KR20140017976A - Vita hybrid tablet for student and manufacturing method thereof - Google Patents
Vita hybrid tablet for student and manufacturing method thereof Download PDFInfo
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- KR20140017976A KR20140017976A KR1020120085112A KR20120085112A KR20140017976A KR 20140017976 A KR20140017976 A KR 20140017976A KR 1020120085112 A KR1020120085112 A KR 1020120085112A KR 20120085112 A KR20120085112 A KR 20120085112A KR 20140017976 A KR20140017976 A KR 20140017976A
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- vitamin
- vita
- coating
- hybrid
- hydrochloride
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
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Abstract
Description
본 발명은 수험생을 위한 수험생용 건강기능식품 및 그 제조 방법에 관한 것으로, 보다 상세하게는 수험생에게 부족한 영양을 공급해 주고, 피로회복과 두뇌 건강을 향상시켜 주는 수험생용 비타 하이브리드 정제 및 그 제조 방법에 관한 것이다.
The present invention relates to an examinee health functional food for the examinee and a method for manufacturing the same, and more specifically, to the examinee vita hybrid tablets and the method for supplying the examinee insufficient nutrition, improves fatigue recovery and brain health It is about.
일반적으로 중·고등학교의 재학생은 물론이고 대학생 및 각종 시험을 준비하는 수험생들은 타인보다 좋은 성적을 얻기 위한 치열한 경쟁으로 인하여 과중한 스트레스와 피로를 겪게 될 뿐만 아니라, 눈과 귀를 통하여 집중한 상태에서 수많은 정보들을 받아들여야 하며, 두뇌 활동을 통하여 이를 이해하고 기억해야 한다.In general, students in middle and high school as well as college students and candidates preparing for exams are not only subject to heavy stress and fatigue due to intense competition for better grades than others, but also concentrated in the eyes and ears. You must accept the information and understand and remember it through your brain activity.
이와 같이, 수험생들은 항상 육체적 및 정신적으로 스트레스와 피로에 노출되어 있고, 장시간 두뇌 활동을 통하여 집중한 상태에서 학습을 해야 하며, 또한 많은 학습 정보들을 기억해야 한다.In this way, the candidates are always physically and mentally exposed to stress and fatigue, have to learn in a concentrated state through long-term brain activity, and also remember a lot of learning information.
이러한 수험생을 위한 종래의 건강기능식품으로서, 대한민국 공개특허공보 제10-2011-0057480호에는 L-아스코르빈산 및 L-아스코르빈산염, 바람직하기는 L-아스코르빈산 및 L-아스코르빈산 나트륨이 1:0.85~2의 중량비로 혼합된 L-아스코르빈산의 혼합물을 직타법으로 가공하여 제조된 비타민 정제에 관하여 개시되어 있다.As a conventional health functional food for such examinees, Korean Unexamined Patent Publication No. 10-2011-0057480 discloses L-ascorbic acid and L-ascorbic acid salt, preferably L-ascorbic acid and L-ascorbic acid. A vitamin tablet prepared by processing a mixture of L-ascorbic acid in which sodium is mixed in a weight ratio of 1: 0.85 to 2 is disclosed.
그러나, 상기 종래의 기술은 비타민C를 활성성분으로 하여 기호도가 우수하고 씹거나 녹여서 섭취하기에 적합한 제품을 제공할 수는 있으나, 성장기의 수험생에게 특히 필요한 여러 가지의 비타민과 미네랄 등을 공급할 수 없고, 이로 인하여 수험생의 스트레스와 피로를 회복시켜 주는 데 한계가 있음은 물론, 기억력과 집중력 강화에는 효과가 없어 학습능력 증진에 도움이 되지 못하며, 대부분 인공 추출물을 사용하여 체내 흡수율이 낮은 문제가 있었다.
However, the conventional technology can provide a product that is excellent in preference and suitable for chewing or melting by using vitamin C as an active ingredient, but cannot supply various vitamins and minerals, which are particularly necessary for the examinee during the growing season. Because of this, there is a limit in restoring the examinee's stress and fatigue, as well as the effect of strengthening memory and concentration is not effective in improving learning ability. Most artificial extracts have a problem of low absorption rate.
본 발명은 상술한 문제들을 모두 해결하기 위하여 안출된 것으로, 각종 비타민과 미네랄 및 기능성 천연 추출물을 함유한 건강기능식품을 수험생에게 제공함으로써, 성장기의 수험생에게 부족한 비타민과 미네랄 등의 영양을 공급하여 균형있는 성장에 도움을 줄 뿐만 아니라, 두뇌의 혈행개선을 통해 뇌 유입 혈류량을 증가시켜 뇌 기능을 향상시켜 주고, 수험 스트레스로 인한 피로를 회복시켜 주어 신체의 피로를 개선시킴은 물론, 기억력 및 집중력을 강화시켜 학습력을 증진시켜 주는 수험생용 비타 하이브리드 정제 및 그 제조 방법의 제공을 그 목적으로 한다.
The present invention has been made to solve all the above problems, by providing a dietary supplement containing various vitamins, minerals and functional natural extracts to the examinee, by supplying nutrition, such as vitamins and minerals insufficient to the examinee in the growing season It not only helps to grow fast, but also improves brain function by improving blood flow to the brain, improving brain function, and recovering from fatigue caused by examination stress, improving body fatigue as well as improving memory and concentration. An object of the present invention is to provide a veterinary vita hybrid tablet and a method for producing the same, which enhances learning ability.
상기 과제를 해결하기 위하여 본 발명은 중량%로, 비타민A 혼합제 0.5 내지 5%, 비타민B1 염산염 0.03 내지 0.3%, 비타민B2 0.03 내지 0.3%, 비타민B6 염산염 0.05 내지 0.5%, 비타민C 5 내지 15%, 엽산 0.01 내지 0.1%, 산화아연 0.2 내지 2%, 황산망간 0.15 내지 1.5%을 포함한 활성성분; 결정셀룰로오스와 유당혼합분말 중에서 선택된 1종 또는 2종이 60 내지 80%를 포함한 부형제; 0.5 내지 5%를 갖는 코팅제; 및 기타 첨가제를 포함하는 수험생용 비타 하이브리드 정제를 제공한다.In order to solve the above problems, the present invention is a weight%, vitamin A mixture 0.5 to 5%, vitamin B1 hydrochloride 0.03 to 0.3%, vitamin B2 0.03 to 0.3%, vitamin B6 hydrochloride 0.05 to 0.5%, vitamin C 5 to 15% Active ingredients, including folic acid 0.01-0.1%, zinc oxide 0.2-2%, manganese sulfate 0.15-1.5%; Excipients containing 60 to 80% of one or two selected from crystalline cellulose and lactose mixed powder; Coating agents having 0.5 to 5%; And it provides an examinee vita hybrid tablet comprising other additives.
이때, 상기 활성성분은 홍경천 추출물 1 내지 5%, 오양자 추출물 0.2 내지 2%, 가시오가피 추출물 0.15 내지 1.5%로 이루어진 군에서 선택된 1종 이상이 더 포함되는 것에도 그 특징이 있다.At this time, the active ingredient is characterized in that it further comprises one or more selected from the group consisting of 1-5% honggyeongcheon extract, 0.2 ~ 2% of yangja extract, 0.15 to 1.5% of thorn skin extract.
게다가, 상기 활성성분은 은행잎 추출물 0.5 내지 3%, 정제어유분말 0.05 내지 0.5%로 이루어진 군에서 선택된 1종 이상이 더 포함되는 것에도 그 특징이 있다.In addition, the active ingredient is characterized in that it further comprises one or more selected from the group consisting of ginkgo leaf extract 0.5 to 3%, purified fish oil powder 0.05 to 0.5%.
뿐만 아니라, 상기 활성성분은 원지 추출물 0.05 내지 0.5%, 황금 추출물 0.05 내지 0.5%로 이루어진 군에서 선택된 1종 이상이 더 포함되는 것에도 그 특징이 있다.In addition, the active ingredient is characterized in that it further comprises one or more selected from the group consisting of 0.05 ~ 0.5% of the original paper extract, 0.05 to 0.5% golden extract.
나아가, 상기 활성성분은 건조효모분말 0.15 내지 1.5%를 더 포함하는 것에도 그 특징이 있다.Furthermore, the active ingredient is characterized in that it further comprises 0.15 to 1.5% of dry yeast powder.
더불어, 상기 부형제는 결정셀룰로오스와 유당혼합분말을 모두 포함하고, 상기 결정셀룰로오스와 유당혼합분말의 혼합비가 중량 기준으로 1:0.4 내지 1:0.6인 것에도 그 특징이 있다.In addition, the excipient includes both crystalline cellulose and lactose mixed powder, and the mixing ratio of the crystalline cellulose and lactose mixed powder is characterized in that 1: 0.4 to 1: 0.6 by weight.
그리고, 상기 코팅제는 히드록시프로필메틸셀룰로오스, 피마자유, 프로필렌글리콜, 폴리에틸렌글리콜, 포비돈, 탈크, 탄산칼슘, 카르나우바납, 이산화규소, 메타아크릴산 공중합체 및 산화티탄으로 이루어진 군에서 선택된 1종 이상으로 이루어지는 것에도 그 특징이 있다.In addition, the coating agent is at least one selected from the group consisting of hydroxypropyl methyl cellulose, castor oil, propylene glycol, polyethylene glycol, povidone, talc, calcium carbonate, carnauba wax, silicon dioxide, methacrylic acid copolymer and titanium oxide It also has its characteristics.
이와 함께, 상기 첨가제는 카르복시메틸셀룰로오스칼슘 0.5 내지 3%, 스테아린산마그네슘 0.5 내지 1.5%를 포함하는 것에도 그 특징이 있다.In addition, the additive is also characterized in that it comprises 0.5 to 3% of carboxymethyl cellulose calcium, 0.5 to 1.5% of magnesium stearate.
또한, 본 발명은 각 원료를 전자저울로 칭량하는 칭량 단계; 중량%로, 비타민A 혼합제 0.5 내지 5%, 비타민B1 염산염 0.03 내지 0.3%, 비타민B2 0.03 내지 0.3%, 비타민B6 염산염 0.05 내지 0.5%, 비타민C 5 내지 15%, 엽산 0.01 내지 0.1%, 산화아연 0.2 내지 2%, 황산망간 0.15 내지 1.5%을 포함한 활성성분과, 결정셀룰로오스와 유당혼합분말 중에서 선택된 1종 또는 2종이 60 내지 80%를 포함한 부형제와, 기타 첨가제를 혼합기에 투입한 후 20 ~ 40분 동안 15 ~ 30 RPM으로 혼합하여 혼합물을 만드는 혼합 단계; 상기 혼합물을 자동 타정기를 이용하여 일정량으로 타정하는 타정 단계; 및 0.5 내지 5%의 코팅제를 주정알콜에 녹여서 코팅기제를 제조한 후 타정된 정제를 코팅기에서 코팅하는 코팅 단계;를 포함하는 수험생용 비타 하이브리드 정제의 제조 방법을 제공한다.
In addition, the present invention comprises a weighing step of weighing each raw material with an electronic balance; By weight%, Vitamin A admixture 0.5 to 5%, Vitamin B1 hydrochloride 0.03 to 0.3%, Vitamin B2 0.03 to 0.3%, Vitamin B6 hydrochloride 0.05 to 0.5%, Vitamin C 5 to 15%, Folic acid 0.01 to 0.1%, Zinc oxide The active ingredient containing 0.2 to 2%, manganese sulfate 0.15 to 1.5%, an excipient containing 60 to 80% of one or two selected from crystalline cellulose and lactose mixed powder, and other additives, 20 to 40 A mixing step of mixing at 15-30 RPM for minutes to make a mixture; A tableting step of tableting the mixture in a predetermined amount using an automatic tableting machine; It provides a method for producing a student vita hybrid tablet comprising a; and a coating step of preparing a coating base by dissolving 0.5 to 5% of the coating agent in alcohol alcohol and coating the tablet tablet in a coating machine.
본 발명에 의하면, 각종 비타민과 미네랄 및 기능성 천연 추출물을 함유한 건강기능식품을 수험생에게 제공함으로써, 성장기의 수험생에게 부족한 비타민과 미네랄 등의 영양을 공급하여 균형있는 성장에 도움을 줄 뿐만 아니라, 두뇌의 혈행개선을 통해 뇌 유입 혈류량을 증가시켜 뇌 기능을 향상시켜 주고, 수험 스트레스로 인한 피로를 회복시켜 주어 신체의 피로를 개선시킴은 물론, 기억력 및 집중력을 강화시켜 학습력을 증진시키는 우수한 효과가 있다.
According to the present invention, by providing the examinee with a dietary supplement containing various vitamins, minerals and functional natural extracts, the examinee not only assists the growth of the brain by providing nutrients such as vitamins and minerals that are lacking in the growing season. Improves blood flow through the brain, improves brain function by increasing blood flow, improves brain fatigue by restoring fatigue caused by examination stress, and improves memory and concentration. .
도 1은 본 발명에 따른 수험생용 비타 하이브리드 정제의 제조 방법의 플로우 차트.1 is a flow chart of a method for producing a student vita hybrid tablet according to the present invention.
본 발명자는 종래의 수험생을 위한 건강기능식품은 성장기의 수험생에게 특히 필요한 여러 가지의 비타민과 미네랄 등을 공급할 수 없고, 이로 인하여 수험생의 스트레스와 피로를 회복시켜 주는 데 한계가 있음은 물론, 기억력과 집중력 강화에는 효과가 없어 학습능력 증진에 도움이 되지 못하며, 대부분 인공 추출물을 사용하여 체내 흡수율이 낮은 문제가 있음을 인지하고, 이를 해결하기 위하여 연구와 노력을 거듭한 결과, 각종 비타민과 미네랄 및 기능성 천연 추출물을 함유한 건강기능식품을 수험생에게 제공함으로써, 성장기의 수험생에게 부족한 비타민과 미네랄 등의 영양을 공급하여 균형있는 성장에 도움을 줄 뿐만 아니라, 두뇌의 혈행개선을 통해 뇌 유입 혈류량을 증가시켜 뇌 기능을 향상시켜 주고, 수험 스트레스로 인한 피로를 회복시켜 주어 신체의 피로를 개선시킴은 물론, 기억력 및 집중력을 강화시켜 학습력을 증진시키는 우수한 수험생용 비타 하이브리드 정제 및 그 제조 방법에 관한 본 발명을 완성시켰다.The inventors of the present invention can not supply a variety of vitamins and minerals that are particularly necessary for the examinee in the growth phase of the conventional examinee, and thus there is a limit to recover the stress and fatigue of the examinee, memory and As it is not effective in enhancing concentration, it does not help to improve learning ability.Recognized that there is a problem of low absorption rate in the body using most artificial extracts. As a result of research and efforts to solve this problem, various vitamins, minerals and functionalities By providing health functional foods containing natural extracts to the examinees, they provide nutrition for vitamins and minerals, which are lacking for the examinees in the growing season, and help to balance growth, and increase blood flow into the brain through improving blood circulation in the brain. Improves brain function and relieves fatigue from exam stress Given on Sikkim improve the fatigue of the body, as well as to enhance memory and concentration, and completed the present invention relates to an excellent candidate Vita hybrid tablet and a manufacturing method for promoting hakseupryeok.
본 발명에 따른 수험생용 비타 하이브리드 정제는 크게 활성성분, 부형제, 코팅제 및 기타 첨가제를 포함하여 이루어진다.Student Vita hybrid tablets according to the present invention largely comprise the active ingredient, excipients, coatings and other additives.
상기 활성성분은 수험생의 성장과 발육 및 두뇌 회전에 필요한 각종 비타민과 미네랄 및 기능성 천연 추출물을 포함하고 있다.The active ingredient contains various vitamins, minerals and functional natural extracts necessary for the growth and development of the examinee and brain rotation.
즉, 상기 활성성분은 중량%로, 비타민A 혼합제 0.5 내지 5%, 비타민B1 염산염 0.03 내지 0.3%, 비타민B2 0.03 내지 0.3%, 비타민B6 염산염 0.05 내지 0.5%, 비타민C 5 내지 15%, 엽산 0.01 내지 0.1%, 산화아연 0.2 내지 2%, 황산망간 0.15 내지 1.5%을 포함한다.That is, the active ingredient in weight%, vitamin A mixture 0.5 to 5%, vitamin B1 hydrochloride 0.03 to 0.3%, vitamin B2 0.03 to 0.3%, vitamin B6 hydrochloride 0.05 to 0.5%, vitamin C 5 to 15%, folic acid 0.01 To 0.1%, zinc oxide 0.2 to 2%, and manganese sulfate 0.15 to 1.5%.
상기 비타민A 혼합제는 비타민A를 주성분으로 함유하고, 그 밖에 말토덱스트린, 옥수수 전분, 아라비아검, 레티닐 아세트산염, DL-알파-토코페롤이 혼합되어 구성된다.The vitamin A admixture contains vitamin A as a main ingredient, in addition to maltodextrin, corn starch, gum arabic, retinyl acetate, DL-alpha-tocopherol is mixed.
상기 비타민A는 지용성 비타민으로서, 신체의 저항력을 강화시키고, 생체막(membrane)의 조직 구조와 기능을 조절하며, 상피세포의 성장인자로서 세포의 재생을 촉진시켜 구강, 기도, 위, 장의 점막을 보호하고, 세포의 산화를 막아주는 항산화제 역할을 하며, 눈의 망막에 있는 간상세포에 존재하는 감광색소인 로돕신(rhodopsin)의 생산에도 관여하여 어두운 곳에서 시각 적응을 위해 필요한 물질로 알려져 있다.The vitamin A is a fat-soluble vitamin, strengthens the body's resistance, regulates the tissue structure and function of the membrane (membrane), and promotes cell regeneration as a growth factor of epithelial cells to protect the mucous membrane of the oral cavity, airway, stomach and intestine In addition, it acts as an antioxidant to prevent the oxidation of cells, and is involved in the production of rhodopsin, a photosensitive pigment present in rod cells in the retina of the eye, and is known as a material necessary for visual adaptation in the dark.
여기서 상기 비타민A 혼합제는 0.5 내지 5 중량%를 함유하는 것이 바람직한 바, 상기 비타민A 혼합제가 0.5 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 비타민A 혼합제가 5 중량%를 초과하면 과량 섭취로 인하여 오히려 피로감, 두통, 설사 및 어지러움 등의 독성 효과가 발생할 수 있기 때문이다.Wherein the vitamin A admixture preferably contains 0.5 to 5% by weight, if the vitamin A admixture is less than 0.5% by weight is insufficient expression of the above-described effect, if the vitamin A admixture exceeds 5% by weight is excessive Ingestion may cause toxic effects such as fatigue, headache, diarrhea and dizziness.
상기 비타민B1 염산염은 C12H17ON4ClS·HCl의 화학식을 갖는 물질로서, 공기 중에서 안정하고, 물에 잘 용해되는 성질을 갖고 있다.The vitamin B1 hydrochloride is a substance having a chemical formula of C 12 H 17 ON 4 ClS.HCl, and is stable in air and has a property of being well soluble in water.
상기 비타민B1은 수용성 비타민에 속하며, 탄수화물과 분지상 아미노산(류신, 이소류신, 발린)의 대사에 필요하고, 에너지 소모량과 상관 관계가 큰 물질로 알려져 있으며, 부족한 경우 초기에는 뚜렷한 증세를 나타내지 않다가 식욕부진, 체중감소, 무감각 등과 같은 정신적 증세, 과민성, 근육 무력증, 심장비대 등의 심혈관계 증세를 수반하며, 심각한 경우 신경계와 심혈관계의 장애를 나타내는 각기병(beriberi)이 유발된다.The vitamin B1 belongs to a water-soluble vitamin, is required for the metabolism of carbohydrates and branched amino acids (leucine, isoleucine, valine), and is known as a substance having a high correlation with energy consumption. It is accompanied by cardiovascular symptoms such as mental symptoms such as sluggishness, weight loss, and numbness, irritability, muscle weakness, and cardiac hypertrophy, and in severe cases, beriberi, which indicates neurological and cardiovascular disorders, is caused.
이때, 상기 비타민B1 염산염은 0.03 내지 0.3 중량%를 함유하는 것이 바람직한 바, 상기 비타민B1 염산염이 0.03 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 비타민B1 염산염이 0.3 중량%를 초과하면 중추 신경계와 관련된 부작용이 발생할 수도 있기 때문이다.At this time, the vitamin B1 hydrochloride preferably contains 0.03 to 0.3% by weight. If the vitamin B1 hydrochloride is less than 0.03% by weight, the expression of the above-mentioned effect is insufficient, and the vitamin B1 hydrochloride exceeds 0.3% by weight. This may be due to side effects associated with the central nervous system.
상기 비타민B2는 리보플라빈이라고도 하고, 수용성 비타민에 속하며, 체내의 에너지 대사에 중요한 물질로서, 리보플라빈 조효소가 여러가지 효소 반응에 관여하고, 다양한 종류의 리보플라빈 효소들이 탄소화물, 지방, 아미노산의 대사 경로에서 탈수소화반응, 수산화반응, 산화탈탄산반응, 이산소화반응, 산소의 과산화수소로의 환원 반응 등에 필수적으로 필요한 물질로 알려져 있다.The vitamin B2, also called riboflavin, belongs to a water-soluble vitamin, and is an important substance for energy metabolism in the body, riboflavin coenzymes are involved in various enzyme reactions, and various kinds of riboflavin enzymes are dehydrogenated in the metabolic pathways of carbohydrates, fats, and amino acids. It is known as an essential material for hydroxylation, deoxidation deoxidation, dioxygenation and reduction of oxygen to hydrogen peroxide.
또한, 상기 비타민B2가 결핍될 경우 구강염이 발생하고, 코나 입 주위의 안면이나 음낭, 외음부의 지루성 피부염, 안구충혈이나 조로성 백내장 및 빈혈 등이 발생함은 물론, 신체 활동 중에 쉽게 피곤을 느낀다.In addition, oral inflammation occurs when the vitamin B2 deficiency, facial or scrotum around the nose or mouth, seborrheic dermatitis of the vulva, ocular hyperemia or premature cataracts and anemia, as well as tired easily during physical activity.
이때, 상기 비타민B2는 0.03 내지 0.3 중량%를 함유하는 것이 바람직한 바, 상기 비타민B2가 0.03 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 비타민B2가 0.3 중량%를 초과하면 리보플라빈의 배설량이 증가하여 노란색 소변이 배설될 수 있기 때문이다.At this time, the vitamin B2 is preferably contained 0.03 to 0.3% by weight, the vitamin B2 is less than 0.03% by weight is insufficient expression of the above-described effect, when the vitamin B2 exceeds 0.3% by weight of the amount of riboflavin excreted This increases because yellow urine can be excreted.
상기 비타민B6 염산염은 화학식이 C8H11O3N·HCl로서, 물에 용해되기 쉬운 성질을 갖고 있다.The vitamin B6 hydrochloride has a chemical formula of C 8 H 11 O 3 N · HCl, and is easily soluble in water.
상기 비타민B6는 아미노산과 탄수화물의 대사, 헴합성, 신경전달물질의 합성, 면역 및 지질 대사에 관여하고, 호모시스테인의 이화작용 및 인산화효소 반응의 조효소로 작용하는 물질로 알려져 있으며, 부족시 지루성 피부염, 빈혈, 경련 및 습진 등이 발생한다.The vitamin B6 is involved in the metabolism of amino acids and carbohydrates, heme synthesis, the synthesis of neurotransmitters, immune and lipid metabolism, is known as a substance that acts as a coenzyme of catabolic and kinase reactions of homocysteine, seborrheic dermatitis, Anemia, cramps and eczema occur.
상기 비타민B6 염산염은 0.05 내지 0.5 중량%를 함유하는 것이 바람직한 바, 상기 비타민B6 염산염이 0.05 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 비타민B6 염산염이 0.5 중량%를 초과하면 신경 손상을 유발하여 손발쑤심, 비틀거림 등의 증상이 나타날 수 있기 때문이다.It is preferable that the vitamin B6 hydrochloride contains 0.05 to 0.5% by weight. If the vitamin B6 hydrochloride is less than 0.05% by weight, the expression of the above-mentioned effect is insufficient, and when the vitamin B6 hydrochloride exceeds 0.5% by weight, nerve damage This can cause symptoms such as hand hoofing and staggering.
상기 비타민C는 수용성 비타민에 해당하고 항산화 물질로서 신체를 활성산소로부터 보호하여 암, 동맥경화, 류머티즘 등을 예방하고, 면역체계를 강화시키며, 결합조직과 지지조직의 형성에 가담하여 피부와 잇몸의 건강을 보호해 주고, 기억력 유지와 인지 능력을 향상시켜 주는 물질로 알려져 있다.The vitamin C corresponds to a water-soluble vitamin and as an antioxidant, protects the body from free radicals, prevents cancer, arteriosclerosis, rheumatism, strengthens the immune system, and participates in the formation of connective and supportive tissues. It is known to protect health, maintain memory and improve cognitive ability.
상기 비타민C가 결핍될 경우 콜라겐 합성을 저해하여 괴혈병을 일으켜 잇몸 부종과 출혈 등이 나타나고, 만성 피로, 코피, 소화 장애, 우울증 등이 나타날 수 있으며, 골격 이상이 나타날 수도 있다.When the vitamin C deficiency inhibits collagen synthesis, it causes scurvy, swelling and bleeding of the gums, chronic fatigue, nosebleeds, digestive disorders, depression, and the like, and skeletal abnormalities.
상기 비타민C는 5 내지 15 중량%를 함유하는 것이 바람직한 바, 상기 비타민C가 5 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 비타민C가 15 중량%를 초과하면 철 흡수를 촉진하여 철 과다증이 유발될 수 있고, 속이 쓰리거나 설사를 일으킬 수 있는 문제가 있기 때문이다.The vitamin C is preferably contained 5 to 15% by weight, if the vitamin C is less than 5% by weight the expression of the above-mentioned effect is insufficient, if the vitamin C exceeds 15% by weight to promote iron absorption This can be caused by iron overdose and can cause heartburn or diarrhea.
상기 엽산은 비타민B군에 속하는 수용성 비타민으로서, 초록색 식물에 널리 분포되어 있고, 아미노산과 핵산의 합성에 필수적인 영양소이며, 특히 유전자를 만드는 핵산인 DNA 복제에 관여하는 효소의 조효소로 관여하여 세포 분열과 성장에 중요한 기능을 하는 물질이다.Folic acid is a water-soluble vitamin belonging to the vitamin B group, widely distributed in green plants, essential nutrients for the synthesis of amino acids and nucleic acids, in particular as a coenzyme of enzymes involved in DNA replication, a nucleic acid that makes genes. It is an important function of growth.
또한, 비타민 B12와 결합하여 성장 발달과 적혈구 생산의 기능을 하고, 뇌에서 신경전달물질인 노르아드레날린의 분비를 촉진시키며, 세포와 혈액 생성에 관여하는 물질이다.In addition, it combines with vitamin B12 to function as a growth and development of red blood cells, promote the secretion of the neurotransmitter noradrenaline in the brain, and is involved in the production of cells and blood.
상기 엽산이 결핍될 경우 빈혈을 초래하고 혈구에 거대적아구성 이상이 생길 수 있으며, 신경관 결함 등이 나타나게 된다.Deficiency of the folic acid may result in anemia and may result in megaloblastic abnormalities in blood cells, neural tube defects, and the like.
상기 엽산은 0.01 내지 0.1 중량%를 함유하는 것이 바람직한 바, 상기 엽산이 0.01 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 엽산이 0.1 중량%를 초과하면 비타민B12가 결핍될 수 있고, 신경 손상을 일으키며, 신장의 손상을 초래할 수 있기 때문이다.The folic acid preferably contains 0.01 to 0.1% by weight, if the folic acid is less than 0.01% by weight, the expression of the above-mentioned effect is insufficient, if the folic acid exceeds 0.1% by weight, vitamin B12 may be deficient, It causes nerve damage and can cause kidney damage.
상기 산화아연은 산소와 아연의 화합물로서 가벼운 백색 분말이며, 아연화라고도 불리는 물질로서, 신체의 정상적인 면역 기능과 세포 분열에 관여한다.The zinc oxide is a light white powder as a compound of oxygen and zinc and is also called zincation and is involved in the body's normal immune function and cell division.
아연이 결핍될 경우 면역 기능이 약화되어 감염이 쉽게 발생하고, 성장 장애 및 성적 성숙 지연 등의 현상이 발생할 수 있다.Zinc deficiency can weaken immune function and lead to infections, growth disorders and delayed sexual maturation.
상기 산화아연은 0.2 내지 2 중량%를 함유하는 것이 바람직하고, 상기 산화아연이 0.2 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 산화아연이 2 중량%를 초과하면 위점막을 자극하고, 구토, 설사 및 식욕부진 등의 부작용이 발생할 수 있기 때문이다.The zinc oxide preferably contains 0.2 to 2% by weight, when the zinc oxide is less than 0.2% by weight, the expression of the above-mentioned effect is insufficient, and when the zinc oxide exceeds 2% by weight, the gastric mucosa is stimulated. May cause side effects such as vomiting, diarrhea and anorexia.
상기 황산망간은 망간의 황산염으로서 무색의 조해성 고체이고, 화학식은 MnSO4이며, 물에 용해되는 물질로서, 뼈와 골격의 형성에 관여하고, 에너지의 이용에 필요하며, 유해산소로부터 세포를 보호하는 기능을 한다.The manganese sulfate is a colorless deliquescent solid as a sulfate of manganese, and the chemical formula is MnSO 4 , a substance soluble in water, involved in the formation of bone and skeleton, necessary for the use of energy, and protecting cells from harmful oxygen. Function
망간이 결핍될 경우 신체의 성장이 지연되고, 생식기능이 저하되며, 탄수화물과 지질의 대사에 변화를 초래하고, 특히 골격 발달을 저해한다.Lack of manganese delays the growth of the body, impairs reproductive function, alters the metabolism of carbohydrates and lipids, and in particular inhibits skeletal development.
상기 황산망간은 0.15 내지 1.5 중량%를 함유하는 것이 바람직하고, 상기 황산망간이 0.15 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 황산망간이 1.5 중량%를 초과하면 근육통, 피로, 떨림, 반사 능력 감소 등 신경 독성 증세가 나타날 수 있기 때문이다. The manganese sulfate preferably contains 0.15 to 1.5% by weight, the manganese sulfate is less than 0.15% by weight, the expression of the above-mentioned effect is insufficient, when the manganese sulfate exceeds 1.5% by weight myalgia, fatigue, tremor This may be due to neurotoxic symptoms such as decreased reflexes.
여기서, 상기 활성성분은 홍경천 추출물 1 내지 5%, 오양자 추출물 0.2 내지 2%, 가시오가피 추출물 0.15 내지 1.5%로 이루어진 군에서 선택된 1종 이상이 더 포함될 수 있다.Here, the active ingredient may be further included one or more selected from the group consisting of 1-5% honggyeongcheon extract, 0.2 ~ 2% of yangyang extract, 0.15 to 1.5% of thorny skin extract.
상기 홍경천 추출물은 참돌꽃이라 불리는 식물로부터 통상의 추출방법에 의하여 추출한 물질로서, 살리드로사이드(salidroside), 타이로솔(tyrosol) 및 배당체를 비롯하여 전분, 단백질, 지방, 아미노산, 당분, 플로본류 화합물, 미네랄 등을 풍부하게 포함하고 있다.The honggyeongcheon extract is a material extracted by a common extraction method from a plant called sedum flower, including starch, protein, fat, amino acid, sugar, flavone compounds, including salidroside, tyrosol and glycosides It contains abundant minerals.
이러한 홍경천 추출물은 인체의 신진대사를 왕성하게 하여 세포의 활력을 증가시켜 스트레스와 피로 개선에 도움을 주고, 혈액의 흐름을 개선해 주며, 혈액의 산소량을 증가시켜 두뇌의 활동을 증가시킨다고 알려져 있다. These extracts are known to boost the body's metabolism, increase the vitality of the cells, help improve stress and fatigue, improve blood flow, and increase the amount of oxygen in the blood to increase brain activity.
이때, 상기 홍경천 추출물은 1 내지 5 중량%를 함유하는 것이 바람직한 바, 상기 홍경천 추출물이 1 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 홍경천 추출물이 5 중량%를 초과하면 다른 성분하고의 균형이 깨지고 제조 원가가 상승하기 때문이다.At this time, the honggyeongcheon extract preferably contains 1 to 5% by weight, if the honggyeongcheon extract is less than 1% by weight the expression of the above-mentioned effect is insufficient, if the honggyeongcheon extract exceeds 5% by weight and other ingredients This is because the balance is broken and manufacturing costs rise.
상기 오양자 추출물은 오미자, 구기자, 복분자, 사상자 및 토사자 등의 오양자 식물들로부터 통상의 추출방법에 의하여 추출한 물질로서, 원기를 회복시키고 신체의 활력을 증강시키며, 혈액순환을 개선하고, 폴리페놀을 함유하여 항산화 작용을 증진시킨다.The yangja extract is a material extracted by conventional extraction methods from yangja plants such as Schisandra chinensis, gojijaja, bokbunja, casualties and earthenware, restores energy, enhances the vitality of the body, improves blood circulation, polyphenols Promotes antioxidant activity by containing
이때, 상기 오양자 추출물은 오미자, 구기자, 복분자, 사상자 및 토사자가 각각 동일한 중량비로 포함된 오양자 고형분 30%와, 덱스트린 70%를 배합하여 이루어진다.At this time, the quinilla extract is made by mixing 30% yangyang solid content and dextrin 70% each containing Schisandra chinensis, wolfberry, bokbunja, casualties and earthenware in the same weight ratio.
상기 오양자 추출물은 0.2 내지 2 중량%를 포함하는 것이 바람직한 바, 상기 오양자 추출물이 0.2 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 오양자 추출물이 2 중량%를 초과하면 다른 성분하고의 균형이 깨지고 제조 원가가 상승하기 때문이다.It is preferable that the quantum extract contains 0.2 to 2% by weight. If the quantum extract is less than 0.2% by weight, the expression of the above-mentioned effect is insufficient, and when the quantum extract exceeds 2% by weight, the other components This is because the balance of labor costs is broken and manufacturing costs rise.
상기 가시오가피 추출물은 가시오가피 식물로부터 통상의 추출방법에 의하여 추출한 물질로서, 신체기관의 전반적인 기능을 증대시켜 주고, 간 기능을 회복시켜 스트레스와 피로를 풀어주는 효과가 있는 것으로 알려져 있다.The prickly pear extract is a material extracted by a common extraction method from prickly pear plants, and is known to have an effect of increasing the overall function of body organs and restoring liver function to relieve stress and fatigue.
상기 가시오가피 추출물은 0.15 내지 1.5 중량%를 포함하는 것이 바람직한 바, 상기 가시오가피 추출물이 0.15 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 가시오가피 추출물이 1.5 중량%를 초과하면 다른 성분하고의 균형이 깨지고 제조 원가가 상승하기 때문이다.It is preferable that the barb extract contains 0.15 to 1.5% by weight. If the barb extract is less than 0.15% by weight, the expression of the above-mentioned effect is insufficient. This breaks down and manufacturing costs rise.
더불어, 상기 활성성분은 은행잎 추출물 0.5 내지 3%, 정제어유분말 0.05 내지 0.5%로 이루어진 군에서 선택된 1종 이상이 더 포함될 수 있다.In addition, the active ingredient may be further included one or more selected from the group consisting of ginkgo biloba extract 0.5 to 3%, purified fish oil powder 0.05 to 0.5%.
상기 은행잎 추출물은 은행나무의 은행잎으로부터 통상의 추출방법에 의하여 추출한 물질로서, 두뇌의 집중력과 기억력을 강화시키고, 정신을 맑게 해 주며, 혈액순환을 개선시켜주는 효과가 있는 것으로 알려져 있다.The ginkgo biloba extract is extracted from the ginkgo biloba of ginkgo biloba by a conventional extraction method, it is known to enhance the concentration and memory of the brain, to clear the mind, and to improve the blood circulation.
여기서, 상기 은행잎 추출물은 0.5 내지 3 중량%를 함유하는 것이 바람직한 바, 상기 은행잎 추출물이 0.5 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 은행잎 추출물이 3 중량%를 초과하면 피부 알레르기 등의 부작용이 발생할 수 있고, 제조 원가가 상승하기 때문이다.Here, the ginkgo biloba extract is preferably contained 0.5 to 3% by weight, the ginkgo biloba extract is less than 0.5% by weight is insufficient expression of the above-described effect, if the ginkgo biloba extract is more than 3% by weight skin allergy, etc. Side effects can occur and manufacturing costs rise.
상기 정제어유분말은 등푸른 생선의 기름을 착유하여 불순물을 제거한 후 정제하여 분말로 제조한 것으로, 유지 성분 뿐만 아니라 DHA, EPA 등의 고도불포화 지방산이 풍부하게 함유되어 있다.The refined fish oil powder is prepared by powdering and removing impurities by milking the oil of blue fish, and is rich in polyunsaturated fatty acids such as DHA and EPA as well as oils and fats.
상기 정제어유분말은 두뇌를 성장 및 발달시켜 기억력과 학습력 증진에 효능이 있고, 혈액순환 개선에 효과가 있는 물질로 잘 알려져 있다.The refined fish oil powder is known to be effective in improving memory and learning by growing and developing the brain, and is effective in improving blood circulation.
상기 정제어유분말은 0.05 내지 0.5 중량%를 함유하는 것이 바람직한 바, 상기 정제어유분말이 0.05 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 정제어유분말이 0.5 중량%를 초과하면 알레르기 부작용이 발생할 수 있기 때문이다.The refined fish oil powder preferably contains 0.05 to 0.5% by weight. If the refined fish oil powder is less than 0.05% by weight, expression of the above-mentioned effects is insufficient, and when the purified fish oil powder exceeds 0.5% by weight, allergic side effects This can happen.
이와 함께, 상기 활성성분은 원지 추출물 0.05 내지 0.5%, 황금 추출물 0.05 내지 0.5%로 이루어진 군에서 선택된 1종 이상이 더 포함되거나, 건조효모분말 0.15 내지 1.5%가 더 포함될 수 있다.Along with this, the active ingredient may further include one or more selected from the group consisting of 0.05 to 0.5% of the original extract, 0.05 to 0.5% of the golden extract, or 0.15 to 1.5% of the dry yeast powder.
상기 원지 추출물은 원지(polygala tenuifolia)의 뿌리에서 통상의 추출방법에 의하여 추출한 물질로서, 정신 안정 효과가 뛰어나고, 항산화 기능, 스트레스 방어 및 기억력 증진 효과가 있는 것으로 알려져 있다.The raw paper extract is a material extracted by the conventional extraction method from the root of the raw paper (polygala tenuifolia), it is known to have excellent mental stability effect, antioxidant function, stress defense and memory enhancement effect.
상기 원지 추출물은 0.05 내지 0.5 중량%를 함유하는 것이 바람직한 바, 상기 원지 추출물이 0.05 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 원지 추출물이 0.5 중량%를 초과하면 알레르기 부작용이 발생할 수 있기 때문이다.It is preferable that the base extract contains 0.05 to 0.5% by weight. If the base extract is less than 0.05% by weight, the expression of the above-mentioned effect is insufficient, and if the base extract exceeds 0.5% by weight, allergic side effects may occur. Because there is.
상기 황금 추출물은 황금(scutellaria laterifolia)의 뿌리에서 통상의 추출방법에 의하여 추출한 물질로서, 항산화기능, 스트레스 방어 효능이 있고, 항염증 및 항알레르기성 작용을 하는 것으로 알려져 있다.The golden extract is a material extracted by the conventional extraction method from the root of the golden (scutellaria laterifolia), it is known to have antioxidant function, stress defense effect, anti-inflammatory and anti-allergic action.
상기 황금 추출물은 0.05 내지 0.5 중량%를 함유하는 것이 바람직한 바, 상기 황금 추출물이 0.05 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 황금 추출물이 0.5 중량%를 초과하면 다른 성분하고의 균형이 깨지고 제조 원가가 상승하기 때문이다.It is preferable that the golden extract contains 0.05 to 0.5% by weight. If the golden extract is less than 0.05% by weight, the expression of the above-described effect is insufficient, and when the golden extract exceeds 0.5% by weight, the balance with other ingredients This breaks down and manufacturing costs rise.
상기 건조효모분말은 수분이 많은 효모가 부패되지 않고 저장할 수 있도록 하기 위하여 건조시킨 건조효모(dried yeast)의 분말로서, 비타민과 미네랄은 물론 미량원소까지 공급받을 수 있고, 소화작용과 신진대사를 촉진시키며, 성장기에 신진대사를 왕성하게 하여 발육을 촉진시키고, 뇌 기능을 향상시키는 것으로 알려져 있다.The dry yeast powder is a powder of dried yeast (dried yeast) to be stored so that the yeast with a lot of moisture does not decay, vitamins and minerals can be supplied as well as trace elements, promoting digestion and metabolism It is known to stimulate metabolism during growth and promote growth and improve brain function.
상기 건조효모분말은 0.15 내지 1.5 중량%를 함유하는 것이 바람직한 바, 상기 건조효모분말이 0.15 중량% 미만이면 상술된 효과의 발현이 부족하게 되고, 상기 건조효모분말이 1.5 중량%를 초과하면 복통과 설사 등의 증상이 발생할 수 있기 때문이다.Preferably, the dry yeast powder contains 0.15 to 1.5% by weight. If the dry yeast powder is less than 0.15% by weight, the expression of the above-described effects is insufficient, and when the dry yeast powder exceeds 1.5% by weight, the abdominal pain may occur. This is because symptoms such as diarrhea may occur.
상기 부형제로서, 결정셀룰로오스와 유당혼합분말 중에서 선택된 1종 또는 2종이 60 내지 80 중량%를 포함한다.As the excipient, one or two selected from crystalline cellulose and lactose mixed powder contains 60 to 80% by weight.
상기 결정셀룰로오스는 알약이나 캡슐의 형태를 이루기 위해 사용되는 첨가제로서, α-셀룰로오스를 무기산에 의해 부분적으로 해중합하여 정제한 것이고, 비섬유상 부분으로 구성되어 있으며, 유동성을 갖고 있다.The crystalline cellulose is an additive used to form a pill or capsule. The crystalline cellulose is partially depolymerized and purified by α-cellulose with an inorganic acid, is composed of a non-fibrous portion, and has fluidity.
상기 유당혼합분말은 유당 95 중량%와 덱스트린 5 중량%를 배합하여 제조된 분말로서, 알약이나 캡슐의 형태를 만드는데 사용된다.The lactose mixed powder is a powder prepared by mixing 95% by weight of lactose and 5% by weight of dextrin, and is used to form pills or capsules.
이때, 상기 부형제가 결정셀룰로오스와 유당혼합분말을 모두 포함하는 경우, 상기 결정셀룰로오스와 유당혼합분말의 혼합비가 중량 기준으로 1:0.4 내지 1:0.6인 것이 바람직하고, 더욱 바람직하게는 1:0.5인 것이 좋다. 이는 정제로의 압축 성형의 용이성과, 복용의 편의성을 고려한 것이다.In this case, when the excipient includes both crystalline cellulose and lactose mixed powder, the mixing ratio of the crystalline cellulose and lactose mixed powder is preferably 1: 0.4 to 1: 0.6 by weight, more preferably 1: 0.5. It is good. This takes into account the ease of compression molding into tablets and the convenience of taking.
상기 코팅제는 상기 활성성분이 열과 수분에 불안정하므로, 상기 활성성분과 부형제 등이 혼합되어 제조된 정제는 적절한 코팅제를 이용하여 외부에 코팅층을 형성함으로써 장시간의 경시 변화에도 안정성을 유지할 수 있다.Since the coating agent is unstable in heat and moisture, the tablet prepared by mixing the active ingredient and excipients can maintain stability even with a long time change by forming a coating layer on the outside using an appropriate coating agent.
이때, 상기 코팅제의 함량은 0.5 내지 5 중량%를 갖도록 하는 것이 바람직한데, 상기 코팅제의 함량이 0.5 중량% 미만이면 정제의 안정성을 충분히 확보할 수 없고, 상기 코팅제의 함량이 5 중량%를 초과하면 정제의 적절한 붕해 및 활성성분의 방출을 방해할 수 있기 때문이다.At this time, it is preferable that the content of the coating agent is 0.5 to 5% by weight. When the content of the coating agent is less than 0.5% by weight, the stability of the tablet cannot be sufficiently secured, and when the content of the coating agent is more than 5% by weight. As it may interfere with proper disintegration of the tablet and release of the active ingredient.
여기서, 상기 코팅제는 히드록시프로필메틸셀룰로오스, 피마자유, 프로필렌글리콜, 폴리에틸렌글리콜, 포비돈, 탈크, 탄산칼슘, 카르나우바납, 이산화규소, 메타아크릴산 공중합체 및 산화티탄으로 이루어진 군에서 선택된 1종 이상으로 이루어질 수 있다.Here, the coating agent is at least one selected from the group consisting of hydroxypropyl methyl cellulose, castor oil, propylene glycol, polyethylene glycol, povidone, talc, calcium carbonate, carnauba lead, silicon dioxide, methacrylic acid copolymer and titanium oxide Can be done.
상기 첨가제는 카르복시메틸셀룰로오스칼슘 0.5 내지 3%, 스테아린산마그네슘 0.5 내지 1.5%를 포함한다. 상기 카르복시메틸셀룰로오스칼슘 및 스테아린산마그네슘은 정제의 점착성 및 점도를 증가시키고 유화안정성을 증진시키며, 정제의 물성을 향상시키기 위하여 첨가한다.The additives include 0.5 to 3% of carboxymethyl cellulose calcium and 0.5 to 1.5% of magnesium stearate. The carboxymethyl cellulose calcium and magnesium stearate are added to increase the adhesiveness and viscosity of the tablet, to improve the emulsion stability, and to improve the physical properties of the tablet.
도 1에 도시된 바와 같이, 본 발명에 따른 수험생용 비타 하이브리드 정제의 제조 방법은 먼저 각 원료를 전자저울로 칭량하는 칭량 단계(S10 단계)를 수행한다.As shown in Figure 1, the method for producing a student vita hybrid tablet according to the present invention first performs a weighing step (S10 step) for weighing each raw material with an electronic balance.
상기 칭량 단계(S10 단계)는 규격 기준에 적합한 각 원료를 확인 구입한 후 품질 검사를 하며, 품질 검사가 끝난 각 원료를 미생물의 혼입 우려가 없는 원료칭량실에서 사용되는 양만큼 전자저울로 칭량한다.The weighing step (S10 step) checks and purchases each raw material conforming to the standard standards, and performs a quality inspection, and weighs each of the finished raw materials into electronic balances by the amount used in the raw material weighing chamber without fear of microbial incorporation. .
상기 칭량 단계(S10 단계)의 수행 후, 중량%로, 비타민A 혼합제 0.5 내지 5%, 비타민B1 염산염 0.03 내지 0.3%, 비타민B2 0.03 내지 0.3%, 비타민B6 염산염 0.05 내지 0.5%, 비타민C 5 내지 15%, 엽산 0.01 내지 0.1%, 산화아연 0.2 내지 2%, 황산망간 0.15 내지 1.5%을 포함한 활성성분과, 결정셀룰로오스와 유당혼합분말 중에서 선택된 1종 또는 2종이 60 내지 80%를 포함한 부형제와, 기타 첨가제를 혼합기에 투입한 후 20 ~ 40분 동안 15 ~ 30 RPM으로 혼합하여 혼합물을 만드는 혼합 단계(S20 단계)를 수행한다.After performing the weighing step (S10 step), in weight percent, vitamin A admixture 0.5 to 5%, vitamin B1 hydrochloride 0.03 to 0.3%, vitamin B2 0.03 to 0.3%, vitamin B6 hydrochloride 0.05 to 0.5%, vitamin C 5 to An excipient comprising 15%, 0.01 to 0.1% folic acid, 0.2 to 2% zinc oxide, 0.15 to 1.5% manganese sulfate, and 60 to 80% of one or two selected from crystalline cellulose and lactose mixed powder, After the other additives are added to the mixer, the mixture is mixed at 15 to 30 RPM for 20 to 40 minutes to perform a mixing step (step S20).
상기 혼합 단계(S20 단계)는 혼합 시간이 너무 짧거나 혼합속도가 낮으면 잘 혼합되지 않거나 혼합물의 점도가 낮아 후속 공정에 지장을 주고, 혼합 시간이 너무 길거나 혼합속도가 높으면 혼합 효과가 포화되므로, 혼합기에 투입한 후 20 ~ 40분 동안 15 ~ 30 RPM으로 혼합하여 혼합물을 만드는 것이 바람직하다.If the mixing step (S20 step) is too short or the mixing speed is not mixed well or the viscosity of the mixture is hindered in the subsequent process, if the mixing time is too long or the mixing speed is high, the mixing effect is saturated, It is preferable to make a mixture by mixing at 15 to 30 RPM for 20 to 40 minutes after adding to the mixer.
상기 혼합 단계(S20 단계)의 수행 후, 상기 혼합물을 자동 타정기를 이용하여 일정량으로 타정하는 타정 단계(S30 단계)를 수행한다.After performing the mixing step (step S20), the tableting step (S30 step) to tablet the mixture in a predetermined amount using an automatic tableting machine.
그리고, 상기 타정 단계(S30 단계)의 수행 후, 0.5 내지 5%의 코팅제를 주정알콜에 녹여서 코팅기제를 제조한 후 타정된 정제를 코팅기에서 코팅하는 코팅 단계(S40 단계)를 수행하여 본 발명에 따른 수험생용 비타 하이브리드 정제를 제조하는 것이다.
Then, after performing the tableting step (step S30), 0.5 to 5% of the coating agent is dissolved in alcohol alcohol to prepare a coating base, and then performing a coating step (S40 step) to coat the tablets on the coating machine in the present invention. It is to prepare a testa vita hybrid tablet according to.
[[ 실시예Example ]]
하기의 표 1에 기재된 각 원료 및 함량을 원료칭량실에서 전자저울로 칭량하고, 코팅제인 히드록시프로필메틸셀룰로오스 1.5 중량%를 제외한 나머지 칭량한 원료들을 혼합기에 투입하여 25분간 22rpm으로 혼합하여 혼합물을 생성하며, 생성된 혼합물을 자동타정기로 1정에 591mg씩 되도록 타정하였다.The raw materials and contents shown in Table 1 below were weighed with an electronic balance in a raw material weighing chamber, and the remaining raw materials except 1.5 wt% of hydroxypropylmethylcellulose as a coating agent were added to a mixer and mixed at 22 rpm for 25 minutes to mix the mixture. It was produced, and the resulting mixture was compressed into tablets 591mg per tablet with a tableting machine.
다음에, 1.5 중량%의 히드록시프로필메틸셀룰로오스를 주정알콜에 녹여서 코팅기제를 제조한 후 타정된 정제를 코팅기에서 코팅하여 1정에 600mg을 갖는 코팅된 정제를 제조하였다.
Next, 1.5 wt% of hydroxypropylmethylcellulose was dissolved in alcoholic alcohol to prepare a coating base, and the tableted tablets were coated on a coating machine to prepare coated tablets having 600 mg per tablet.
[표 1][Table 1]
그리고, 실시예 1 내지 5에서 제조된 본 발명에 따른 수험생용 비타 하이브리드 정제의 스트레스 및 피로의 회복도, 기억력 및 집중력의 향상도 등에 대하여 시험조사를 실시하였고, 그 결과를 평균하여 아래의 표 2에 나타내었다.In addition, a test investigation was performed on the degree of recovery of stress and fatigue, improvement of memory and concentration, and the like of the examinee vita hybrid tablets prepared in Examples 1 to 5, and the results were averaged. Shown in
상기 시험조사는 40인의 신체 건강한 10대 및 20대의 수험생에게 상기 실시예1 내지 5에 의해 제조된 수험생용 비타 하이브리드 정제를 1달(30일) 동안 매일 1회 1정씩 물과 함께 섭취하게 한 후 1달(30일) 뒤에 시험조사를 실시하였다.
The test was to take 40 healthy candidates of healthy body and teens intake with water 1 tablet once daily for 1 month (30 days) for 1 month (30 days) One month (30 days) later, the study was conducted.
[표 2][Table 2]
☞ 10점 : 매우 좋다, 5점 : 보통이다, 1점 : 매우 나쁘다
☞ 10 points: Very good, 5 points: Normal, 1 point: Very bad
상기 표 2에 나타난 바와 같이, 실시예 1 내지 5 모두 스트레스와 피로 회복도 및 집중력과 기억력 향상도가 우수한 것으로 확인되었고, 특히, 활성성분으로 비타민과 미네랄을 비롯하여 홍경천 추출물, 오양자 추출물, 가시오가피 추출물, 은행잎 추출물, 정제어유분말, 원지 추출물, 황금 추출물 및 건조효모분말 등이 함께 함유된 실시예 5에 대한 평가가 가장 우수하였다.As shown in Table 2, Examples 1 to 5 were found to be excellent in both stress and fatigue recovery, concentration and memory improvement, in particular, the active ingredients including vitamins and minerals, honggyeongcheon extract, yangyang extract, thorns Evaluation of Example 5 containing ginkgo biloba leaf extract, refined fish oil powder, raw paper extract, golden extract and dry yeast powder was the best.
따라서, 본 발명에 따라 제조된 수험생용 비타 하이브리드 정제는 각종 비타민과 미네랄 및 기능성 천연 추출물을 함유한 건강기능식품을 수험생에게 제공함으로써, 성장기의 수험생에게 부족한 비타민과 미네랄 등의 영양을 공급하여 균형있는 성장에 도움을 줄 뿐만 아니라, 두뇌의 혈행개선을 통해 뇌 유입 혈류량을 증가시켜 뇌 기능을 향상시켜 주고, 수험 스트레스로 인한 피로를 회복시켜 주어 신체의 피로를 개선시킴은 물론, 기억력 및 집중력을 강화시켜 학습력을 증진시킬 수 있음을 확인할 수 있었다.Accordingly, the vita hybrid tablet for examinees prepared according to the present invention provides the examinee with a health functional food containing various vitamins, minerals and functional natural extracts, thereby supplying nutrition such as vitamins and minerals insufficient to the examinee during the growing season It not only helps to grow, but also improves brain function by improving blood flow to the brain through improving the blood circulation of the brain. It was confirmed that the learning ability can be improved.
본 발명에서 상기 실시 형태는 하나의 예시로서 본 발명이 여기에 한정되는 것은 아니다. 본 발명의 특허청구범위에 기재된 기술적 사상과 실질적으로 동일한 구성을 갖고 동일한 작용효과를 이루는 것은 어떠한 것이라도 본 발명의 기술적 범위에 포함된다.
The present invention is not limited to the above-described embodiments. Anything having substantially the same constitution as the technical idea described in the claims of the present invention and achieving the same operational effect is included in the technical scope of the present invention.
Claims (9)
비타민A 혼합제 0.5 내지 5%, 비타민B1 염산염 0.03 내지 0.3%, 비타민B2 0.03 내지 0.3%, 비타민B6 염산염 0.05 내지 0.5%, 비타민C 5 내지 15%, 엽산 0.01 내지 0.1%, 산화아연 0.2 내지 2%, 황산망간 0.15 내지 1.5%을 포함한 활성성분;
결정셀룰로오스와 유당혼합분말 중에서 선택된 1종 또는 2종이 60 내지 80%를 포함한 부형제;
0.5 내지 5%를 갖는 코팅제; 및 기타 첨가제를 포함하는 수험생용 비타 하이브리드 정제.
By weight,
Vitamin A admixture 0.5 to 5%, vitamin B1 hydrochloride 0.03 to 0.3%, vitamin B2 0.03 to 0.3%, vitamin B6 hydrochloride 0.05 to 0.5%, vitamin C 5 to 15%, folic acid 0.01 to 0.1%, zinc oxide 0.2 to 2% Active ingredients including 0.15 to 1.5% manganese sulfate;
Excipients containing 60 to 80% of one or two selected from crystalline cellulose and lactose mixed powder;
Coating agents having 0.5 to 5%; And Vita hybrid tablets for test takers and other additives.
상기 활성성분은 홍경천 추출물 1 내지 5%, 오양자 추출물 0.2 내지 2%, 가시오가피 추출물 0.15 내지 1.5%로 이루어진 군에서 선택된 1종 이상이 더 포함되는 수험생용 비타 하이브리드 정제.
The method of claim 1,
The active ingredient is one or more selected from the group consisting of honggyeongcheon extract 1 to 5%, yangyang extract 0.2 to 2%, 0.15 to 1.5% thorn ogapi extract tablets for the examinee vita hybrid.
상기 활성성분은 은행잎 추출물 0.5 내지 3%, 정제어유분말 0.05 내지 0.5%로 이루어진 군에서 선택된 1종 이상이 더 포함되는 수험생용 비타 하이브리드 정제.
The method of claim 1,
The active ingredient is a veterinary vita hybrid tablet further comprises one or more selected from the group consisting of ginkgo biloba extract 0.5 to 3%, purified fish oil powder 0.05 to 0.5%.
상기 활성성분은 원지 추출물 0.05 내지 0.5%, 황금 추출물 0.05 내지 0.5%로 이루어진 군에서 선택된 1종 이상이 더 포함되는 수험생용 비타 하이브리드 정제.
The method of claim 1,
The active ingredient is Vita hybrid tablets for the examinee further comprises one or more selected from the group consisting of 0.05 ~ 0.5% of the original extract, 0.05 to 0.5% golden extract.
상기 활성성분은 건조효모분말 0.15 내지 1.5%를 더 포함하는 수험생용 비타 하이브리드 정제.
The method of claim 1,
The active ingredient is a vita hybrid tablet for examinees further comprising 0.15 to 1.5% dry yeast powder.
상기 부형제는 결정셀룰로오스와 유당혼합분말을 모두 포함하고,
상기 결정셀룰로오스와 유당혼합분말의 혼합비가 중량 기준으로 1:0.4 내지 1:0.6인 것을 특징으로 하는 수험생용 비타 하이브리드 정제.
The method of claim 1,
The excipient includes both crystalline cellulose and lactose mixed powder,
The vita hybrid tablet for examinees, characterized in that the mixing ratio of the crystalline cellulose and lactose mixed powder is 1: 0.4 to 1: 0.6 by weight.
상기 코팅제는 히드록시프로필메틸셀룰로오스, 피마자유, 프로필렌글리콜, 폴리에틸렌글리콜, 포비돈, 탈크, 탄산칼슘, 카르나우바납, 이산화규소, 메타아크릴산 공중합체 및 산화티탄으로 이루어진 군에서 선택된 1종 이상으로 이루어지는 수험생용 비타 하이브리드 정제.
The method of claim 1,
The coating agent comprises at least one selected from the group consisting of hydroxypropyl methyl cellulose, castor oil, propylene glycol, polyethylene glycol, povidone, talc, calcium carbonate, carnauba lead, silicon dioxide, methacrylic acid copolymer and titanium oxide Vita hybrid tablets for.
상기 첨가제는 카르복시메틸셀룰로오스칼슘 0.5 내지 3%, 스테아린산마그네슘 0.5 내지 1.5%를 포함하는 수험생용 비타 하이브리드 정제.
The method of claim 1,
The additive is a veterinary vita hybrid tablet containing 0.5 to 3% carboxymethyl cellulose calcium, 0.5 to 1.5% magnesium stearate.
중량%로, 비타민A 혼합제 0.5 내지 5%, 비타민B1 염산염 0.03 내지 0.3%, 비타민B2 0.03 내지 0.3%, 비타민B6 염산염 0.05 내지 0.5%, 비타민C 5 내지 15%, 엽산 0.01 내지 0.1%, 산화아연 0.2 내지 2%, 황산망간 0.15 내지 1.5%을 포함한 활성성분과, 결정셀룰로오스와 유당혼합분말 중에서 선택된 1종 또는 2종이 60 내지 80%를 포함한 부형제와, 기타 첨가제를 혼합기에 투입한 후 20 ~ 40분 동안 15 ~ 30 RPM으로 혼합하여 혼합물을 만드는 혼합 단계;
상기 혼합물을 자동 타정기를 이용하여 일정량으로 타정하는 타정 단계; 및
0.5 내지 5%의 코팅제를 주정알콜에 녹여서 코팅기제를 제조한 후 타정된 정제를 코팅기에서 코팅하는 코팅 단계;를 포함하는 수험생용 비타 하이브리드 정제의 제조 방법.
A weighing step of weighing each raw material with an electronic balance;
By weight%, Vitamin A admixture 0.5 to 5%, Vitamin B1 hydrochloride 0.03 to 0.3%, Vitamin B2 0.03 to 0.3%, Vitamin B6 hydrochloride 0.05 to 0.5%, Vitamin C 5 to 15%, Folic acid 0.01 to 0.1%, Zinc oxide The active ingredient containing 0.2 to 2%, manganese sulfate 0.15 to 1.5%, an excipient containing 60 to 80% of one or two selected from crystalline cellulose and lactose mixed powder, and other additives, 20 to 40 A mixing step of mixing at 15-30 RPM for minutes to make a mixture;
A tableting step of tableting the mixture in a predetermined amount using an automatic tableting machine; And
Method of preparing a student vita hybrid tablet comprising a; coating step of dissolving 0.5 to 5% of the coating agent in alcohol alcohol to prepare a coating base and then coating the tablet tablet in a coating machine.
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Cited By (3)
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CN105935145A (en) * | 2015-12-18 | 2016-09-14 | 重庆两江药物研发中心有限公司 | Fish oil and phytosterol compound tablet and preparation method thereof |
JP2017061576A (en) * | 2014-12-05 | 2017-03-30 | 大正製薬株式会社 | Solid composition |
CN114343057A (en) * | 2022-01-11 | 2022-04-15 | 山东迅达康兽药有限公司 | Feed additive for enriching blood and preparation method thereof |
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2012
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2017061576A (en) * | 2014-12-05 | 2017-03-30 | 大正製薬株式会社 | Solid composition |
CN105935145A (en) * | 2015-12-18 | 2016-09-14 | 重庆两江药物研发中心有限公司 | Fish oil and phytosterol compound tablet and preparation method thereof |
CN105935145B (en) * | 2015-12-18 | 2019-09-20 | 重庆两江药物研发中心有限公司 | A kind of fish oil phytosterol complex tablet and preparation method thereof |
CN114343057A (en) * | 2022-01-11 | 2022-04-15 | 山东迅达康兽药有限公司 | Feed additive for enriching blood and preparation method thereof |
CN114343057B (en) * | 2022-01-11 | 2023-08-29 | 山东迅达康兽药有限公司 | Feed additive for enriching blood and preparation method thereof |
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