CN110339162A - A kind of vitamins drops and preparation method thereof - Google Patents
A kind of vitamins drops and preparation method thereof Download PDFInfo
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- CN110339162A CN110339162A CN201910672404.8A CN201910672404A CN110339162A CN 110339162 A CN110339162 A CN 110339162A CN 201910672404 A CN201910672404 A CN 201910672404A CN 110339162 A CN110339162 A CN 110339162A
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- Prior art keywords
- vitamin
- drops
- corn oil
- vitamins
- oil
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- 229940088594 vitamin Drugs 0.000 title claims abstract description 60
- 229930003231 vitamin Natural products 0.000 title claims abstract description 60
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 60
- 239000011782 vitamin Substances 0.000 title claims abstract description 60
- 238000002360 preparation method Methods 0.000 title claims description 18
- 239000002285 corn oil Substances 0.000 claims abstract description 83
- 235000005687 corn oil Nutrition 0.000 claims abstract description 83
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims abstract description 29
- 235000019498 Walnut oil Nutrition 0.000 claims abstract description 29
- 239000008170 walnut oil Substances 0.000 claims abstract description 29
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims abstract description 28
- 239000011647 vitamin D3 Substances 0.000 claims abstract description 28
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims abstract description 26
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 22
- 238000003756 stirring Methods 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 3
- 238000004806 packaging method and process Methods 0.000 claims description 18
- 239000000706 filtrate Substances 0.000 claims description 16
- 239000005361 soda-lime glass Substances 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 13
- 238000011049 filling Methods 0.000 claims description 10
- 238000007873 sieving Methods 0.000 claims description 10
- 238000004090 dissolution Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 8
- 239000006166 lysate Substances 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 235000019198 oils Nutrition 0.000 claims description 2
- WWDMJSSVVPXVSV-YCNIQYBTSA-N retinyl ester Chemical compound CC1CCCC(C)(C)C1\C=C\C(\C)=C\C=C\C(\C)=C\C(O)=O WWDMJSSVVPXVSV-YCNIQYBTSA-N 0.000 claims 3
- 235000021419 vinegar Nutrition 0.000 claims 3
- 239000000052 vinegar Substances 0.000 claims 3
- 244000144730 Amygdalus persica Species 0.000 claims 1
- 235000006040 Prunus persica var persica Nutrition 0.000 claims 1
- 229960000342 retinol acetate Drugs 0.000 abstract description 15
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 abstract description 15
- 235000019173 retinyl acetate Nutrition 0.000 abstract description 15
- 239000011770 retinyl acetate Substances 0.000 abstract description 15
- 239000007788 liquid Substances 0.000 abstract description 12
- 235000013305 food Nutrition 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 7
- 239000002552 dosage form Substances 0.000 abstract description 4
- 238000011161 development Methods 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 230000003647 oxidation Effects 0.000 abstract description 2
- 238000007254 oxidation reaction Methods 0.000 abstract description 2
- -1 polypropylene Polymers 0.000 abstract description 2
- 239000004743 Polypropylene Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229920001155 polypropylene Polymers 0.000 abstract 1
- 238000011068 loading method Methods 0.000 description 28
- 238000007789 sealing Methods 0.000 description 13
- 238000000465 moulding Methods 0.000 description 12
- 239000000047 product Substances 0.000 description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 7
- 238000007689 inspection Methods 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 229930003316 Vitamin D Natural products 0.000 description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 4
- 235000019155 vitamin A Nutrition 0.000 description 4
- 239000011719 vitamin A Substances 0.000 description 4
- 239000011710 vitamin D Substances 0.000 description 4
- 235000019166 vitamin D Nutrition 0.000 description 4
- 150000003710 vitamin D derivatives Chemical class 0.000 description 4
- 229940046008 vitamin d Drugs 0.000 description 4
- 235000000072 L-ascorbyl-6-palmitate Nutrition 0.000 description 3
- 235000019774 Rice Bran oil Nutrition 0.000 description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000010977 jade Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000008165 rice bran oil Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 229940045997 vitamin a Drugs 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011570 nicotinamide Substances 0.000 description 2
- 235000005152 nicotinamide Nutrition 0.000 description 2
- 229960003966 nicotinamide Drugs 0.000 description 2
- 229960003471 retinol Drugs 0.000 description 2
- 235000020944 retinol Nutrition 0.000 description 2
- 239000011607 retinol Substances 0.000 description 2
- 208000007442 rickets Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 229940097411 palm acid Drugs 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 150000002266 vitamin A derivatives Chemical class 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Physiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of vitamins drops, contain: vitamin, ascorbyl palmitate, corn oil and walnut oil, wherein vitamin is vitamin D3Or retinol acetate and vitamin D3Mixture, by the way that vitamin and ascorbyl palmitate are dissolved in the miscella of corn oil and walnut oil, stirring, the method of polypropylene filter filtering obtains, the present invention cooperates vitamin and ascorbyl palmitate jointly, its dosage and dosage form have fully considered the suitability of infant taking, accuracy and convenience, the vitamin of infant's shortage can safely and effectively be supplemented, have compared with other dosage forms convenient to take, dosage is accurate, the advantages that easy to carry and transport, vitamin necessary to infant's body can be supplemented simultaneously, the oxidation resistance and immunocompetence of human body can be enhanced, enhancing development, it is drawn at liquid to regulation graduation mark when edible with matched dropper, in direct housing instills mouth, or it is added in other foods and eats.
Description
Technical field
The present invention relates to a kind of drops and preparation method thereof, and in particular to a kind of vitamins drops and preparation method thereof,
Belong to nutrition and health care field.
Background technique
Vitamin is a kind of with the various metabolic functions of human body are adjusted, and maintains body vital movement and health essential
Nutrient.It cannot or can hardly be synthesized in human body, it is necessary to be absorbed from food.Vitamin can be divided into rouge by its dissolubility
Two kinds of dissolubility and water solubility.Liposoluble vitamin class hardening agent mainly has vitamin A, vitamin D, vitamin E etc., they can be used
In the food such as grease, noodles.Water-soluble vitamins hardening agent mainly has vitamin C, vitamin B1, vitamin B2, niacin or
Niacinamide etc., they can be used in the food such as bread, biscuit.
Retinol acetate is a kind of retinol (vitamin A) derivative, is a kind of substance with retinol bioactivity,
With adjust epidermis and cuticula metabolism, reduce seborrhea, prevention yctalopia and the blurring of image, promote bone growth,
Pre- preventing obesity, prevention and treatment alopecia and other effects.
Vitamin D is currently widely used for the rickets of prevention and treatment children and the rickets of adult, arthralgia etc..With bone
The people of matter osteoporosis can effectively improve the trap of calcium ion by adding suitable vitamin D and magnesium.In addition to this, it ties up
Raw element D also be used to reduce the probability of colon cancer, breast cancer and prostate cancer, also have humidification to immune system.
Summary of the invention
It is directed to defect in the prior art, the present invention provides a kind of vitamins drops and preparation method thereof, include
Vitamin A and/or vitamin D3, dosage is accurate, convenient to take.
Specifically, the present invention adopts the following technical scheme:
A kind of vitamins drops, contains: vitamin, ascorbyl palmitate, corn oil and walnut oil；
Wherein, vitamin is vitamin D3Or retinol acetate and vitamin D3Mixture.
Drops of the invention is designed for infant, dosage and dosage form fully considered infant taking suitability,
Accuracy and convenience, can safely and effectively supplement infant shortage vitamin, with other dosage forms compared with it is convenient to take,
The advantages that dosage is accurate, easy to carry and transport, also, vitamin and ascorbyl palmitate are total to by the invention
With cooperation, using corn oil and walnut oil as solvent, not only palatability is good, and each side's surface properties of drops are superior, and can also be same
When supplement infant's body necessary to vitamin, can enhance the oxidation resistance and immunocompetence of human body, enhancing development, food
Used time is drawn at liquid to regulation graduation mark with matched dropper, in direct housing instills mouth, or is added in other foods and is eaten.
Further, contain in every 30ml drops: vitamin D30.40-0.45mg, ascorbyl palmitate 10-15mg,
Corn oil 25-29mL, walnut oil 1-5ml, it is preferred that vitamin D30.432mg, ascorbyl palmitate 12mg, corn oil
29mL, walnut oil 1ml；
Or,
Contain in every 30ml drops: retinol acetate 28-32mg, vitamin D30.25-0.30mg, vitamin-c palmitate
Ester 10-15mg, corn oil 25-29mL, walnut oil 1-5ml, it is preferred that retinol acetate 28.8mg, vitamin D30.288mg、
Ascorbyl palmitate 12mg, corn oil 29mL, walnut oil 1ml.
The present invention also provides the preparation methods of said vitamin class drops, and steps are as follows:
(1) raw material is weighed；
(2) corn oil is divided into three parts, 70-90 DEG C of ascorbyl palmitate is dissolved by heating in first portion of corn oil
In, mixed liquor one is obtained, it is spare, the ultrasonic dissolution into second portion of corn oil is added in vitamin, obtains mixed liquor two, wherein
First portion of corn oil accounts for the 10-40% of corn oil gross mass, and second portion of corn oil accounts for the 20-40% of corn oil gross mass；
(3) mixed liquor one, mixed liquor two, walnut oil and third part corn oil are mixed, stirs, obtains at 18-26 DEG C
The sieving of lysate 100-150 mesh screen, collection obtain filtrate；
(4) filtrate is filling into Packaging Bottle, it seals to get vitamins drops.
Vitamin and ascorbyl palmitate are dissolved in corn oil and walnut oil by the present invention, and in suitable temperature range
It inside stirs evenly, increases the solubility of vitamin in a solvent, reach a dissolution equilibrium, will not influence vitamin in solvent
In stability and dissolubility, and preparation method is simple and easy to operate, mild condition, will not pollute, and is suitble to large-scale production.
Further, the concrete operations of step (4) are as follows: using after automatic bottle washing machine purged and packed bottle by the filter in step (3)
Liquid is filling to indicate the 95% of loading amount into Packaging Bottle, the loading amount in each Packaging Bottle is no less than, and average loading amount no less than indicates dress
Amount, screws, up to vitamins drops after sealing.
Further, retinol acetate carries out 50-60 DEG C of water-bath to nodeless mesh in advance.
Further, Packaging Bottle is soda-lime glass bottle.
Vitamins drops specification after the present invention is filling is 30mL/ bottles, and every bottle contains: 7200 μ g of vitamin A, vitamin
D3240 μ g, are applicable to replenishing vitamins A, vitamin D31-6 years old crowd.
Amount and eating method are as follows: one time a day, 30 drop, eating method: draws liquid to 1ml with matched dropper every time
At graduation mark (every milliliter be equivalent to 30 drops be laboratory repeatedly measure after average value, by dynamics, angle for using dropper etc. because
Element influences, and the number of drops of each dropper release might have certain deviation, as long as guaranteeing that liquid draw physical efficiency reaches 1mL quarter when edible
Can guarantee that each amount is identical at degree line), in direct housing instills mouth, or it is added in other foods and eats.
Store method are as follows: seal, be protected from light, setting at shady and cool drying, can be reserved for 24 months.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
In the examples below, vitamin D3Meet vitamin D in the Pharmacopoeia of the People's Republic of China3Regulation；Corn oil
Meet the regulation of GB/T 19111 " corn oil "；Walnut oil meets the regulation of GB/T 22327 " walnut oil "；Ascorbic acid palm
Acid esters meets the regulation of GB 1886.230 " national food safety standard food additives ascorbyl palmitate "；
The molding medicine bottle of soda-lime glass used by packing meets " soda-lime glass molding medicine bottle " (YBB00272002-2015)
In regulation；Bottle cap meets in " national food safety standard food contact plastic material and product " (GB 4806.7-2016)
Regulation；
Content uniformity index meets in the Pharmacopoeia of the People's Republic of China under " rules of preparations " item that " oral solution is oral mixed
The regulation of suspension Orally taken emulsion " and " 0942 Minimum loading capacity examination method of general rule ".
Embodiment 1
Vitamins drops contains in every 30ml drops: vitamin D30.432mg, ascorbyl palmitate 12mg, jade
Rice bran oil 29mL, walnut oil 1ml；
Steps are as follows for preparation method:
(1) raw material is weighed；
(2) corn oil is divided into three parts, 80 DEG C of ascorbyl palmitate is dissolved by heating in first portion of corn oil, is obtained
It is spare to mixed liquor one, by vitamin D3The ultrasonic dissolution into second portion of corn oil is added, obtains mixed liquor two, wherein first
Part corn oil accounts for the 10% of corn oil gross mass, and second portion of corn oil accounts for the 40% of corn oil gross mass；
(3) mixed liquor one, mixed liquor two, walnut oil and third part corn oil are mixed, stirs, is dissolved at 20 DEG C
The sieving of 150 mesh screen of liquid, collection obtain filtrate；
(4) using filtrate is filling into soda-lime glass bottle, each Packaging Bottle after automatic bottle washing machine cleaning soda-lime glass bottle
Interior loading amount, which is no less than, indicates the 95% of loading amount, and average loading amount no less than indicates loading amount, screws, and drips after sealing up to vitamins
Agent；
By the drops packaging after sealing, quality inspection is carried out by drops product technology requirement, is put in storage after the assay was approved, close
Seal, be protected from light, set at shady and cool dry under conditions of save.
Embodiment 2
Vitamins drops contains in every 30ml drops: retinol acetate 28.8mg, vitamin D30.288mg, Vitamin C
Sour palmitate 12mg, corn oil 29mL, walnut oil 1ml.
Steps are as follows for preparation method:
(1) raw material is weighed, it is spare to nodeless mesh that retinol acetate is carried out 50 DEG C of water-baths；
(2) corn oil is divided into three parts, 70 DEG C of ascorbyl palmitate is dissolved by heating in first portion of corn oil, is obtained
It is spare to mixed liquor one, by retinol acetate and vitamin D3The ultrasonic dissolution into second portion of corn oil is added, obtains mixed liquor
Two, wherein first portion of corn oil accounts for the 30% of corn oil gross mass, and second portion of corn oil accounts for the 30% of corn oil gross mass；
(3) mixed liquor one, mixed liquor two, walnut oil and third part corn oil are mixed, stirs, is dissolved at 22 DEG C
The sieving of 150 mesh screen of liquid, collection obtain filtrate；
(4) using after automatic bottle washing machine cleaning soda-lime glass molding medicine bottle that filtrate is filling to soda-lime glass molding medicine bottle
In, the loading amount in each Packaging Bottle, which is no less than, indicates the 95% of loading amount, and average loading amount no less than indicates loading amount, screws, after sealing
Up to vitamins drops；
By the drops packaging after sealing, quality inspection is carried out by drops product technology requirement, is put in storage after the assay was approved, close
Seal, be protected from light, set at shady and cool dry under conditions of save.
Embodiment 3
Vitamins drops contains in every 30ml drops: vitamin D30.40mg, ascorbyl palmitate 10mg, jade
Rice bran oil 25mL, walnut oil 5ml；
Steps are as follows for preparation method:
(1) raw material is weighed；
(2) corn oil is divided into three parts, 75 DEG C of ascorbyl palmitate is dissolved by heating in first portion of corn oil, is obtained
It is spare to mixed liquor one, by vitamin D3The ultrasonic dissolution into second portion of corn oil is added, obtains mixed liquor two, wherein first
Part corn oil accounts for the 10% of corn oil gross mass, and second portion of corn oil accounts for the 40% of corn oil gross mass；
(3) mixed liquor one, mixed liquor two, walnut oil and third part corn oil are mixed, stirs, is dissolved at 18 DEG C
The sieving of 100 mesh screen of liquid, collection obtain filtrate；
(4) using after automatic bottle washing machine cleaning soda-lime glass molding medicine bottle that filtrate is filling to soda-lime glass molding medicine bottle
In, the loading amount in each Packaging Bottle, which is no less than, indicates the 95% of loading amount, and average loading amount no less than indicates loading amount, screws, after sealing
Up to vitamins drops；
By the drops packaging after sealing, quality inspection is carried out by drops product technology requirement, is put in storage after the assay was approved, close
Seal, be protected from light, set at shady and cool dry under conditions of save.
Embodiment 4
Vitamins drops contains in every 30ml drops: vitamin D30.45mg, ascorbyl palmitate 15mg, jade
Rice bran oil 29mL, walnut oil 1ml；
Steps are as follows for preparation method:
(1) raw material is weighed；
(2) corn oil is divided into three parts, 90 DEG C of ascorbyl palmitate is dissolved by heating in first portion of corn oil, is obtained
It is spare to mixed liquor one, by vitamin D3The ultrasonic dissolution into second portion of corn oil is added, obtains mixed liquor two, wherein first
Part corn oil accounts for the 40% of corn oil gross mass, and second portion of corn oil accounts for the 30% of corn oil gross mass；
(3) mixed liquor one, mixed liquor two, walnut oil and third part corn oil are mixed, stirs, is dissolved at 26 DEG C
The sieving of 100 mesh screen of liquid, collection obtain filtrate；
(4) using after automatic bottle washing machine cleaning soda-lime glass molding medicine bottle that filtrate is filling to soda-lime glass molding medicine bottle
In, the loading amount in each Packaging Bottle, which is no less than, indicates the 95% of loading amount, and average loading amount no less than indicates loading amount, screws, after sealing
Up to vitamins drops；
By the drops packaging after sealing, quality inspection is carried out by drops product technology requirement, is put in storage after the assay was approved, close
Seal, be protected from light, set at shady and cool dry under conditions of save.
Embodiment 5
Vitamins drops contains in every 30ml drops: retinol acetate 28mg, vitamin D30.01mg, ascorbic acid
Palmitate 10mg, corn oil 25mL, walnut oil 5ml；
Steps are as follows for preparation method:
(1) raw material is weighed, it is spare to nodeless mesh that retinol acetate is carried out 60 DEG C of water-baths；
(2) corn oil is divided into three parts, 80 DEG C of ascorbyl palmitate is dissolved by heating in first portion of corn oil, is obtained
It is spare to mixed liquor one, by retinol acetate and vitamin D3The ultrasonic dissolution into second portion of corn oil is added, obtains mixed liquor
Two, wherein first portion of corn oil accounts for the 40% of corn oil gross mass, and second portion of corn oil accounts for the 40% of corn oil gross mass；
(3) mixed liquor one, mixed liquor two, walnut oil and third part corn oil are mixed, stirs, is dissolved at 24 DEG C
The sieving of 100 mesh screen of liquid, collection obtain filtrate；
(4) using after automatic bottle washing machine cleaning soda-lime glass molding medicine bottle that filtrate is filling to soda-lime glass molding medicine bottle
In, the loading amount in each Packaging Bottle, which is no less than, indicates the 95% of loading amount, and average loading amount no less than indicates loading amount, screws, after sealing
Up to vitamins drops；
By the drops packaging after sealing, quality inspection is carried out by drops product technology requirement, is put in storage after the assay was approved, close
Seal, be protected from light, set at shady and cool dry under conditions of save.
Embodiment 6
Vitamins drops contains in every 30ml drops: retinol acetate 32mg, vitamin D30.05mg, ascorbic acid
Palmitate 15mg, corn oil 29mL, walnut oil 1ml；
Steps are as follows for preparation method:
(1) raw material is weighed, it is spare to nodeless mesh that retinol acetate is carried out 50 DEG C of water-baths；
(2) corn oil is divided into three parts, 90 DEG C of ascorbyl palmitate is dissolved by heating in first portion of corn oil, is obtained
It is spare to mixed liquor one, by retinol acetate and vitamin D3The ultrasonic dissolution into second portion of corn oil is added, obtains mixed liquor
Two, wherein first portion of corn oil accounts for the 20% of corn oil gross mass, and second portion of corn oil accounts for the 30% of corn oil gross mass；
(3) mixed liquor one, mixed liquor two, walnut oil and third part corn oil are mixed, stirs, is dissolved at 22 DEG C
The sieving of 120 mesh screen of liquid, collection obtain filtrate；
(4) using after automatic bottle washing machine cleaning soda-lime glass molding medicine bottle that filtrate is filling to soda-lime glass molding medicine bottle
In, the loading amount in each Packaging Bottle, which is no less than, indicates the 95% of loading amount, and average loading amount no less than indicates loading amount, screws, after sealing
Up to vitamins drops；
By the drops packaging after sealing, quality inspection is carried out by drops product technology requirement, is put in storage after the assay was approved, close
Seal, be protected from light, set at shady and cool dry under conditions of save.
Performance test
Preparation-obtained vitamins drops carries out performance evaluation, assessment item in difference Example 1 and embodiment 2
And result such as following table 1-4.
Vitamins drops organoleptic indicator and evaluation in 1 embodiment 1,2 of table
| Project | Index | Embodiment 1 | Embodiment 2 |
| Color | It is faint yellow to yellow | Meet index | Meet index |
| Flavour, smell | With the distinctive flavour of this product and smell, free from extraneous odour | Meet index | Meet index |
| State | Clear oil liquid, the visible alien material of no twenty-twenty vision | Meet index | Meet index |
Vitamins drops physical and chemical index and evaluation in 2 embodiment 1,2 of table
| Project | Index | The method of inspection | Embodiment 1 | Embodiment 2 |
| Lead (in terms of Pb), mg/kg | ≤0.02 | GB5009.12 | It is not detected | It is not detected |
| Total arsenic (in terms of As), mg/kg | ≤0.3 | GB5009.11 | It is not detected | It is not detected |
| Total mercury (in terms of Hg), mg/kg | ≤0.02 | GB5009.17 | It is not detected | It is not detected |
| Acid value, mg/g | ≤4 | GB5009.229 | 0.4 | 0.38 |
| Peroxide value, g/100g | ≤0.25 | GB5009.227 | 0.028 | 0.024 |
Vitamins drops microbiological indicator and evaluation in 3 embodiment 1,2 of table
The significant component target of vitamins drops and evaluation in 4 embodiment 1,2 of table
Claims (10)
1. a kind of vitamins drops, which is characterized in that contain in the drops: vitamin, ascorbyl palmitate, corn
Oil and walnut oil.
2. a kind of vitamins drops according to claim 1, which is characterized in that the vitamin is vitamin D3Or vinegar
Sour retinyl ester and vitamin D3Mixture.
3. a kind of vitamins drops according to claim 2, which is characterized in that contain in drops described in every 30ml: dimension
Raw element D30.40-0.45mg, ascorbyl palmitate 10-15mg, corn oil 25-29mL, walnut oil 1-5ml.
4. a kind of vitamins drops according to claim 3, which is characterized in that contain in drops described in every 30ml: dimension
Raw element D30.432mg, ascorbyl palmitate 12mg, corn oil 29mL, walnut oil 1ml.
5. a kind of vitamins drops according to claim 2, which is characterized in that contain in drops described in every 30ml: vinegar
Sour retinyl ester 28-32mg, vitamin D30.25-0.30mg, ascorbyl palmitate 10-15mg, corn oil 25-29mL, core
Peach oil 1-5ml.
6. a kind of vitamins drops according to claim 5, which is characterized in that contain in drops described in every 30ml: vinegar
Sour retinyl ester 28.8mg, vitamin D30.288mg, ascorbyl palmitate 12mg, corn oil 29mL, walnut oil 1ml.
7. a kind of preparation method of vitamins drops as claimed in any one of claims 1 to 6, which is characterized in that step is such as
Under:
(1) each raw material is weighed；
(2) corn oil is divided into three parts, ascorbyl palmitate is dissolved by heating in first portion of corn oil, mixed liquor is obtained
One, it is spare, the ultrasonic dissolution into second portion of corn oil is added in vitamin, obtains mixed liquor two；
(3) mixed liquor one, mixed liquor two, walnut oil and third part corn oil are mixed, obtain lysate sieving, collects
To filtrate；
(4) filtrate is filling into Packaging Bottle, it seals to get the vitamins drops.
8. a kind of preparation method of vitamins drops according to claim 7, which is characterized in that described in step (2)
It dissolves by heating to be heated to 70-90 DEG C；
First portion of corn oil accounts for the 10-40% of corn oil gross mass, and second portion of corn oil accounts for the 20- of corn oil gross mass
40%.
9. a kind of preparation method of vitamins drops according to claim 7, which is characterized in that described in step (3)
Stirring is to stir at 18-26 DEG C；
The operation of the sieving is the sieving of 100-150 mesh screen.
10. a kind of preparation method of vitamins drops according to claim 7, which is characterized in that described in step (4)
Packaging Bottle is that soda-lime glass moulds medicine bottle.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110301648A (en) * | 2019-07-24 | 2019-10-08 | 杭州海王生物工程有限公司 | A kind of minerals class drops and preparation method thereof |
| CN111602820A (en) * | 2020-05-28 | 2020-09-01 | 广州富诺营养科技有限公司 | Drop containing vitamin A and vitamin D and its preparation method |
| CN118384283A (en) * | 2024-06-24 | 2024-07-26 | 广州朗圣药业有限公司 | Stable vitamin AD composition, and preparation method, preparation and application thereof |
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| CN1174032A (en) * | 1996-08-15 | 1998-02-25 | 北京三鸣生物工程有限公司 | Compound vitamin drop for infant |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110301648A (en) * | 2019-07-24 | 2019-10-08 | 杭州海王生物工程有限公司 | A kind of minerals class drops and preparation method thereof |
| CN111602820A (en) * | 2020-05-28 | 2020-09-01 | 广州富诺营养科技有限公司 | Drop containing vitamin A and vitamin D and its preparation method |
| CN118384283A (en) * | 2024-06-24 | 2024-07-26 | 广州朗圣药业有限公司 | Stable vitamin AD composition, and preparation method, preparation and application thereof |
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Application publication date: 20191018 |