CN104587161A - Traditional Chinese medicine composition for treating nephropathy of amylaidosis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating nephropathy of amylaidosis. The traditional Chinese medicine composition is prepared from 28-32 parts of codonopsis pilosula, 28-32 parts of astragalus membranaceus, 28-32 parts of angelica sinensis, 13-16 parts of ligusticum wallichii, 13-16 parts of leech, 13-16 parts of earthworm, 13-16 parts of peach kernels, 13-16 parts of safflower carthamus, 13-16 parts of herba lycopi, 28-32 parts of leonurus, 13-16 parts of prepared rehmannia root, 13-16 parts of Chinese yam, 13-16 parts of dogwood, 8-12 parts of poria cocos, 13-16 parts of rhizoma alismatis, 8-12 parts of cortex moutan, 28-32 parts of white atractylodes rhizome, 13-16 parts of pinellia ternate, 13-16 parts of tangerine, 18-20 parts of cassia twig, 13-16 parts of thunberg fritillary bulb, 18-20 parts of fructus forsythiae, 28-32 parts of oldenlandia diffusa, 28-32 parts of sophora flower bud, 28-32 parts of wolfberry fruit, 13-16 parts of loranthus parasiticus, 13-16 parts of cordyceps sinensis, 28-32 parts of eucommia ulmoides, 28-32 parts of achyranthes bidentata, 18-20 parts of salvia miltiorrhiza and 8-12 parts of liquorice. The medicine can realize a synchronization therapy of expanding blood vessels, resisting inflammation, resisting coagulation and degrading sediments, thus shortening a therapy period.

Description

A kind of Chinese medicine composition being used for the treatment of features of amyloid nephropathy

Technical field

The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition being used for the treatment of features of amyloid nephropathy.

Background technology

Amyloidosis be due to amyloid filaments with insoluble form at extracellular deposit, cause the systemic disease of multiple organ organizational structure and functional lesion, the nephropathy that wherein amyloid deposition causes in kidney claims features of amyloid nephropathy.Up-to-date medical research is thought, the pathogenic factor of this disease is that some constitutionales or insecondary inflammation cause fibrin deposition in glomerular capillary loop and mesangial region, cause the epithelial immune-mediated damage of glomerular capillary, thus compromise the epithelial normal function of glomerular capillary, the original synthesis of epithelial cell is caused to be rich in the function of negative charge barrier damaged, and this function damaged after, in blood with the protein of negative charge just because epithelial barrier function is damaged, and enter into urine without obstruction, and excrete along with urine, nephropathy feature will be found after common urine examination.

Features of amyloid nephropathy clinical manifestation is stomachache, hematuria aggravation, albuminuria increase and the multiple nephrotic syndrome shape such as renal function exacerbation, not only bring serious body and mind injury to patient, also extreme influence orthobiosis of patient.Along with the progress of science, the treatment of features of amyloid nephropathy is also made some progress.But prior art treatment features of amyloid nephropathy divides 4 stages, is blood vessel dilating, alleviates renal ischemic anaerobic condition; Antiinflammatory is to alleviate damaging again of glomerular epithelium cell; Anticoagulant to alleviate thrombotic pressure, for epithelial reparation lays the foundation and degrades deposit and extracellular matrix.

As can be seen from above-mentioned therapeutic scheme, current treatment features of amyloid nephropathy mainly carries out with the way of Western medicine and Chinese Medicine and Clavicular, although reach therapeutic effect, but anti-inflammatory agent and part western medicine composition cause irreversible damage to human body, and, the maneuver that existing therapeutic scheme adopts circulation progressive, the treatment phase is long, brings spirit and economic dual-pressure to patient.

Summary of the invention

The object of the invention is to: a kind of Chinese medicine composition being used for the treatment of features of amyloid nephropathy is provided, adopt the therapy that blood vessel dilating, antiinflammatory, anticoagulation and degraded deposit and extracellular matrix synchronously carry out, reach and shorten the treatment time limit, alleviate the object of patient mental and financial burden.

To achieve these goals, the present invention adopts following technical scheme:

Be used for the treatment of a Chinese medicine composition for features of amyloid nephropathy, it is characterized in that: this Chinese medicine composition comprises following composition (in mass parts):

Radix Codonopsis 28 ~ 32 parts, the Radix Astragali 28 ~ 32 parts, Radix Angelicae Sinensis 28 ~ 32 parts, Rhizoma Chuanxiong 13 ~ 16 parts, Hirudo 13 ~ 16 parts, Pheretima 13 ~ 16 parts, 13 ~ 16 parts, Semen Persicae, 13 ~ 16 parts, Flos Carthami, Herba Lycopi 13 ~ 16 parts, Herba Leonuri 28 ~ 32 parts, 13 ~ 16 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 13 ~ 16 parts, Fructus Corni 13 ~ 16 parts, 8 ~ 12 parts, Poria, Rhizoma Alismatis 13 ~ 16 parts, Cortex Moutan 8 ~ 12 parts, the Rhizoma Atractylodis Macrocephalae 28 ~ 32 parts, the Rhizoma Pinelliae 13 ~ 16 parts, Exocarpium Citri Rubrum 13 ~ 16 parts, Ramulus Cinnamomi 18 ~ 20 parts, Bulbus Fritillariae Thunbergii 13 ~ 16 parts, Fructus Forsythiae 18 ~ 20 parts, Herba Hedyotidis Diffusae 28 ~ 32 parts, the Flos Sophorae Immaturus 28 ~ 32 parts, Fructus Lycii 28 ~ 32 parts, Herba Taxilli 13 ~ 16 parts, Cordyceps 13 ~ 16 parts, the Cortex Eucommiae 28 ~ 32 parts, Caulis et folium stauntoniae 28 ~ 32 parts, Radix Salviae Miltiorrhizae 18 ~ 20 parts, 8 ~ 12 parts, Radix Glycyrrhizae.

Further, the described Chinese medicine composition being used for the treatment of Cardiac amyloidosis can be made into capsule or pill.

Prescription side of the present invention justice and pharmacology analysis:

Radix Codonopsis: spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting, gas in tendon fortune, has spleen invigorating fortune and not dry, grows stomach-Yin and not wetting, lung moistening and do not violate cold and cool, nourishes blood and does not partially grow greasy, inspiring clear sun, gas in vibration, and without just dry fraud;

The Radix Astragali: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation, has the effect strengthening non-specific and specific immune function, protect the liver heart tonifying, regulate blood pressure;

Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, has to protect the liver and protects dirty, to promote hemopoietic, anticoagulant effect;

Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping, has suppression central nervous system, regulates effect of heart rate;

Hirudo: removing blood stasis, removing blood stasis, stimulates the menstrual flow, and has anticoagulant, thrombolytic, improves the sanguimotor effect of kidney;

Pheretima: heat clearing away, endogenous wind stopping, dredging collateral, relievings asthma, diuresis, has the effects such as antithrombotic, thrombus dissolving, enhancing immunity, blood pressure lowering;

Semen Persicae: blood stasis removing and clots absorbing, moisturizes laxation, has the effects such as blood stasis dispelling blood, antiinflammatory, antiallergic;

Flos Carthami: promoting blood circulation to restore menstrual flow, scattered silt pain relieving, has coronary artery dilator, improves myocardial ischemia, and blood vessel dilating, the effect such as reduce blood pressure;

Herba Lycopi: tonifying liver purgation of spleen excess, and QI and blood, sharp muscle, has the effect such as thrombus dissolving, anticoagulant;

Herba Leonuri: invigorate blood circulation, blood stasis dispelling, regulating menstruation, disappear water, has anticoagulant, improves coronary circulation, cardioprotection, the effect such as enhancing cardiovascular contraction;

Radix Rehmanniae Preparata: yin nourishing of enriching blood, life essence-filling, marrow-benefitting, has anticoagulant, strengthens immunologic function, promotes the effects such as hemopoietic;

Rhizoma Dioscoreae: invigorating spleen and reinforcing stomach is aid digestion, kidney nourishing and replenishing vital essence, reduction blood glucose, has blood fat reducing, strengthens the effect of immunologic function;

Fructus Corni: liver and kidney tonifying, restrains astringent or styptic treatment for spontaneous sweating, and controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping only collapses, and hidroschesis, has cardiotonic, can increase myocardial contractility and cardiac output, improves heart working efficiency;

Poria: invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, has inducing diuresis to remove edema, improves the effect such as immunity, blood fat reducing;

Rhizoma Alismatis: promoting diuresis to eliminate damp pathogen, expels the heat-evil treating stranguria, has the effect of blood fat reducing, the liver protecting, diuresis;

Cortex Moutan: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, has convulsion, analgesia, the effect of blood pressure lowering;

The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, has the effects such as diuresis, blood sugar lowering, anticoagulation, promotion hemopoietic;

The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, has antiarrhythmic effect;

Exocarpium Citri Rubrum: cold expelling, dampness, promoting the circulation of QI, expectorant, has the effect such as antiinflammatory, anticoagulant;

Ramulus Cinnamomi: relieving the exterior syndrome by diaphoresis, dispersing cold for relieving pain, activating YANG and prormoting functioning of QI, has the effects such as antibacterial, diuresis;

Bulbus Fritillariae Thunbergii: removing heat-phlegm, sending down the abnormal ascending QI cough-relieving, mass dissipating and swelling eliminating, has the effect regulating heart rate, strengthen myocardial contraction;

Fructus Forsythiae: heat clearing away, removing toxic substances, eliminating stagnation, detumescence, has antibacterial, antiviral, enhancing cardiovascular function effect;

Herba Hedyotidis Diffusae: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis to remove edema, has effect of antitumor, anti-inflammation;

The Flos Sophorae Immaturus: cooling blood for hemostasis, purging liver-fire, has the effect such as antiinflammatory, antiviral;

Fructus Lycii: nourishing the liver and kidney, replenishing vital essence to improve eyesight, has the effects such as anti-liver injury, the kidney invigorating, blood sugar lowering;

Herba Taxilli: invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, has the effects such as blood pressure lowering, diuresis, blood vessel dilating, antithrombotic;

Cordyceps: invigorating the lung and the kidney, preventing phlegm from forming and stopping coughing, has and regulates excretory system and nervous system, changes effect of microcirculation in human body;

The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive, there is the effect such as blood pressure lowering, diuresis;

Caulis et folium stauntoniae: promoting blood circulation to remove blood stasis, damp eliminating diuresis, heat-clearing and toxic substances removing;

Radix Salviae Miltiorrhizae: control blood system, removes stagnant tissue regeneration promoting, and regulating menstruation, along arteries and veins, has effect such as reparation and regeneration of heart tonifying, blood vessel dilating, increase myocardial flow, antithrombus formation, promotion tissue;

Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, has the effect of coordinating the actions of various ingredients in a prescription.

Pharmacology and beneficial effect thereof:

The present invention adopts the method for blood vessel dilating, antiinflammatory, anticoagulation and degrade deposit and extracellular matrix synchronous therapeutic, fast treating features of amyloid nephropathy, alleviate spirit and the economic pressures of patient, and this medicine is pure Chinese medicine formula, there is the advantage that property of medicine gentleness, zest are little, have no side effect.

Administrated method: boiled water is taken after mixing it with water, every day 2 times, each 2 of pill, each 4 of capsule, 4 ~ 7 courses for the treatment of just can cure, 7 days each courses for the treatment of.

Medication is avoided:

1) tobacco and wine, pungent, irritable food is avoided during medication;

2) be not taken by pregnant women use;

3) nephrotic should medication under doctor instructs.

Detailed description of the invention

Below in conjunction with instantiation, technical scheme of the present invention is described further.

Embodiment 1

Be used for the treatment of a Chinese medicine composition for features of amyloid nephropathy, be made up of following medicinal raw material:

Radix Codonopsis 30g, Radix Astragali 30g, Radix Angelicae Sinensis 30g, Rhizoma Chuanxiong 15g, Hirudo 15g, Pheretima 15g, Semen Persicae 15g, Flos Carthami 15g, Herba Lycopi 15g, Herba Leonuri 30g, Radix Rehmanniae Preparata 15g, Rhizoma Dioscoreae 15g, Fructus Corni 15g, Poria 10g, Rhizoma Alismatis 15g, Cortex Moutan 10g, Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Pinelliae 15g, Exocarpium Citri Rubrum 15g, Ramulus Cinnamomi 20g, Bulbus Fritillariae Thunbergii 15g, Fructus Forsythiae 20g, Herba Hedyotidis Diffusae 30g, Flos Sophorae Immaturus 30g, Fructus Lycii 30g, Herba Taxilli 15g, Cordyceps 15g, Cortex Eucommiae 30g, Caulis et folium stauntoniae 30g, Radix Salviae Miltiorrhizae 20g, Radix Glycyrrhizae 10g.

Boil medicine according to above-mentioned formula, extract filtering residue medicinal liquid, sterilize after evaporation and concentration, sterilize, then adopt the preparation technology of pill medicine to make pill.

Embodiment 2

Be used for the treatment of a Chinese medicine composition for features of amyloid nephropathy, be made up of following medicinal raw material:

Radix Codonopsis 28g, Radix Astragali 28g, Radix Angelicae Sinensis 28g, Rhizoma Chuanxiong 14g, Hirudo 16g, Pheretima 14g, Semen Persicae 14g, Flos Carthami 16g, Herba Lycopi 14g, Herba Leonuri 32g, Radix Rehmanniae Preparata 16g, Rhizoma Dioscoreae 14g, Fructus Corni 14g, Poria 8g, Rhizoma Alismatis 14g, Cortex Moutan 10g, Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Pinelliae 16g, Exocarpium Citri Rubrum 16g, Ramulus Cinnamomi 20g, Bulbus Fritillariae Thunbergii 16g, Fructus Forsythiae 20g, Herba Hedyotidis Diffusae 32g, Flos Sophorae Immaturus 28g, Fructus Lycii 28g, Herba Taxilli 14g, Cordyceps 16g, Cortex Eucommiae 32g, Caulis et folium stauntoniae 28g, Radix Salviae Miltiorrhizae 20g, Radix Glycyrrhizae 8g.

Boil medicine according to above-mentioned formula, rear extraction filtering residue medicinal liquid, evaporates whole moisture, and obtained powder, then crosses 50 mesh sieves, then through sterilization, sterilization, then adopt the preparation technology of pharmaceutical capsules to make capsule.

Medicine of the present invention proves through clinical trial, and cure rate 78%, effective percentage 96.4%, without rebound phenomenon.

In order to further illustrate the actual effect of medicine of the present invention, list the medical case of part below:

Case 1: Zhang, man, 61 years old, disease showed as: puffiness of the face and limbs, weak breath is weak, shallow complexion, uncomfortable in chest indigestion and loss of appetite, and soreness of waist twinge is more than 2 years, look into tongue fur dimness or have ecchymosis, tongue is slightly greasy in vain, thready and weak pulse, have urine examined routine, urine protein (++), is hypoproteinemia, through many examination in hospital, be diagnosed as features of amyloid nephropathy, but repeatedly treat without positive effect, adopt medicine of the present invention to treat on March 25th, 2010, within 20 days, check that symptom obviously alleviates afterwards, within 52 days, check afterwards and thoroughly cure.

Case 2: single certain, man, 57 years old, disease showed as: slight edema, dry mouth and throat, feverish sensation in the palms and soles, soreness of waist twinge, oliguria with reddish urine, constipation with dry stool, red tongue, has ecchymosis, the micro-greasy flower stripping of tongue fur, thready and weak pulse, have urine examined albumen (+), and have a blood test albumin 35g/L, through many examination in hospital, be diagnosed as features of amyloid nephropathy, but repeatedly treat without positive effect, adopt medicine of the present invention to treat on August 3rd, 2011, within 15 days, check that symptom obviously alleviates afterwards, within 38 days, check afterwards and thoroughly cure.

Case 3: in certain, female, 45 years old, limbs were micro-swollen, complexion is de-white, weak poor appetite, chronognosis shortness of breath and palpitation, dry mouth and throat, soreness of waist twinge, have urine examined albumen (+), erythrocyte (+), and dimly red tongue has ecchymosis point, tongue is greasy in vain, and deep pulse is thin and delicate, more than a year ill, through many examination in hospital, be diagnosed as features of amyloid nephropathy, but repeatedly treat without positive effect, adopt medicine of the present invention to treat on October 8th, 2012, within 18 days, check that symptom obviously alleviates afterwards, within 43 days, check afterwards and thoroughly cure.

Be more than several examples in numerous case, do not represent all cases, find by analysis, after adopting Drug therapy of the present invention, patient's body's immunity obviously strengthens, and liver internal organs function also can recover normal.

Claims (2)

1. be used for the treatment of a Chinese medicine composition for features of amyloid nephropathy, it is characterized in that: this Chinese medicine composition comprises following composition (in mass parts):

Radix Codonopsis 28 ~ 32 parts, the Radix Astragali 28 ~ 32 parts, Radix Angelicae Sinensis 28 ~ 32 parts, Rhizoma Chuanxiong 13 ~ 16 parts, Hirudo 13 ~ 16 parts, Pheretima 13 ~ 16 parts, 13 ~ 16 parts, Semen Persicae, 13 ~ 16 parts, Flos Carthami, Herba Lycopi 13 ~ 16 parts, Herba Leonuri 28 ~ 32 parts, 13 ~ 16 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 13 ~ 16 parts, Fructus Corni 13 ~ 16 parts, 8 ~ 12 parts, Poria, Rhizoma Alismatis 13 ~ 16 parts, Cortex Moutan 8 ~ 12 parts, the Rhizoma Atractylodis Macrocephalae 28 ~ 32 parts, the Rhizoma Pinelliae 13 ~ 16 parts, Exocarpium Citri Rubrum 13 ~ 16 parts, Ramulus Cinnamomi 18 ~ 20 parts, Bulbus Fritillariae Thunbergii 13 ~ 16 parts, Fructus Forsythiae 18 ~ 20 parts, Herba Hedyotidis Diffusae 28 ~ 32 parts, the Flos Sophorae Immaturus 28 ~ 32 parts, Fructus Lycii 28 ~ 32 parts, Herba Taxilli 13 ~ 16 parts, Cordyceps 13 ~ 16 parts, the Cortex Eucommiae 28 ~ 32 parts, Caulis et folium stauntoniae 28 ~ 32 parts, Radix Salviae Miltiorrhizae 18 ~ 20 parts, 8 ~ 12 parts, Radix Glycyrrhizae.

2. a kind of Chinese medicine composition being used for the treatment of features of amyloid nephropathy as claimed in claim 1, is characterized in that: the described Chinese medicine composition being used for the treatment of Cardiac amyloidosis can be made into capsule or pill.