CN111602820A - Drop containing vitamin A and vitamin D and its preparation method - Google Patents
Drop containing vitamin A and vitamin D and its preparation method Download PDFInfo
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- CN111602820A CN111602820A CN202010470753.4A CN202010470753A CN111602820A CN 111602820 A CN111602820 A CN 111602820A CN 202010470753 A CN202010470753 A CN 202010470753A CN 111602820 A CN111602820 A CN 111602820A
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- vitamin
- oil
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- drops
- drop
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- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title claims abstract description 161
- 229930003316 Vitamin D Natural products 0.000 title claims abstract description 159
- 235000019166 vitamin D Nutrition 0.000 title claims abstract description 159
- 239000011710 vitamin D Substances 0.000 title claims abstract description 159
- 150000003710 vitamin D derivatives Chemical class 0.000 title claims abstract description 159
- 229940046008 vitamin d Drugs 0.000 title claims abstract description 159
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 title claims abstract description 137
- 229940045997 vitamin a Drugs 0.000 title claims abstract description 117
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 title claims abstract description 102
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 title claims abstract description 101
- 235000019155 vitamin A Nutrition 0.000 title claims abstract description 101
- 239000011719 vitamin A Substances 0.000 title claims abstract description 101
- 238000002360 preparation method Methods 0.000 title claims abstract description 47
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 111
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 50
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 50
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 50
- 239000011709 vitamin E Substances 0.000 claims abstract description 50
- 229940046009 vitamin E Drugs 0.000 claims abstract description 50
- 239000003921 oil Substances 0.000 claims abstract description 44
- 235000019198 oils Nutrition 0.000 claims abstract description 44
- 239000002285 corn oil Substances 0.000 claims abstract description 33
- 235000005687 corn oil Nutrition 0.000 claims abstract description 32
- 230000001954 sterilising effect Effects 0.000 claims abstract description 32
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims abstract description 30
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 25
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 25
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 25
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims abstract description 24
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 24
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 23
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229960000342 retinol acetate Drugs 0.000 claims abstract description 16
- 235000019173 retinyl acetate Nutrition 0.000 claims abstract description 16
- 239000011770 retinyl acetate Substances 0.000 claims abstract description 16
- 239000011647 vitamin D3 Substances 0.000 claims abstract description 16
- 239000008157 edible vegetable oil Substances 0.000 claims abstract description 12
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 239000011259 mixed solution Substances 0.000 claims description 32
- 238000003756 stirring Methods 0.000 claims description 26
- 238000010438 heat treatment Methods 0.000 claims description 24
- 238000004806 packaging method and process Methods 0.000 claims description 18
- 238000001816 cooling Methods 0.000 claims description 17
- 238000001914 filtration Methods 0.000 claims description 17
- 239000004744 fabric Substances 0.000 claims description 16
- 239000000706 filtrate Substances 0.000 claims description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 14
- 239000000047 product Substances 0.000 claims description 13
- 229930003799 tocopherol Natural products 0.000 claims description 13
- 239000011732 tocopherol Substances 0.000 claims description 13
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 12
- 239000008158 vegetable oil Substances 0.000 claims description 12
- 150000003904 phospholipids Chemical group 0.000 claims description 11
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 9
- 235000013734 beta-carotene Nutrition 0.000 claims description 9
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 9
- 239000011648 beta-carotene Substances 0.000 claims description 9
- 229960002747 betacarotene Drugs 0.000 claims description 9
- 239000004006 olive oil Substances 0.000 claims description 9
- 235000008390 olive oil Nutrition 0.000 claims description 9
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 9
- 238000011049 filling Methods 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 8
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 7
- 229930003268 Vitamin C Natural products 0.000 claims description 7
- 235000019154 vitamin C Nutrition 0.000 claims description 7
- 239000011718 vitamin C Substances 0.000 claims description 7
- 239000003549 soybean oil Substances 0.000 claims description 6
- 235000012424 soybean oil Nutrition 0.000 claims description 6
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 5
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims description 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 3
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 235000019149 tocopherols Nutrition 0.000 claims description 2
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 claims description 2
- 235000019486 Sunflower oil Nutrition 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000002600 sunflower oil Substances 0.000 claims 1
- 239000000686 essence Substances 0.000 abstract description 10
- 230000036541 health Effects 0.000 abstract description 4
- 239000002552 dosage form Substances 0.000 abstract description 2
- 238000009776 industrial production Methods 0.000 abstract description 2
- 235000015097 nutrients Nutrition 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 21
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 12
- 239000011575 calcium Substances 0.000 description 12
- 229910052791 calcium Inorganic materials 0.000 description 12
- 210000000988 bone and bone Anatomy 0.000 description 11
- 235000010384 tocopherol Nutrition 0.000 description 11
- 229960001295 tocopherol Drugs 0.000 description 11
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 238000012360 testing method Methods 0.000 description 8
- 229940088594 vitamin Drugs 0.000 description 6
- 229930003231 vitamin Natural products 0.000 description 6
- 235000013343 vitamin Nutrition 0.000 description 6
- 239000011782 vitamin Substances 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 230000037182 bone density Effects 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 4
- 235000012716 cod liver oil Nutrition 0.000 description 4
- 239000003026 cod liver oil Substances 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 239000011574 phosphorus Substances 0.000 description 4
- 229910052698 phosphorus Inorganic materials 0.000 description 4
- 239000007901 soft capsule Substances 0.000 description 4
- 239000011653 vitamin D2 Substances 0.000 description 4
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 3
- 230000009102 absorption Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 229960002061 ergocalciferol Drugs 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 230000001502 supplementing effect Effects 0.000 description 3
- 235000001892 vitamin D2 Nutrition 0.000 description 3
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 3
- XOBOCRSRGDBOGH-UHFFFAOYSA-N 5-phenylnonan-5-ol Chemical compound CCCCC(O)(CCCC)C1=CC=CC=C1 XOBOCRSRGDBOGH-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- MRELNEQAGSRDBK-UHFFFAOYSA-N lanthanum(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[La+3].[La+3] MRELNEQAGSRDBK-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- 235000005282 vitamin D3 Nutrition 0.000 description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 2
- 229940021056 vitamin d3 Drugs 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- OCKGFTQIICXDQW-ZEQRLZLVSA-N 5-[(1r)-1-hydroxy-2-[4-[(2r)-2-hydroxy-2-(4-methyl-1-oxo-3h-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3h-2-benzofuran-1-one Chemical compound C1=C2C(=O)OCC2=C(C)C([C@@H](O)CN2CCN(CC2)C[C@H](O)C2=CC=C3C(=O)OCC3=C2C)=C1 OCKGFTQIICXDQW-ZEQRLZLVSA-N 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000008452 baby food Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000009924 canning Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000014106 fortified food Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 208000005368 osteomalacia Diseases 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
- A23L29/04—Fatty acids or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention belongs to the technical field of health product production, and particularly relates to a drop containing vitamin A and vitamin D and a preparation method thereof. The drop containing vitamin A and vitamin D of the invention mainly comprises vitamin A oil, vitamin D oil, edible vegetable oil, edible essence, emulsifier and antioxidant. Wherein the vitamin A oil comprises retinyl acetate, corn oil, and dibutyl hydroxy toluene, and the vitamin D oil comprises vitamin D3Corn oil, dibutyl hydroxy toluene and vitamin E. According to the drop containing vitamin A and vitamin D, provided by the invention, the vitamin A and the vitamin D are simultaneously supplemented, the drop dosage form is selected, and the HUT sterilization mode is adopted, so that the nutrients can be effectively prevented from being damaged, the drop is more convenient for the baby to eat, and the safety and the stability are high. In addition, the drop containing vitamin A and vitamin D provided by the invention is simple in preparation process, energy-saving and environment-friendly, and easy to realize industrial production.
Description
Technical Field
The invention belongs to the technical field of health product production, and particularly relates to a drop containing vitamin A and vitamin D and a preparation method thereof.
Background
Vitamins, also known as vitamins, are, colloquially, life-sustaining substances and are a class of organic compounds essential to the maintenance of physical health. At present, more than ten vitamins are found, such as vitamin a, vitamin B, vitamin C, vitamin D, and the like, and are generally classified into fat-soluble vitamins and water-soluble vitamins. Fat-soluble vitamins, including vitamin A, D, E, K and its derivatives, are essential substances for maintaining the normal growth, development, metabolism and physiological functions of the body.
Vitamin A, also called as retinol, exists only in animal food, has gene regulating effect, and also has the effect equivalent to steroid hormone, and can promote synthesis of glycoprotein, promote growth and development, strengthen bones, and maintain health of hair, teeth and gum. In addition, vitamin A is helpful for maintaining the immune system to function normally, enhancing the body resistance to infections, particularly respiratory tract infections and parasitic infections, and treating emphysema and hyperthyroidism. Vitamin D is sterol derivative, also called calciferol or calciferol, mainly containing vitamin D2Namely ergocalciferol and vitamin D3I.e., cholecalciferol. Vitamin D3Has the activity of remarkably regulating the metabolism of calcium and phosphorus, and can promote the absorption and conversion of the small intestine mucosa to phosphorus and promote the reabsorption of the renal tubules to calcium and phosphorus. In the skeleton, vitamin D3 not only helps to calcify new bone, but also promotes the release of calcium from old bone marrow, thus continuously renewing bone mass, and simultaneously maintaining the balance of blood and calcium. Vitamin D has the function of regulating calcium, so that it is necessary for normal development of bones and teeth, and especially for pregnant women, infants and young people, the demand is greater. If vitamin D is not sufficient, the blood calcium and phosphorus are lower than normal, and the bones become soft and malformed: rickets occur in children, and osteomalacia in pregnant women.
For infants, vitamin A and vitamin D are indispensable nutritional components in the growth and development process of babies, are particularly important for the growth of bones, and the current co-tonic products of vitamin A and vitamin D mainly comprise cod liver oil and soft capsules. However, as cod liver oil is judged as a health food, when reporting is required, the soft capsule can be put on record and shorten reporting time, but the soft capsule is inconvenient to eat and is not beneficial to eating by infants.
The present invention is to provide a drop containing vitamin a and vitamin D to solve the above problems.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a drop containing vitamin A and vitamin D and a preparation method thereof. The product of the invention aims at simultaneously supplementing vitamin A and vitamin D, adopts a drop formulation which is convenient for babies to eat, and has high safety and good stability.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a drop containing vitamin A and vitamin D comprises the following components in parts by weight:
1-10 parts of vitamin A oil, 0.6-6 parts of vitamin D oil, 190 parts of edible vegetable oil 170-containing material, 2-4 parts of edible essence, 0.2-4 parts of emulsifier and 0.2-4 parts of antioxidant.
Further, the drop containing vitamin A and vitamin D comprises the following components in parts by weight: 6.7 parts of vitamin A oil, 4.9 parts of vitamin D oil, 182 parts of edible vegetable oil, 2.4 parts of edible essence, 2.6 parts of emulsifier and 1.4 parts of antioxidant.
Further, the vitamin A oil in the drops containing the vitamin A and the vitamin D comprises the following components in parts by weight: 2-10 parts of retinyl acetate, 25-50 parts of corn oil and 1-5 parts of butylated hydroxytoluene.
Further, the vitamin A oil in the drops containing the vitamin A and the vitamin D comprises the following components in parts by weight: 6.5 parts of retinyl acetate, 38 parts of corn oil and 2.6 parts of butylated hydroxytoluene.
Further, the vitamin D oil in the drops containing vitamin A and vitamin D comprises the following components in parts by weight: vitamin D310-20 parts of corn oil, 30-60 parts of dibutyl hydroxy toluene and 5-10 parts of vitamin E.
Furthermore, the vitamin D oil in the drops containing the vitamin A and the vitamin D comprises the following components in parts by weight: vitamin D317 parts of corn oil, 56 parts of dibutyl hydroxy toluene and 8.3 parts of vitamin E.
Furthermore, the vitamin E in the vitamin D oil is vitamin E of mixed tocopherols.
Furthermore, the vegetable oil in the drop containing vitamin A and vitamin D is one or more of olive oil, rapeseed oil, sunflower seed oil, soybean oil and corn oil.
Further, the emulsifier in the drops containing vitamin a and vitamin D is a phospholipid.
Furthermore, the antioxidant in the drop containing vitamin A and vitamin D is one or more of vitamin E, beta-carotene and vitamin C.
The invention also provides a preparation method of the drop containing vitamin A and vitamin D, which comprises the following specific steps:
s1, adding the vitamin A oil and the vitamin D oil into the edible vegetable oil, uniformly stirring, and homogenizing for 10 minutes at the homogenizing rotation speed of 200rpm to obtain a mixed solution A;
s2, heating the mixed solution A prepared in the step S1 to 50 ℃, adding edible essence, emulsifier and antioxidant, uniformly stirring, and homogenizing for 20 minutes at the rotation speed of 300rpm to prepare a mixed solution B;
s3, cooling the mixed solution B prepared in the step S2 to room temperature, and filtering by using a 5-micron filter element at the flow rate of 2cc/S to prepare filtrate C;
s4, sterilizing the filtrate C prepared in the step S3 by UHT ultrahigh temperature instant sterilization, wherein the sterilization temperature is 110-;
s5, filling and sealing the sterilized liquid, and packaging to obtain the product.
Further, in the preparation method of the drops containing vitamin A and vitamin D, the preparation method of the vitamin A oil comprises the following steps: heating corn oil to 40-60 deg.C, adding retinyl acetate and dibutyl hydroxy toluene, stirring for 30-60 min, filtering with 200 mesh intact filter cloth, cooling to room temperature, and packaging.
Further, in the preparation method of the drops containing vitamin A and vitamin D, the preparation method of the vitamin D oil comprises the following steps: heating corn oil to 40-60 deg.C, adding vitamin D3Dibutyl hydroxy toluene and vitamin E, stirring for 30-60 min, filtering with 200 mesh intact filter cloth, and coolingCooling to room temperature, and packaging.
The vitamin A and the vitamin D are introduced into the drop containing the vitamin A and the vitamin D in a mode of adopting vitamin A oil and vitamin D oil. The dibutyl hydroxy toluene is added in the process of preparing the vitamin A oil, so that the vitamin A is prevented from being oxidized before being eaten, the activity of the vitamin A is ensured, and the utilization rate of the vitamin A is improved. Retinyl acetate is also called vitamin A acetate or vitamin A acetate, is a nutrition enhancer capable of supplementing vitamin A, has no rancidity taste when being eaten, and is more suitable for infants. The vitamin D oil is added with the dibutyl hydroxy toluene and the vitamin E of the mixed tocopherol in the preparation process, so that the activity of the vitamin D is ensured, and the utilization rate of the vitamin D is improved. The tocopherol is a hydrolysate of vitamin E, has strong activity, is a natural oil-soluble antioxidant, and is used as an antioxidant and a nutrition enhancer of infant food, curative effect food and fortified food. In addition, the vitamin A oil and the vitamin D oil provided by the invention use vegetable oil such as corn oil, olive oil, rapeseed oil, soybean oil and the like as oil-soluble base materials, are natural and environment-friendly, and are easy to absorb.
Compared with the prior art, the invention has the beneficial effects that:
1. the drop containing the vitamin A and the vitamin D provided by the invention aims at simultaneously supplementing the vitamin A and the vitamin D, and the drop dosage form is selected, so that the drop can be more convenient for a baby to eat, and is high in safety and good in stability.
2. The drop containing the vitamin A and the vitamin D provided by the invention adopts an HUT sterilization mode, is sterilized before canning, has high temperature and short time, and can effectively avoid the damage of nutrients, thereby improving the stability of the product quality.
3. The drop containing the vitamin A and the vitamin D provided by the invention is simple in preparation process, energy-saving and environment-friendly, and easy to realize industrial production.
Detailed Description
The present invention will be further described below by way of specific embodiments, but the present invention is not limited to only the following examples. Various modifications can be made by those skilled in the art based on the basic idea of the invention, but they are within the scope of the invention as long as they do not depart from the basic idea of the invention.
Examples 1 to 6 and comparative examples 1 to 3
Table 1 lists the components and parts by weight of vitamin A and vitamin D drops of examples 1-6 and comparative examples 1-3 of the present invention; table 2 shows the components and parts by weight of vitamin A oil in vitamin A and vitamin D drops of examples 1-6 and comparative examples 1-3; table 3 lists the components and parts by weight of vitamin D oil in vitamin A and vitamin D drops for examples 1-6 and comparative examples 1-3.
TABLE 1 examples and comparative examples vitamin A and vitamin D drop compositions and parts by weight
TABLE 2 vitamin A oil component and parts by weight in the examples and comparative examples drops
TABLE 3 vitamin D oil component and parts by weight in the examples and comparative examples
Example 1A drop containing vitamin A and vitamin D
The vitamin E in the vitamin D oil is vitamin E of mixed tocopherol.
The vegetable oil in the drop containing vitamin A and vitamin D consists of olive oil and rapeseed oil according to the weight ratio of 1: 1.
The emulsifier in the drops containing vitamin a and vitamin D is a phospholipid.
The antioxidant in the drop containing vitamin A and vitamin D consists of vitamin E and vitamin C in a weight ratio of 2: 1.
The invention also provides a preparation method of the drop containing vitamin A and vitamin D, which comprises the following specific steps:
s1, adding the vitamin A oil and the vitamin D oil into the edible vegetable oil, uniformly stirring, and homogenizing for 10 minutes at the homogenizing rotation speed of 200rpm to obtain a mixed solution A;
s2, heating the mixed solution A to 50 ℃, adding edible essence, an emulsifier and an antioxidant, uniformly stirring, and homogenizing for 20 minutes at the homogenizing rotation speed of 300rpm to obtain a mixed solution B;
s3, cooling the mixed solution B to room temperature, and filtering by using a 5-micron filter element at the flow rate of 2cc/S to obtain a filtrate C;
s4, sterilizing the filtrate C by UHT ultrahigh temperature instant sterilization, wherein the sterilization temperature is 110 ℃, and the sterilization time is 8S;
s5, filling and sealing the sterilized liquid, and packaging to obtain the product.
The preparation method of the vitamin A oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 40 deg.C, adding retinyl acetate and dibutyl hydroxy toluene, stirring for 30 min, filtering with 200 mesh intact filter cloth, cooling to room temperature, and packaging.
The preparation method of the vitamin D oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 40 deg.C, adding vitamin D3And the dibutyl hydroxy toluene and the vitamin E are stirred for 30 minutes, then are filtered by intact filter cloth with 200 meshes, are cooled to room temperature and are packaged to obtain the vitamin E.
Example 2A drop containing vitamin A and vitamin D
The vitamin E in the vitamin D oil is vitamin E of mixed tocopherol.
The vegetable oil in the drop containing vitamin A and vitamin D consists of rapeseed oil and soybean oil according to the weight ratio of 2: 1.
The emulsifier in the drops containing vitamin a and vitamin D is a phospholipid.
The antioxidant in the drop containing vitamin A and vitamin D consists of beta-carotene and vitamin C according to the weight ratio of 1: 1.
The invention also provides a preparation method of the drop containing vitamin A and vitamin D, which comprises the following specific steps:
s1, adding the vitamin A oil and the vitamin D oil into the edible vegetable oil, uniformly stirring, and homogenizing for 10 minutes at the homogenizing rotation speed of 200rpm to obtain a mixed solution A;
s2, heating the mixed solution A to 50 ℃, adding edible essence, an emulsifier and an antioxidant, uniformly stirring, and homogenizing for 20 minutes at the homogenizing rotation speed of 300rpm to obtain a mixed solution B;
s3, cooling the mixed solution B to room temperature, and filtering by using a 5-micron filter element at the flow rate of 2cc/S to obtain a filtrate C;
s4, sterilizing the filtrate C by UHT ultrahigh temperature instant sterilization, wherein the sterilization temperature is 115 ℃ and the sterilization time is 7S;
s5, filling and sealing the sterilized liquid, and packaging to obtain the product.
The preparation method of the vitamin A oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 45 deg.C, adding retinyl acetate and dibutyl hydroxy toluene, stirring for 35 min, filtering with 200 mesh intact filter cloth, cooling to room temperature, and packaging.
The preparation method of the vitamin D oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 45 deg.C, adding vitamin D3And the dibutyl hydroxy toluene and the vitamin E are stirred for 35 minutes, then are filtered by intact filter cloth with 200 meshes, are cooled to room temperature and are packaged to obtain the vitamin E.
Example 3A drop containing vitamin A and vitamin D
The vitamin E in the vitamin D oil is vitamin E of mixed tocopherol.
The vegetable oil in the drops containing vitamin A and vitamin D is soybean oil.
The emulsifier in the drops containing vitamin a and vitamin D is a phospholipid.
The antioxidant in the drop containing vitamin A and vitamin D consists of vitamin C and vitamin E according to the weight ratio of 1: 1.
The invention also provides a preparation method of the drop containing vitamin A and vitamin D, which comprises the following specific steps:
s1, adding the vitamin A oil and the vitamin D oil into the edible vegetable oil, uniformly stirring, and homogenizing for 10 minutes at the homogenizing rotation speed of 200rpm to obtain a mixed solution A;
s2, heating the mixed solution A to 50 ℃, adding edible essence, an emulsifier and an antioxidant, uniformly stirring, and homogenizing for 20 minutes at the homogenizing rotation speed of 300rpm to obtain a mixed solution B;
s3, cooling the mixed solution B to room temperature, and filtering by using a 5-micron filter element at the flow rate of 2cc/S to obtain a filtrate C;
s4, sterilizing the filtrate C by UHT ultrahigh temperature instant sterilization, wherein the sterilization temperature is 120 ℃, and the sterilization time is 6S;
s5, filling and sealing the sterilized liquid, and packaging to obtain the product.
The preparation method of the vitamin A oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 50 deg.C, adding retinyl acetate and dibutyl hydroxy toluene, stirring for 40 min, filtering with 200 mesh intact filter cloth, cooling to room temperature, and packaging.
The preparation method of the vitamin D oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 50 deg.C, adding vitamin D3And the dibutyl hydroxy toluene and the vitamin E are stirred for 40 minutes, then are filtered by intact filter cloth with 200 meshes, are cooled to room temperature and are packaged to obtain the vitamin E.
Example 4A drop containing vitamin A and vitamin D
The vitamin E in the vitamin D oil is vitamin E of mixed tocopherol.
The vegetable oil in the drop containing vitamin A and vitamin D consists of corn oil and olive oil according to the weight ratio of 1: 1.
The emulsifier in the drops containing vitamin a and vitamin D is a phospholipid.
The antioxidant in the drop containing vitamin A and vitamin D consists of vitamin E and beta-carotene according to the weight ratio of 2: 1.
The invention also provides a preparation method of the drop containing vitamin A and vitamin D, which comprises the following specific steps:
s1, adding the vitamin A oil and the vitamin D oil into the edible vegetable oil, uniformly stirring, and homogenizing for 10 minutes at the homogenizing rotation speed of 200rpm to obtain a mixed solution A;
s2, heating the mixed solution A to 50 ℃, adding edible essence, an emulsifier and an antioxidant, uniformly stirring, and homogenizing for 20 minutes at the homogenizing rotation speed of 300rpm to obtain a mixed solution B;
s3, cooling the mixed solution B to room temperature, and filtering by using a 5-micron filter element at the flow rate of 2cc/S to obtain a filtrate C;
s4, sterilizing the filtrate C by UHT ultrahigh temperature instant sterilization, wherein the sterilization temperature is 127 ℃, and the sterilization time is 5S;
s5, filling and sealing the sterilized liquid, and packaging to obtain the product.
The preparation method of the vitamin A oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 53 deg.C, adding retinyl acetate and dibutyl hydroxy toluene, stirring for 47 min, filtering with 200 mesh intact filter cloth, cooling to room temperature, and packaging.
The preparation method of the vitamin D oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 47 deg.C, adding vitamin D3And the dibutyl hydroxy toluene and the vitamin E are stirred for 45 minutes, then are filtered by intact filter cloth with 200 meshes, are cooled to room temperature and are packaged to obtain the vitamin E.
Example 5A drop containing vitamin A and vitamin D
The vitamin E in the vitamin D oil is vitamin E of mixed tocopherol.
The vegetable oil in the drop containing vitamin A and vitamin D consists of corn oil and olive oil according to the weight ratio of 2: 1.
The emulsifier in the drops containing vitamin a and vitamin D is a phospholipid.
The antioxidant in the drop containing vitamin A and vitamin D consists of vitamin C and beta-carotene according to the weight ratio of 1: 2.
The invention also provides a preparation method of the drop containing vitamin A and vitamin D, which comprises the following specific steps:
s1, adding the vitamin A oil and the vitamin D oil into the edible vegetable oil, uniformly stirring, and homogenizing for 10 minutes at the homogenizing rotation speed of 200rpm to obtain a mixed solution A;
s2, heating the mixed solution A to 50 ℃, adding edible essence, an emulsifier and an antioxidant, uniformly stirring, and homogenizing for 20 minutes at the homogenizing rotation speed of 300rpm to obtain a mixed solution B;
s3, cooling the mixed solution B to room temperature, and filtering by using a 5-micron filter element at the flow rate of 2cc/S to obtain a filtrate C;
s4, sterilizing the filtrate C by UHT ultrahigh temperature instant sterilization, wherein the sterilization temperature is 125 ℃, and the sterilization time is 4S;
s5, filling and sealing the sterilized liquid, and packaging to obtain the product.
The preparation method of the vitamin A oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 55 deg.C, adding retinyl acetate and dibutyl hydroxy toluene, stirring for 50 min, filtering with 200 mesh intact filter cloth, cooling to room temperature, and packaging.
The preparation method of the vitamin D oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 55 deg.C, adding vitamin D3And the dibutyl hydroxy toluene and the vitamin E are stirred for 50 minutes, then are filtered by intact filter cloth with 200 meshes, are cooled to room temperature and are packaged to obtain the vitamin E.
Example 6A drop containing vitamin A and vitamin D
The vitamin E in the vitamin D oil is vitamin E of mixed tocopherol.
The vegetable oil in the drop containing vitamin A and vitamin D consists of corn oil and soybean oil according to the weight ratio of 1: 1.
The emulsifier in the drops containing vitamin a and vitamin D is a phospholipid.
The antioxidant in the drop containing vitamin A and vitamin D consists of beta-carotene and vitamin E according to the weight ratio of 1: 1.
The invention also provides a preparation method of the drop containing vitamin A and vitamin D, which comprises the following specific steps:
s1, adding the vitamin A oil and the vitamin D oil into the edible vegetable oil, uniformly stirring, and homogenizing for 10 minutes at the homogenizing rotation speed of 200rpm to obtain a mixed solution A;
s2, heating the mixed solution A to 50 ℃, adding edible essence, an emulsifier and an antioxidant, uniformly stirring, and homogenizing for 20 minutes at the homogenizing rotation speed of 300rpm to obtain a mixed solution B;
s3, cooling the mixed solution B to room temperature, and filtering by using a 5-micron filter element at the flow rate of 2cc/S to obtain a filtrate C;
s4, sterilizing the filtrate C by UHT ultrahigh temperature instant sterilization, wherein the sterilization temperature is 130 ℃, and the sterilization time is 3S;
s5, filling and sealing the sterilized liquid, and packaging to obtain the product.
The preparation method of the vitamin A oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 60 deg.C, adding retinyl acetate and dibutyl hydroxy toluene, stirring for 60 min, filtering with 200 mesh intact filter cloth, cooling to room temperature, and packaging.
The preparation method of the vitamin D oil in the preparation method of the drops containing the vitamin A and the vitamin D comprises the following steps: heating corn oil to 60 deg.C, adding vitamin D3Dibutyl hydroxy toluene and vitamin E, stirring for 60 minutesFiltering with 200 mesh intact filter cloth, cooling to room temperature, and packaging.
Comparative example 1, a drop containing vitamin A and vitamin D
The vitamin E in the vitamin D oil is vitamin E of mixed tocopherol.
The vegetable oil in the drop containing vitamin A and vitamin D consists of corn oil and olive oil according to the weight ratio of 1: 1.
The emulsifier in the drops containing vitamin a and vitamin D is a phospholipid.
The antioxidant in the drop containing vitamin A and vitamin D consists of vitamin E and beta-carotene according to the weight ratio of 2: 1.
The preparation method of the drops containing vitamin A and vitamin D, the vitamin A oil and the vitamin D oil is similar to that of example 4.
This comparative example differs from example 4 in that the amounts of vitamin a oil and vitamin D oil were varied.
Comparative example 2, a drop containing vitamin A and vitamin D
The vegetable oil in the drop containing vitamin A and vitamin D consists of corn oil and olive oil according to the weight ratio of 1: 1.
The emulsifier in the drops containing vitamin a and vitamin D is a phospholipid.
The antioxidant in the drop containing vitamin A and vitamin D consists of vitamin E and beta-carotene according to the weight ratio of 2: 1.
The preparation method of the drops containing vitamin A and vitamin D, the vitamin A oil and the vitamin D oil is similar to that of example 4.
The difference between this comparative example and example 4 is that vitamin E used in vitamin D does not contain tocopherol.
Comparative example 3 drop containing vitamin A and vitamin D
The vitamin E in the vitamin D oil is vitamin E of mixed tocopherol.
The vegetable oil in the drop containing vitamin A and vitamin D consists of corn oil and olive oil according to the weight ratio of 1: 1.
The emulsifier in the drops containing vitamin a and vitamin D is a phospholipid.
The antioxidant in the drop containing vitamin A and vitamin D consists of vitamin E and beta-carotene according to the weight ratio of 1: 1.
The preparation method of the drops containing vitamin A and vitamin D, the vitamin A oil and the vitamin D oil is similar to that of example 4.
The comparative example differs from example 4 in that the retinyl acetate in the vitamin A oil is replaced by vitamin A.
Comparative examples 4,
The comparative example is a cod liver oil soft capsule produced by Hangzhou Haiwang bioengineering Co.Ltd in the market, and the approved document is national food Jian character G20140354.
Test example I, stability evaluation
Test samples: drops containing vitamin A and vitamin D obtained in examples 1 to 6 and comparative examples 1 to 4.
The test method comprises the following steps: the test samples were stored in an oven at 50 ℃ under sunlight and in a freezer of a refrigerator for 18 months, respectively, and every 3 months, the color of the samples was checked for a change. Among them, cod liver oil capsules purchased in comparative example 4 were tested by puncturing the outer skin of the capsules and weighing the same as the other samples. The test results are shown in table 4.
Table 4 stability evaluation of drops containing vitamin a and vitamin D
As can be seen from Table 4, the drops containing vitamin A and vitamin D provided by the invention can well reduce the discoloration problem of the sterilized product, have high safety and good stability, and can be stored for a long time at high temperature (below 50 ℃) and under the irradiation of sunlight.
Test example two, Performance test
Test samples: drops containing vitamin A and vitamin D obtained in examples 1 to 6 and comparative examples 1 to 4.
The test method comprises the following steps: 110 female rats of 3 months of age having rat osteoporosis were selected and randomly divided into 11 groups, which were set as examples 1 to 6, comparative examples 1 to 4, and a blank example, respectively. The other groups were administered daily at 0.2mg/10g body weight except for the empty control group, and were kept for 8 weeks. Bone calcium and bone density of rat femurs were measured after the experiment was completed. The test results are shown in Table 5.
Measuring femoral density: the femoral samples were examined for bone density at the midpoint and distal end using a single photon bone densitometer (SD-1000). Calcium absorption experiments and bone calcium content determination: weighing the right femur dried to constant weight, wet digesting with mixed acid (nitric acid: perchloric acid 4:1), fixing the volume with 0.5% lanthanum oxide solution, and measuring the calcium content with atomic absorption spectrophotometer.
TABLE 5 Effect of drops containing vitamin A and vitamin D on bone calcium and bone Density
As can be seen from Table 5, the bone density and bone calcium of the groups of examples 1 to 6 were significantly increased compared with the blank group, which indicates that the drop containing vitamin A and vitamin D provided by the invention can significantly increase the bone density of rats and promote the growth of rats. The embodiment 4 has the most obvious effect and is the best embodiment of the invention. The test effect of the comparative example 2 and the comparative example 3 is poor, which shows that the components in the formula provided by the invention play a synergistic effect and achieve the optimal effect.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Those skilled in the art will recognize that changes may be made to the embodiments described above without departing from the spirit and scope of the invention. Therefore, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the technical spirit of the present invention are covered by the claims of the present invention.
Claims (10)
1. A drop containing vitamin A and vitamin D is characterized by comprising the following components in parts by weight: 1-10 parts of vitamin A oil, 0.6-6 parts of vitamin D oil, 190 parts of edible vegetable oil 170-containing material, 2-4 parts of edible essence, 0.2-4 parts of emulsifier and 0.2-4 parts of antioxidant.
2. Drops according to claim 1 containing vitamin A and vitamin D, characterized in that said vitamin A oil comprises the following components and their parts by weight: 2-10 parts of retinyl acetate, 25-50 parts of corn oil and 1-5 parts of butylated hydroxytoluene.
3. Drops according to claim 1 containing vitamin A and vitamin D, characterized in that the vitamin D oil comprises the following ingredients and their parts by weight: vitamin D310-20 parts of corn oil, 30-60 parts of dibutyl hydroxy toluene and 5-10 parts of vitamin E.
4. Drops according to claim 6 containing vitamin A and vitamin D, characterized in that the vitamin E in the vitamin D oil is vitamin E mixed with tocopherols.
5. Drops according to claim 1 containing vitamin a and vitamin D, characterized in that said vegetable oil is one or more of olive oil, rapeseed oil, sunflower oil, soybean oil, corn oil.
6. A drop according to claim 1, containing vitamin a and vitamin D, characterized in that said emulsifier is a phospholipid.
7. Drops according to claim 1 containing vitamin a and vitamin D, characterized in that the antioxidant is one of vitamin E, β -carotene, vitamin C.
8. A method of preparation of drops containing vitamin A and vitamin D according to any of the claims from 1 to 7, characterized in that it comprises the following steps:
s1, adding the vitamin A oil and the vitamin D oil into the edible vegetable oil, uniformly stirring, and homogenizing for 10 minutes at the homogenizing rotation speed of 200rpm to obtain a mixed solution A;
s2, heating the mixed solution A prepared in the step S1 to 50 ℃, adding edible essence, an emulsifier and an antioxidant, uniformly stirring, and homogenizing for 20 minutes at the rotation speed of 300rpm to prepare a mixed solution B;
s3, cooling the mixed solution B prepared in the step S2 to room temperature, and filtering by using a 5-micron filter element at the flow rate of 2cc/S to prepare filtrate C;
s4, sterilizing the filtrate C prepared in the step S3 by UHT ultrahigh temperature instant sterilization, wherein the sterilization temperature is 110-;
s5, filling and sealing the sterilized liquid, and packaging to obtain the product.
9. A method of making drops containing vitamin A and vitamin D as claimed in claim 8, wherein said vitamin A oil is prepared by: heating corn oil to 40-60 deg.C, adding retinyl acetate and dibutyl hydroxy toluene, stirring for 30-60 min, filtering with 200 mesh intact filter cloth, cooling to room temperature, and packaging.
10. A method of making drops containing vitamin A and vitamin D as claimed in claim 8 wherein the vitamin D oil is prepared by: heating corn oil to 40-60 deg.C, adding vitamin D3And the dibutyl hydroxy toluene and the vitamin E are stirred for 30-60 minutes, then are filtered by intact filter cloth with 200 meshes, and are packaged after being cooled to room temperature.
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