizer is by beeswax 0.5
1 part of part, 0.5 part of suet and soybean lecithin composition.
Preparation method：
S1：Above-mentioned purified water, glycerine, preservative is taken to add above-mentioned gelatin, temperature in being mixed evenly in stainless-steel pan
Stirring is depressurized in control at 36 DEG C, 60 DEG C is warming up to after gelatin expansion, stirring is completely dissolved gelatin particle；Add two
Titanium oxide and iron oxide, decompression stirring are allowed to dissolve completely uniformly, filtering, and 55 DEG C of insulations of filtrate are stood, up to softgel shell glue,
It is stand-by；
S2：Take above-mentioned beeswax, suet, soybean lecithin, vitamin C, vitamin E, vitamin D3And vitamin D2, mixing, is stirred
Mix uniformly；The walnut oil, eucommia ulmoides seed oil, granada seed oil, amino acid and calcium citrate are added, is stirred evenly, crosses colloid mill
Homogeneous 4 times, each homogeneous 20min, that is, be made the suspension of appearance uniform, then suspension be placed in material-compound tank and is stirred
80min, that is, be made the content；
S3：Temperature is controlled at 22 DEG C, by above-mentioned softgel shell glue and content automatic rotary transformation of ownership ball mechanism ball, shell thickness
Control as 0.9mm, capsule and pill surface oil stain washed away with ethanol, at 35 DEG C it is dry 15 it is small when, the dimension that packaging is made 300mg/ is given birth to
Plain D3Soft capsule.
Embodiment 3：Vitamin D3Soft capsule.
The vitamin D of the embodiment of the present invention 33Soft capsule includes content and softgel shell, and the content includes following weight
The component of number：Vitamin D330 parts, vitamin D26 parts, 10 parts of walnut oil, 6 parts of eucommia ulmoides seed oil, 6 parts of granada seed oil, amino acid
3 parts of 12 parts, 3 parts of calcium citrate, 6 parts of antioxidant and stabilizer；The softgel shell includes the component of following parts by weight：Gelatin 50
Part, 20 parts of glycerine, 3 parts of titanium dioxide, 3 parts of iron oxide, 1 part of preservative and 20 parts of purified water.
Wherein, the antioxidant is made of 2 parts of 4 parts of vitamin C and vitamin E, and the stabilizer is by beeswax 0.5
2 parts of part, 0.5 part of suet and soybean lecithin compositions.
Preparation method：
S1：Above-mentioned purified water, glycerine, preservative is taken to add above-mentioned gelatin, temperature in being mixed evenly in stainless-steel pan
Stirring is depressurized in control at 40 DEG C, 80 DEG C is warming up to after gelatin expansion, stirring is completely dissolved gelatin particle；Add two
Titanium oxide and iron oxide, decompression stirring are allowed to dissolve completely uniformly, filtering, and 60 DEG C of insulations of filtrate are stood, up to softgel shell glue,
It is stand-by；
S2：Take above-mentioned beeswax, suet, soybean lecithin, vitamin C, vitamin E, vitamin D3And vitamin D2, mixing, is stirred
Mix uniformly；The walnut oil, eucommia ulmoides seed oil, granada seed oil, amino acid and calcium citrate are added, is stirred evenly, crosses colloid mill
Homogeneous 5 times, each homogeneous 30min, that is, be made the suspension of appearance uniform, then suspension be placed in material-compound tank and is stirred
100min, that is, be made the content；
S3：Temperature is controlled at 24 DEG C, by above-mentioned softgel shell glue and content automatic rotary transformation of ownership ball mechanism ball, shell thickness
Control as 1.0mm, capsule and pill surface oil stain washed away with ethanol, at 35 DEG C it is dry 20 it is small when, the dimension that packaging is made 300mg/ is given birth to
Plain D3Soft capsule.
Comparative example 1：Vitamin D3Soft capsule.
The antioxidant is made of 3 parts of 1 part of vitamin C and vitamin E, remaining component such as embodiment 2.
Preparation method reference implementation example 2.
Comparative example 2：Vitamin D3Soft capsule.
The stabilizer is made of 1.5 parts of 0.5 part of beeswax and soybean lecithin, remaining component such as embodiment 2.
Preparation method reference implementation example 2.
Stability test
1st, trial drug and packet
1 group of embodiment：1 vitamin D of the embodiment of the present invention3Soft capsule；
2 groups of embodiment：2 vitamin D of the embodiment of the present invention3Soft capsule；
3 groups of embodiment：3-dimensional of embodiment of the present invention life element D3Soft capsule；
1 group of comparative example：1 vitamin D of comparative example of the present invention3Soft capsule；
2 groups of comparative example：2 vitamin D of comparative example of the present invention3Soft capsule；
Control group：Gummy shark vitamin D soft capsule.
2nd, test method
The fluorescent lamp of 1 ~ 3 group of above-described embodiment, 1 ~ 2 group of comparative example and control group trial drug in 3000 luxs is transferred
Put 200 it is small when after, using high performance liquid chromatograph, vitamin D in each group is obtained under following determination condition3Survival rate,
The visually soft capsule and the tone of the soft capsule wafer without light irradiation relatively after light irradiation, evaluates the stabilization of tone
Property.
Survival rate determination condition
Device：Shimadzu Seisakusho Ltd.'s high performance liquid chromatograph（Autoinjector-SIL-10A, liquor charging unit LC-10AD,
System controller SCL-10A, detector SPD-10A, column baking oven（column oven）CTD-10A/10AC, Chromatopack
C-R7Apuls）；Column：4.6 × 150mm of Waters SymmetryC18 3.5um；Sample size：200 microlitres（Sample solution concentration is about
125ng/ml）；Column temperature：25℃；Mobile phase：Acetonitrile：Water：Tetrahydrofuran：Acetic acid=1350：400：250：1（V/V）；Flow velocity：
1ml/min；Detector：UV detectors 265nm.
3rd, measurement result is as shown in table 1.
1 survival rate measurement result of table
| Group | Vitamin D3Survival rate（%） |
| Control group | 74.2 |
| 1 group of embodiment | 96.2 |
| 2 groups of embodiment | 98.1 |
| 3 groups of embodiment | 95.5 |
| 1 group of comparative example | 75.5 |
| 2 groups of comparative example | 70.1 |
4th, conclusion.
As seen from the above table, 1 ~ 3 group of vitamin D of the present embodiment3When fluorescent lamp 200 of the soft capsule through 3000 luxs is small
Afterwards, its survival rate is more than 90%, significantly larger than control group, wherein, with 2 groups of vitamin Ds of embodiment3The remaining of soft capsule
Rate highest, reaches 98.1%, therefore 2 groups of embodiment is preferred embodiment；1 group of comparative example, which changes, ties up life in antioxidant
The amount ratio of plain C and vitamin E, its survival rate is only 83.5%, hence it is evident that less than 1 ~ 3 group of embodiment, therefore can learn, vitamin C and
The amount of vitamin E compares vitamin D of the present invention3There is influence in the antioxygenic property of soft capsule；2 groups of comparative example changes stabilizer
Species composition, its survival rate is also significantly lower than 1 ~ 3 group of embodiment, it can be seen that, vitamin D of the present invention3Soft capsule vitamin C
Species with vitamin E, stabilizer is the optimised quantity ratio and species drawn by a large number of experiments screening, therefore, present invention dimension life
Plain D3Soft capsule is with good stability, it is not easy photodissociation and oxidation, retention cycle length.
In following experiment, since 1,2 group of stability of comparative example is bad, not as test target.
One vitamin D of the present invention of test example3Influence of the soft capsule to mouse brain function
1st, experimental animal and packet
Healthy mice 50 is chosen, half male and half female, 19 ~ 25g, is randomly divided into 5 groups, every group 10, be respectively present invention dimension
Raw element D3The high, medium and low dosage group of soft capsule, control group and model group.
2nd, medication
2 vitamin D of embodiment3Soft capsule high dose group, gavage give 45mg/kg；Gavage 1 time daily, continuous gavage 15
My god；
2 vitamin D of embodiment3Soft capsule middle dose group, gavage give 22.5mg/kg；Gavage 1 time daily, continuous gavage
15 days；
2 vitamin D of embodiment3Soft capsule low dose group, gavage give 11.5mg/kg；, daily gavage 1 time, continuous gavage
15 days；
Control group：Kang man of great strength's linseed oil soft capsule, gavage give 75mg/kg；Gavage 1 time daily, continuous gavage 15 days；
Model group：Gavage gives isometric physiological saline（10ml.kg-1）；Gavage 1 time daily, continuous gavage 15 days.
3rd, test method
Since administration the 16th day, every time administration after 2 it is small when, mouse is put into reaction chamber endoadaptation environment 3 minutes, then
Be powered immediately, mouse is subject to electric current to stimulate, its normal reaction be rebound platform to hide noxious stimulation, every time training 5 minutes,
And the number that every mouse is shocked by electricity is recorded, in this, as school grade.24 it is small when after repeat above-mentioned experiment, this i.e. remember protect
Test is held, record jumps off in the incubation period and 3 minutes of platform jump off stimulated number for the first time（Mistake sum）.
4th, statistical analysis
Each group test data is handled using SPSS17.0 software statistics, and more comparison among groupss use variance analysis, 0.05 tables of P ＜
Show that difference has statistically significant meaning.
5th, result of the test is as shown in table 2.
2 test result of table（± S, n=10）
Note：▲Compared with model group, p<0.05；▲▲Compared with model group, p<0.01；* compared with control group, p<0.05.
6th, conclusion
As shown in Table 2, successive administration is after 15 days, control group and 2 vitamin D of the embodiment of the present invention3Soft capsule is high, medium and low
Dosage group can significantly increase the learning and memory ability of mouse, and have significant difference compared with model group；Wherein with
2 vitamin D of the embodiment of the present invention3The learning and memory ability of soft capsule high dose group mouse is optimal；Control group is Kang Lishiya
Flaxseed oil soft capsule, its main component include linseed oil, fish oil and wheat-germ oil, it, which has, improves cerebral function, enhancing
Brain activity, strengthen immunity and other effects, 2 vitamin D of the embodiment of the present invention3Soft capsule high dose group compared with control group,
Significant difference p is respectively provided with terms of learning ability of mice and memory capability<0.05；It can be seen from the above that vitamin D of the present invention3Flexible glue
Effect of the capsule in terms of cerebral function is strengthened is better than Kang man of great strength's linseed oil soft capsule, i.e., vitamin D of the present invention3Soft capsule has
Significant enhancing cerebral function, the effect for improving memory.
Test two vitamin Ds of the present invention3Influence of the soft capsule to immune function of mice
1st, experimental animal and packet
Healthy mice 40 is chosen, half male and half female, 19 ~ 25g, is randomly divided into 4 groups, every group 10, be respectively present invention dimension
Raw element D3The high, medium and low dosage group of soft capsule and control group.
2nd, medication
2 vitamin D of embodiment3Soft capsule high dose group, gavage give 45mg/kg；Gavage 1 time daily, continuous gavage 15
My god；
2 vitamin D of embodiment3Soft capsule middle dose group, gavage give 22.5mg/kg；Gavage 1 time daily, continuous gavage
15 days；
2 vitamin D of embodiment3Soft capsule low dose group, gavage give 11.5mg/kg；, daily gavage 1 time, continuous gavage
15 days；
Model group：Gavage gives isometric physiological saline（10ml.kg-1）；Gavage 1 time daily, continuous gavage 15 days.
3rd, test method
Since administration the 16th day, after administration 6 it is small when post-tensioning neck put to death mouse, weigh every group of mouse thymus and spleen respectively
Weight（Represented with organ weight/10g weight）.
4th, statistical analysis
Each group test data is handled using SPSS17.0 software statistics, and more comparison among groupss use variance analysis, 0.05 tables of P ＜
Show that difference has statistically significant meaning.
5th, result of the test is as shown in table 3.
Influence of 3 embodiment of the present invention of table, the 2 vitamine D3 soft capsule to immune function of mice（± S, n=10）
| Group | N（Only） | Dosage（mg/kg） | Thymic weight（Mg/10g weight） | Spleen gland weight（Mg/10g weight） |
| Model group | 10 | - | 27.52±10.36 | 57.34±22.65 |
| High dose group | 10 | 45 | 35.28±14.07▲▲ | 63.12±25.09▲▲ |
| Middle dose group | 10 | 22.5 | 32.17±12.51▲▲ | 61.29±24.39▲▲ |
| Low dose group | 10 | 11.5 | 28.39±11.35 | 58.30±23.18 |
Note：▲Compared with model group, p<0.05；▲▲Compared with model group, p<0.01.
6th, conclusion.
As shown in Table 3, successive administration is after 15 days, compared with model group, 2 vitamin D of the embodiment of the present invention3Soft capsule height,
Middle group can significantly increase the weight of immune organ, and have significant difference compared with model group, wherein with high dose group
Effect is best, with it can be seen from the above that 2 vitamin D of the embodiment of the present invention3Soft capsule has the work for significantly increasing immune function of human body
With.
It is any in the spirit and/or scope of the present invention since by above preferred embodiment, the invention has been described
Implement the present invention for replacement/of the invention or combination, will be apparent from for those skilled in the art, and
Among the present invention.
Claims (5)
- A kind of 1. vitamin D3Soft capsule, including content and softgel shell, it is characterised in that the content includes following weight The component of number：Vitamin D310 parts, vitamin D21 part, 3 parts of walnut oil, 2 parts of eucommia ulmoides seed oil, 2 parts of granada seed oil, amino acid 6 Part, 1 part of calcium citrate, 3 parts of antioxidant and 1 part of stabilizer；The softgel shell includes the component of following parts by weight：Gelatin 25 Part, 15 parts of glycerine, 2 parts of titanium dioxide and 10 parts of purified water, wherein, the antioxidant is by 2 parts of vitamin C and vitamin E 1 part of composition, the stabilizer are made of 0.5 part of 0.2 part of beeswax, 0.3 part of suet and soybean lecithin.
- A kind of 2. vitamin D3Soft capsule, including content and softgel shell, it is characterised in that the content includes following weight The component of number：Vitamin D320 parts, vitamin D24 parts, 6 parts of walnut oil, 4 parts of eucommia ulmoides seed oil, 4 parts of granada seed oil, amino acid 9 Part, 2 parts of calcium citrate, 4.5 parts of antioxidant and 2 parts of stabilizer；The softgel shell includes the component of following parts by weight：Gelatin 35 Part, 15 parts of glycerine, 2 parts of titanium dioxide, 2 parts of iron oxide, 0.5 part of preservative and 15 parts of purified water, wherein, the antioxidant It is made of 1.5 parts of 3 parts of vitamin C and vitamin E, the stabilizer is by 0.5 part of beeswax, 0.5 part of suet and soybean lecithin 1 Part composition.
- A kind of 3. vitamin D3Soft capsule, including content and softgel shell, it is characterised in that the content includes following weight The component of number：Vitamin D330 parts, vitamin D26 parts, 10 parts of walnut oil, 6 parts of eucommia ulmoides seed oil, 6 parts of granada seed oil, amino acid 3 parts of 12 parts, 3 parts of calcium citrate, 6 parts of antioxidant and stabilizer；The softgel shell includes the component of following parts by weight：Gelatin 50 Part, 20 parts of glycerine, 3 parts of titanium dioxide, 3 parts of iron oxide, 1 part of preservative and 20 parts of purified water, wherein, the antioxidant by 2 parts of compositions of 4 parts of vitamin C and vitamin E, the stabilizer is by 2 parts of 0.5 part of beeswax, 0.5 part of suet and soybean lecithin groups Into.
- 4. such as claim 1-3 any one of them vitamin Ds3The preparation method of soft capsule, it is characterised in that including following step Suddenly：S1：Purified water and glycerine are weighed respectively in being mixed evenly in stainless-steel pan, add the gelatin, temperature control is 30 Stirring is depressurized at ~ 40 DEG C, 50 ~ 80 DEG C are warming up to after gelatin expansion, stirring is completely dissolved above-mentioned gelatin particle；Add The titanium dioxide, decompression stirring are allowed to dissolve completely uniformly, filtering, and 50 ~ 60 DEG C of insulations of filtrate are stood, up to softgel shell glue, It is stand-by；S2：The stabilizer, antioxidant, vitamin D are weighed respectively3And vitamin D2, it is mixed evenly；Add the core Peach oil, eucommia ulmoides seed oil, granada seed oil, amino acid and calcium citrate, stir evenly, and cross colloid mill homogeneous 3 ~ 5 times, every time 15 ~ 30min of matter, that is, be made the suspension of appearance uniform, and suspension is placed in 60 ~ 100min of stirring in material-compound tank, that is, institute is made State content；S3：Temperature is controlled at 20 ~ 25 DEG C, by above-mentioned softgel shell glue and content automatic rotary transformation of ownership ball mechanism ball, shell thickness Control as 0.8 ~ 1.0mm, capsule and pill surface oil stain washed away with ethanol, at 30 ~ 35 DEG C it is dry 10 ~ 20 it is small when, pack up to described Vitamin D3Soft capsule.
- 5. vitamin D as claimed in claim 43The preparation method of soft capsule, it is characterised in that added in the S1 steps Preservative and iron oxide.
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| CN109662953B (en) * | 2019-02-18 | 2022-05-10 | 威海金思力生物科技股份有限公司 | Vitamin D soft capsule and preparation method thereof |
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| NL2029172B1 (en) * | 2021-09-10 | 2023-03-21 | Liposoma Health B V | Lipid formulations for the preparation of health ingredient-containing hot drinks |
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