CN107616506A - Brain-invigorating walnut oil capsule based on phosphatidylserine and preparation method thereof - Google Patents
Brain-invigorating walnut oil capsule based on phosphatidylserine and preparation method thereof Download PDFInfo
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- CN107616506A CN107616506A CN201710815156.9A CN201710815156A CN107616506A CN 107616506 A CN107616506 A CN 107616506A CN 201710815156 A CN201710815156 A CN 201710815156A CN 107616506 A CN107616506 A CN 107616506A
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Abstract
The invention provides a kind of brain-invigorating walnut oil capsule based on phosphatidylserine and preparation method thereof.With delaying nerve cell aging effect, auxiliary improving memory function.Composition includes vitamin B6：0.6g 0.9g, vitamin B12：0.0008g 0.12g, lutein：5g 7.5g, ginkgo biloba p.e：48g 72g, phosphatidylserine：40g 60g, lecithin：80g 120g, carotenoid：2.4g 3.6g, DHA algal oil：80g 120g, walnut oil：164g 246g, beeswax：20g‑30g.The present invention is nutritious, can effectively be easy to carry, convenient to take, can effectively improve memory function.
Description
Technical field
The present invention relates to a kind of health food, specifically a kind of brain-invigorating walnut oil capsule based on phosphatidylserine and its
Preparation method.
Background technology
Content of the phosphatidylserine in human brain is far above other positions, reaches 17.7%, the actually phosphatide in human body
It is in the brain that acyl serine, which has half,.Trace it to its cause also it is well understood that because phosphatidylserine is the important set of cell membrane
Into composition, and cranial nerve cell, due to there is cynapse, the area of film is greater than other cells, therefore it also will be understood that with the age
Increasing, the amount of phosphatidylserine is reduced, and be first subjected to influence is exactly that the group composition of cell membrane in cranial nerve cell reduces,
Cynapse will be shortened, and when shortening to the cynapse of two nerve cells can not be connected to together, just occur including memory disorders
Cerebral disturbance the problems such as.
The content of the invention
The invention aims to solve the above-mentioned problems of the prior art, so provide it is a kind of have delay nerve
The brain-invigorating walnut oil capsule based on phosphatidylserine and preparation method thereof of cell ageing effect, auxiliary improving memory function.
The purpose of the present invention is achieved through the following technical solutions：
A kind of brain-invigorating walnut oil capsule based on phosphatidylserine, including capsule-core, capsule skin, content composition in described capsule-core
Including vitamin B6：0.6g-0.9g, vitamin B12：0.0008g-0.12g, lutein：5g-7.5g ginkgo biloba p.e：
48g-72g, phosphatidylserine：40g-60g, lecithin：80g-120g, carotenoid：2.4g-3.6g, DHA algal oil：80g-
120g, walnut oil：164g-246g, beeswax：20g-30g；Described capsule skin composition includes gelatin：272g, glycerine：112.4g is pure
Change water：272g, burnt sugar coloring 13.6g；Weight identical capsule 1000 is made based on above composition altogether.
Content composition includes vitamin B6 in described capsule-core：0.749g, vitamin B12：0.001g, lutein：
6.25g ginkgo biloba p.e：60g, phosphatidylserine：50g, lecithin：100g, carotenoid：3.0g, DHA algal oil：
100g, walnut oil：155g, beeswax：25g；Described capsule skin composition includes gelatin：272g, glycerine：112.4g, purified water：
272g, burnt sugar coloring 13.6g；Weight identical capsule 1000 is made based on above composition altogether.
The preparation method of brain-invigorating walnut oil capsule based on phosphatidylserine, its step are：
Step 1: vitamin B6, vitamin B12, lutein, ginkgo biloba p.e, phosphatidylserine, lecithin are crossed 100
Eye mesh screen, required vitamin B6, vitamin B12, lutein, ginkgo biloba p.e, phosphatidyl silk ammonia are weighed according to formula ratio
Acid, lecithin, carotenoid, DHA algal oil, walnut oil, beeswax, gelatin, glycerine, purified water, burnt sugar coloring；
Step 2: by DHA algal oil, walnut oil input stainless steel material-compound tank, 75 DEG C are heated to, the beeswax of formula ratio is put into, treats
After beeswax dissolves completely, continue stirring 5 minutes, obtain oily wax mixture；Vitamin B6, vitamin B12 equal increments are mixed equal
After even, mixed powder A is obtained；Mixed powder B is obtained after mixed powder A and lutein are well mixed；By mixed powder B and the phosphatidyl of formula ratio
Serine, lecithin, carotenoid, ginkgo biloba p.e are well mixed, and obtain mixed powder C；Treat that oily wax mixture temperature reaches 45
DEG C when, by mixed powder C add material-compound tank in, stir 15 minutes, obtain always mix material；Total mixed material is crossed into 2 times colloid mills, each mistake
Stirred 15 minutes after complete colloid mill, obtain core contents, be evacuated to vacuum for -0.06 ~ 0.08mpa and core contents without
The state of bubble, pressurization discharging, is transferred in material storage tube, standby；
Step 3: weigh in the purified water inputization glue tank of formula ratio, by the glycerine of formula ratio, burnt sugar coloring inputization glue tank, together
Shi Kaidong agitating paddles, when temperature reaches 70 DEG C in change glue tank, the gelatin of formula ratio is put into, and continue to be heated to 75 DEG C, insulation
Stir about 1 hour, until gelatin all dissolves, obtain glue mixed material；By glue mixed material be evacuated to vacuum-
0.06- -0.08MPa, to glue bubble-free, deflated after 30 minutes；Glue after deflation is crossed into 80 mesh stainless steel mesh；Released
Glue is placed in insulation glue-storing barrel and stands more than 4 hours after filter, keeps 50-55 DEG C of glue, standby；
Step 4: capsule 's content, glue are pressed into soft capsule in full-automatic pellet press, rotating speed is about adjusted to about 2-3 revs/min
Clock, sprinkler body temperature are kept for 42 DEG C or so, and rubber thickness is 0.7mm-0.85mm, and loading amount is 0.5g/ grains, 60min or so verification one
Secondary, content content exists（1±5.0%）Within × 0.5g scopes, the control of pelleting room temperature is at 18-22 DEG C, relative humidity control
System is in 30-40%；The soft capsule suppressed through pellet press, because there is certain temperature, body is softer, needs cooling and shaping, and method is pressure
Good capsule and pill enters in sizing rotating cage, is shaped 4 hours, obtained with cold wind under conditions of 18-22 DEG C of temperature, relative humidity 30-40%
Sizing ball；
Wash in ball groove Step 5: the soft capsule after sizing is poured into, washed with 95% edible alcohol.Submerged with 95% edible alcohol soft
Capsule, the fat-soluble bur such as the oily wax on soft capsule surface is washed away, release ethanol washing lotion, drain, the soft capsule after washing is divided
It is to be dried in screen tray；Soft capsule after drying is put in dry pallet, under conditions of 24-28 DEG C, relative humidity 30-40%,
Aeration-drying more than 24 hours, gently capsule was turned over 1 time every 2 hours；Dried soft capsule is placed in lamp inspection machine, manually will be different
The unqualified balls such as shape ball, flat ball, thin-walled ball, cause ball not of uniform size are selected, and qualified soft capsule is to be packaged.
The beneficial effects of the invention are as follows：By using technical scheme, it is easy to carry, convenient to take, phosphatidyl
Serine can effectively improve memory function, and DHA can promote phosphatidylserine to absorb, unsaturated fat is contained in walnut oil
Acid, flavonoids, Polyphenols has certain effect to brain tonic, also comprehensive rich in other various nutriments beneficial to human body, effect.
Embodiment
The present invention is described in further detail below：The present embodiment enters under premised on technical solution of the present invention
Row is implemented, and gives detailed embodiment, but protection scope of the present invention is not limited to following embodiments.
As one embodiment of the present of invention, a kind of brain-invigorating walnut oil capsule based on phosphatidylserine, including capsule-core,
Capsule skin, content composition includes vitamin B6 in described capsule-core：0.6g-0.9g, vitamin B12：0.0008g-0.12g, leaf
Flavine：5g-7.5g ginkgo biloba p.e：48g-72g, phosphatidylserine：40g-60g, lecithin：80g-120g, class Hu trailing plants
Bu Su：2.4g-3.6g, DHA algal oil：80g-120g, walnut oil：164g-246g, beeswax：20g-30g；Described capsule skin is into subpackage
Include gelatin：272g, glycerine：112.4g, purified water：272g, burnt sugar coloring 13.6g；Weight identical is made based on above composition altogether
Capsule 1000.
Content composition includes vitamin B6 in described capsule-core：0.749g, vitamin B12：0.001g, lutein：
6.25g ginkgo biloba p.e：60g, phosphatidylserine：50g, lecithin：100g, carotenoid：3.0g, DHA algal oil：
100g, walnut oil：155g, beeswax：25g；Described capsule skin composition includes gelatin：272g, glycerine：112.4g, purified water：
272g, burnt sugar coloring 13.6g；Weight identical capsule 1000 is made based on above composition altogether.
The preparation method of brain-invigorating walnut oil capsule based on phosphatidylserine, its step are：
Step 1: vitamin B6, vitamin B12, lutein, ginkgo biloba p.e, phosphatidylserine, lecithin are crossed 100
Eye mesh screen, required vitamin B6, vitamin B12, lutein, ginkgo biloba p.e, phosphatidyl silk ammonia are weighed according to formula ratio
Acid, lecithin, carotenoid, DHA algal oil, walnut oil, beeswax, gelatin, glycerine, purified water, burnt sugar coloring；
Step 2: by DHA algal oil, walnut oil input stainless steel material-compound tank, 75 DEG C are heated to, the beeswax of formula ratio is put into, treats
After beeswax dissolves completely, continue stirring 5 minutes, obtain oily wax mixture；Vitamin B6, vitamin B12 equal increments are mixed equal
After even, mixed powder A is obtained；Mixed powder B is obtained after mixed powder A and lutein are well mixed；By mixed powder B and the phosphatidyl of formula ratio
Serine, lecithin, carotenoid, ginkgo biloba p.e are well mixed, and obtain mixed powder C；Treat that oily wax mixture temperature reaches 45
DEG C when, by mixed powder C add material-compound tank in, stir 15 minutes, obtain always mix material；Total mixed material is crossed into 2 times colloid mills, each mistake
Stirred 15 minutes after complete colloid mill, obtain core contents, be evacuated to vacuum for -0.06 ~ 0.08mpa and core contents without
The state of bubble, pressurization discharging, is transferred in material storage tube, standby；
Step 3: weigh in the purified water inputization glue tank of formula ratio, by the glycerine of formula ratio, burnt sugar coloring inputization glue tank, together
Shi Kaidong agitating paddles, when temperature reaches 70 DEG C in change glue tank, the gelatin of formula ratio is put into, and continue to be heated to 75 DEG C, insulation
Stir about 1 hour, until gelatin all dissolves, obtain glue mixed material；By glue mixed material be evacuated to vacuum-
0.06- -0.08MPa, to glue bubble-free, deflated after 30 minutes；Glue after deflation is crossed into 80 mesh stainless steel mesh；Released
Glue is placed in insulation glue-storing barrel and stands more than 4 hours after filter, keeps 50-55 DEG C of glue, standby；
Step 4: capsule 's content, glue are pressed into soft capsule in full-automatic pellet press, rotating speed is about adjusted to about 2-3 revs/min
Clock, sprinkler body temperature are kept for 42 DEG C or so, and rubber thickness is 0.7mm-0.85mm, and loading amount is 0.5g/ grains, 60min or so verification one
Secondary, content content exists（1±5.0%）Within × 0.5g scopes, the control of pelleting room temperature is at 18-22 DEG C, relative humidity control
System is in 30-40%；The soft capsule suppressed through pellet press, because there is certain temperature, body is softer, needs cooling and shaping, and method is pressure
Good capsule and pill enters in sizing rotating cage, is shaped 4 hours, obtained with cold wind under conditions of 18-22 DEG C of temperature, relative humidity 30-40%
Sizing ball；
Wash in ball groove Step 5: the soft capsule after sizing is poured into, washed with 95% edible alcohol.Submerged with 95% edible alcohol soft
Capsule, the fat-soluble bur such as the oily wax on soft capsule surface is washed away, release ethanol washing lotion, drain, the soft capsule after washing is divided
It is to be dried in screen tray；Soft capsule after drying is put in dry pallet, under conditions of 24-28 DEG C, relative humidity 30-40%,
Aeration-drying more than 24 hours, gently capsule was turned over 1 time every 2 hours；Dried soft capsule is placed in lamp inspection machine, manually will be different
The unqualified balls such as shape ball, flat ball, thin-walled ball, cause ball not of uniform size are selected, and qualified soft capsule is to be packaged.
Preferable in above-described embodiment, content composition includes vitamin B6 in described capsule-core：0.749g, vitamin
B12：0.001g, lutein：6.25g ginkgo biloba p.e：60g, phosphatidylserine：50g, lecithin：100g, carotenoids
Element：3.0g, DHA algal oil：100g, walnut oil：155g, beeswax：25g；Described capsule skin composition includes gelatin：272g, glycerine：
112.4g, purified water：272g, burnt sugar coloring 13.6g；Weight identical capsule 1000 is made based on above composition altogether.
In the present invention, vitamin B6：Vitamin B6 is that PLP, PMP, PN must be by non-specificity in small intestinal lumen in food
Phosphorus solution enzyme (nospecific phosphoh Ydrolase) decomposed P LP, PMP PL, PM.Absorpting form is PL, PM and PN.
In anthroposcopy, the people of starvation is given with PN, PL, PM, 0.5 ~ 3h peaks after PN is given, during dosage small (0.5 ~ 4mg),
It is horizontal when plasma vitamin B6 levels return to approximate hungry again after 3 ~ 5h, take that plasma vitamin B6 after PL is horizontal and urine in
PA rises are very fast, but PM Absorption And Metabolisms are all slow compared with PN, PL.And when taking in PLP dosage big (such as 10mg), plasma vitamin
B6 and PLP continues to rise in 24h, maintains on high level, is phosphoric acid without PN in brain section and separation choroid plexus
Compound, choroid plexus are places of the transport PN from blood to cerebrospinal fluid, Vitamin B6 deficiency animal (rat) PL kinases
Decline, in the feed rats'liver of 5 weeks, PL livers kinases declines 50% and only declines 14% in brain.This also illustrates vitamin B6 to nerve
The importance of system, there is the function of improving memory.
Vitamin B12：Vitamin B12 is also known as cobalamin or cyanogen cobalt element, is a kind of to be made up of the porphyrins containing cobalt
B family vitamin, major function：1. promote development and the maturation of red blood cell, human body hematopoietic function is in normal condition, prevent
Pernicious anaemia；Safeguard nervous system health；2. exist in the form of coenzyme, the utilization rate of folic acid can be increased, promote carbon aquation
The metabolism of compound, fat and protein；3. there is activated amino acid and promote the biosynthesis of nucleic acid, albumen can be promoted
The synthesis of matter, it plays an important role to growing for infant.4. fat metabolism acid, makes fat, carbohydrate, protein
Suitably used by body；5. eliminate and have the fidgets, focus on, enhancing memory and the sense of equilibrium；6. it is that nervous function is good for
Complete indispensable vitamin, participates in a kind of formation of lipoprotein in nerve fiber, first, folic acid utilization rate is improved, with folic acid one
Play synthesis methionine（Synthesized by homocysteine）And choline, it is first that cyanocobalamin Shen base is synthesized during producing purine and pyrimidine
Material such as methylcobalamin and actimide are driven, participates in the methylation procedure of many important compounds, second, safeguarding the generation of neural myelin
Thank and function.Be deficient in vitamin B12 when, neurological disorder, spinal cord degeneration can be caused, and serious mental symptom can be caused.Dimension life
Plain B12, which lacks, can cause peripheral neuritis.The Early manifestation that child lacks vitamin B12 is abnormal feeling, has a dull expression on one's face, reacted
It is blunt, finally result in anaemia.Third, promote development and the maturation of red blood cell.It is auxiliary that methylmalonyl CoA is changed into succinyl
Enzyme A, participates in tricarboxylic acid cycle, and wherein succinyl-coenzyme A is relevant with the synthesis of ferroheme.Fourth, vitamin B12 also participates in deoxidation
Nucleic acid（DNA）Synthesis, the metabolism of fat, carbohydrate and protein, increase the synthesis of nucleic acid and protein.
Lutein：Lutein, alias carotenoid, carotenol, Lutein, core yellow body, marigold florigen and plant
Thing lutein etc., English entitled Lutein, molecular formula C40H56O2, relative molecular weight 568.85.Orange-yellow powder, pulpous state
Or liquid, it is not soluble in water, it is dissolved in the organic solvents such as hexane.Natural carotenol is a kind of excellent antioxidant, can be resisted free
Base causes cell and organ damage in human body, so as to prevent cardiovascula arteriosclerosis, coronary heart disease and the tumour of body aging initiation
Disease etc..Lutein and zeaxanthin are only 2 Carotenoids in eyes, prevent senile eyeball retina macular area disease
Visual impairment caused by change and the unique function that blindness is lutein.
Ginkgo biloba p.e：Ginkgo biloba p.e can play antioxygen in brain, eyeball retina and cardiovascular system
Change characteristic, its antioxidation in brain and central nervous system potentially contributes to prevent the cerebral function caused by the age
Decline, there is fabulous tonic effect to nervous system.Hundreds of secondary scientific researches comprising patients up to ten thousand confirm that ginkgo leaf extracts
The effect of thing to including cerebral blood flow deficiency and gerontal patient intelelectual deterioration including problems effect.Ginkgo is to many
The possibility symptom of aging has good effect.
Walnut oil：Vegetal Ω -3, Ω -6 aliphatic acid series contents are that human body must fat up to more than 67% in walnut oil
Fat acid, human body itself can not synthesize, it is necessary to pass through food intake.Alpha-linolenic acid and linoleic acid are a- leukotrienes, and r- leukotrienes is
Brain cell activity key element, ratio is close to 1:6 are easy to absorb, and DHA and ARA can be separately converted in infants；Especially leukotrienes
Healthy development to the brain of fetus and baby, retina, skin and renal function is particularly significant, meanwhile, the phosphatide in walnut oil
Rich content, cytoactive can be increased, memory and intellectual level can be improved, be important cerebrum tonifying element, and infant brain god
Composition key component pituitary through nutrition trace element zincs, manganese etc. necessary to being developed with visual performance, plant source
The property aliphatic acid of Ω -3 will not be converted into EPA, and natural leukotrienes and vitamin A are rich in walnut oil, both nutrients to regarding
The most important of development of nethike embrane prevents yctalopia and hypopsia, contributes to the treatment to a variety of eye illnesses, while rich in walnut oil
The vitamin E contained, and the various trace elements that human body needs；
Lecithin：Main component in lecithin is that phosphatidyl choline can form acetylcholine and phosphatidylserine and have collaboration
Effect；
DHA algal oil：DHA algal oil extracts from marine microalgae, the transmission without food chain, relatively safer, and its EPA content is very
Low, DHA is nervous system cell growth and a kind of essential element maintained, is the important composition aliphatic acid of brain and retina,
Content is up to 20% in human brain cortex, and most people think that fish is exactly DHA main source, and the fact is, the institute of fish
It is to have eaten the marine alga rich in DHA because of fish to contain DHA, and the DHA in marine alga is transmitted by food chain and just tired out in fish body
Accumulate, therefore algae DHA is not only more direct, nor the fishy smell of fish oil is had, DHA algal oil extracts from marine microalgae, not
Transmission through food chain, relatively safer, its EPA content is very low, meanwhile, DHA also have can promote phosphatidylserine
The effect of absorption；For DHA as a kind of essential fatty acid, it is more notable that it strengthens the effects such as memory and thinking ability, raising intelligence,
Population epidemiology research finds, the Psychological Endurance of the high people of internal DHA content is relatively strong, mental development index also high big
In Cerebral cortex, DHA is the Main Ingredients and Appearance of nerve conduction cell, is also the Main Ingredients and Appearance that cell membrane is formed, most DHA will not
Digested by gastric juice, and be directly entered blood, by absorbed organs such as liver or brains, and EPA and linolenic acid are not absorbed, main
It is due to that DHA can enter brain cell via blood-brain barrier to want reason, and is both the EPA and linolenic acid for belonging to unrighted acid
But can not be absorbed by blood-brain barrier by brain.
Phosphatidylserine：Phosphatidylserine（PS）Also known as serinephosphatide, diacylglycerol acyl phosphoserine, is present
On the inside of cell membrane, the metabolic activity of cell is participated in.Research shows, in different cells, PS content is also different.
Table 1：Phosphatidylserine（PS）Content in human body Different Organs
Table 1 is visible, and phosphatidylserine largely exists in cranial nerve cell, is referred to as " nutrient of brain ", and the god of human brain
About 50% is phosphatide in dry weight through cell membrane.
Other research shows, phosphatidylserine and other a variety of phosphatide in human brain（Phosphatidyl choline PC, phosphatidyl
Monoethanolamine PE etc.）Started to reduce with the growth at age before and after 30 years old.
Contents of the PS in human brain is far above other positions, reaches 17.7%, and the actually phosphatidylserine in human body has
Half is in the brain, to trace it to its cause also it is well understood that because phosphatidylserine is the important composition composition of cell membrane, and brain
For nerve cell due to there is cynapse, the area of film is greater than other cells.Therefore it also will be understood that with advancing age, phosphatidyl
The amount of serine is reduced, and be first subjected to influence is exactly cranial nerve cell --- and the group composition of-cell membrane reduces, and cynapse will
Shorten, when shortening to the cynapse of two nerve cells can not be connected to together, the brain function including memory disorders just occurs
Obstacle.
With the increase at age, the decline of the elderly's cognitive ability is medically referred to as age related cognitive decline
（ARCD）.Many people at 40 to five ten years old (or even some people were at 30 years old or so), although clinical examination is healthy, brain
Agility not as in the past.They easily forget eyes, the position of key, it is difficult to remember other people name or matching name and face
Hole, Highlights in book are just have forgotten in a few minutes after reading.It is estimated that about 40% there is ARCD between the people of 50-59 year
Sign, people's ratio of 60-69 year rise to 50%, will be influenceed to most people at 80 years old by ARCD.
Zoopery proves：PS is taken in the repetition of senile dementia rat can improve passive and active avoidance task acquisition and guarantor
Hold.Continuous P S administrations can reduce the quantity of old epilepsy formula electroencephalogram burst, improve avoidance conditioning and recover spontaneous alternation.
Another change of Animal Aging is that dendron and dendritic spines number are reduced in brain.Studies have shown that Long-term Oral PS, PI
This process can be delayed, illustrate that phosphatidylserine can influence cynapse and the metabolism of cell membrane, influence the maturation of dendritic cells.
In a word, the experiment carried out in aged rats shows：Phosphatidylserine is either injected intraperitoneally or is administered orally
The degree with behavior caused by aging, physiology, neurotransmitter and morphological change can be reduced.
Clinical trial for 36-60 year people shows, is taking phosphatidylserine 300mg/ days, after 3 months, subject
Linguistic memories ability have a significant raising, wherein older's effect is more significant.
The present invention uses soft gelatin capsules, there is excellent isolation features and good visual effect, and bioavilability
High, the features such as content is accurate, uniformity is good, good appearance, be auxiliary improvement of memory, suitable population to be grown up, be easy to by soft capsule
Carry, it is convenient to take.While residential use daily suitable for consumer, it is more suitable for people and is being away on a vacation, is travelling and field
Eaten during work, and soft capsule absorbs fast, absorption completely in vivo, bioavilability is high.
The foregoing is only a preferred embodiment of the present invention, these embodiments are all based on the present invention
Different implementations under general idea, and protection scope of the present invention is not limited thereto, it is any to be familiar with the art
Technical staff the invention discloses technical scope in, the change or replacement that can readily occur in, should all cover the present invention's
Within protection domain, therefore, protection scope of the present invention should be defined by the protection domain of claims.
Claims (3)
1. a kind of brain-invigorating walnut oil capsule based on phosphatidylserine, including capsule-core, capsule skin, it is characterised in that described capsule
Content composition includes vitamin B6 in core：0.6g-0.9g, vitamin B12：0.0008g-0.12g, lutein：5g-7.5g,
Ginkgo biloba p.e：48g-72g, phosphatidylserine：40g-60g, lecithin：80g-120g, carotenoid：2.4g-
3.6g, DHA algal oil：80g-120g, walnut oil：164g-246g, beeswax：20g-30g；Described capsule skin composition includes gelatin：
272g, glycerine：112.4g, purified water：272g, burnt sugar coloring 13.6g；Weight identical capsule 1000 is made based on above composition altogether
Grain.
2. the brain-invigorating walnut oil capsule according to claim 1 based on phosphatidylserine, it is characterised in that described capsule
Content composition includes vitamin B6 in core：0.749g, vitamin B12：0.001g, lutein：6.25g ginkgo biloba p.e：
60g, phosphatidylserine：50g, lecithin：100g, carotenoid：3.0g, DHA algal oil：100g, walnut oil：155g, honeybee
Wax：25g；Described capsule skin composition includes gelatin：272g, glycerine：112.4g, purified water：272g, burnt sugar coloring 13.6g；Based on
Weight identical capsule 1000 is made in upper composition altogether.
3. the preparation method of the brain-invigorating walnut oil capsule according to claim 1 based on phosphatidylserine, its step are：
Step 1: vitamin B6, vitamin B12, lutein, ginkgo biloba p.e, phosphatidylserine, lecithin are crossed 100
Eye mesh screen, required vitamin B6, vitamin B12, lutein, ginkgo biloba p.e, phosphatidyl silk ammonia are weighed according to formula ratio
Acid, lecithin, carotenoid, DHA algal oil, walnut oil, beeswax, gelatin, glycerine, purified water, burnt sugar coloring；
Step 2: by DHA algal oil, walnut oil input stainless steel material-compound tank, 75 DEG C are heated to, the beeswax of formula ratio is put into, treats
After beeswax dissolves completely, continue stirring 5 minutes, obtain oily wax mixture；Vitamin B6, vitamin B12 equal increments are mixed equal
After even, mixed powder A is obtained；Mixed powder B is obtained after mixed powder A and lutein are well mixed；By mixed powder B and the phosphatidyl of formula ratio
Serine, lecithin, carotenoid, ginkgo biloba p.e are well mixed, and obtain mixed powder C；Treat that oily wax mixture temperature reaches 45
DEG C when, by mixed powder C add material-compound tank in, stir 15 minutes, obtain always mix material；Total mixed material is crossed into 2 times colloid mills, each mistake
Stirred 15 minutes after complete colloid mill, obtain core contents, be evacuated to vacuum for -0.06 ~ 0.08mpa and core contents without
The state of bubble, pressurization discharging, is transferred in material storage tube, standby；
Step 3: weigh in the purified water inputization glue tank of formula ratio, by the glycerine of formula ratio, burnt sugar coloring inputization glue tank, together
Shi Kaidong agitating paddles, when temperature reaches 70 DEG C in change glue tank, the gelatin of formula ratio is put into, and continue to be heated to 75 DEG C, insulation
Stir about 1 hour, until gelatin all dissolves, obtain glue mixed material；By glue mixed material be evacuated to vacuum-
0.06- -0.08MPa, to glue bubble-free, deflated after 30 minutes；Glue after deflation is crossed into 80 mesh stainless steel mesh；Released
Glue is placed in insulation glue-storing barrel and stands more than 4 hours after filter, keeps 50-55 DEG C of glue, standby；
Step 4: capsule 's content, glue are pressed into soft capsule in full-automatic pellet press, rotating speed is about adjusted to about 2-3 revs/min
Clock, sprinkler body temperature are kept for 42 DEG C or so, and rubber thickness is 0.7mm-0.85mm, and loading amount is 0.5g/ grains, 60min or so verification one
Secondary, content content exists（1±5.0%）Within × 0.5g scopes, the control of pelleting room temperature is at 18-22 DEG C, relative humidity control
System is in 30-40%；The soft capsule suppressed through pellet press, because there is certain temperature, body is softer, needs cooling and shaping, and method is pressure
Good capsule and pill enters in sizing rotating cage, is shaped 4 hours, obtained with cold wind under conditions of 18-22 DEG C of temperature, relative humidity 30-40%
Sizing ball；
Wash in ball groove Step 5: the soft capsule after sizing is poured into, washed with 95% edible alcohol；
Soft capsule is submerged with 95% edible alcohol, washes away the fat-soluble bur such as the oily wax on soft capsule surface, releases ethanol washing lotion,
Drain, the soft capsule after washing is divided in screen tray, to be dried；Soft capsule after drying is put in dry pallet, at 24-28 DEG C,
Under conditions of relative humidity 30-40%, aeration-drying more than 24 hours, gently capsule was turned over 1 time every 2 hours；By dried flexible glue
Capsule is placed in lamp inspection machine, is manually selected the unqualified balls such as special-shaped ball, flat ball, thin-walled ball, cause ball not of uniform size, qualified soft capsule
It is to be packaged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710815156.9A CN107616506A (en) | 2017-09-12 | 2017-09-12 | Brain-invigorating walnut oil capsule based on phosphatidylserine and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109527124A (en) * | 2019-01-24 | 2019-03-29 | 山西潞安石圪节智华生物科技有限公司 | A kind of peony seed oil preparation and preparation method thereof improving memory |
| CN110692893A (en) * | 2019-11-12 | 2020-01-17 | 南通厚元生物科技有限公司 | Preparation method of solid beverage containing phosphatidylserine and omega-3 fatty acid |
| CN113876831A (en) * | 2021-10-12 | 2022-01-04 | 四川逢春制药有限公司 | Composition for improving memory and reducing blood fat, preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618029A (en) * | 2009-07-19 | 2010-01-06 | 梁木鸿 | Soft capsule with function of improving memory and preparation technology thereof |
| CN102960738A (en) * | 2012-12-20 | 2013-03-13 | 汤臣倍健股份有限公司 | Bilberry and lutein soft capsule and preparation method thereof |
| CN103238840A (en) * | 2013-05-16 | 2013-08-14 | 汤臣倍健股份有限公司 | Ginkgo biloba extract and fish oil soft capsule and preparation method thereof |
| CN104258241A (en) * | 2014-09-26 | 2015-01-07 | 洛阳华以生物工程有限公司 | Health product for preventing and treating senile dementia |
| CN105287430A (en) * | 2015-12-01 | 2016-02-03 | 广州市富诺生物科技有限公司 | Algae oil soft capsule and preparation method thereof |
| CN106562937A (en) * | 2016-10-20 | 2017-04-19 | 山东健康源生物工程有限公司 | Coenzyme Q10 soft capsule and preparation method thereof |
-
2017
- 2017-09-12 CN CN201710815156.9A patent/CN107616506A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618029A (en) * | 2009-07-19 | 2010-01-06 | 梁木鸿 | Soft capsule with function of improving memory and preparation technology thereof |
| CN102960738A (en) * | 2012-12-20 | 2013-03-13 | 汤臣倍健股份有限公司 | Bilberry and lutein soft capsule and preparation method thereof |
| CN103238840A (en) * | 2013-05-16 | 2013-08-14 | 汤臣倍健股份有限公司 | Ginkgo biloba extract and fish oil soft capsule and preparation method thereof |
| CN104258241A (en) * | 2014-09-26 | 2015-01-07 | 洛阳华以生物工程有限公司 | Health product for preventing and treating senile dementia |
| CN105287430A (en) * | 2015-12-01 | 2016-02-03 | 广州市富诺生物科技有限公司 | Algae oil soft capsule and preparation method thereof |
| CN106562937A (en) * | 2016-10-20 | 2017-04-19 | 山东健康源生物工程有限公司 | Coenzyme Q10 soft capsule and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109527124A (en) * | 2019-01-24 | 2019-03-29 | 山西潞安石圪节智华生物科技有限公司 | A kind of peony seed oil preparation and preparation method thereof improving memory |
| CN110692893A (en) * | 2019-11-12 | 2020-01-17 | 南通厚元生物科技有限公司 | Preparation method of solid beverage containing phosphatidylserine and omega-3 fatty acid |
| CN113876831A (en) * | 2021-10-12 | 2022-01-04 | 四川逢春制药有限公司 | Composition for improving memory and reducing blood fat, preparation method and application thereof |
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