CN108902986A - A kind of soft capsule and preparation method thereof of replenishing vitamins AD - Google Patents
A kind of soft capsule and preparation method thereof of replenishing vitamins AD Download PDFInfo
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- CN108902986A CN108902986A CN201810789223.9A CN201810789223A CN108902986A CN 108902986 A CN108902986 A CN 108902986A CN 201810789223 A CN201810789223 A CN 201810789223A CN 108902986 A CN108902986 A CN 108902986A
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- soft capsule
- replenishing vitamins
- feed liquid
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- 239000011782 vitamin Substances 0.000 title claims abstract description 80
- 229940088594 vitamin Drugs 0.000 title claims abstract description 79
- 229930003231 vitamin Natural products 0.000 title claims abstract description 79
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 79
- 239000007901 soft capsule Substances 0.000 title claims abstract description 73
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 33
- 239000002775 capsule Substances 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000008213 purified water Substances 0.000 claims abstract description 19
- 239000011647 vitamin D3 Substances 0.000 claims abstract description 19
- 239000000203 mixture Substances 0.000 claims abstract description 14
- 239000003921 oil Substances 0.000 claims abstract description 14
- 102000002322 Egg Proteins Human genes 0.000 claims abstract description 13
- 108010000912 Egg Proteins Proteins 0.000 claims abstract description 13
- 235000019169 all-trans-retinol Nutrition 0.000 claims abstract description 13
- 239000011717 all-trans-retinol Substances 0.000 claims abstract description 13
- 235000013345 egg yolk Nutrition 0.000 claims abstract description 13
- 210000002969 egg yolk Anatomy 0.000 claims abstract description 13
- 239000008170 walnut oil Substances 0.000 claims abstract description 12
- 108010010803 Gelatin Proteins 0.000 claims abstract description 11
- 229920000159 gelatin Polymers 0.000 claims abstract description 11
- 239000008273 gelatin Substances 0.000 claims abstract description 11
- 235000019322 gelatine Nutrition 0.000 claims abstract description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 11
- 235000019498 Walnut oil Nutrition 0.000 claims abstract description 9
- 235000019198 oils Nutrition 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 43
- 239000006041 probiotic Substances 0.000 claims description 27
- 235000018291 probiotics Nutrition 0.000 claims description 27
- 238000000855 fermentation Methods 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 241000894006 Bacteria Species 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 240000006024 Lactobacillus plantarum Species 0.000 claims description 9
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 9
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 9
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 8
- 241001608472 Bifidobacterium longum Species 0.000 claims description 8
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims description 8
- 229940009291 bifidobacterium longum Drugs 0.000 claims description 8
- 238000000748 compression moulding Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 230000004151 fermentation Effects 0.000 claims description 7
- 238000010792 warming Methods 0.000 claims description 6
- 235000013351 cheese Nutrition 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 5
- 239000004310 lactic acid Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000084 colloidal system Substances 0.000 claims description 2
- 238000010790 dilution Methods 0.000 claims description 2
- 239000012895 dilution Substances 0.000 claims description 2
- 238000011081 inoculation Methods 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 28
- 229910052791 calcium Inorganic materials 0.000 abstract description 28
- 239000011575 calcium Substances 0.000 abstract description 28
- 206010016256 fatigue Diseases 0.000 abstract description 14
- 230000003185 calcium uptake Effects 0.000 abstract description 9
- 206010006956 Calcium deficiency Diseases 0.000 abstract description 3
- 230000003860 sleep quality Effects 0.000 abstract description 3
- 241000700159 Rattus Species 0.000 description 17
- 238000011049 filling Methods 0.000 description 15
- 230000037182 bone density Effects 0.000 description 14
- 210000000988 bone and bone Anatomy 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 10
- 235000021590 normal diet Nutrition 0.000 description 10
- 210000000689 upper leg Anatomy 0.000 description 9
- 230000012010 growth Effects 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 7
- 239000000839 emulsion Substances 0.000 description 7
- 230000001954 sterilising effect Effects 0.000 description 6
- 235000005282 vitamin D3 Nutrition 0.000 description 6
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 6
- 229940021056 vitamin d3 Drugs 0.000 description 6
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 229930003316 Vitamin D Natural products 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 235000019166 vitamin D Nutrition 0.000 description 4
- 239000011710 vitamin D Substances 0.000 description 4
- 150000003710 vitamin D derivatives Chemical class 0.000 description 4
- 229940046008 vitamin d Drugs 0.000 description 4
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 230000036417 physical growth Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 210000001694 thigh bone Anatomy 0.000 description 3
- 235000019155 vitamin A Nutrition 0.000 description 3
- 239000011719 vitamin A Substances 0.000 description 3
- 229940045997 vitamin a Drugs 0.000 description 3
- 244000144730 Amygdalus persica Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- UCTLRSWJYQTBFZ-UHFFFAOYSA-N Dehydrocholesterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCCC(C)C)CCC33)C)C3=CC=C21 UCTLRSWJYQTBFZ-UHFFFAOYSA-N 0.000 description 2
- 235000006040 Prunus persica var persica Nutrition 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- UCTLRSWJYQTBFZ-DDPQNLDTSA-N cholesta-5,7-dien-3beta-ol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@H](C)CCCC(C)C)CC[C@H]33)C)C3=CC=C21 UCTLRSWJYQTBFZ-DDPQNLDTSA-N 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- MRELNEQAGSRDBK-UHFFFAOYSA-N lanthanum(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[La+3].[La+3] MRELNEQAGSRDBK-UHFFFAOYSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 229960003471 retinol Drugs 0.000 description 2
- 235000020944 retinol Nutrition 0.000 description 2
- 239000011607 retinol Substances 0.000 description 2
- 108010048734 sclerotin Proteins 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 description 1
- GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 description 1
- JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 description 1
- 239000003872 25-hydroxy-cholecalciferol Substances 0.000 description 1
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 description 1
- 208000000412 Avitaminosis Diseases 0.000 description 1
- 235000021318 Calcifediol Nutrition 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010021135 Hypovitaminosis Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- YUGCAAVRZWBXEQ-UHFFFAOYSA-N Precholecalciferol Natural products C=1CCC2(C)C(C(C)CCCC(C)C)CCC2C=1C=CC1=C(C)CCC(O)C1 YUGCAAVRZWBXEQ-UHFFFAOYSA-N 0.000 description 1
- NCYCYZXNIZJOKI-OVSJKPMPSA-N Retinaldehyde Chemical compound O=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 206010047626 Vitamin D Deficiency Diseases 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- JWUBBDSIWDLEOM-DTOXIADCSA-N calcidiol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DTOXIADCSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 238000001739 density measurement Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000021332 multicellular organism growth Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 208000005368 osteomalacia Diseases 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 235000020945 retinal Nutrition 0.000 description 1
- 239000011604 retinal Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 208000030401 vitamin deficiency disease Diseases 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 238000000209 wet digestion Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses the soft capsules of replenishing vitamins AD a kind of, including content and capsule shells, and by weight, the content includes 0.1~2.5 part of oleovitamin A, vitamin D30.1~0.75 part of oil, 200~350 parts of walnut oil, 10~50 parts of mash and 10~20 parts of egg yolk, the capsule shells include 60~150 parts of gelatin, 60~150 parts of purified water and 20~65 parts of glycerol.The invention also discloses a kind of preparation methods of the soft capsule of replenishing vitamins AD.The soft capsule of replenishing vitamins AD of the present invention has many advantages, such as to improve teenager's calcium deficiency situation and prevents middle-aged and the old's calcium loss, promotes calcium uptake and is converted into composition calcium, the sleep quality for improving calcium loss patient, fatiguability situation.
Description
Technical field
The present invention relates to the soft of functional health-care food and field of pharmaceutical technology more particularly to a kind replenishing vitamins AD
Capsule and preparation method thereof.
Background technique
Vitamin A (vitaminA) is also known as retinol (its aldehyde derivatives retinene) or antiophthalmic factor, is a tool
There is the unsaturated monohydric alcohol of alicyclic ring, two kinds of retinol1, A2 including animal food source are a kind of with retinol biology
Active substance.Vitamin A and normal vision have substantial connection, required for bone normal growth, facilitate the hyperplasia of cell
With growth, and epithelial cell is normally formed, develop and is maintained is particularly significant.
Vitamin D3 (also known as vitamine D3 or cholecalciferol) is one kind of vitamin D, is generated after cholesterol dehydrogenation
7-DHC can form Vitamin D3 through ultraviolet light irradiation, therefore that is the provitamin D of Vitamin D3 is
7-DHC.Vitamin D3 in liver through be hydroxylated enzyme system act on forming 25-hydroxycholecalciferol, then in kidney it is hydroxylated
It is 1, the activity of 1, 25-dihydroxycholecalciferol, this substance is high compared with Vitamin D3 by 50%, is proved to be vitamin D in vivo true
Positive active form.Vitamin D deficiency will lead to juvenile's rickets and adult's osteomalacia.
In the modern life, as people's diet increasingly refines, the process of numerous food product is all stripped of big portion
The finishing passes of the vitamin component, such as rice, wheat divided etc., have been further exacerbated by vitamin-deficiency.The prior art
In some vitamin AD tonic use soybean oil as matrix, nutritional ingredient is less, be unable to satisfy the modern life for dimension
The demand of raw element.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide the flexible glues of replenishing vitamins AD a kind of
Capsule,
The second object of the present invention is to provide a kind of preparation method of the soft capsule of replenishing vitamins AD,
An object of the present invention adopts the following technical scheme that realization：
A kind of soft capsule of replenishing vitamins AD, including content and capsule shells, by weight, the content includes
0.1~2.5 part of oleovitamin A, vitamin D3Oil 0.1~0.75 part, 200~350 parts of walnut oil, 10~50 parts of mash and
10~20 parts of egg yolk, the capsule shells include 60~150 parts of gelatin, 60~150 parts of purified water and 20~65 parts of glycerol.
Further, the oleovitamin A is 0.5~1 part, the vitamin D3Oil is 0.15~0.25 part, the core
Peach oil is 280~320 parts, and the mash is 20~40 parts, and the egg yolk is 12~16 parts, and the gelatin is 90~120
Part, the purified water is 90~120 parts, and the glycerol is 30~50 parts.
Further, the oleovitamin A is 0.75 part, the vitamin D3Oil is 0.22 part, and the walnut oil is
299.03 parts, the mash is 25 parts, and the egg yolk is 14 parts, and the gelatin is 108 parts, and the purified water is 102 parts,
The glycerol is 45 parts.
The second object of the present invention adopts the following technical scheme that realization：
The preparation method of the soft capsule of above-mentioned replenishing vitamins AD, includes the following steps：
Prepare content feed liquid：By oleovitamin A, vitamin D3Walnut oil is added in oil and egg yolk after mixing, stirs
It mixes and is warming up to 60~80 DEG C, addition mash after being uniformly mixed, crosses colloid mill 2~3 times, vacuumizes, crosses 80~120
Content feed liquid is made in mesh；
Prepare capsule shells feed liquid：It is pre-mixed glycerol and purified water and is warming up to 70~90 DEG C, then gelatin is added thereto,
It stirs and evenly mixs, vacuumize at 70~90 DEG C, crossing 80~120 meshes, capsule shells feed liquid is made；
Compression moulding：Capsule shells feed liquid and content material liquid compression moulding are taken, the soft capsule of replenishing vitamins AD is made.
Further, it prepares in content feed liquid step, by oleovitamin A, vitamin D3Oil and egg yolk are uniformly mixed
After walnut oil is added, stir and mash be added after being warming up to 70 DEG C.
Further, further include probiotics fermention step, purified water dilution is added into content feed liquid obtained, it will be dilute
The content feed liquid released is transferred to curing at 105~121 DEG C, 5~15min of sterilizing, and cooled to room temperature is inoculated with probiotics
Anaerobic fermentation 5~10 days under the conditions of 1~5 part, 35~40 DEG C, after anaerobic fermentation, concentrated broth is stand-by；
Wherein, the weight ratio of content feed liquid and purified water is 1:1~5, anaerobic fermentation is in the process at interval of 6~12h
It is primary to stir content feed liquid；And
The probiotics are at least one of Lactobacillus rhamnosus, cheese lactic acid bacteria and lactobacillus plantarum and Bao Jiali
The mix bacterium agent of sub- bacillus and bifidobacterium longum composition.
Further, the probiotics are Lactobacillus rhamnosus, lactobacillus plantarum, bacillus bulgaricus and long bifid bar
The mix bacterium agent of bacterium composition, the probiotics are 2~3 parts；
Wherein, the ratio of number of Lactobacillus rhamnosus, lactobacillus plantarum, bacillus bulgaricus and bifidobacterium longum is 1:
1~5:1:1~5.
Further, the weight ratio of the content feed liquid and purified water is 1:2, the probiotics are 3 parts, 38 DEG C
Under the conditions of anaerobic fermentation 7 days；
The fermentation liquid is concentrated into water content lower than 25%.
Compared with prior art, the beneficial effects of the present invention are：
(1) a kind of soft capsule of replenishing vitamins AD of the present invention has compared to traditional kind replenishing vitamins AD soft capsule
The features such as absorptivity is high, bioavailability is high, is embodied in：It is convenient when use, after body is taken, there is calcium absorption rate
Feature high, bioavailability is high, is embodied in：Promote the growth of body height, meanwhile, promote body weight gain, makes
With the soft capsule of replenishing vitamins AD prepared by the present invention can be obviously improved femur weight, calcium content of bone, midpoint bone density and
Distal end bone density improves teenager's calcium deficiency situation and prevents middle-aged and the old's calcium loss, promotes calcium uptake and is converted into composition calcium.
The soft capsule of replenishing vitamins AD of the present invention also has the sleep quality for significantly improving calcium loss patient, fatiguability situation etc. excellent
Point.
(2) a kind of preparation method of the soft capsule of replenishing vitamins AD of the present invention has preparation process simple, at low cost, side
Just it is mass produced, the soft capsule of the replenishing vitamins AD prepared by this method can remarkably promote physical growth, promote calcium
It absorbs, improves sleep quality and fatiguability situation.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
Hereinafter, illustrating the preparation process of the soft capsule of replenishing vitamins AD of the present invention by embodiment 1~12.
Embodiment 1-6 is the soft capsule of 6 kinds of different replenishing vitamins AD, this 6 kinds different replenishing vitamins AD's is soft
The preparation process of capsule includes preparing content feed liquid step, preparation capsule shells feed liquid step and compression moulding step.This 6 kinds
The difference of the preparation process of the soft capsule of different replenishing vitamins AD is only that the difference of raw material proportioning and technological parameter.
Prepare content feed liquid step：By oleovitamin A, vitamin D3Oil is added in emulsion pot, and 5~10min of stirring is extremely
It mixes, egg yolk is added into emulsion pot, equally 5~10min of stirring to mixing, then walnut oil is added into emulsion pot, it stirs
And it is warming up to uniformly mixed, mash is added under the conditions of remaining temperature-resistant, after being uniformly mixed, mixed component is taken out true
Empty, sieving, is made content feed liquid.Oleovitamin A, vitamin D3Oil, mash, the dosage and core of walnut oil and egg yolk
The temperature of peach oil is shown in Table 1.
Table 1
Prepare capsule shells feed liquid step：Glycerol and purified water are added in emulsion pot in advance and stirred and evenly mixed, emulsion pot liter
It keeps emulsion pot temperature-resistant after temperature, then gelatin is added into emulsion pot, quickly stir and evenly mix, vacuumize, be sieved, capsule is made
Shell feed liquid.Glycerol, the dosage of purified water and gelatin and emulsification pot temperature are referring to table 2.
Table 2
Compression moulding step：Machine, debugging machine parameter in the capsule shells feed liquid and content feed liquid of above-mentioned preparation are simultaneously led to
Pressing compression moulding is crossed, the soft capsule of replenishing vitamins AD is made, the weight of the soft capsule of replenishing vitamins AD is substantially
0.3g/.
Embodiment 7-12 is the soft capsule of other 6 kinds different replenishing vitamins AD, this 6 kinds different replenishing vitamins AD
Soft capsule preparation process include prepare content feed liquid step, probiotics fermention step, preparation capsule shells feed liquid step
With compression moulding step.The difference of embodiment 7 and embodiment 1 is only that probiotics fermention step；Embodiment 8 and embodiment 2
Difference is only that probiotics fermention step；The difference of embodiment 9 and embodiment 3 is only that probiotics fermention step；Embodiment 10
Difference with embodiment 4 is only that probiotics fermention step；The difference of embodiment 11 and embodiment 5 is only that probiotics fermention walks
Suddenly；The difference of embodiment 12 and embodiment 6 is only that probiotics fermention step.
Probiotics fermention step：Purified water is added into content feed liquid obtained to be diluted, and is stirred evenly, will be diluted
Content feed liquid be transferred in high-temperature sterilization pot and cured, sterilized, after the completion of sterilizing, content feed liquid is transferred to sterile
Under the conditions of cooled to room temperature.Cooling content feed liquid inoculation probiotics simultaneously carry out anaerobic fermentation, anaerobic fermentation process
In at interval of certain time stirring content feed liquid it is primary.After anaerobic fermentation, extremely by Rotary Evaporators concentrated broth
Water content is lower than 25%, and the content feed liquid of fermentation is made.Wherein, the weight ratio (material-water ratio) of content feed liquid and purified water,
The sterilising temp of high-temperature sterilization pot, sterilization time, the inoculum concentration of probiotics, the temperature of anaerobic fermentation, anaerobic fermentation time,
The bath temperature of interval time and Rotary Evaporators is stirred referring to table 3.
Table 3
In above-mentioned table 3, mix bacterium agent be Lactobacillus rhamnosus agent, cheese agent of lactic acid bacteria and lactobacillus plantarum agent at least
A kind of compound probiotic agent formed with bacillus bulgaricus agent and bifidobacterium longum agent.Wherein, mouse in Lactobacillus rhamnosus agent
The quantity of cheese lactic acid bacteria in the quantity of Lee's sugar lactobacillus, cheese agent of lactic acid bacteria, in lactobacillus plantarum agent lactobacillus plantarum number
Amount, the quantity of bacillus bulgaricus in bacillus bulgaricus agent, in bifidobacterium longum agent the quantity of bifidobacterium longum be 4 ×
106A/g.
The recruitment evaluation of the soft capsule of replenishing vitamins AD
Materials and methods
Tested material：The soft capsule of the replenishing vitamins AD of embodiment 1-12 preparation, food ration press 180mg replenishing vitamins AD
The every 60kg adult's batheroom scale of soft capsule, can convert as 30mg/kgBW, sample (being doped in feed) is given in a manner of stomach-filling.
Experimental animal：Cleaning grade SD kind healthy rat 130,75~85g of weight, by Nanfang Medical Univ experimental animal
The heart provides.
Medication：After rat adaptable fed 3d, 13 groups are randomly divided into, every group 10, respectively (stomach-filling is general for control group
Logical feed), experimental group A (normal diet of the soft capsule for the replenishing vitamins AD that stomach-filling is prepared doped with embodiment 1), experimental group
B (normal diet of the soft capsule for the replenishing vitamins AD that stomach-filling is prepared doped with embodiment 2), (stomach-filling is doped with reality by experimental group C
Apply example 3 preparation replenishing vitamins AD soft capsule normal diet), the experimental group D (benefit that stomach-filling is prepared doped with embodiment 4
Fill the normal diet of the soft capsule of vitaminAD), (the replenishing vitamins AD's that stomach-filling is prepared doped with embodiment 5 is soft by experimental group E
The normal diet of capsule), experimental group F (the common feeding of the soft capsule for the replenishing vitamins AD that stomach-filling is prepared doped with embodiment 6
Material), experimental group G (normal diet of the soft capsule for the replenishing vitamins AD that stomach-filling prepare doped with embodiment 7), experimental group H (filling
The normal diet of the soft capsule for the replenishing vitamins AD that stomach is prepared doped with embodiment 8), (stomach-filling is doped with embodiment by experimental group I
The normal diet of the soft capsule of the replenishing vitamins AD of 9 preparations), experimental group J (the supplement dimension that stomach-filling prepare doped with embodiment 10
The normal diet of the soft capsule of raw element AD), the experimental group K (flexible glue for the replenishing vitamins AD that stomach-filling is prepared doped with embodiment 11
The normal diet of capsule), experimental group L (the common feeding of the soft capsule for the replenishing vitamins AD that stomach-filling is prepared doped with embodiment 12
Material).Each daily stomach-filling amount of experimental group rat is the soft capsule that every Kg weight gives 30mg replenishing vitamins AD, continues to feed to 13
Week the femur weight of each group rat, thighbone density and calcium content of bone (including midpoint bone density and distal bone are detected at the end of experiment
Density).
Thighbone density measurement：Thighbone samples are using the measurement midpoint single photon bone density machine (SD-1000) and the bone of distal end
Density.Calcium uptake experiment and calcium content of bone measurement：The right side femur that drying to constant weight is taken to weigh, through mixed acid (nitric acid：Perchloric acid
=4:1) after wet digestion, with 0.5% lanthana solution constant volume, its calcium content is measured using atomic absorption spectrophotometer.
Influence (n=10, x of the soft capsule of 4 replenishing vitamins AD of table to rat femur weight, calcium content of bone and bone density
±s)
Note：* each experimental group is indicated compared with the control group, significant difference (p<0.05)；* indicates each experimental group and control group
Compare, the extremely significant (p of difference<0.01)；Other experimental groups of the # expression in addition to experimental group C are compared with experimental group C, significant difference (p<
0.05)；Other experimental groups of the ## expression in addition to experimental group C are compared with experimental group C, the extremely significant (p of difference<0.01).
As seen from the results in Table 4, experimental group A-L shows as dramatically increasing compared to control group, femur weight, shows to implement
The soft capsule of the replenishing vitamins AD of example 1-12 preparation can be obviously improved the femur weight of rat, rat is promoted to increase, wherein real
Applying a soft capsule of the replenishing vitamins AD of 9-12 preparation can the extremely significant femur weight for promoting rat.In addition, experimental group H-J phase
Than showing as significant difference in experimental group C, wherein the corresponding average femur weight of experimental group I is maximum, the growth rate of rat
Highest, has the effect of best promotion Growth in Rats, and rat resorption rate is higher.
As seen from the results in Table 4, experimental group C, experimental group G-L show as extremely significant increasing compared to control group, calcium content of bone
Add, compared to control group, calcium content of bone shows as dramatically increasing by experimental group A, B, D and E.The result shows that prepared by embodiment 1-6
Replenishing vitamins AD soft capsule compared to without containing replenishing vitamins AD of the present invention soft capsule control group have preferably
Promotion calcium uptake effect, wherein the soft capsule of replenishing vitamins AD prepared by embodiment 3 is to the promotion calcium absorption effect of rat
It is optimal.The soft capsule of the replenishing vitamins AD of embodiment 7-12 preparation is compared to the flexible glue for not containing replenishing vitamins AD of the present invention
The control group of capsule has extremely significant promotion calcium uptake effect, and extremely significant promotion occurs in calcium content of bone.Embodiment 7-12 preparation
Replenishing vitamins AD soft capsule of the soft capsule compared to the embodiment 1-6 replenishing vitamins AD prepared, have more preferably promote
Into calcium uptake and it is converted into the effect of sclerotin calcium (i.e. composition calcium).Calcium content of bone table compared with experimental group C, in experimental group I, J
Now rise to be significant, have the function of advantageously promoting calcium uptake and is converted into sclerotin calcium (i.e. composition calcium).It follows that real
Apply soft capsule tool of the soft capsule of the replenishing vitamins AD of 7-12 preparation compared to the embodiment 1-6 replenishing vitamins AD prepared
There is better bioavilability.
Similarly, as seen from the results in Table 4, experimental group A-L shows as extremely significant increasing compared to control group, midpoint bone density
Add, shows the extremely significant femur weight for promoting rat of soft capsule energy of the replenishing vitamins AD of embodiment 1-12 preparation, promote big
Mouse growth.Experimental group I, experimental group J (are increased significant) compared to experimental group C, midpoint bone density significant difference.Show compared to reality
The soft capsule of the replenishing vitamins AD of the preparation of example 3 is applied, the soft capsule of replenishing vitamins AD prepared by embodiment 9 and embodiment 10 is equal
It can be obviously improved midpoint bone density, promote rat body growth.
As seen from the results in Table 4, compared to control group, the distal end bone density of experimental group A-L shows as extremely significant increase, table
The soft capsule of the replenishing vitamins AD of bright embodiment 1-12 preparation is compared to the soft capsule for not containing replenishing vitamins AD of the present invention
Control group can it is extremely significant promoted rat distal end bone density, promote Organism of Rats growth, promote calcium absorption.Wherein, it tests
I, J are compared to experimental group C for group, and distal bone density variation is extremely significant, shows as the extremely significant raising of distal end bone density；Experimental group H
Compared to experimental group C, distal bone density variation is significant, shows as the significant raising of distal end bone density.The above results show：Implement
Soft capsule of the soft capsule compared to replenishing vitamins AD prepared by embodiment 3 of the replenishing vitamins AD of example 7-12 preparation has more
The good effect for promoting calcium uptake efficiency and promoting physical growth, wherein replenishing vitamins AD's prepared by embodiment 9
The growth promotion of soft capsule, rush calcium uptake effect are best.
Improve the assessment of fatigue and sleep state
Random storage 150 is diagnosed as the calcium loss gerontal patient of senile calcium deficiency, is randomly divided into three groups：Control group is not sent out
Fermentation capsule group and fermentation Capsules group.It counts 150 calcium loss gerontal patients and is receiving pretherapy and post-treatment fatiguability degree, sleep shape
Condition.Treatment method：The patient for Capsules group of the not fermenting replenishing vitamins AD's that daily morning and evening prepared by each primary oral embodiment 3 is soft
Capsule one, Capsules group of fermenting the patient replenishing vitamins AD that daily morning and evening prepared by each primary oral embodiment 9 soft capsule
One, the patient of control group do as usual diet, continue two months.Specifically fatiguability degree assessment method is：150 patients receive to control
It treats front and back to be both required to continuously read novel 1h, the fatigue conditions of patient is consulted after reading.Degree of fatigue includes：It is very tired
Labor, feeling of fatigue be significant, slightly fatigue, energetic four grades.Statistical result is shown in Table 5.Specifically sleep state appraisal procedure is：
Night wake up 5 times or more (i.e. intermittent sleep) or be difficult to the person of falling asleep be calculated as that sleep is poor, night wakes up 3-4 times and be calculated as sleeping compared with
Difference, night wake up 1-2 time be calculated as sleep generally, night sufficient uninterrupted sleep is calculated as sleeping excellent, four grades totally.Statistical result is shown in Table
6。
Table 5
As shown in table 5, the soft capsule of the replenishing vitamins AD prepared compared to calcium carbonate control group, embodiment 3 and implementation
The soft capsule of replenishing vitamins AD prepared by example 9 can significantly improve the fatiguability situation of calcium loss gerontal patient, wherein pass through
The soft capsule of replenishing vitamins AD after probiotics fermention has the effect of preferably improving fatiguability situation.
Table 6
As shown in table 6, prepared by the soft capsule and embodiment 9 of the replenishing vitamins AD prepared compared to control group, embodiment 3
The soft capsule of replenishing vitamins AD can significantly improve the sleep state of calcium loss gerontal patient, wherein sent out by probiotics
The soft capsule of replenishing vitamins AD after ferment has the effect of preferably improving sleep state.
In conclusion include probiotics fermention step preparation replenishing vitamins AD soft capsule bioavilability,
Improve sleep, improve fatiguability situation etc. shows more preferably effect, this may be produced with probiotics fermention process
Multiple beneficial metabolin is related, such as multivitamin (including vitamin D, vitamin K), macromolecular polysaccharide, amino acid, insatiable hunger
With fatty acid etc., vitamin A, vitamin D are assisted3Absorption.On the one hand these beneficial metabolites and beneficial flora can change
Ecological microenvironment in the enteron aisle of kind rat promotes body immune level, improves sleep and improves fatiguability situation；On the other hand,
These beneficial metabolites can also promote body abilities of digestive and absorption, promote the bioavilability of calcium, promote body to nutriment
Absorption, and then promote physical growth.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (8)
1. a kind of soft capsule of replenishing vitamins AD, which is characterized in that by weight, described including content and capsule shells
Content includes 0.1~2.5 part of oleovitamin A, vitamin D3Oily 0.1~0.75 part, 200~350 parts of walnut oil, mash 10
~50 parts and 10~20 parts of egg yolk, the capsule shells include 60~150 parts of gelatin, 60~150 parts of purified water and glycerol
20~65 parts.
2. the soft capsule of replenishing vitamins AD as described in claim 1, which is characterized in that the oleovitamin A is 0.5~1
Part, the vitamin D3Oil is 0.15~0.25 part, and the walnut oil is 280~320 parts, and the mash is 20~40 parts,
The egg yolk be 12~16 parts, the gelatin be 90~120 parts, the purified water be 90~120 parts, the glycerol be 30~
50 parts.
3. the soft capsule of replenishing vitamins AD as claimed in claim 2, which is characterized in that the oleovitamin A is 0.75 part,
The vitamin D3Oil is 0.22 part, and the walnut oil is 299.03 parts, and the mash is 25 parts, and the egg yolk is 14
Part, the gelatin is 108 parts, and the purified water is 102 parts, and the glycerol is 45 parts.
4. the preparation method of the soft capsule of replenishing vitamins AD as described in any one of claims 1-3, which is characterized in that including
Following steps：
Prepare content feed liquid：By oleovitamin A, vitamin D3Walnut oil is added in oil and egg yolk after mixing, stirs and rises
Mash is added to 60~80 DEG C in temperature, after being uniformly mixed, crosses colloid mill 2~3 times, vacuumizes, crosses 80~120 meshes, system
Obtain content feed liquid；
Prepare capsule shells feed liquid：It is pre-mixed glycerol and purified water and is warming up to 70~90 DEG C, then gelatin is added thereto, 70~
It stirs and evenly mixs, vacuumize at 90 DEG C, crossing 80~120 meshes, capsule shells feed liquid is made；
Compression moulding：Capsule shells feed liquid and content material liquid compression moulding are taken, the soft capsule of replenishing vitamins AD is made.
5. the preparation method of the soft capsule of replenishing vitamins AD as claimed in claim 4, which is characterized in that prepare content material
In liquid step, by oleovitamin A, vitamin D3Walnut oil is added in oil and egg yolk after mixing, stirs and is warming up to 70 DEG C
After mash is added.
6. the preparation method of the soft capsule of replenishing vitamins AD as claimed in claim 4, which is characterized in that further include probiotics
Fermentation step adds purified water dilution into content feed liquid obtained, diluted content feed liquid is transferred to 105~121
It is cured at DEG C, sterilize 5~15min, cooled to room temperature, anaerobic hair under the conditions of 1~5 part of probiotics, 35~40 DEG C of inoculation
Ferment 5~10 days, after anaerobic fermentation, concentrated broth was stand-by；
Wherein, the weight ratio of content feed liquid and purified water is 1:1~5, anaerobic fermentation is stirred at interval of 6~12h in the process
Content feed liquid is primary；And
The probiotics are at least one of Lactobacillus rhamnosus, cheese lactic acid bacteria and lactobacillus plantarum and Bulgarian bar
The mix bacterium agent of bacterium and bifidobacterium longum composition.
7. the preparation method of the soft capsule of replenishing vitamins AD as claimed in claim 6, which is characterized in that the probiotics
For the mix bacterium agent of Lactobacillus rhamnosus, lactobacillus plantarum, bacillus bulgaricus and bifidobacterium longum composition, the probiotics
It is 2~3 parts；
Wherein, the ratio of number of Lactobacillus rhamnosus, lactobacillus plantarum, bacillus bulgaricus and bifidobacterium longum is 1:1~
5:1:1~5.
8. the preparation method of the soft capsule of replenishing vitamins AD as claimed in claim 7, which is characterized in that the content material
Liquid and the weight ratio of purified water are 1:2, the probiotics are anaerobic fermentation 7 days under the conditions of 3 parts, 38 DEG C；
The fermentation liquid is concentrated into water content lower than 25%.
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| CN111602820A (en) * | 2020-05-28 | 2020-09-01 | 广州富诺营养科技有限公司 | Drop containing vitamin A and vitamin D and its preparation method |
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