CN102920750A - Health-care compound preparation for nourishing brain and improving eyesight - Google Patents
Health-care compound preparation for nourishing brain and improving eyesight Download PDFInfo
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- CN102920750A CN102920750A CN2012104666347A CN201210466634A CN102920750A CN 102920750 A CN102920750 A CN 102920750A CN 2012104666347 A CN2012104666347 A CN 2012104666347A CN 201210466634 A CN201210466634 A CN 201210466634A CN 102920750 A CN102920750 A CN 102920750A
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- lecithin
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- folium ginkgo
- phylloxanthin
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Abstract
The invention relates to a compound preparation, which contains the following raw materials by mass percentage: 10% to 40% of lecithin, 20% to 80% of linoleic acid, 5% to 30% of ginkgo biloba extract, 0.5% to 15% of xanthophyll and 0.02% to 0.5% of vitamin E; the raw materials of the compound preparation by mass percentage are as follows: 30% to 45% of sunflower oil, 18% to 28% of powdery lecithin with purity of above 98%, 8% to 16% of ginkgo biloba extract, 1% to 5% of xanthophylls, 9% to 15% of taurine and 6% to 15% of polyethylene glycol 400. The heath-care product is utilized to supplement the shortages of the human lecithin and xanthophyll, is beneficial to preventing and treating the cardiovascular diseases and protecting eyesight, and has the effects on nourishing the brain and improving eyesight and enhancing the immunity.
Description
Technical field
The present invention relates to a kind of compound health preparation, be specifically related to a kind of lecithin that contains, ginkgetin, the brain nourishing and eyesight improving compound formulation of phylloxanthin and sunflower oil.
Background technology
Sunflower oil is rich in the unsaturated fatty acid linoleic acid of needed by human, other benefit materials such as vitamin E and sterol, and wherein and linoleic acid content can reach 70%, the content of vitamin E is the highest in all main plant oil.Sunflower oil has blood fat reducing, vessel softening, the microcirculatory effect of promotion, helps growth promoter, nourishing the brain and improving intelligence.
Lecithin is the important component that consists of cell membrane, content is very high in brain cell, to strengthening function of brain cell, improve the brain vigor, promote nerve conduction, promote lipid metabolism, improve blood circulation, the cardiovascular and cerebrovascular disease that effectively prevents and improve hyperlipidemia to cause plays an important role, and is recommended as one of essential nutrient that replenishes every day by the United States Federal's food and drug control committee (FDA).
Ginkgetin can improve cardiovascular and cerebrovascular vessel, increases arterial vascular elasticity and permeability, improves cerebral blood flow, improves the brain circulation, and functional central nervous system injury is had obvious repair function, is one of important nutrient of brain health care.
Phylloxanthin is as a kind of natural anti-oxidation pigment, non-toxic and safe, the physiological function with multiple excellence.At first, phylloxanthin has the inhibition reactive oxygen free radical, and the immunocompetence of enhancing body is regulated blood fat, prevents that low density lipoprotein, LDL is oxidized, reduces the oxidisability of LDL-C, alleviates cardiopathic danger.In addition, the main component of macula lutea in phylloxanthin or the eyes has preventive effect to senile macula retinae degeneration, can improve old people's vision decline, and prevention is owing to old and feeble muscle deterioration disease such as the blindness causing disease that occurs.Because phylloxanthin can not produce in human body, must additionally replenish.
By certain proportion with above-mentioned lecithin, ginkgetin, phylloxanthin, sunflower wet goods nutritive and health protection components compatibility can reach warming the meridian and promoting blood circulation together, soothing the liver making eye bright, blood vessel dilating, blood circulation promoting, the protection brain cell, the purpose of enhancing immunity.
Summary of the invention
One of purpose of the present invention is for providing a kind of compound formulation: this compound formulation contains following composition with mass percent:
Lecithin 10-40%, linoleic acid 20-80%, Folium Ginkgo extract 5-30%, phylloxanthin 0.5-15% and vitamin E 0.02-0.5%.
The raw material of this compound formulation consists of take mass percent: sunflower oil: 30～45%, purity is the powdery lecithin more than 98%: 18～28%, Folium Ginkgo extract: 8～16%, phylloxanthin extract: 1～5%, taurine: 9～15% and PEG400: 6～15%.
Described powdery lecithin is preferably refining soybean lecithin.
Folium Ginkgo extract is ginkgetin in the raw material, and total flavone glucoside content is 24～60% in its composition, and bilobalide is 6～32%; The content requirement of described raw material Lutein extract Lutein is more than 90%.
Described sunflower oil is preferably the Helianthi that originates in the Baya ur, NeiMengGu area and obtains through cold pressing process, and the linoleic acid content of described sunflower oil is not less than 65%.
Purpose of the present invention two for the preparation method that changes compound formulation is provided: comprise the steps:
Step 1: batching: be formulated as follows raw material take mass percent: sunflower oil: 30～45%, purity is the powdery more than 98%
Lecithin: 18～28%, Folium Ginkgo extract: 8～16%, phylloxanthin extract: 1～5%, taurine: 9～15% and
PEG400: 6～15%;
Step 2: Folium Ginkgo and thing phylloxanthin are extracted according to the above ratio mixing, join in the PEG400, stir;
Step 3: with sunflower oil, lecithin and taurine add in the mixture that step 2 obtains successively according to the ratio in the step 1, and mixing is with high-shear homogenizer homogenizing under 15-25 ℃ and 20000psi condition;
Step 4: will place in the storage tank of encapsulating machine through the mixed liquor behind the step 3 homogenizing, and make gelatin soft capsule.
As preferably, the leaching process of described Folium Ginkgo extract is:
(a) Folium Ginkgo is behind conventional alcohol steep, and lixiviating solution adds and is water-cooled to the room temperature crude separation;
(b) with in the adsorbent suzerain adsorption column, the separating medium that step (a) is obtained carries out adsorption-edulcoration with 1000L/ hour flow;
(c) effluent after the remove impurity is through resin purification;
(d) after the refined liquid process vacuum concentration drying that step (c) is obtained, namely get the Folium Ginkgo extract of impurity removal and purification.
Compound formulation involved in the present invention contains lecithin 20-30%, and wherein lecithin is food stage or pharmaceutical grade, is provided by refining soybean lecithin, and purity is more than 98%.
Compound formulation involved in the present invention contains phylloxanthin 2-5%, and its Lutein is food stage or pharmaceutical grade, is provided by the fresh Flos Tagetis Erectae extract, and purity is more than 90%.
Compound formulation involved in the present invention also contains the interpolation taurine, and brain cell is had protective effect.
Compound formulation involved in the present invention also contains edible or pharmaceutic adjuvant, such as Polyethylene Glycol, and gelatin, glycerol, deionized water.
The compound formulation that the present invention relates to can be the form of soft capsule; every capsules content 300mg-800mg; every capsules contains Oleum Helianthi 100mg-400mg; contain lecithin 50-300mg; Folium Ginkgo extract 25-100mg; phylloxanthin extract 5-15mg, taurine 10-20mg, other right amount of auxiliary materials.
Advantage of the present invention: the present invention is exactly the promotion neurodevelopment according to lecithin, strengthens the function of brain cell; The ginkgetin blood vessel dilating improves blood circulation; Vitamin E is removed free radical; linoleic acid promotes the refreshment brain strengthening functions such as brain cell development, and the vision protection of phylloxanthin, and is anti-aging in advance; the effects such as enhancing immunity; prepare a kind ofly with sunflower oil, lecithin, ginkgetin and phylloxanthin are the compound oral formulations of raw material; reach and make the Fructus Alpiniae Oxyphyllae of child's benefit heart; the middle age brain-strengthening is preserved youthful looks, the purpose that the old people prolongs life and makes eye bright, and appeal to all ages time personage takes this compound formulation.
The specific embodiment
The preparation method of compound formulation involved in the present invention is as follows; Semen Ginkgo extrac and phylloxanthin are added in an amount of Polyethylene Glycol, stir, then add in proportion sunflower oil; lecithin; taurines etc. fully mix, with colloid mill or the abundant homogenizing of homogenizer, then according to the soft capsule preparation method; utilize gelatin; glycerol is capsule wall, makes soft capsule, also can be made into drop or other dosage form.
Following instance is used for explanation the present invention, but should not be considered as restriction of the present invention.
Example one
A kind of preparation method of compound formulation is characterized in that:
The first step: Folium Ginkgo and phylloxanthin extract are mixed in proportion, join in the PEG400, stir.
Second step: with sunflower oil, lecithin and taurine add in the said mixture successively, and mixing is with high-shear homogenizer homogenizing under 15-25 ℃ and 20000psi condition.
The 3rd step: mixed liquor behind the homogenizing is placed in the storage tank of encapsulating machine, make 1200 gelatin soft capsules.
The heavy 680mg of every soft capsule content, linoleic acid 150mg wherein, vitamin E 0.25mg, lecithin 175mg, Folium Ginkgo extract 58mg, phylloxanthin extract 16mg.
Embodiment two:
A kind of preparation method of compound formulation is characterized in that:
The first step: Folium Ginkgo and phylloxanthin extract are mixed in proportion, join in the PEG400, stir.
Second step: with sunflower oil, lecithin and taurine add in the said mixture successively, and mixing is with high-shear homogenizer homogenizing under 15-25 ℃ and 20000psi condition.
The 3rd step: intimate mixing liquid is placed in the storage tank of encapsulating machine, make 1500 gelatin soft capsules.
Every heavy 650mg of soft capsule content contains linoleic acid 160mg, vitamin E 0.28mg, lecithin 133mg, Folium Ginkgo extract 80mg, phylloxanthin extract 20mg.
Embodiment three:
A kind of preparation method of compound formulation is characterized in that:
The first step: Folium Ginkgo and phylloxanthin extract are mixed in proportion, join in the PEG400, stir.
Second step: with sunflower oil, lecithin and taurine add in the said mixture successively, and mixing is with high-shear homogenizer homogenizing under 15-25 ℃ and 20000psi condition.
The 3rd step: intimate mixing liquid is placed in the storage tank of encapsulating machine, make 1200 gelatin soft capsules.Every heavy 570mg of soft capsule content contains linoleic acid 130mg, vitamin E 0.22mg, lecithin 200mg, Folium Ginkgo extract 58mg, phylloxanthin extract 17mg.
Claims (8)
1. compound formulation, it is characterized in that: this compound formulation contains following composition with mass percent:
Lecithin 10-40%, linoleic acid 20-80%, Folium Ginkgo extract 5-30%, phylloxanthin 0.5-15% and vitamin E 0.02-0.5%.
2. compound formulation according to claim 1, it is characterized in that: the raw material of this compound formulation consists of take mass percent: sunflower oil: 30～45%, purity is the powdery lecithin more than 98%: 18～28%, Folium Ginkgo extract: 8～16%, phylloxanthin extract: 1～5%, taurine: 9～15% and PEG400: 6～15%.
3. compound formulation according to claim 2 is characterized in that: described powdery lecithin is refining soybean lecithin.
4. compound formulation according to claim 2, it is characterized in that: Folium Ginkgo extract is ginkgetin in the described raw material, and total flavone glucoside content is 24～60% in its composition, and bilobalide is 6～32%; The content requirement of described raw material Lutein extract Lutein is more than 90%; , described phylloxanthin extract obtains for being extracted by fresh Flos Tagetis Erectae.
5. compound formulation according to claim 2 is characterized in that: described sunflower oil is that the Helianthi that originates in the Baya ur, NeiMengGu area obtains through cold pressing process, and the linoleic acid content of described sunflower oil is not less than 65%.
6. compound formulation according to claim 2, it is characterized in that: this compound formulation also adds gelatin, and glycerol and deionized water are as adjuvant.
7. the preparation method of each described compound formulation of claim 1-6 is characterized in that: comprise the steps:
Step 1: batching: be formulated as follows raw material take mass percent: sunflower oil: 35～45%, purity is the powdery lecithin more than 98%: 18～28%, Folium Ginkgo extract: 8～16%, phylloxanthin extract: 1～5%, taurine: 9～15% and PEG400: 6～15%;
Step 2: Folium Ginkgo and thing phylloxanthin are extracted according to the above ratio mixing, join in the PEG400, stir;
Step 3: with sunflower oil, lecithin and taurine add in the mixture that step 2 obtains successively according to the ratio in the step 1, and mixing is with high-shear homogenizer homogenizing under 15-25 ℃ and 20000psi condition;
Step 4: will place in the storage tank of encapsulating machine through the mixed liquor behind the step 3 homogenizing, and make gelatin soft capsule.
8. the preparation method of described compound formulation according to claim 7, it is characterized in that: the leaching process of described Folium Ginkgo extract is:
(a) Folium Ginkgo is behind conventional alcohol steep, and lixiviating solution adds and is water-cooled to the room temperature crude separation;
(b) with in the adsorbent suzerain adsorption column, the separating medium that step (a) is obtained carries out adsorption-edulcoration with 1000L/ hour flow;
(c) effluent after the remove impurity is through resin purification;
(d) after the refined liquid process vacuum concentration drying that step (c) is obtained, namely get the Folium Ginkgo extract of impurity removal and purification.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012104666347A CN102920750A (en) | 2012-11-19 | 2012-11-19 | Health-care compound preparation for nourishing brain and improving eyesight |
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| CN2012104666347A CN102920750A (en) | 2012-11-19 | 2012-11-19 | Health-care compound preparation for nourishing brain and improving eyesight |
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| CN105188410A (en) * | 2013-03-13 | 2015-12-23 | 雅培制药有限公司 | Prenatal and lactation supplements to enhance central nervous system development of offspring |
| CN109043537A (en) * | 2018-08-01 | 2018-12-21 | 黑龙江仁合堂药业有限责任公司 | A kind of health food and preparation method thereof improving immunity |
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Cited By (2)
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| CN105188410A (en) * | 2013-03-13 | 2015-12-23 | 雅培制药有限公司 | Prenatal and lactation supplements to enhance central nervous system development of offspring |
| CN109043537A (en) * | 2018-08-01 | 2018-12-21 | 黑龙江仁合堂药业有限责任公司 | A kind of health food and preparation method thereof improving immunity |
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Application publication date: 20130213 |