CN103536866B - Traditional Chinese medicine composition for treating inflammatory intestinal obstruction after abdominal operation and application thereof - Google Patents
Traditional Chinese medicine composition for treating inflammatory intestinal obstruction after abdominal operation and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating inflammatory intestinal obstruction after abdominal operation and application thereof. The composite is prepared from the following components in parts by weight: 22-35 parts of cassia seed, 22-35 parts of lalang grass rhizome, 40-56 parts of dried tangerine or orange peel, 16-24 parts of curcuma zedoary, 16-24 parts of radix angelicae, 22-35 parts of herba patriniae, 22-35 parts of perilla leaf, 13-22 parts of roasted Rhizoma Atractylodis Macrocephalae, 13-22 parts of roasted fructus aurantii, 50-70 parts of lotus leaf and 8-16 parts of licorice root. The traditional Chinese medicine composition provided by the invention is used for treating inflammatory intestinal obstruction in early stage after abdominal operation, not only can quickly eliminate the intestinal obstruction symptoms, but also can remove inflammation after enteric cavity operation.
Description
technical field
The present invention relates to a kind of Chinese medicine composition and application thereof for the treatment of inflammatory intestinal obstruction after abdominal operation, belong to technical field of Chinese medicines.
Background technology
Postoperative inflammatory small bowel obstruction is a kind of early stage disease, falls ill the earliest in all intestinal obstruction, if do not treated in time, is easy to, to the development of viscosity intestinal obstruction, even change strangulated intestinal obstruction into, add the misery of heavy patient greatly, injure the life of patient.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition and application thereof for the treatment of inflammatory intestinal obstruction after abdominal operation.
The object of the present invention is achieved like this:
Treat a Chinese medicine composition for inflammatory intestinal obstruction after abdominal operation, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Semen Cassiae 22-35 part, Rhizoma Imperatae 22-35 part, Pericarpium Citri Reticulatae 40-56 part, Rhizoma Curcumae 16-24 part, Radix Angelicae Dahuricae 16-24 part, Herba Patriniae 22-35 part, Folium Perillae 22-35 part, Rhizoma Atractylodis Macrocephalae (parched) 13-22 part, Fructus Aurantii (parched) 13-22 part, Folium Nelumbinis 50-70 part, Radix Glycyrrhizae 8-16 part.
Preferably, the Chinese medicine composition for the treatment of inflammatory intestinal obstruction after abdominal operation as above, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Semen Cassiae 22-30 part, Rhizoma Imperatae 22-30 part, Pericarpium Citri Reticulatae 40-50 part, Rhizoma Curcumae 16-20 part, Radix Angelicae Dahuricae 16-20 part, Herba Patriniae 22-30 part, Folium Perillae 22-30 part, Rhizoma Atractylodis Macrocephalae (parched) 13-20 part, Fructus Aurantii (parched) 13-20 part, Folium Nelumbinis 50-65 part, Radix Glycyrrhizae 8-14 part.
In the present invention's most preferred embodiment, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Semen Cassiae 30 parts, Rhizoma Imperatae 30 parts, Pericarpium Citri Reticulatae 48 parts, Rhizoma Curcumae 20 parts, the Radix Angelicae Dahuricae 20 parts, Herba Patriniae 30 parts, Folium Perillae 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 18 parts, Fructus Aurantii (parched) 18 parts, 60 parts, Folium Nelumbinis, 12 parts, Radix Glycyrrhizae.
Further preferably, the Chinese medicine composition of described treatment inflammatory intestinal obstruction after abdominal operation is liquid preparation.
Found by a large amount of clinical experimental study, the pharmaceutical composition be prepared from by above-mentioned traditional Chinese medicinal material raw materials has significant curative effect in treatment inflammatory intestinal obstruction after abdominal operation.Therefore, second object of the present invention is to provide a kind of new medical use, the application of namely above-mentioned Chinese medicine composition in the medicine of preparation treatment inflammatory intestinal obstruction after abdominal operation.
According to Chinese medicine Historical Data Data About, above-mentioned traditional Chinese medicinal material raw materials has following pharmacologically active and function cures mainly: Semen Cassiae: clearing away heat to improve acuity of vision, and intestine moistening is led to.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.Select the dry mature seed of pulse family annual herb plant Semen Cassiae or little Semen Cassiae.Rhizoma Imperatae: removing heat from blood, hemostasis, heat clearing away, diuresis.Control calentura excessive thirst, spit blood, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.Select the dry rhizome of grass Herba Imperatae Imperata cylindrical (L.) Beauv. var. major (Nees) C. E. Hubb..Pericarpium Citri Reticulatae: there is regulating qi-flowing for strengthening spleen, in tune, dampness, the effect of reducing phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool.Phlegm-damp stops up the cough and asthma of lung.Select the dry mature skin for rutaceae orange and variety thereof.Rhizoma Curcumae: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.Select the rhizome of zingiberaceous plant C. kwangsinensis Curcuam kwangsiensis S.G.Leset C.F.Liang.The Radix Angelicae Dahuricae: wind-damp dispelling, evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.For headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Select the root of samphire angelica anomala.Herba Patriniae: have another name called Herba Ixeritis chinensis, selects herb and the root of feverfew Herba Ixeritis chinensis.Herba Patriniae heat-clearing and toxic substances removing, removing heat from blood, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing.For acute appendicitis, the high heat of lung abscess, coughs vomiting bloody pus, pyretic toxicity skin ulcer furuncle, and furuncle pain is swollen, breast abdomen pain, appendicitis, enteritis, dysentery, puerperal abdonimal pain, dysmenorrhea.Folium Perillae: expelling cold and relieving exterior syndrome, regulating the flow of QI to ease the stomach.For anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen.Select the leaf of labiate wrinkle Folium Perillae, sharp Folium Perillae etc.The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Select the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Fructus Aurantii: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.Select the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L..Folium Nelumbinis: clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.For summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen, heat in blood tells nosebleed, metrorrhagia of having blood in stool.Select the dried leaves of nymphaeaceae plant lotus Nelumbo nuciferaGaertn..Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Select as dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. G. inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G. glabra L..
Above-mentioned each Chinese crude drug is prepared into the preparation method of compound recipe medicinal liquid of the present invention, comprise the steps: to take and clean up and the merging of the medical material of drying, decoct with water twice, collecting decoction, when being evaporated to 70 DEG C, relative density is 1.15-1.20, adding ethanol makes the percent by volume of alcohol content reach 75-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25-1.30 and reclaims ethanol to obtain concentrated solution, is added water by concentrated solution and auxiliaries becomes medicinal liquid.
Chinese medicine composition of the present invention is used for the treatment of the postoperative inflammatory small bowel obstruction that abdominal postoperative occurs in early days, both the ileac symptom of patient can be eliminated faster, can be disappeared again the postoperative inflammation of enteric cavity, alleviate the load of intestinal tube, promote the absorption of intestinal juice, prevent from forming adhesion between intestinal tube, be conducive to the recovery of gastrointestinal function, thus reach analgesic antiphlogistic, reduce the incidence rate of complication, make patient's early recovery.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for the present invention is described, instead of limitation of the present invention, under concept thereof of the present invention, all belong to the scope of protection of present invention to the simple modifications of preparation method of the present invention.
Embodiment 1
Crude drug prescription: Semen Cassiae 3kg, Rhizoma Imperatae 3kg, Pericarpium Citri Reticulatae 4.8kg, Rhizoma Curcumae 2kg, Radix Angelicae Dahuricae 2kg, Herba Patriniae 3kg, Folium Perillae 3kg, Rhizoma Atractylodis Macrocephalae (parched) 1.8kg, Fructus Aurantii (parched) 1.8kg, Folium Nelumbinis 6kg, Radix Glycyrrhizae 1.2kg.
Preparation method: the medical material taking above-mentioned recipe quantity merges, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 2h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, relative density is 1.15 when being evaporated to 70 DEG C at 70 DEG C, adds 95% (v/v) ethanol and makes alcohol content reach 75% (v/v), stir, hold over night, filter, under 0.08MPa, 65 DEG C of conditions, concentrating under reduced pressure becomes filtrate is 1.30 to relative density when 65 DEG C, adds water and sucrose is mixed with medicinal liquid.
Embodiment 2
Crude drug prescription: Semen Cassiae 2.2kg, Rhizoma Imperatae 3.4kg, Pericarpium Citri Reticulatae 5.6kg, Rhizoma Curcumae 1.6kg, Radix Angelicae Dahuricae 1.6kg, Herba Patriniae 2.2kg, Folium Perillae 3.4kg, Rhizoma Atractylodis Macrocephalae (parched) 2.2kg, Fructus Aurantii (parched) 2kg, Folium Nelumbinis 5.1kg, Radix Glycyrrhizae 1kg.
Preparation method: the medical material taking above-mentioned recipe quantity merges, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 2h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, relative density is 1.15 when being evaporated to 70 DEG C at 70 DEG C, adds 95% (v/v) ethanol and makes alcohol content reach 85% (v/v), stir, hold over night, filter, under 0.08MPa, 65 DEG C of conditions, concentrating under reduced pressure becomes filtrate is 1.30 to relative density when 65 DEG C, adds water and sucrose is mixed with medicinal liquid.
Embodiment 3
Crude drug prescription: Semen Cassiae 3.5kg, Rhizoma Imperatae 2.2kg, Pericarpium Citri Reticulatae 4.2kg, Rhizoma Curcumae 2.2kg, Radix Angelicae Dahuricae 2kg, Herba Patriniae 3.5kg, Folium Perillae 2.2kg, Rhizoma Atractylodis Macrocephalae (parched) 2kg, Fructus Aurantii (parched) 1.5kg, Folium Nelumbinis 7kg, Radix Glycyrrhizae 1.5kg.
Preparation method: the medical material taking above-mentioned recipe quantity merges, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 2h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, relative density is 1.20 when being evaporated to 70 DEG C at 70 DEG C, adds 95% (v/v) ethanol and makes alcohol content reach 80% (v/v), stir, hold over night, filter, under 0.08MPa, 65 DEG C of conditions, concentrating under reduced pressure becomes filtrate is 1.30 to relative density when 65 DEG C, adds water and sucrose is mixed with medicinal liquid.
Embodiment 4 Chinese medicine composition of the present invention is on the impact of severe inflammatory intestinal obstruction after abdominal operation patient
Prepared by traditional Chinese medicine sample: take Semen Cassiae 30 parts, Rhizoma Imperatae 30 parts, Pericarpium Citri Reticulatae 48 parts, Rhizoma Curcumae 20 parts, the Radix Angelicae Dahuricae 20 parts, Herba Patriniae 30 parts, Folium Perillae 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 18 parts, Fructus Aurantii (parched) 18 parts, 60 parts, Folium Nelumbinis and 12 parts, Radix Glycyrrhizae, the medical material of above-mentioned recipe quantity is merged, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 2h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, when being evaporated to 70 DEG C at 70 DEG C, relative density is 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, hold over night, filter, filtrate is at 0.08MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.30 to relative density when 65 DEG C, .
Be diagnosed as and suffer from the ileac 92 routine patients of abdominal post-operation, the age, in year mean age (29.40 ± 5.07), fever time was 4 ~ 12 d, and average fever time is (6.4 ± 1.9) d at 23 ~ 50 years old.Carry out abdominal postoperative vomit, bitterly, close, the swollen cardinal symptom for patient.All patients are divided into Chinese drug-treated group (47 example) and matched group (45 example) at random, and two groups do not have significant difference, have comparability in sex, age, the course of disease etc.
The traditional Chinese medicine sample medicinal liquid that Chinese drug-treated group uses said method to prepare, concrete grammar is as follows: each oral 100mL medicinal liquid, and every day is sooner or later respectively once; Get 100mL for low level retention enema, once a day simultaneously.Matched group patient uses traditional Western medicine therapy to treat, and concrete method is: acupoint injection therapy vitamin B
1, intramuscular injection neostigmine, and carry out coloclysis with the normal saline of same volume.Observe and compare the improvement degree of the symptoms such as two groups of patient's abdominal distention stomachache, micturition time, indigestion and loss of appetite and nausea and vomiting.The standard of Outcome measure is as follows:
Cure: process treats cardinal symptom disappearance within 48 h after surgery and anus starts aerofluxus;
Effective: to start aerofluxus through treating cardinal symptom disappearance or anus within 48 ~ 72 h after surgery;
Effective: to start aerofluxus through treating cardinal symptom disappearance or anus within 72 ~ 96 h after surgery;
Invalid: not disappear or anus does not have aerofluxus through treating 96h and abnormal cardinal symptom after surgery.
Result of the test shows, Chinese drug-treated group patient is obviously better than matched group for the improvement degree of patients symptomatic, and total effective rate is also obvious high than matched group, illustrate that traditional Chinese medicine composition for treating abdominal post-operation postoperative inflammatory small bowel obstruction of the present invention has good clinical efficacy, specifically see table 1.
Table 1 liang group overall patient comparitive study
Claims (3)
1. treat a Chinese medicine composition for inflammatory intestinal obstruction after abdominal operation, it is characterized in that: described Chinese medicine composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Semen Cassiae 30 parts, Rhizoma Imperatae 30 parts, Pericarpium Citri Reticulatae 48 parts, Rhizoma Curcumae 20 parts, the Radix Angelicae Dahuricae 20 parts, Herba Patriniae 30 parts, Folium Perillae 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 18 parts, Fructus Aurantii (parched) 18 parts, 60 parts, Folium Nelumbinis, 12 parts, Radix Glycyrrhizae.
2. the Chinese medicine composition for the treatment of inflammatory intestinal obstruction after abdominal operation according to claim 1, is characterized in that: described Chinese medicine composition is liquid preparation.
3. the application of pharmaceutical composition according to claim 1 in the medicine of preparation treatment inflammatory intestinal obstruction after abdominal operation.
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