CN110339127A - A kind of cosmetics and its composition, preparation method and the purposes for improving skin function - Google Patents
A kind of cosmetics and its composition, preparation method and the purposes for improving skin function Download PDFInfo
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Abstract
The present invention discloses a kind of cosmetics and its improves composition, preparation method and the purposes of skin function, and composition includes the raw material of following parts by weight: 1-10 parts of fructus lycii, 1-10 parts of purslane, 1-10 parts of Radix Glycyrrhizae.The preparation method of composition is the following steps are included: (1) weighs each raw material by formula rate, and conventional to crush, the water of 5-15 times of raw material weight of addition, 80-100 DEG C is extracted 2-3 times, each time 0.5-2.5 hours；(2) it filters and is centrifuged after merging the extracting solution of step (1), obtain supernatant；(3) supernatant in step (2) is concentrated, obtains concentrate.Also disclose purposes of the composition on preparation antiallergy skin-lightening cosmetic.The present invention is combined with Traditional Chinese medical theory and modern medicine study, and rationally, the raw material of composition is securely and reliably, cheap and easy to get for prescription design.Composition has preferable antiallergy, whitening and anti-aging and other effects, can be used as cosmetic material.
Description
Technical field
The present invention relates to cosmetic field technology, refer in particular to a kind of cosmetics and its improve skin function composition,
Preparation method and purposes.
Background technique
In recent years, with the variation of dietary structure, atmosphere pollution, the increase of life and work pressure, autopath is sharply
Increase, skin sensitivity has become the social concern for influencing human health, and the crowd that the whole world feels sensibility skin gets over
Come more.Have effects that the cosmetics of antiallergy are increasingly subject to the attention of people, the substance with antiallergic activity is especially planted
Favor of the object source material by scholar and market.
" skin whitening " is the eternal topic and pursuit of the vast women that likes to be beautiful.Research and development, safety and the function of Skin whitening care cosmetics
Effect property evaluation nature becomes researcher, operator and consumer's focus of attention.Natural products both safety with higher
Property, and have certain physiological activity, meet consumer demand.Natural products, which is found, as whitening agent becomes cosmetic industry
A development trend.
Summary of the invention
In view of this, in view of the deficiencies of the prior art, the present invention aims to provide a kind of cosmetics and its
Improve composition, preparation method and the purposes of skin function,
To achieve the above object, the present invention is using following technical solution:
A kind of composition improving skin function, the raw material including following parts by weight: 1-10 parts of fructus lycii, purslane 1-10
Part, 1-10 parts of Radix Glycyrrhizae.
It preferably, further include the raw material of following parts by weight: 1-5 parts of radix ampelopsis, 1-5 parts of mulberry root skin, 1-5 parts of radix cynanchi atrati and Rhizoma Atractylodis Macrocephalae 1-
One of 5 parts or a variety of.
Preferably, it is made of the raw material of following parts by weight: 1-10 parts of fructus lycii, 1-10 parts of purslane, 1-10 parts of Radix Glycyrrhizae,
And one of 1-5 parts of radix ampelopsis, 1-5 parts of mulberry root skin, 1-5 parts of radix cynanchi atrati and 1-5 parts of Rhizoma Atractylodis Macrocephalae or a variety of.
Preferably, be made of the raw material of following parts by weight: 6 parts of fructus lycii, 6 parts of purslane, 2 parts of Radix Glycyrrhizae, 2 parts of radix ampelopsis,
2 parts of mulberry root skin, 1 part of radix cynanchi atrati and 1 part of Rhizoma Atractylodis Macrocephalae；1 part of fructus lycii, 9 parts of purslane, 2 parts of Radix Glycyrrhizae, 2 parts of radix ampelopsis and 5 parts of Rhizoma Atractylodis Macrocephalae；Or Chinese holly
1 part of matrimony vine, 1 part of purslane, 1 part of Radix Glycyrrhizae, 5 parts of radix ampelopsis, 5 parts of mulberry root skin and 5 parts of radix cynanchi atrati.
A kind of cosmetics, the cosmetics include the aforementioned composition for improving skin function.
Preferably, cosmetics further include acceptable reagent or carrier on cosmeceutical；Preferably, composition is in describedization
Weight percent in cosmetic is 5-30%；It is highly preferred that weight percent of the composition in the cosmetics is 10%.
A kind of preparation method for the composition improving skin function, comprising the following steps:
(1) each raw material is weighed by formula rate, it is conventional to crush, the water of 5-15 times of raw material weight is added, 80-100 DEG C mentions
It takes 2-3 times, each time 0.5-2.5 hours；
(2) it filters and is centrifuged after merging the extracting solution of step (1), obtain supernatant, the filtering is with 50-80 mesh
Filtering, the centrifugation are 8000-15000 revs/min；
(3) supernatant in step (2) is concentrated, obtains concentrate；Preferably, step (2) is described is filtered into 60 meshes
Filtering, the centrifugation are 12000 revs/min.
Preferably, the supernatant of the step (2) further uses ceramic membrane separation method to be refiltered, and obtains filtered solution,
And/or concentration described in the step (3) is decompression, thin film evaporation or is concentrated using reverse osmosis (RO) membrane separation process.
Preferably, further comprise following steps (4): by the concentrate of step (3), spray drying obtains solid powder
End.
A kind of purposes for the composition improving skin function, is used to prepare in antiallergy and the fair-complexioned cosmetics of U.S..
The present invention has obvious advantages and beneficial effects compared with the existing technology, specifically, by above-mentioned technical proposal
Known to:
(1) present invention is combined with Traditional Chinese medical theory and modern medicine study, and prescription design is reasonable, the original of composition
Material, it is securely and reliably, cheap and easy to get.
(2) present invention has preferable antiallergy, whitening and anti-aging and other effects, can be used as cosmetic material.
(3) preparation method of the present composition is combined with traditional handicraft and modern advanced isolation technics, embodies biography
The characteristic of side under unified central planning greatly remains the various active materials in raw material.
Specific embodiment
Present invention discloses a kind of composition for improving skin function, the raw materials including following parts by weight: fructus lycii 1-10
Part, 1-10 parts of purslane, 1-10 parts of Radix Glycyrrhizae.It further include the raw material of following parts by weight: 1-5 parts of radix ampelopsis, 1-5 parts of mulberry root skin, radix cynanchi atrati
1-5 parts and one of Rhizoma Atractylodis Macrocephalae 1-5 parts or a variety of.
In above-mentioned composition, the source of each raw material, nature and flavor, channel tropism, effect and related research are described as follows:
Fructus lycii: for the dry mature fruit of Lycium barbarum L. of solanaceae Lycium barbarum L..It is sweet in flavor, it is mild-natured.
Return liver and kidney channel.Effect is nourishing liver and kidney, benefiting shrewd head.Shennong's Herbal is classified as top grade, records: " perverse trend, hankers disappearing in main five
Yearningly；General arthralgia, long term usage heavily fortified point muscles and bones are made light of one's life by commiting suicide not old." Compendium of Material Medica record: " vital essence various symptims and signs of deficiency is mended, Yi Yanse bleaches, improving eyesight peace
Mind makes us long-lived." studies have shown that amino acid, inorganic salts, microelement and vitamin rich in fructus lycii, fructus lycii are extracted
Liquid is remarkably improved the activity of SOD in mouse skin, increases collagen content in skin, reduces lipid peroxidation product the third two
The content of aldehyde, has the function of delay skin aging.Fructus lycii water extract solution is added in face cream, efficacy test result table
It is bright addition fructus lycii water extract solution face cream have the function of moisturizing, whitening and enhancing skin elasticity, and safely, to skin without
Irritation [Liu Chang, Mo Siying, Gong Shengzhao.Application study of the fructus lycii water extract in cosmetic cream.Daily chemical industry,
2013,43 (3): 213-216].
Purslane: for the dry aerial parts of Purslane plants purslane Portulaca oleracea L..It is sour, property
It is cold.Return liver, large intestine channel.Effect is clearing heat and detoxicating, cooling blood and hemostasis.Shennong's Herbal is recorded: "." Compendium of Material Medica record: " dissipate blood
Detumescence, sharp intestines habitual abortion, detoxify treating stranguria, abnormal sweating after managing property." using purslane as research object, antibacterial to its by a variety of methods,
Whitening and anti-aging, anti-inflammatory, antiallergic and other effects study and evaluate its safety.The results show that purslane have compared with
Good antibacterial, whitening and anti-aging, anti-inflammatory, antiallergic effect is a kind of safe and non-stimulating cosmetic material [Liu Xiaomin, Long Chun
Rosy clouds.The more efficacy studies and safety evaluatio of purslane.Daily chemical industry, 2018,48 (2): 88-93].
Radix Glycyrrhizae: for glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza
The dry root and rhizome of inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..It is sweet in flavor, it is mild-natured.Return heart, lung,
Spleen, stomach meridian.Effect is invigorated the spleen and benefited qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.Shennong's Herbal is classified as
Product are recorded: " main six mansion fever and chills perverse trend of the five internal organs；Hard muscles and bones, long muscle, times power；Metal-inflicted wound is swollen；Removing toxic substances.Long term usage is made light of one's life by commiting suicide macrobiosis." " this
Careless detailed outline " it records: " solution infant fetal toxin frightened epilepsy, fall fire analgesic." in cosmetic field, Radix Glycyrrhizae has the title of " whitening queen ".
It has been found that the type of compounds with generic chemical structure has triterpenoid saponin (4%-24%, mainly glycyrrhizic acid), Radix Glycyrrhizae in Radix Glycyrrhizae
General flavone (1%-5%), alkaloid, polysaccharide, amino acid (1%-2%) etc..Effective component in Radix Glycyrrhizae have antioxygen, antiallergy,
Anti-inflammatory, anti-skin neoplasin and effectively dispel the effect of skin splash, also have prevent skin aging, effectively remove superoxide ion and
The effects of inhibiting the activity of tyrosinase.In cosmetics, it can be configured to face cream, content in freckle cream, superior pearls frost etc., played anti-
Shine, brighten, anti-inflammatory and treatment skin disease the effects of [Zhao Yaxin, Gao Wenyuan, Zhang Lianxue, etc..Application of the Radix Glycyrrhizae in cosmetics.
Fragrance flavor and cosmetic, 2010, (4): 146-156].
Radix ampelopsis: for the dried root of vitaceae radix ampelopsis Ampelopsis japonica (Thunb.) makino.Taste
Hardship, cold nature.Return heart, stomach meridian.Effect is clearing heat and detoxicating, carbuncle that disappears dissipating bind, expelling pus and promoting granulation.Shennong's Herbal is classified as low-grades, records:
" control carbuncle swells, subcutaneous ulcer, sore, dissipating bind gas, analgesic, except heat, red, pediatric epilepsy scared in mesh, a kind of malaria swells and ache in woman's yin, and leukorrhagia is red white."
Compendium of Material Medica is recorded: " solution radix euphorbiae lantu." radix ampelopsis as traditional Chinese medicine simply, the successively isolated flavonoids of domestic and foreign scholars,
A variety of chemical components such as sterols, Anthraquinones, phenolic acid class and its glucosides, triterpenes, lignanoids.With antibacterial, antitumor, tune
The effects of saving immunocompetence, expelling pus and promoting granulation promotion ulcer surface healing [Chen Aijun, Liu Yunmei, Cai Fengtao, etc..Radix ampelopsis progress.
China National folk medicine, 2014, (13): 10-11].
Mulberry root skin (root bark of white mulberry): for the dry root skin of moraceae plants mulberry Morus alba L..It is sweet in flavor, it is cold in nature.It is distributed in lung channel.
Effect removing heat from lung and relieving asthma, inducing diuresis for removing edema.Shennong's Herbal is classified as middle product, and record: " in curing the wound, exhaustion or lesion of the five internal organs sextupole is thin thin, metrorrhagia, arteries and veins
Absolutely, tonify deficiency benefit health." Compendium of Material Medica record: " purging the lung of pathogenic fire, sharp intestine and small intestine, sending down abnormally ascending dissipate blood." mulberry root skin mainly contains flavonoid
Object, Coumarins and polysaccharide etc..Root bark of white mulberry water extract has the good activity for inhibiting tyrosinase, and safety is big
Crowd approves, develops skin-lightening cosmetic with it and has good market prospects.This 3 kinds of mulberry skin glucoside, resveratrol, oxidized resveratrol
Mulberry tree talan substance has been applied in Skin whitening care cosmetics [Wu Yanan, Huang Zenghui, Xu Li in South Korea.Mulberry tree whitening is living
The progress of property.Bombycology communication, 2013,33 (2): 7-14].
Radix cynanchi atrati: for Asclepiadaceae plant radix cynanchi atrati Cynanchum atratum Bge. or Cynanchum versicolor Bunge Cynanchum
The dry root and rhizome of versicolor Bge..It is bitter, salty, it is cold in nature.Return stomach, liver and kidney channel.Effect clearing heat and cooling blood, diuresis are logical
Leaching, detoxification sore treatment.Shennong's Herbal is classified as middle product, records: " sudden and violent apoplexy, the hot limb of body are full, before we notice it does not know people, mad puzzled perverse trend is trembled with fear
Hot acid pain, a kind of malaria are washed, disease appearing at regular intervals,disease breaking out at interval time." Compendium of Material Medica record: " the scorching hot more dormancies of wind-warm syndrome and the heat gonorrhea enuresis, metal-inflicted wound bleeding."
The inhibitory effect that the percutaneous permeate of Primary Study radix cynanchi atrati is proliferated B16 melanoma cells, radix cynanchi atrati have certain whitening function,
Can be used for whitening product exploitation [Chen Xiaolu, Bi Yingna, Liu Chengping, etc..The percutaneous permeate of radix cynanchi atrati is to B16 melanoma cells
Effect.Chinese experimental pharmacology of traditional Chinese medical formulae magazine, 2014,20 (12): 193-196].
Rhizoma Atractylodis Macrocephalae: for the dry rhizome of compositae plant Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Bitter,
It is sweet, it is warm-natured.Returns spleen, stomach meridian.Effect strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis.Shennong's Herbal is classified as top grade, records: " chill
Arthritis with fixed pain caused by dampness, dead flesh convulsion subcutaneous ulcer, hidroschesis help digestion except heat, make to decoct bait long term usage, macrobiosis of making light of one's life by commiting suicide is not hungry." " haigoushen " record, " Rhizoma Atractylodis Macrocephalae has interarea
Light pleases, preserves youthful looks, de-black and other effects "；The Tang Dynasty " Tang materia medica " claim, Rhizoma Atractylodis Macrocephalae with " Bitters soaks it, with the face of wiping it is black it is dry dismiss, pole imitate "." doctor
Learn introduction " record, Rhizoma Atractylodis Macrocephalae can with invigorating qi and benefiting blood, whitening and moistening skin, be suitable for the qi and blood cold of insufficiency type caused by pachylosis, sallow, chloasma,
Pigmentation etc..The beauty functions of Rhizoma Atractylodis Macrocephalae are related with the main chemical compositions that it contains, and main component is atractylol, atractylone
And vitamin A, volatile oil etc..Have tonifying spleen, beneficial stomach, eliminating dampness function.It because spleen is source of generating QI and blood, and is the ground of water-wet transporting.
Then sallow complexion is not magnificent for insufficiency of generating and transforming QI and blood；Retention of water-damp is then stopped at face in aqueous vapor, then the black no pool in face, therefore commonly uses in beauty side
Rhizoma Atractylodis Macrocephalae is to control its [Wang Ruina, Tang Qian, He Fengfa.The pharmacological action of medicinal Rhizoma Atractylodis Macrocephalae and its comprehensive development and utilization.Agriculture of Anhui section
It learns, 2010,38 (11): 5610-5611].
The invention also discloses a kind of cosmetics, the cosmetics include the aforementioned composition for improving skin function.Makeup
Product further include acceptable reagent or carrier on cosmeceutical；Preferably, weight percent of the composition in the cosmetics
For 5-30%；It is highly preferred that weight percent of the composition in the cosmetics is 10%.
Composition of the invention may be at convenient for save liquid condition or solid state, can according in this field
The method known is added in cosmetics, prepare corresponding condensation, cream, lotion, foundation cream, toner, facial mask, detergent or other
Known cosmetics.
Acceptable beneficial agent or carrier on cosmeceutical, including but not limited to whitening agent, moisturizer, thickener, cream
Agent, antioxidant, preservative, essential oil etc., wherein whitening agent includes but is not limited to niacinamide, arbutin, glabridin etc.；It protects
Humectant includes but is not limited to glycerol, propylene glycol, hexylene glycol, D-pantothenyl aleohol, Sodium Hyaluronate, hyaluronic acid, allantoin etc.；Thickener
Including but not limited to xanthan gum, carbomer, polyvinylpyrrolidone, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, PVM/MA
Decadiene crosslinked polymer etc.；Emulsifier includes but is not limited to the esters of D-sorbite, esters of anhydrosorbitol acid anhydride etc.；It is anti-
Oxidant includes but is not limited to ascorbic acid and its derivative, tocopherol and its derivative etc.；Preservative includes but is not limited to benzene
Oxyethanol, methylisothiazolinone, bi-imidazolidinyl urea, parabens etc.；Essential oil includes but is not limited to attar of rose, peppermint
Oil, lavender oil, evening primrose oil etc.；Routinely technique is made any kind of cosmetics, including but not limited to condensation, cream,
Lotion, foundation cream, toner, facial mask, detergent or other known cosmetics.
The present invention discloses a kind of preparation method of aforementioned composition for improving skin function again, comprising the following steps:
(1) each raw material is weighed by formula rate, it is conventional to crush, the water of 5-15 times of raw material weight is added, 80-100 DEG C mentions
It takes 2-3 times, each time 0.5-2.5 hours；
(2) it filters and is centrifuged after merging the extracting solution of step (1), obtain supernatant, the filtering is with 50-80 mesh
Filtering, the centrifugation are 8000-15000 revs/min；
(3) supernatant in step (2) is concentrated, obtains concentrate；Preferably, step (2) is described is filtered into 60 meshes
Filtering, the centrifugation are 12000 revs/min.
The supernatant of the step (2) further uses ceramic membrane separation method to be refiltered, and obtains filtered solution and/or institute
Concentration described in step (3) is stated to be concentrated for decompression, thin film evaporation or using reverse osmosis (RO) membrane separation process.
It further comprises following steps (4): by the concentrate of step (3), spray drying obtains solid powder.
The present invention discloses a kind of purposes of composition for improving skin function again, is used to prepare antiallergy and whitening skin
On the cosmetics of color.
With multiple embodiments, invention is further described in detail below:
The preparation of example 1 group conjunction object 1:
1. weighing fructus lycii 9kg, purslane 9kg, Radix Glycyrrhizae 5kg, with beater disintegrating machine, (model WF-B, Nanjing space expect machine
Tool Science and Technology Ltd.) it crushed 5 meshes, it is spare.
2. multifunctional dynamic extraction pot (model 0.5m is added in comminuting matter3, the limited public affairs of Zhangjiagang Tian Bao machine-building
Department), 90 ± 5 DEG C of extractions are secondary.The water of 15 times of material quantities for the first time, the time 1.5 hours；The water of second of 10 times of material quantity, when
Between 1.0 hours, 60 mesh screens, coarse filtration liquid merge, tube centrifuge continuous high speed be centrifuged (10000 revs/min of revolving speed), centrifugation
(- 0.06Mpa~-0.08Mpa, 70 ± 5 DEG C) is concentrated under reduced pressure in supernatant, concentrate Brix value (Japanese ATAGO saccharometer)
52.3%, after pasteurization, sterile bag is poured into, it is spare.Concentrate is diluted with pure water, constant volume is configured to concentration 100mg/L,
That is composition containing 100mg in 1L pure water.
The preparation of 2 composition 2 of embodiment:
1. weighing fructus lycii 9kg, purslane 1kg, Radix Glycyrrhizae 1kg, radix ampelopsis 5kg, it crushed 5 meshes with beater disintegrating machine,
It is spare.
2. multifunctional dynamic extraction pot is added in comminuting matter, 95 ± 5 DEG C of extractions are secondary.10 times of material quantities for the first time
Water, the time 1.0 hours；The water of second of 5 times of material quantity, the time 0.5 hour；60 mesh screens, coarse filtration liquid merge, tubular type centrifugation
Machine continuous high speed is centrifuged (10000 revs/min of revolving speed), and centrifuged supernatant reduced pressure (- 0.06Mpa~-0.08Mpa, 70 ± 5
DEG C), concentrate Brix value 52.7% pours into sterile bag after pasteurization, spare.Concentrate is diluted with pure water, constant volume is matched
Concentration 100mg/L, i.e. composition containing 100mg in 1L pure water is made.
The preparation of 3 composition 3 of embodiment:
1. fructus lycii 6kg, purslane 6kg, Radix Glycyrrhizae 2kg, mulberry root skin 2kg, radix ampelopsis 2kg, radix cynanchi atrati 1kg, Rhizoma Atractylodis Macrocephalae 1kg are weighed,
It crushed 5 meshes with beater disintegrating machine, it is spare.
2. multifunctional dynamic extraction pot is added in comminuting matter, 90 ± 5 DEG C of extractions are secondary.12 times of material quantities for the first time
Water, the time 1.0 hours；The water of second of 8 times of material quantity, the time 0.5 hour；60 mesh screens, coarse filtration liquid merge, and tubular type is continuous
High speed centrifugation (14000 revs/min of revolving speed), centrifuged supernatant with ceramic membrane (0.2 μm of membrane aperture, through flow velocity 60L/hr) into
Row micro-filtration collects trapped fluid, and using reverse osmosis membrane, (molecular cut off 100 is concentrated trapped fluid through flow velocity 90L/hr), concentration
Liquid Brix value 53.9% pours into sterile bag after pasteurization, spare.Concentrate is diluted with pure water, constant volume is configured to concentration
100mg/L contains 100mg composition that is, in 1L pure water.
The preparation of 4 composition 4 of embodiment:
1. weighing fructus lycii 1kg, purslane 9kg, Radix Glycyrrhizae 2kg, radix ampelopsis 1kg, Rhizoma Atractylodis Macrocephalae 5kg, crushed with beater disintegrating machine
5 meshes are crossed, it is spare.
2. multifunctional dynamic extraction pot is added in comminuting matter, 80 ± 5 DEG C are extracted three times.15 times of material quantities for the first time
Water, the time 1.5 hours；The water of second of 10 times of material quantity, the time 1.0 hours；The water of 5 times of material quantities for the third time, time 0.5 are small
When；60 mesh screens, coarse filtration liquid merge, and tubular type continuous high speed is centrifuged (14000 revs/min of revolving speed), centrifuged supernatant ceramics
(0.2 μm of membrane aperture, carry out micro-filtration through flow velocity 60L/hr) to film, collects trapped fluid, trapped fluid is using reverse osmosis membrane (retention point
Son amount 100, is concentrated, concentrate Brix value 53.5% pours into sterile bag after pasteurization, standby through flow velocity 90L/hr)
With.Concentrate is diluted with pure water, constant volume is configured to concentration 100mg/L, i.e., contains 100mg composition in 1L pure water.
The preparation of 5 composition 5 of embodiment:
1. weighing fructus lycii 1kg, purslane 1kg, Radix Glycyrrhizae 1kg, radix ampelopsis 5kg, mulberry root skin 5kg, radix cynanchi atrati 5kg, hammer slice type is used
Pulverizer crushed 5 meshes, spare.
2. multifunctional dynamic extraction pot is added in comminuting matter, 90 ± 5 DEG C are extracted three times.12 times of material quantities for the first time
Water, the time 1.0 hours；The water of second of 8 times of material quantity, the time 0.5 hour；The water of 6 times of material quantities for the third time, time 0.5 are small
When；60 mesh screens, coarse filtration liquid merge, and tubular type continuous high speed is centrifuged (14000 revs/min of revolving speed), centrifuged supernatant ceramics
(0.2 μm of membrane aperture, carry out micro-filtration through flow velocity 60L/hr) to film, collects trapped fluid, trapped fluid is using reverse osmosis membrane (retention point
Son amount 100, is concentrated, concentrate Brix value 53.1% pours into sterile bag after pasteurization, standby through flow velocity 90L/hr)
With.Concentrate is diluted with pure water, constant volume is configured to concentration 100mg/L, i.e., contains 100mg composition in 1L pure water.
Embodiment 6: the preparation of fructus lycii maintenance essence dew:
1. carbomer is dissolved in part water (65 DEG C), is slowly stirred to being completely dissolved, is cooled in production containers
30℃。
2. by concentrate made from embodiment 3 and glycerol, propylene glycol, niacinamide, hexylene glycol, parahydroxyacet-ophenone, grape
Shaddock oil, Sodium Hyaluronate, hyaluronic acid and allantoin etc. are put into production containers, and vacuum is slowly stirred to formation at 30 DEG C
Supernatant liquid is cooled to room temperature, and triethanolamine is added and adjusts pH, remaining water is added, and is slowly stirred uniformly smooth to being formed
Essence dew.Ingredient and ratio in essence dew formula are shown in Table 1.
Ingredient and ratio in 1 essence of table dew formula
The preparation of 1 composition a of comparative example:
1. weighing fructus lycii 9kg, purslane 9kg, it crushed 5 meshes with beater disintegrating machine, it is spare.
2. multifunctional dynamic extraction pot is added in comminuting matter, 90 ± 5 DEG C of extractions are secondary.15 times of material quantities for the first time
Water, the time 1.5 hours；The water of second 10 times of material quantities, the time 1.0 hours, 60 mesh screens, coarse filtration liquid merged, tubular type from
Scheming continuous high speed is centrifuged (10000 revs/min of revolving speed), centrifuged supernatant reduced pressure (- 0.06Mpa~-0.08Mpa, 70 ±
5 DEG C), concentrate Brix value 152.3% pours into sterile bag after pasteurization, spare.Concentrate, constant volume are diluted with pure water
It is configured to concentration 100mg/L, i.e. composition containing 100mg in 1L pure water.
The preparation of 2 composition b of comparative example:
1. weighing fructus lycii 9kg, Radix Glycyrrhizae 5kg, it crushed 5 meshes with beater disintegrating machine, it is spare.
2. multifunctional dynamic extraction pot is added in comminuting matter, 90 ± 5 DEG C of extractions are secondary, 12 times of material quantities of first time
Water, the time 1.0 hours, the water of second of 8 times of material quantity, the time 0.5 hour, 60 mesh screens, coarse filtration liquid merged, tubular type centrifugation
Machine continuous high speed is centrifuged (10000 revs/min of revolving speed), and centrifuged supernatant reduced pressure (- 0.06Mpa~-0.08Mpa, 70 ± 5
DEG C), concentrate Brix value 52.2% pours into sterile bag after pasteurization, spare.Concentrate is diluted with pure water, constant volume is matched
Concentration 100mg/L, i.e. composition containing 100mg in 1L pure water is made.
The preparation of 3 composition c of comparative example:
1. weighing purslane 9kg, Radix Glycyrrhizae 5kg, it crushed 5 meshes with beater disintegrating machine, it is spare.
2. multifunctional dynamic extraction pot is added in comminuting matter, 90 ± 5 DEG C of extractions are secondary, 12 times of material quantities of first time
Water, the time 1.0 hours, the water of second of 8 times of material quantity, the time 0.5 hour, 60 mesh screens, coarse filtration liquid merged, tubular type centrifugation
Machine continuous high speed is centrifuged (10000 revs/min of revolving speed), and centrifuged supernatant reduced pressure (- 0.06Mpa~-0.08Mpa, 70 ± 5
DEG C), concentrate Brix value 52.5% pours into sterile bag after pasteurization, spare.Concentrate is diluted with pure water, constant volume is matched
Concentration 100mg/L, i.e. composition containing 100mg in 1L pure water is made.
The preparation of 4 composition d of comparative example:
1. weighing fructus lycii 9kg, purslane 9kg, Chinese herbaceous peony 5kg, it crushed 10 meshes with beater disintegrating machine, it is spare.
2. multifunctional dynamic extraction pot is added in comminuting matter, 90 ± 5 DEG C are extracted three times.12 times of material quantities for the first time
Water, the time 1.0 hours；The water of second of 8 times of material quantity, the time 0.5 hour；The water of 6 times of material quantities for the third time, time 0.5 are small
When；60 mesh screens, coarse filtration liquid merge, and tube centrifuge continuous high speed is centrifuged (14000 revs/min of revolving speed), centrifuged supernatant
With ceramic membrane, (0.2 μm of membrane aperture, carry out micro-filtration through flow velocity 60L/hr), collects trapped fluid, and trapped fluid uses reverse osmosis membrane
(molecular cut off 100, is concentrated through flow velocity 90L/hr), and concentrate Brix value 52.6% after pasteurization, pours into nothing
Bacterium bag, it is spare.Concentrate is diluted with pure water, constant volume is configured to concentration 100mg/L, i.e. composition containing 100mg in 1L pure water.
The comparison of the formula of above embodiments and comparative example is shown in Table 2.
Ingredient and ratio shown in each composition of table 2
Effect example 1:
Hyaluronic acid (hyaluronic acid, HA) is that content is most in extracellular matrix (ECM), proportion is maximum
Ingredient, there is very strong water absorbing capacity and adhesiveness, the secretion of controllable cell factor influences the growth of cell, be proliferated, move
Shifting and differentiation, thus it is main maintaining moisture of skin and elasticity, wound healing and vascularization etc. to serve in the process.It is transparent
Matter acid enzyme is the Specific lytic enzymes of hyaluronic acid, inhibits the activity of hyaluronidase i.e. and can guarantee the content and just of hyaluronic acid
Chang Gongneng.Hyaluronidase body outer suppressioning test is most typical antiallergic activity rating in-vitro method, is inhibited with hyaluronidase
Rate is the antiallergic activity of metrics evaluation substance, and the more big then antiallergic activity of hyaluronic acid enzyme inhibition rate is stronger.
Hyaluronidase body outer suppressioning test: 0.1mLCaCl is taken2Solution (0.25mmol/L) and 0.5mL hyaluronidase
37 DEG C of heat insulating culture 20min of liquid (1250u/mL)；Sample liquid 0.5mL is added, continues 37 DEG C of heat insulating culture 20min；0.5mL is added
Sodium Hyaluronate liquid (0.5mg/mL) 37 DEG C of heat preservations 30min, room temperature 5min；It is added 0.1mLNaOH solution (0.4mol/L)
With 0.5mL acetylacetone,2,4-pentanedione solution, it is placed in boiling water bath after heating 15min and carries out cooling 5min with ice water immediately；Ai Erli is added
Uncommon reagent 1.0mL is simultaneously diluted with 3.0mL dehydrated alcohol, 20min colour developing is placed, with spectrophotometer (UV-1750 type, day
This Shimadzu Corporation) measure its absorbance value.
(1) hyaluronic acid enzyme inhibition rate is calculated by formula:
(1) hyaluronic acid enzyme inhibition rate (%)={ (A-B)-(C-D)/A-B } × 100%.
In formula: for A by contrast solution absorbance (replacing sample solution with hac buffer), B is that control blank solution is inhaled
Luminosity (replaces sample solution and enzyme solution with hac buffer), and C is sample solution absorbance value, and D is the suction of sample blank solution
Luminosity (replaces enzyme solution with hac buffer).The wavelength for first carrying out 450-700nm range to A control group sample when test is swept
It retouches, to determine maximum absorption wavelength, then using deionized water as reference, carries out relevant group respectively at the maximum absorption wavelength
Absorbance measurement.
Statistical procedures are carried out using SPSS19.0 software, measurement data indicates that sample room is poor using mean ± standard deviation
Different comparison is examined with t.Test result is shown in Table 3.
3 hyaluronidase body outer suppressioning test result of table
Note: hyaluronic acid enzyme inhibition rate is compared with composition d, P < 0.01 * *.
As shown in the results, the composition a-d of composition 1-5 and comparative example the 1-4 preparation of 1-5 of embodiment of the present invention preparation is equal
It can inhibit hyaluronidase activity, and the composition 1-5 effect that 1-5 of the embodiment of the present invention is obtained is extremely significant.In particular, this
Compared with the composition d (i.e. inhibitory effect is best in comparative example 1-4) that comparative example 4 obtains, difference has inventive composition 1-5
Extremely significant property shows that composition of the invention achieves unexpected technical effect.
Effect example 2:
The color of skin mainly determines that melanin is most important determinant by skin pigment content and distribution.Black
The synthesis of element mainly carries out in melanocyte, and tyrosine is DOPA through tyrosinase catalysis hydroxylation and and then forms DOPA
Quinone, and the effect through DHI oxidizing ferment and DHICA oxidizing ferment generate eumelanin, so tyrosinase is the starting limit of melanogenesis
Fast enzyme.Currently, being the warp of cell in vitro biology screening whitening composition on the active influence of melanin B16 cell tyrosinase
Allusion quotation method.
The measurement of tyrosinase activity in B16 mouse melanin tumor cell: with 5000/hole by the B16 cell (U.S.
ATCC, Shanghai Fu Xiang Biotechnology Co., Ltd) it is inoculated in 96 orifice plates, addition composition or blank control in the orifice plate, 37
DEG C culture 48hr.Every group is done 5 multiple holes.Using levodopa as substrate, in microplate reader (the more function of Varioskan Flash all-wave length
Can microplate reader) place 490nm measurement absorbance.
(1) inhibitory activity against tyrosinase is calculated by formula:
(1) inhibitory activity against tyrosinase=(1-A/B) × 100%.
A is the absorbance of composition group in formula；B is the mean light absorbency of blank control group.
Statistical procedures are carried out using SPSS19.0 software, measurement data indicates that sample room is poor using mean ± standard deviation
Different comparison is examined with t.Test result is shown in Table 4.
The result of table 4B16 intracellular tyrosine enzyme assay
Note: inhibitory activity against tyrosinase is compared with composition d, P < 0.01 * *.
As shown in the results, the composition a-d of composition 1-5 and comparative example the 1-4 preparation of 1-5 of embodiment of the present invention preparation is equal
It can inhibit tyrosinase activity, and the composition 1-5 effect that 1-5 of the embodiment of the present invention is obtained is extremely significant.In particular, this hair
For bright composition 1-5 compared with composition d (inhibitory effect is best in comparative example 1-4), difference has extremely significant property, shows this hair
Bright composition achieves unexpected technical effect.
Effect example 3: composition safety evaluatio-human body patch test:
1. test basis: " cosmetics safety technical specification " (version in 2015)
2. test method and result: selecting subject by subject enrollment standard, number is 30.Select qualified patch
Material is put into spot tester after infiltrating 6 multiple-effect repair hydrosol of embodiment with filter paper, and control wells are that blank control (is not set any
Substance).6 multiple-effect repair hydrosol of embodiment is uniformly added into the small interior of spot tester, it will be added with 6 multiple-effect repair hydrosol of embodiment
Spot tester is pasted on volunteer back with non-stimulated adhesive tape, is gently pressed with palm and is allowed to uniformly be pasted on skin, spot tester is lasting
It stops on the skin for 24 hours.Patch device interval 30min is removed, observes dermoreaction after impression disappearance.After patch test for 24 hours and
48h is observed once respectively.Human body patch test is it is found that participating in 28 people in this time 30 subjects of test is 0 order reaction, 2 people
For 1 order reaction (suspicious reaction, only faint erythema), illustrate that the multiple-effect repair hydrosol of embodiment 6 does not cause not human skin
Good reaction.
The technical principle of the invention is described above in combination with a specific embodiment.These descriptions are intended merely to explain of the invention
Principle, and shall not be construed in any way as a limitation of the scope of protection of the invention.Based on the explanation herein, the technology of this field
Personnel can associate with other specific embodiments of the invention without creative labor, these modes are fallen within
Within protection scope of the present invention.
Claims (10)
1. a kind of composition for improving skin function, it is characterised in that: the raw material including following parts by weight: 1-10 parts of fructus lycii,
1-10 parts of purslane, 1-10 parts of Radix Glycyrrhizae.
2. improving the composition of skin function as described in claim 1, it is characterised in that: further include the original of following parts by weight
Material: one of 1-5 parts of radix ampelopsis, 1-5 parts of mulberry root skin, 1-5 parts of radix cynanchi atrati and 1-5 parts of Rhizoma Atractylodis Macrocephalae are a variety of.
3. as claimed in claim 2 improve skin function composition, it is characterised in that: its by following parts by weight raw material group
At: 1-5 parts of 1-10 parts of fructus lycii, 1-10 parts of purslane, 1-10 parts of Radix Glycyrrhizae and radix ampelopsis, 1-5 parts of mulberry root skin, 1-5 parts of radix cynanchi atrati and
One of 1-5 parts of Rhizoma Atractylodis Macrocephalae or a variety of.
4. as claimed in claim 3 improve skin function composition, it is characterised in that: its by following parts by weight raw material group
At: 6 parts of fructus lycii, 6 parts of purslane, 2 parts of Radix Glycyrrhizae, 2 parts of radix ampelopsis, 2 parts of mulberry root skin, 1 part of radix cynanchi atrati and 1 part of Rhizoma Atractylodis Macrocephalae；1 part of fructus lycii,
9 parts of purslane, 2 parts of Radix Glycyrrhizae, 2 parts of radix ampelopsis and 5 parts of Rhizoma Atractylodis Macrocephalae；Or 1 part of fructus lycii, 1 part of purslane, 1 part of Radix Glycyrrhizae, 5 parts of radix ampelopsis, Sang Gen
5 parts and 5 parts of radix cynanchi atrati of skin.
5. a kind of cosmetics, which is characterized in that the cosmetics include improvement skin function as described in claim 3 or 4
Composition.
6. cosmetics as claimed in claim 5, it is characterised in that: cosmetics further include on cosmeceutical acceptable reagent or
Carrier；Preferably, weight percent of the composition in the cosmetics is 5-30%；It is highly preferred that composition is in describedization
Weight percent in cosmetic is 10%.
7. a kind of preparation method for the composition for improving skin function according to any one of claims 1 to 4, feature exist
In, comprising the following steps:
(1) each raw material is weighed by formula rate, it is conventional to crush, the water of 5-15 times of raw material weight, 80-100 DEG C of extraction 2-3 is added
It is secondary, each time 0.5-2.5 hours；
(2) it filters and is centrifuged after merging the extracting solution of step (1), obtain supernatant, the filtering is with 50-80 mesh mistake
Filter, the centrifugation are 8000-15000 revs/min；
(3) supernatant in step (2) is concentrated, obtains concentrate；Preferably, step (2) is described is filtered into 60 mesh screens,
The centrifugation is 12000 revs/min.
8. improving the preparation method of the composition of skin function as claimed in claim 7, it is characterised in that: the step (2)
Supernatant further use ceramic membrane separation method to be refiltered, obtain dense described in filtered solution and/or the step (3)
It is condensed to decompression, thin film evaporation or is concentrated using reverse osmosis (RO) membrane separation process.
Further comprise following steps (4) 9. improving the preparation method of the composition of skin function as claimed in claim 8:
By the concentrate of step (3), spray drying obtains solid powder.
10. a kind of purposes of the composition of any of claims 1-4 for improving skin function, it is characterised in that: its
It is used to prepare in antiallergy and the fair-complexioned cosmetics of U.S..
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| CN112957304A (en) * | 2021-03-11 | 2021-06-15 | 戴伟 | Plant composition for cosmetics, mixed extracting solution and preparation method |
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