CN107213343A - A kind of canker sore Chinese medicine ointment containing bletilla and preparation method thereof - Google Patents
A kind of canker sore Chinese medicine ointment containing bletilla and preparation method thereof Download PDFInfo
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- CN107213343A CN107213343A CN201710426369.2A CN201710426369A CN107213343A CN 107213343 A CN107213343 A CN 107213343A CN 201710426369 A CN201710426369 A CN 201710426369A CN 107213343 A CN107213343 A CN 107213343A
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- bletilla
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of canker sore Chinese medicine ointment containing bletilla, including bletilla, radix ampelopsis, luffa, 50 parts of described bletilla powder, 50 parts of radix ampelopsis powder, 200 parts of luffa concentrated decoction.The preparation method of canker sore Chinese medicine ointment, is comprised the following steps that：(1) making of bletilla powder；(2) radix ampelopsis powder makes；(3) luffa concentrated decoction makes；(4) raw material is mixed；(5) sieve；(6) medicinal powder is mixed；(7) weigh；(8) ointment makes.The beneficial conditions of the present invention are：Manufacture craft is simple, and dose is few, and drug effect is fast, and externally used paste is directly coated at affected part, drug effect go directly affected part, affected part blood concentration height.
Description
Technical field
The present invention relates to a kind of canker sore Chinese medicine ointment containing bletilla treated canker sore, mitigate or even eliminate pain
And preparation method thereof.
Background technology
Canker sore, also known as aphtha, are the superficial ulcers occurred on oral mucosa, big I is from the grain of rice to soya bean
Size, into circular or oval, ulcer surface for it is recessed, around it is congested, pain, one or two general star can be triggered because of irritable food
Phase can be with self-healing.Canker sore inducement is probably local trauma, stress, food, medicine, hormonal readiness change and vitamin
Or microelement deficiencies.Systemic disease, heredity, immune and microorganism may play Chinese medicine in the generation, development of canker sore
Effect.
Canker sore ointment or medicinal powder are the Chinese medicine means for treating canker sore, contrast prior art：(plum flood is a kind of
Treat the Chinese medicine ointment of canker sore：China, CN201510011114.0 [P] .2015-4-8.) to write in patent, its feature exists
In：Smearing ointment is made by the herbal raw material of following part by weight：It is radix scutellariae 10g, cape jasmine 8g, leaf of bamboo 10g, akebi 5g, profound bright
Powder 10g, honeysuckle 8g, qingdai powder 8g, asarum 5g, gypsum 10g, wrinkled giant hyssop 5g, windproof 7g, calamus 10g, ginger 6g, lotus root starch 7g,
Dried orange peel 5g, Semen Coicis 8g, Chinese rose 5g, Chinese cassia tree 5g, bighead atractylodes rhizome 8g, monkshood 7g, Divine Comedy 5g, root of kudzu vine 5g, dried rhizome of rehmannia 10g, Radix Angelicae Sinensis 10g, the bletilla striata
8g, honey 15, vitamin B2 piece 2, above Chinese medicine is crushed, grind, sieved, is soaked 5 hours in clear water, big fire is boiled,
Slow fire is boiled 30 minutes, is removed slag and is stayed liquid, loads aluminium box with holes, high pressure steam sterilization 30 minutes.Add and ground to form after cooling
The vitamin B2 of powdery, paste is reconciled into honey.(Yang Xiuli, Xue Changsong, the red plum compound stomatocase-treatings cream treatment oral cavity of model
Observation of curative effect [J] traditional Chinese medicine information of mucosal ulcer, 2002, (04)：48.) studied for the preparation process of ointment for ulcerative stomatitis,
Take rhizoma zingiberis, asarum first to extract volatile oil, then add radix scutellariae, the coptis, golden cypress and corydalis tuber traditional extraction 1 time, add while hot
The contracting methylcellulose sodium solution of sterilization, plus qs glycerin, nipalgin and the volatile oil extracted, stir evenly rear sterile working bottling i.e.
Into.Both the above ointment and therapeutic modality have the shortcomings that complex process, dose species be various, drug effect is slow.
《Chicken peak Prescriptions for Universal Relief》Record：" radix ampelopsis, bletilla, half and half liang of trachelospermum jasminoide, take dry person.It is dry to spread in sore for smalls." often external application
Treatment sore is not held back after bursting.Bletilla canker sore Chinese medicine ointment is to change trachelospermum jasminoide on the basis of radix ampelopsis dissipates for luffa concentrated decoction.
Bletilla (Rhizoma Bletillae) derives from the dry tuber of orchid bletilla, bitter, sweet, puckery, be slightly cold, return lung, stomach, liver
Through.《This warp》Calling it, " main Carbuncle swells dislikes sore loses perverse trend in subcutaneous ulcer, the dead flesh of impairment of yin, stomach, and harmful wind, ghost is hit, and miliaria is slow not to be received.”《Compendium of Materia Medica》
Calling it " can enter lung hemostasis, myogenic controls sore." 2010 years versions《Pharmacopoeia of People's Republic of China》Its function is recorded for astringing to arrest bleeding, is disappeared
Swollen myogenic, external application can arresting bleeding and treating cutaneous pyogenic infection.Radix ampelopsis (Ampelopsis Radix) derives from the dry tuber of vitaceae radix ampelopsis,
It is bitter, pungent, be slightly cold, the thoughts of returning home, stomach.First recorded in《This warp》：Main carbuncle swells subcutaneous ulcer sore, dissipating bind gas, analgesic.Version in 2010《The Chinese people are total to
With state's pharmacopeia》Its function is recorded for clearing heat and detoxicating, eliminating stagnation to stop pain, myogenic sore.Luffa (Luffa cylindrica (L.)
Roem.) for Curcurbitaceae sponge gourd ripening fruits fibre bundle.It is sweet, flat, return lung, stomach, Liver Channel.First recorded in《Book on Chinese herbal medicine is new again》：It is " logical
Channels and collaterals, and blood vessels, resolving sputum are pleasant." modern study show luffa concentrated decoction have calmness, analgesia, antiinflammatory action.Luffa leads to
Channel and collaterals analgesic, and and bletilla, radix ampelopsis enters blood vessels fall fire anti-inflammatory.
The content of the invention
To solve the above problems, it is an object of the invention to provide a kind of manufacture craft is simple, dose is few, drug effect is fast, adhesion
In the canker sore Chinese medicine ointment containing bletilla on canker sore surface and preparation method thereof,
To achieve the above object, technical scheme：
A kind of canker sore Chinese medicine ointment containing bletilla, including bletilla, radix ampelopsis, luffa, 50 parts of described bletilla powder, in vain
50 parts of liana powder, 200 parts of luffa concentrated decoction.
Preferably, the main chemical compositions of described bletilla are bibenzyl, luxuriant and rich with fragrance class and its derivative, also containing waving on a small quantity
Hair oil, lymphatic temperament, bletilla mannan and starch (30.5%) and glucose (1.5%).
Preferably, the main chemical compositions of described radix ampelopsis are Polyphenols, active ingredient also have organic acid, triterpene,
Sterol and its glycoside and Anthraquinones.
Preferably, described luffa main chemical compositions are xylan and cellulose, also containing mannosan, gala
Glycan and lignin, polysaccharide, sponge gourd saponin(e, flavones and phenols, protein and amino acids, grease and inorganic elements and organic acid
Class.
The preparation method of canker sore Chinese medicine ointment, is comprised the following steps that：
(1) making of bletilla powder：About 1 hour or so during bletilla stem tuber is soaked, soil is cleaned, fibrous root is removed, through boiling
To inner face without the white heart when take out, shine or a heatable brick bed to surface it is stiff not bond when, hit it is residual must, make any surface finish, weed out impurity, polish
To superfine powder；
(2) radix ampelopsis powder makes：The radix ampelopsis block dried is polishing to superfine powder；
(3) luffa concentrated decoction makes：500g luffa medicinal materials are taken, suitably shreds or crushes, put and suitably decoct container
In, plus ten times of amount pure water submergences, after soaking 20-40 minutes, boiling is heated to, certain time is leached, fried liquid is separated, the dregs of a decoction are in accordance with the law
It is fried 2-3 times, each fried liquid is collected, centrifuges or settles after filtration, low temperature concentrates the dregs of a decoction to concentration 1.5g/ml concentrated decoctions；
(4) raw material is mixed；
(5) sieve：Bletilla powder and radix ampelopsis powder were used into 80 mesh sieves；
(6) medicinal powder is mixed：10~15min will be mixed using high-speed mixer again after the tentatively mixing of bletilla powder and radix ampelopsis powder,
Obtain raw material medicinal powder mixture；
(7) weigh：Take 10g raw material medicinal powder mixtures, 20ml luffa concentrated decoctions；
(8) ointment makes：10g raw materials medicinal powder mixture is mixed with 20ml luffas concentrated decoction 1: 2, loads aluminium with holes
Box, the canker sore Chinese medicine ointment that high pressure steam sterilization is made containing bletilla for 30 minutes.
The beneficial conditions of the present invention are：Manufacture craft is simple, and dose is few, and drug effect is fast, and externally used paste is directly coated at trouble
Place, makes drug effect go directly affected part, affected part blood concentration height.
Embodiment
A kind of canker sore Chinese medicine ointment containing bletilla, including bletilla, radix ampelopsis, luffa, 50 parts of described bletilla powder, in vain
50 parts of liana powder, 200 parts of luffa concentrated decoction.The main chemical compositions of described bletilla are bibenzyl, luxuriant and rich with fragrance class and its derivative, are gone back
Contain a small amount of volatile oil, lymphatic temperament, bletilla mannan and starch (30.5%) and glucose (1.5%).Described radix ampelopsis
Main chemical compositions be Polyphenols, active ingredient also has organic acid, triterpene, sterol and its glycoside and Anthraquinones.Described
Luffa main chemical compositions are xylan and cellulose, also containing mannosan, galactan and lignin, polysaccharide, sponge gourd
Saponin(e, flavones and phenols, protein and amino acids, grease and inorganic elements and organic acid.
The preparation method of canker sore Chinese medicine ointment containing bletilla, is comprised the following steps that：
(1) making of bletilla powder：About 1 hour or so during bletilla stem tuber is soaked, soil is cleaned, fibrous root is removed, through boiling
To inner face without the white heart when take out, shine or a heatable brick bed to surface it is stiff not bond when, hit it is residual must, make any surface finish, weed out impurity, polish
To superfine powder；
(2) radix ampelopsis powder makes：The radix ampelopsis block dried is polishing to superfine powder；
(3) luffa concentrated decoction makes：500g luffa medicinal materials are taken, suitably shreds or crushes, put and suitably decoct container
In, plus ten times of amount pure water submergences, after soaking 20-40 minutes, boiling is heated to, certain time is leached, fried liquid is separated, the dregs of a decoction are in accordance with the law
It is fried 2-3 times, each fried liquid is collected, centrifuges or settles after filtration, low temperature concentrates the dregs of a decoction to concentration 1.5g/ml concentrated decoctions；
(4) raw material is mixed；
(5) sieve：Bletilla powder and radix ampelopsis powder were used into 80 mesh sieves；
(6) medicinal powder is mixed：10~15min will be mixed using high-speed mixer again after the tentatively mixing of bletilla powder and radix ampelopsis powder,
Obtain raw material medicinal powder mixture；
(7) weigh：Take 10g raw material medicinal powder mixtures, 20ml luffa concentrated decoctions；
(8) ointment makes：By 10g raw materials medicinal powder mixture and 20ml luffas concentrated decoction 1：2 mixing, load aluminium with holes
Box, the canker sore Chinese medicine ointment that high pressure steam sterilization is made containing bletilla for 30 minutes.
Said preparation is externally used paste, is directly coated at affected part, drug effect is gone directly affected part, and affected part blood concentration is high, with other
Formulation is compared, and dosage is relatively fewer, solves the difficult problem of clinical large area oral mucosa ulcer medicine-feeding.It is applied to trouble simultaneously
The paste at place affected part is served with external environment in itself isolate, physical protection effect, with reduce friction, prevent secondary sense
The benefits such as dye.
Because this preparation is externally used paste, patient voluntarily can smear at any time, with easy to carry, the characteristics of convenient drug administration,
Also allow for patient's receiving.
Party's composition is conventional Chinese medicine, and Clinical practice has no toxic side effect, and security is good and cheap, Huan Zheyi
In receiving, it is easy to promote, there is good clinical value.
Bletilla glucomannan has promoting blood circulation and hemostasis effect, and the bletilla striata is to the antifungal declines containing methoxyl group, and to hydroxyl
The antibacterial activity enhancing of benzyl compound, the protective effect to organization healing, bletilla striata terpenoid is to people's navel endothelial cell apoptosis
With the effect of cytoskeleton, bletilla polysaccharide has promotion hemopoietic function of bone marrow, and bletilla striata powder has good curative effect to peptic gastric ulcer,
Bletilla polysaccharide, which has, to be promoted the intestinal mucosa reparation of ulcerative colitis, suppresses body inflammatory and recover the effect of immunologic balance, tool
There are suppression streptococcus mutans production acid and adhesion.
Antibacterial is the primary pharmacological activity of radix ampelopsis, also with antitumor, immunosupress, hair growth inhibition, and excitement etc. is made
With.
Luffa has inducing diuresis to remove edema, gout of dispelling, and reducing blood lipid is hypoglycemic, anti-oxidant, the effect such as prevention myocardial ischemia, its
Dense decoct has anti-inflammatory, analgesic activity.
It should be understood by those skilled in the art that, the present invention is not limited to the above embodiments, above-described embodiment and explanation
Merely illustrating the principles of the invention described in book, without departing from the spirit and scope of the present invention, the present invention also have
Various changes and modifications, these changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention
By appended claims and its equivalent thereof.
Claims (5)
1. a kind of canker sore Chinese medicine ointment containing bletilla, including bletilla, radix ampelopsis, luffa, it is characterised in that described bletilla
50 parts of powder, 50 parts of radix ampelopsis powder, 200 parts of luffa concentrated decoction.
2. the canker sore Chinese medicine ointment according to claim 1 containing bletilla, it is characterised in that described bletilla it is main
Chemical composition is bibenzyl, luxuriant and rich with fragrance class and its derivative, also containing a small amount of volatile oil, lymphatic temperament, bletilla mannan and starch
(30.5%) with glucose (1.5%).
3. the canker sore Chinese medicine ointment according to claim 1 containing bletilla, it is characterised in that described radix ampelopsis it is main
Chemical composition is Polyphenols, and active ingredient also has organic acid, triterpene, sterol and its glycoside and Anthraquinones.
4. the canker sore Chinese medicine ointment according to claim 1 containing bletilla, it is characterised in that described luffa is main
Chemical composition be xylan and cellulose, also containing mannosan, galactan and lignin, polysaccharide, sponge gourd saponin(e, flavones and
Phenols, protein and amino acids, grease and inorganic elements and organic acid.
5. the preparation method of the canker sore Chinese medicine ointment containing bletilla described in any one in claim 1-4, specific steps are such as
Under：
(1) making of bletilla powder：Will bletilla stem tuber soak in about 1 hour or so, clean soil, remove fibrous root, through boiling to interior
Taken out when face is without the white heart, when solarization or a heatable brick bed are not bonded to surface is stiff, hit residual palpus, make any surface finish, weed out impurity, polishing is extremely
Fine powder；
(2) radix ampelopsis powder makes：The radix ampelopsis block dried is polishing to superfine powder；
(3) luffa concentrated decoction makes：500g luffa medicinal materials are taken, suitably shreds or crushes, puts and suitably decocts in container, plus
Ten times of amount pure water submergences, after soaking 20-40 minutes, are heated to boiling, leach certain time, separate fried liquid, the dregs of a decoction are in accordance with the law fried
2-3 times, each fried liquid is collected, centrifuges or settles after filtration, low temperature concentrates the dregs of a decoction to concentration 1.5g/ml concentrated decoctions；
(4) raw material is mixed；
(5) sieve：Bletilla powder and radix ampelopsis powder were used into 80 mesh sieves；
(6) medicinal powder is mixed：10~15min will be mixed using high-speed mixer again after the tentatively mixing of bletilla powder and radix ampelopsis powder, obtain former
Expect medicinal powder mixture；
(7) weigh：Take 10g raw material medicinal powder mixtures, 20ml luffa concentrated decoctions；
(8) ointment makes：10g raw materials medicinal powder mixture is mixed with 20ml luffas concentrated decoction 1: 2, loads aluminium box with holes,
The canker sore Chinese medicine ointment that high pressure steam sterilization is made containing bletilla for 30 minutes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403970A (en) * | 2018-05-02 | 2018-08-17 | 福建省农业科学院农业工程技术研究所 | A kind of prebiotic compositions and its preparation method and application |
Citations (3)
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|---|---|---|---|---|
| CN104825835A (en) * | 2015-04-25 | 2015-08-12 | 哈药集团中药二厂 | Preparation method of dendrobium nobile oral ulcer buccal tablet |
| EP2954902A1 (en) * | 2014-06-13 | 2015-12-16 | Laurent Haddad | Composition comprising grapefruit seed extract, alchemilla leaf extract, stevia extract and curcumin |
| CN106491857A (en) * | 2016-11-29 | 2017-03-15 | 广西大学 | A kind of treat Chinese medicine preparation of oral ulcer and preparation method thereof |
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2017
- 2017-05-31 CN CN201710426369.2A patent/CN107213343A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2954902A1 (en) * | 2014-06-13 | 2015-12-16 | Laurent Haddad | Composition comprising grapefruit seed extract, alchemilla leaf extract, stevia extract and curcumin |
| CN104825835A (en) * | 2015-04-25 | 2015-08-12 | 哈药集团中药二厂 | Preparation method of dendrobium nobile oral ulcer buccal tablet |
| CN106491857A (en) * | 2016-11-29 | 2017-03-15 | 广西大学 | A kind of treat Chinese medicine preparation of oral ulcer and preparation method thereof |
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| 黄丽萍等: "《美容中药方剂学》", 28 February 2013, 西安交通大学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403970A (en) * | 2018-05-02 | 2018-08-17 | 福建省农业科学院农业工程技术研究所 | A kind of prebiotic compositions and its preparation method and application |
| CN108403970B (en) * | 2018-05-02 | 2020-10-16 | 福建省农业科学院农业工程技术研究所 | Prebiotic composition and preparation method and application thereof |
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